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https://www.readbyqxmd.com/read/29913535/thrombocytopenia-and-platelet-dysfunction-in-acute-tropical-infectious-diseases
#1
Indri Hapsari Putri, Rahajeng N Tunjungputri, Philip G De Groot, Andre J van der Ven, Quirijn de Mast
Thrombocytopenia is a well-known manifestation of acute tropical infectious diseases. The role of platelets in infections has received much attention recently because of their emerging activities in modulation of inflammatory responses, host defense, and vascular integrity. However, while many studies have addressed thrombocytopenia in tropical infections, abnormalities in platelet function have been largely overlooked. This is an important research gap, as platelet dysfunction may contribute to the bleeding tendency that characterizes some tropical infections...
June 18, 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29912875/accuracy-of-dengue-clinical-diagnosis-with-and-without-ns1-antigen-rapid-test-comparison-between-human-and-bayesian-network-model-decision
#2
Chaitawat Sa-Ngamuang, Peter Haddawy, Viravarn Luvira, Watcharapong Piyaphanee, Sopon Iamsirithaworn, Saranath Lawpoolsri
Differentiating dengue patients from other acute febrile illness patients is a great challenge among physicians. Several dengue diagnosis methods are recommended by WHO. The application of specific laboratory tests is still limited due to high cost, lack of equipment, and uncertain validity. Therefore, clinical diagnosis remains a common practice especially in resource limited settings. Bayesian networks have been shown to be a useful tool for diagnostic decision support. This study aimed to construct Bayesian network models using basic demographic, clinical, and laboratory profiles of acute febrile illness patients to diagnose dengue...
June 18, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29912704/seroepidemiologic-survey-of-crimean-congo-hemorrhagic-fever-virus-in-selected-risk-groups-south-africa
#3
Sabeehah Vawda, Dominique Goedhals, Phillip Armand Bester, Felicity Burt
Crimean Congo hemorrhagic fever virus (CCHFV) is endemic in South Africa, but whether mild undiagnosed cases occur is unclear. In a seroepidemiologic survey, only 2 of 387 adults considered at risk because of occupational or recreational activities had evidence of previous infection. Seroprevalence in South Africa remains low within the groups investigated.
July 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29912693/rat-bite-fever-in-human-with-streptobacillus-notomytis-infection-japan
#4
Yoshihiko Ogawa, Kei Kasahara, Sang-Tae Lee, Takamitsu Ito, Hideo Hasegawa, Sachie Hirose, Shigeru Santo, Atsushi Yoshida, Ryuichi Nakano, Hisakazu Yano, Keiichi Mikasa
We report a case of rat-bite fever in a 94-year-old woman with Streptobacillus notomytis infection. We established an epidemiologic link between exposure to rats and human infection by performing nested PCRs that detected S. notomytis in the intraoral swab specimens obtained from rats captured in the patient's house.
August 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29911161/hantaviruses-and-a-neglected-environmental-determinant
#5
REVIEW
Alexandro Guterres, Elba Regina Sampaio de Lemos
Most human pathogenic hantaviruses cause severe hemorrhagic fevers with a high rate of fatalities, such as occurs due to the genotypes causing hantavirus cardiopulmonary syndrome carried by the New World Sigmodontinae and Neotominae rodents. An increasing number of outbreaks and the possibility of cases spreading over international borders have led to greater interest in these viruses and the environmental determinants that facilitate their transmission. Rodents, shrews, moles and bats act as reservoir hosts of hantaviruses, and within the hantavirus transmission flow, the prevalence and distribution of infection in reservoir hosts is influenced by a range of factors...
June 2018: One Health
https://www.readbyqxmd.com/read/29911153/comparison-of-a-rapid-immuno-chromatography-assay-with-a-standard-elisa-for-the-detection-of-igm-and-igg-antibodies-against-dengue-viruses
#6
Kalamathy Murugananthan, Pethirupillai A D Coonghe, Natkunam Ketheesan, Faseeha Noordeen
A total of 765 blood samples collected from dengue suspected patients admitted to a Teaching Hospital in Sri Lanka were used to compare a rapid ICT assay with a standard ELISA for the detection of anti-dengue virus (DENV) IgM and IgG. Detection accuracy indices including sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), Chi square and Cohen's kappa values were determined for the ICT assay using the ELISA as a comparator for the detection of anti-DENV IgM and IgG. The rapid ICT assay showed a sensitivity of 64%, specificity of 75%, NPV of 68% and PPV of 72% for anti-DENV IgM detection...
June 2018: Virusdisease
https://www.readbyqxmd.com/read/29911144/emergence-of-dengue-in-nepal
#7
REVIEW
Birendra Prasad Gupta, Mahesh Lamsal, Sudhikshya Chaulagain, Ramanuj Rauniyar, Rajani Malla, Smita Shrestha, Roshan Kurmi, Krishna Das Manandhar
Dengue virus is a major health problem in Nepal. The endogenous dengue appeared in 2006 in the country with reported outbreaks in 2010, 2013 and 2016. Eleven years vertical data show there were sporadic cases in all the years and mostly adults between 25 and 40 years of age were infected with dengue virus. Compared with primary infections, secondary infections were observed in relatively larger numbers during the period of 2008-2016. Most of the cases had symptoms of dengue fever; while 7 and 19 cases demonstrated dengue hemorrhagic fever/dengue shock syndrome in 2010 and 2013 respectively...
June 2018: Virusdisease
https://www.readbyqxmd.com/read/29910575/travel-acquired-scrub-typhus-infection-masked-by-dengue-fever-in-a-patient-from-nonendemic-area
#8
Akanksha Garg, Aditi Jain, Rajesh Kashyap
No abstract text is available yet for this article.
April 2018: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29910543/clinicohematological-profile-of-febrile-neutropenia-in-childhood-acute-leukemia-and-utility-of-serum-procalcitonin-levels-in-neutropenic-patients
#9
Rajan Kapoor, Ashish K Simalti, Shuvendu Roy, Pulkit Agarwal
Introduction: This study was planned to explore the clinical and hematological profile of febrile neutropenia (FN) in Indian children with focus on correlation of degree of neutropenia with fever and procalcitonin (PCT) level and the utility of serum PCT levels in cases of FN. Materials and Methods: Children below 12 years, receiving chemotherapy for hematological malignancy having oral temperature more than 100°F and absolute neutrophil count (ANC) below 500/mm3 were included...
May 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29910483/granulocytic-anaplasmosis-in-2-dogs-from-quebec
#10
Sarah Elhamiani Khatat, Deborah Culang, Carolyn Gara-Boivin
Two dogs from Quebec were diagnosed with granulocytic anaplasmosis. They both displayed fever, lethargy, and anorexia. Other clinical signs included vomiting, uveitis, polyarthritis, hepatomegaly, and splenomegaly. Thrombocytopenia, anemia, and lymphopenia were identified in both cases. Cytoplasmic inclusions were observed within neutrophils, and Anaplasma phagocytophilum infection was confirmed by polymerase chain reaction in both dogs.
June 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/29910212/inhibitory-activity-of-hydroxytyrosol-against-streptolysin-o-induced-hemolysis
#11
Kazuyuki Sogawa, Mika Kobayashi, Jun Suzuki, Akihiro Sanda, Yoshio Kodera, Masafumi Fukuyama
 Group A streptococcus is a bacterium that resides in the throat and skin and causes respiratory infection and occasionally glomerulonephritis and rheumatic fever. Streptolysin O (SLO) produced by Streptococcus pyogenes (S. pyogenes) binds to the cell membrane, particularly to that of white and red blood cells, and is toxic to the cells and tissue. In this study, we evaluated the inhibitory activity of water-soluble polyphenols in olives (Olea europaea) against SLO-induced hemolysis. Hydroxytyrosol inhibited SLO-induced hemolytic activity, and the amount required for 50% inhibition of hemolysis was 1...
2018: Biocontrol Science
https://www.readbyqxmd.com/read/29909593/imaging-of-kingella-kingae-musculoskeletal-infections-in-children-a-series-of-5-cases
#12
Jie C Nguyen, Susan L Rebsamen, Michael J Tuite, J Muse Davis, Humberto G Rosas
PURPOSE: Kingella kingae musculoskeletal infections continue to be under-diagnosed and there remains a paucity of literature on its imaging features. The purpose of this manuscript is to review the imaging, clinical, and laboratory findings of microbiology-proven K. kingae infections. MATERIALS AND METHODS: A retrospective review of musculoskeletal infections between January 1, 2013 and Dec 31, 2016 yielded 134 patients from whom 5 patients had confirmed K. kingae infections (3 boys and 2 girls, mean age of 16 months, range 9-38 months)...
June 16, 2018: Emergency Radiology
https://www.readbyqxmd.com/read/29909394/dengue-fever-with-encephalitis-a-rare-phenomenon
#13
Gaurav Baheti, Varshil Mehta, Menka Ramchandani, Gopal Chandra Ghosh
The clinical profile and presentation of patients with dengue fever may differ from asymptomatic infection to the dreadful complications like dengue shock syndrome. However, neurological complications are very rare. Dengue encephalitis occurs by a direct involvement of central nervous system by the dengue virus which is an extremely rare complication. A 33-year-old man presented with fever, vomiting and severe headache. He had one episode of generalised tonic-clonic seizure followed by an altered sensorium on the day of admission to the hospital...
June 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29909069/antimalarial-activity-of-single-dose-dsm265-a-novel-plasmodium-dihydroorotate-dehydrogenase-inhibitor-in-patients-with-uncomplicated-plasmodium-falciparum-or-plasmodium-vivax-malaria-infection-a-proof-of-concept-open-label-phase-2a-study
#14
Alejandro Llanos-Cuentas, Martin Casapia, Raúl Chuquiyauri, Juan-Carlos Hinojosa, Nicola Kerr, Maria Rosario, Stephen Toovey, Robert H Arch, Margaret A Phillips, Felix D Rozenberg, Jade Bath, Caroline L Ng, Annie N Cowell, Elizabeth A Winzeler, David A Fidock, Mark Baker, Jörg J Möhrle, Rob Hooft van Huijsduijnen, Nathalie Gobeau, Nada Araeipour, Nicole Andenmatten, Thomas Rückle, Stephan Duparc
BACKGROUND: DSM265 is a novel, long-duration inhibitor of plasmodium dihydroorotate dehydrogenase (DHODH) with excellent selectivity over human DHODH and activity against blood and liver stages of Plasmodium falciparum. This study aimed to assess the efficacy of DSM265 in patients with P falciparum or Plasmodium vivax malaria infection. METHODS: This proof-of-concept, open-label, phase 2a study was conducted at the Asociación Civil Selva Amazónica in Iquitos, Peru...
June 13, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29908707/autoimmunity-and-b-cell-dyscrasia-in-acute-and-chronic-q-fever-a-review-of-the-literature
#15
REVIEW
Anne F M Jansen, Ruud P H Raijmakers, Stephan P Keijmel, Renate G van der Molen, Gerald M Vervoort, Jos W M van der Meer, Marcel van Deuren, Chantal P Bleeker-Rovers
Q fever infection can lead to chronic Q fever, a potentially lethal disease occurring in 1-5% of patients infected with Coxiella burnetii, characterized by the persistence of this intracellular bacterium. It usually presents as endocarditis, infected vascular aneurysms, or infected vascular prostheses. This systematic review of the literature discusses the various autoimmune syndromes and B-cell dyscrasias in acute and chronic Q fever patients, that may interfere with or impede recognition and diagnosis of Q fever...
June 13, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29907989/high-seroprevalence-of-dengue-virus-indicates-that-dengue-virus-infections-are-frequent-in-central-and-eastern-sudan
#16
Awadalkareem Adam, Tom Schüttoff, Sven Reiche, Christian Jassoy
OBJECTIVES: To determine the seroprevalence of dengue in central and eastern Sudan and the breadth of neutralizing antibody responses. METHODS: Blood was drawn from 483 patients with fever who visited outpatient clinics in Port Sudan, Red Sea state, in three towns in Kassala state and in El Obeid, North Kordofan in December 2012 and January 2013. Sera were tested for dengue virus IgG and IgM by ELISA (Panbio) and sera without serologic evidence of acute infection (IgM negative) were used for the analysis of the seroprevalence...
June 15, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29907560/validation-of-a-natural-language-processing-algorithm-for-detecting-infectious-disease-symptoms-in-primary-care-electronic-medical-records-in-singapore
#17
Antony Hardjojo, Arunan Gunachandran, Long Pang, Mohammed Ridzwan Bin Abdullah, Win Wah, Joash Wen Chen Chong, Ee Hui Goh, Sok Huang Teo, Gilbert Lim, Mong Li Lee, Wynne Hsu, Vernon Lee, Mark I-Cheng Chen, Franco Wong, Jonathan Siung King Phang
BACKGROUND: Free-text clinical records provide a source of information that complements traditional disease surveillance. To electronically harness these records, they need to be transformed into codified fields by natural language processing algorithms. OBJECTIVE: The aim of this study was to develop, train, and validate Clinical History Extractor for Syndromic Surveillance (CHESS), an natural language processing algorithm to extract clinical information from free-text primary care records...
June 11, 2018: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29907534/significant-infections-in-liver-transplant-recipients-undergoing-endoscopic-retrograde-cholangiography-are-few-and-unaffected-by-prophylactic-antibiotics
#18
Divyanshoo R Kohli, Tilak U Shah, Doumit S BouHaidar, Ravi Vachhani, M Shadab Siddiqui
INTRODUCTION: Current practice guidelines recommend prophylactic antibiotics prior to endoscopic retrograde cholangiopancreatography (ERCP) in liver transplant recipients (LTR). This study evaluated the risk of clinically significant infections after ERCP in LTR who received antibiotic prophylaxis compared to those who did not. METHODS: This retrospective case-cohort study evaluated all LTR who underwent elective, outpatient ERCP from 2008 to 2015. Hospitalized patients, pediatric allograft recipients and patients with cholangitis or incomplete biliary drainage were excluded...
May 28, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29907390/clinical-characteristics-of-citrobacter-meningitis-in-adults-high-incidence-in-patients-with-a-postneurosurgical-state-and-strains-not-susceptible-to-third-generation-cephalosporins
#19
Chia-Yi Lien, Jun-Jun Lee, Chun-Chih Chien, Chi-Ren Huang, Cheng-Hsien Lu, Wen-Neng Chang
Adult bacterial meningitis (ABM) caused by Citrobacter (C.) infection is very uncommon and the clinical characteristics of this specific infectious syndrome have not been analyzed in the literature. The clinical characteristics of six Citrobacter ABM patients collected during a study period of 30 years (1986-2015) were enrolled, and they accounted for 1.1% (6/540) of our ABM patients. In this study, a total of 14 patients with Citrobacter ABM (six collected from our hospital and eight from the literature) were included for analysis...
June 12, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29907187/ticks-from-cats-in-the-united-states-patterns-of-infestation-and-infection-with-pathogens
#20
Susan E Little, Anne W Barrett, Yoko Nagamori, Brian H Herrin, Dorothy Normile, Kathleen Heaney, Rob Armstrong
Ticks are an important but under recognized parasitic threat to cats in many areas of the United States. To characterize the species and stages of ticks most commonly recovered from cats and determine the prevalence of disease agents in the ticks, we conducted a survey of ticks removed from cats at veterinary practices in 18 states from April 2016-June 2017. A total of 796 ticks were submitted from 332 cats from 41 different veterinary practices. A single tick was submitted from the majority of cats, with a mean infestation intensity of 2...
June 15, 2018: Veterinary Parasitology
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