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https://www.readbyqxmd.com/read/28441721/pathogenic-or-therapeutic-extracellular-vesicles-in-rheumatic-diseases-role-of-mesenchymal-stem-cell-derived-vesicles
#1
REVIEW
Stella Cosenza, Maxime Ruiz, Marie Maumus, Christian Jorgensen, Danièle Noël
Extracellular vesicles (EVs) are important mediators of cell-to-cell communication pathways via the transport of proteins, mRNA, miRNA and lipids. There are three main types of EVs, exosomes, microparticles and apoptotic bodies, which are classified according to their size and biogenesis. EVs are secreted by all cell types and their function reproduces that of the parental cell. They are involved in many biological processes that regulate tissue homeostasis and physiopathology of diseases. In rheumatic diseases, namely osteoarthritis (OA) and rheumatoid arthritis (RA), EVs have been isolated from synovial fluid and shown to play pathogenic roles contributing to progression of both diseases...
April 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28441353/matrix-metalloproteinase-gene-activation-resulting-from-disordred-epigenetic-mechanisms-in-rheumatoid-arthritis
#2
REVIEW
Yasuto Araki, Toshihide Mimura
Matrix metalloproteinases (MMPs) are implicated in the degradation of extracellular matrix (ECM). Rheumatoid arthritis (RA) synovial fibroblasts (SFs) produce matrix-degrading enzymes, including MMPs, which facilitate cartilage destruction in the affected joints in RA. Epigenetic mechanisms contribute to change in the chromatin state, resulting in an alteration of gene transcription. Recently, MMP gene activation has been shown to be caused in RASFs by the dysregulation of epigenetic changes, such as histone modifications, DNA methylation, and microRNA (miRNA) signaling...
April 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28440799/corrigendum-kif3a-binds-to-%C3%AE-arrestin-for-suppressing-wnt-%C3%AE-catenin-signalling-independently-of-primary-cilia-in-lung-cancer
#3
Minsuh Kim, Young-Ah Suh, Ju-Hee Oh, Bo Ra Lee, Joon Kim, Se Jin Jang
No abstract text is available yet for this article.
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28440680/efficacy-and-safety-of-baricitinib-in-japanese-patients-with-active-rheumatoid-arthritis-a-52-week-randomized-single-blind-extension-study
#4
Yoshiya Tanaka, Taeko Ishii, Zhihong Cai, Douglas Schlichting, Terence Rooney, William Macias
OBJECTIVES: The objective of this study is to evaluate the efficacy and safety of long-term (64 weeks; 52-week extension of a 12-week study) baricitinib treatment in Japanese patients with active rheumatoid arthritis (RA) despite methotrexate therapy. METHODS: Patients (N = 145) with active RA were randomized to placebo, 1mg, 2mg, 4mg, or 8mg baricitinib for the first 12 weeks. During the 52-week extension period, patients on 4mg or 8mg baricitinib remained on the same dose and all other patients were re-randomized to 4mg or 8mg baricitinib...
April 25, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28440561/anterior-st-elevation-myocardial-infarction-induced-by-rituximab-infusion-a-case-report-and-review-of-the-literature
#5
K Sharif, A Watad, N L Bragazzi, E Asher, A Abu Much, Y Horowitz, M Lidar, Y Shoenfeld, H Amital
WHAT IS KNOWN AND OBJECTIVES: Rituximab is a chimeric monoclonal anti-CD20 antibody approved for the treatment of some lymphoid malignancies as well as for autoimmune diseases including rheumatoid arthritis (RA), idiopathic thrombocytopenic purpura (ITP) and vasculitis. Generally, rituximab is well tolerated; nevertheless, some patients develop adverse effects including infusion reactions. Albeit rare, these reactions may in some cases be life-threatening conditions. Rituximab cardiovascular side effects include more common effects such as hypertension, oedema and rare cases of arrhythmias and myocardial infarction...
June 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28440447/anti%C3%A2-inflammatory-effects-of-oxymatrine-on-rheumatoid-arthritis-in-rats-via-regulating-the-imbalance-between-treg-and-th17-cells
#6
Ailing Ma, Yongya Yang, Qiuyang Wang, Yin Wang, Jing Wen, Yanli Zhang
Oxymatrine (OMT), a monosomic alkaloid extracted from the Chinese herb, Sophora flavescens Ait, has long been used as a traditional Chinese medicine for the treatment of inflammatory diseases. The aim of the present study was to investigate the potential anti‑inflammatory effect of OMT, and its modulation on imbalance between regulatory T (Treg) cells and T helper (Th) 17 cells in rats with collagen‑induced arthritis (CIA). Sprague‑Dawley rats were immunized with type II collagen and following a second collagen immunization, the rats were treated with OMT or dexamethasone (DXM) intraperitoneally once a day for 43 days...
April 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28440350/high-frequency-ultrasonography-of-the-hand-versus-anti-ra33-evaluation-in-early-rheumatoid-arthritis-a-pilot-study
#7
Andreea Lili Barbulescu, Paulina Lucia Ciurea, Carmen Mitran, Beatrice Andreea Chisalau, Cristina Dorina Parvanescu, Sineta Cristina Firulescu, Maria Balasoiu, Mihail Virgil Boldeanu, Horatiu Popoviciu, Florentin Ananu Vreju
AIM: Accurate diagnosis and early treatment in rheumatoid arthritis (RA) can lead to a good outcome and a correct management of the disease. We aimed toinvestigate the prognostic value of anti-RA33 antibodies, by evaluating the relationship with ultrasonographic (US) findings in patients with early RA. MATERIAL AND METHODS: We performed a prospective study which included 29 patients, diagnosed with early RA according to the ACR/EULAR 2010 criteria and 21 sex and age-matched control subjects...
April 22, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/28440025/identifying-key-genes-in-rheumatoid-arthritis-by-weighted-gene-co-expression-network-analysis
#8
Chunhui Ma, Qi Lv, Songsong Teng, Yinxian Yu, Kerun Niu, Chengqin Yi
PURPOSE: This study aimed to identify rheumatoid arthritis (RA) related genes based on microarray data using the WGCNA (weighted gene co-expression network analysis) method. METHODS: Two gene expression profile datasets GSE55235 (10 RA samples and 10 healthy controls) and GSE77298 (16 RA samples and seven healthy controls) were downloaded from Gene Expression Omnibus database. Characteristic genes were identified using metaDE package. WGCNA was used to find disease-related networks based on gene expression correlation coefficients, and module significance was defined as the average gene significance of all genes used to assess the correlation between the module and RA status...
April 25, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28439964/global-and-targeted-metabolomics-of-synovial-fluid-discovers-special-osteoarthritis-metabolites
#9
Kaidi Zheng, Shanmin Ni, Huaijun Chen, Shenmin Lou, Mengting Hu, Li Sun, Xinyu Yang
PURPOSE: To identify special metabolites in synovial fluid of osteoarthritis (OA) via a metabolomics approach. METHOD: Synovial fluid of 35 participants (25 OA patients and 10 controls) was detected by GC-TOF/MS and multivariate data analysis was applied to analyze correlation among the observations. Different metabolites were screened by VIP value (VIP > 1), student t test (p < 0.05), and fold change (fold > 1.5), and verified with the standard metabolites in the synovial fluid of 24 OA patients and 11 controls by LC/MS...
April 25, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28439957/prognostic-indicators-in-pediatric-clinically-isolated-syndrome
#10
Pietro Iaffaldano, Marta Simone, Giuseppe Lucisano, Angelo Ghezzi, Gabriella Coniglio, Vincenzo Brescia Morra, Giuseppe Salemi, Francesco Patti, Alessandra Lugaresi, Guillermo Izquierdo, Roberto Bergamaschi, Jose Antonio Cabrera-Gomez, Carlo Pozzilli, Enrico Millefiorini, Raed Alroughani, Cavit Boz, Eugenio Pucci, Giovanni Bosco Zimatore, Patrizia Sola, Giacomo Lus, Davide Maimone, Carlo Avolio, Eleonora Cocco, Seyed Aidin Sajedi, Gianfranco Costantino, Pierre Duquette, Vahid Shaygannejad, Thor Petersen, Ricardo Fernández Bolaños, Damiano Paolicelli, Carla Tortorella, Tim Spelman, Lucia Margari, Maria Pia Amato, Giancarlo Comi, Helmut Butzkueven, Maria Trojano
OBJECTIVE: To assess prognostic factors for a second clinical attack and a first disability worsening event in pediatric clinically isolated syndrome (pCIS) suggestive of Multiple Sclerosis (MS) patients. METHODS: A cohort of 770 pCIS patients was followed-up for at least 10 years. Cox proportional hazard models and RECursive Partitioning and AMalgamation (RECPAM) tree-regression were used to analyze data. RESULTS: In pCIS, female sex and a multifocal onset were risk factors for a second clinical attack (HR, 95% CI: 1...
April 25, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28439057/-calcium-and-bone-metabolism-across-women-s-life-stages-osteoporosis-in-female-patients-with-rheumatoid-arthritis
#11
Takefumi Furuya
Female patients with rheumatoid arthritis(RA)are at high risk for osteoporosis and fractures. In Japanese female patients with RA, age, disability, daily prednisolone dose, history of total knee replacement, and low bone mineral density are known to be risk factors for fractures, and more than 70% are reported to be vitamin D deficiency.
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28438552/immunomodulation-of-autoimmune-arthritis-by-pro-inflammatory-cytokines
#12
REVIEW
Eugene Y Kim, Kamal D Moudgil
Pro-inflammatory cytokines promote autoimmune inflammation and tissue damage, while anti-inflammatory cytokines help resolve inflammation and facilitate tissue repair. Over the past few decades, this general feature of cytokine-mediated events has offered a broad framework to comprehend the pathogenesis of autoimmune and other immune-mediated diseases, and to successfully develop therapeutic approaches for diseases such as rheumatoid arthritis (RA). Anti-tumor necrosis factor-α (TNF-α) therapy is a testimony in support of this endeavor...
April 21, 2017: Cytokine
https://www.readbyqxmd.com/read/28438483/what-role-does-rheumatoid-arthritis-disease-activity-have-in-cardiovascular-risk
#13
Marco Aurelio Ramírez Huaranga, María Dolores Mínguez Sanchez, Miguel Ángel Zarca Diaz de la Espina, Pedro José Espinoza Pardos, Guillermo Romero Aguilera
Rheumatoid arthritis (RA) is associated with a 1.3 to 3-fold increase in mortality, being the major cause of death from cardiovascular complications (40%-50%). Therefore, the initial approach should include cardiovascular risk (CVR) assessment using algorithms adapted for this population. Although, SCOREM is an important advance, there are data indicating that subclinical atherosclerosis may be underdiagnosed. OBJECTIVE: To estimate the strength of association between carotid ultrasound and SCOREM in this population, as well as the implication of disease activity...
April 21, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28437846/pain-sensitization-is-associated-with-disease-activity-in-rheumatoid-arthritis-patients-a-cross-sectional-study
#14
Yvonne C Lee, Clifton O Bingham, Robert R Edwards, Wendy Marder, Phillips Kristine, Marcy B Bolster, Daniel J Clauw, Larry W Moreland, Bing Lu, Alyssa Wohlfahrt, Zhi Zhang, Tuhina Neogi
OBJECTIVE: Pain sensitization may contribute to pain severity in rheumatoid arthritis (RA), impacting assessment of disease activity. We examined whether pain processing mechanisms were associated with disease activity among RA patients with active disease. METHODS: This study includes 139 subjects enrolled in the Central Pain in Rheumatoid Arthritis cohort. Subjects underwent quantitative sensory testing (QST), including assessment of pressure pain thresholds (PPTs) at multiple sites, conditioned pain modulation, and temporal summation...
April 24, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28437600/how-are-behavioral-theories-used-in-interventions-to-promote-physical-activity-in-rheumatoid-arthritis-a-systematic-review
#15
Ingrid Demmelmaier, Maura D Iversen
OBJECTIVES: To identify the use of behavioral theories (BTs) in physical activity (PA) interventions in populations with RA. METHODS: This review includes articles published in English between 01-01-1980 and 08-12-2015 in MEDLINE, Cochrane and CINAHL identified by a strategic literature search. Included studies were: published in international peer-reviewed journals; mentioned "theory", evaluated a PA intervention for adults with RA; and had ≥ 1 PA variable as the outcome...
April 24, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28437346/correlations-between-sagittal-spinal-balance-and-quality-of-life-in-rheumatoid-arthritis
#16
Hong Seok Lee, Jung Sub Lee, Jong Ki Shin, Tae Sik Goh
STUDY DESIGN: Prospective study. OBJECTIVE: To identify relationships between spinopelvic parameters and health-related quality of life in rheumatoid arthritis (RA). SUMMARY OF BACKGROUND DATA: Little data are available on relationships between sagittal spinopelvic parameters and health-related quality of life in RA. MATERIALS AND METHODS: The study and control groups comprised 120 RA patients and 60 controls. All subjects underwent anteroposterior and lateral radiography of the whole spine, including hip joints, and all completed clinical questionnaires...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28436643/ultrathin-in2o3-nanosheets-with-uniform-mesopores-for-highly-sensitive-nitric-oxide-detection
#17
Xue Wang, Juan Su, Hui Chen, Guo-Dong Li, Zhifang Shi, Haifeng Zou, Xiaoxin Zou
Nitric oxide (NOx, including NO and NO2) is one of the most dangerous environmental toxins and pollutants, mainly origins from vehicle exhaust and industrial emission. The development of sensitive NOx gas sensors is quite urgent for human health and environmental friendly. Up to now, it still remains a great challenge to develop NOx gas sensor, which can satisfy multiple application demands for sensing performance (such as high response, low detection temperature and limit). In this work, ultrathin In2O3 nanosheets with uniform mesopores were successfully synthesized through a facile two-step synthetic method...
April 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28436448/elevated-circulating-levels-of-the-interferon-%C3%AE-induced-chemokines-are-associated-with-disease-activity-and-cutaneous-manifestations-in-adult-onset-still-s-disease
#18
Jae Ho Han, Chang-Hee Suh, Ju-Yang Jung, Mi-Hyun Ahn, Mi Hwa Han, Ji Eun Kwon, Hyunee Yim, Hyoun-Ah Kim
C-X-C motif chemokine 9 (CXCL9), CXCL10, and CXCL11 are produced in response to interferon-γ (IFN-γ) and trigger inflammation with the accumulation of activated lymphocytes. It appears that these chemokines could play a role in the pathogenesis of adult-onset Still's disease (AOSD). Therefore, we investigated the associations between the levels of these chemokine and clinical manifestations in patients with active AOSD. Serum levels of IFN-γ, CXCL9, CXCL10 and CXCL11 were determined using enzyme-linked immunosorbent assays...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28436114/all-trans-retinoic-acid-stimulates-overexpression-of-tumor-protein-d52-tpd52-isoform-3-and-neuronal-differentiation-of-imr-32-cells
#19
Sudha Sravanti Kotapalli, Chandrashekhar Dasari, Divya Duscharla, Karthik Reddy Kami Reddy, Manjula Kasula, Ramesh Ummanni
Tumor protein D52 (TPD52), a proto-oncogene is overexpressed in a variety of epithelial carcinomas and plays an important role in cell proliferation, migration and cell death. In the present study we found that the treatment of IMR-32 neuroblastoma (NB) cells with retinoic acid (RA) stimulates an increase in expression of TPD52. TPD52 expression is detectable after 72 h, can be maintained till differentiation of NB cells suggesting that TPD52 is involved in differentiation. Here, we demonstrate that TPD52 is essential for RA to promote differentiation of NB cells...
April 24, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28435624/metal-stain-on-monolithic-zirconia-restoration-a-case-report
#20
Min-Sang Cha, Sang-Woon Lee, Yoon-Hyuk Huh, Lee-Ra Cho, Chan-Jin Park
In restorative treatment using fixed dental prostheses, dentists should select appropriate restoration material among various types of dental materials. The strength, marginal fit, esthetics, wear resistance, biocompatibility, and cost are important factors in the choice of restoration materials. The present case showed a surface stain on a monolithic zirconia restoration that was due to wear between the monolithic zirconia restoration and the base metal alloy restoration. This phenomenon was confirmed by surface roughness measurement and electron probe micro-analysis...
April 2017: Journal of Advanced Prosthodontics
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