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IgM dengue serology

Jasmine Porwal, Ajay Chauhan
Dengue infection accompanied by unusual complications and manifestations has been described before. Here we report a case of dengue encephalitis who was IgM positive for dengue serology and had presented to us with only motor weakness after an acute febrile episode. Dengue presenting as encephalitis is in itself a very rare feature and that too, pure motor weakness has hardly ever been reported before.
August 2016: Journal of the Association of Physicians of India
P Padmapriya, V Senthil Kumar, R Senthil Raja, A Khaleefathullah Sheriff, T S Uma, S Mohana, Kavita Arunagiri, A Anupama, N Saran, R Kiruba, K Saravana Murali, B V Suresh Babu, N Nivas Chakravarthy, K Saraswathi, K Kaveri, P Gunasekaran
Dengue is a public health problem with an increasing global incidence and geographic distribution in almost all tropical and subtropical countries, with a transition from epidemic to endemic occurrence. In this study, we report a six-year analysis (2009-2014) performed at the Department of Virology, King Institute of Preventive Medicine, Chennai, Tamil Nadu, India. Our data confirm earlier findings that dengue is highly endemic in Chennai. In the present study, 10,099 serum samples from suspected dengue cases were tested for IgM ELISA (NIV Capture) and IgG Panbio ELISA (Australia)...
September 30, 2016: Archives of Virology
Anna Likos, Isabel Griffin, Andrea M Bingham, Danielle Stanek, Marc Fischer, Stephen White, Janet Hamilton, Leah Eisenstein, David Atrubin, Prakash Mulay, Blake Scott, Patrick Jenkins, Danielle Fernandez, Edhelene Rico, Leah Gillis, Reynald Jean, Marshall Cone, Carina Blackmore, Janet McAllister, Chalmers Vasquez, Lillian Rivera, Celeste Philip
During the first 6 months of 2016, large outbreaks of Zika virus disease caused by local mosquito-borne transmission occurred in Puerto Rico and other U.S. territories, but local mosquito-borne transmission was not identified in the continental United States (1,2). As of July 22, 2016, the Florida Department of Health had identified 321 Zika virus disease cases among Florida residents and visitors, all occurring in either travelers from other countries or territories with ongoing Zika virus transmission or sexual contacts of recent travelers...
2016: MMWR. Morbidity and Mortality Weekly Report
A Kuna, M Bykowska, N Kulawiak, B Biernat, B Szostakowska, W L Nahorski, W Pawlowski, L Chomicz
BACKGROUND & OBJECTIVES: Dengue is a mosquito-borne viral disease, incidences of which have increased rapidly in the past decade. About 400 million new infections are recorded annually worldwide, and 40% of the human population lives in the areas at risk of dengue transmission. In this study, the clinical and laboratory profile of dengue diagnosed patients returning to Poland from tropical areas has been analyzed. METHODS: This is a retrospective study of 65 patients based on clinical symptoms and serological tests conducted in the Department of Tropical Parasitology of Institute of Maritime and Tropical Medicine (IMTM) in Gdynia, Poland during 2010-15...
July 2016: Journal of Vector Borne Diseases
Fernando Rosso, Sara Vanegas, Sarita Rodríguez, Robinson Pacheco
INTRODUCTION: Little is known about the prevalence and clinical course of dengue infection in elderly patients living in endemic areas; it is presumed that there is a lower prevalence but higher severity, complications and mortality.  OBJECTIVE: To describe the prevalence and clinical course of dengue infection in elderly patients who were admitted to a referral care center for infectious diseases in an endemic region.  MATERIALS AND METHODS: We conducted an observational and descriptive study between 2011 and 2014, using a cohort of elderly patients with serological diagnosis of dengue...
2016: Biomédica: Revista del Instituto Nacional de Salud
Sriram Pothapregada, Banupriya Kamalakannan, Mahalaskhmy Thulasingham, Srinivasan Sampath
OBJECTIVE: To study the clinical profile and outcome of dengue fever in children at a tertiary care hospital in Puducherry. MATERIALS AND METHODS: All children (0-12 years of age) diagnosed and confirmed as dengue fever from August 2012 to January 2015 were reviewed retrospectively from hospital case records as per the revised World Health Organization guidelines for dengue fever. The diagnosis was confirmed by NS1 antigen-based ELISA test or dengue serology for IgM and IgG antibodies, and the data were analyzed using SPSS 16...
July 2016: Journal of Global Infectious Diseases
Li Ting Soh, Raynal C Squires, Li Kiang Tan, Kwoon Yong Pok, HuiTing Yang, Christina Liew, Aparna Singh Shah, John Aaskov, Sazaly Abubakar, Futoshi Hasabe, Lee Ching Ng, Frank Konings
OBJECTIVE: To conduct an external quality assessment (EQA) of dengue and chikungunya diagnostics among national-level public health laboratories in the Asia Pacific region following the first round of EQA for dengue diagnostics in 2013. METHODS: Twenty-four national-level public health laboratories performed routine diagnostic assays on a proficiency testing panel consisting of two modules. Module A contained serum samples spiked with cultured dengue virus (DENV) or chikungunya virus (CHIKV) for the detection of nucleic acid and DENV non-structural protein 1 (NS1) antigen...
April 2016: Western Pacific Surveillance and Response Journal: WPSAR
Mauro Jorge Cabral-Castro, Marta Guimarães Cavalcanti, Regina Helena Saramago Peralta, José Mauro Peralta
BACKGROUND: Arboviruses are important emerging viruses worldwide. The signs and symptoms of Zika virus (ZIKV) infection are similar to those presented by infections with dengue virus (DENV) and chikungunya virus (CHIKV). Furthermore, diagnosis of ZIKV infection is particularly challenging in dengue endemic regions and with co-circulation of DENV, CHIKV, and ZIKV, making diagnosis based solely on clinical and epidemiological data unreliable. As these three viral infections share similar clinical manifestations, differential diagnosis is crucial...
September 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Christian Therrien, Guillaume Jourdan, Kimberly Holloway, Cécile Tremblay, Michael A Drebot
This is the first Canadian case of Chikungunya virus (CHIKV) infection reported in a traveller returning from the Caribbean. Following multiple mosquito bites in Martinique Island in January 2014, the patient presented with high fever, headaches, arthralgia on both hands and feet, and a rash on the trunk upon his return to Canada. Initial serological testing for dengue virus infection was negative. Support therapy with nonsteroidal anti-inflammatory drugs was administered. The symptoms gradually improved 4 weeks after onset with residual arthralgia and morning joint stiffness...
2016: Canadian Journal of Infectious Diseases & Medical Microbiology
Jo Ee Sam, Teak Sheng Gee, Abdul Wahab Nasser
INTRODUCTION: Dengue fever is a global pandemic threat with increasing incidence. To date, there are no cures and the effectiveness of dengue vaccines is still uncertain. World Heath Organization introduced expanded dengue syndrome to include unusual presentations of dengue fever including severe neurologic complications. One of the deadly complications is intracranial hemorrhage (ICH). METHODOLOGY: We collected data of patients with ICH diagnosed via a plain computed tomography of the brain (CT brain) with thrombocytopenia and positive Dengue virus type 1 nonstructural protein (NS1) antigen test or positive dengue serology IgM from January 2014 till June 2015 at our center...
July 2016: Journal of Neurosciences in Rural Practice
Sotianingsih Haryanto, Rahma F Hayati, Benediktus Yohan, Lanceria Sijabat, Ifo F Sihite, Sukmal Fahri, Febrina Meutiawati, Jonathan A N Halim, Stefanie N Halim, Amin Soebandrio, R Tedjo Sasmono
Dengue is hyperendemic in Indonesia. In 2015, reported cases of dengue fever doubled those of 2014 in the Jambi municipality of Sumatra. We examined viral aetiology and its relationship with disease outcome in Jambi. Dengue-suspected patients' sera were collected and NS1 detection and IgM/IgG serology were performed. Dengue virus (DENV) serotyping was performed using real-time RT-PCR. Envelope genes were sequenced to determine the genotypes of DENV. Clinical, haematologic, and demographic data were recorded...
May 2016: Pathogens and Global Health
Sriram Pothapregada, Banupriya Kamalakannan, Mahalakshmy Thulasingam, Srinivasan Sampath
INTRODUCTION: Dengue fever is a major public health problem worldwide. The 2011 revised World Health Organization (WHO) guidelines have emphasized on early diagnosis and intervention to reduce the case fatality rate due to dengue fever. Rapid diagnostic tests like NS1 antigen assays have improved the detection of cases in early clinical phase of illness but its role as a predictor of severe dengue infection is not very clear. AIM: To evaluate the utility of NS1 Ag assay as an early diagnostic marker and predictor of severe dengue infection...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
Chuan Hun Ding, Zetti Zainol Rashid, Md Mostafizur Rahman, NanFeng Khang, Wan Ngor Low, Nurabrar Hussin, Melissa Iqlima Marzuki, Alyaa Nadhira Jaafar, Nurul Ain' Nabilla Roslan, Terukumar Chandrasekaran
OBJECTIVES: The aims of this study were to determine the seroprevalence of acute dengue in Universiti Kebangsaan Malaysia (UKM) Medical Centre and its correlation with selected haematological and biochemical parameters. METHODS: This cross-sectional study was conducted from January to June 2015. A patient was serologically diagnosed with acute dengue if the dengue virus IgG, IgM or NS-1 antigen was reactive. RESULTS: Out of 1,774 patients suspected to have acute dengue, 1,153 were serologically diagnosed with the infection, resulting in a seroprevalence of 64...
March 2016: Pakistan Journal of Medical Sciences Quarterly
Mya Myat Ngwe Tun, Aung Kyaw Kyaw, Nader Makki, Rohitha Muthugala, Takeshi Nabeshima, Shingo Inoue, Daisuke Hayasaka, Meng Ling Moi, Corazon C Buerano, Saw Myat Thwe, Kyaw Zin Thant, Kouichi Morita
In 2013 in Myanmar, dengue epidemic occurred with 20,255 cases including 84 deaths. This study aimed to determine the serological and molecular characteristics of dengue virus (DENV) infection among children with clinical diagnosis of dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS) during this period. Single acute serum samples were collected from 300 children in Mandalay Children Hospital, Mandalay, Myanmar. Out of the 300 children, 175 (58.3%) and 183 (61%) were positive for anti-dengue IgM and anti-dengue IgG, respectively...
September 2016: Infection, Genetics and Evolution
Eric Plennevaux, Arunee Sabchareon, Kriengsak Limkittikul, Pornthep Chanthavanich, Chukiat Sirivichayakul, Annick Moureau, Mark Boaz, T Anh Wartel, Melanie Saville, Alain Bouckenooghe
BACKGROUND: Dengue diagnosis confirmation and surveillance are widely based on serological assays to detect anti-dengue IgM or IgG antibodies since such tests are affordable/user-friendly. The World Health Organization identified serological based diagnosis as a potential tool to define probable dengue cases in the context of vaccine trials, while acknowledging that this may have to be interpreted with caution. METHODS: In a phase IIb randomized, placebo-controlled trial assessing the efficacy of a tetravalent dengue vaccine (CYD-TDV) in Thai schoolchildren, case definition was based on virological confirmation by either serotype-specific RT-PCRs or by NS1-antigen ELISA (Clinicaltrials...
May 23, 2016: Vaccine
Sopheak Hem, Sowath Ly, Irene Votsi, Florian Vogt, Nima Asgari, Philippe Buchy, Seiha Heng, Mathieu Picardeau, Touch Sok, Sovann Ly, Rekol Huy, Bertrand Guillard, Simon Cauchemez, Arnaud Tarantola
BACKGROUND: Leptospirosis is an emerging but neglected public health challenge in the Asia/Pacific Region with an annual incidence estimated at 10-100 per 100,000 population. No accurate data, however, are available for at-risk rural Cambodian communities. METHOD: We conducted anonymous, unlinked testing for IgM antibodies to Leptospira spp. on paired sera of Cambodian patients <20 years of age between 2007-2009 collected through active, community-based surveillance for febrile illnesses in a convenience sample of 27 rural and semi-rural villages in four districts of Kampong Cham province, Cambodia...
2016: PloS One
Thamarasi Senaratne, Harith Wimalaratne, D G S Alahakoon, Nirmali Gunawardane, Jillian Carr, Faseeha Noordeen
Dengue virus (DENV) infections are increasing with respect to incidence and severity in the Central Province of Sri Lanka. The objective of this study was to define the clinical, immunological, and virological profiles of patients admitted to the General Hospital, Kandy with clinically apparent dengue. Demographic, clinical, hematological parameters, liver enzymes (ALT and AST), and blood samples were collected from 292 patients with fever <5 days post onset and fulfilling the WHO criteria for the diagnosis of dengue fever/dengue hemorrhagic fever (DF/DHF)...
October 2016: Journal of Medical Virology
Francisco J Carod-Artal
INTRODUCTION: The current epidemic outbreak due to Zika virus began in 2015 and since then it has been reported in 31 countries and territories in America. The epidemiological and clinical aspects related to infection by Zika virus are reviewed. DEVELOPMENT: Since 2007, 55 countries in America, Asia, Africa and Oceania have detected local transmission of the virus. This epidemic has affected almost 1.5 million people in Brazil. 80% of the cases are asymptomatic...
April 1, 2016: Revista de Neurologia
Cristina Bocanegra, Andrés Antón, Elena Sulleiro, Diana Pou, Fernando Salvador, Silvia Roure, Laura Gimferrer, Mateu Espasa, Leticia Franco, Israel Molina, Lluís Valerio
BACKGROUND: The Chikungunya virus (CKIKV) is currently present in America. Travel between America and Europe is particularly intense and one of the main vectors of CHIKV, Aedes albopictus, is well established in the Mediterranean basin. We describe a series of imported cases that could originate a European outbreak. METHODS: We retrospectively studied cases of CHIKV originating in America and diagnosed in the last year in three Tropical Medicine Units of Barcelona of the International Health Program of the Catalan Health Institute (PROSICS)...
March 2016: Journal of Travel Medicine
Souren Pal, Kaushik Sen, Nirendra Mohan Biswas, Anirban Ghosal, S K Rousan Jaman, K Y Yashavantha Kumar
BACKGROUND AND OBJECTIVE: Dengue, an acute viral disease, transmitted by Aedes mosquitoes, has a variable clinical spectrum ranging from asymptomatic infection to life-threatening dengue hemorrhagic fever and dengue shock syndrome. However, neurological complications, in general, are unusual but have been observed more frequently in the recent past, and some studies highlighted varied neurological complications during the course of illness. Although dengue is classically considered a nonneurotropic virus, there is increasing evidence for dengue viral neurotropism...
January 2016: Journal of Neurosciences in Rural Practice
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