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https://www.readbyqxmd.com/read/29474970/increased-incidence-of-pseudoaneurysm-bleeding-with-lumen-apposing-metal-stents-compared-to-double-pigtail-plastic-stents-in-patients-with-peripancreatic-fluid-collections
#1
Bryan Brimhall, Samuel Han, Philip D Tatman, Toshimasa J Clark, Sachin Wani, Brian Brauer, Steven Edmundowicz, Mihir S Wagh, Augustin Attwell, Hazem Hammad, Raj J Shah
BACKGROUND & AIMS: There have been few studies that compared the effects of lumen-apposing metal stents (LAMS) and double pigtail plastic stents (DPS) in patients with peri-pancreatic fluid collections from pancreatitis. We aimed to compare technical and clinical success and adverse events in patients who received LAMS vs DPS for pancreatic pseudocysts and walled-off necrosis. METHODS: We performed a retrospective study of endoscopic ultrasound-mediated drainage in 149 patients (65% male; mean age, 47 years) with pancreatic pseudocysts or walled-off necrosis (97 received LAMS and 152 received DPS), from January 2011 through September 2016 at a single center...
February 20, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29474746/a-systematic-review-of-the-evidence-and-analysis-of-the-consequences
#2
REVIEW
J-Matthias Löhr, Nikola Panic, Miroslav Vujasinovic, Caroline S Verbeke
Senior people constitute the fastest growing segment of the population. The elderly are at risk for malnutrition, thought to be caused by reduced food intake or involution of the physiological capacity of the GI tract. Age-related changes are well known in other secretory organs such as liver, kidney, and intestine. The pancreas, representing a metabolically active organ with uptake and breakdown of essential nutritional components, changes its morphology and function with age. During childhood, the volume of the pancreas increases, reaching a plateau between 20-60 years, and declines thereafter...
February 23, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29473354/-clinical-observation-on-severe-acute-pancreatitis-treated-with-electroacupuncture-at-dachangshu-bl-25-and-shangjuxu-st-37-combined-with-ulinastatin
#3
Li Zhao, Xueqing Li, Zhimin Shi
OBJECTIVE: To observe the clinical therapeutic effects on severe acute pancreatitis (SAP) treated with electroacupuncture (EA), sparse-dense wave and 2 Hz/15 Hz, at Dachangshu (BL 25) and Shangjuxu (ST 37) assisting ulinastetin and explore the effective therapeutic method for SAP. METHODS: A total of 120 patients of SAP were randomized into an observation group and a control group, 60 cases in each one. In the control group, the routine western medicine was adopted with the intravenous drip with ulinastatin...
February 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29471608/-pancreatic-neuroendocrine-tumor-presenting-as-acute-pancreatitis
#4
Minjeong Kim, Jin Myung Park, Sung Joon Lee, Chang Don Kang, MyungHo Kang, Ji Hyun Kim, Seungkoo Lee, Seong Whi Cho
We report a case of acute pancreatitis secondary to pancreatic neuroendocrine tumor. A 46-year old man presented with upper abdominal pain. The serum amylase and lipase were elevated. Abdominal computed tomography (CT) and magnetic resonance cholangiopancreatography revealed a 1.7 cm sized mass at the pancreas body with a dilatation of the upstream pancreatic duct and mild infiltrations of peripancreatic fat. An endoscopic ultrasound-guided fine needle biopsy was performed for the pancreatic mass, but only necrotic tissue was observed on the pathologic examination...
February 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29465558/analysis-of-clinical-characteristics-and-treatment-of-immunoglobulin-g4-associated-cholangitis-a-retrospective-cohort-study-of-39-iac-patients
#5
Jianchun Xiao, Peiran Xu, Binglu Li, Tao Hong, Wei Liu, Xiaodong He, Chaoji Zheng, Yupei Zhao
Immunoglobulin (Ig)G4-associated cholangitis (IAC) is one of the common organ manifestations of IgG4-related systemic disease (ISD). IAC and autoimmune pancreatitis (AIP) may mimic sclerosing cholangitis, cholangiocarcinoma, or pancreatic carcinoma. Diagnosis is based on a combination of clinical, biochemical, radiological, and histological findings.To study the clinical presentation of and treatment strategy for IAC, we reviewed clinical, serologic, and imaging characteristics, as well as treatment response, in 39 patients with IAC...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29464657/acute-obstructive-suppurative-pancreatic-ductitis-aospd-in-pancreatic-cancer-treated-by-nasopancreatic-drainage
#6
Ryoko Shimizuguchi, Masataka Kikuyama, Terumi Kamisawa, Sawako Kuruma, Kazuro Chiba
An 80-year-old woman with pancreatic cancer was admitted with fever and abdominal pain. Blood examinations showed an elevated CRP level. On computed tomography (CT), a pancreatic tumor with a dilated upstream main pancreatic duct (MPD) was seen. Endoscopic retrograde cholangiopancreatography (ERCP) showed the strictured part of the MPD at the head of the pancreas with upstream dilatation. A nasopancreatic drainage tube was placed. Through the tube, purulent pancreatic juice was discharged and culture of the pancreatic juice grew Klebsiella pneumoniae...
February 20, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29462851/alleviating-pancreatic-cancer-associated-pain-using-endoscopic-ultrasound-guided-neurolysis
#7
REVIEW
Kosuke Minaga, Mamoru Takenaka, Ken Kamata, Tomoe Yoshikawa, Atsushi Nakai, Shunsuke Omoto, Takeshi Miyata, Kentaro Yamao, Hajime Imai, Hiroki Sakamoto, Masayuki Kitano, Masatoshi Kudo
The most common symptom in patients with advanced pancreatic cancer is abdominal pain. This has traditionally been treated with nonsteroidal anti-inflammatory drugs and opioid analgesics. However, these treatments result in inadequate pain control or drug-related adverse effects in some patients. An alternative pain-relief modality is celiac plexus neurolysis, in which the celiac plexus is chemically ablated. This procedure was performed percutaneously or intraoperatively until 1996, when endoscopic ultrasound (EUS)-guided celiac plexus neurolysis was first described...
February 15, 2018: Cancers
https://www.readbyqxmd.com/read/29462213/early-detection-of-pancreatic-cancer-in-mouse-models-using-a-novel-antibody-tab004
#8
Shu-Ta Wu, Chandra D Williams, Priyanka A Grover, Laura J Moore, Pinku Mukherjee
Pancreatic ductal adenocarcinoma (PDA) is the fourth-leading cause of cancer death in the United States with a 5-year overall survival rate of 8% for all stages combined. But this decreases to 3% for the majority of patients that present with stage IV PDA at time of diagnosis. The lack of distinct early symptoms for PDA is one of the primary reasons for the late diagnosis. Common symptoms like weight loss, abdominal and back pains, and jaundice are often mistaken for symptoms of other issues and do not appear until the cancer has progressed to a late stage...
2018: PloS One
https://www.readbyqxmd.com/read/29462081/the-opioid-epidemic-in-acute-care-surgery-characteristics-of-overprescribing-following-laparoscopic-cholecystectomy
#9
Kristine T Hanson, Cornelius A Thiels, Stephanie F Polites, Halena M Gazelka, Mohamed D Ray-Zack, Martin D Zielinski, Elizabeth B Habermann
BACKGROUND: Postoperative prescribing following acute care surgery must be optimized to limit excess opioids in circulation as misuse and diversion are frequently preceded by a prescription for acute pain. This study aimed to identify patient characteristics associated with higher opioid prescribing following laparoscopic cholecystectomy (LC). METHODS: Among patients age ≥18 years who underwent LC at a single institution 2014-2016, opioids prescribed at discharge were converted to oral morphine equivalents (OME) and compared to developing state guidelines (max 200 OME)...
February 17, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29460878/-laparoscopic-pancreatic-head-resection
#10
R E Izrailov, V V Tsvirkun, R B Alikhanov, A V Andrianov
AIM: To analyze the features and efficacy of laparoscopic Frey procedure. MATERIAL AND METHODS: For the period from August 2012 to May 2017 Frey procedure was carried out in 31 patients with chronic calculous pancreatitis Buchler type C. There were 20 men and 11 women aged 48.6±9 years. Mean pancreatic head dimension was 35.5±14 mm, diameter of the main pancreatic duct - 9.6±2.7 mm. RESULTS: Completely laparoscopic procedure was made in 28 (90...
2018: Khirurgiia
https://www.readbyqxmd.com/read/29459809/primary-adenosquamous-cell-carcinoma-of-the-pancreas-the-use-of-endoscopic-ultrasound-guided-fine-needle-aspiration-to-establish-a-definitive-cytologic-diagnosis
#11
Diogo Turiani Hourneaux De Moura, Martin Coronel, Danielle Azevedo Chacon, Ryan Tanigawa, Dalton M Chaves, Sérgio E Matuguma, Marcos E Lera Dos Santos, José Jukemura, Eduardo Guimarâes Hourneaux De Moura
Pancreatic cancer is the second most common malignancy of the gastrointestinal tract in the US, and adenocarcinoma has been identified as the most common type of pancreatic cancer. Different types of pancreatic cancers have been classified: adenocarcinoma, ductal adenosquamous carcinoma, solid pseudopapillary tumors, endocrine neoplasms, acinar cell carcinoma, squamous cell carcinoma, cystic tumors, primary lymphoma of the pancreas, and metastatic lesions of the pancreas. Adenosquamous carcinoma is extremely rare, behave in a very aggressive way and is responsible for the 1 to 4% of the pancreatic exocrine neoplastic lesions...
October 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29459566/-successful-endoscopic-ultrasound-guided-cyst-drainage-eus-cd-of-pancreatic-pseudocyst-in-the-abdominal-cavity-to-the-cervical-region-accompanied-by-spontaneous-rupture-into-the-portal-vein-a-case-study
#12
Takuya Takayanagi, Yusuke Sekino, Ken Ishii, Shinji Sato, Ryusuke Umemura, Shiori Uchiyama, Noriyoshi Kanazawa, Kenichi Kawana, Hajime Nagase
A 53-year-old man was admitted to our hospital with the complaint of neck pain and dyspnea. His blood examination revealed increased C-reactive protein and amylase levels. Enhanced computed tomography (CT) images demonstrated a retropharyngeal and a mediastinal low-density area extending to the portal area. He was diagnosed with pancreatic pseudocyst from the abdominal cavity to the cervical region accompanied by spontaneous rupture into the portal vein. Endoscopic ultrasound-guided cyst drainage (EUS-CD) of the most inferior cavity around the superior mesenteric artery was performed through the gastric wall...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29457828/dihydrodiosgenin-protects-against-experimental-acute-pancreatitis-and-associated-lung-injury-through-mitochondrial-protection-and-pi3k%C3%AE-akt-inhibition
#13
Yan Shen, Li Wen, Rui Zhang, Zeliang Wei, Na Shi, Qiuyang Xiong, Qing Xia, Zhihua Xing, Zhi Zeng, Hai Niu, Wen Huang
BACKGROUND AND PURPOSE: Acute pancreatitis (AP) is a painful and burdensome exocrine pancreatic disorder with no specific drug treatment. Diosgenyl saponin extracts from Dioscorea zingiberensis C. H. Wright were reported to protect against experimental models of AP and diosgenin or its derivatives have anti-inflammatory effects in various diseases. However, the effects of diosgenin and its spiroacetal ring opened analog dihydrodiosgenin (Dydio) have not yet been determined in AP. EXPERIMENTAL APPROACH: Various concentrations of diosgenin and Dydio were tested for sodium taurocholate hydrate (Tauro)-induced necrosis in freshly isolated murine pancreatic acinar cells...
February 19, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29456124/a-multicenter-study-of-total-pancreatectomy-with-islet-autotransplantation-tpiat-post-prospective-observational-study-of-tpiat
#14
Melena D Bellin, Maisam Abu-El-Haija, Katherine Morgan, David Adams, Gregory J Beilman, Srinath Chinnakotla, Darwin L Conwell, Ty B Dunn, Martin L Freeman, Timothy Gardner, Varvara A Kirchner, Luis F Lara, Leslie Long-Simpson, Jaimie D Nathan, Bashoo Naziruddin, John A Nyman, Timothy L Pruett, Sarah J Schwarzenberg, Vikesh K Singh, Kerrington Smith, Jennifer L Steel, Martin Wijkstrom, Piotr Witkowski, James S Hodges
BACKGROUND/OBJECTIVES: Total pancreatectomy with islet autotransplantation (TPIAT) is considered for managing chronic pancreatitis in selected patients when medical and endoscopic interventions have not provided adequate relief from debilitating pain. Although more centers are performing TPIAT, we lack large, multi-center studies to guide decisions about selecting candidates for and timing of TPIAT. METHODS: Multiple centers across the United States (9 to date) performing TPIAT are prospectively enrolling patients undergoing TPIAT for chronic pancreatitis into the Prospective Observational Study of TPIAT (POST), a NIDDK funded study with a goal of accruing 450 TPIAT recipients...
February 6, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29453786/long-term-outcomes-of-6-mm-diameter-of-fully-covered-self-expandable-metal-stents-in-benign-refractory-pancreatic-ductal-stricture
#15
Dongwook Oh, Jae Hoon Lee, Tae Jun Song, Do Hyun Park, Sung Koo Lee, Myung-Hwan Kim, Sang Soo Lee
OBJECTIVES: Fully covered self-expandable metal stents (FCSEMSs) placement has been tried for pancreatic ductal strictures in chronic pancreatitis. However, the long-term outcome of this procedure remains unknown. This study aimed to investigate the procedural and long-term outcomes of FCSEMS placement in patients with benign refractory pancreatic ductal strictures. METHODS: Between August 2011 and September 2015, 18 patients underwent endoscopic treatment with FCSEMSs for a benign refractory pancreatic ductal stricture...
February 17, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29444795/agenesis-of-dorsal-pancreas-in-a-young-adult-a-rare-cause-of-diabetes-mellitus
#16
Satyendra Kumar Sonkar, Satish Kumar, Neeraj Kumar Singh
Dorsal pancreatic agenesis is an extremely rare entity characterised by absence of body and tail of pancreas, while there are so many other developmental anomalies of the pancreas that have been reported. Here we report a 25-year-old young man who presented with pain in the abdomen, recurrent loose stools and hyperglycaemia. On radiological imaging study, there was complete agenesis of the dorsal pancreas except for thin stripe of tissue at the level of the uncinate process. Both exocrinedysfunction and endocrine dysfunction were present in this patient...
February 14, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29440961/acute-pancreatitis-during-glp-1-receptor-agonist-treatment-a-case-report
#17
Bogdan Augustin Chis, Daniela Fodor
Glucagon-like peptide 1 receptor agonists (GLP-1RA) are the newest treatment for diabetes mellitus (DM). These drugs can down-regulate fasting glucose more than oral drugs and lead to more constant glucose levels compared to regular insulin. Acute pancreatitis is a serious condition that may have a fatal outcome. It has been shown that long term and high doses of GLP-1RA can cause pancreatic changes in animals, but no connection has been proven in humans. We present the case of a 67 years old man with DM treated with oral drugs for 10 years until 3 months before, when GLP-1RA was added...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29439298/a-rare-cause-of-pancreatic-head-mass-metastatic-prostate-cancer-a-case-report-and-review-of-literature
#18
Khalil Aloreidi, Robert T Lapp
Metastases to the pancreas account for less than 5 percent of all malignancies affecting the pancreas. The most common secondary malignancy of the pancreas is renal cell carcinoma. We report a patient presented with abdominal pain and weight loss. Computed tomography (CT) imaging showed pancreatic head mass. Biopsy from the mass showed prostate metastasis after 13 years from radical prostatectomy and Leuprolide therapy. This case demonstrates a rare location for prostate metastasis which was the pancreas. To our knowledge there are only six cases reported in literature...
January 2018: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/29434948/granulocyte-colony-stimulating-factor-producing-mucinous-cystic-neoplasm-with-an-associated-invasive-carcinoma-of-the-pancreas
#19
Kazuhide Shimamatsu, Yoshiki Naito, Yutaro Mihara, Masamichi Nakayama, Masahiko Tanigawa, Yushi Abe, Ken Nakamura, Toshihiro Araki, Kenji Sakata, Kazunori Noguchi, Jun Akiba, Hirohisa Yano, Osamu Nakashima
The present case study documents an autopsy case of granulocyte-colony stimulating factor (G-CSF)-producing mucinous cystic neoplasm (MCN), with an associated invasive carcinoma of the pancreas. A 65-year-old woman presented to Omuta City Hospital (Omuta Japan) with a primary complaint of abdominal pain. Multiple liver nodules and a pancreatic cyst were detected upon abdominal computed tomography. Initially, liver abscess was suspected as the patient exhibited leukocytosis and elevated C-reactive protein level...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434732/sustained-multiple-organ-ischaemia-after-transarterial-chemoembolization-with-drug-eluting-beads-for-hepatocellular-carcinoma
#20
Young Woon Kim, Jung Hyun Kwon, Soon Woo Nam, Jeong Won Jang, Hyun Suk Jung, Yu Ri Shin, Eun Su Park, Dong Jae Shim
Transarterial chemoembolization (TACE) with drug-eluting beads (DC beads) may enhance drug delivery to tumours and reduce systemic toxicity. TACE with DC beads leads to significantly fewer serious side-effects compared with conventional TACE. A 66-year-old man with hepatocellular carcinoma (HCC) complained of continuous abdominal pain 1 month after TACE with DC beads. At the time of TACE, angiography revealed severe stenosis of both hepatic arteries. The diagnostic work up on admission suggested severe bile duct injury with regional bile duct dilatation, segmental liver and spleen infarction, necrotizing pancreatitis, as well as gastric and duodenal ulcers...
February 2018: Experimental and Therapeutic Medicine
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