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Use of calcium excretion

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https://www.readbyqxmd.com/read/27889417/dietary-zinc-and-incident-calcium-kidney-stones-in-adolescence
#1
Gregory E Tasian, Michelle E Ross, Lihai Song, Robert W Grundmeier, James Massey, Michelle R Denburg, Lawrence Copelovitch, Steven Warner, Thomas Chi, David W Killilea, Marshall L Stoller, Susan L Furth
PURPOSE: To determine the association between dietary zinc intake and incident calcium kidney stones and examine the relationship between dietary zinc intake and urinary zinc excretion among adolescents. MATERIAL AND METHODS: This study was a nested case-control study conducted within a large pediatric healthcare system. Three 24-hour dietary recalls and spot urine chemistries were obtained for 30 participants aged 12-18 years with a first idiopathic calcium-based kidney stone and 30 healthy controls, matched on age, sex, race, and month of enrollment...
November 23, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27862274/risk-of-fracture-in-primary-aldosteronism-a-population-based-cohort-study
#2
Vin-Cent Wu, Chia-Hui Chang, Cheng-Yi Wang, Yen-Hung Lin, Tze-Wah Kao, Po-Chih Lin, Tzong-Shinn Chu, Yuan-Shian Chang, Likwang Chen, Kwan-Dun Wu, Shih-Chieh Jeff Chueh
Primary aldosteronism (PA) is associated with increased urinary calcium excretion and osteoporosis prevalence. We studied the long-term effect of hyperaldosterone on fracture risk and possible risk mitigation via treatments, by comparing PA patients and their essential hypertension (EH) counterparts extracted by propensity score match. We used a longitudinal population database from the Taiwan National Health Insurance, and used a validated algorithm to identify PA patients diagnosed in 1997-2010. Our sample included 2533 PA patients, including 921 patients with aldosterone-producing adenoma (APA)...
November 10, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27818277/comparison-of-the-effects-of-novel-vitamin-d-receptor-analog-vs-105-and-paricalcitol-on-chronic-kidney-disease-mineral-bone-disorder-in-an-experimental-model-of-chronic-kidney-disease
#3
Hideki Fujii, Yuriko Yonekura, Kentaro Nakai, Keiji Kono, Shunsuke Goto, Shinichi Nishi
When using vitamin D, the most important clinical problems are hypercalcemia, hyperphosphatemia, and vascular calcification. VS-105 is a novel vitamin D receptor (VDR) analog. In the present study, we compared the effects of VS-105 and paricalcitol on chronic kidney disease-mineral bone disorder (CKD-MBD) in a CKD rat model. We used male Sprague-Dawley (SD) rats and performed 5/6 nephrectomy at 8-9 weeks. At 10 weeks, the rats were classified into five groups and administered vehicle, low-dose paricalcitol (LP, 0...
November 3, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27815929/challenges-in-the-management-of-hypertension-in-older-populations
#4
Lisa Pont, Tariq Alhawassi
The prevalence of hypertension increases with age making it a significant health concern for older persons. Aging involves a range of physiological changes such as increases in arterial stiffness, widening pulse pressure, changes in renin and aldosterone levels, decreases in renal salt excretion, declining in renal function, changes in the autonomic nervous system sensitivity and function and changes to endothelial function all of which may not only affect blood pressure but may also affect individual response to pharmacotherapy used to manage hypertension and prevent end organ damage and other complications associated with poor blood pressure control...
November 5, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27813709/serum-1-25-dihydroxyvitamin-d-as-a-biomarker-of-the-absence-of-hypercalciuria-in-postsurgical-hypoparathyroidism
#5
Luis García-Pascual, María José Barahona, Verónica Perea, Rafael Simó
CONTEXT: Hypercalciuria is an adverse event of postsurgical hypoparathyroidism treatment which can lead to renal complications. The collection of 24-hour urine to detect hypercalciuria is often considered unreliable. OBJECTIVE: To find useful predictive biomarkers of hypercalciuria in patients with permanent postsurgical hypoparathyroidism under treatment with oral calcium and calcitriol supplements. DESIGN: Prospective cross-sectional study...
November 4, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27803672/autosomal-dominant-hypocalcemia-hypoparathyroidism-types-1-and-2
#6
REVIEW
Kelly L Roszko, Ruiye D Bi, Michael Mannstadt
Extracellular calcium is essential for life and its concentration in the blood is maintained within a narrow range. This is achieved by a feedback loop that receives input from the calcium-sensing receptor (CASR), expressed on the surface of parathyroid cells. In response to low ionized calcium, the parathyroids increase secretion of parathyroid hormone (PTH) which increases serum calcium. The CASR is also highly expressed in the kidneys, where it regulates the reabsorption of calcium from the primary filtrate...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27795978/smoking-habits-and-parathyroid-hormone-concentrations-in-young-adults-the-cardia-study
#7
Akira Fujiyoshi, Lynda E Polgreen, Myron D Gross, Jared P Reis, Stephen Sidney, David R Jacobs
Conflicting results have been reported concerning a relationship between smoking and serum PTH. Our study objective was to examine whether smoking was associated with serum PTH independent of correlates of PTH among young adults, and explore potential mechanisms. This was a cross-sectional study of healthy individuals, 24-36 years old, examined during 1992 through 1993 in California, USA (a subset of Coronary Artery Risk Development in Young Adults study). Linear regression was used to obtain adjusted means of PTH according to smoking habit (current, former, never)...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/27785747/is-chronic-alkali-therapy-in-orthotopic-ileal-neobladders-necessary-a-prospective-controlled-study
#8
Osama Mahmoud, Ahmed El-Assmy, Mohamed Kamal, Albeer Ashamallah, Hassan Abol-Enein
PURPOSE: To evaluate the necessity of chronic alkali therapy in non-complicated orthotopic ileal neobladders with normal renal function. MATERIALS AND METHODS: This is a prospective study that included 200 male patients who underwent radical cystectomy and ileal W neobladder for invasive bladder carcinoma between January 1993 and December 2013. The studied patients included 100 consecutive patients who were maintained on regular alkali therapy since surgery and 100 consecutive patients who stopped the use of alkali treatment after initial 3 months postoperative with minimum postoperative observation time of 1 year...
October 26, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27753966/os-10-05-association-of-aortic-pulse-wave-velocity-with-mineral-metabolism-factors-and-blood-pressure-in-untreated-chinese-patients
#9
Yi-Bang Cheng, Li-Hua Li, Qian-Hui Guo, Chang-Sheng Sheng, Qi-Fang Huang, Fei-Ka Li, Dong-Yan Zhang, Ji-Guang Wang, Yan Li
OBJECTIVE: Disorders of mineral metabolism predicted incidence of cardiovascular events in various clinical settings, possibly because that arterial stiffness mediate this pathway in part. We investigated the interrelationship between mineral metabolism factors and carotid-femoral PWV, and compared the effect sizes of blood pressure (BP) and mineral factors with carotid-femoral PWV in untreated Chinese. DESIGN AND METHOD: Consecutive untreated outpatients referred for ambulatory BP monitoring were recruited...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27744602/zinc-fractional-absorption-from-a-representative-diet-in-young-chinese-men-and-women-of-the-shandong-rural-region
#10
Cuiping Wang, Xinying Lin, Dongmei Guo, Lili Ding, Haifeng Guo, Guifa Xu, Xi Cui, Xia Wang
The objective of this study was to investigate the zinc fractional absorption of young Chinese men and women from the Shandong rural region under the routine dietary pattern by stable isotope technique. Ten men and 10 women, aged 20 to 35 years, and with a representative diet during the experiment were recruited from the Shandong rural region. Stable (67)Zn was used as a tracer to label ZnCl2, and Yb was used to monitor the excretion of (67)Zn in urine and feces. All volunteers were given rice containing 4...
October 15, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27733975/might-e-cadherin-promoter-polymorphisms-of-rs16260-and-rs5030625-associate-with-the-risk-of-nephrolithiasis
#11
Cigdem Donmez, Ece Konac, Batuhan T Aydogan, Cenk Y Bilen
PURPOSE: To study whether -160 C > A (rs16260) and -347 G > GA (rs5030625) single nucleotide polymorphisms of the regulatory region (rSNPs) of CDH1 gene modulate the risk of nephrolithiasis. METHODS: Genomic DNA of 101 patients with calcium oxalate nephrolithiasis and 114 healthy controls were screened for both polymorphisms, using polymerase chain reaction-restriction fragments length polymorphism method (PCR-RLFP). Haplotype frequencies were also analyzed...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27730307/calcium-oxalate-urolithiasis-in-children-urinary-promoters-inhibitors-and-role-of-their-ratios
#12
Daniel Turudic, Danica Batinic, Anja Tea Golubic, Mila Lovric, Danko Milosevic
: Diagnostic criteria for determination of inclination towards idiopathic calcium oxalate (CaOx) urolithiasis based on biochemical urine parameters are not sufficiently well defined in children. The aim of this study was to determine the risk of CaOx urolithiasis in children from concentrations of calcium, oxalate, citrate, and glycosaminoglycans in urine and their ratios, all standardized in respect to creatinine. We collected and analyzed 24-h urine samples of children with CaOx urolithiasis (n = 61) and compared with urine samples of matched control group of healthy children (n = 25)...
October 11, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27679518/effect-of-patiromer-on-urinary-ion-excretion-in-healthy-adults
#13
David A Bushinsky, David M Spiegel, Coleman Gross, Wade W Benton, Jeanene Fogli, Kathleen M Hill Gallant, Charles Du Mond, Geoffrey A Block, Matthew R Weir, Bertram Pitt
BACKGROUND AND OBJECTIVES: Patiromer is a nonabsorbed potassium-binding polymer that uses calcium as the counterexchange ion. The calcium released with potassium binding has the potential to be absorbed or bind phosphate. Because binding is not specific for potassium, patiromer can bind other cations. Here, we evaluate the effect of patiromer on urine ion excretion in healthy adults, which reflects gastrointestinal ion absorption. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We analyzed the effect of patiromer on urine potassium, sodium, magnesium, calcium, and phosphate in two studies...
September 27, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27670150/in-vitro-investigation-of-intestinal-transport-mechanism-of-silicon-supplied-as-orthosilicic-acid-vanillin-complex
#14
Thérèse Sergent, Karine Croizet, Yves-Jacques Schneider
SCOPE: Silicon (Si) is one of the most abundant trace elements in the body. Although pharmacokinetics data described its absorption from the diet and its body excretion, the mechanisms involved in the uptake and transport of Si across the gut wall have not been established. METHODS AND RESULTS: Caco-2 cells were used as a well-accepted in vitro model of the human intestinal epithelium to investigate the transport, across the intestinal barrier in both the absorption and excretion directions, of Si supplied as orthosilicic acid stabilized by vanillin complex (OSA-VC)...
September 27, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27663026/response-of-germ-free-mice-to-colonization-with-o-formigenes-and-altered-schaedler-flora
#15
Xingsheng Li, Melissa L Ellis, Alexander E Dowell, Ranjit Kumar, Casey D Morrow, Trenton R Schoeb, John Knight
: Colonization with Oxalobacter formigenes may reduce the risk of calcium oxalate kidney stone disease. To improve our limited understanding of host/O.formigenes and microbe/O.formigenes interactions, germ-free or altered Schaedler flora (ASF) mice were colonized with O.formigenes Germ-free mice were stably colonized with O.formigenes suggesting O.formigenes does not require other organisms to sustain its survival. Examination of intestinal material indicated no viable O.formigenes in the small intestine, ∼4 × 10(6) O...
September 23, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27643363/os-10-05-association-of-aortic-pulse-wave-velocity-with-mineral-metabolism-factors-and-blood-pressure-in-untreated-chinese-patients
#16
Yi-Bang Cheng, Li-Hua Li, Qian-Hui Guo, Chang-Sheng Sheng, Qi-Fang Huang, Fei-Ka Li, Dong-Yan Zhang, Ji-Guang Wang, Yan Li
OBJECTIVE: Disorders of mineral metabolism predicted incidence of cardiovascular events in various clinical settings, possibly because that arterial stiffness mediate this pathway in part. We investigated the interrelationship between mineral metabolism factors and carotid-femoral PWV, and compared the effect sizes of blood pressure (BP) and mineral factors with carotid-femoral PWV in untreated Chinese. DESIGN AND METHOD: Consecutive untreated outpatients referred for ambulatory BP monitoring were recruited...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27561347/-the-efficacy-and-safety-of-bisphosphonate-for-patients-with-kidney-disease
#17
Rikako Hiramatsu, Yoshifumi Ubara
Bisphoshonate is largely used for treatment of osteoporosis in general population. The gastrointestinal absorption is poor and it can be excreted via only kidney. Therefore, CKD patients can accumulate a higher dose of bisphosphonate in their body. Although the primary action of bisphosphonate is the inhibition of bone resorption, it secondary suppresses bone formation, which can often lead to adynamic bone disease in patients with CKD. In CKD patients who still have normal parathyroid hormone, calcium, and phosphate levels, randomized trials showed the similar effects as in non-CKD patients;however, in patients with CKD stage 4 and dialysis patients, data are very limited and the benefits and safety has remained unclear...
September 2016: Clinical Calcium
https://www.readbyqxmd.com/read/27561204/autosomal-dominant-hypocalcemia-due-to-a-truncation-in-the-c-tail-of-the-calcium-sensing-receptor
#18
Katia Maruca, Ilaria Brambilla, Alessandra Mingione, Lorenzo Bassi, Silvia Capelli, Caterina Brasacchio, Laura Soldati, Mariangela Cisternino, Stefano Mora
Autosomal Dominant Hypocalcemia (ADH) is an endocrine disorder due to activating mutations of the calcium-sensing receptor (CASR) gene. We report on a young boy who presented low serum calcium with hypercalciuria, hyperphosphatemia and low serum concentration of parathyroid hormone, not accompanied by classic clinical signs of hypocalcemia. Treatment with calcitriol and calcium did not normalize serum calcium and renal calcium excretion. The use of thiazide diuretics slightly reduced calciuria. Despite high calcium excretion, no signs of nephrocalcinosis were detected...
August 22, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27545632/-the-effects-of-cinacalcet-in-renal-stone-formers-with-primary-hyperparathyroidism
#19
Corrado Vitale, Francesca Bermond, Amelia Rodofili, Giorgio Soragna, Cristina Marcuccio, Alberto Tricerri, Martino Marangella
Primary hyperparathyroidism (PHPT) may favor nephrolithiasis mainly through an increase in calcium and phosphate urinary excretion. Cinacalcet exhibits good efficacy to control hypercalcemia in PHPT, but it is not so far known whether it might be a useful tool to prevent stone recurrences. Of 67 patients with PHPT and recurrent nephrolithiasis, 55 underwent parathyroidectomy (PTX) and 12, not eligible to PTX, were prescribed Cinacalcet. All the patients were evaluated for mineral metabolism, including estimation of state of saturation for calcium oxalate (CaOx) and brushite (bsh), both at baseline and after either PTX or Cinacalcet...
July 2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/27540249/use-of-teriparatide-in-a-four-year-old-patient-with-autosomal-dominant-hypocalcaemia
#20
Andy Fox, Rodney Gilbert
AIM: We report the effective use of the synthetic parathyroid hormone (PTH) teriparatide to treat a 4 year old boy with autosomal dominant hypocalcaemia. BACKGROUND: Autosomal Dominant hypocalcaemia is characterised by hypocalcaemia with a lack of parathyroid hormone (PTH) response and inappropriately high urinary calcium excretion. It is caused by gain-of-function mutations in the extracellular calcium sensing receptor which then "over-reads" the extracellular fluid concentration of calcium resulting in suppression of PTH secretion...
September 2016: Archives of Disease in Childhood
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