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https://www.readbyqxmd.com/read/29773412/athlete-s-heart-is-the-morganroth-hypothesis-obsolete
#1
Mark J Haykowsky, T Jake Samuel, Michael D Nelson, Andre La Gerche
In 1975, Morganroth and colleagues reported that the increased left ventricular (LV) mass in highly trained endurance athletes versus nonathletes was primarily due to increased end-diastolic volume while the increased LV mass in resistance trained athletes was solely due to an increased LV wall thickness. Based on the divergent remodelling patterns observed, Morganroth and colleagues hypothesised that the increased "volume" load during endurance exercise may be similar to that which occurs in patients with mitral or aortic regurgitation while the "pressure" load associated with performing a Valsalva manoeuvre (VM) during resistance exercise may mimic the stress imposed on the heart by systemic hypertension or aortic stenosis...
May 1, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29770201/recent-advances-in-managing-septal-defects-ventricular-septal-defects-and-atrioventricular-septal-defects
#2
REVIEW
P Syamasundar Rao, Andrea D Harris
This review discusses the management of ventricular septal defects (VSDs) and atrioventricular septal defects (AVSDs). There are several types of VSDs: perimembranous, supracristal, atrioventricular septal, and muscular. The indications for closure are moderate to large VSDs with enlarged left atrium and left ventricle or elevated pulmonary artery pressure (or both) and a pulmonary-to-systemic flow ratio greater than 2:1. Surgical closure is recommended for large perimembranous VSDs, supracristal VSDs, and VSDs with aortic valve prolapse...
2018: F1000Research
https://www.readbyqxmd.com/read/29768162/-structural-and-functional-changes-of-blood-vessels-in-women-in-early-postmenopause-the-possibility-of-correction-of-the-revealed-violations
#3
S N Tolstov, I A Salov, A P Rebrov
AIM: To evaluate severity and pattern of structural and functional changes of vascular wall in early postmenopausal women receiving chronic treatment with a low-dose combination of 17β-estradiol (E2) 1 mg and drospirenone 2 mg (DRSP). Evaluation of structural and functional arterial remodeling might be important for assessment of cardiovascular risk in postmenopausal women. MATERIALS AND METHODS: The study included 162 early postmenopausal women with postmenopausal syndrome...
2018: Kardiologiia
https://www.readbyqxmd.com/read/29766008/diagnostic-utility-of-chest-radiography-in-predicting-long-standing-systemic-arterial-hypertension
#4
Hakan Sahin, Paul Stark
Purpose: To investigate the association between aortic arch width on frontal chest radiography and systemic hypertension. Methods: A total of 200 consecutive patients were included. Relationships between aortic arch width measurement on chest radiography and blood pressure measurement were investigated using Student's t -tests and Fisher's exact tests. Results: Twenty-five patients were normotensive (< 130/90 mmHg), and 175 were hypertensive...
December 2017: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/29765465/the-development-or-worsening-of-hypertension-after-transcatheter-aortic-valve-replacement-tavr-improves-short-term-and-long-term-patient-outcomes
#5
Brent J Klinkhammer, Cornelius M Dyke, Thomas A Haldis
Objectives: In patients with symptomatic aortic valve disease who are at intermediate to high risk for open surgical aortic valve replacement, transcatheter aortic valve replacement (TAVR) decreases overall mortality and improves quality of life. Hypertension (HTN) after TAVR has been associated with improved cardiac function and short-term survival but its effect on survival over 1 year is unclear. Our study aims to evaluate the effect of HTN following TAVR on short-term and long-term clinical and echocardiographic outcomes...
2018: Heart Asia
https://www.readbyqxmd.com/read/29765328/long-term-consumption-of-cuban-policosanol-lowers-central-and-brachial-blood-pressure-and-improves-lipid-profile-with-enhancement-of-lipoprotein-properties-in-healthy-korean-participants
#6
Suk-Jeong Kim, Dhananjay Yadav, Hye-Jeong Park, Jae-Ryong Kim, Kyung-Hyun Cho
Metabolic syndrome is closely associated with higher risk of hypertension, cardiovascular disease (CVD), diabetes and stroke. The aim of the present study was to investigate the long-term effects of policosanol supplementation on blood pressure (BP) and the lipid profile in healthy Korean participants with pre-hypertension (systolic 120-139 mmHg, diastolic 85-89 mmHg). This randomized, double-blinded, and placebo-controlled trial included 84 healthy participants who were randomly assigned to three groups receiving 10 mg of policosanol, 20 mg of policosanol, or placebo for 24 weeks...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29764687/intraoperative-aortic-root-pressure-study-for-quantitative-assessment-of-aortic-regurgitation-during-valve-sparing-root-replacement-a-preliminary-report
#7
Yuki Ikeno, Hiroshi Tanaka, Yutaka Okita
No abstract text is available yet for this article.
April 17, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29763373/oral-glucose-challenge-impairs-skeletal-muscle-microvascular-blood-flow-in-healthy-people
#8
Ryan D Russell, Donghua Hu, Timothy Greenaway, James E Sharman, Stephen Rattigan, Stephen M Richards, Michelle A Keske
Skeletal muscle microvascular (capillary) blood flow increases in the post-prandial state or during insulin infusion due to dilation of pre-capillary arterioles to augment glucose disposal. This effect occurs independent of changes in large artery function. However, acute hyperglycemia impairs vascular function, causes insulin to vasoconstrict pre-capillary arterioles, and causes muscle insulin resistance in vivo. We hypothesize that acute hyperglycemia impairs post-prandial muscle microvascular perfusion, without disrupting normal large artery hemodynamics, in healthy humans...
May 15, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29762920/outcomes-of-a-new-generation-stentless-aortic-valve-a-single-center-experience-with-251-consecutive-implants
#9
Guglielmo Stefanelli, Fabrizio Pirro, Giuseppe Danniballe, Alina Olaru, Marco Meli, Luca Weltert
BACKGROUND: The study aim was to investigate the hemodynamic behavior over time and ease of implant and durability of the Sorin Pericarbon Freedom (SPF)® stentless pericardial aortic xenograft. METHODS: Between March 2003 and April 2010, a total of 251 consecutive, non-selected patients (mean age 70.1 years; range: 17-89 years; 17.1% aged >80 years) received a SPF bioprosthesis as an aortic valve substitute at the authors' institution. All implantations were performed by a single surgeon using a classical, double-line, subcoronary implant technique...
September 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29761247/beneficial-effects-of-fenofibrate-in-pulmonary-hypertension-in-rats
#10
Palak Galhotra, Pankaj Prabhakar, Himanshu Meghwani, Soheb A Mohammed, Sanjay Kumar Banerjee, Sandeep Seth, Milind P Hote, K H Reeta, Ruma Ray, Subir Kumar Maulik
Pulmonary hypertension (PH) is a morbid complication of cardiopulmonary as well as several systemic diseases in humans. It is rapidly progressive and fatal if left untreated. In the present study, we investigated the effect of PPARα agonist fenofibrate (FF) on monocrotaline (MCT)-induced PH in rats. FF, because of its pleiotropic property, could be helpful in reducing inflammation, oxidative stress, and reactive oxygen species. On day 1, MCT (50 mg/kg, s.c.) was given to all the rats in MCT, sildenafil, and FF group except normal control rats...
May 14, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29761089/association-of-haemodynamic-indices-of-central-and-peripheral-pressure-with-subclinical-target-organ-damage
#11
Junli Zuo, Shaoli Chu, Isabella Tan, Mark Butlin, Jiehui Zhao, Alberto Avolio
Background: Central aortic pressure has often been shown to be more closely associated with markers of vascular function and incidence of cardiovascular events compared to peripheral pressure. However, the potential clinical use of central aortic or peripheral haemodynamic indices as markers of target organ damage (TOD) has not been fully established. Methods: We evaluated associations of TOD with central aortic and peripheral haemodynamic indices (central aortic [cPP] and peripheral pulse pressure [pPP], central aortic augmentation index, and central and peripheral waveform factor) in 770 hospital inpatients (age 60 ± 10 years, 473 males) with primary hypertension...
March 2018: Pulse (Basel, Switzerland)
https://www.readbyqxmd.com/read/29761086/aortic-brachial-pulse-wave-velocity-ratio-a-measure-of-arterial-stiffness-gradient-not-affected-by-mean-arterial-pressure
#12
REVIEW
Catherine Fortier, Marie-Pier Desjardins, Mohsen Agharazii
Background: Aortic stiffness, measured by carotid-femoral pulse wave velocity (cf-PWV), is used for the prediction of cardiovascular risk. This mini-review describes the nonlinear relationship between cf-PWV and operational blood pressure, presents the proposed methods to adjust for this relationship, and discusses a potential place for aortic-brachial PWV ratio (a measure of arterial stiffness gradient) as a blood pressure-independent measure of vascular aging. Summary: PWV is inherently dependent on the operational blood pressure...
March 2018: Pulse (Basel, Switzerland)
https://www.readbyqxmd.com/read/29761081/enhanced-aortic-pressure-wave-reflection-in-patients-with-aortic-coarctation-after-aortic-arch-repair
#13
REVIEW
Tomoaki Murakami
Background: In patients with aortic coarctation after successful aortic arch repair, it is well known that early-onset cardiovascular diseases can develop. Summary: We studied the pressure waveform in patients after aortic arch repair focusing on a pressure wave reflection. In patients after aortic arch repair, the repaired portion generates a new reflected pressure wave. As a result, the newly generated pressure wave causes aortic pressure augmentation, loss of pressure amplification, and left ventricular hypertrophy with fibrosis...
March 2018: Pulse (Basel, Switzerland)
https://www.readbyqxmd.com/read/29760913/evaluation-of-a-modified-cheatham-platinum-stent-for-the-treatment-of-aortic-coarctation-by-finite-element-modelling
#14
Barbara Eu Burkhardt, Nicholas Byrne, Marí Nieves Velasco Forte, Francesco Iannaccone, Matthieu De Beule, Gareth J Morgan, Tarique Hussain
Objectives: Stent implantation for the treatment of aortic coarctation has become a standard approach for the management of older children and adults. Criteria for optimal stent design and construction remain undefined. This study used computational modelling to compare the performance of two generations of the Cheatham-Platinum stent (NuMED, Hopkinton, NY, USA) deployed in aortic coarctation using finite element analysis. Design: Three-dimensional models of both stents, reverse engineered from microCT scans, were implanted in the aortic model of one representative patient...
January 2018: JRSM Cardiovascular Disease
https://www.readbyqxmd.com/read/29759947/a-simplified-method-to-account-for-wall-motion-in-patient-specific-blood-flow-simulations-of-aortic-dissection-comparison-with-fluid-structure-interaction
#15
Mirko Bonfanti, Stavroula Balabani, Mona Alimohammadi, Obiekezie Agu, Shervanthi Homer-Vanniasinkam, Vanessa Díaz-Zuccarini
Aortic dissection (AD) is a complex and highly patient-specific vascular condition difficult to treat. Computational fluid dynamics (CFD) can aid the medical management of this pathology, yet its modelling and simulation are challenging. One aspect usually disregarded when modelling AD is the motion of the vessel wall, which has been shown to significantly impact simulation results. Fluid-structure interaction (FSI) methods are difficult to implement and are subject to assumptions regarding the mechanical properties of the vessel wall, which cannot be retrieved non-invasively...
May 11, 2018: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29756692/the-presence-of-elastic-compression-stockings-reduces-the-fluid-responsiveness-of-patients-in-the-operating-room
#16
Elie Zogheib, Julien Maizel, Nabil Cherradi, Ammar Benammar, Béatrice Labont, Abdel Hchikat, Michael Bernasinski, Faouzi Trojette, Michel Slama, Hervé Dupont
BACKGROUND: To investigate whether elastic compression stockings (ECS) can affect fluid responsiveness parameters before and during passive leg raising (PLR) maneuvers. METHODS: In the operating room (OR), we performed a prospective study including patients referred for cardiac surgery. Blood pressure (BP), ΔPP, heart rate (HR), central venous pressure (CVP), stroke volume (SV) and aortic blood flow (ABF) (by esophageal doppler) were measured according to four conditions: supine position without ECS (baseline 1), lower limbs raised to an angle of 45° (PLR 1), returned to the supine position with ECS (baseline 2), then a second PLR maneuver with ECS was performed (PLR 2)...
May 11, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29756640/aortic-valve-hemodynamics-in-atrial-fibrillation-should-the-highest-doppler-signal-be-used-to-estimate-severity-of-aortic-stenosis
#17
Said Alsidawi, Sana Khan, Sorin V Pislaru, Vuyisile T Nkomo
Grading severity of AS in AF is complicated by varying stroke volumes associated with fluctuating maximum velocities and pressure gradients across the aortic valve. Current guidelines recommend averaging five continuous-wave peak velocity and mean gradient (MG) Doppler signals across the aortic valve when estimating severity of AS in AF. However, it is unknown when grading severity of AS how the average of multiple Doppler signals vs the highest Doppler signal in AF compares to the Doppler signals when the patient is in normal sinus rhythm...
May 14, 2018: Echocardiography
https://www.readbyqxmd.com/read/29754919/balloon-expandable-stents-for-recoarctation-of-the-aorta-in-small-children-two-centre-experience
#18
K Gendera, P Ewert, D Tanase, S Georgiev, T Genz, P Bambul Heck, T Moszura, I Malcic, J Cleuziou, A Eicken
BACKGROUND: In young patients with native aortic coarctation (CoA), the management of choice is surgery. However, in re-coarctation (re-CoA) surgery is associated with increased morbidity and even mortality. Some children with native CoA present relative contraindications for surgery. METHODS: From 2006 to 2017, thirty-four patients (male n = 20; 59%) from two centres with re-CoA (31) and native CoA (3) were managed by stent implantation with premounted balloon expandable stents...
July 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29754737/biomechanical-characterization-of-the-native-porcine-aortic-root
#19
T Bechsgaard, T Lindskow, T Lading, J M Hasenkam, D M Røpcke, H Nygaard, P Johansen, S L Nielsen
A thorough understanding of the well-functioning, native aortic root is pivotal in an era, where valve sparing surgical techniques are developed and used with increasing frequency. The objective of this study was to characterize the local structural stiffness of the native aortic root, to create a baseline for understanding how different surgical interventions affect the dynamics of the aortic root. In this acute porcine study (N = 10), two dedicated force transducers were implanted to quantify the forces acting on both the annular plane and on the sinotubular junction (STJ)...
May 3, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29754660/predictors-of-intra-aortic-balloon-pump-hemodynamic-failure-in-non-acute-myocardial-infarction-cardiogenic-shock
#20
Steven Hsu, Swetha Kambhampati, Christopher M Sciortino, Stuart D Russell, Steven P Schulman
OBJECTIVES: To characterize patient profile and hemodynamic profile of those undergoing intra-aortic balloon pump (IABP) for cardiogenic shock and define predictors of hemodynamic failure of IABP support. BACKGROUND: Clinical characteristics of IABP support in cardiogenic shock not related to acute myocardial infarction (AMI) remain poorly characterized. METHODS: We retrospectively studied a cohort of 74 patients from 2010 to 2015 who underwent IABP insertion for cardiogenic shock complicating acute decompensated heart failure not due to AMI...
May 2018: American Heart Journal
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