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https://www.readbyqxmd.com/read/28447331/understanding-action-and-adventure-sports-participation-an-ecological-dynamics-perspective
#1
Tuomas Immonen, Eric Brymer, Dominic Orth, Keith Davids, Francesco Feletti, Jarmo Liukkonen, Timo Jaakkola
Previous research has considered action and adventure sports using a variety of associated terms and definitions which has led to confusing discourse and contradictory research findings. Traditional narratives have typically considered participation exclusively as the pastime of young people with abnormal characteristics or personalities having unhealthy and pathological tendencies to take risks because of the need for thrill, excitement or an adrenaline 'rush'. Conversely, recent research has linked even the most extreme forms of action and adventure sports to positive physical and psychological health and well-being outcomes...
December 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/28447111/-diagnostics-and-treatment-of-osteoid-osteoma
#2
REVIEW
P Orth, D Kohn
BACKGROUND: Osteoid osteoma is the third most common benign bone tumor and typically induces pain that is worse at night. OBJECTIVE: To identify the epidemiological, pathogenetic, histological and radiological characteristics of osteoid osteoma and to present the broad variety of treatment options. MATERIAL AND METHODS: This review article summarizes relevant clinical studies and meta-analyses on this topic. RESULTS: Osteoid osteoma is characterized by a central nidus smaller than 1...
April 26, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28441425/role-of-route-previewing-strategies-on-climbing-fluency-and-exploratory-movements
#3
Ludovic Seifert, Romain Cordier, Dominic Orth, Yoan Courtine, James L Croft
This study examined the role of route previewing strategies on climbing fluency and on exploratory movements of the limbs, in order to understand whether previewing helps people to perceive and to realize affordances. Eight inexperienced and ten experienced climbers previewed a 10 m high route of 5b difficulty on French scale, then climbed it with a top-rope as fluently as possible. Gaze behavior was collected from an eye tracking system during the preview and allowed us to determine the number of times they scanned the route, and which of four route previewing strategies (fragmentary, ascending, zigzagging, and sequence-of-blocks) they used...
2017: PloS One
https://www.readbyqxmd.com/read/28432099/acute-hepatopancreatic-necrosis-disease-ahpnd-causing-vibrio-parahaemolyticus-strains-maintain-an-antibacterial-type-vi-secretion-system-with-versatile-effector-repertoires
#4
Peng Li, Lisa N Kinch, Ann Ray, Ankur B Dalia, Qian Cong, Linda M Nunan, Andrew Camilli, Nick V Grishin, Dor Salomon, Kim Orth
Acute hepatopancreatic necrosis disease (AHPND) is a newly emerging shrimp disease that has severely damaged the global shrimp industry. AHPND is caused by toxic strains of Vibrio parahaemolyticus (V. parahaemolyticus) that have acquired a "selfish plasmid" encoding the deadly binary toxins PirA(vp)/PirB(vp) To better understand the repertoire of virulence factors in AHPND-causing V. parahaemolyticus, we conducted a comparative analysis using genome sequences of the clinical strain RIMD2210633, environmental non-AHPND and toxic AHPND isolates of V...
April 21, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28421239/weight-bearing-recommendations-after-operative-fracture-treatment-fact-or-fiction-gait-results-with-and-feasibility-of-a-dynamic-continuous-pedobarography-insole
#5
Benedikt J Braun, Nils T Veith, Mika Rollmann, Marcel Orth, Tobias Fritz, Steven C Herath, Jörg H Holstein, Tim Pohlemann
PURPOSE: Rehabilitation after lower-extremity fractures is based on the physicians' recommendation for non-, partial-, or full weight-bearing. Clinical studies rely on this assumption, but continuous compliance or objective loading rates are unknown. The purpose of this study was to determine the compliance to weight-bearing recommendations by introducing a novel, pedobarography system continuously registering postoperative ground forces into ankle, tibial shaft and proximal femur fracture aftercare and test its feasibility for this purpose...
April 19, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28407816/automatic-identification-of-variables-in-epidemiological-datasets-using-logic-regression
#6
Matthias W Lorenz, Negin Ashtiani Abdi, Frank Scheckenbach, Anja Pflug, Alpaslan Bülbül, Alberico L Catapano, Stefan Agewall, Marat Ezhov, Michiel L Bots, Stefan Kiechl, Andreas Orth
BACKGROUND: For an individual participant data (IPD) meta-analysis, multiple datasets must be transformed in a consistent format, e.g. using uniform variable names. When large numbers of datasets have to be processed, this can be a time-consuming and error-prone task. Automated or semi-automated identification of variables can help to reduce the workload and improve the data quality. For semi-automation high sensitivity in the recognition of matching variables is particularly important, because it allows creating software which for a target variable presents a choice of source variables, from which a user can choose the matching one, with only low risk of having missed a correct source variable...
April 13, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28360401/mutational-analysis-of-the-gla-gene-in-mexican-families-with-fabry-disease
#7
Bianca Ethel Gutiérrez-Amavizca, Andreas Gal, Rocío Ortíz-Orozco, Ulrich Orth, Ernesto Prado Montes De Oca, Jaime Paul Gutiérrez-Amavizca, Luis E Figuera
Fabry disease (FD) is a lysosomal storage disorder, which develops due to a deficiency in the hydrolytic enzyme, α-galactosidase A (α-Gal A). Alpha-Gal A hydrolyzes glycosphingolipid globotriaosylceramide (Gb3), and an α-Gal A deficiency leads to Gb3 accumulation in tissues and cells in the body. This pathology is likely to involve multiple systems, but it is generally considered to affect primarily vascular endothelium. In this study, we investigated mutations in the GLA gene, which encodes α-Gal A, in Mexican families with FD...
March 2017: Journal of Genetics
https://www.readbyqxmd.com/read/28355265/effects-of-different-lower-limb-sensory-stimulation-strategies-on-postural-regulation-a-systematic-review-and-meta-analysis
#8
Mei Teng Woo, Keith Davids, Jarmo Liukkonen, Dominic Orth, Jia Yi Chow, Timo Jaakkola
Systematic reviews of balance control have tended to only focus on the effects of single lower-limb stimulation strategies, and a current limitation is the lack of comparison between different relevant stimulation strategies. The aim of this systematic review and meta-analysis was to examine evidence of effects of different lower-limb sensory stimulation strategies on postural regulation and stability. Moderate- to high- pooled effect sizes (Unbiased (Hedges' g) standardized mean differences (SMD) = 0.31-0...
2017: PloS One
https://www.readbyqxmd.com/read/28345610/early-loss-of-subchondral-bone-following-microfracture-is-counteracted-by-bone-marrow-aspirate-in-a-translational-model-of-osteochondral-repair
#9
Liang Gao, Patrick Orth, Kathrin Müller-Brandt, Lars K H Goebel, Magali Cucchiarini, Henning Madry
Microfracture of cartilage defects may induce alterations of the subchondral bone in the mid- and long-term, yet very little is known about their onset. Possibly, these changes may be avoided by an enhanced microfracture technique with additional application of bone marrow aspirate. In this study, full-thickness chondral defects in the knee joints of minipigs were either treated with (1) debridement down to the subchondral bone plate alone, (2) debridement with microfracture, or (3) microfracture with additional application of bone marrow aspirate...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28339226/percolation-via-combined-electrostatic-and-chemical-doping-in-complex-oxide-films
#10
Peter P Orth, Rafael M Fernandes, Jeff Walter, C Leighton, B I Shklovskii
Stimulated by experimental advances in electrolyte gating methods, we investigate theoretically percolation in thin films of inhomogeneous complex oxides, such as La_{1-x}Sr_{x}CoO_{3} (LSCO), induced by a combination of bulk chemical and surface electrostatic doping. Using numerical and analytical methods, we identify two mechanisms that describe how bulk dopants reduce the amount of electrostatic surface charge required to reach percolation: (i) bulk-assisted surface percolation and (ii) surface-assisted bulk percolation...
March 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28335784/the-benefit-of-adjuvant-radiotherapy-after-breast-conserving-surgery-in-older-patients-with-low-risk-breast-cancer-a-meta-analysis-of-randomized-trials
#11
Christiane Matuschek, Edwin Bölke, Jan Haussmann, Svjetlana Mohrmann, Carolin Nestle-Krämling, Peter Arne Gerber, Stefanie Corradini, Klaus Orth, Kai Kammers, Wilfried Budach
PURPOSE/OBJECTIVE(S): It is currently unclear whether patients with low risk breast cancer receiving adjuvant endocrine therapy need adjuvant radiation therapy after breast conserving surgery. The data of randomized trials are available. MATERIALS/METHODS: In a database search 5 randomized trials including in total 3766 mostly elderly patients with early stage breast cancer treated either with adjuvant endocrine therapy or with endocrine therapy and additional whole breast radiation after breast conserving surgery were identified...
March 23, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28334574/microscopy-meet-big-data
#12
Antony Orth, Diane Schaak, Ethan Schonbrun
The analysis of massive microscopy datasets using deep neural networks provides an alternative to molecular labeling to characterize cellular states.
March 22, 2017: Cell Systems
https://www.readbyqxmd.com/read/28288383/effect-of-methoxy-group-position-on-biological-properties-of-18-f-labeled-benzyl-triphenylphosphonium-cations
#13
Shuting Chen, Zuoquan Zhao, Ying Zhang, Wei Fang, Jie Lu, Xianzhong Zhang
INTRODUCTION: (18)F-labeled phosphonium cations targeting mitochondrial membrane potential would be promising for positron emission tomography (PET) myocardial perfusion imaging (MPI). The purpose of this study was to examine the influence of additional methoxy group and its different positions on myocardium uptake and pharmacokinetics properties of (18)F-labeled benzyl triphenylphosphonium cations. METHOD: In this study, three novel (18)F-labeled phosphonium cations, [(18)F]4-(fluoromethyl)benzyltris(4-methoxyphenyl) phosphonium cation (1b), [(18)F]4-(fluoromethyl)benzyltris(2-methoxyphenyl) phosphonium cation (2b) and [(18)F]4-(fluoromethyl)benzyltris(3-methoxyphenyl) phosphonium cation (3b), were efficiently prepared by a One-Pot method starting from the substitution of non-carried-added fluoride-18...
February 24, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28281118/evaluation-of-different-time-schedules-in-training-with-the-da-vinci-simulator
#14
C Güldner, A Orth, P Dworschak, I Diogo, M Mandapathil, A Teymoortash, U Walliczek-Dworschak
BACKGROUND: This prospective study analyzed the effect of different time schedules in training on the main performance outcomes: overall score, time to complete, and economy of motion. METHODS: The study was performed on the da Vinci Skills Simulator from December 2014 to April 2016. Forty robotic novices were randomized into two groups of 20 participants, which trained in the same three exercises but with different intervals between their training sessions. Each group performed training in Peg Board 1 in their first week, Match Board 2 in their second week, and Ring and Rail 2 in their third week...
March 9, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28266655/intact-sensory-motor-network-structure-and-function-in-far-from-onset-premanifest-huntington-s-disease
#15
Martin Gorges, Hans-Peter Müller, Isabella Maria Sophie Mayer, Gesa Sophie Grupe, Thomas Kammer, Georg Grön, Jan Kassubek, G Bernhard Landwehrmeyer, Robert Christian Wolf, Michael Orth
Structural and functional changes attributable to the neurodegenerative process in Huntington's disease (HD) may be evident in HTT CAG repeat expansion carriers before the clinical manifestations of HD. It remains unclear, though, how far from motor onset a consistent signature of the neurodegenerative process in HD can be detected. Twelve far from onset preHD and 22 age-matched healthy control participants underwent volumetric structural magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), and resting-state functional MRI (11 preHD, 22 controls) as well as electrophysiological measurements (12 preHD, 13 controls)...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28236333/on-the-way-to-a-trisanionic-cu3o2-core-for-oxidase-catalysis-evidence-of-an-asymmetric-trinuclear-precursor-stabilised-by-perfluoropinacolate-ligands
#16
Steven F Hannigan, Amanda I Arnoff, Sarah E Neville, June S Lum, James A Golen, Arnold L Rheingold, Nicole Orth, Ivana Ivanović-Burmazović, Patricia Liebhäuser, Thomas Rösener, Julia Stanek, Alexander Hoffmann, Sonja Herres-Pawlis, Linda H Doerrer
Cu(I) complexes of the form A[(R3P)Cu(pinF)] were synthesized and characterized, in which (pinF)2- is the bidentate, oxygen-donating, ligand perfluoropinacolate. Low temperature oxygenation of the A[(R3P)Cu(pinF)] species resulted in a trisanionic bis(μ3-oxo) trinuclear Cu(II,II,III) core that was characterized by UV-vis spectroscopy (λmax, nm (ε, M-1 cm-1)) = (330, 535 (19), 630 (33)), cryospray-ionization mass spectrometry (CSI-MS), and X-band electron paramagnetic resonance (EPR) spectroscopy (derivative resonance at 3300 G, Δms = 2 at 1500 G)...
February 25, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28235983/-a%C3%A2-new-continuous-gait-analysis-system-for-ankle-fracture-aftercare
#17
B J Braun, N T Veith, S C Herath, R Hell, M Rollmann, M Orth, J H Holstein, T Pohlemann
BACKGROUND: Correct aftercare following lower extremity fractures remains a controversial issue. Reliable, clinically applicable weight-bearing recommendations have not yet been defined. The aim of the current study was to establish a new gait analysis insole during physical therapy aftercare of ankle fractures to test patients' continuous, long-term compliance to partial weight-bearing restrictions and investigate whether patients can estimate their weight-bearing compliance. MATERIALS AND METHODS: The postoperative gait of 14 patients after operative treatment of Weber B-type ankle fractures was monitored continuously for six weeks (OpenGO, Moticon GmbH, Munich)...
February 24, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28225061/dictionary-enhanced-imaging-cytometry
#18
Antony Orth, Diane Schaak, Ethan Schonbrun
State-of-the-art high-throughput microscopes are now capable of recording image data at a phenomenal rate, imaging entire microscope slides in minutes. In this paper we investigate how a large image set can be used to perform automated cell classification and denoising. To this end, we acquire an image library consisting of over one quarter-million white blood cell (WBC) nuclei together with CD15/CD16 protein expression for each cell. We show that the WBC nucleus images alone can be used to replicate CD expression-based gating, even in the presence of significant imaging noise...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28196867/synaptic-activity-drives-a-genomic-program-that-promotes-a-neuronal-warburg-effect
#19
Carlos Bas-Orth, Yan-Wei Tan, David Lau, Hilmar Bading
Synaptic activity drives changes in gene expression to promote long lasting adaptations of neuronal structure and function. One example of such an adaptive response is the buildup of acquired neuroprotection, a synaptic activity- and gene transcription-mediated increase in the resistance of neurons against harmful conditions. A hallmark of acquired neuroprotection is the stabilization of mitochondrial structure and function. We therefore re-examined previously identified sets of synaptic activity-regulated genes to identify genes that are directly linked to mitochondrial function...
March 31, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28196044/is-oxinium-losing-its-luster-commentary-on-an-article-by-christopher-j-vertullo-mbbs-fracs-orth-faortha-et-al-twelve-year-outcomes-of-an-oxinium-total-knee-replacement-compared-with-the-same-cobalt-chromium-design-an-analysis-of-17-577-prostheses-from-the-australian
#20
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