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Inflammatory arthritis

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https://www.readbyqxmd.com/read/29793098/evaluation-of-analgesic-and-anti-inflammatory-activities-of-rubia-cordifolia-l-by-spectrum-effect-relationships
#1
REVIEW
Cai-Hong Shen, Cui-Ting Liu, Xiao-Juan Song, Wei-Ya Zeng, Xiao-Ying Lu, Zuo-Liang Zheng, Jie-Pan, Ruo-Ting Zhan, Ping-Yan
The objective of the current work was to evaluate the spectrum-effect relationships between high-performance liquid chromatography fingerprints and analgesic and anti-inflammatory effects of Rubia cordifolia L. extract (RCE), and to identify active components of RCE. Chemical fingerprints of ten batches of RC from various sources were obtained by HPLC, and similarity and hierarchical clustering analyses were carried out. Pharmacodynamic assays were performed in adjuvant-induced arthritis rat model to assess the analgesic and anti-inflammatory properties of RCE...
May 17, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29792084/lethal-disseminated-tuberculosis-in-patients-under-biological-treatment-two-clinical-cases-and-a-short-review
#2
Elena Dantes, Doina Ecaterina Tofolean, Ariadna Petronela Fildan, Liviu Craciun, Elena Dumea, Ioan Tiberiu Tofolean, Laura Mazilu
Tumour necrosis factor (TNF)-α inhibitors are highly used in Romania for the treatment of autoimmune disorders, such as rheumatoid arthritis (RA), psoriasis, inflammatory bowel diseases, and ankylosing spondylitis. Biological therapy using TNF-α inhibitors is very effective but is associated with an increased risk of opportunistic infections, including active tuberculosis. Here, two cases are presented of patients with RA and psoriasis under biological therapy who developed very aggressive forms of disseminated tuberculosis, with a rapid progression to death...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29791754/atp-triggers-a-robust-intracellular-ca-2-mediated-signalling-pathway-in-human-synovial-fibroblasts
#3
Kondo C, R B Clark, T Y Kim, Belke D, Banderali U, R T Szerencsei, A H Jalloul, P P M Schnetkamp, Spitzer Kw, Giles Wr
NEW FINDINGS: What is the central question of this study? In human articular joints, the synovial fibroblast HSF cell population has essential functions including secretion of lubricants. We address some remaining questions concerning activation-secretion coupling by characterizing the main [Ca2+ ]i signalling pathways activated by ATP. What is the main finding and its importance? In HSF ATP acts through a linked G-protein (Gq ) and phospholipase C signalling mechanisms to produce IP-3 which markedly enhances release of Ca2+ from the endoplasmic reticulum...
May 23, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29791652/inflammatory-myopathy-in-the-context-of-an-unusual-overlapping-laminopathy
#4
Cristina Guillín-Amarelle, Sofía Sánchez-Iglesias, Antonio Mera, Elena Pintos, Ana Castro-Pais, Leticia Rodríguez-Cañete, Julio Pardo, Felipe F Casanueva, David Araújo-Vilar
Laminopathies are genetic disorders associated with alterations in nuclear envelope proteins, known as lamins. The LMNA gene encodes lamins A and C, and LMNA mutations have been linked to diseases involving fat (type 2 familial partial lipodystrophy [FPLD2]), muscle (type 2 Emery-Dreifuss muscular dystrophy [EDMD2], type 1B limb-girdle muscular dystrophy [LGMD1B], and dilated cardiomyopathy), nerves (type 2B1 Charcot-Marie-Tooth disease), and premature aging syndromes. Moreover, overlapping syndromes have been reported...
May 17, 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29791314/analgesic-anti-inflammatory-and-anti-arthritic-properties-of-aqueous-and-methanolic-stem-bark-extracts-from-nauclea-pobeguinii-rubiacee-in-rats
#5
Mbiantcha Marius, Tsafack Eric Gonzal, Ateufack Gilbert, Nana Yousseu William, Bomba Tatsinkou Francis Désiré, Djuichou Nguemnang Stephanie Flore, Mbankou Ngassam Sorelle, Wego Kamgaing Marius Tresor
Background Nauclea pobeguinii is a plant species found in the centre region of Cameroon. The stem bark of this plant is traditionally used to ease pain and cure inflammation. Method This study was undertaken to evaluate the effects of doses 150 and 300 mg/kg of the aqueous and methanolic stem bark extracts from Nauclea pobeguinii on acute pain, acute and chronic inflammation induced by formalin and arthritis induced by zymosan A in rats. Oxidative stress parameters such as catalase, malondialdehyde and nitric oxide were measured in rats subjected to chronic inflammation...
May 23, 2018: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29790372/folate-receptor-targeted-mixed-polysialic-acid-micelles-for-combating-rheumatoid-arthritis-in-vitro-and-in-vivo-evaluation
#6
Nan Zhang, Chunyu Xu, Na Li, Shasha Zhang, Lingling Fu, Xiao Chu, Haiying Hua, Xianghui Zeng, Yongxing Zhao
OBJECTIVE: Rheumatoid arthritis (RA) is associated with chronic inflammation. The suppression of inflammation is key to the treatment of RA. Glucocorticoids (GCs) are classical anti-inflammatory drugs with several disadvantages such as poor water solubility and low specificity in the body. These disadvantages are the reasons for the quick elimination and side effects of GCs in vivo. Micelles are ideal carriers for GCs delivery to inflamed synovium. We set out to improve the targeting and pharmacokinetic profiles of GCs by preparing a targeting micelle system...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29790305/lyme-disease-associated-igg4-autoantibodies-correlate-with-synovial-pathology-in-antibiotic-refractory-lyme-arthritis
#7
Katherine B Sulka, Klemen Strle, Jameson T Crowley, Robert B Lochhead, Robert Anthony, Allen C Steere
OBJECTIVE: To determine whether IgG subclasses of B. burgdorferi antibodies differ from those of 3 Lyme disease (LD)-associated autoantibodies. METHODS: The IgG antibody subclasses were determined by ELISA in serum samples from 215 patients representative of each of the 3 stages of Lyme disease. Antibody and cytokine profiles were measured in matched serum and synovial fluid (SF) samples from Lyme arthritis patients. Synovial tissue from patients with antibiotic-refractory arthritis was examined for histologic features, IgG subclasses of plasma cells, and mRNA subclass expression...
May 23, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29790294/jak-stat-blockade-alters-synovial-bioenergetics-mitochondrial-function-and-pro-inflammatory-mediators-in-rheumatoid-arthritis
#8
Trudy McGarry, Carl Orr, Sarah Wade, Monika Biniecka, Siobhan Wade, Lorna Gallagher, Candice Low, Douglas J Veale, Ursula Fearon
OBJECTIVE: To examine the effect of tofacitinib on metabolic activity, mitochondrial function and pro-inflammatory mechanisms in Rheumatoid Arthritis. METHODS: Ex-vivo RA synovial explants and primary RA synovial fibroblasts (RAFLS) were cultured with tofacitinib (1μM). RAFLS bioenergetics was assessed using the XF24-Flux-analyser, and key metabolic genes by real-time PCR. Mitochondrial function was assessed using specific cell fluorescent probes and by mitochondrial gene arrays...
May 23, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29789121/aire-is-not-essential-for-regulating-neuroinflammatory-disease-in-mice-transgenic-for-human-autoimmune-diseases-associated-mhc-class-ii-genes-hla-dr2b-and-hla-dr4
#9
Saisha A Nalawade, Niannian Ji, Itay Raphael, Andrew Pratt, Ellen Kraig, Thomas G Forsthuber
The human autoimmune disease-associated HLA alleles HLA-DR2b (DRB1*1501) and HLA-DR4 (DRB1*0401) are strongly linked to increased susceptibility for multiple sclerosis (MS) and rheumatoid arthritis (RA), respectively. The underlying mechanisms are not fully understood, but these MHC alleles may shape the repertoire of pathogenic T cells via central tolerance. The transcription factor autoimmune regulator (AIRE) promotes central T cell tolerance via ectopic expression of tissue-specific antigens (TSAs). Aire deficiency in humans causes autoimmune polyendocrinopathy syndrome type 1 (APS1), and Aire knockout mice (Aire-/- ) develop spontaneous autoimmune pathology characterized by multi-organ lymphocytic infiltrates...
May 14, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29789008/pharmacological-effects-of-n-2-2-2-2-6-dichlorophenyl-amino-phenyl-acetyl-oxy-ethyl-hyaluronamide-diclofenac-etalhyaluronate-si-613-a-novel-sodium-hyaluronate-derivative-chemically-linked-with-diclofenac
#10
Keiji Yoshioka, Tomochika Kisukeda, Ryoji Zuinen, Yosuke Yasuda, Kenji Miyamoto
BACKGROUND: Osteoarthritis (OA) is the most common joint disorder worldwide and one of the leading causes of disability in the elderly. We have investigated the novel sodium hyaluronate derivative chemically linked with diclofenac (DF), diclofenac etalhyaluronate (SI-613), which is a potentially safer and more effective treatment for OA knee pain. In this study, we evaluated the pharmacological effects of SI-613 in experimental arthritis models. METHODS: We compared the analgesic and anti-inflammatory effects of intra-articularly administered SI-613, hyaluronic acid (HA), and of orally administered diclofenac sodium (DF-Na) in rat silver nitrate-induced arthritis model and rabbit antigen-induced arthritis model...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29788461/concomitant-fibromyalgia-complicating-chronic-inflammatory-arthritis-a-systematic-review-and-meta-analysis
#11
Stephen J Duffield, Natasha Miller, Sizheng Zhao, Nicola J Goodson
Objectives: This systematic review and meta-analysis will describe the prevalence of concomitant FM in adults with inflammatory arthritis and quantify the impact of FM on DAS. Methods: Cochrane library, MEDLINE, Psychinfo, PubMed, Scopus and Web of Science were searched using key terms and predefined exclusion criteria. As appropriate, proportional and pairwise meta-analysis methods were used to pool results. Results: Forty articles were identified...
May 16, 2018: Rheumatology
https://www.readbyqxmd.com/read/29788448/inhibition-of-endothelial-progenitor-cells-may-explain-the-high-cardiovascular-event-rate-in-patients-with-rheumatoid-arthritis
#12
Mohamad Adawi, Nina Pastuck, Golan Saaida, Rizak Sirchan, Abdalla Watad, Arnon Blum
Background: Rheumatoid arthritis (RA) patients may suffer cardiovascular (CV) events much more than the general population, and CV disease is the leading cause of death in patients with RA. Our hypothesis was that impaired function of endothelial progenitor cells may contribute to endothelial dysfunction and the clinical CV events of patients with RA. Methods: 27 RA patients (9 males and 18 females) with an active disease and 13 healthy subjects who served as the control group (9 males and 4 females) were enrolled to this prospective study...
May 16, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29788152/early-arthritis-is-associated-with-failure-of-immunosuppressive-drugs-and-severe-pediatric-crohn-s-disease-evolution
#13
Naïm Ouldali, Jean-Pierre Hugot, Jérôme Viala, Mohamed Damir, Christine Martinez-Vinson, Ulrich Meinzer
Background: Crohn's disease (CD) is a chronic relapsing inflammatory disease. To optimize therapeutic decision making, it is essential to identify parameters that allow early prediction of a severe disease course. The aim of this study was to assess the link between arthritis and medium-term therapeutic failure in pediatric CD. Methods: We conducted a population-based cohort study with prospectively collected electronic data. To be included, patients must be younger than 17 years and have a confirmed CD diagnosed between 2005 and 2014...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788127/herpes-zoster-in-patients-receiving-jak-inhibitors-for-ulcerative-colitis-mechanism-epidemiology-management-and-prevention
#14
Jean-Frédéric Colombel
Increased risk of herpes zoster (HZ) has been observed in patients with immune-mediated diseases, including rheumatoid arthritis (RA), psoriasis (PsO), and inflammatory bowel disease; this risk can be further increased by the use of immunosuppressive therapy. One advancing modality of therapy for these diseases is Janus kinase (JAK) inhibition. Tofacitinib is an oral JAK inhibitor for the treatment of RA and psoriatic arthritis, which is currently under investigation for the treatment of ulcerative colitis (UC) and was previously investigated for psoriasis...
May 17, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29787856/the-association-of-disease-activity-pro-inflammatory-cytokines-and-neurotrophic-factors-with-depression-in-patients-with-rheumatoid-arthritis
#15
Yun-Hong Cheon, Seung-Geun Lee, Mingyo Kim, Hyun-Ok Kim, Young Sun Suh, Ki-Soo Park, Rock Bum Kim, Hyun-Su Yang, Ji-Min Kim, Chang-Nam Son, Eun Kyoung Park, Sang-Hyon Kim, Sang-Il Lee
Inflammation and trophic factors (brain-derived neurotrophic factor [BDNF], vascular endothelial growth factor, glial cell line-derived neurotrophic factor, and insulin-like growth factor-1) are associated with depression in the general population. Rheumatoid arthritis (RA) is a chronic representative inflammatory autoimmune disease; however, the association of disease activity, pro-inflammatory cytokines, and neurotrophic factors with depression has not been sufficiently investigated. Therefore, we determined the prevalence of depression and risk factors for depression and deterioration of depressive symptoms in RA patients...
May 19, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29787569/association-between-il-6-production-in-synovial-explants-from-rheumatoid-arthritis-patients-and-clinical-and-imaging-response-to-biologic-treatment-a-pilot-study
#16
Martin Andersen, Mikael Boesen, Karen Ellegaard, Kalle Söderström, Niels H Søe, Pieter Spee, Ulrik G W Mørch, Søren Torp-Pedersen, Else M Bartels, Bente Danneskiold-Samsøe, Lars Karlsson, Henning Bliddal
INTRODUCTION: The need for biomarkers which can predict disease course and treatment response in rheumatoid arthritis (RA) is evident. We explored whether clinical and imaging responses to biologic disease modifying anti-rheumatic drug treatment (bDMARD) were associated with the individual's mediator production in explants obtained at baseline. METHODS: RA Patients were evaluated by disease activity score 28 joint C-reactive protein (DAS 28-)), colour Doppler ultrasound (CDUS) and 3 Tesla RA magnetic resonance imaging scores (RAMRIS)...
2018: PloS One
https://www.readbyqxmd.com/read/29786572/dysadipokinemia-in-patients-with-gout-and-its-association-with-the-disease-activity
#17
Inna V Orlova, Mykola A Stanislavchuk, Iryna P Gunko
OBJECTIVE: Introduction: In recent years, the role of adipokines in the development of rheumatic diseases has been a pressing issue. The available data suggest the dysadipokinemia in patients with rheumatoid arthritis, osteoarthritis and psoriatic arthritis. However, there is no data on changes in the levels of adipokines in patients with gout and their association with the activity of inflammatory process. The aim was to study the levels of adipokines in gout patients and evaluate their association with the disease activity...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29786138/association-of-different-immunosuppressive-medications-with-periodontal-condition-in-patients-with-rheumatoid-arthritis-results-from-a-cross-sectional-study
#18
Dirk Ziebolz, Annegret Rupprecht, Jan Schmickler, Laura Bothmann, Juliane Krämer, Daniel Patschan, Gerhard A Müller, Rainer F Mausberg, Jana Schmidt, Gerhard Schmalz, Susann Patschan
BACKGROUND: The aim of this cross-sectional study was to investigate clinical periodontal findings as well as prevalence of selected potentially periodontal pathogenic bacteria in patients with rheumatoid arthritis (RA) treated with different immunosuppressive rheumatic medications. METHODS: 168 patients with RA undergoing different immunosuppressive medications were included and divided into subgroups according to their medication, which was taken in the past six months, in detail I) non-steroidal anti-inflammatory drugs (NSAID) and glucocorticoids combined, and II-VII) different disease modifying anti-rheumatic drugs (DMARDs): II) Methotrexate (MTX), III) Leflunomide, IV) MTX and TNF-α antagonists combined, V) Interleukin-6 (IL-6) antagonist, VI) MTX and Rituximab combined, and VII) combination therapies of more than two of these DMARDs...
May 22, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29785588/sam68-promotes-invasion-migration-and-proliferation-of-fibroblast-like-synoviocytes-by-enhancing-the-nf-%C3%AE%C2%BAb-p65-pathway-in-rheumatoid-arthritis
#19
Weiwei Sun, Rongqin Qin, Rui Wang, Dazhi Ding, Zhaohui Yu, Yuxi Liu, Ruilong Hong, Zhen Cheng, Youhua Wang
Src-associated substrate during mitosis of 68 KDa (Sam68), also known as KH domain containing, RNA binding, signal transduction associated 1 (KHDRBS1), is the prototypic member of the signal transduction activator of RNA (STAR) family of RNA-binding proteins. Previous studies have indicated that Sam68 regulates nuclear transcription factor kappa B (NF-κB) to mediate inflammation. In this study, we analyzed the effect and possible mechanisms of Sam68 in rheumatoid arthritis (RA). By western blot analysis and immunohistochemistry, we found that the expression of Sam68 in synovial tissue of RA patients was increased compared with the control group...
May 21, 2018: Inflammation
https://www.readbyqxmd.com/read/29785401/rheumatoid-arthritis-and-mirnas-a-critical-review-through-a-functional-view
#20
REVIEW
Maria Cristina Moran-Moguel, Stefania Petarra-Del Rio, Evangelina E Mayorquin-Galvan, Maria G Zavala-Cerna
Rheumatoid arthritis (RA) is a systemic autoimmune disease with severe joint inflammation and destruction associated with an inflammatory environment. The etiology behind RA remains to be elucidated; most updated concepts include the participation of environmental, proteomic, epigenetic, and genetic factors. Epigenetic is considered the missing link to explain genetic diversification among RA patients. Within epigenetic factors participating in RA, miRNAs are defined as small noncoding molecules with a length of approximately 22 nucleotides, capable of gene expression modulation, either negatively through inhibition of translation and degradation of the mRNA or positively through increasing the translation rate...
2018: Journal of Immunology Research
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