keyword
https://read.qxmd.com/read/38531582/effectiveness-of-metformin-to-pregnant-women-with-pcos-to-reduce-spontaneous-abortion-and-gestational-diabetes-mellitus-a-protocol-for-an-overview-of-reviews
#1
JOURNAL ARTICLE
Darmaris Souza Nassif, Bianca Lúcia Januário, Bianca Antunes Sousa, Lehana Thabane, Joelcio Francisco Abbade
INTRODUCTION: Polycystic ovary syndrome (PCOS) is a globally prevalent endocrinological disorder and has been associated with poor pregnancy outcomes, including a higher rate of gestational diabetes and miscarriage. Metformin is among the drugs investigated to improve the prognosis of pregnant women with PCOS. OBJECTIVE: To conduct an overview of systematic reviews examining the effects of metformin versus placebo or no intervention throughout pregnancy among pregnant women with a preconception PCOS diagnosis to reduce the incidence of miscarriage and gestational diabetes...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38503850/metformin-and-progestins-in-women-with-atypical-hyperplasia-or-endometrial-cancer-systematic-review-and-meta-analysis
#2
REVIEW
Leila Adamyan, Laura Pivazyan, Sapiyat Isaeva, Roman Shapovalenko, Araksya Zakaryan
PURPOSE: To assess metformin's effectiveness in adding it to progestin-based hormone therapy for treating atypical endometrial hyperplasia (AEH) and early endometrial cancer (EEC). METHODS: We conducted a systematic review and meta-analysis following PRISMA guidelines (registration number CRD42023399094). We searched databases for studies up to March 2023, including randomized and non-randomized clinical trials in English. RESULTS: Out of 280 studies, 9 studies (1104 patients) were eligible...
March 19, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38494573/insulin-use-during-gestational-and-pre-existing-diabetes-in-pregnancy-a-systematic-review-of-study-design
#3
REVIEW
Kristin Castorino, Beatrice Osumili, Theophilus Lakiang, Kushal Kumar Banerjee, Andrea Goldyn, Carolina Piras de Oliveira
INTRODUCTION: Insulin is the first-line pharmacologic therapy for women with diabetes in pregnancy. However, conducting well-designed randomized clinical trials (RCTs) and achieving recommended glycemic targets remains a challenge for this unique population. This systematic literature review (SLR) aimed to understand the evidence for insulin use in pregnancy and the outcome metrics most often used to characterize its effect on glycemic, maternal and fetal outcomes in gestational diabetes mellitus (GDM) and in pregnant women with diabetes...
March 18, 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/38477938/bushen-huoxue-recipe-inhibits-endometrial-epithelial-mesenchymal-transition-through-the-transforming-growth-factor-%C3%AE-nuclear-factor-kappa-b-pathway-to-improve-polycystic-ovary-syndrome-mediated-infertility
#4
JOURNAL ARTICLE
Hanxue Wu, Peijuan Wu, Ying Zhu, Junjie Li, Haiyan Chen, Hongqiu Zhu
OBJECTIVE: To investigate the target and mechanism of action of Bushen Huoxue Recipe (BSHX) for the treatment of infertility in polycystic ovary syndrome (PCOS), to provide a basis for the development and clinical application of herbal compounds. METHODS: Prediction and validation of active ingredients and targets of BSHX for the treatment of PCOS by using network pharmacology-molecular docking technology. In an animal experiment, the rats were randomly divided into four groups (control group, model group, BSHX group, metformin group, n  = 16 in each group), and letrozole combined with high-fat emulsion gavage was used to establish a PCOS rat model...
December 2024: Gynecological Endocrinology
https://read.qxmd.com/read/38461278/case-report-glycaemic-management-and-pregnancy-outcomes-in-a-woman-with-an-insulin-receptor-mutation-p-met1180lys
#5
JOURNAL ARTICLE
Mairéad T Crowley, Eirena Goulden, Begona Sanchez-Lechuga, Aileen Fleming, Maria Kennelly, Ciara McDonnell, Maria M Byrne
BACKGROUND: Heterozygous insulin receptor mutations (INSR) are associated with insulin resistance, hyperglycaemia and hyperinsulinaemic hypoglycaemia in addition to hyperandrogenism and oligomenorrhoea in women. Numerous autosomal dominant heterozygous mutations involving the INSR β-subunit tyrosine kinase domain resulting in type A insulin resistance have been previously described. We describe the phenotype, obstetric management and neonatal outcomes in a woman with type A insulin resistance caused by a mutation in the β-subunit of the INSR...
March 10, 2024: Clinical Diabetes and Endocrinology
https://read.qxmd.com/read/38460832/metformin-in-pregnancy-and-childhood-neurodevelopmental-outcomes-a-systematic-review-and-meta-analysis
#6
REVIEW
Hannah G Gordon, Jessica A Atkinson, Stephen Tong, Parinaz Mehdipour, Catherine Cluver, Susan P Walker, Anthea C Lindquist, Roxanne M Hastie
OBJECTIVE: To examine the impact of maternal metformin use in pregnancy on offspring neurodevelopmental outcomes. DATA SOURCES: MEDLINE, Embase, and Web of Science (Core Collection) were searched from inception until July 1, 2023. STUDY ELIGIBILITY CRITERIA: Studies of women receiving treatment with metformin at any stage of pregnancy for any indication, with neurodevelopmental data available for their offspring were included. Studies without a control group were excluded...
March 7, 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38421672/perinatal-outcomes-in-early-and-late-gestational-diabetes-mellitus-after-treatment-from-24-28-weeks-gestation-a-tobogm-secondary-analysis
#7
JOURNAL ARTICLE
David Simmons, Jincy Immanuel, William M Hague, Helena Teede, Christopher J Nolan, Michael J Peek, Jeff R Flack, Mark McLean, Vincent Wong, Emily J Hibbert, Alexandra Kautzky-Willer, Jürgen Harreiter, Helena Backman, Emily Gianatti, Arianne Sweeting, Viswanathan Mohan, N Wah Cheung
OBJECTIVE: In most gestational diabetes mellitus (GDM) studies, cohorts have included women combined into study populations without regard to whether hyperglycemia was present earlier in pregnancy. In this study we sought to compare perinatal outcomes between groups: women with early GDM (EGDM group: diagnosis before 20 weeks but no treatment until 24-28 weeks if GDM still present), with late GDM (LGDM group: present only at 24-28 weeks), and with normoglycemia at 24-28 weeks (control subjects)...
February 29, 2024: Diabetes Care
https://read.qxmd.com/read/38414049/first-trimester-hba-1c-in-relation-to-plasma-glucose-concentrations-in-an-oral-glucose-tolerance-test-at-12-to-16-weeks-gestation-a-population-based-study
#8
JOURNAL ARTICLE
Mervi Jokelainen, Hannu Kautiainen, Arja Nenonen, Beata Stach-Lempinen, Miira M Klemetti
BACKGROUND: Early-onset GDM often requires pharmacological treatment and is associated with adverse perinatal outcomes, but data is insufficient regarding the best methods to identify high-risk women requiring early GDM screening. The aim of this study was to analyze the diagnostic accuracy of HbA1c in the prediction of (1) plasma glucose concentrations > 90th percentile in an oral glucose tolerance test (OGTT) at 12-16 weeks' gestation; and (2) pharmacologically treated early- or late-onset GDM...
February 27, 2024: Diabetology & Metabolic Syndrome
https://read.qxmd.com/read/38410342/application-of-physiological-sperm-selection-in-assisted-reproductive-technology-art-for-patients-with-diabetes-mellitus-a-case-report
#9
Krushnali S Kadu, Akash More, Namrata Choudhary, Shilpa Dutta, Jarul Shrivastava, Gauri Gajabe
This case report revolves around a 35-year-old woman and her 39-year-old husband, who have been married for 10 years and were seeking treatment for their secondary infertility. The husband had been diagnosed with diabetes mellitus (DM) for the past seven years and had been on continued medication. Both partners underwent medical evaluations, and the husband was found to have normozoospermia. The wife had a normal ovarian reserve but was still facing difficulties in conception. Previous medical history showed that the husband's DM had been treated with metformin, and the woman had a history of unsuccessful in vitro fertilization (IVF) cycles and one miscarriage upon investigation...
January 2024: Curēus
https://read.qxmd.com/read/38389317/do-maternal-haemodynamics-have-a-causal-influence-on-treatment-for-gestational-diabetes
#10
JOURNAL ARTICLE
Abigail R Anness, Michael Foster, Mohammed W Osman, David Webb, Thompson Robinson, Asma Khalil, Neil Walkinshaw, Hatem A Mousa
BACKGROUND: Arterial stiffening is believed to contribute to the worsening of insulin resistance, and factors which are associated with needing pharmacological treatment of gestational diabetes (GDM), such as maternal obesity or advanced age, are associated with impaired cardiovascular adaptation to pregnancy. In this observational study, we aimed to investigate causal relationships between maternal haemodynamics and treatment requirement amongst women with GDM. METHODS: We assessed maternal haemodynamics in women with GDM, comparing those who remained on dietary treatment with those who required pharmacological management...
December 2024: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://read.qxmd.com/read/38373378/prevention-of-preeclampsia
#11
REVIEW
Fiona Brownfoot, Daniel Lorber Rolnik
Preeclampsia is a relatively common pregnancy complication and constitutes a major cause of morbidity and mortality for mothers and children worldwide. It disproportionally affects low-resource countries. Appropriate identification of individuals at increased risk and prevention of the disease and its complications remain healthcare and research priorities, and the investigation of potential interventions to prevent preeclampsia has driven much of the obstetric research in recent decades. In this article, we review the scientific literature on the topic, highlighting established benefits and remaining questions regarding different non-pharmacological and pharmacological strategies, including exercise, the timing of birth, aspirin and calcium use, among others, as well as potential novel therapies under investigation...
February 15, 2024: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://read.qxmd.com/read/38366810/childbirth-experiences-in-women-with-polycystic-ovary-syndrome-a-cohort-study
#12
JOURNAL ARTICLE
Anne Engtrø Husby, Melanie Rae Simpson, Rebecka Dalbye, Marit Larsen, Eszter Vanky, Tone Shetelig Løvvik
INTRODUCTION: Women with polycystic ovary syndrome (PCOS) have more pregnancy complications like gestational diabetes, hypertension, and preterm labor than other women. Metformin has been used in an attempt to improve pregnancy outcomes. Our study aims to explore childbirth experiences in women with PCOS compared with a reference population. It also explores the potential influence of metformin, obesity, pregnancy complications, and the duration and mode of birth on childbirth experiences...
February 17, 2024: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/38366195/a-loss-of-function-mutation-in-kcnj11-causing-sulfonylurea-sensitive-diabetes-in-early-adult-life
#13
JOURNAL ARTICLE
Natascia Vedovato, Maria V Salguero, Siri Atma W Greeley, Christine H Yu, Louis H Philipson, Frances M Ashcroft
AIMS/HYPOTHESIS: The ATP-sensitive potassium (KATP ) channel couples beta cell electrical activity to glucose-stimulated insulin secretion. Loss-of-function mutations in either the pore-forming (inwardly rectifying potassium channel 6.2 [Kir6.2], encoded by KCNJ11) or regulatory (sulfonylurea receptor 1, encoded by ABCC8) subunits result in congenital hyperinsulinism, whereas gain-of-function mutations cause neonatal diabetes. Here, we report a novel loss-of-function mutation (Ser118Leu) in the pore helix of Kir6...
February 17, 2024: Diabetologia
https://read.qxmd.com/read/38359580/an-overview-of-diabetes-mellitus-in-pregnant-women-with-obesity
#14
REVIEW
Mohammed Bashir, Yassin Fagier, Badreldeen Ahmed, Justin C Konje
Rates of obesity are increasing world-wide with an estimated 1billion people projected to be obese by 2030 if current trends remain unchanged. Obesity currently considered one of the most significant associated factors of non-communicable diseases poses the greatest threat to health. Diabetes mellitus is an important metabolic disorder closely associated with obesity. It is therefore expected that with the increasing rates of obesity, the rates of diabetes in pregnancy will also be rising. This disorder may pre-date pregnancy (diagnosed or undiagnosed and diagnosed for the first time in pregnancy) or may be of onset in pregnancy...
February 10, 2024: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://read.qxmd.com/read/38341207/manchester-intermittent-diet-in-gestational-diabetes-acceptability-study-middas-gdm-a-two-arm-randomised-feasibility-protocol-trial-of-an-intermittent-low-energy-diet-iled-in-women-with-gestational-diabetes-and-obesity-in-greater-manchester
#15
JOURNAL ARTICLE
Elizabeth Dapre, Basil G Issa, Michelle Harvie, Ting-Li Su, Brian McMillan, Andrea Pilkington, Fahmy Hanna, Avni Vyas, Sarah Mackie, James Yates, Benjamin Evans, Womba Mubita, Cheryl Lombardelli
INTRODUCTION: The prevalence of gestational diabetes mellitus (GDM) is rising in the UK and is associated with maternal and neonatal complications. National Institute for Health and Care Excellence guidance advises first-line management with healthy eating and physical activity which is only moderately effective for achieving glycaemic targets. Approximately 30% of women require medication with metformin and/or insulin. There is currently no strong evidence base for any particular dietary regimen to improve outcomes in GDM...
February 10, 2024: BMJ Open
https://read.qxmd.com/read/38339186/infertility-improvement-after-medical-weight-loss-in-women-and-men-a-review-of-the-literature
#16
REVIEW
Polina Pavli, Olga Triantafyllidou, Efthymios Kapantais, Nikolaos F Vlahos, Georgios Valsamakis
Infertility is a modern health problem. Obesity is another expanding health issue associated with chronic diseases among which infertility is also included. This review will focus on the effects of weight loss by medical therapy on fertility regarding reproductive hormonal profile, ovulation rates, time to pregnancy, implantation rates, pregnancy rates, normal embryo development, and live birth rates. We comprised medicine already used for weight loss, such as orlistat and metformin, and emerging medical treatments, such as Glucagon-Like Peptide-1 receptor agonists (GLP-1 RA)...
February 5, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38269492/metformin-adverse-event-profile-a-pharmacovigilance-study-based-on-the-fda-adverse-event-reporting-system-faers-from-2004-to-2022
#17
JOURNAL ARTICLE
Yikuan Du, Jinfeng Zhu, Zhuoming Guo, Zhenjie Wang, Yuni Wang, Mianda Hu, Lingzhi Zhang, Yurong Yang, Jinjin Wang, Yixing Huang, Peiying Huang, Mianhai Chen, Bo Chen, Chun Yang
BACKGROUND: Metformin has the potential for treating numerous diseases, but there are still many unrecognized and unreported adverse events (AEs). METHODS: We selected data from the United States FDA Adverse Event Reporting System (FAERS) database from the first quarter (Q1) of 2004 to the fourth quarter (Q4) of 2022 for disproportionality analysis to assess the association between metformin and related adverse events. RESULTS: In this study 10,500,295 case reports were collected from the FAERS database, of which 56,674 adverse events related to metformin were reported...
January 25, 2024: Expert Review of Clinical Pharmacology
https://read.qxmd.com/read/38256578/gestational-weight-gain-pregnancy-related-complications-and-the-short-term-risks-for-the-offspring
#18
JOURNAL ARTICLE
Milan Lackovic, Milena Jankovic, Sladjana Mihajlovic, Zagorka Milovanovic, Marija Rovcanin, Nikola Mitic, Dejan Nikolic
BACKGROUND AND OBJECTIVES: Maternal obesity influences pregnancy course in several different manners, and imbalanced nutrition during pregnancy may lead to various adverse pregnancy outcomes. Additionally, nutritional status during pregnancy may have implications for the health of the offspring and may possibly influence early motor development in children. The aim of this study was to assess the impact of excessive gestational weight gain (EGWG) on pregnancy outcomes and infant's motor development within the first twelve months of life...
January 13, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38256201/gestational-caloric-restriction-alters-adipose-tissue-methylome-and-offspring-s-metabolic-profile-in-a-swine-model
#19
JOURNAL ARTICLE
Berta Mas-Parés, Sílvia Xargay-Torrent, Gemma Carreras-Badosa, Ariadna Gómez-Vilarrubla, Maria Niubó-Pallàs, Joan Tibau, Josep Reixach, Anna Prats-Puig, Francis de Zegher, Lourdes Ibañez, Judit Bassols, Abel López-Bermejo
Limited nutrient supply to the fetus results in physiologic and metabolic adaptations that have unfavorable consequences in the offspring. In a swine animal model, we aimed to study the effects of gestational caloric restriction and early postnatal metformin administration on offspring's adipose tissue epigenetics and their association with morphometric and metabolic variables. Sows were either underfed (30% restriction of total food) or kept under standard diet during gestation, and piglets were randomly assigned at birth to receive metformin (n = 16 per group) or vehicle treatment (n = 16 per group) throughout lactation...
January 17, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38178780/feeding-metformin-during-pregnancy-and-lactation-periods-improved-learning-and-memory-impairment-in-the-rat-offspring-exposed-to-febrile-seizure-role-of-oxidative-stress-and-inflammatory-response
#20
JOURNAL ARTICLE
Niloofar Khoshroo, Ali Rahimi, Samaneh Kakhki, Fatemeh Kaffashan, Maha Masoudi, Soheil Baharlou, Farimah Beheshti
BACKGROUND: Many clinical evidences have reported the higher risk of seizure in young children and infants after exposure to hyperthermia, which more likely can cause brain damage and affect cognitive function, so, many researches were focused on prevention or treatment of febrile seizure (FS) with minimal adverse effects. Considering the potential effects of oxidative stress as a prominent trigger in FS, and demonstrating the anti-oxidant effects of metformin, the present study aimed to investigate the protective effect of metformin administration in prenatal and lactation periods in rat pups exposed to hyperthermia by which induced seizure...
January 5, 2024: International Journal of Developmental Neuroscience
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