Pedro Santana Sales Lauria, Juliana de Medeiros Gomes, Lucas Silva Abreu, Rejane Conceição Santana, Victor Luiz Correia Nunes, Ricardo David Couto, Paulo Oliveira Colavolpe, Marcelo Sobral da Silva, Milena Botelho Pereira Soares, Cristiane Flora Villarreal
ETHNOPHARMACOLOGICAL RELEVANCE: Ayahuasca (AYA) is a psychedelic brew used in religious ceremonies. It is broadly used as a sacred medicine for treating several ailments, including pain of various origins. AIM OF THE STUDY: To investigate the antinociceptive effects of AYA and its mechanisms in preclinical models of acute and chronic pain in mice, in particular during experimental neuropathy. MATERIALS AND METHODS: The antinociceptive effects of AYA administered orally were assessed in the following models of pain: formalin test, Complete Freund's Adjuvant (CFA)-induced inflammation, tail flick test, and partial sciatic nerve ligation model of neuropathic pain...
January 4, 2024: Journal of Ethnopharmacology