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https://www.readbyqxmd.com/read/29161138/autologous-matrix-induced-chondrogenesis-a-systematic-review-of-the-clinical-evidence
#1
Liang Gao, Patrick Orth, Magali Cucchiarini, Henning Madry
BACKGROUND: The addition of a type I/III collagen membrane in cartilage defects treated with microfracture has been advocated for cartilage repair, termed "autologous matrix-induced chondrogenesis" (AMIC). PURPOSE: To examine the current clinical evidence regarding AMIC for focal chondral defects. STUDY DESIGN: Systematic review. METHODS: A systematic review was performed by searching PubMed, ScienceDirect, and Cochrane Library databases...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29155616/uncovering-the-power-of-personality-to-shape-income
#2
Jaap J A Denissen, Wiebke Bleidorn, Marie Hennecke, Maike Luhmann, Ulrich Orth, Jule Specht, Julia Zimmermann
The notion of person-environment fit implies that personal and contextual factors interact in influencing important life outcomes. Using data from 8,458 employed individuals, we examined the combined effects of individuals' actual personality traits and jobs' expert-rated personality demands on earnings. Results from a response surface analysis indicated that the fit between individuals' actual personality and the personality demands of their jobs is a predictor of income. Conclusions of this combined analysis were partly opposite to conclusions reached in previous studies using conventional regression methods...
November 1, 2017: Psychological Science
https://www.readbyqxmd.com/read/29149199/epidemiology-and-clinical-profile-of-pathogens-responsible-for-the-hospitalization-of-children-in-sousse-area-tunisia
#3
Ines Brini, Aida Guerrero, Naila Hannachi, Jihene Bouguila, Dorothea Orth-Höller, Amira Bouhlel, Lamia Boughamoura, Benjamin Hetzer, Wegene Borena, Britta Schiela, Dorothee Von Laer, Jalel Boukadida, Heribert Stoiber
This study aimed to identify a broad spectrum of respiratory pathogens from hospitalized and not-preselected children with acute respiratory tract infections in the Farhat Hached University-hospital of Sousse, Tunisia. Between September 2013 and December 2014, samples from 372 children aged between 1 month and 5 years were collected, and tested using multiplex real-time RT-PCR by a commercial assay for 21 respiratory pathogens. In addition, samples were screened for the presence of Streptococcus pneumoniae 16S rDNA using real-time PCR...
2017: PloS One
https://www.readbyqxmd.com/read/29148747/investigation-of-the-iron-peroxo-complex-in-the-fenton-reaction-kinetic-indication-decay-kinetics-and-hydroxyl-radical-yields
#4
Hanna Laura Wiegand, Christian Timon Orths, Klaus Kerpen, Holger Volker Lutze, Torsten Claus Schmidt
The Fenton reaction describes the reaction of Fe(II) with hydrogen peroxide. Several researchers proposed the formation of an intermediate iron-peroxo-complex but experimental evidence for its existence is still missing. The present study investigates formation and life time of this intermediate at various conditions such as different Fe(II)-concentrations, absence vs. presence of a hydroxyl radical scavenger (dimethylsulfoxide, DMSO), and different pH values. Obtained results indicate that the iron-peroxo-complex is formed under all experimental conditions...
November 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29127378/first-insights-into-the-pleiotropic-role-of-vrf-yedf-a-newly-characterized-gene-of-salmonella-typhimurium
#5
Clara Ballesté-Delpierre, Dietmar Fernandez-Orth, Mario Ferrer-Navarro, Ramón Díaz-Peña, Antonia Odena-Caballol, Eliandre Oliveira, Anna Fàbrega, Jordi Vila
Salmonella possesses virulence determinants that allow replication under extreme conditions and invasion of host cells, causing disease. Here, we examined four putative genes predicted to encode membrane proteins (ydiY, ybdJ, STM1441 and ynaJ) and a putative transcriptional factor (yedF). These genes were identified in a previous study of a S. Typhimurium clinical isolate and its multidrug-resistant counterpart. For STM1441 and yedF a reduced ability to interact with HeLa cells was observed in the knock-out mutants, but an increase in this ability was absent when these genes were overexpressed, except for yedF which phenotype was rescued when yedF was restored...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29093460/identifying-critical-recruitment-bottlenecks-limiting-seedling-establishment-in-a-degraded-seagrass-ecosystem
#6
John Statton, Leonardo R Montoya, Robert J Orth, Kingsley W Dixon, Gary A Kendrick
Identifying early life-stage transitions limiting seagrass recruitment could improve our ability to target demographic processes most responsive to management. Here we determine the magnitude of life-stage transitions along gradients in physical disturbance limiting seedling establishment for the marine angiosperm, Posidonia australis. Transition matrix models and sensitivity analyses were used to identify which transitions were critical for successful seedling establishment during the first year of seed recruitment and projection models were used to predict the most appropriate environments and seeding densities...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29089387/fic-mediated-deampylation-is-not-dependent-on-homo-dimerization-and-rescues-toxic-ampylation-in-flies
#7
Amanda K Casey, Andrew T Moehlman, Junmei Zhang, Kelly A Servage, Helmut Krämer, Kim Orth
Protein chaperones play a critical role in proteostasis. The activity of the major endoplasmic reticulum chaperone BiP (GRP78) is regulated by Fic-mediated AMPylation during resting states. By contrast, during times of stress, BiP is deAMPylated. Here, we show that constitutive AMPylation by a constitutively-active FicE247G mutant is lethal in Drosophila. This lethality is cell autonomous as directed expression of the constitutively active mutant FicE247G to the fly eye does not kill the fly but rather results in a rough and reduced eye...
October 31, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29083472/latitude-temperature-and-habitat-complexity-predict-predation-pressure-in-eelgrass-beds-across-the-northern-hemisphere
#8
Pamela L Reynolds, John J Stachowicz, Kevin Hovel, Christoffer Boström, Katharyn Boyer, Mathieu Cusson, Johan S Eklöf, Friederike G Engel, Aschwin H Engelen, Britas Klemens Eriksson, F Joel Fodrie, John N Griffin, Clara Hereu, Masakazu Hori, Torrance Hanley, Mikhail Ivanov, Pablo Jorgensen, Claudia Kruschel, Kun-Seop Lee, Karen McGlathery, Per Olav Moksnes, Masahiro Nakaoka, Mary I O'Connor, Nessa O'Connor, Robert J Orth, Francesca Rossi, Jennifer Ruesink, Erik Sotka, Fiona Tomas, Richard K F Unsworth, Matthew A Whalen, J Emmett Duffy
Latitudinal gradients in species interactions are widely cited as potential causes or consequences of global patterns of biodiversity. However, mechanistic studies documenting changes in interactions across broad geographic ranges are limited. We surveyed predation intensity on common prey (live amphipods and gastropods) in communities of eelgrass (Zostera marina) at 48 sites across its Northern Hemisphere range, encompassing over 37(0) of latitude and four continental coastlines. Predation on amphipods declined with latitude on all coasts but declined more strongly along western ocean margins where temperature gradients are steeper...
October 30, 2017: Ecology
https://www.readbyqxmd.com/read/29056919/analysis-of-relations-between-spatiotemporal-movement-regulation-and-performance-of-discrete-actions-reveals-functionality-in-skilled-climbing
#9
REVIEW
Dominic Orth, Graham Kerr, Keith Davids, Ludovic Seifert
In this review of research on climbing expertise, we focus on different measures of climbing performance, including spatiotemporal measures related to fluency and activity states (i.e., discrete actions), adopted by climbers for achieving overall performance goals of getting to the end of a route efficiently and safely. Currently, a broad range of variables have been reported, however, many of these fail to capture how climbers adapt to a route whilst climbing. We argue that spatiotemporal measures should be considered concurrently with evaluation of activity states (such as reaching or exploring) in order gain a more comprehensive picture of how climbers successfully adapt to a route...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29044210/calmodulin-confers-calcium-sensitivity-to-the-stability-of-the-distal-intracellular-assembly-domain-of-kv7-2-channels
#10
Alessandro Alaimo, Eider Nuñez, Paloma Aivar, Juncal Fernández-Orth, Carolina Gomis-Perez, Ganeko Bernardo-Seisdedos, Covadonga Malo, Alvaro Villarroel
Tetrameric coiled-coil structures are present in many ion channels, often adjacent to a calmodulin (CaM) binding site, although the relationship between the two is not completely understood. Here we examine the dynamic properties of the ABCD domain located in the intracellular C-terminus of tetrameric, voltage-dependent, potassium selective Kv7.2 channels. This domain encompasses the CaM binding site formed by helices A and B, followed by helix C, which is linked to the helix D coiled-coil. The data reveals that helix D stabilizes CaM binding, promoting trans-binding (CaM embracing neighboring subunits), and they suggest that the ABCD domain can be exchanged between subunits of the tetramer...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28990420/synaptic-activity-protects-neurons-against-calcium-mediated-oxidation-and-contraction-of-mitochondria-during-excitotoxicity
#11
Constanze Depp, Carlos Bas-Orth, Lisa Schroeder, Andrea Hellwig, Hilmar Bading
AIMS: Excitotoxicity triggered by extrasynaptic N-methyl-d-aspartate-type glutamate receptors has been implicated in many neurodegenerative conditions, including Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, and stroke. Mitochondrial calcium overload leading to mitochondrial dysfunction represents an early event in excitotoxicity. Neurons are rendered resistant to excitotoxicity by previous periods of synaptic activity that activates a nuclear calcium-driven neuroprotective gene program...
November 14, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28980028/-trends-in-educational-inequalities-in-smoking-among-adolescents-in-germany-evidence-from-four-population-based-studies
#12
REVIEW
Benjamin Kuntz, Julia Waldhauer, Irene Moor, Katharina Rathmann, Matthias Richter, Boris Orth, Daniela Piontek, Ludwig Kraus, Johannes Zeiher, Thomas Lampert
BACKGROUND: In Germany, smoking prevalence among adolescents has significantly declined since the early 2000s. However, data show that adolescent smoking rates considerably differ between different types of secondary schools. The aim of our study was to examine how educational inequalities in adolescent smoking behaviour have developed over time. METHODS: Data were used from four population-based studies (each consisting of repeated cross-sectional surveys from 2001-2015): the representative surveys of the Federal Centre for Health Education, the German Health Interview and Examination Survey for Children and Adolescents, the Health Behaviour in School-aged Children Study, and the European School Survey Project on Alcohol and Other Drugs...
October 4, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28968593/gsk3%C3%AE-%C3%AE-a-novel-therapeutic-target-for-neuroendocrine-tumors
#13
Elke Tatjana Aristizabal Prada, Carla Weis, Michael Orth, Michael Lauseker, Gerald Spoettl, Julian Maurer, Ashley Grossman, Christoph Josef Auernhammer, Svenja Nölting, Patricia Grabowski
<br>Introduction: GSK3α/β is a serine/threonine-kinase that plays a critical role in cancer. AIM(S): In this study, we evaluated the effects of the specific GSK3α/β inhibitor AR-A014418 in vitro to gain novel insights into GSK3α/β signaling in NETs. MATERIALS AND METHODS: Human NET cell lines (BON1, QGP1, H727 and GOT1) were treated with different concentrations of AR-A014418 alone and in combination with lovastatin, everolimus, 5-fluorouracil (5-FU) and γ-irradiation...
October 2, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28964884/a-cross-sectional-point-prevalence-survey-to-study-the-environmental-contamination-of-nosocomial-pathogens-in-intensive-care-units-under-real-life-conditions
#14
I Wille, A Mayr, P Kreidl, C Brühwasser, G Hinterberger, A Fritz, W Posch, S Fuchs, A Obwegeser, D Orth-Höller, C Lass-Flörl
BACKGROUND: In intensive care units (ICUs) inanimate surfaces and equipment may be contaminated by nosocomial pathogens, including multi-drug resistant microorganisms. AIMS: To assess the degree of patients' close and distant environmental contamination including healthcare workers' (HCWs) hands with nosocomial pathogens under real life situations and to investigate potential transmission events. METHODS: For the course of three weeks agar contact samples were taken close and distant to the patient area and from HCWs' hands in eight ICUs of a tertiary care hospital in Innsbruck, Austria...
September 27, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28956284/diagnosing-filamentous-fungal-infections-in-immunocompromised-patients-applying-computed-tomography-guided-percutaneous-lung-biopsies-a-12-year-experience
#15
Cornelia Lass-Flörl, Maria Aigner, David Nachbaur, Stephan Eschertzhuber, Brigitte Bucher, Christian Geltner, Romuald Bellmann, Michaela Lackner, Dorothea Orth-Höller, Reinhard Würzner, Günter Weiss, Bernhard Glodny
BACKGROUND: Invasive fungal diseases (IFD) are an important cause of morbidity and mortality in immunocompromised patients, and early diagnosis and management are a challenge. We evaluated the clinical utility of computed tomography (CT)-guided percutaneous lung biopsies in diagnosing IFD. METHODS: Between 2003 and 2014, we analyzed 2671 CT-guided lung biopsies, from which 157 were IFD associated; we aimed to determine microbiological-based diagnostic accuracy of calcofluor white staining (CFWS), culture, Aspergillus antigen detection (GM), broad-range fungal PCR, and Aspergillus PCR per sample...
September 27, 2017: Infection
https://www.readbyqxmd.com/read/28938787/influence-of-age-and-housing-systems-on-properties-of-tibia-and-humerus-of-lohmann-white-hens1-bone-properties-of-laying-hens-in-commercial-housing-systems
#16
P Regmi, N Nelson, R C Haut, M W Orth, D M Karcher
This study was aimed at analyzing bone properties of Lohmann White hens in different commercial housing systems at various points throughout production. Pullets reared in conventional cages (CC) were either continued in CC or moved to enriched colony cages (EN) at 19 weeks. Pullets reared in cage-free aviaries (AV) were moved to AV hen houses. Bone samples were collected from 60 hens at each of 18 and 72 wk and 30 hens at 26 and 56 wk from each housing system. Left tibiae and humeri were broken under uniform bending to analyze mechanical properties...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28934397/a-modifier-of-huntington-s-disease-onset-at-the-mlh1-locus
#17
Jong-Min Lee, Michael J Chao, Denise Harold, Kawther Abu Elneel, Tammy Gillis, Peter Holmans, Lesley Jones, Michael Orth, Richard H Myers, Seung Kwak, Vanessa C Wheeler, Marcy E MacDonald, James F Gusella
Huntington's disease (HD) is a dominantly inherited neurodegenerative disease caused by an expanded CAG repeat in HTT. Many clinical characteristics of HD such as age at motor onset are determined largely by the size of HTT CAG repeat. However, emerging evidence strongly supports a role for other genetic factors in modifying the disease pathogenesis driven by mutant huntingtin. A recent genome-wide association analysis to discover genetic modifiers of HD onset age provided initial evidence for modifier loci on chromosomes 8 and 15 and suggestive evidence for a locus on chromosome 3...
October 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28933889/codevelopment-of-well-being-and-self-esteem-in-romantic-partners-disentangling-the-effects-of-mutual-influence-and-shared-environment
#18
Ulrich Orth, Ruth Yasemin Erol, Thomas Ledermann, Alexander Grob
Common sense suggests that romantic partners tend to be interdependent in their well-being and self-esteem. The authors tested the degree to which codevelopment in romantic partners (i.e., development in similar directions) is due to mutual influence between partners or due to the effects of shared environment, using longitudinal data from 5 samples of couples (N = 4,116 participants). The samples included dating, cohabiting, and married couples, with a broad age range covering young adulthood to old age. The authors used a longitudinal version of the actor-partner interdependence model and examined measures of well-being (life satisfaction, positive affect, negative affect, and depression) and self-esteem...
September 21, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28923581/constraints-representing-a-meta-stable-r%C3%A3-gime-facilitate-exploration-during-practice-and-transfer-of-learning-in-a-complex-multi-articular-task
#19
Dominic Orth, Keith Davids, Ludovic Seifert
Previous investigations have shown that inducing meta-stability in behavior can be achieved by overlapping affordances through constraint manipulation, allowing cooperative and competitive tendencies to functionally coexist. The purpose of this paper was to test a number of conditions applying these design principles on performance during skills practice and transfer. Of additional interest, was whether the existing skill level interacted with the environmental properties of the experimental tasks (varying indoor climbing routes)...
September 16, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28912123/type-vi-secretion-system-mix-effectors-carry-both-antibacterial-and-anti-eukaryotic-activities
#20
Ann Ray, Nika Schwartz, Marcela de Souza Santos, Junmei Zhang, Kim Orth, Dor Salomon
Most type VI secretion systems (T6SSs) described to date are protein delivery apparatuses that mediate bactericidal activities. Several T6SSs were also reported to mediate virulence activities, although only few anti-eukaryotic effectors have been described. Here, we identify three T6SSs in the marine bacterium Vibrio proteolyticus and show that T6SS1 mediates bactericidal activities under warm marine-like conditions. Using comparative proteomics, we find nine potential T6SS1 effectors, five of which belong to the polymorphic MIX-effector class...
November 2017: EMBO Reports
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