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https://www.readbyqxmd.com/read/29228807/trends-in-carisoprodol-abuse-and-misuse-after-regulatory-scheduling-a-retrospective-review-of-california-poison-control-calls-from-2008-to-2015
#1
Christie Sun, Kathryn A Hollenbach, F L Cantrell
BACKGROUND: In January 2012, carisoprodol was classified as a Schedule IV substance under the controlled substances act from a previously non-controlled, non-scheduled classification. Carisoprodol is marketed as a skeletal muscle relaxant and is commonly cited for its abuse potential. OBJECTIVES: We aimed to compare volume of calls involving carisoprodol abuse or misuse to a statewide poison control system before and after the scheduling change. METHODS: Data were extracted from poison control calls coded as "misuse/abuse" involving carisoprodol from four years before (2008 to 2011) and four years after (2012 to 2015) the scheduling change...
December 12, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/29228767/revealing-electron-electron-interactions-within-lewis-pairs-in-chemical-systems
#2
Adam Jonathan Proud, Brendan James Henry Sheppard, Jason Kenneth Pearson
The so-called "Lewis Pair" is a ubiquitous phenomenon in chemistry and is often used as an intuitive construct to predict and rationalize chemical structure and behaviour. Concepts from the very general Valence Shell Electron Pair Repulsion (VSEPR) model to the most esoteric reaction mechanism routinely rely on the notion that electrons tend to exist in pairs and that these pairs can be thought of as being localized to a particular region of space. It is precisely this localization that allows one to intuit how these pairs might behave, generally speaking, so that reasonable predictions may be made regarding molecular structure, intermolecular interactions, property trends, and reaction mechanisms, etc...
December 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29227200/telepsychiatry-for-children-and-adolescents-a-review-of-the-prometted-project
#3
Catherine M Doyen, Marie-Joëlle Oreve, Eric Desailly, Virginie Goupil, Kevin Zarca, Yann L'Hermitte, Pauline Chaste, Marie-Ode Bau, Didier Beaujard, Sliman Haddadi, Ana Bibay, Yves Contejean, Marie-Thérèse Coutrot, Liora Crespin, Isabelle Frioux, Mario Speranza, Nolwenn Francois, Kelley Kaye
BACKGROUND: Telemedicine for children and adolescents is a public health topic, and since 2009 in France, the legal framework defines practical modalities. Some children with Attention Deficit with or without Hyperactivity Disorder, social anxiety, or Autism Spectrum Disorder (ASD) can be easily engaged within a teleconsultation model. Literature suggests new opportunities to facilitate the care process for the ASD person and his family: diagnosis with the use of validated instruments and parental accompaniment...
December 11, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29226894/identifying-undiagnosed-or-undertreated-patients-with-familial-hypercholesterolemia-from-the-laboratory-records-of-a-tertiary-medical-center
#4
Cem Haymana, Hamza Berlik, Yalçın Güneş, Orhan Enes Tunçez, Cihat Aytekin, Zafer Tapıkara, Hüseyin Güzel, Özlem Öztürk, Cem Barçın, Taner Özgürtaş, Ömer Azal, Alper Sönmez
OBJECTIVE: Familial hypercholesterolemia (FH) is a life-threatening genetic disease associated with elevated low-density lipoprotein cholesterol (LDL-C) and premature coronary heart disease that is undiagnosed and undertreated around the world. This study aimed to examine the demographic characteristics, awareness, and treatment adherence of undiagnosed or undertreated FH patients based on laboratory records. METHODS: In a 16-month retrospective survey using laboratory records, patients with elevated LDL-C (>250 mg/dL) were identified (n=395)...
December 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29226821/patterns-of-civilian-and-child-deaths-due-to-war-related-violence-in-syria-a-comparative-analysis-from-the-violation-documentation-center-dataset-2011-16
#5
Debarati Guha-Sapir, Benjamin Schlüter, Jose Manuel Rodriguez-Llanes, Louis Lillywhite, Madelyn Hsiao-Rei Hicks
BACKGROUND: Since March, 2011, the Syrian civil war has lowered life expectancy by as much as 20 years. We describe demographic, spatial, and temporal patterns of direct deaths of civilians and opposition combatants from conflict-related violence in 6 years of war. METHODS: We analysed conflict-related violent deaths with complete information on date, place, and cause of death and demographic group occurring from March 18, 2011, to Dec 31, 2016, recorded by the Violation Documentation Center (VDC)...
November 29, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/29226222/learning-processes-and-learning-problems-in-german-postgraduate-medical-education
#6
Hendrik van den Bussche, Lea Krause-Solberg, Martin Scherer, Stine Ziegler
Objective: In order to evaluate the quality of postgraduate medical education in Germany, we examined how the learning of theoretical and practical competencies is conceptualized and how the learning process takes place in real terms. The training conditions, as perceived by medical residents, are compared with the learning objectives, as stated by the Federal Chamber of Physicians in its regulation on postgraduate education. The analysis is based on the data of the "KarMed" study (abbreviation of "career progression and career breaks among physicians during postgraduate education"), a multicentre cohort study of medical school graduates from seven universities who arre followed until they receive their licenses as specialist physicians...
2017: GMS Journal for Medical Education
https://www.readbyqxmd.com/read/29223194/hospital-confirmed-acute-myocardial-infarction-prehospital-identification-using-the-medical-priority-dispatch-system
#7
Jeff J Clawson, Isabel Gardett, Greg Scott, Conrad Fivaz, Tracey Barron, Meghan Broadbent, Christopher Olola
Introduction Early recognition of an acute myocardial infarction (AMI) can increase the patient's likelihood of survival. As the first point of contact for patients accessing medical care through emergency services, emergency medical dispatchers (EMDs) represent the earliest potential identification point for AMIs. The objective of the study was to determine how AMI cases were coded and prioritized at the dispatch point, and also to describe the distribution of these cases by patient age and gender. Hypothesis/Problem No studies currently exist that describe the EMD's ability to correctly triage AMIs into Advanced Life Support (ALS) response tiers...
December 10, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29222362/randomized-controlled-evaluation-of-an-insulin-pen-storage-policy
#8
Haley G Gibbs, Tara McLernon, Rosemary Call, Katie Outten, Leigh Efird, Peter A Doyle, Elizabeth A Stuart, Nestoras Mathioudakis, Nicole Glasgow, Avadhut Joshi, Pravin George, Bob Feroli, Elizabeth K Zink
PURPOSE: Results of a quality-improvement project to enhance safeguards against "wrong-pen-to-patient" insulin pen errors by permitting secure bedside storage of insulin pens are reported. METHODS: A cluster-randomized controlled evaluation was conducted at an academic medical center to assess adherence with institutional policy on insulin pen storage before and after implementation of a revised policy allowing pen storage in locking boxes in patient rooms. In phase 1 of the study, baseline data on policy adherence were captured for 8 patient care units (4 designated as intervention units and 4 designated as control units)...
December 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29221944/living-uterus-donation-and-transplantation-experience-of-interest-and-screening-in-a-single-center-in-the-united-states
#9
Liza Johannesson, Kristin Wallis, E Colin Koon, Gregory J Mckenna, Tiffany Anthony, Sara G Leffingwell, Goran B Klintmalm, Robert T Gunby, Giuliano Testa
BACKGROUND: Little is known about attitudes toward uterus donation and transplantation in society and the interest of the women the treatment is aimed to assist. OBJECTIVE: This study examined the interest of recipients and living donors in our uterus transplantation program; it describes the screening protocol we developed and the results of the screening and reports demographic data and characteristics of screened candidates. STUDY DESIGN: Initial screening and evaluation included physical examinations by a gynecologist and a transplant surgeon; psychological evaluation; imaging (x-ray, computed tomography, ultrasound); blood tests; immunological testing; viral, bacterial, and fungal testing; drug screen; hormonal testing; Pap smear; urinalysis; and electrocardiogram...
December 5, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29220178/equilibrium-between-a-droplet-and-surrounding-vapor-a-discussion-of-finite-size-effects
#10
Andreas Troester, Fabian Schmitz, Peter Virnau, Kurt Binder
In a theoretical description of homogeneous nucleation one frequently assumes an ``equilibrium'' coexistence of a liquid droplet with surrounding vapor of a density exceeding that of a saturated vapor at bulk vapor-liquid two-phase coexistence. Thereby one ignores the caveat that in the thermodynamic limit, for which the vapor would be called supersaturated, such states will at best be metastable with finite lifetime, and thus not be well-defined within equilibrium statistical mechanics. In contrast, in a system of finite volume stable equilibrium coexistence of droplet and supersaturated vapor at constant total density is perfectly possible, and numerical analysis of equilibrium free energies of finite systems allows to obtain physically relevant results...
December 8, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29219093/feasibility-of-implementing-a-cellphone-based-reminder-recall-strategy-to-improve-childhood-routine-immunization-in-a-low-resource-setting-a-descriptive-report
#11
Victoria Bolanle Brown, O Abimbola Oluwatosin
BACKGROUND: Reminder/recall systems are effective ways to improve immunization rates, but their feasibility in primary health care (PHC) settings in Nigeria has not been adequately evaluated. In this study we describe the acceptability and adaptability of immunization reminder/recall system in an urban setting in southwest Nigeria. METHODS: This is a descriptive report of a cluster randomized controlled trial. Four local government areas (LGAs) were randomly assigned into a cellphone reminder/recall intervention group or a usual care control group...
December 4, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29218822/european-academy-of-neurology-european-stroke-organisation-consensus-statement-and-practical-guidance-for-pre-hospital-management-of-stroke
#12
A Kobayashi, A Czlonkowska, G A Ford, A C Fonseca, G J Luijckx, J Korv, N Pérez de la Ossa, C Price, D Russell, A Tsiskaridze, M Messmer-Wullen, J De Keyser
Reduction of delay between onset and hospital arrival and adequate pre-hospital care of persons with acute stroke are important for improving chances of a favorable outcome. The objective is to recommend evidence-based practices for the management of patients with suspected stroke in the pre-hospital setting. The GRADE (Grading of Recommendations Assessment, Development and Evaluation) methodology was used to define the key clinical questions. An expert panel then reviewed the literature, established the quality of the evidence, and made recommendations...
December 7, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29218634/walking-the-seven-lines-binuclear-copper-a-in-cytochrome-c-oxidase-and-nitrous-oxide-reductase
#13
REVIEW
Peter M H Kroneck
The enzymes nitrous oxide reductase (N2OR) and cytochrome c oxidase (COX) are constituents of important biological processes. N2OR is the terminal reductase in a respiratory chain converting N2O to N2 in denitrifying bacteria; COX is the terminal oxidase of the aerobic respiratory chain of certain bacteria and eukaryotic organisms transforming O2 to H2O accompanied by proton pumping. Different spectroscopies including magnetic resonance techniques, were applied to show that N2OR has a mixed-valent Cys-bridged [Cu1...
December 7, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29216883/transplant-eligibility-for-patients-with-affective-and-psychotic-disorders-a-review-of-practices-and-a-call-for-justice
#14
Katherine L Cahn-Fuller, Brendan Parent
BACKGROUND: The scarcity of human organs requires the transplant community to make difficult allocation decisions. This process begins at individual medical centers, where transplant teams decide which patients to place on the transplant waiting list. Each transplant center utilizes its own listing criteria to determine if a patient is eligible for transplantation. These criteria have historically considered preexisting affective and psychotic disorders to be relative or absolute contraindications to transplantation...
December 8, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/29216028/progress-toward-global-eradication-of-dracunculiasis-january-2016-june-2017
#15
Donald R Hopkins, Ernesto Ruiz-Tiben, Mark L Eberhard, Sharon L Roy, Adam J Weiss
Dracunculiasis (Guinea worm disease) is caused by Dracunculus medinensis, a parasitic worm. Approximately 1 year after a person acquires infection from contaminated drinking water, the worm emerges through the skin, usually on a lower limb (1). Pain and secondary bacterial infection can cause temporary or permanent disability that disrupts work and schooling. The campaign to eradicate dracunculiasis worldwide began in 1980 at CDC. In 1986, the World Health Assembly called for dracunculiasis elimination,* and the global Guinea Worm Eradication Program, led by the Carter Center and supported by the World Health Organization (WHO), United Nations Children's Fund, CDC, and other partners, began assisting ministries of health in countries with endemic dracunculiasis...
December 8, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29214641/an-app-to-enhance-resident-education-in-otolaryngology
#16
Wayne D Hsueh, John P Bent, Howard S Moskowitz
OBJECTIVE: Technological change is leading to an evolution in medical education. The objective of our study was to assess the impact of a medical knowledge app, called PulseQD, on resident education within our otolaryngology-head and neck surgery department at Montefiore Medical Center, Albert Einstein College of Medicine (Bronx, NY). METHODS: A prospective cohort study was conducted within the Department of Otolaryngology-Head and Neck Surgery from July 2016 to June 2017...
December 7, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29214598/evaluation-of-a-wireless-portable-wearable-multi-parameter-vital-signs-monitor-in-hospitalized-neurological-and-neurosurgical-patients
#17
Robert S Weller, Kristina L Foard, Timothy N Harwood
Unrecognized changes in patients' vital signs can result in preventable deaths in hospitalized patients. Few publications or studies instituting routine patient monitoring have described implementation and the setting of alarm parameters for vital signs. We wanted to determine if continuous multi-parameter patient monitoring can be accomplished with an alarm rate that is acceptable to hospital floor nurses and to compare the rate of patient deterioration events to those observed with routine vital sign monitoring...
December 6, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29211178/a-wave-that-comes-rushing-in-and-dunks-you-representations-and-destinies-of-the-crisis-in-adolescent-users-of-a-capsi
#18
Melissa de Oliveira Pereira, Marilene de Castilho Sá, Lilian Miranda
This article focuses on the inter-subjective aspects involved in the care of psychosocial crises of adolescents, their representations and developments. A qualitative research was developed from a psycho-sociological perspective by constructing life story narratives of adolescents treated at a Psychosocial Care Center for Children and Adolescents (CAPSi). It was based on the theoretical contributions of René Kaës on group and cultural aspects of the crisis, as well as its relation to adolescence. Life narratives, constructed through in-depth interviews with adolescents, close relatives, and CAPSi caretakers depict crisis as a "surprise", as violence and estrangement, an episode that must be forgotten, denied, silenced, and medicalized...
November 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29208996/relativistic-inverse-compton-scattering-of-photons-from-the-early-universe
#19
Siddharth Malu, Abhirup Datta, Sergio Colafrancesco, Paolo Marchegiani, Ravi Subrahmanyan, D Narasimha, Mark H Wieringa
Electrons at relativistic speeds, diffusing in magnetic fields, cause copious emission at radio frequencies in both clusters of galaxies and radio galaxies through non-thermal radiation emission called synchrotron. However, the total power radiated through this mechanism is ill constrained, as the lower limit of the electron energy distribution, or low-energy cutoffs, for radio emission in galaxy clusters and radio galaxies, have not yet been determined. This lower limit, parametrized by the lower limit of the electron momentum - pmin - is critical for estimating the total energetics of non-thermal electrons produced by cluster mergers or injected by radio galaxy jets, which impacts the formation of large-scale structure in the universe, as well as the evolution of local structures inside galaxy clusters...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29205445/analysis-of-the-u-s-patient-referral-network
#20
Chuankai An, A James O'Malley, Daniel N Rockmore, Corey D Stock
In this paper, we analyze the US Patient Referral Network (also called the Shared Patient Network) and various subnetworks for the years 2009 to 2015. In these networks, two physicians are linked if a patient encounters both of them within a specified time interval, according to the data made available by the Centers for Medicare and Medicaid Services. We find power law distributions on most state-level data as well as a core-periphery structure. On a national and state level, we discover a so-called small-world structure as well as a "gravity law" of the type found in some large-scale economic networks...
December 4, 2017: Statistics in Medicine
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