keyword
https://read.qxmd.com/read/38633105/profile-of-patients-with-maxillofacial-space-infections-and-associated-risk-factors
#21
JOURNAL ARTICLE
Srikanth Gadicherla, Kirti Manglani, Kalyana C Pentapati, Adarsh Kudva, Chithra Aramanadka, Rajaji Chandravel
OBJECTIVE: To evaluate the profile of patients operated for maxillofacial space infections and associated risk factors for the length of hospital stay. MATERIALS AND METHODS: We conducted a retrospective study among patients operated for maxillofacial infections at our center from 2010 to 2020. Information collected from the records were age, sex, type and number of spaces involved, clinical signs and symptoms (pain, swelling, toothache, sore throat, otalgia, hoarseness, headache, cough, neck swelling, rancid breath, sialorrhea, gingival swelling, muffled voice, trismus, fever, dysphagia, odynophagia, malaise, lymphadenopathy, dyspnoea, pus discharge), treatment modality, total leukocyte count, evidence of bacterial growth, comorbidities, complications if any and length of hospital stay...
2024: TheScientificWorldJournal
https://read.qxmd.com/read/38632892/the-effect-of-osteopathic-manipulative-treatment-on-quality-of-life-in-patients-with-cardiac-implantable-electronic-devices
#22
JOURNAL ARTICLE
Jacqueline Nikakis, Ermin Tale, Denis Malkov, Uddampreet S Arora, Jordan Keys, To Shan Li, Sheldon C Yao, Todd J Cohen
CONTEXT: Osteopathic manipulative treatment (OMT) has been demonstrated to have an effect on the autonomic nervous system, which may have antiarrhythmic effects. The effects of OMT in patients with cardiac implantable electronic devices (CIEDs) have not previously been reported. This study investigated the impact of OMT on quality of life (QOL) in this patient population. OBJECTIVES: The purpose of this study is to investigate the effects of OMT on QOL in CIED patients...
April 19, 2024: Journal of osteopathic medicine
https://read.qxmd.com/read/38632711/current-state-of-theranostics-in-metastatic-castrate-resistant-prostate-cancer
#23
JOURNAL ARTICLE
Udit Nindra, Peter Lin, Therese Becker, Tara L Roberts, Wei Chua
Prostate cancer remains one of the leading causes of cancer-related death in the world. There have been significant advances in chemotherapy, hormonal therapy and targeted therapy options for patients with castrate-resistant disease. However, these systemic treatments are often associated with unwanted toxicities. Targeted therapy with radiopharmaceuticals has become of key interest to limit systemic toxicity and provides a more precision oncology approach to treatment. Strontium-89, Samarium-153 EDTMP and Radium-223 have been trialled with mixed results...
April 17, 2024: Journal of Medical Imaging and Radiation Oncology
https://read.qxmd.com/read/38632388/multi-ancestry-meta-analysis-of-tobacco-use-disorder-identifies-461-potential-risk-genes-and-reveals-associations-with-multiple-health-outcomes
#24
JOURNAL ARTICLE
Sylvanus Toikumo, Mariela V Jennings, Benjamin K Pham, Hyunjoon Lee, Travis T Mallard, Sevim B Bianchi, John J Meredith, Laura Vilar-Ribó, Heng Xu, Alexander S Hatoum, Emma C Johnson, Vanessa K Pazdernik, Zeal Jinwala, Shreya R Pakala, Brittany S Leger, Maria Niarchou, Michael Ehinmowo, Greg D Jenkins, Anthony Batzler, Richard Pendegraft, Abraham A Palmer, Hang Zhou, Joanna M Biernacka, Brandon J Coombes, Joel Gelernter, Ke Xu, Dana B Hancock, Nancy J Cox, Jordan W Smoller, Lea K Davis, Amy C Justice, Henry R Kranzler, Rachel L Kember, Sandra Sanchez-Roige
Tobacco use disorder (TUD) is the most prevalent substance use disorder in the world. Genetic factors influence smoking behaviours and although strides have been made using genome-wide association studies to identify risk variants, most variants identified have been for nicotine consumption, rather than TUD. Here we leveraged four US biobanks to perform a multi-ancestral meta-analysis of TUD (derived via electronic health records) in 653,790 individuals (495,005 European, 114,420 African American and 44,365 Latin American) and data from UK Biobank (ncombined  = 898,680)...
April 17, 2024: Nature Human Behaviour
https://read.qxmd.com/read/38631936/coronary-microvascular-disease-registry-cmdr-study-design-and-rationale
#25
JOURNAL ARTICLE
Brian C Case, Ilan Merdler, Giorgio A Medranda, Cheng Zhang, Sevket Tolga Ozturk, Vaishnavi Sawant, Hector M Garcia-Garcia, Lowell F Satler, Itsik Ben-Dor, Hayder D Hashim, Ron Waksman
BACKGROUND: Coronary microvascular dysfunction (CMD) is a prevalent condition among patients with cardiovascular risk factors, leading to a reduced quality of life and an increased risk of major adverse cardiovascular events. Novel invasive techniques have emerged to more accurately diagnose CMD. However, CMD's natural history remains poorly understood due to limited data. To address this knowledge gap, the Coronary Microvascular Disease Registry (CMDR) was established with the primary aim of standardizing comprehensive coronary functional testing and understanding of CMD...
March 27, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://read.qxmd.com/read/38631856/a-case-of-adult-onset-still-s-disease-aosd-with-gastrointestinal-lesions
#26
JOURNAL ARTICLE
Takahito Harada, Yoshikazu Hirata, Hayato Kawamura, Yuki Yamamoto, Yuka Kobayashi, Daisuke Kumai, Akihisa Adachi, Yoshihito Nagura, Hirokazu Ikeuchi, Noriyuki Hayashi, Hiroki Takada, Satoshi Sobue, Megumi Yoshida
A 51-year-old woman with fever was admitted to our hospital. A computed tomography (CT) scan showed thickened colonic walls. Colonoscopy revealed erosion in the ileum and colon. Adult-onset Still's disease (AOSD) was diagnosed due to a subsequent sore throat and skin rash. Following AOSD treatment, methylprednisolone pulse therapy, followed by prednisolone and cyclosporine, was initiated. Despite achieving a temporary improvement, relapse occurred with fever, abdominal pain, with worsening CT and endoscopic findings...
April 16, 2024: Internal Medicine
https://read.qxmd.com/read/38631853/acute-onset-of-constrictive-pericarditis-due-to-acute-myelomonocytic-leukemia-a-case-and-literature-review
#27
JOURNAL ARTICLE
Naoki Kosaka, Takanori Uchiyama, Masahiro Onozawa, Jun Nagai, Jiro Koya, Suguru Ishizaka, Toshiyuki Nagai, Yohei Ikebe, Kenjiro Kato, Zen-Ichi Tanei, Jun Sakakibara-Konishi, Yuta Hasegawa, Hiroyuki Ohigashi, Hideki Goto, Daigo Hashimoto, Hideki Ujiie, Satoshi Hirano, Satoshi Konno, Toshihisa Anzai, Koji Taniguchi, Shinya Tanaka, Takanori Teshima
We herein present a fatal case of constrictive pericarditis (CP) due to acute myelomonocytic leukemia (AMML) in a patient who initially complained of an acute onset of chest pain two days after COVID-19 vaccination. An autopsy revealed pericardial infiltration of leukemic cells. CP is rarely associated with leukemia and only 14 cases have been reported in the literature. The etiology of CP in previous reports included leukemic infiltration, graft-versus-host disease, drug-induced, post-radiation, autoimmune, and otherwise unidentified...
April 16, 2024: Internal Medicine
https://read.qxmd.com/read/38631839/defining-predictors-of-responsiveness-to-advanced-therapies-in-crohn-s-disease-and-ulcerative-colitis-protocol-for-the-ibd-response-and-nested-cd-metaresponse-prospective-multicentre-observational-cohort-study-in-precision-medicine
#28
JOURNAL ARTICLE
Nicola J Wyatt, Hannah Watson, Carl A Anderson, Nicholas A Kennedy, Tim Raine, Tariq Ahmad, Dean Allerton, Michelle Bardgett, Emma Clark, Dawn Clewes, Cristina Cotobal Martin, Mary Doona, Jennifer A Doyle, Katherine Frith, Helen C Hancock, Ailsa L Hart, Victoria Hildreth, Peter M Irving, Sameena Iqbal, Ciara Kennedy, Andrew King, Sarah Lawrence, Charlie W Lees, Robert Lees, Laura Letchford, Trevor Liddle, James O Lindsay, Rebecca H Maier, John C Mansfield, Julian R Marchesi, Naomi McGregor, Rebecca E McIntyre, Jasmin Ostermayer, Tolulope Osunnuyi, Nick Powell, Natalie J Prescott, Jack Satsangi, Shriya Sharma, Tara Shrestha, Ally Speight, Michelle Strickland, James Ms Wason, Kevin Whelan, Ruth Wood, Gregory R Young, Xinyue Zhang, Miles Parkes, Christopher J Stewart, Luke Jostins-Dean, Christopher A Lamb
INTRODUCTION: Characterised by chronic inflammation of the gastrointestinal tract, inflammatory bowel disease (IBD) symptoms including diarrhoea, abdominal pain and fatigue can significantly impact patient's quality of life. Therapeutic developments in the last 20 years have revolutionised treatment. However, clinical trials and real-world data show primary non-response rates up to 40%. A significant challenge is an inability to predict which treatment will benefit individual patients...
April 17, 2024: BMJ Open
https://read.qxmd.com/read/38631837/prevalence-of-work-related-musculoskeletal-disorders-and-associated-factors-affecting-emergency-medical-services-professionals-in-jordan-a-cross-sectional-study
#29
JOURNAL ARTICLE
Mohammad S Nazzal, Alaa O Oteir, Ahmad Alrawashdeh, Mahmoud T Alwidyan, Qussai Obiedat, Khader A Almhdawi, Noor T Ismael, Brett Williams
OBJECTIVES: Emergency medical services (EMSs) personnel are at high risk for developing work-related musculoskeletal disorders (WMSDs). However, no studies have yet investigated the prevalence and effect of these disorders on the Jordanian EMS personnel. Therefore, this study aimed to determine the prevalence of WMSDs among Jordanian EMS personnel and its associated factors. DESIGN: This study used a cross-sectional design. Participants were asked to complete a self-administrated and validated questionnaire to measure the WMSDs, including a demographic survey and the Nordic Musculoskeletal Questionnaire...
April 17, 2024: BMJ Open
https://read.qxmd.com/read/38631836/scoping-review-of-interventions-to-de-implement-potentially-harmful-non-steroidal-anti-inflammatory-drugs-nsaids-in-healthcare-settings
#30
JOURNAL ARTICLE
Michelle S Rockwell, Emma G Oyese, Eshika Singh, Matthew Vinson, Isaiah Yim, Jamie K Turner, John W Epling
OBJECTIVES: Potentially harmful non-steroidal anti-inflammatory drugs (NSAIDs) utilisation persists at undesirable rates worldwide. The purpose of this paper is to review the literature on interventions to de-implement potentially harmful NSAIDs in healthcare settings and to suggest directions for future research. DESIGN: Scoping review. DATA SOURCES: PubMed, CINAHL, Embase, Cochrane Central and Google Scholar (1 January 2000 to 31 May 2022)...
April 17, 2024: BMJ Open
https://read.qxmd.com/read/38631833/short-duration-aerobic-high-intensity-intervals-versus-moderate-exercise-training-intensity-in-patients-with-peripheral-artery-disease-study-protocol-for-a-randomised-controlled-trial-the-angiof-hiit-study
#31
JOURNAL ARTICLE
Stefano Lanzi, Anina Pousaz, Marco Fresa, Cyril Besson, Benoit Desgraz, Vincent Gremeaux-Bader, Lucia Mazzolai
INTRODUCTION: Supervised exercise training is among the first-line therapies for patients with peripheral artery disease (PAD). Current recommendations for exercise include guidance focusing on claudication pain, programme and session duration, and frequency. However, no guidance is offered regarding exercise training intensity. This study aims to compare the effects of 12-week-long supervised walking exercise training (high-intensity interval training (HIIT) vs moderate-intensity exercise (MOD)) in patients with chronic symptomatic PAD...
April 17, 2024: BMJ Open
https://read.qxmd.com/read/38631813/novel-genetic-variant-in-hereditary-spastic-paraparesis
#32
JOURNAL ARTICLE
Kathryn A W Knight, Catriona Barbour-Hastie, Angus Gane, Jonathan O'Riordan
A man in his 30s was referred to neurology with right-sided paraesthesia, tremors, chest pain and lower urinary tract and erectile dysfunction. He had a medical history of left acetabular dysplasia, and subjective memory impairment, the latter being in the context of depression and chronic pain with opioid use. There was no notable family history. On examination, he had a spastic paraparesis. Imaging revealed atrophy of the thoracic spine. Lumbar puncture demonstrated a raised protein but other constituents were normal, including no presence of oligoclonal bands...
April 17, 2024: BMJ Case Reports
https://read.qxmd.com/read/38631486/longistylin-a-from-cajanus-cajan-l-millsp-disturbs-glycerophospholipid-metabolism-and-cytokinin-biosynthesis-of-nocardia-seriolae
#33
JOURNAL ARTICLE
Liyun Zhao, Liyuan Yao, Meilan Liu, Silin Qiu, Jiani He, Jindong Lin, Zhengguo Tao, Yu Lu, Shulin Deng, Hongfeng Chen, Sheng-Xiang Qiu
ETHNOPHARMACOLOGICAL RELEVANCE: Nocardiosis is an uncommon infectious disease that bears certain similarities to tuberculosis, with a continuous increase in its incidence and a poor prognosis. In traditional Chinese medicine, the leaves of Cajanus cajan (L.) Millsp. are employed to treat wounds, malaria, coughs, and abdominal pain. AIM OF THE STUDY: In this study, we investigated the effects and mechanisms of longistylin A (LGA), a natural stilbene isolated from C...
April 15, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38630956/incomplete-spinal-cord-injury-with-persistent-neuropathic-pain-secondary-to-iatrogenic-epidural-hematoma-a-clinical-vignette
#34
JOURNAL ARTICLE
Robert A Churchill, Melanie J White, Nick C Canzanello, Ronald K Reeves, Marianne T Luetmer
No abstract text is available yet for this article.
April 1, 2024: American Journal of Physical Medicine & Rehabilitation
https://read.qxmd.com/read/38630921/the-relationship-of-body-mass-index-on-patient-reported-outcomes-after-platelet-rich-plasma-versus-microfragmented-adipose-tissue-for-knee-osteoarthritis-a-secondary-analysis-of-a-randomized-controlled-trial
#35
JOURNAL ARTICLE
Michael Baria, Reshma George, Tyler Barker, David Flanigan, Christopher Kaeding, Robert Magnussen
OBJECTIVE: Body mass index (BMI) is known to contribute to outcomes for patients with knee OA. Furthermore, BMI influences the protein expression of orthobiologic treatments like platelet-rich plasma (PRP) and microfragmented adipose tissue (MFAT). We performed a secondary analysis of the association of BMI with PROs for patients with knee OA who received either PRP or MFAT injections. METHODS: Seventy-one patients with knee OA were randomized to receive a single ultrasound-guided injection of PRP or MFAT...
April 1, 2024: American Journal of Physical Medicine & Rehabilitation
https://read.qxmd.com/read/38630850/nociceptor-spontaneous-activity-is-responsible-for-fragmenting-non-rapid-eye-movement-sleep-in-mouse-models-of-neuropathic-pain
#36
JOURNAL ARTICLE
Chloe Alexandre, Giulia Miracca, Victor Duarte Holanda, Ashley Sharma, Kamila Kourbanova, Ashley Ferreira, Maíra A Bicca, Xiangsunze Zeng, Victoria A Nassar, Seungkyu Lee, Satvinder Kaur, Sridevi V Sarma, Pierre Sacré, Thomas E Scammell, Clifford J Woolf, Alban Latremoliere
Spontaneous pain, a major complaint of patients with neuropathic pain, has eluded study because there is no reliable marker in either preclinical models or clinical studies. Here, we performed a comprehensive electroencephalogram/electromyogram analysis of sleep in several mouse models of chronic pain: neuropathic (spared nerve injury and chronic constriction injury), inflammatory (Freund's complete adjuvant and carrageenan, plantar incision) and chemical pain (capsaicin). We find that peripheral axonal injury drives fragmentation of sleep by increasing brief arousals from non-rapid eye movement sleep (NREMS) without changing total sleep amount...
April 17, 2024: Science Translational Medicine
https://read.qxmd.com/read/38630838/effect-of-extracorporeal-shock-wave-on-upper-trapezius-trigger-points-in-patients-with-cervicogenic-headache-a-randomized-clinical-trial
#37
JOURNAL ARTICLE
Radwa F Hammam, Ahmed M Alshimy, Omar M Elabd, Aliaa M Elabd
OBJECTIVE: A recent study was designed to ascertain the impact of extracorporeal shock wave therapy (ESWT) on upper trapezius trigger points in cervicogenic headaches patients. DESIGN: A double-blinded randomized controlled trial study, in which 50 participants (11 male and 39 female) aged between 20-40 with cervicogenic headache were subdivided with randomization to group (A), which received traditional physical therapy and sham shock wave therapy, and group (B), which received traditional physical therapy and actual shock wave therapy...
April 4, 2024: American Journal of Physical Medicine & Rehabilitation
https://read.qxmd.com/read/38630735/clinical-value-of-questionnaires-physical-tests-for-patellofemoral-pain-validity-reliability-and-predictive-capacity
#38
JOURNAL ARTICLE
Gema Chamorro-Moriana, Fernando Espuny-Ruiz, Carmen Ridao-Fernández, Eleonora Magni
OBJECTIVES: To determine the most appropriate method of functional assessment for "patellofemoral pain" (PFP)/"chondromalacia patella" for its diagnostic value, (validity, reliability, sensitivity, specificity, predictive value and clinical applicability); to outline initial interpretations of the questionnaires and their appropriateness, through the cut-off points determined in their scores based on physical test and Magnetic Resonance Imaging (MRI); to establish which methods should be used in conjunction with each other to obtain clinical diagnoses that are robust effective and efficient...
2024: PloS One
https://read.qxmd.com/read/38630668/improving-immersive-experiences-in-virtual-natural-setting-for-public-health-and-environmental-design-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#39
JOURNAL ARTICLE
Yuhan Wen, Xiwei Shen, Yan Shen
In recent years, virtual reality (VR) technology has emerged as a powerful tool in the field of therapeutic landscapes. For hospitalized patients or individuals with limited mobility, VR provides highly personalized therapy by simulating authentic natural environments within a safe, convenient, and engaging setting. This study investigated the effectiveness of immersing patients in virtual natural environments for health recovery and compared the varying impacts of different types of landscapes on patients' recovery levels...
2024: PloS One
https://read.qxmd.com/read/38630557/tnfaip8-and-tipe2-gene-deletion-ameliorates-immediate-proteoglycan-loss-and-inflammatory-responses-in-the-injured-mouse-intervertebral-disc
#40
JOURNAL ARTICLE
Jiawei Lu, Zuozhen Tian, Frances S Shofer, Ling Qin, Honghong Sun, Yejia Zhang
OBJECTIVE: TNFAIP8 and TIPE2 belong to TNFa-induced protein 8 (TNFAIP8/TIPE) family. They control apoptosis and direct leukocyte migration. Nucleus pulposus (NP) cell loss is a hallmark of intervertebral disc (IVD) degeneration in response to injury, and inflammation may cause pain. Here, we examined the effects of TNFAIP8/TIPE2 deficiency on the IVDs in mice with these genes deleted. DESIGN: Tail IVDs in Tnfaip8 or Tipe2 single and double knockout mice (Tnfaip8-/-, Tipe2-/-, and Tnfaip8/Tipe2 dko), and wild type (WT) controls were injured...
April 9, 2024: American Journal of Physical Medicine & Rehabilitation
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