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https://www.readbyqxmd.com/read/29923616/medicinal-cannabinoids-in-palliative-care
#1
REVIEW
M Agar
The treatment of symptoms in people with palliative diagnoses begins with meticulous clinical assessment with treatment choice (s) selected based on an understanding of the symptom aetiology and the evidence which underpins its treatment. Increasingly the merits of palliative care have been established earlier in the disease trajectory where treatment outcomes may include increased survival and maintenance of function. There is strong public support for the availability of medicinal cannabis, particularly for people with palliative diagnoses...
June 20, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29923612/the-construction-and-application-of-a-population-physiologically-based-pharmacokinetic-model-for-methadone-in-beagles-and-greyhounds
#2
Trevor Elwell-Cuddy, Miao Li, Butch KuKanich, Zhoumeng Lin
Methadone is an opioid analgesic in veterinary and human medicine. To help develop appropriate pain management practices and to develop a quantitative model for predicting methadone dosimetry, a flow-limited multiroute physiologically based pharmacokinetic (PBPK) model for methadone in dogs constructed with Berkeley Madonna™ was developed. The model accounts for intravenous (IV), subcutaneous (SC), and oral administrations, and compartmentalizes the body into different components. This model was calibrated from plasma pharmacokinetic data after IV administration of methadone in Beagles and Greyhounds...
June 20, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29923025/cannabinoids-for-treatment-of-ms-symptoms-state-of-the-evidence
#3
REVIEW
Jessica Rice, Michelle Cameron
PURPOSE OF REVIEW: Cannabis and cannabinoids have been used medically and recreationally for thousands of years and recently there has been a growing body of research in this area. With increased access now that medical marijuana is available in many jurisdictions, patients and providers want to know more about the evidence for benefits and risks of cannabinoid use. This paper provides an overview of the available cannabinoid-based formulations, a summary of the highest quality evidence for the use of cannabinoids for treating spasticity and pain associated with multiple sclerosis (MS), and a discussion of possible dosing regimens based on information from these studies...
June 19, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29922843/the-role-of-appearance-definition-of-appearance-pain-app-pain-and-systematic-review-of-patient-reported-outcome-measures-used-in-literature
#4
M Barone, A Cogliandro, R Salzillo, V Tambone, P Persichetti
INTRODUCTION: The objectives of the current study were: (1) to perform a systematic review of the existing scientific literature on appearance and any subsequently related disorders and (2) to research in the literature the correlation between the role of appearance and patient's disease. MATERIALS AND METHODS: A systematic review protocol was developed a priori in accordance with the Preferred Reporting for Items for Systematic Reviews and Meta-Analyses-Protocols (PRISMA-P) guidance...
June 19, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29922158/-syzygium-aqueum-a-polyphenol-rich-leaf-extract-exhibits-antioxidant-hepatoprotective-pain-killing-and-anti-inflammatory-activities-in-animal-models
#5
Mansour Sobeh, Mona F Mahmoud, Ganna Petruk, Samar Rezq, Mohamed L Ashour, Fadia S Youssef, Assem M El-Shazly, Daria M Monti, Ashraf B Abdel-Naim, Michael Wink
Syzygium aqueum is widely used in folk medicine. A polyphenol-rich extract from its leaves demonstrated a plethora of substantial pharmacological properties. The extract showed solid antioxidant properties in vitro and protected human keratinocytes (HaCaT cells) against UVA damage. The extract also reduced the elevated levels of ALT, AST, total bilirubin (TB), total cholesterol (TC) and triglycerides (TG) in rats with acute CCl4 intoxication. In addition to reducing the high MDA level, the extract noticeably restored GSH and SOD to the normal control levels in liver tissue homogenates and counteracted the deleterious histopathologic changes in liver after CCl4 injection...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29921169/-express-auricular-vagus-nerve-stimulation-enhances-central-serotonergic-function-and-inhibits-diabetic-neuropathy-development-in-zucker-fatty-rats
#6
Shayuan Li, Chunli Sun, Peijing Rong, Xu Zhai, Jinling Zhang, Max Baker, Shuxing Wang
Painful neuropathy is a frequent comorbidity in diabetes. Zucker diabetic fatty (ZDF, fa/fa) rats develop type 2 diabetes spontaneously with ageing and show nociceptive hypersensitivity by age of 13wk. In preclinical and clinical studies, the treatment of diabetic neuropathy is challenging but complementary medicine like transcutaneous auricular vagus nerve stimulation (taVNS) appears beneficial to the relief of neuropathic pain. However, the mechanism behind the effectiveness of taVNS remains unclear. In this study we show that daily 30min taVNS (2/15Hz, 2mA) for consecutive 27 days effectively inhibited the development of nociceptive hypersensitivity in ZDF rats as detected by thermal hyperalgesia and mechanical allodynia in hindpaw...
January 1, 2018: Molecular Pain
https://www.readbyqxmd.com/read/29917100/conventional-and-biologic-disease-modifying-anti-rheumatic-drugs-for-osteoarthritis-a-meta-analysis-of-randomized-controlled-trials
#7
Monica S M Persson, Aliya Sarmanova, Michael Doherty, Weiya Zhang
Objectives: The role of inflammation in OA is controversial and it is unclear whether suppressing inflammation with conventional or biologic DMARDs is effective. A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to compare DMARDs with placebo in participants with symptomatic OA. Methods: Databases (Medline, Embase, Allied and Complementary Medicine Database, Web of Science and Cochrane Library), conference abstracts and ClinicalTrials...
June 16, 2018: Rheumatology
https://www.readbyqxmd.com/read/29916575/-le-tibetan-singing-bowls-e-l-intervento-musicoterapeutico
#8
Chiara Imbriani
OBJECTIVES: The use of idiofonic ethnical istruments known as "Tibetan Singing Bowls", characterized by a fascinating sound and a deep vibration, have been for millennials part of a culture including music, rythuals, theory of Chakra and oriental Ayurvedical medicine. METHODS: The practice of utilization of the Bowls is related to Sound Therapy rather than to Music Therapy, since the therapeutic effects appears to be a consequence of the vibrations of the Bowls, and not from their music...
December 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29916050/opioid-analgesic-drugs-and-serotonin-toxicity-syndrome-mechanisms-animal-models-and-links-to-clinical-effects
#9
REVIEW
Brian A Baldo
Drugs may cause serotonin toxicity by a number of different mechanisms including inhibition of serotonin uptake and metabolism, increased serotonin synthesis and release, activation of serotonin receptors, and inhibition of cytochrome P450 oxidases. Some drug interactions involving opioids can increase intrasynaptic levels of serotonin, and opioid analgesic drugs are now recognized as being involved in some cases of serotonin toxicity especially if administered in conjunction with other serotonergic medications including monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and tricyclic antidepressants...
June 18, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29915906/effect-of-shexiang-tongxin-dropping-pills-on-the-immediate-blood-flow-of-patients-with-coronary-slow-flow
#10
Sheng-Huang Wang, Lin Chu, Zhao Xu, Hong-Lin Zhou, Jiang-Fei Chen, Huang-Fu Ning
OBJECTIVE: To observe the immediate effect and safety of Shexiang Tongxin dropping pills ( , STDP) on patients with coronary slow flow (CSF), and furthermore, to explore new evidence for the use of Chinese medicine in treating ischemic chest pain. METHODS: Coronary angiography (CAG) with corrected thrombolysis in myocardial infarction (TIMI) frame count (CTFC) was applied (collected at 30 frames/s). The treatment group included 22 CSF patients, while the control group included 22 individuals with normal coronary flow...
June 18, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29913923/national-guidelines-for-evaluating-pain-patients-legal-right-to-prioritised-health-care-at-multidisciplinary-pain-clinics-in-norway-implemented-2009
#11
Karen Walseth Hara, Petter Borchgrevink
Background All nations are posed with the challenge of deciding how to allocate limited health care resources. A Patients' Rights Law from 1999 gives patients in Norway with a serious health condition, for which there is efficacious and cost-effective treatment, a legal right to receive health care from the National Health Care system. Methods Recently national guidelines have been produced for implementing these legal rights within 32 fields of specialist health care. One of these fields deals with serious chronic pain conditions...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913751/parenteral-opioids-in-emergency-medicine-a-systematic-review-of-efficacy-and-safety
#12
Leila Niemi-Murola, Jani Unkuri, Katri Hamunen
Introduction and aim Pain is a frequent symptom in emergency patients and opioids are commonly used to treat it at emergency departments and at pre-hospital settings. The aim of this systematic review is to examine the efficacy and safety of parenteral opioids used for acute pain in emergency medicine. Method Qualitative review of randomized controlled trials (RCTs) on parenteral opioids for acute pain in adult emergency patients. Main outcome measures were: type and dose of the opioid, analgesic efficacy as compared to either placebo or another opioid and adverse effects...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913748/opioids-in-emergency-medicine-are-we-treating-pain-adequately
#13
Kristiina S Kuusniemi, Klaus T Olkkola
No abstract text is available yet for this article.
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913711/some-practical-treatment-methods-of-dealing-with-pain-disabilities-in-rural-ghana
#14
Desmond Ayim-Aboagye, T Gordh
Background and aims The investigation was conducted among six practitioners and twenty-two patients in rural Ghana, where both practitioners and patients, were asked to unveil effective methods of treating pain and pain disabilities. Methods The investigation utilised strictly observational methods in acquiring data from two communities. Both patients and practitioners were later interviewed in a manner that elicited certain information needed to provide accurate understanding concerning these treatments methods they give to patients...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913700/experiences-with-an-adaptive-design-for-a-dose-finding-study-in-osteoarthritis
#15
F Miller, M Björnsson, O Svensson, R Karlsten
Aims Many new potential medicines fail in early clinical development. AZD1386 is a TRPV1 antagonist and was developed for treatment of osteoarthritis pain at AstraZeneca. Following preclinical studies to characterize the compound, translational studies and first time in man studies the challenge is great to select the right doses and study population for the first clinical studies on efficacy in phase II of the drug development process. Methods Different design alternatives in the planning of the dose-finding study for AZD1386 in OA were analysed with regard to statistical considerations, timelines and costs for the different options...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913698/placebo-responses-in-patients-with-peripheral-neuropathic-pain
#16
Karen Lund, Dyveke T Demant, Lene Vase, Søren H Sindrup, Troels S Jensen, Nanna B Finnerup
Background and aim Treatment responses during placebo periods in randomized clinical trials (RCTs) are quite often substantial and may impede a positive outcome of the trial. It would therefore be beneficial to gain more knowledge on factors contributing to large placebo responses in RCTs. The aim of the current study was to identify predictors of placebo responses in patients with peripheral neuropathic pain. Hypotheses We hypothesized that a high baseline pain intensity and variability will be predictive of large responses during placebo treatment...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913682/gch1-variants-tetrahydrobiopterin-and-their-effects-on-pain-sensitivity
#17
REVIEW
Arafat Nasser, Lisbeth Birk Møller
Background A great proportion of the variation in pain experience and chronicity is caused by heritable factors. Within the last decades several candidate genes have been discovered either increasing or decreasing pain sensitivity or the risk of chronic pain in humans. One of the most studied genes is the GCH1 gene coding for the enzyme GTP cyclohydrolase 1 (GCH1). GCH1 catalyses the initial and rate-limiting step in the biosynthesis of tetrahydrobiopterin (BH4). The main function of BH4 is regulation of monoamine and nitric oxide biosynthesis, all involved in nociceptive signalling...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913645/a-pediatric-patients-pain-evaluation-in-the-emergency-unit
#18
Anette Lemström
AimsHelsinki University Hospital for Children and Adolescents treats 0-to 16-year old pediatric and surgical patients. The patients arrive to the emergency unit by ambulance, referral or by decision of the triage nurse. The most common reason for visit is pain. VAS pain scale should be used, but pain is not evaluated properly. The aim of this study was to review literature on evaluation and treatment of pain in pediatric emergency unit. MethodsA search from Cinahl and Finnish Medic-database covering last 10 years was performed using: pain, child, trauma, documentation, evaluation, emergency and assessment as keywords...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913640/the-most-important-step-forward-in-modern-medicine-a-giant-leap-for-mankind-insensibility-to-pain-during-surgery-and-painful-procedures
#19
Harald Breivik
No abstract text is available yet for this article.
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913623/in-praise-of-anesthesia-two-case-studies-of-pain-and-suffering-during-major-surgical-procedures-with-and-without-anesthesia-in-the-united-states-civil-war-1861-65
#20
Maurice S Albin
Background The United States Civil War (1861-1865) pitted the more populous industrialized North (Union) against the mainly agricultural slaveholding South (Confederacy). This conflict cost an enormous number of lives, with recent estimates mentioning a total mortality greater than 700,000 combatants [1]. Although sulfuric ether (ETH) and chloroform (CHL) were available since Morton's use of the former in 1846 and the employment of the latter in 1847, and even though inhalational agents were used in Crimean war (1853-1856) and the Mexican-American War (1846-1848), the United States Civil War gave military surgeons on both sides the opportunity to experience the use of these two agents because of the large number of casualties...
December 29, 2017: Scandinavian Journal of Pain
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