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https://www.readbyqxmd.com/read/29928755/prophylactic-abdominal-drainage-for-pancreatic-surgery
#1
REVIEW
Wei Zhang, Sirong He, Yao Cheng, Jie Xia, Mingliang Lai, Nansheng Cheng, Zuojin Liu
BACKGROUND: The use of surgical drains has been considered mandatory after pancreatic surgery. The role of prophylactic abdominal drainage to reduce postoperative complications after pancreatic surgery is controversial. OBJECTIVES: To assess the benefits and harms of routine abdominal drainage after pancreatic surgery, compare the effects of different types of surgical drains, and evaluate the optimal time for drain removal. SEARCH METHODS: For the last version of this review, we searched CENTRAL (2016, Issue 8), and MEDLINE, Embase, Science Citation Index Expanded, and Chinese Biomedical Literature Database (CBM) to 28 August 2016)...
June 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29927872/nutritional-considerations-in-pediatric-pancreatitis-a-position-paper-from-the-nasphan-pancreas-committee-and-esphan-cystic-fibrosis-pancreas-working-group
#2
Maisam Abu-El-Haija, Aliye Uc, Steven L Werlin, Alvin Jay Freeman, Miglena Georgieva, Danijela Jojkić-Pavkov, Daina Kalnins, Brigitte Kochavi, Bart G P Koot, Stephanie Van Biervliet, Jaroslaw Walkowiak, Michael Wilschanski, Veronique D Morinville
OBJECTIVES: Wide variations exist in how physicians manage the nutritional aspects of children affected by acute pancreatitis (AP), acute recurrent pancreatitis (ARP), and chronic (CP) pancreatitis. Better consensus for optimal management is needed. METHODS: This consensus statement on nutrition in pediatric pancreatic diseases was developed through a joint ESPGHAN-NASPGHAN working group that performed an evidence-based search of the literature on nutrition in AP, ARP, and CP with a focus on pediatrics...
July 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29924043/conservative-management-of-acute-calculous-cholecystitis-complicated-by-pancreatitis-in-an-elderly-woman-a-case-report
#3
Marta K Walczak-Galezewska, Damian Skrypnik, Monika Szulinska, Katarzyna Skrypnik, Pawel Bogdanski
RATIONALE: Acute calculous cholecystitis is a prevalent disease whose diagnosis and management still face significant debate. Although the overall incidence of gallstone disease is 18.8% in European women aged 30 to 69 years, there is little data and experience in managing acute calculous cholecystitis in populations over 80 years old. The incidence of acute cholecystitis among the elderly is probably increasing. For the reason, we here highlight the advantages and disadvantage of various treatment and management opens based on a 96-year-old patient...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923433/somatostatin-analogue-induced-pancreatic-exocrine-insufficiency-in-patients-with-neuroendocrine-tumours-results-of-a-prospective-observational-study
#4
Angela Lamarca, Lynne McCallum, Christina Nuttall, Jorge Barriuso, Alison Backen, Melissa Frizziero, Rebecca Leon, Was Mansoor, Mairéad G McNamara, Richard A Hubner, Juan W Valle
Background Patients with advanced well-differentiated neuroendocrine tumours(Wd-NETs) are commonly treated with somatostatin analogues(SSAs). Some patients may develop SSA-related side effects such as pancreatic exocrine insufficiency(PEI). Methods In this single-institution, prospective, observational study, the frequency of SSA-induced PEI in 50 sequential patients with advanced Wd-NETs treated with SSAs was investigated. Toxicity was assessed monthly and faecal elastase-1 (FE1) and quality of life (QoL) were assessed 3-monthly...
June 20, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29922897/is-there-an-effect-of-cannabis-consumption-on-acute-pancreatitis
#5
C Roberto Simons-Linares, Jodie A Barkin, Yuchen Wang, Palashkumar Jaiswal, William Trick, Michael J Bartel, Jamie S Barkin
BACKGROUND AND AIM: Twenty-percentage of acute pancreatitis (AP) cases is labeled as idiopathic. Cannabis remains the most frequently used illicit drug in the world. The aim of this study was to identify the prevalence of cannabis use among all patients with a first episode of AP, particularly in those labeled as idiopathic etiology, and determine any effect on AP severity. METHODS: Retrospective cohort of all consecutive patients admitted with a first episode of AP at a large tertiary referral hospital from 01/2013 through 12/2014...
June 20, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29921298/compound-but-non-linked-heterozygous-p-w14x-and-p-l279-v-lpl-gene-mutations-in-a-chinese-patient-with-long-term-severe-hypertriglyceridemia-and-recurrent-acute-pancreatitis
#6
Xiaoyao Li, Qi Yang, Xiaolei Shi, Weiwei Chen, Na Pu, Weiqin Li, Jieshou Li
BACKGROUND: Variants in the lipoprotein lipase (LPL), apolipoprotein C-II (APOC2), apolipoprotein A-V (APOA5), GPIHBP1 and LMF1 genes may cause severe hypertriglyceridemia (HTG), which is now the second-leading aetiology of acute pancreatitis in China. METHODS: The patient and his family were assessed for gene variants by Sanger sequencing of exons and exon-intron junctions of the LPL, GPIHBP1, APOA5, APOC2, and LMF1 genes. Post-heparin blood was collected for LPL mass and activity detection...
June 19, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29916850/sphincter-of-oddi-dysfunction-sphincter-of-oddi-dysfunction-or-discordance-what-is-the-state-of-the-art-in-2018
#7
Jong Jin Hyun, Richard A Kozarek
PURPOSE OF REVIEW: To review important manuscripts published over the previous 2 years relative to sphincter of Oddi dysfunction (SOD). RECENT FINDINGS: The long-term outcomes of the Evaluating Predictors and Interventions of SOD (EPISOD) trial further substantiated results from the initial EPISOD study, reinforcing that neither endoscopic retrograde cholangiopancreatography-manometry nor endoscopic sphincterotomy are appropriate for SOD type III. Pain management in the latter patients has reverted to neuromodulating agents, and recent studies have suggested a role for duloxetine and potentially acupuncture...
June 16, 2018: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/29915658/why-now-delayed-drug-induced-pancreatitis-due-to-dapsone-for-dermatitis-herpetiformis
#8
Youssef Yousry Soliman, Megan Sue Soliman, Farrukh Abbas
Drug-induced pancreatitis can be caused by a wide array of medications. In fact, the diagnosis is likely commonly missed due to the difficulty in diagnosing one agent as the sole cause. We present a case of dapsone-induced pancreatitis in a 75-year-old male with history of celiac disease. He presented with abdominal pain and was found to have acute pancreatitis. Interestingly, he had been on dapsone for 5 years and had no other recent medication changes, significant alcohol use, or gallbladder disease. It was determined this was an episode of delayed acute pancreatitis due to dapsone...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29911459/a-case-of-linezolid-induced-toxicity
#9
Philip E Tobias, Christy A Varughese, Amy P Hanson, Payal K Gurnani
Adverse effects of linezolid are typically limited to diarrhea, nausea, and headache when shorter durations are used; however, as extended durations of linezolid therapy are increasingly more common, additional monitoring parameters should be considered in these patients. We describe a unique case of hypoglycemia, lactic acidosis, and pancreatitis related to an extended duration of linezolid therapy. A 52-year-old woman presented with altered mental status, abdominal pain, and hypotension following six weeks of linezolid and ertapenem therapy...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29909684/hydatid-cyst-of-the-pancreas-causing-both-acute-pancreatitis-and-splenic-vein-thrombosis
#10
O Ozsay, F Gungor, Serkan Karaisli, Ibrahim Kokulu, Osman Nuri Dilek
Hydatid cyst of the pancreas is a rarely seen entity even in endemic countries. Cyst may causes several symptoms due to external compression or fistulisation to pancreaticobiliary tract or small bowel. A 23-year-old female patient was referred with a complaint of abdominal pain. Preoperative imaging revealed an undefined cyst in the tail of pancreas. She underwent distal pancreatectomy and splenectomy, with a diagnosis of acute pancreatitis due to cystopancreatic duct fistula and also left-sided portal hypertension due to splenic vein thrombosis...
June 18, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29904461/pancreatic-arteriovenous-malformation-mimicking-pancreatic-neoplasm-a-systematic-multimodality-diagnostic-approach-and-treatment
#11
Olga Nikolaidou, Ekaterini Xinou, Pavlos Papakotoulas, Andis Philippides, Dimitra Panagiotopoulou-Boukla
Pancreatic arteriovenous malformation (pAVM) is a very rare entity, as less than 100 cases are reported in the international literature. Patients with pAVM may be asymptomatic or may present a wide range of symptoms, such as vague pain, feeling of fullness, gastrointestinal bleeding, or even portal hypertension. We present the multimodality approach in the diagnosis of a patient with pAVM and treatment via transcatheter arterial embolization of the lesion using steel coils. The patient was free of symptoms 12 months later...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29904299/cholesterolosis-as-a-cause-of-acute-pancreatitis
#12
Ricardo E De Armas, Jacob M Rosenberg, Andrew Z Fenves
Acute pancreatitis is an inflammatory condition of the pancreas manifesting with abdominal pain and elevated serum levels of pancreatic enzymes. Gallstones and chronic alcohol use are the most commonly described causes. A less studied cause is cholesterolosis, gallbladder polyps that cause mechanical obstruction of the sphincter of Oddi. Here, we present the case of a 55-year-old woman who presented with acute pancreatitis and was found to have cholesterol polyps in her gallbladder with no evidence of gallstones...
July 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29901517/surgical-treatment-of-pain-in-chronic-pancreatitis
#13
Mariya E Skube, Greg J Beilman
PURPOSE OF REVIEW: Patients suffering from chronic pancreatitis often require surgical intervention to treat their disease. This review discusses surgical options as well as reviews current trends and research in the operative management of chronic pancreatitis. RECENT FINDINGS: Relevant current topics in the field include the appropriate timing of surgery as well as the relative benefits of various procedures, particularly duodenum-preserving pancreatic head resection versus pancreaticoduodenectomy...
June 8, 2018: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/29901515/total-pancreatectomy-and-islet-autotransplantion-for-chronic-and-recurrent-acute-pancreatitis
#14
Kendall R McEachron, Melena D Bellin
PURPOSE OF REVIEW: We reviewed the current state of total pancreatectomy with islet autotransplantation (TPIAT) for chronic pancreatitis and recurrent acute pancreatitis (RAP). RECENT FINDINGS: An increasing number of centers in the United States and internationally are performing TPIAT. In selected cases, TPIAT may be performed partially or entirely laparoscopically. Islet isolation is usually performed at the same center as the total pancreatectomy surgery, but new data suggest that diabetes outcomes may be nearly as good when a remote center is used for islet isolation...
June 8, 2018: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/29895203/pregnancy-after-whipple-procedure-a-new-case-and-review-of-the-literature
#15
Giulia Magoga, Laura Felder, Francesco Palazzo, Vincenzo Berghella
BACKGROUND: Whipple procedure is a complex operation usually performed to treat periampullary neoplasms. There are only four case reports of five pregnancies after Whipple procedure, with limited evidence about how to manage pregnancy after this surgery. CASE: A 28-year-old gravida 5 Para 2022 presented to our hospital at 20 weeks with worsening depression. She had a history of Whipple for a solid pseudopapillary neoplasm of the pancreas followed by two pregnancies...
June 12, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29894558/interventions-for-preventing-distal-intestinal-obstruction-syndrome-dios-in-cystic-fibrosis
#16
REVIEW
Jessica Green, Francis J Gilchrist, Will Carroll
BACKGROUND: Cystic fibrosis (CF) is the most common, life-limiting, genetically inherited disease. It affects multiple organs, particularly the respiratory system. However, gastrointestinal problems such as constipation and distal intestinal obstruction syndrome (DIOS) are also important and well-recognised complications in CF. They share similar symptoms e.g. bloating, abdominal pain, but are distinct conditions. Constipation occurs when there is gradual faecal impaction of the colon, but DIOS occurs when there is an accumulation of faeces and sticky mucus, forming a mass in the distal part of the small intestine...
June 12, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29892338/lower-gastrointestinal-symptoms-are-associated-with-worse-glycemic-control-and-quality-of-life-in-type-1-diabetes-mellitus
#17
John S Leeds, Marios Hadjivassiliou, Solomon Tesfaye, David S Sanders
Objectives: Lower gastrointestinal symptoms are not well characterized in people with type 1 diabetes, and the effects on quality of life and glycemic control are unknown. This study aimed to determine the prevalence of lower gastrointestinal symptoms and the effects on glycemic control and quality of life, and to investigate for underlying causes. Research design and methods: This is a prospective, cohort study in secondary care. Patients with type 1 diabetes completed a gastrointestinal symptom questionnaire and the Short Form 36 V...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29889589/the-effect-of-volanesorsen-treatment-on-the-burden-associated-with-familial-chylomicronemia-syndrome-the-results-of-the-refocus-study
#18
Marcello Arca, Andrew Hsieh, Handrean Soran, Paul Rosenblit, Louis O'Dea, Michael Stevenson
BACKGROUND: Volanesorsen, an investigational inhibitor of apoC-III synthesis, significantly reduced triglyceride levels in clinical trials in patients with familial chylomicronemia syndrome (FCS), a rare genetic disorder characterized by marked chylomicronemia leading to a spectrum of symptoms, including recurrent abdominal pain and episodes of potentially fatal acute pancreatitis (AP). OBJECTIVE: To determine the effect of volanesorsen on burden of disease on patients with FCS Methods: ReFOCUS was a retrospective global web-based survey open to patients with FCS who received volanesorsen for ≥3 months in an open-label extension study...
June 11, 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29885522/cannabinoid-receptor-type-1-in-the-brain-regulates-the-affective-component-of-visceral-pain-in-mice
#19
Danica Bajic, Krisztina Monory, Andrea Conrad, Christina Maul, Roland M Schmid, Carsten T Wotjak, Christoph K Stein-Thoeringer
Endocannabinoids acting through cannabinoid receptor type 1 (CB1) are major modulators of peripheral somatic and visceral nociception. Although only partially studied, some evidence suggests a particular role of CB1 within the brain in nociceptive processes. As the endocannabinoid system regulates affect and emotional behaviors, we hypothesized that cerebral CB1 influences affective processing of visceral pain-related behaviors in laboratory animals. To study nocifensive responses modulated by supraspinal CB1, we used conditional knock-out mice lacking CB1 either in cortical glutamatergic neurons (Glu-CB1-KO), or in forebrain GABAergic neurons (GABA-CB1-KO), or in principle neurons of the forebrain (CaMK-CB1-KO)...
June 6, 2018: Neuroscience
https://www.readbyqxmd.com/read/29883461/the-different-course-of-alcoholic-and-idiopathic-chronic-pancreatitis-a-long-term-study-of-2-037-patients
#20
Lu Hao, Li-Sheng Wang, Yu Liu, Teng Wang, Hong-Lei Guo, Jun Pan, Dan Wang, Ya-Wei Bi, Jun-Tao Ji, Lei Xin, Ting-Ting Du, Jin-Huan Lin, Di Zhang, Xiang-Peng Zeng, Wen-Bin Zou, Hui Chen, Ting Xie, Bai-Rong Li, Zhuan Liao, Zhi-Jie Cong, Zheng-Lei Xu, Zhao-Shen Li, Liang-Hao Hu
BACKGROUND: Chronic pancreatitis (CP) is a chronic inflammatory disease of the pancreas. This study aimed to compare the natural course of alcoholic chronic pancreatitis (ACP) and idiopathic chronic pancreatitis (ICP). METHODS: CP patients admitted to our center from January 2000 to December 2013 were enrolled. Characteristics were compared between ACP and ICP patients. Cumulative rates of diabetes mellitus (DM), steatorrhea, pancreatic stone, pancreatic pseudocyst, biliary stricture, and pancreatic cancer after the onset and the diagnosis of CP were calculated, respectively...
2018: PloS One
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