Xiaohong Liu, Hefeng Chen, Guangqiang Ye, Hongyang Liu, Chunying Feng, Weiye Chen, Liang Hu, Qiongqiong Zhou, Zhaoxia Zhang, Jiangnan Li, Xianfeng Zhang, Xijun He, Yuntao Guan, Zhengshuang Wu, Dongming Zhao, Zhigao Bu, Changjiang Weng, Li Huang
African swine fever (ASF) is an acute, hemorrhagic, and severe infectious disease caused by the ASF virus (ASFV). ASFV has evolved multiple strategies to escape host antiviral immune responses. Here, we reported that ASFV pB318L, a trans-geranylgeranyl-diphosphate synthase, reduced the expression of type I interferon (IFN-I) and IFN-stimulated genes (ISGs). Mechanically, pB318L not only interacted with STING to reduce the translocation of STING from the endoplasmic reticulum to the Golgi apparatus but also interacted with IFN receptors to reduce the interaction of IFNAR1/TYK2 and IFNAR2/JAK1...
April 2024: PLoS Pathogens