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https://www.readbyqxmd.com/read/29339773/postural-adaptations-to-unilateral-knee-joint-hypomobility-induced-by-orthosis-wear-during-gait-initiation
#1
A Delafontaine, P Fourcade, J L Honeine, S Ditcharles, E Yiou
Balance control and whole-body progression during gait initiation (GI) involve knee-joint mobility. Single knee-joint hypomobility often occurs with aging, orthopedics or neurological conditions. The goal of the present study was to investigate the capacity of the CNS to adapt GI organization to single knee-joint hypomobility induced by the wear of an orthosis. Twenty-seven healthy adults performed a GI series on a force-plate in the following conditions: without orthosis ("control"), with knee orthosis over the swing leg ("orth-swing") and with the orthosis over the contralateral stance leg ("orth-stance")...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29339429/the-biochemistry-of-sensing-enteric-pathogens-regulate-type-iii-secretion-in-response-to-environmental-and-host-cues
#2
REVIEW
Nicole J De Nisco, Giomar Rivera-Cancel, Kim Orth
Enteric pathogens employ sophisticated strategies to colonize and infect mammalian hosts. Gram-negative bacteria, such as Escherichia coli, Salmonella, and Campylobacter jejuni, are among the leading causes of gastrointestinal tract infections worldwide. The virulence strategies of many of these Gram-negative pathogens rely on type III secretion systems (T3SSs), which are macromolecular syringes that translocate bacterial effector proteins directly into the host cytosol. However, synthesis of T3SS proteins comes at a cost to the bacterium in terms of growth rate and fitness, both in the environment and within the host...
January 16, 2018: MBio
https://www.readbyqxmd.com/read/29332628/socioeconomic-factors-in-coronary-artery-disease-results-from-the-spirr-cad-study
#3
Kristina Orth-Gomér, Hans-Christian Deter, Anna-Sophia Grün, Christoph Herrmann-Lingen, Christian Albus, Alexandra Bosbach, Karl-Heinz Ladwig, Joram Ronel, Wolfgang Söllner, Martina de Zwaan, Katja Petrowski, Cora Weber
Low socio-economic status (SES) has been associated with an increased coronary risk in Western countries. All stress experiences are more pronounced in low SES patients with stress emanating from problems with family, job, or money. The SPIRR-CAD study offered an excellent opportunity to examine these risk factors in German speaking mildly and medium depressed patients. In the SPIRR CAD study, a German multi centre randomized clinical trial of 450 male and 120 female coronary patients, we examined the standard and psychosocial risk factor profiles in relation to SES, as assessed by educational level...
February 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29315381/chchd10-mutations-p-r15l-and-p-g66v-cause-motoneuron-disease-by-haploinsufficiency
#4
Sarah J Brockmann, Axel Freischmidt, Patrick Oeckl, Kathrin Müller, Srinivas K Ponna, Anika M Helferich, Christoph Paone, Jörg Reinders, Kerstin Kojer, Michael Orth, Manu Jokela, Mari Auranen, Bjarne Udd, Andreas Hermann, Karin M Danzer, Peter Lichtner, Paul Walther, Albert C Ludolph, Peter M Andersen, Markus Otto, Petri Kursula, Steffen Just, Jochen H Weishaupt
Mutations in the mitochondrially located protein CHCHD10 cause motoneuron disease by an unknown mechanism. In this study, we investigate the mutations p.R15L and p.G66V in comparison to wild-type CHCHD10 and the non-pathogenic variant p.P34S in vitro, in patient cells as well as in the vertebrate in vivo model zebrafish. We demonstrate a reduction of CHCHD10 protein levels in p.R15L and p.G66V mutant patient cells to approximately 50%. Quantitative real-time PCR revealed that expression of CHCHD10 p.R15L, but not of CHCHD10 p...
January 5, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29273576/opinion-redefining-the-role-of-the-physician-in-laboratory-medicine-in-the-context-of-emerging-technologies-personalised-medicine-and-patient-autonomy-4p-medicine
#5
REVIEW
Matthias Orth, Maria Averina, Stylianos Chatzipanagiotou, Gilbert Faure, Alexander Haushofer, Vesna Kusec, Augusto Machado, Siraj A Misbah, Wytze Oosterhuis, Kari Pulkki, Patrick J Twomey, Eberhard Wieland
The role of clinical pathologists or laboratory-based physicians is being challenged on several fronts-exponential advances in technology, increasing patient autonomy exercised in the right to directly request tests and the use of non-medical specialists as substitutes. In response, clinical pathologists have focused their energies on the pre-analytical and postanalytical phases of Laboratory Medicine thus emphasising their essential role in individualised medical interpretation of complex laboratory results...
December 22, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29245949/functional-profiling-of-microtumors-to-identify-cancer-associated-fibroblast-derived-drug-targets
#6
Shane R Horman, Jeremy To, John Lamb, Jocelyn H Zoll, Nicole Leonetti, Buu Tu, Rita Moran, Robbin Newlin, John R Walker, Anthony P Orth
Recent advances in chemotherapeutics highlight the importance of molecularly-targeted perturbagens. Although these therapies typically address dysregulated cancer cell proteins, there are increasing therapeutic modalities that take into consideration cancer cell-extrinsic factors. Targeting components of tumor stroma such as vascular or immune cells has been shown to represent an efficacious approach in cancer treatment. Cancer-associated fibroblasts (CAFs) exemplify an important stromal component that can be exploited in targeted therapeutics, though their employment in drug discovery campaigns has been relatively minimal due to technical logistics in assaying for CAF-tumor interactions...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29214177/linked-registries-connecting-rare-diseases-patient-registries-through-a-semantic-web-layer
#7
Pedro Sernadela, Lorena González-Castro, Claudio Carta, Eelke van der Horst, Pedro Lopes, Rajaram Kaliyaperumal, Mark Thompson, Rachel Thompson, Núria Queralt-Rosinach, Estrella Lopez, Libby Wood, Agata Robertson, Claudia Lamanna, Mette Gilling, Michael Orth, Roxana Merino-Martinez, Manuel Posada, Domenica Taruscio, Hanns Lochmüller, Peter Robinson, Marco Roos, José Luís Oliveira
Patient registries are an essential tool to increase current knowledge regarding rare diseases. Understanding these data is a vital step to improve patient treatments and to create the most adequate tools for personalized medicine. However, the growing number of disease-specific patient registries brings also new technical challenges. Usually, these systems are developed as closed data silos, with independent formats and models, lacking comprehensive mechanisms to enable data sharing. To tackle these challenges, we developed a Semantic Web based solution that allows connecting distributed and heterogeneous registries, enabling the federation of knowledge between multiple independent environments...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29213210/german-s3%C3%A2-guideline-nonrestorative-sleep-sleep-disorders-chapter-sleep-related-breathing-disorders-in-adults-short-version-german-sleep-society-deutsche-gesellschaft-f%C3%A3-r-schlafforschung-und-schlafmedizin-dgsm
#8
REVIEW
Geert Mayer, Michael Arzt, Bert Braumann, Joachim H Ficker, Ingo Fietze, Helmut Frohnhofen, Wolfgang Galetke, Joachim T Maurer, Maritta Orth, Thomas Penzel, Hans Pistner, Winfried Randerath, Martin Rösslein, Helmut Sitter, Boris A Stuck
No abstract text is available yet for this article.
2017: Somnologie: Schlafforschung und Schlafmedizin, Somnology: Sleep Research and Sleep Medicine
https://www.readbyqxmd.com/read/29203822/fluorescence-brightness-and-photostability-of-individual-copper-i-oxide-nanocubes
#9
Nafisa Zohora, Ahmad Esmaielzadeh Kandjani, Antony Orth, Hannah M Brown, Mark R Hutchinson, Brant C Gibson
Conventional organic fluorophores lose their ability to fluoresce after repeated exposure to excitation light due to photobleaching. Therefore, research into emerging bright and photostable nanomaterials has become of great interest for a range of applications such as bio-imaging and tracking. Among these emerging fluorophores, metal oxide-based nanomaterials have attracted significant attention as a potential multifunctional material with photocatalytic and angeogenisis abilities in addition to fluorescnce applications...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29174730/how-to-identify-non-tuberculous-mycobacterium-species-by-using-maldi-tof-mass-spectrometry
#10
REVIEW
Fernando Alcaide, J Amlerová, Germán Bou, Pieter-Jan Ceyssens, Pere Coll, Dan Corcoran, Marie-Sarah Fangous, Iván González-Álvarez, Rebecca Gorton, Gilbert Greub, Geneviève Hery-Arnaud, Jaroslav Hrábak, André Ingebretsen, Brigid Lucey, Ivana Marekoviċ, Concepción Mediavilla-Gradolph, James O'Connor, Jim O'Mahony, Onya Opota, Brendan O'Reilly, Dorothea Orth-Höller, Marina Oviaño, Juan José Palacios, Begoña Palop, Arthur Pranada, Lidia Quiroga, David Rodríguez-Temporal, María Jesús Ruiz-Serrano, Griselda Tudó, An van den Bossche, Jakko van Ingen, Belén Rodriguez-Sanchez
BACKGROUND: The implementation of MALDI-TOF MS for microorganism identification has changed the routine of the microbiology laboratories as we knew it. Most microorganisms can now be reliably identified within minutes using this inexpensive, user-friendly methodology. However, its application on the identification of mycobacteria isolates has been hampered by the structure of their cell wall. Improvements in the sample processing method and in the available database have proved key factors for the rapid and reliable identification of non-tuberculous mycobacteria isolates using MALDI-TOF MS AIMS: The main objective is to provide information about the proceedings for the identification of non-tuberculous isolates using MALDI-TOF MS and to review different sample processing methods, available databases and the interpretation of the results...
November 21, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29163284/creative-motor-actions-as-emerging-from-movement-variability
#11
Dominic Orth, John van der Kamp, Daniel Memmert, Geert J P Savelsbergh
In cognitive science, creative ideas are defined as original and feasible solutions in response to problems. A common proposal is that creative ideas are generated across dedicated cognitive pathways. Only after creative ideas have emerged, they can be enacted to solve the problem. We present an alternative viewpoint, based upon the dynamic systems approach to perception and action, that creative solutions emerge in the act rather than before. Creative actions, thus, are as much a product of individual constraints as they are of the task and environment constraints...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29161138/autologous-matrix-induced-chondrogenesis-a-systematic-review-of-the-clinical-evidence
#12
Liang Gao, Patrick Orth, Magali Cucchiarini, Henning Madry
BACKGROUND: The addition of a type I/III collagen membrane in cartilage defects treated with microfracture has been advocated for cartilage repair, termed "autologous matrix-induced chondrogenesis" (AMIC). PURPOSE: To examine the current clinical evidence regarding AMIC for focal chondral defects. STUDY DESIGN: Systematic review. METHODS: A systematic review was performed by searching PubMed, ScienceDirect, and Cochrane Library databases...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29155616/uncovering-the-power-of-personality-to-shape-income
#13
Jaap J A Denissen, Wiebke Bleidorn, Marie Hennecke, Maike Luhmann, Ulrich Orth, Jule Specht, Julia Zimmermann
The notion of person-environment fit implies that personal and contextual factors interact in influencing important life outcomes. Using data from 8,458 employed individuals, we examined the combined effects of individuals' actual personality traits and jobs' expert-rated personality demands on earnings. Results from a response surface analysis indicated that the fit between individuals' actual personality and the personality demands of their jobs is a predictor of income. Conclusions of this combined analysis were partly opposite to conclusions reached in previous studies using conventional regression methods...
November 1, 2017: Psychological Science
https://www.readbyqxmd.com/read/29149199/epidemiology-and-clinical-profile-of-pathogens-responsible-for-the-hospitalization-of-children-in-sousse-area-tunisia
#14
Ines Brini, Aida Guerrero, Naila Hannachi, Jihene Bouguila, Dorothea Orth-Höller, Amira Bouhlel, Lamia Boughamoura, Benjamin Hetzer, Wegene Borena, Britta Schiela, Dorothee Von Laer, Jalel Boukadida, Heribert Stoiber
This study aimed to identify a broad spectrum of respiratory pathogens from hospitalized and not-preselected children with acute respiratory tract infections in the Farhat Hached University-hospital of Sousse, Tunisia. Between September 2013 and December 2014, samples from 372 children aged between 1 month and 5 years were collected, and tested using multiplex real-time RT-PCR by a commercial assay for 21 respiratory pathogens. In addition, samples were screened for the presence of Streptococcus pneumoniae 16S rDNA using real-time PCR...
2017: PloS One
https://www.readbyqxmd.com/read/29148747/investigation-of-the-iron-peroxo-complex-in-the-fenton-reaction-kinetic-indication-decay-kinetics-and-hydroxyl-radical-yields
#15
Hanna Laura Wiegand, Christian Timon Orths, Klaus Kerpen, Holger Volker Lutze, Torsten Claus Schmidt
The Fenton reaction describes the reaction of Fe(II) with hydrogen peroxide. Several researchers proposed the formation of an intermediate iron-peroxo-complex but experimental evidence for its existence is still missing. The present study investigates formation and life time of this intermediate at various conditions such as different Fe(II)-concentrations, absence vs. presence of a hydroxyl radical scavenger (dimethylsulfoxide, DMSO), and different pH values. Obtained results indicate that the iron-peroxo-complex is formed under all experimental conditions...
November 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29127378/first-insights-into-the-pleiotropic-role-of-vrf-yedf-a-newly-characterized-gene-of-salmonella-typhimurium
#16
Clara Ballesté-Delpierre, Dietmar Fernandez-Orth, Mario Ferrer-Navarro, Ramón Díaz-Peña, Antonia Odena-Caballol, Eliandre Oliveira, Anna Fàbrega, Jordi Vila
Salmonella possesses virulence determinants that allow replication under extreme conditions and invasion of host cells, causing disease. Here, we examined four putative genes predicted to encode membrane proteins (ydiY, ybdJ, STM1441 and ynaJ) and a putative transcriptional factor (yedF). These genes were identified in a previous study of a S. Typhimurium clinical isolate and its multidrug-resistant counterpart. For STM1441 and yedF a reduced ability to interact with HeLa cells was observed in the knock-out mutants, but an increase in this ability was absent when these genes were overexpressed, except for yedF which phenotype was rescued when yedF was restored...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29093460/identifying-critical-recruitment-bottlenecks-limiting-seedling-establishment-in-a-degraded-seagrass-ecosystem
#17
John Statton, Leonardo R Montoya, Robert J Orth, Kingsley W Dixon, Gary A Kendrick
Identifying early life-stage transitions limiting seagrass recruitment could improve our ability to target demographic processes most responsive to management. Here we determine the magnitude of life-stage transitions along gradients in physical disturbance limiting seedling establishment for the marine angiosperm, Posidonia australis. Transition matrix models and sensitivity analyses were used to identify which transitions were critical for successful seedling establishment during the first year of seed recruitment and projection models were used to predict the most appropriate environments and seeding densities...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29089387/fic-mediated-deampylation-is-not-dependent-on-homo-dimerization-and-rescues-toxic-ampylation-in-flies
#18
Amanda K Casey, Andrew T Moehlman, Junmei Zhang, Kelly A Servage, Helmut Krämer, Kim Orth
Protein chaperones play a critical role in proteostasis. The activity of the major endoplasmic reticulum chaperone BiP (GRP78) is regulated by Fic-mediated AMPylation during resting states. By contrast, during times of stress, BiP is deAMPylated. Here, we show that constitutive AMPylation by a constitutively-active FicE247G mutant is lethal in Drosophila. This lethality is cell autonomous as directed expression of the constitutively active mutant FicE247G to the fly eye does not kill the fly but rather results in a rough and reduced eye...
October 31, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29083472/latitude-temperature-and-habitat-complexity-predict-predation-pressure-in-eelgrass-beds-across-the-northern-hemisphere
#19
Pamela L Reynolds, John J Stachowicz, Kevin Hovel, Christoffer Boström, Katharyn Boyer, Mathieu Cusson, Johan S Eklöf, Friederike G Engel, Aschwin H Engelen, Britas Klemens Eriksson, F Joel Fodrie, John N Griffin, Clara Hereu, Masakazu Hori, Torrance Hanley, Mikhail Ivanov, Pablo Jorgensen, Claudia Kruschel, Kun-Seop Lee, Karen McGlathery, Per Olav Moksnes, Masahiro Nakaoka, Mary I O'Connor, Nessa O'Connor, Robert J Orth, Francesca Rossi, Jennifer Ruesink, Erik Sotka, Fiona Tomas, Richard K F Unsworth, Matthew A Whalen, J Emmett Duffy
Latitudinal gradients in species interactions are widely cited as potential causes or consequences of global patterns of biodiversity. However, mechanistic studies documenting changes in interactions across broad geographic ranges are limited. We surveyed predation intensity on common prey (live amphipods and gastropods) in communities of eelgrass (Zostera marina) at 48 sites across its Northern Hemisphere range, encompassing over 37(0) of latitude and four continental coastlines. Predation on amphipods declined with latitude on all coasts but declined more strongly along western ocean margins where temperature gradients are steeper...
October 30, 2017: Ecology
https://www.readbyqxmd.com/read/29056919/analysis-of-relations-between-spatiotemporal-movement-regulation-and-performance-of-discrete-actions-reveals-functionality-in-skilled-climbing
#20
REVIEW
Dominic Orth, Graham Kerr, Keith Davids, Ludovic Seifert
In this review of research on climbing expertise, we focus on different measures of climbing performance, including spatiotemporal measures related to fluency and activity states (i.e., discrete actions), adopted by climbers for achieving overall performance goals of getting to the end of a route efficiently and safely. Currently, a broad range of variables have been reported, however, many of these fail to capture how climbers adapt to a route whilst climbing. We argue that spatiotemporal measures should be considered concurrently with evaluation of activity states (such as reaching or exploring) in order gain a more comprehensive picture of how climbers successfully adapt to a route...
2017: Frontiers in Psychology
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