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https://www.readbyqxmd.com/read/28209422/-the-role-of-spirometry-in-encouraging-smoking-cessation-in-general-practice-a-pilot-study-using-lung-age
#1
A Lorenzo, F Noël, M Lorenzo, J Van Den Broucke
INTRODUCTION: Our aim was to investigate whether spirometry, performed in general practitioners' offices would change non-motivated smokers' attitudes toward smoking cessation. METHOD: We performed an interventional, prospective, before-after single-center study, approved by a research ethics committee. We included 74 smokers older than 18years old, who reported no intention to quit smoking, whatever they were visiting general practitioners for. We performed spirometry and gave them their results, FEV1/FVC and lung age together with a comment on it...
February 13, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28207909/the-psychometric-properties-of-the-safety-attitudes-questionnaire-in-out-of-hours-primary-care-services-in-the-netherlands
#2
Marleen Smits, Ellen Keizer, Paul Giesen, Ellen Catharina Tveter Deilkås, Dag Hofoss, Gunnar Tschudi Bondevik
BACKGROUND: The Safety Attitudes Questionnaire (SAQ) is one of the most widely used instruments to assess safety culture among healthcare providers. The ambulatory version of the SAQ (SAQ-AV) can be used in the primary care setting. Our study objective was to examine the underlying factors and psychometric properties of the Dutch translation of the SAQ-AV in out-of-hours primary care services. DESIGN: Cross-sectional observational study using a web-survey. SETTING: Sixteen out-of-hours general practitioner cooperatives and two call centers in the Netherlands...
2017: PloS One
https://www.readbyqxmd.com/read/28202769/project-impact-pilot-report-feasibility-of-implementing-a-hospital-to-home-transition-bundle
#3
Leah A Mallory, Snezana Nena Osorio, B Stephen Prato, Jennifer DiPace, Lisa Schmutter, Paula Soung, Amanda Rogers, William J Woodall, Kayla Burley, Sandra Gage, David Cooperberg
BACKGROUND AND OBJECTIVES: To improve hospital to home transitions, a 4-element pediatric patient-centered transition bundle was developed, including: a transition readiness checklist; predischarge teach-back education; timely and complete written handoff to the primary care provider; and a postdischarge phone call. The objective of this study was to demonstrate the feasibility of bundle implementation and report initial outcomes at 4 pilot sites. Outcome measures included postdischarge caregiver ability to teach-back key home management information and 30-day reuse rates...
February 15, 2017: Pediatrics
https://www.readbyqxmd.com/read/28196486/integrated-care-at-home-reduces-unnecessary-hospitalizations-of-community-dwelling-frail-older-adults-a-prospective-controlled-trial
#4
Laura Di Pollina, Idris Guessous, Véronique Petoud, Christophe Combescure, Bertrand Buchs, Philippe Schaller, Michel Kossovsky, Jean-Michel Gaspoz
BACKGROUND: Care of frail and dependent older adults with multiple chronic conditions is a major challenge for health care systems. The study objective was to test the efficacy of providing integrated care at home to reduce unnecessary hospitalizations, emergency room visits, institutionalization, and mortality in community dwelling frail and dependent older adults. METHODS: A prospective controlled trial was conducted, in real-life clinical practice settings, in a suburban region in Geneva, Switzerland, served by two home visiting nursing service centers...
February 14, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28196282/phosphatidylethanol-peth-detects-moderate-to-heavy-alcohol-use-in-liver-transplant-recipients
#5
Michael Francis Fleming, Matthew J Smith, Erika Oslakovic, Michael R Lucey, Jenny X Vue, Patrice Al-Saden, Josh Levitsky
BACKGROUND: Alcohol dependent liver transplantation (LT) patients who resume alcohol are at risk for a number of alcohol related problems including liver injury and liver failure. Post LT patients are strongly advised to remain abstinent. However, we don't know how well this population complies due to a lack of valid methods (self-report and/or biomarkers) to identify alcohol use. Studies suggest as many as 50% resume alcohol use within 5 years. Phosphatidylethanol (PEth) is a new cell-membrane phospholipid biomarker to identify alcohol use in the past 28 days...
February 14, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28192086/variant-call-concordance-between-two-laboratory-developed-solid-tumor-targeted-genomic-profiling-assays-using-distinct-workflows-and-sequencing-instruments
#6
Ken J Hampel, Francine B de Abreu, Nikoletta Sidiropoulos, Jason D Peterson, Gregory J Tsongalis
Targeted genomic profiling (TGP) using massively parallel DNA sequencing is becoming the standard methodology in clinical laboratories for detecting somatic variants in solid tumors. The variety of methodologies and sequencing platforms in the marketplace for TGP has resulted in a variety of clinical TGP laboratory developed tests (LDT). The variability of LDTs is a challenge for test-to-test and laboratory-to-laboratory reliability. At the University of Vermont Medical Center (UVMMC), we validated a TGP assay for solid tumors which utilizes DNA hybridization capture and complete exon and selected intron sequencing of 29 clinically actionable genes...
February 10, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28190626/interrupting-pathways-to-sepsis-effectiveness-of-an-intervention-to-reduce-delays-in-timely-care-for-sick-children-in-rural-bangladesh
#7
Frances E Aboud, Ehsanur Rahman, Rosemin Kassam, Jasmin Khan, Nabeel Ashraf Ali, Fahmida Taleb
RATIONALE: The time it takes for a child with suspected sepsis to receive care is critical. OBJECTIVE: We evaluated care-seeking practices for sick children under 5 years in rural Bangladesh, following interpersonal communication to inform households of newly introduced supports for quality care. Based on the Delays Framework, we assessed length and source of care-seeking delays, use of formal providers, and autonomous decision-making among mothers. METHOD: Using two cross-sectional rounds before and after the 3-year intervention (August 2012 and August 2015), we surveyed 400 mothers of recently sick children in 26 randomly sampled villages from 2 intervention and 2 control subdistricts, using structured questions about delays...
February 1, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28190410/the-effect-of-older-age-on-ems-use-for-transportation-to-an-emergency-department
#8
Courtney M C Jones, Erin B Wasserman, Timmy Li, Ashley Amidon, Marissa Abbott, Manish N Shah
: Introduction Previous studies have found that older adults are more likely to use Emergency Medical Services (EMS) than younger adults, but the reasons for this remain understudied. Hypothesis/Problem This study aimed to determine if older age is associated with using EMS for transportation to an emergency department (ED) after controlling for confounding variables. METHODS: A cross-sectional survey study was conducted at a large academic medical center. Data on previous medical history, chief complaint, self-perceived illness severity, demographic information, and mode of arrival to the ED were collected on all subjects...
February 13, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28188555/curvature-effects-on-the-velocity-profile-in-turbulent-pipe-flow
#9
Siegfried Grossmann, Detlef Lohse
Prandtl and von Kármán have developed the famous log-law for the mean velocity profile for turbulent flow over a plate. The log-law has also been applied to turbulent pipe flow, though the wall surface is curved (in span-wise direction) and has finite diameter. Here we discuss the theoretical framework, based on the Navier-Stokes equations, with which one can describe curvature effects and also the well-known finite-size effects in the turbulent mean-velocity profile. When comparing with experimental data we confirm that the turbulent eddy viscosity must contain both curvature and finite-size contributions and that the usual ansatz for the turbulent eddy viscosity as being linear in the wall distance is insufficient, both for small and large wall distances...
February 2017: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/28188268/design-and-rationale-of-a-randomized-trial-of-a-care-transition-strategy-in-patients-with-acute-heart-failure-discharged-from-the-emergency-department-guided-hf-get-with-the-guidelines-in-emergency-department-patients-with-heart-failure
#10
Gregory J Fermann, Phillip D Levy, Peter Pang, Javed Butler, S Imran Ayaz, Douglas Char, Patrick Dunn, Cathy A Jenkins, Christy Kampe, Yosef Khan, Vijaya A Kumar, JoAnn Lindenfeld, Dandan Liu, Karen Miller, W Frank Peacock, Samaa Rizk, Chad Robichaux, Russell L Rothman, Jon Schrock, Adam Singer, Sarah A Sterling, Alan B Storrow, Cheryl Walsh, John Wilburn, Sean P Collins
: GUIDED-HF (Get With the Guidelines in Emergency Department Patients With Heart Failure) is a multicenter randomized trial of a patient-centered transitional care intervention in patients with acute heart failure (AHF) who are discharged either directly from the emergency department (ED) or after a brief period of ED-based observation. To optimize care and reduce ED and hospital revisits, there has been significant emphasis on improving transitions at the time of hospital discharge for patients with HF...
February 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28188000/effectiveness-of-a-management-program-for-outpatient-clinic-or-remote-titration-of-beta-blockers-in-crt-patients-the-restore-study
#11
Antonio D'Onofrio, Pietro Palmisano, Antonio Rapacciuolo, Ernesto Ammendola, Leonardo Calò, Antonio Ruocco, Valter Bianchi, Fabio Maresca, Giuseppe Del Giorno, Annamaria Martino, Ciro Mauro, Monica Campari, Sergio Valsecchi, Michele Accogli
BACKGROUND: Many patients fail to receive β-blockers before cardiac resynchronization therapy defibrillator (CRT-D) implantation, or receive them at a suboptimal dose, and require optimization after implantation. We assessed the effectiveness of a structured program for β-blocker titration in CRT-D patients followed up by means of conventional in-clinic visits or remote monitoring. METHODS AND RESULTS: 130 patients undergoing CRT implantation and treated according to the standard practice of the centers were included as a control group...
February 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28187281/how-much-longer-will-we-put-up-with-100-000-cancer-drugs
#12
Paul Workman, Giulio F Draetta, Jan H M Schellens, René Bernards
The spiraling cost of new drugs mandates a fundamentally different approach to keep lifesaving therapies affordable for cancer patients. We call here for the formation of new relationships between academic drug discovery centers and commercial partners, which can accelerate the development of truly transformative drugs at sustainable prices.
February 9, 2017: Cell
https://www.readbyqxmd.com/read/28186380/new-modalities-for-challenging-targets-in-drug-discovery
#13
Herbert Waldmann, Eric Valeur, Stéphanie M Guéret, Hélène Adihou, Ranganath Gopalakrishnan, Malin Lemurell, Tom N Grossmann, Alleyn T Plowright
An ever increasing understanding of biological systems is providing a range of exciting novel biological targets whose modulation may enable novel therapeutic options in many diseases. These targets include protein-protein and protein-nucleic acid interactions, which are, however, often refractory to classical small molecule approaches. Other types of molecules, or modalities, are therefore required to address these targets, which has led several academic research groups and pharmaceutical companies to increasingly use the concept of so-called 'New Modalities'...
February 10, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28185041/variety-in-excitation-energy-transfer-processes-from-phycobilisomes-to-photosystems-i-and-ii
#14
Yoshifumi Ueno, Shimpei Aikawa, Kyosuke Niwa, Tomoko Abe, Akio Murakami, Akihiko Kondo, Seiji Akimoto
The light-harvesting antennas of oxygenic photosynthetic organisms capture light energy and transfer it to the reaction centers of their photosystems. The light-harvesting antennas of cyanobacteria and red algae, called phycobilisomes (PBSs), supply light energy to both photosystem I (PSI) and photosystem II (PSII). However, the excitation energy transfer processes from PBS to PSI and PSII are not understood in detail. In the present study, the energy transfer processes from PBS to PSs in various cyanobacteria and red algae were examined in vivo by selectively exciting their PSs or PBSs, and measuring the resulting picosecond to nanosecond time-resolved fluorescences...
February 9, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28183354/protocol-for-the-analysis-of-a-natural-experiment-on-the-impact-of-the-affordable-care-act-on-diabetes-care-in-community-health-centers
#15
Nathalie Huguet, Heather Angier, Miguel Marino, K John McConnell, Megan J Hoopes, Jean P O'Malley, Lewis A Raynor, Sonja Likumahuwa-Ackman, Heather Holderness, Jennifer E DeVoe
BACKGROUND: It is hypothesized that Affordable Care Act (ACA) Medicaid expansions could substantially improve access to health insurance and healthcare services for patients at risk for diabetes mellitus (DM), with pre-DM, or already diagnosed with DM. The ACA called for every state to expand Medicaid coverage by 2014. In a 2012 legal challenge, the US Supreme Court ruled that states were not required to implement Medicaid expansions. This 'natural experiment' presents a unique opportunity to learn whether and to what extent Medicaid expansion can affect healthcare access and services for patients with DM risk, pre-DM, or DM...
February 10, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28182515/acute-health-effects-after-the-elk-river-chemical-spill-west-virginia-january-2014
#16
Erica D Thomasson, Elizabeth Scharman, Ethan Fechter-Leggett, Danae Bixler, Sheri'f Ibrahim, Mary Anne Duncan, Joy Hsu, Melissa Scott, Suzanne Wilson, Loretta Haddy, Anthony Pizon, Sherry Burrer, Amy Wolkin, Lauren Lewis
OBJECTIVES: On January 9, 2014, approximately 10 000 gallons of a mixture of 4-methylcyclohexanemethanol and propylene glycol phenyl ether spilled into West Virginia's Elk River, contaminating the potable water supply of about 300 000 West Virginia residents. This study sought to describe acute health effects after the chemical spill. METHODS: We conducted a descriptive analysis using 3 complementary data sources: (1) medical records of patients who visited an emergency department during January 9-23, 2014, with illness potentially related to the spill; (2) West Virginia Poison Center caller records coded as "contaminated water" during January 9-23, 2014; and (3) answers to household surveys about health effects from a Community Assessment for Public Health Emergency Response (CASPER) questionnaire administered 3 months after the spill...
January 1, 2017: Public Health Reports
https://www.readbyqxmd.com/read/28182131/getting-patients-in-the-door-medical-appointment-reminder-preferences
#17
Trisha M Crutchfield, Christine E Kistler
PURPOSE: Between 23% and 34% of outpatient appointments are missed annually. Patients who frequently miss medical appointments have poorer health outcomes and are less likely to use preventive health care services. Missed appointments result in unnecessary costs and organizational inefficiencies. Appointment reminders may help reduce missed appointments; particular types may be more effective than other types. We used a survey with a discrete choice experiment (DCE) to learn why individuals miss appointments and to assess appointment reminder preferences...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28179981/deep-assessment-of-genomic-diversity-in-cassava-for-herbicide-tolerance-and-starch-biosynthesis
#18
Jorge Duitama, Lina Kafuri, Daniel Tello, Ana María Leiva, Bernhard Hofinger, Sneha Datta, Zaida Lentini, Ericson Aranzales, Bradley Till, Hernán Ceballos
Cassava is one of the most important food security crops in tropical countries, and a competitive resource for the starch, food, feed and ethanol industries. However, genomics research in this crop is much less developed compared to other economically important crops such as rice or maize. The International Center for Tropical Agriculture (CIAT) maintains the largest cassava germplasm collection in the world. Unfortunately, the genetic potential of this diversity for breeding programs remains underexploited due to the difficulties in phenotypic screening and lack of deep genomic information about the different accessions...
2017: Computational and Structural Biotechnology Journal
https://www.readbyqxmd.com/read/28178913/training-us-health-care-professionals-on-human-trafficking-where-do-we-go-from-here
#19
Clydette Powell, Kirsten Dickins, Hanni Stoklosa
: Some 21 million adults and children are labor-trafficked or sex-trafficked through force, fraud, or coercion. In recognition of the interface between trafficking victims and the healthcare setting, over the last 10 years there has been a notable increase in training of health care professionals (HCPs) on human trafficking (HT) and its health implications. Many organizations have developed curricula and offered training in various clinical settings. However, methods and content of this education on trafficking vary widely, and there is little evaluation of the impact of the training...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28177958/feedback-for-learners-in-medical-education-what-is-known-a-scoping-review
#20
Robert Bing-You, Victoria Hayes, Kalli Varaklis, Robert Trowbridge, Heather Kemp, Dina McKelvy
PURPOSE: To conduct a scoping review of the literature on feedback for learners in medical education. METHOD: In 2015-2016, the authors searched the Ovid MEDLINE, ERIC, CINAHL, ProQuest Dissertations and Theses Global, Web of Science, and Scopus databases and seven medical education journals (via OvidSP) for articles published January 1980-December 2015. Two reviewers screened articles for eligibility with inclusion criteria. All authors extracted key data and analyzed data descriptively...
February 7, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
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