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Natural killer and miscarriage

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https://www.readbyqxmd.com/read/27865124/the-killer-cell-story-in-recurrent-miscarriage-association-between-activated-peripheral-lymphocytes-and-uterine-natural-killer-cells
#1
R J Kuon, K Vomstein, M Weber, F Müller, C Seitz, S Wallwiener, T Strowitzki, E Schleussner, U R Markert, V Daniel, B Toth
Peripheral and uterine NK cells (pNK, uNK) can be distinguished according to their receptor expression. Recent studies indicate an association of elevated pNK and uNK with recurrent miscarriage (RM). This study aimed to analyze pNK and uNK in patients with RM and healthy controls. Out of n=590 RM patients screened according to a standard diagnostic protocol, n=268 couples with ≥3 consecutive RM were identified. Subgroups consisted of n=151 primary RM (pRM), n=85 secondary RM (sRM), n=32 tertiary RM (tRM) and n=42 healthy controls...
November 6, 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/27761482/immunology-of-neuromyelitis-optica-during-pregnancy
#2
Vahid Davoudi, Kiandokht Keyhanian, Riley M Bove, Tanuja Chitnis
Anti-aquaporin-4 (AQP4) autoantibody plays a key role in the pathogenesis of neuromyelitis optica (NMO). Studies have shown increased relapse rates in patients with NMO during pregnancy and postpartum. High estrogen levels during pregnancy can increase activation-induced cytidine deaminase expression, which is responsible for immunoglobulin production. Additionally, sex hormones may influence antibody glycosylation, with effects on antibody function. Estrogen decreases apoptosis of self-reactive B cells, through upregulation of antiapoptotic molecules...
December 2016: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/27759445/local-immunity-status-in-patients-with-miscarriages-and-herpetic-infection
#3
N M Mamedalieva, A M Kurmanova, G N Moshkalova, V Kim
A study of the endometrium of women with herpetic infection has shown that early miscarriages (under 12 weeks) occurs as activation of cytotoxic natural killer (NK) cells with CD16 + phenotype and a pronounced suppression level of CD56 + cells endometrial type, and late miscarriages (13-22 weeks of gestation) occurs as cell deficit, followed by reduction of all CD8 + cytotoxic lymphocytes, and of CD56 + and CD16 + NK cells.
October 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27668201/etiologic-characteristics-and-index-pregnancy-outcomes-of-recurrent-pregnancy-losses-in-korean-women
#4
Gi Su Lee, Joon Cheol Park, Jeong Ho Rhee, Jong In Kim
OBJECTIVE: The goal of this study was to evaluate the etiologies and clinical outcomes of Korean recurrent pregnancy loss (RPL) patients. And also, we investigated the differences between primary and secondary RPL patients, between two and three or more pregnancy losses. METHODS: One hundred seventy eight women diagnosed as RPL were enrolled. We performed chromosomal analysis, thyroid stimulating hormone, prolactin, blood glucose, plasminogen activator inhibitor-1, natural killer cell proportion, anticardiolipin antibodies, antiphospholipid antibodies, lupus anticoagulant, anti-β2glycoprotein-1 antibodies, antinuclear antibody, protein C, protein S, antithrombin III, homocysteine, MTFHR gene, factor V Leiden mutation, and hysterosalphingography/hysteroscopic evaluation...
September 2016: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/27527166/transcriptomic-insights-into-the-response-of-placenta-and-decidua-basalis-to-the-cpg-oligodeoxynucleotide-stimulation-in-non-obese-diabetic-mice-and-wild-type-controls
#5
Xiao-Rui Liu, Yu-Na Guo, Chuan-Mei Qin, Xiao-Li Qin, Fei Tao, Fei Su, Fu-Ju Tian, Yan Zhang, Yi Lin
Intrauterine infection is one of the most frequent causes of miscarriage. CpG oligodeoxynucleotide (CpG ODN) can mimic intrauterine infection. CpG ODN-induced embryo-resorption was observed consistently in the NK-cell deficient non-obese diabetic (NOD) mice but not in the wild-type (WT) mice. To elucidate the molecular mechanisms of differential pregnancy outcomes, differentially expressed genes (DEGs) in the placenta and decidua basalis was revealed by RNA-Seq with CpG ODN or control ODN treatment. Common DEGs in the WT and NOD mice were enriched in antimicrobial/antibacterial humoral responses that may be activated as a primary response to bacterial infection...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27324236/a-new-era-in-reproductive-medicine-consequences-of-third-party-oocyte-donation-for-maternal-and-fetal-health
#6
Shigeru Saito, Yasushi Nakabayashi, Akitoshi Nakashima, Tomoko Shima, Osamu Yoshino
The fetus is a semi-allograft for the maternal host in natural pregnancy, but the fetus is a complete allograft after oocyte donation (OD), and there is greater antigenic dissimilarity with the mother. Thus, OD pregnancy is a good model for understanding how the fetus is protected by the maternal immune system. Recent clinical data have revealed a higher risk of miscarriage, gestational hypertension, preterm birth, and low birth weight with OD pregnancy. There is also a higher incidence of chorionic deciduitis, dense fibrinoid deposits in the chorionic basal plate, inflammatory lesions in the chorionic plate, and C4d deposition on syncytiotrophoblasts in OD pregnancy...
June 20, 2016: Seminars in Immunopathology
https://www.readbyqxmd.com/read/27214130/standardisation-of-uterine-natural-killer-unk-cell-measurements-in-the-endometrium-of-women-with-recurrent-reproductive-failure
#7
Gendie E Lash, Judith N Bulmer, Tin Chiu Li, Barbara A Innes, Najat Mariee, Gnyaneshwari Patel, Jean Sanderson, Siobhan Quenby, Susan M Laird
Considerable work is being carried out on endometrial NK cells to determine whether they play a role in successful pregnancy outcome. In addition there is debate about whether measurements of uNK should be included in the clinical assessment for women with recurrent implantation failure or recurrent miscarriage. A hindrance to taking this forward is the fact that the density of uNK cells reported by different centres is very different. The aim of this study was to determine the reason for these differences and to develop a standardised method...
August 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/27198610/%C3%AE-galactosylceramide-activated-murine-nk1-1-invariant-nkt-cells-in-the-myometrium-induce-miscarriages-in-mice
#8
Tomoko Ichikawa, Yasuyuki Negishi, Masumi Shimizu, Toshiyuki Takeshita, Hidemi Takahashi
Innate immunity, which is unable to discriminate self from allo-antigens, is thought to be important players in the induction of miscarriages. Here, we show that the administration of IL-12 to syngeneic-mated C57BL/6 mice on gestation day 7.5 (Gd 7.5), drives significant miscarriages in pregnant females. Furthermore, the administration on Gd 7.5 of α-galactosylceramide (α-GalCer), which is known to activate invariant natural killer T (iNKT) cells, induced miscarriages in both syngeneic-mated C57BL/6 mice and allogeneic-mated mice (C57BL/6 (♀) × BALB/c (♂))...
August 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27156350/polycystic-ovary-syndrome-endometrial-markers
#9
Terhi T Piltonen
Women with polycystic ovarian syndrome (PCOS) present with several endometrial abnormalities possibly explaining some of the adverse endometrium-related outcomes in these women. PCOS and an increased miscarriage rate have been suggested to coincide, but the results are conflicting. Recent studies have also shown increased risks of pregnancy-induced hypertension, preeclampsia, and premature delivery that may be related to altered decidualization/placentation in affected women. In the long run, PCOS per se is associated with the occurrence of endometrial cancer (EC), with obesity aggravating the risk...
April 1, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27048011/intravenous-intralipid-therapy-is-not-beneficial-in-having-a-live-delivery-in-women-aged-40-42-years-with-a-previous-history-of-miscarriage-or-failure-to-conceive-despite-embryo-transfer-undergoing-in-vitro-fertilization-embryo-transfer
#10
J H Check, D L Check
PURPOSE: To evaluate the efficacy of intralipid intravenous infusion in achieving a live pregnancy following IVF--embryo transfer in women of advanced reproductive age (40-42 years). MATERIALS AND METHODS: A matched control was performed. Women aged 40-42 with a previous history of miscarriage or who failed to conceive despite previous embryo transfer who entered an IVF program were offered intravenous intralipid therapy (four ml of 20% liposyn II in 100 ml normal saline over one hour) during the mid-follicular phase...
2016: Clinical and Experimental Obstetrics & Gynecology
https://www.readbyqxmd.com/read/26692771/relationship-between-uterine-natural-killer-cells-and-unexplained-repeated-miscarriage
#11
Mohamed M Farghali, Abdel-Latif G El-Kholy, Khaled H Swidan, Ibrahim A Abdelazim, Ahmed R Rashed, Ezzat El-Sobky, Mostafa F Goma
OBJECTIVE: To evaluate the relation between uterine killer (uK) cells and unexplained repeated miscarriage (RM). MATERIAL AND METHODS: Eighty women with unexplained repeated miscarriage and missed miscarriage of current pregnancy were studied. Fetal viability and gestational age of the current pregnancy were confirmed by ultrasound, followed by suction evacuation to collect abortion specimens and uterine wall curettage to collect decidua specimens. Abortion specimens were collected for long-term monolayer cell culture and subsequent chromosome analysis using conventional G-banding...
2015: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/26677905/progestogens-in-the-prevention-of-miscarriage
#12
Howard J A Carp
Progestational agents are often prescribed to prevent threatened miscarriage progressing to miscarriage, and subsequent miscarriages in recurrent pregnancy loss. Progestogens affect implantation, cytokine balance, natural killer cell activity, arachidonic acid release and myometrial contractility. A recent Cochrane review reported that progestogens were effective for treating threatened miscarriage with no harmful effects on mother or fetus. The results were not statistically different when vaginal progesterone was compared to placebo, (RR=0...
August 1, 2016: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/26398782/menstrual-cycle-distribution-of-uterine-natural-killer-cells-is-altered-in-heavy-menstrual-bleeding
#13
MULTICENTER STUDY
Sourima Biswas Shivhare, Judith N Bulmer, Barbara A Innes, Dharani K Hapangama, Gendie E Lash
Heavy menstrual bleeding (HMB) affects 30% of women of reproductive age and significantly interferes with quality of life. Altered endometrial vascular maturation has been reported in HMB and recurrent miscarriage, the latter associated with increased uterine natural killer (uNK) cell numbers. This study compared endometrial leukocyte populations in controls and women with HMB. Formalin-fixed paraffin-embedded endometrial biopsies from controls (without endometrial pathology) and HMB were immunostained for CD14 (macrophages), CD56 (uNK cells), CD83 (dendritic cells), FOXP3 (regulatory T cells/Tregs), CD3 and CD8 (T cells)...
November 2015: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/26380487/use-of-gammaglobulin-to-lower-elevated-natural-killer-cells-in-patients-with-recurrent-miscarriage
#14
Brian M Cohen, Surekha Machupalli
OBJECTIVE: To evaluate the effectiveness of intravenous immunoglobulin (IVIG) in patients presenting with recurrent miscarriage and abnormally elevated natural killer (NK) cells. STUDY DESIGN: This retrospective patient controlled evidence level II-2 pilot study was conducted at Cohen Center, P.A., Medical City Dallas Hospital. Ninety women with a history of recurrent miscarriage (average, 5) and elevated NK cells were retrospectively evaluated to document the outcome of their treatment with IVIG...
July 2015: Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/25954039/first-do-no-harm-uterine-natural-killer-nk-cells-in-assisted-reproduction
#15
REVIEW
Ashley Moffett, Norman Shreeve
Natural killer (NK) cells are a type of lymphocyte circulating in peripheral blood named because of their effector functions in killing target cells. Immune cells that share similar phenotypic characteristics but are poor killers populate the uterine lining at implantation and during early pregnancy when the placenta is established. The functions of these uterine NK (uNK) cells are essentially unknown but available data point to a role in regulating placentation in concert with other elements of the decidua and invading trophoblast cells...
July 2015: Human Reproduction
https://www.readbyqxmd.com/read/25827646/immunology-and-human-reproduction
#16
REVIEW
Diana Alecsandru, Juan Antonio García-Velasco
PURPOSE OF REVIEW: The immune system's role in recurrent reproductive failure is a controversial issue in assisted reproduction. New insight about maternal tolerance in assisted reproduction has been reported and could explain some of the recurrent miscarriage and/or recurrent implantation failure related causes named until now as unknown. RECENT FINDINGS: Most of the previous studies about immune system implication in reproduction were focused on finding markers on peripheral blood...
June 2015: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/25763390/natural-killer-cells-and-their-activation-status-in-normal-pregnancy
#17
Beatrice Mosimann, Marion Wagner, Hassan Shehata, Leona C Y Poon, Brian Ford, Kypros H Nicolaides, Amolak S Bansal
Increased peripheral blood-activated NK cell counts are associated with increased risk of miscarriage and failed in vitro fertilization treatment. However, assessment of activated peripheral NK cells in normal and pathological pregnancies beyond implantation and early miscarriage has not been described. Total CD69 expressing NK cells counts were measured by flow cytometry in healthy women with singleton pregnancies, including 45 at 11(+6)-13(+6) weeks' gestation, 46 at 20(+0)-22(+4) weeks, and 42 at 31(+6)-33(+5) weeks...
2013: International Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/25747500/medium-dose-intravenous-immunoglobulin-therapy-for-women-with-six-or-more-recurrent-miscarriages
#18
Hideto Yamada, Masashi Deguchi, Yoko Maesawa, Yuki Nakajima, Yukari Nishino, Kenji Tanimura, Yasuhiko Ebina
This study aimed to evaluate changes in natural killer (NK) cell activity and the percentage of monocytes in women with recurrent miscarriage who received medium-dose intravenous immunoglobulin (IVIg) therapy. Fourteen women with a history of six or more recurrent miscarriages of unexplained etiology received 60-g IVIg therapy (20 g daily, for three days) during early gestation. NK cell activity in the peripheral blood decreased to 12% one week after therapy compared with before therapy (median, 22%, P < 0...
June 2015: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/25713505/immune-cells-in-the-female-reproductive-tract
#19
REVIEW
Sung Ki Lee, Chul Jung Kim, Dong-Jae Kim, Jee-Hyun Kang
The female reproductive tract has two main functions: protection against microbial challenge and maintenance of pregnancy to term. The upper reproductive tract comprises the fallopian tubes and the uterus, including the endocervix, and the lower tract consists of the ectocervix and the vagina. Immune cells residing in the reproductive tract play contradictory roles: they maintain immunity against vaginal pathogens in the lower tract and establish immune tolerance for sperm and an embryo/fetus in the upper tract...
February 2015: Immune Network
https://www.readbyqxmd.com/read/25681385/recurrent-miscarriage-causes-evaluation-and-management
#20
REVIEW
Carmen Garrido-Gimenez, Jaume Alijotas-Reig
Recurrent miscarriage is frustrating for the physician and a heartbreaking experience for the patient. Approximately 5% of couples trying to conceive have two consecutive miscarriages. Despite a thorough study of patients, the aetiology of this common obstetric complication is unknown in 50% of cases. Known causes include abnormal chromosomes, endocrinological disorders and uterine abnormalities. Although antiphospholipid antibodies have been demonstrated in miscarriages, the role played by alloimmune mechanisms remains unclear...
March 2015: Postgraduate Medical Journal
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