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Customized CXL

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https://www.readbyqxmd.com/read/27221267/predictors-for-treatment-outcomes-after-corneal-crosslinking-for-keratoconus-a-validation-study
#1
Daniel A Godefrooij, Kim Boom, Nienke Soeters, Saskia M Imhof, Robert P L Wisse
Previous research suggested that baseline corrected distance visual acuity (CDVA) and maximum keratometry (Kmax) are the predictors for effectiveness of corneal crosslinking (CXL) for keratoconus. The aim of this study was to validate the previously determined predictors in a new treatment cohort. A prospective cohort of 112 eyes in 90 consecutive patients was used to validate the results of 102 eyes in 79 patients from our previous prospective cohort. All patients were treated using epithelium-off corneal CXL in a tertiary hospital setting...
May 24, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27097560/outcomes-of-corneal-collagen-crosslinking-using-a-customized-epithelial-debridement-technique-in-keratoconic-eyes-with-thin-corneas
#2
Nurullah Cagil, Ozge Sarac, Gamze Dereli Can, Emine Akcay, Mehmet Erol Can
The purpose of the study was to evaluate the outcomes and possible complications of CXL performed with customized epithelial debridement technique to keratoconic corneas with the thinnest pachymetry values less than 400 µm. Nineteen eyes of 19 patients were included. The uncorrected (UCVA) and best corrected visual acuity (BCVA), flattest and steepest keratometric (K) readings, central corneal thickness at the thinnest point (t-CCT), endothelial cell density (ECD) were assessed before and 12 months after CXL...
April 21, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/26944278/customized-corneal-cross-linking-one-year-results
#3
Theo G Seiler, Isaak Fischinger, Tobias Koller, Daniel Zapp, Beatrice E Frueh, Theo Seiler
PURPOSE: To compare the efficacy of customized corneal cross-linking (CXL) with standard CXL. DESIGN: Prospective, nonrandomized comparative clinical study. METHODS: In a prospective study at the Institut für Refraktive und Ophthalmo-Chirurgie (IROC), Zurich, Switzerland, 40 eyes of 40 patients with documented progressive primary keratoconus were treated with customized CXL (n = 20) or standard CXL (n = 20) and followed for 1 year. Customized irradiation patterns had an energy fluence of 9 mW/cm(2) and total energy levels ranging from 5...
June 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/26465887/establishing-corneal-cross-linking-with-riboflavin-and-uv-a-in-the-mouse-cornea-in-vivo-biomechanical-analysis
#4
Arthur Hammer, Sabine Kling, Marc-Olivier Boldi, Olivier Richoz, David Tabibian, J Bradley Randleman, Farhad Hafezi
PURPOSE: To establish corneal cross-linking (CXL) with riboflavin and UV-A in in the mouse cornea in vivo and to develop tools to measure the biomechanical changes observed. METHODS: A total of 55 male C57BL/6 wild-type mice (aged 5 weeks) were divided into 14 groups. Standard CXL parameters were adapted to the anatomy of the mouse cornea, and riboflavin concentration (0.1%-0.5%) and fluence series (0.09-5.4 J/cm²) were performed on the assumption of the endothelial damage thresholds...
October 2015: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/25365551/effects-of-corneal-cross-linking-on-ocular-response-analyzer-waveform-derived-variables-in-keratoconus-and-postrefractive-surgery-ectasia
#5
RANDOMIZED CONTROLLED TRIAL
Katie M Hallahan, Karolinne Rocha, Abhijit S Roy, J Bradley Randleman, R Doyle Stulting, William J Dupps
PURPOSE: To assess changes in Ocular Response Analyzer (ORA) waveforms after UVA/riboflavin corneal collagen cross-linking (CXL) using investigator-derived and manufacturer-supplied morphometric variables in patients with keratoconus (KC) and postrefractive surgery ectasia. DESIGN: Prospective randomized trial of a standard epithelium-off CXL protocol. PARTICIPANTS: Patients with progressive KC (24 eyes of 21 patients) or postrefractive surgery ectasia (27 eyes of 23 patients) were enrolled...
November 2014: Eye & Contact Lens
https://www.readbyqxmd.com/read/25349796/visual-rehabilitation-in-low-moderate-keratoconus-intracorneal-ring-segment-implantation-followed-by-same-day-topography-guided-photorefractive-keratectomy-and-collagen-cross-linking
#6
Ferial M Zeraid, Asma A Jawkhab, Waleed S Al-Tuwairqi, Uchechukwu L Osuagwu
AIM: To present the results of same-day topography-guided photorefractive keratectomy (TG-PRK) and corneal collagen crosslinking (CXL) after previous intrastromal corneal ring segment (ISCR) implantation for keratoconus. METHODS: An experimental clinical study on twenty-one eyes of 19 patients aged 27.1±6.6y (range 19-43y), with low to moderate keratoconus who were selected to undergo customized TG-PRK immediately followed by same-day CXL, 9mo after ISCR implantation in a university ophthalmology clinic...
2014: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/25320955/advances-in-the-technology-of-corneal-cross-linking-for-keratoconus
#7
REVIEW
Grace Lytle
Corneal cross-linking (CXL) with ultraviolet-A (UVA) and riboflavin was introduced over 15 years ago and has been widely adopted as a treatment for keratoconus. Several studies have demonstrated the safety and efficacy of the procedure performed according to a standard protocol. Recent scientific and technological advances have highlighted the opportunity for optimization of the CXL procedure through modifications to this protocol. Advances in the technology of CXL include new riboflavin formulations, higher irradiance UVA sources, and programmable UVA illumination patterns...
November 2014: Eye & Contact Lens
https://www.readbyqxmd.com/read/25114495/customized-epithelial-debridement-for-thin-ectatic-corneas-undergoing-corneal-cross-linking-epithelial-island-cross-linking-technique
#8
Cosimo Mazzotta, Vincenzo Ramovecchi
Thin corneas with a minimum corneal thickness less than 400 μm after epithelial removal represent a contraindication to standard epithelium-off cross-linking (CXL) treatment due to a significant endothelial cell density decrease and potentiality of permanent haze development. Preoperative swelling of the cornea with hypoosmolar riboflavin solutions broadens the spectrum of CXL indications to thin corneas. However the iatrogenic swelling effect might not be durable throughout the CXL procedure increasing the risk of postoperative complications...
2014: Clinical Ophthalmology
https://www.readbyqxmd.com/read/25076897/toric-topographically-customized-transepithelial-pulsed-very-high-fluence-higher-energy-and-higher-riboflavin-concentration-collagen-cross-linking-in-keratoconus
#9
Anastasios John Kanellopoulos, William J Dupps, Ibrahim Seven, George Asimellis
PURPOSE: To report a novel application of toric topographically customized transepithelial collagen cross-linking (CXL) aiming to achieve refractive astigmatic changes in a keratoconic cornea. METHODS: Specially formulated riboflavin transepithelial administration and delivery of high-fluence UVA in a topographically customized pattern was applied in an eye with progressive keratoconus. Visual acuity, cornea clarity, keratometry, topography, and pachymetry with a multitude of modalities, as well as endothelial cell counts were evaluated for >6 months...
May 2014: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/23778880/corneal-resistance-to-shear-force-after-uva-riboflavin-cross-linking
#10
COMPARATIVE STUDY
Anders P Søndergaard, Anders Ivarsen, Jesper Hjortdal
PURPOSE: We evaluated whether UVA-riboflavin collagen cross-linking (CXL) increases transverse stromal shear moduli ex vivo, whether the shear moduli are greater in the anterior compared to the posterior stroma, and whether the shear moduli are affected by CXL. METHODS: The resistance to unidirectional transverse shear of human (n = 18) and porcine (n = 42) corneas was measured in a custom engineered biaxial biomechanical setup at different hydrations. The corneas were separated into untreated, riboflavin solution-treated, and CXL-treated groups...
July 2013: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/23619500/corneal-changes-following-collagen-cross-linking-and-simultaneous-topography-guided-photoablation-with-collagen-cross-linking-for-keratoconus
#11
Prema Padmanabhan, Aishwaryah Radhakrishnan, Abinaya Priya Venkataraman, Nidhi Gupta, Bhaskar Srinivasan
PURPOSE: To compare the outcome of Collagen cross-linking (CXL) with that following topography-guided customized ablation treatment (T-CAT) with simultaneous CXL in eyes with progressive keratoconus. MATERIALS AND METHODS: This was a prospective, non-randomized single centre study of 66 eyes with progressive keratoconus. Of these, 40 eyes underwent CXL and 26 eyes underwent T-CAT + CXL. The refractive, topographic, tomographic and aberrometric changes measured at baseline, 1, 3 and 6 months post-operatively were compared between both groups...
February 2014: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/23583044/corneal-crosslinking-with-riboflavin-and-ultraviolet-a-part-ii-clinical-indications-and-results
#12
Frederik Raiskup, Eberhard Spoerl
Changes in the biomechanical properties of the human cornea play an important role in the pathogenesis of corneal ectatic diseases. A variety of conditions in primary acquired (keratoconus and pellucid marginal degeneration) or secondary induced (iatrogenic keratectasia after excimer refractive laser surgery) corneal ectatic disorders lead to reduced biomechanical resistance. Corneal collagen crosslinking (CXL) has emerged as a promising technique to slow or even to stop the progression of these corneal ectatic pathologies...
April 2013: Ocular Surface
https://www.readbyqxmd.com/read/23447899/clinical-results-of-topography-based-customized-ablations-in-highly-aberrated-eyes-and-keratoconus-ectasia-with-cross-linking
#13
David T C Lin, Simon Holland, Johnson C H Tan, Gregory Moloney
PURPOSE: To report results of a series of highly aberrated corneas treated with a topography-guided excimer laser ablation. METHODS: Retrospective, nonrandomized, consecutive series of eyes treated with topography-guided photorefractive keratectomy (TG-PRK) with the customized topographical neutralization technique (TNT). Cases included postoperative refractive surgery decentered ablations, optical zone enlargement, asymmetrical astigmatism, postoperative radial keratotomy (RK), postoperative keratoplasty, keratoconus combined with collagen cross-linking (CXL), and postoperative LASIK ectasia combined with CXL...
November 2012: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/23152658/simultaneous-topography-guided-prk-followed-by-corneal-collagen-cross-linking-after-lamellar-keratoplasty-for-keratoconus
#14
Leopoldo Spadea, Marino Paroli
BACKGROUND: The purpose of this paper is to report the results of using combined treatment of customized excimer laser-assisted photorefractive keratectomy (PRK) and prophylactic corneal collagen crosslinking (CXL) for residual refractive error in a group of patients who had previously undergone lamellar keratoplasty for keratoconus. METHODS: The study included 14 eyes from 14 patients who had originally been treated for keratoconus in one eye by excimer laser-assisted lamellar keratoplasty (ELLK), and subsequently presented with residual ametropia (-6...
2012: Clinical Ophthalmology
https://www.readbyqxmd.com/read/23022158/photorefractive-keratectomy-followed-by-cross-linking-versus-cross-linking-alone-for-management-of-progressive-keratoconus-two-year-follow-up
#15
COMPARATIVE STUDY
Giovanni Alessio, Milena L'abbate, Carlo Sborgia, Maria Gabriella La Tegola
PURPOSE: To compare visual, refractive, topographic, and corneal higher-order aberration outcome at the 2-year follow-up after customized photorefractive keratectomy (PRK) followed by cross-linking (CXL) as a single procedure versus CXL alone in eyes with progressive keratoconus. DESIGN: Prospective, interventional, nonrandomized clinical trial. METHODS: Seventeen patients (34 eyes) with progressive keratoconus were assigned to 2 groups: the worse eye (17 eyes) was assigned to the PRK plus CXL group and the better eye (17 fellow eyes) was assigned to the CXL group...
January 2013: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/22736617/corneal-biomechanical-properties-from-two-dimensional-corneal-flap-extensiometry-application-to-uv-riboflavin-cross-linking
#16
Sabine Kling, Harilaos Ginis, Susana Marcos
PURPOSE: Corneal biomechanical properties are usually measured by strip extensiometry or inflation methods. We developed a two-dimensional (2D) flap extensiometry technique, combining the advantages of both methods, and applied it to measure the effect of UV-Riboflavin cross-linking (CXL). METHODS: Corneal flaps (13 pig/8 rabbit) from the de-epithelialized anterior stroma (96 μm) were mounted on a custom chamber, consisting of a BK7 lens, a reflective retina, and two reservoirs (filled with Riboflavin and silicone oil)...
2012: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/22624904/comparison-of-front-surface-corneal-topography-and-bowman-membrane-specular-topography-in-keratoconus
#17
COMPARATIVE STUDY
David Touboul, Elodie Trichet, Perry S Binder, Delphine Praud, Camille Seguy, Joseph Colin
PURPOSE: To define the contribution of the corneal epithelium in corneal topography in keratoconus and discuss the implications regarding combined topography-guided photorefractive keratectomy and corneal collagen crosslinking (CXL). SETTING: French National Reference Center for Keratoconus, Bordeaux, France. DESIGN: Case series. METHODS: Specular topographies were performed before and immediately after epithelial removal during conventional CXL surgery in patients with keratoconus...
June 2012: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/22569472/topography-guided-laser-refractive-surgery
#18
REVIEW
Theodore Pasquali, Ronald Krueger
PURPOSE OF REVIEW: Topography-guided laser refractive surgery seeks to correct vision by altering the major refractive surface of the eye. Whereas results are not significantly different from current treatment options for primary surgery, topography-guided treatment is uniquely effective in eyes with corneal irregularity. This review highlights topography-guided ablations, emphasizing recent advances in treating highly aberrated eyes, including treatment for corneal ectasia in conjunction with collagen cross-linking (CXL)...
July 2012: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/21162472/efficacy-of-corneal-collagen-cross-linking-using-a-custom-epithelial-debridement-technique-in-thin-corneas-a-confocal-microscopy-study
#19
Vedat Kaya, Canan Asli Utine, Omer Faruk Yilmaz
PURPOSE: To examine the corneal collagen cross-linking (CXL) effect with a customized epithelial debridement technique in thin corneas using anterior segment optical coherence tomography (OCT) and confocal microscopy. METHODS: Two patients with keratoconus who underwent a customized epithelial debridement technique (preserving the epithelium in thinner corneal regions where the deepithelialized corneal thickness was <400 μm) and subsequent CXL were examined by anterior segment OCT and in vivo confocal microscopy 1 month postoperatively...
June 2011: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/20954679/stability-of-simultaneous-topography-guided-photorefractive-keratectomy-and-riboflavin-uva-cross-linking-for-progressive-keratoconus-case-reports
#20
Ronald R Krueger, A John Kanellopoulos
PURPOSE: To follow the stability of a simultaneously delivered therapy that corrects aberrations and stiffens the corneal collagen of eyes with progressive keratoconus. METHODS: Two patients with progressive keratoconus underwent partial treatment (70% cylinder and sphere up to 50-μm central depth) with topographic customized photorefractive keratectomy (PRK) using the T-CAT module of the ALLEGRETTO WAVE Eye-Q excimer laser (Alcon Laboratories Inc), and then immediate corneal collagen cross-linking (CXL) with riboflavin 0...
October 2010: Journal of Refractive Surgery
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