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https://www.readbyqxmd.com/read/28339226/percolation-via-combined-electrostatic-and-chemical-doping-in-complex-oxide-films
#1
Peter P Orth, Rafael M Fernandes, Jeff Walter, C Leighton, B I Shklovskii
Stimulated by experimental advances in electrolyte gating methods, we investigate theoretically percolation in thin films of inhomogeneous complex oxides, such as La_{1-x}Sr_{x}CoO_{3} (LSCO), induced by a combination of bulk chemical and surface electrostatic doping. Using numerical and analytical methods, we identify two mechanisms that describe how bulk dopants reduce the amount of electrostatic surface charge required to reach percolation: (i) bulk-assisted surface percolation and (ii) surface-assisted bulk percolation...
March 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28335784/the-benefit-of-adjuvant-radiotherapy-after-breast-conserving-surgery-in-older-patients-with-low-risk-breast-cancer-a-meta-analysis-of-randomized-trials
#2
Christiane Matuschek, Edwin Bölke, Jan Haussmann, Svjetlana Mohrmann, Carolin Nestle-Krämling, Peter Arne Gerber, Stefanie Corradini, Klaus Orth, Kai Kammers, Wilfried Budach
PURPOSE/OBJECTIVE(S): It is currently unclear whether patients with low risk breast cancer receiving adjuvant endocrine therapy need adjuvant radiation therapy after breast conserving surgery. The data of randomized trials are available. MATERIALS/METHODS: In a database search 5 randomized trials including in total 3766 mostly elderly patients with early stage breast cancer treated either with adjuvant endocrine therapy or with endocrine therapy and additional whole breast radiation after breast conserving surgery were identified...
March 23, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28334574/microscopy-meet-big-data
#3
Antony Orth, Diane Schaak, Ethan Schonbrun
The analysis of massive microscopy datasets using deep neural networks provides an alternative to molecular labeling to characterize cellular states.
March 22, 2017: Cell Systems
https://www.readbyqxmd.com/read/28288383/effect-of-methoxy-group-position-on-biological-properties-of-18-f-labeled-benzyl-triphenylphosphonium-cations
#4
Shuting Chen, Zuoquan Zhao, Ying Zhang, Wei Fang, Jie Lu, Xianzhong Zhang
INTRODUCTION: (18)F-labeled phosphonium cations targeting mitochondrial membrane potential would be promising for positron emission tomography (PET) myocardial perfusion imaging (MPI). The purpose of this study was to examine the influence of additional methoxy group and its different positions on myocardium uptake and pharmacokinetics properties of (18)F-labeled benzyl triphenylphosphonium cations. METHOD: In this study, three novel (18)F-labeled phosphonium cations, [(18)F]4-(fluoromethyl)benzyltris(4-methoxyphenyl) phosphonium cation (1b), [(18)F]4-(fluoromethyl)benzyltris(2-methoxyphenyl) phosphonium cation (2b) and [(18)F]4-(fluoromethyl)benzyltris(3-methoxyphenyl) phosphonium cation (3b), were efficiently prepared by a One-Pot method starting from the substitution of non-carried-added fluoride-18...
February 24, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28281118/evaluation-of-different-time-schedules-in-training-with-the-da-vinci-simulator
#5
C Güldner, A Orth, P Dworschak, I Diogo, M Mandapathil, A Teymoortash, U Walliczek-Dworschak
BACKGROUND: This prospective study analyzed the effect of different time schedules in training on the main performance outcomes: overall score, time to complete, and economy of motion. METHODS: The study was performed on the da Vinci Skills Simulator from December 2014 to April 2016. Forty robotic novices were randomized into two groups of 20 participants, which trained in the same three exercises but with different intervals between their training sessions. Each group performed training in Peg Board 1 in their first week, Match Board 2 in their second week, and Ring and Rail 2 in their third week...
March 9, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28266655/intact-sensory-motor-network-structure-and-function-in-far-from-onset-premanifest-huntington-s-disease
#6
Martin Gorges, Hans-Peter Müller, Isabella Maria Sophie Mayer, Gesa Sophie Grupe, Thomas Kammer, Georg Grön, Jan Kassubek, G Bernhard Landwehrmeyer, Robert Christian Wolf, Michael Orth
Structural and functional changes attributable to the neurodegenerative process in Huntington's disease (HD) may be evident in HTT CAG repeat expansion carriers before the clinical manifestations of HD. It remains unclear, though, how far from motor onset a consistent signature of the neurodegenerative process in HD can be detected. Twelve far from onset preHD and 22 age-matched healthy control participants underwent volumetric structural magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), and resting-state functional MRI (11 preHD, 22 controls) as well as electrophysiological measurements (12 preHD, 13 controls)...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28236333/on-the-way-to-a-trisanionic-cu3o2-core-for-oxidase-catalysis-evidence-of-an-asymmetric-trinuclear-precursor-stabilised-by-perfluoropinacolate-ligands
#7
Steven F Hannigan, Amanda I Arnoff, Sarah E Neville, June S Lum, James A Golen, Arnold L Rheingold, Nicole Orth, Ivana Ivanović-Burmazović, Patricia Liebhäuser, Thomas Rösener, Julia Stanek, Alexander Hoffmann, Sonja Herres-Pawlis, Linda H Doerrer
Cu(I) complexes of the form A[(R3P)Cu(pinF)] were synthesized and characterized, in which (pinF)2- is the bidentate, oxygen-donating, ligand perfluoropinacolate. Low temperature oxygenation of the A[(R3P)Cu(pinF)] species resulted in a trisanionic bis(μ3-oxo) trinuclear Cu(II,II,III) core that was characterized by UV-vis spectroscopy (λmax, nm (ε, M-1 cm-1)) = (330, 535 (19), 630 (33)), cryospray-ionization mass spectrometry (CSI-MS), and X-band electron paramagnetic resonance (EPR) spectroscopy (derivative resonance at 3300 G, Δms = 2 at 1500 G)...
February 25, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28235983/-a%C3%A2-new-continuous-gait-analysis-system-for-ankle-fracture-aftercare
#8
B J Braun, N T Veith, S C Herath, R Hell, M Rollmann, M Orth, J H Holstein, T Pohlemann
BACKGROUND: Correct aftercare following lower extremity fractures remains a controversial issue. Reliable, clinically applicable weight-bearing recommendations have not yet been defined. The aim of the current study was to establish a new gait analysis insole during physical therapy aftercare of ankle fractures to test patients' continuous, long-term compliance to partial weight-bearing restrictions and investigate whether patients can estimate their weight-bearing compliance. MATERIALS AND METHODS: The postoperative gait of 14 patients after operative treatment of Weber B-type ankle fractures was monitored continuously for six weeks (OpenGO, Moticon GmbH, Munich)...
February 24, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28225061/dictionary-enhanced-imaging-cytometry
#9
Antony Orth, Diane Schaak, Ethan Schonbrun
State-of-the-art high-throughput microscopes are now capable of recording image data at a phenomenal rate, imaging entire microscope slides in minutes. In this paper we investigate how a large image set can be used to perform automated cell classification and denoising. To this end, we acquire an image library consisting of over one quarter-million white blood cell (WBC) nuclei together with CD15/CD16 protein expression for each cell. We show that the WBC nucleus images alone can be used to replicate CD expression-based gating, even in the presence of significant imaging noise...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28196867/synaptic-activity-drives-a-genomic-program-that-promotes-a-neuronal-warburg-effect
#10
Carlos Bas-Orth, Yan-Wei Tan, David Lau, Hilmar Bading
Synaptic activity drives changes in gene expression to promote long-lasting adaptations of neuronal structure and function. One example of such an adaptive response is the buildup of acquired neuroprotection, a synaptic activity- and gene transcription-mediated increase in the resistance of neurons against harmful conditions. A hallmark of acquired neuroprotection is the stabilization of mitochondrial structure and function. We therefore re-examined previously identified sets of synaptic activity-regulated genes to identify genes that are directly linked to mitochondrial function...
February 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28196044/is-oxinium-losing-its-luster-commentary-on-an-article-by-christopher-j-vertullo-mbbs-fracs-orth-faortha-et-al-twelve-year-outcomes-of-an-oxinium-total-knee-replacement-compared-with-the-same-cobalt-chromium-design-an-analysis-of-17-577-prostheses-from-the-australian
#11
https://www.readbyqxmd.com/read/28194306/a-randomized-exploratory-phase-2-study-in-patients-with-chemotherapy-related-peripheral-neuropathy-evaluating-whole-body-vibration-training-as-adjunct-to-an-integrated-program-including-massage-passive-mobilization-and-physical-exercises
#12
Stefan S Schönsteiner, Heidi Bauder Mißbach, Axel Benner, Silja Mack, Thomas Hamel, Michael Orth, Bernhard Landwehrmeyer, Sigurd D Süßmuth, Carolin Geitner, Regine Mayer-Steinacker, Anneliese Riester, Andrea Prokein, Elfriede Erhardt, Jelena Kunecki, Anna M Eisenschink, Rainer Rawer, Hartmut Döhner, Elisabeth Kirchner, Richard F Schlenk
BACKGROUND: Chemotherapy-induced polyneuropathy (CIPN) is a common toxicity after chemotherapy, immunomodulatory drugs or proteasome inhibitors, which is difficult to treat and may also have impact on quality of life. The objective of the study was to evaluate whole-body vibration (WBV) on the background of an integrated program (IP) including massage, passive mobilization and physical exercises on CIPN. PATIENTS AND METHODS: In an exploratory phase-2 study patients with CIPN (NCI CTC grade 2/3) were randomized for WBV plus IP (experimental) to IP alone (standard)...
2017: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/28182449/the-family-environment-in-early-childhood-has-a-long-term-effect-on-self-esteem-a-longitudinal-study-from-birth-to-age-27-years
#13
Ulrich Orth
A better understanding is needed of the factors that shape the development of individual differences in self-esteem. Using a prospective longitudinal design, this research tested whether the family environment in early childhood predicts self-esteem in later developmental periods. Data came from a nationally representative U.S. sample of 8,711 participants, who reported on their self-esteem biannually from age 8 to 27 years. Moreover, during the participants' first 6 years of life, biannual assessments of their mothers provided information on the quality of the home environment (covering quality of parenting, cognitive stimulation, and physical home environment), quality of parental relationship, presence of father, maternal depression, and poverty status of the family...
February 9, 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28176612/comparison-of-the-sysmex-xt-2000iv-with-microscopic-differential-counts-of-canine-bone-marrow
#14
Iris Pernecker, Natali B Bauer, Sigrid Johannes, Melanie Ginder, Johannes H Harleman, Andreas Moritz
Canine bone marrow is frequently assessed in the advanced preclinical research environment. Automated analysis provides time savings and objectivity over the gold standard of microscopic (cytologic) evaluation. We compared the analysis of 90 canine bone marrow samples by the Sysmex XT-2000iV hematology analyzer (Sysmex Corp., Kobe, Japan) with cytologic evaluation. Gates for cell populations were created in the system's WBC/BASO channel. Variables "total nucleated red blood cells" (total_NRBC), "poly- and orthochromatic nucleated red blood cells" (poly_orth_NRBC), "total neutrophils" (total_NEUT), "mature neutrophils" (mature_NEUT), and myeloid-to-erythroid (M:E) ratio were compared with cytologic evaluation...
January 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28170175/genetic-modification-of-human-peripheral-blood-aspirates-using-recombinant-adeno-associated-viral-vectors-for-articular-cartilage-repair-with-a-focus-on-chondrogenic-transforming-growth-factor-%C3%AE-gene-delivery
#15
Janina Frisch, Patrick Orth, Jagadeesh Kumar Venkatesan, Ana Rey-Rico, Gertrud Schmitt, Dieter Kohn, Henning Madry, Magali Cucchiarini
Transplantation of genetically modified peripheral blood aspirates that carry chondrogenically competent progenitor cells may offer new, convenient tools to treat articular cartilage lesions compared with the more complex and invasive application of bone marrow concentrates or of bone marrow-derived mesenchymal stem cells. Here, we show that recombinant adeno-associated viral (rAAV) vectors are powerful gene vehicles capable of successfully targeting primary human peripheral blood aspirates in a stable and safe manner, allowing for an efficient and long-term transgene expression in such samples (up to 63 days with use of a lacZ reporter gene and for at least 21 days with application of the pleiotropic, chondrogenic factor transforming growth factor-β [TGF-β])...
January 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28168210/white-matter-predicts-functional-connectivity-in-premanifest-huntington-s-disease
#16
Peter McColgan, Sarah Gregory, Adeel Razi, Kiran K Seunarine, Fatma Gargouri, Alexandra Durr, Raymund A C Roos, Blair R Leavitt, Rachael I Scahill, Chris A Clark, Sarah J Tabrizi, Geraint Rees, A Coleman, J Decolongon, M Fan, T Petkau, C Jauffret, D Justo, S Lehericy, K Nigaud, R Valabrègue, A Choonderbeek, E P T Hart, D J Hensman Moss, H Crawford, E Johnson, M Papoutsi, C Berna, R Reilmann, N Weber, J Stout, I Labuschagne, B Landwehrmeyer, M Orth, H Johnson
OBJECTIVES: The distribution of pathology in neurodegenerative disease can be predicted by the organizational characteristics of white matter in healthy brains. However, we have very little evidence for the impact these pathological changes have on brain function. Understanding any such link between structure and function is critical for understanding how underlying brain pathology influences the progressive behavioral changes associated with neurodegeneration. Here, we demonstrate such a link between structure and function in individuals with premanifest Huntington's...
February 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28165203/multiple-stressors-threaten-the-imperiled-coastal-foundation-species-eelgrass-zostera-marina-in-chesapeake-bay-usa
#17
Jonathan S Lefcheck, David J Wilcox, Rebecca R Murphy, Scott R Marion, Robert J Orth
Interactions among global change stressors and their effects at large scales are often proposed, but seldom evaluated. This situation is primarily due to lack of comprehensive, sufficiently long-term, and spatially extensive datasets. Seagrasses, which provide nursery habitat, improve water quality, and constitute a globally important carbon sink, are among the most vulnerable habitats on the planet. Here, we unite 31 years of high-resolution aerial monitoring and water quality data to elucidate the patterns and drivers of eelgrass (Zostera marina) abundance in Chesapeake Bay, USA, one of the largest and most valuable estuaries in the world, with an unparalleled history of regulatory efforts...
February 6, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28149323/the-european-network-on-psychosomatic-medicine-enpm-history-and-future-directions
#18
REVIEW
Hans-Christian Deter, Kristina Orth-Gomér, Bohdan Wasilewski, Ramiro Verissimo
BACKGROUND: Within national and international societies of psychosomatic medicine the idea has emerged of bringing together and coordinating psychosomatic, behavioural, psychological and medical actions with common interests throughout Europe as a way to increase their scientific and political influence. METHODS: It was felt that there was a strong need and opportunity of a common and unifying forum for scientific exchange. RESULTS: It was considered desirable to exchange scientific thoughts and experiences in an open minded and boundless way, among individuals and societies, between disciplines and across borders...
2017: BioPsychoSocial Medicine
https://www.readbyqxmd.com/read/28139287/depletion-rate-of-hydrogen-peroxide-from-sodium-perborate-bleaching-agent
#19
Liliann Tran, Rebecca Orth, Peter Parashos, Ying Tao, Calvin W J Tee, Vineet Thenalil Thomas, Georgina Towers, Diem Thuy Truong, Cynthia Vinen, Eric C Reynolds
INTRODUCTION: Internal bleaching of discolored teeth uses sodium perborate reacting with water to form the active agent, hydrogen peroxide (H2O2). Sodium perborate is replaced at varying time intervals depending on clinician preference and until esthetically acceptable results are achieved, but this is done without scientific basis. This study measured the depletion rate of hydrogen peroxide from sodium perborate as a bleaching agent. METHODS: Two sodium perborate bleaching products (Odontobleach [Australian Dental Manufacturing, Kenmore Hills, Queensland, Australia] and Endosure Perborate Micro [Dentalife, Ringwood, Victoria, Australia]) and distilled deionized water mixtures at ratios of 25 μg/mL, 50 μg/mL, and 100 μg/mL were placed into sealed microtubes and incubated at 37°C...
March 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28129014/biochemical-basis-for-activation-of-virulence-genes-by-bile-salts-in-vibrio-parahaemolyticus
#20
Giomar Rivera-Cancel, Kim Orth
Bile salts act as a stressor to bacteria that transit the intestinal tract. Enteric pathogens have hijacked bile as an intestinal signal to regulate virulence factors. We recently demonstrated that Vibrio parahemolyticus senses bile salts via a heterodimeric receptor formed by the periplasmic domains of inner-membrane proteins VtrA and VtrC. Crystal structures of the periplasmic complex reveal that VtrA and VtrC form a β-barrel that binds bile salts in its hydrophobic interior to activate the VtrA cytoplasmic DNA-binding domain...
January 27, 2017: Gut Microbes
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