Hideto Yamada, Masashi Deguchi, Shigeru Saito, Toshiyuki Takeshita, Mari Mitsui, Tsuyoshi Saito, Takeshi Nagamatsu, Koichi Takakuwa, Mikiya Nakatsuka, Satoshi Yoneda, Katsuko Egashira, Masahito Tachibana, Keiichi Matsubara, Ritsuo Honda, Atsushi Fukui, Kanji Tanaka, Kazuo Sengoku, Toshiaki Endo, Hiroaki Yata
The aim was to evaluate whether natural killer (NK) cells and regulatory T (Treg) cells were involved in mechanisms underlying beneficial effects of a high dose of intravenous immunoglobulin (IVIG) on recurrent pregnancy losses (RPL) of unexplained etiology. In a double-blind, randomized, placebo-controlled trial of IVIG (400 mg/kg, for 5 days in 4-6 weeks of gestation) in women with RPL, blood samples were collected pre-infusion, one week after infusion (1 w), and eight weeks of gestation/when miscarried (8 w)...
June 14, 2023: Journal of Reproductive Immunology