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https://www.readbyqxmd.com/read/29786974/embryonic-exposure-to-environmentally-relevant-concentrations-of-a-brominated-flame-retardant-reduces-the-size-of-song-control-nuclei-in-a-songbird
#1
Margaret L Eng, Viktoria Winter, John E Elliott, Scott A MacDougall-Shackleton, Tony D Williams
Environmental contaminants have the potential to act as developmental stressors and impair development of song and the brain of songbirds, but they have been largely unstudied in this context. 2,2',4,4',5-Pentabromodiphenyl ether (BDE-99) is a brominated flame retardant congener that has demonstrated endocrine disrupting effects, and has pervaded the global environment. We assessed the effects of in ovo exposure to environmentally relevant levels of BDE-99 on the neuroanatomy of the song-control system in a model songbird species, the zebra finch (Taeniopygia guttata)...
May 22, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29786532/rice-body-formation-without-rheumatic-disease-or-tuberculosis-in-a-sausage-ring-finger
#2
M Cegarra-Escolano, C Jaloux, O Camuzard
Rice bodies are very unusual lesions, generally encountered in chronic synovitis due to rheumatoid diseases or tuberculosis. A 31-year-old right-handed man presented with a 15-year history of progressively growing "sausage-like" swelling of the 4th finger and palm of his right hand. There was an immovable, painless mass with restriction of the finger's ROM without local or general associated signs. Imaging showed a large non-aggressive mass within the tendon sheath. Complete excision of the mass was performed...
May 18, 2018: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/29786138/association-of-different-immunosuppressive-medications-with-periodontal-condition-in-patients-with-rheumatoid-arthritis-results-from-a-cross-sectional-study
#3
Dirk Ziebolz, Annegret Rupprecht, Jan Schmickler, Laura Bothmann, Juliane Krämer, Daniel Patschan, Gerhard A Müller, Rainer F Mausberg, Jana Schmidt, Gerhard Schmalz, Susann Patschan
BACKGROUND: The aim of this cross-sectional study was to investigate clinical periodontal findings as well as prevalence of selected potentially periodontal pathogenic bacteria in patients with rheumatoid arthritis (RA) treated with different immunosuppressive rheumatic medications. METHODS: 168 patients with RA undergoing different immunosuppressive medications were included and divided into subgroups according to their medication, which was taken in the past six months, in detail I) non-steroidal anti-inflammatory drugs (NSAID) and glucocorticoids combined, and II-VII) different disease modifying anti-rheumatic drugs (DMARDs): II) Methotrexate (MTX), III) Leflunomide, IV) MTX and TNF-α antagonists combined, V) Interleukin-6 (IL-6) antagonist, VI) MTX and Rituximab combined, and VII) combination therapies of more than two of these DMARDs...
May 22, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29785797/relationship-between-handgrip-strength-and-pulmonary-function-in-apparently-healthy-older-women
#4
Da-Hye Son, Ji-Won Yoo, Mi-Ra Cho, Yong-Jae Lee
OBJECTIVES: To investigate the relationship between handgrip strength and pulmonary function. DESIGN: Cross-sectional study of a representative sample of older Korean women. SETTING: The Korean National Health and Nutrition Examination Survey. PARTICIPANTS: Community-dwelling women aged 65 and older without chronic diseases or pulmonary disease (N=605). MEASUREMENTS: Handgrip strength was measured using a digital hand dynamometer, and pulmonary function was tested according to guidelines of the American Thoracic Society/European Respiratory Society using a spirometry system...
May 21, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29785588/sam68-promotes-invasion-migration-and-proliferation-of-fibroblast-like-synoviocytes-by-enhancing-the-nf-%C3%AE%C2%BAb-p65-pathway-in-rheumatoid-arthritis
#5
Weiwei Sun, Rongqin Qin, Rui Wang, Dazhi Ding, Zhaohui Yu, Yuxi Liu, Ruilong Hong, Zhen Cheng, Youhua Wang
Src-associated substrate during mitosis of 68 KDa (Sam68), also known as KH domain containing, RNA binding, signal transduction associated 1 (KHDRBS1), is the prototypic member of the signal transduction activator of RNA (STAR) family of RNA-binding proteins. Previous studies have indicated that Sam68 regulates nuclear transcription factor kappa B (NF-κB) to mediate inflammation. In this study, we analyzed the effect and possible mechanisms of Sam68 in rheumatoid arthritis (RA). By western blot analysis and immunohistochemistry, we found that the expression of Sam68 in synovial tissue of RA patients was increased compared with the control group...
May 21, 2018: Inflammation
https://www.readbyqxmd.com/read/29785401/rheumatoid-arthritis-and-mirnas-a-critical-review-through-a-functional-view
#6
REVIEW
Maria Cristina Moran-Moguel, Stefania Petarra-Del Rio, Evangelina E Mayorquin-Galvan, Maria G Zavala-Cerna
Rheumatoid arthritis (RA) is a systemic autoimmune disease with severe joint inflammation and destruction associated with an inflammatory environment. The etiology behind RA remains to be elucidated; most updated concepts include the participation of environmental, proteomic, epigenetic, and genetic factors. Epigenetic is considered the missing link to explain genetic diversification among RA patients. Within epigenetic factors participating in RA, miRNAs are defined as small noncoding molecules with a length of approximately 22 nucleotides, capable of gene expression modulation, either negatively through inhibition of translation and degradation of the mRNA or positively through increasing the translation rate...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29785211/a-very-rare-cause-of-lower-limb-ischemia-in-young-people-popliteal-artery-entrapment
#7
Hasan Baki Altinsoy, Ozkan Alatas, Emjed Khalil, Kenan Abdurrahman Kara, Candan Cudi Okten, Omer Faruk Dogan
Background: Popliteal artery entrapment syndrome (PAES) is a very rare pathology that can cause lower extremity ischemia in healthy young people. Anomalous anatomic relationships between the popliteal artery (PA) and the surrounding musculo-tendinous structures cause PAES. We present 31 patients with PAES in 35 limbs that were treated surgically in our clinic within a 12-year period. Patients and Methods: From 2001 to 2015, 31 patients (mean age: 32 ± 7.4 years) underwent surgery for PAES...
2018: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/29785208/developing-cellulolytic-yarrowia-lipolytica-as-a-platform-for-the-production-of-valuable-products-in-consolidated-bioprocessing-of-cellulose
#8
Zhong-Peng Guo, Julien Robin, Sophie Duquesne, Michael Joseph O'Donohue, Alain Marty, Florence Bordes
Background: Both industrial biotechnology and the use of cellulosic biomass as feedstock for the manufacture of various commercial goods are prominent features of the bioeconomy. In previous work, with the aim of developing a consolidated bioprocess for cellulose bioconversion, we conferred cellulolytic activity of Yarrowia lipolytica , one of the most widely studied "nonconventional" oleaginous yeast species. However, further engineering this strain often leads to the loss of previously introduced heterologous genes due to the presence of multiple LoxP sites when using Cre -recombinase to remove previously employed selection markers...
2018: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29785201/speed-breeding-for-multiple-quantitative-traits-in-durum-wheat
#9
Samir Alahmad, Eric Dinglasan, Kung Ming Leung, Adnan Riaz, Nora Derbal, Kai P Voss-Fels, Jason A Able, Filippo M Bassi, Jack Christopher, Lee T Hickey
Background: Plant breeding requires numerous generations to be cycled and evaluated before an improved cultivar is released. This lengthy process is required to introduce and test multiple traits of interest. However, a technology for rapid generation advance named 'speed breeding' was successfully deployed in bread wheat ( Triticum aestivum L.) to achieve six generations per year while imposing phenotypic selection for foliar disease resistance and grain dormancy. Here, for the first time the deployment of this methodology is presented in durum wheat ( Triticum durum Desf...
2018: Plant Methods
https://www.readbyqxmd.com/read/29784872/sirt1-inhibits-rheumatoid-arthritis-fibroblast-like-synoviocyte-aggressiveness-and-inflammatory-response-via-suppressing-nf-%C3%AE%C2%BAb-pathway
#10
Guoqing Li, Zhongbing Xia, Ying Liu, Fanru Meng, Xia Wu, Yuxuan Fang, Chunwang Zhang, Dan Liu
Rheumatoid arthritis (RA) is an autoimmune disease of the joints characterized by synovial hyperplasia and chronic inflammation. Fibroblast-like synoviocytes (FLS) play a central role in RA initiation, progression, and perpetuation. Prior studies showed that sirtuin 1(SIRT1), a deacetylase participating in a broad range of transcriptional and metabolic regulations, may impact cell proliferation and inflammatory responses. However, the role of SIRT1 in RA-FLS was unclear. Here, we explored the effects of SIRT1 on the aggressiveness and inflammatory responses of cultured RA-FLS...
May 21, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29784328/determination-of-endrin-and-%C3%AE-keto-endrin-in-five-food-products-of-animal-origin-using-gc-%C3%AE-ecd-a-modified-quechers-approach-to-traditional-detection
#11
Md Musfiqur Rahman, Han Sol Lee, A M Abd El-Aty, Md Humayun Kabir, Hyung Suk Chung, Jong-Hyouk Park, Mi-Ra Kim, Ji-Hyun Kim, Ho-Chul Shin, Sung Shik Shin, Jae-Han Shim
A simple quick, easy, cheap, effective, rugged, and safe (QuEChERS)-based method was developed for the analysis of endrin and its metabolite, δ-keto endrin, in five animal-derived food products (chicken, pork, beef, egg, and milk) using a gas chromatography-micro electron capture detector (GC-μECD). Samples were extracted with acidified acetonitrile, salted out with magnesium sulfate and sodium acetate, and finally purified with a dual layer solid-phase extraction cartridge (SPE) that contains both Supelclean ENVI-Carb (upper layer) and primary secondary amine (lower layer) SPE sorbents...
October 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29784052/the-effect-of-heart-failure-and-left-ventricular-assist-device-treatment-on-right-ventricular-mechanics-a-computational-study
#12
Jun I K Park, Aulia Khamas Heikhmakhtiar, Chang Hyun Kim, Yoo Seok Kim, Seong Wook Choi, Kwang Soup Song, Ki Moo Lim
BACKGROUND AND AIMS: Although it is important to analyze the hemodynamic factors related to the right ventricle (RV) after left ventricular assist device (LVAD) implantation, previous studies have focused only on the alteration of the ventricular shape and lack quantitative analysis of the various hemodynamic parameters. Therefore, we quantitatively analyzed various hemodynamic parameters related to the RV under normal, heart failure (HF), and HF incorporated with continuous flow LVAD therapy by using a computational model...
May 22, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29783731/-lactobacillus-plantarum-strain-ln4-attenuates-diet-induced-obesity-insulin-resistance-and-changes-in-hepatic-mrna-levels-associated-with-glucose-and-lipid-metabolism
#13
Eunjung Lee, So-Ra Jung, So-Young Lee, Na-Kyoung Lee, Hyun-Dong Paik, Seong-Il Lim
The prevalence of obesity and associated metabolic disorders, including diabetes and cardiovascular disease, is rapidly becoming a severe global health problem. Recent reports have suggested that the alteration of the gut ecosystem through the consumption of probiotics and fermented foods, such as yogurt and Kimchi, can significantly impact obesity and Type 2 diabetes (T2D)-related biomarkers. In this study, we screened over 400 strains of lactic acid bacteria (LAB) that were isolated from fermented foods to identify potent anti-obesogenic and diabetic probiotics in vitro...
May 19, 2018: Nutrients
https://www.readbyqxmd.com/read/29783696/jatrorrhizine-hydrochloride-suppresses-proliferation-migration-and-secretion-of-synoviocytes-in-vitro-and-ameliorates-rat-models-of-rheumatoid-arthritis-in-vivo
#14
Haiwen Qiu, Shengnan Sun, Xuemei Ma, Congcong Cui, Gang Chen, Zhenzhou Liu, Hui Li, Mei Liu
Jatrorrhizine hydrochloride (JH), an active component isolated from the traditional Chinese herb Coptis chinensis , has been reported to have antimicrobial, antitumor, antihypercholesterolemic, and neuroprotective activities. However, its antirheumatoid arthritis (RA) property remains unknown. In this study, a collagen-induced arthritis (CIA) rat model was used to evaluate the therapeutic effects of JH on RA by using arthritis score, radiological evaluation, and histopathological assessment. The in vitro effects of JH on proliferation, migration, and production of inflammatory mediators in RA-derived fibroblast-like synoviocyte MH7A cells were determined by the EdU incorporation assay, wound healing assay, real-time PCR, and ELISA, respectively...
May 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29783196/activity-concentrations-of-238-u-and-226-ra-in-two-european-black-shales-and-their-experimentally-derived-leachates
#15
Franziska D H Wilke, Georg Schettler, Andrea Vieth-Hillebrand, Michael Kühn, Heike Rothe
The production of gas from unconventional resources became an important position in the world energy economics. In 2012, the European Commission's Joint Research Centre estimate 16 trillion cubic meters (Tcm) of technically recoverable shale gas in Europe. Taking into account that the exploitation of unconventional gas can be accompanied by serious health risks due to the release of toxic chemical components and natural occurring radionuclides into the return flow water and their near-surface accumulation in secondary precipitates, we investigated the release of U, Th and Ra from black shales by interaction with drilling fluids containing additives that are commonly employed for shale gas exploitation...
May 18, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29782593/-18-f-fdg-pet-ct-joint-assessment-of-early-therapeutic-response-in-rheumatoid-arthritis-patients-treated-with-rituximab
#16
Pacôme Fosse, Marie-Joelle Kaiser, Gauthier Namur, Dominique de Seny, Michel G Malaise, Roland Hustinx
Background: 18 F-FDG PET/CT has been proposed in the evaluation of the disease activity in rheumatoid arthritis (RA). The goals of this study were to evaluate the reproducibility of the technique, to compare metabolic parameters to clinical, biological and ultrasonographic parameters before and after treatment and to evaluate whether the early metabolic response was related to the outcome. 18 F- FDG PET/CT of the hands, wrists and knees was obtained in 15 patients with anti-TNFα refractory RA, at baseline and 16 weeks after treatment with rituximab...
2018: European journal of hybrid imaging
https://www.readbyqxmd.com/read/29782424/the-profile-of-serum-transferrin-isoforms-in-rheumatoid-arthritis
#17
Monika Gudowska, Ewa Gruszewska, Alicja Wrona, Ewa Gindzienska-Sieskiewicz, Izabela Domyslawska, Karina Lipartowska-Klimuk, Bogdan Cylwik, Stanislaw Sierakowski, Lech Chrostek
INTRODUCTION: Transferrin, a microheterogeneous iron-transporting N-glycoprotein, is an optimal model for the analysis of the glycosylation profile in rheumatoid arthritis. The aim of this study was to assess the transferrin isoforms profile in RA patients at the time of diagnosis and then look into the associations with disease activity. METHODS: Serum samples were collected from 48 patients with rheumatoid arthritis. The patients were males (6) and females (42) (age range: 33-85 years)...
May 19, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29781829/comparison-of-adults-with-polyarticular-juvenile-idiopathic-arthritis-to-adults-with-rheumatoid-arthritis-a-cross-sectional-analysis-of-clinical-features-and-medication-use
#18
Danielle M Feger, Nicholas Longson, Hiranda Dodanwala, Barbara E Ostrov, Nancy J Olsen, Rayford R June
BACKGROUND/OBJECTIVE: Many individuals with juvenile idiopathic arthritis (JIA) have persistent disease into adulthood. Polyarticular JIA (pJIA) is often mislabeled as rheumatoid arthritis (RA) in adult rheumatology clinics, and treatment for adult pJIA patients is not well defined. We aimed to describe clinical features and medication use in the adult pJIA population in relation to an RA control cohort. METHODS: We performed a cross-sectional study of 45 adults with pJIA and 94 with RA seen from 2013 to 2017...
May 17, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29781582/sphingosine-1-phosphate-receptor-1-signaling-maintains-endothelial-cell-barrier-function-and-protects-against-immune-complex-induced-vascular-injury
#19
Nathalie Burg, Steven Swendeman, Stefan Worgall, Timothy Hla, Jane E Salmon
OBJECTIVE: Immune complex (IC) deposition activates neutrophils (PMN), increases vascular permeability and leads to organ damage in SLE and RA. The bioactive lipid sphingosine-1-phosphate (S1P), acting via S1P receptor 1 (S1P1 ), is a key regulator of endothelial cell (EC) barrier function. We hypothesized that augmenting EC integrity via S1P1 signaling would attenuate inflammatory injury mediated by ICs. METHODS: In vitro barrier function was assessed in human umbilical vein endothelial cells (HUVECs) by Electric Cell-substrate Impedance Sensing (ECIS)...
May 21, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29781581/brain-correlates-of-continuous-pain-in-rheumatoid-arthritis-as-measured-by-pulsed-arterial-spin-labeling
#20
Yvonne C Lee, Alexander Fine, Ekaterina Protsenko, Elena Massarotti, Robert R Edwards, Ishtiaq Mawla, Vitaly Napadow, Marco L Loggia
OBJECTIVE: Central nervous system pathways involving pain modulation shape the pain experience in patients with chronic pain. Our objectives were to understand the mechanisms underlying pain in rheumatoid arthritis (RA) and identify brain signals that may serve as imaging markers for developing targeted treatments for RA pain. METHODS: Subjects with RA and matched controls underwent functional magnetic resonance imaging, using pulsed arterial spin labeling (pASL)...
May 21, 2018: Arthritis Care & Research
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