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Katherine M Evely, Kerri D Pryce, Arin Bhattacharjee
Sodium-activated potassium (KNa) channels contribute to firing frequency adaptation and slow after hyperpolarization. The KCNT1 gene (also known as SLACK) encodes a KNa subunit that is expressed throughout the central and peripheral nervous systems. Missense mutations of the SLACK C-terminus have been reported in several patients with rare forms of early onset epilepsy and in some cases severely delayed myelination. To date, such mutations identified in patients with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), epilepsy of infancy with migrating focal seizures (EIMFS) and Ohtahara syndrome (OS) have been reported to be gain-of-function mutations (Villa and Combi, 2016)...
May 20, 2017: Neuroscience
S Matsuda, M Omoto, T Imai, K Seki, R Nomura, Y Otahara, T Yoshida, S Shima, H Kurita, K Nagaoka, H Taniwaki, Y Asada, K P Shai, M Koike, K Morita, Y Watanabe, H Mizoguchi, K Masamura, T Nagaya, R Inaba, H Sugiura, H Iwata, T Tanaka, G Ohi, I Uemura, A Akabayashi, I Kai, M Miyasaka, K Naka
No abstract text is available yet for this article.
April 1998: Environmental Health and Preventive Medicine
M Omoto, T Imai, K Seki, R Nomura, Y Otahara
Based on the fact that chemical products such as binding agents are produced by mixing three kinds of phosphates with different ratios, we mixed metaphosphate, polyphosphate and pyrophosphate. Each was made to Na-phosphate, K-phosphate, and Ca-phosphate and each was mixed with commercial feeds so that the content of P would be approximately 0.1, 0.15, 0.3, 0.4, 0.6 and 1.0%. The prepared pellets were given to ICR, CF # 1 and AKR strains of mice at 29 days of age for 680 days and observations were made through this experimental period at different stages...
October 1997: Environmental Health and Preventive Medicine
M Sugita, T Izuno, M Tatemichi, Y Otahara
Consumed substances, including food, drink, and tobacco, produced in the environment are exposure sources of Cd. The object of the present study was to estimate Cd exposure and absorption amount from smoking cigarettes, one exposure source of Cd, using recent findings from Japan. The market share of cigarettes produced in foreign countries has increased in Japan, the proportion of tobacco leaves harvested in foreign countries has increased in cigarettes produced in Japan, and the percentage of smokers in Japan has changed...
October 2001: Environmental Health and Preventive Medicine
Hayato Shimizu, Naoki Shimada, Yumi Otahara, Hisako Minowa, Yoji Hattori, Minoru Sugita
Improvement of an unhealthy lifestyle decreases the risk of incidence and mortality from lifestyle-related disease. One method for the improvement of an unhealthy lifestyle is interviewing for health and consultation regarding a healthy lifestyle to recipients of health checkups by public health nurses. Original articles in occupational health for recipients' evaluation in health checkups as longitudinal studies are rare. The purpose of the present study was to investigate in a longitudinal study the relationship between recipients' evaluation of interviews by public health nurses in a health checkup and variations in health checkup results for one year...
June 2008: Keio Journal of Medicine
S J You, D E Jung, H D Kim, H S Lee, H-C Kang
PURPOSE: To evaluate the efficacy and safety of adjunctive prednisolone therapy in children with cryptogenic epileptic encephalopathy, other than infantile spasms, and to determine its prognosis. METHODS: Prednisolone, 2mg/kg per day for 6 weeks, tapered for a further 2 weeks, was given in combination with previously prescribed antiepileptic drugs. A retrospective assessment of 41 children thus treated included measurements of seizure frequency, electroencephalographic findings, global assessments of cognitive function, and adverse drug events...
July 2008: European Journal of Paediatric Neurology: EJPN
Naoki Shimada, Michiko Miyakawa, Masayuki Tatemichi, Yumi Otahara, Takashi Izuno, Minoru Sugita
Numerous epidemiologic studies have revealed that smoking is a significant risk factor of many diseases. Some studies reported increase in medical expenditure by smoking using odds or hazard ratios between smoking and diseases in epidemiologic studies. The purpose of the present study is to investigate the ratios of mean medical expenditures between smokers and nonsmokers from studies conducted observing medical expenditure directly in Japan. We collected 11 published articles of studies conducted observing medical expenditures of smokers and nonsmokers directly in Japan...
June 2007: Keio Journal of Medicine
Kozo Kumagai, Hiroshi Amauchi, Yoshio Otahara, Kenji Nishimura, Tatsumi Morita
No abstract text is available yet for this article.
July 2004: Nihon Hoshasen Gijutsu Gakkai Zasshi
Noriko Otahara, Tetsuya Ikeda, Sumio Sakoda, Ryosuke Shiba, Toshikazu Nishimori
We investigated the involvement of N-methyl-D-aspartate (NMDA) glutamate receptor in the expression of the proteins Zif/268 and c-Fos elicited by painful stimuli. To this purpose, the effect of the administration of MK-801, an NMDA receptor antagonist, on Zif/268 and c-Fos expression following a noxious stimulus, represented by formalin injection into the whisker pad of rats, was examined in neurons of the trigeminal nucleus caudalis. Furthermore, the co-localization of formalin injection-evoked Zif/268 and c-Fos expression and subunit 1 of the NMDA receptor (NR1) was studied in this nucleus...
November 15, 2003: Brain Research Bulletin
No abstract text is available yet for this article.
1963: Acta Oto-laryngologica. Supplementum
Yumi Otahara, Takashi Izuno, Masayuki Tatemichi, Minoru Sugita
The absorption rate of cadmium (Cd) in the digestive organs is reported to be 0.5-8% in Friberg's textbook. This value was obtained from experimental studies. The object of the present study is to obtain the value from the Cd intake amount by ingestion, the Cd absorption amount by respiration and smoking, and the total Cd absorption amount calculated from the Cd accumulation amount in organs reported in articles including not only experimental but also epidemiologic studies conducted in Japan. The oral intake amounts of Cd in Japan were obtained from a published article to be 48 micrograms/day for males in the 1970s...
June 1, 2003: Journal of UOEH
Takashi Izuno, Minoru Sugita, Yumi Otahara, Katsumi Yoshida, Takashi Muto, Makoto Tamura, Tadao Miyakawa, Yutaka Inaba, Michiko Kurosawa, Hiroki Sugimori, Machi Suka
OBJECTIVE: The aim of this study was to determine priorities for specific intractable disease from the viewpoint of countermeasures. METHODS: A significance evaluation to provide a priority framework for intractable disease was performed with a questionnaire distributed to the staff of preventive medicine and public health departments of medical schools in Japan. To determine the actual conditions of these intractable diseases question were directed at the chairmen of individual clinical study groups...
July 2002: [Nihon Kōshū Eisei Zasshi] Japanese Journal of Public Health
Minoru Sugita, Yumi Otahara, Tomoko Fujishige, Kirika Sato, Akiko Tada, Mayumi Yamamoto, Yuko Takeoka, Masako Suzuki, Hisako Minowa, Yoji Hattori
Improving an unhealthy lifestyle decreases risk of incidence and death of lifestyle-related diseases. Consultation about a healthy lifestyle to recipients of health checkups conducted by public health nurses is one method for such improvement. The objective in the present study was to investigate the difference between consciousness of intervention by (1) the public health nurses who conducted consultations with recipients of health checkups and (2) the recipients who were consulted by the public health nurses...
May 2002: Journal of Epidemiology
Toshikazu Nishimori, Tetsuya Ikeda, Ryuji Terayama, Yasushi Ishida, Tadashi Nakamura, Noriko Otahara
Fos-like immunoreactivity (FLI) was investigated in the lumbar dorsal horn 2 h after transection of the rat sciatic nerve and sham operation. FLI following nerve transection was distributed through the medio-lateral extension of the superficial layer of the dorsal horn, while FLI after sham operation, tissue injury, was restricted to the lateral one-third of this layer. The number of FLI neurons in the lateral one-third was similar in the two operations, indicating that neurons expressing FLI in the medial two-thirds and in the lateral one-third of the superficial layer after nerve transection are derived from nerve injury and tissue injury, respectively...
April 26, 2002: Brain Research
M Sugita, T Izuno, M Tatemichi, Y Otahara
Many epidemiologic studies on the relationship between smoking and Parkinson's disease (PD) have been conducted. Morens et al. reviewed many articles in the study field and concluded that smoking is inversely associated with the risk of PD. In the present study, the object is to obtain summarized risk estimates of the relationship from the published articles using meta-analysis. Summarized risk estimates on the relationship between smoking and PD were found to be about 0.5 with statistical significance in meta-analysis...
March 2001: Journal of Epidemiology
T Izuno, M Sugita, S Arita, Y Otahara, I Nasu, K Tsuchiya, Y Hayashi
It is well known that cadmium (Cd) causes renal dysfunction such as increase of beta(2)-microglobulin excretion into urine. Although Cd in rice seems to be one of the largest sources of total Cd intake in Japan, there are very few studies that have epidemiologically clarified the relationship between Cd concentration in rice (Cd-R) and renal dysfunction, because such studies are basically ecological studies, in which confounding factors are difficult to take into consideration. To derive safety levels for foodstuff from Cd-R, it is essential to evaluate the effect of confounding factors...
November 2000: Environmental Research
M Nieto-Barrera
Myoclonic jerks occur in a number of different syndromes. There is many classifications of myoclonus. It is preferred the Fejerman classification, slightly modified that present the following five groups: 1. Myoclonus without encephalopathy and without epilepsy, which includes physiological myoclonus; 2. Encephalopathies with non epileptic myoclonus, which includes Kinsbourne syndrome and certain types of hyperekplexia which pose differential diagnosis problems with reflex myoclonic epilepsy; 3. Progressive encephalopathies with myoclonic seizures which includes typical and atypical progressive myoclonus epilepsies; 4...
February 1, 1999: Revista de Neurologia
L O Ferrer-Vidal
The author first reviews the definition of myoclonia as an epileptic crisis differentiated from tonic crises and infantile spasms. He reviews the prevalence and incidence found in bibliographic data, under the following headings 1. Early myoclonic encephalopathy or neonatal myoclonic encephalopathy 2. Early epileptic syndrome with bursts of suppression or Otahara's syndrome. 3. West's syndrome. 4. The benign myoclonic epilepsy syndrome of children. 6. Syndrome of myoclonic epilepsy in non-progressive encephalopathy...
February 1, 1999: Revista de Neurologia
M Sugita, T Izuno, M Kanamri, Y Otahara, H Kasuga
The summarized odds ratios of epidemiologic studies on the relationship between exposure to environmental tobacco smoke (ETS) and lung cancer by country were recalculated, using the odds ratio values in a 1992 report entitled, "Respiratory Health Effects of Passive Smoking: Lung Cancer and Other Disorders" by the US Environmental Protection Agency. The relationship between the summarized odds ratio and per capita gross national product (GNP) in 1964 was studied by the country. The graphic relationship between the summarized odds ratio (ordinate) and GNP (abscissa) showed an upward convex curve...
November 1998: Tokai Journal of Experimental and Clinical Medicine
M Omoto, T Imai, Y Otahara, S Tsukamoto, T Kanegae, K Nomoto
Histological effects of ethanol on the kidney were published in our previous report. In the present paper, results of the following measurement will be reported: contents of ethanol and related substances in the urine, both free and bound types, collected during the periods from 30 minutes to 11 hours after ethanol administration to rats, and ACE, alpha-GST, LPO, 25(OH)-D3, 1 alpha-25(OH)2-D3, 24, 25(OH)2-D3 in the serum of rats which had ethanol every day for a month. These will be reported together with histological observation of the kidney excised immediately after the blood sample was collected...
February 1997: Nihon Arukōru Yakubutsu Igakkai Zasshi, Japanese Journal of Alcohol Studies & Drug Dependence
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