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https://www.readbyqxmd.com/read/29457828/dihydrodiosgenin-protects-against-experimental-acute-pancreatitis-and-associated-lung-injury-through-mitochondrial-protection-and-pi3k%C3%AE-akt-inhibition
#1
Yan Shen, Li Wen, Rui Zhang, Zeliang Wei, Na Shi, Qiuyang Xiong, Qing Xia, Zhihua Xing, Zhi Zeng, Hai Niu, Wen Huang
BACKGROUND AND PURPOSE: Acute pancreatitis (AP) is a painful and burdensome exocrine pancreatic disorder with no specific drug treatment. Diosgenyl saponin extracts from Dioscorea zingiberensis C. H. Wright were reported to protect against experimental models of AP and diosgenin or its derivatives have anti-inflammatory effects in various diseases. However, the effects of diosgenin and its spiroacetal ring opened analog dihydrodiosgenin (Dydio) have not yet been determined in AP. EXPERIMENTAL APPROACH: Various concentrations of diosgenin and Dydio were tested for sodium taurocholate hydrate (Tauro)-induced necrosis in freshly isolated murine pancreatic acinar cells...
February 19, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29457147/a-scoping-review-of-health-outcomes-examined-in-randomized-controlled-trials-using-guided-imagery
#2
Peter R Giacobbi, Jonathan Stewart, Keeley Chaffee, Anna-Marie Jaeschke, Meagan Stabler, George A Kelley
Introduction: Guided imagery involves the controlled visualization of detailed mental images. This integrative health technique is used for healing, health maintenance, or the treatment of specific conditions. Guided imagery is an integral part of mindfulness meditation, hypnosis, and various relaxation exercises. However, evidence to support the widespread use and dissemination of guided imagery interventions has been lacking. The purposes of this scoping review were to document the scope of health outcomes and disease processes examined by guided imagery researchers and the journal outlets where this work has been published...
December 2017: Progress in Preventive Medicine
https://www.readbyqxmd.com/read/29455921/clinical-and-epidemiological-characteristics-of-intestinal-parasite-infection-by-blastocystis-hominis
#3
C Ocaña-Losada, J A Cuenca-Gómez, M T Cabezas-Fernández, J Vázquez-Villegas, M J Soriano-Pérez, I Cabeza-Barrera, J Salas-Coronas
OBJECTIVES: Blastocystis hominis (B. hominis) is one of the most common intestinal parasites isolated in humans. The parasite can cause gastrointestinal symptoms or, in most cases, remain asymptomatic. There are issues concerning the parasite's pathogenic character. The aim of this study was to analyse the clinical and epidemiological characteristics of the parasite infection by B. hominis, with or without other parasitic co-infections. PATIENTS AND METHODS: An observational retrospective study was conducted of B...
February 15, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29453927/effect-of-prenatal-recommendations-of-traditional-persian-medicine-on-obstetric-outcomes-a-randomized-clinical-trial
#4
Mansoor Keshavarz, Maryam Kashanian, Soodabeh Bioos, Yasaman Vazani
wufjhjdkf Background Traditional Persian Medicine (TPM) is an ancient medical system that provides suggestions to improve the health of mothers and children during pregnancy and labor. Persian physicians believed that these instructions made labor easier, safer, and less painful. Methods The present randomized clinical trial was conducted among women at 33-38 weeks of pregnancy in Tehran, Iran. TPM instructions consisted of diet, bathing, and application of oil from the 38th week of pregnancy to the onset of labor...
February 17, 2018: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29453701/eanm-guidelines-for-radionuclide-therapy-of-bone-metastases-with-beta-emitting-radionuclides
#5
Daria Handkiewicz-Junak, Thorsten D Poeppel, Lisa Bodei, Cumali Aktolun, Samer Ezziddin, Francesco Giammarile, Roberto C Delgado-Bolton, Michael Gabriel
The skeleton is the most common metastatic site in patients with advanced cancer. Pain is a major healthcare problem in patients with bone metastases. Bone-seeking radionuclides that selectively accumulate in the bone are used to treat cancer-induced bone pain and to prolong survival in selected groups of cancer patients. The goals of these guidelines are to assist nuclear medicine practitioners in: (a) evaluating patients who might be candidates for radionuclide treatment of bone metastases using beta-emitting radionuclides such as strontium-89 ( 89 Sr), samarium-153 ( 153 Sm) lexidronam ( 153 Sm-EDTMP), and phosphorus-32 ( 32 P) sodium phosphate; (b) performing the treatments; and...
February 16, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29452222/essential-medicines-availability-is-still-suboptimal-in-many-countries-a-scoping-review
#6
REVIEW
Mersiha Mahmić-Kaknjo, Antonia Jeličić-Kadić, Ana Utrobičić, Kit Chan, Lisa Bero, Ana Marušić
OBJECTIVE: To identify uses of WHO Model list of essential medicines (EM) and summarize studies examining essential medicines (EM) and national EM lists (NEMLs). STUDY DESIGN AND SETTING: In this scoping review, we searched PubMed, Scopus, WHO website and WHO Regional Databases for studies on NEMLs, reimbursement medicines lists, and WHO EML, with no date or language restrictions. RESULTS: 3,144 retrieved documents were independently screened by two reviewers; 100 full-text documents were analyzed; 37 contained data suitable for quantitative and qualitative analysis on EMs availability (11 documents), medicines for specific diseases (13 documents), and comparison of WHO EML and NEMLs (13 documents)...
February 13, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29449771/the-effectiveness-of-manual-physical-therapy-interventions-in-pediatric-patients-with-anterior-hip-pain-a-retrospective-study
#7
Mindy Galleher, Briana Crowe, Mitchell Selhorst
Objectives: The purposes of this study were to: (1) assess the benefit of adding manual therapy (MT) to physical therapy care in pediatric patients with anterior hip pain; (2) assess the relative risk of adverse reactions when MT is used; and (3) report the types of MT used. Methods: This study was a retrospective chart review of patients treated in a hospital-based sports medicine clinic. The charts of 201 patients (mean age = 14.23 ± 2.15 years) met the inclusion criteria and were reviewed...
December 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/29447711/no-355-physiologic-basis-of-pain-in-labour-and-delivery-an-evidence-based-approach-to-its-management
#8
Julie Bonapace, Guy-Paul Gagné, Nils Chaillet, Raymonde Gagnon, Emmanuelle Hébert, Sarah Buckley
OBJECTIVE: To review the evidence relating to nonpharmacological approaches in the management of pain during labour and delivery. To formulate recommendations for the usage of nonpharmacological approaches to pain management. OPTIONS: Nonpharmacological methods available for pain management during labour and delivery exist. These should be included in the counselling and care of women. EVIDENCE: PubMed and Medline were searched for articles in French and English on subjects related to "breastfeeding," "pain," "epidural," "anaesthesia," "analgesia," "labour," "labor," and combined with "gate control theory," "alternative therapies," "massage," "position," "mobility," "TENS," "bathing," "DNIC," "acupuncture," "acupressure," "sterile water injection," "higher center," "control mind," "cognitive structuring," "holistic health," "complementary therapy(ies)," "breathing," "relaxation," "mental imagery," "visualization," "mind focusing," "hypnosis," "auto-hypnosis," "sophrology," "mind and body interventions," "music," "odors," "biofeedback," "Lamaze," "Bonapace," "prenatal training," "gymnastic," "chanting," "haptonomy," "environment," "transcutaneous electrical stimulus-stimulation," "antenatal education," "support," "continuous support," "psychosocial support," "psychosomatic medicine," "supportive care," "companion," "intrapartum care," "nurse," "midwife(ves)," "father," "doula," "caregiver," " hormones," "oxytocin," "endorphin," "prolactin," "catecholamine," "adrenaline," and "noradrenaline" from 1990 to December 2015...
February 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29447382/randomized-controlled-trial-of-acupuncture-for-women-with-fibromyalgia-group-acupuncture-with-traditional-chinese-medicine-diagnosis-based-point-selection
#9
Scott D Mist, Kim Dupree Jones
Background: Group acupuncture is a growing and cost-effective method for delivering acupuncture in the United States and is the practice model in China. However, group acupuncture has not been tested in a research setting. Objective: To test the treatment effect of group acupuncture vs group education in persons with fibromyalgia. Design: Random allocation two-group study with repeated measures. Setting: Group clinic in an academic health center in Portland, Oregon...
February 13, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29447356/barriers-to-the-availability-and-accessibility-of-controlled-medicines-for-chronic-pain-in-africa
#10
Elmang Nchako, Scottie Bussell, Carlos Nesbeth, Chisom Odoh
Africans endure a high burden of pain and suffering from HIV/AIDS and cancer, yet receive a meager amount of the world's pain medication. This tragedy occurs needlessly, given that inexpensive, effective and easily administered interventions are available. WHO has a 'three-step analgesic ladder' framework for managing cancer pain. This widely adopted clinical practice guideline is an integral part of palliative care programs and has also been applied to non-cancer pain. However, untreated pain is a major public health problem due to the discordance between scientific evidence and public policy...
February 13, 2018: International Health
https://www.readbyqxmd.com/read/29447136/individualized-neuropathic-pain-therapy-based-on-phenotyping-are-we-there-yet
#11
Julia Forstenpointner, Jan Otto, Ralf Baron
Patients with the same neuropathic pain disorder may have completely different sensory signs and symptoms yet receive the same medicinal treatment. New concepts suggest that patient stratification according to their pain mechanisms, reflected in their sensory phenotype, could be promising to implement an individualized therapy in neuropathic pain. Retrospective classification of patients according to their sensory phenotype showed predictive validity and reliability for treatment response in certain subgroups of patients...
March 2018: Pain
https://www.readbyqxmd.com/read/29446873/laser-stimulating-st36-with-optical-fiber-induce-blood-component-changes-in-mice-a-raman-spectroscopy-study
#12
Heng Zhang, Zhenyi Chen, Jiping Wu, Na Chen, Wenjie Xu, Taihao Li, Shupeng Liu
ST36 is a commonly-used acupoint in traditional Chinese medicine (TCM) for treatment of inflammations, pains and gastrointestinal disturbs. For decades,the low power laser acupuncture has been widely applied as an alternative therapy to traditional metal needle acupuncture and achieved relatively fine therapeutic effect for ST36-related symptoms with reduction of uncomfortableness and infection risks. However its disadvantages of low penetrativity and lack of manipulation skills limit its potential performance...
February 15, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29446825/phytomedicines-medicines-derived-from-plants-for-sickle-cell-disease
#13
REVIEW
Oluseyi Oniyangi, Damian H Cohall
BACKGROUND: Sickle cell disease, a common recessively inherited haemoglobin disorder, affects people from sub-Saharan Africa, the Middle East, Mediterranean basin, Indian subcontinent, Caribbean and South America. It is associated with complications and a reduced life expectancy. Phytomedicines (medicine derived from plants in their original state) encompass many of the plant remedies from traditional healers which the populations most affected would encounter. Laboratory research and limited clinical trials have suggested positive effects of phytomedicines both in vivo and in vitro...
February 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29441591/beyond-the-binaries-reshaping-pain-communication-through-arts-workshops
#14
Jen Tarr, Flora Cornish, Elena Gonzalez-Polledo
Pain is difficult to communicate and translate into language, yet most social research on pain experience uses questionnaires and semi-structured interviews that rely on words. In addition to the mind/body dualism prevalent in pain medicine in these studies pain communication is characterised by further value-laden binaries such as real/unreal, visible/invisible, and psychological/physical. Starting from the position that research methods play a role in constituting their object, this article examines the potential of participatory arts workshops for developing different versions of pain communication...
February 13, 2018: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29440815/aspiring-pain-practitioners-in-india-assessing-challenges-and-building-opportunities
#15
Sushma Bhatnagar, Anuradha Patel, Srinivasa N Raja
Background: Pain medicine is a developing specialty, aimed at relieving pain and suffering, enhancing function, and improving the quality of life of patients. Pain is often ignored, under-reported and mismanaged by health-care providers. Aspiring pain physicians in India face many challenges and barriers in advancing their specialty. Objectives: The objective of this study is to determine the challenges in establishing a pain practice in India and to discuss the opportunities and strategies to overcome these barriers...
January 2018: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29440814/effectiveness-of-the-certificate-course-in-essentials-of-palliative-care-program-on-the-knowledge-in-palliative-care-among-the-participants-a-cross-sectional-interventional-study
#16
Sushma Bhatnagar, Anuradha Patel
Background: Palliative medicine is an upcoming new specialty aimed at relieving suffering, improving quality of life and comfort care. There are many challenges and barriers in providing palliative care to our patients. The major challenge is lack of knowledge, attitude and skills among health-care providers. Objectives: Evaluate the effectiveness of the certificate course in essentials of palliative care (CCEPC) program on the knowledge in palliative care among the participants...
January 2018: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29440806/prevalence-and-intensity-of-dyspnea-in-advanced-cancer-and-its-impact-on-quality-of-life
#17
Anuja Damani, Arunangshu Ghoshal, Naveen Salins, Jayita Deodhar, MaryAnn Muckaden
Context: Dyspnea is a subjective, multidimensional experience of breathing discomfort, commonly seen in patients with advanced cancer. To find the impact of dyspnea on the quality of life in this population, it is important to understand the prevalence and factors influencing dyspnea. Aims: This study aimed to determine the prevalence, intensity, and factors influencing dyspnea in advanced cancer and determine its impact on overall quality of life. Settings and Design: This was a prospective cross-sectional study...
January 2018: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29439805/-qualitative-and-quantitative-study-of-ophthalmologic-consultation-in-france-a-multicenter-descriptive-survey
#18
P Y Santiago, F Becquet, X Zanlonghi, J M Bosc
This study aimed to precisely map current ophthalmologic consultation in France through systematic data collection in one consultation day. Nine ophthalmologic centers participated in the survey, performing 1148 observations of patients aged from 2 to 102 years old, with a mean of 55.12years old and a male/female distribution of 43.8 %/56.2 %. In general, the patients came in either spontaneously (28.8 %) or for follow-up (59.6 %). Emergency consultations comprised 5.7 % of all cases. Comorbidities or major risk factors were found...
February 10, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29436758/perception-of-dental-students-on-risk-factors-of-musculoskeletal-disorders
#19
A C Botta, C D Presoto, D Wajngarten, J A D B Campos, P P N S Garcia
OBJECTIVE: To evaluate the validity and reliability of the Job Factors Questionnaire, and the influence of gender, academic level and pain/discomfort on dental students' perception regarding risk factors of musculoskeletal disorders. METHODS: One hundred forty-five dental students from Stony Brook School of Dental Medicine participated voluntarily in this study. The survey was organised in two sections: (i) Job Factors Questionnaire with 15 items that evaluated students' perceptions about job/study environmental risk factors and their potential contribution to musculoskeletal disorders...
February 13, 2018: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/29436106/corticosteroid-and-cortisol-serum-levels-following-intra-articular-triamcinolone-acetonide-lumbar-facet-joint-injections
#20
Rozalin R Dickson, Joel M Reid, Wayne T Nicholson, Tim J Lamer, W Michael Hooten
BACKGROUND: Facet joint steroid injections are used to treat chronic low back. However, little is known about the systemic absorption and serum levels of steroids following intra-articular facet joint injections. The primary objective of this preliminary study was to investigate the pharmacokinetics of triamcinolone acetonide following fluoroscopically guided intra-articular lumbar facet joint injections in a cohort of patients with chronic low back pain. A secondary aim was to investigate the effects of triamcinolone on serum cortisol levels following lumbar facet joint injections...
February 12, 2018: Pain Practice: the Official Journal of World Institute of Pain
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