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https://www.readbyqxmd.com/read/29166458/mog-igg-associated-optic-neuritis-is-not-multiple-sclerosis
#1
Bruna Klein da Costa, Giordani Rodrigues Dos Passos, Jefferson Becker, Douglas Kazutoshi Sato
Autoantibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been reported in patients with inflammatory central nervous system disorders including isolated optic neuritis (ON). We compared our MOG-IgG ON patients with multiple sclerosis (MS) patients presenting with ON. METHODS AND RESULTS: Among the total of 38 patients with optic neuropathies, six patients with isolated ON were MOG-IgG positive and eight patients with ON fulfilled the diagnostic criteria for MS. All MS patients were negative for MOG-IgG using a cell-based assay...
October 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29166170/highly-accurate-identification-of-cystic-precursor-lesions-of-pancreatic-cancer-through-targeted-mass-spectrometry-a-phase-iic-diagnostic-study
#2
Karolina S Jabbar, Liisa Arike, Caroline S Verbeke, Riadh Sadik, Gunnar C Hansson
Purpose Pancreatic cystic lesions are common incidental findings on imaging, but up to half may be forerunners of pancreatic cancer. Therefore, accurate differential diagnosis is crucial for correct patient management. Unfortunately, currently available diagnostic methods cannot robustly identify premalignant and malignant pancreatic cystic lesions. Methods Cyst fluid samples obtained by routine endoscopic ultrasound-guided aspiration were used for the analyses. In a cohort of 24 patients, eight biomarker candidates for malignant potential and high-grade dysplasia/cancer were identified by an explorative proteomic approach...
November 22, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29165638/feasibility-of-real-time-molecular-profiling-for-patients-with-newly-diagnosed-glioblastoma-without-mgmt-promoter-hypermethylation-the-nct-neuro-master-match-n2m2-pilot-study
#3
Elke Pfaff, Tobias Kessler, Gnana Prakash Balasubramanian, Anne Berberich, Daniel Schrimpf, Antje Wick, Jürgen Debus, Andreas Unterberg, Martin Bendszus, Christel Herold-Mende, David Capper, Irini Schenkel, Andreas Eisenmenger, Susan Dettmer, Benedikt Brors, Michael Platten, Stefan M Pfister, Andreas von Deimling, David T W Jones, Wolfgang Wick, Felix Sahm
Introduction: O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status is a predictive biomarker in glioblastoma patients. Glioblastoma without hypermethylated MGMT promoter are largely resistant to treatment with temozolomide. These patients are in particular need of new treatment approaches, which are offered by biomarker-driven clinical trials with targeted drugs based on molecular characterization of individual tumors. Methods: In preparation for an upcoming clinical study, a comprehensive molecular profiling approach was undertaken on tissues from 43 glioblastoma patients harboring an unmethylated MGMT promoter at diagnosis...
November 18, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29165496/fluorescence-quenching-based-signal-amplification-on-immunochromatography-test-strips-for-dual-mode-sensing-of-two-biomarkers-of-breast-cancer
#4
Bo Zhang, Wenjuan Ma, Fuxin Li, Weichen Gao, Qian Zhao, Weipan Peng, Jiafang Piao, Xiaoli Wu, Hanjie Wang, Xiaoqun Gong, Jin Chang
Recently, immunochromatography test strips (ICTS) have been fully developed for point-of-care testing (POCT). However, the intrinsic limitations including non-quantitative detection of colloidal gold ICTS and low sensitivity of fluorescence ICTS (FICTS) significantly restrict their further application in clinical diagnosis. Taking advantages of rapid colorimetric qualitative detection and fluorescence quantitation, we designed a kind of sensitive and dual-mode magnetic FICTS (mFICTS) based on PLGA@Fe3O4 super-paramagnetic nanosphere (SPMN) probes quenching multiplex fluorescer on the test line through sandwich immunoreactions...
November 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/29165064/immunosensors-in-early-cancer-diagnostics-from-individual-to-multiple-biomarker-assays
#5
Lucie Korecka, Karel Vytras, Zuzana Bilkova
Cancer is a widespread disease characterized by high mortality. To improve the survival rate or facilitate effective therapy, accurate and reliable diagnosis at an early stage is needed. For this reason, there is a continuous push to develop sensitive methods which can be used in cancer diagnosis. Current diagnosis relies on the quantification of cancer biomarkers defined as molecules that are measurable in body fluids or tissues and indicate a change in physiological processes with subsequent pathological manifestations...
November 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29164851/an-integrated-redox-cycling-for-electrochemical-enzymatic-signal-enhancement
#6
Md Rajibul Akanda, Huangxian Ju
Highly sensitive analytical methods for the detection of proteins are still an urgent demand in early medical diagnosis and discovery of biomarkers with ultralow abundance. Here an integrated electrochemical-chemical-enzymatic redox cycling is designed for significant enhancement of electrochemical enzymatic signal in biorecognition. This strategy efficiently utilizes the high specificity of outer-sphere to inner-sphere redox reaction to mediate the enzymatic redox cycling with the nonenzymatic redox cycling...
November 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29164603/18f-pet-with-florbetapir-for-the-early-diagnosis-of-alzheimer-s-disease-dementia-and-other-dementias-in-people-with-mild-cognitive-impairment-mci
#7
REVIEW
Gabriel Martínez, Robin Wm Vernooij, Paulina Fuentes Padilla, Javier Zamora, Xavier Bonfill Cosp, Leon Flicker
BACKGROUND: (18)F-florbetapir uptake by brain tissue measured by positron emission tomography (PET) is accepted by regulatory agencies like the Food and Drug Administration (FDA) and the European Medicine Agencies (EMA) for assessing amyloid load in people with dementia. Its added value is mainly demonstrated by excluding Alzheimer's pathology in an established dementia diagnosis. However, the National Institute on Aging and Alzheimer's Association (NIA-AA) revised the diagnostic criteria for Alzheimer's disease and confidence in the diagnosis of mild cognitive impairment (MCI) due to Alzheimer's disease may be increased when using amyloid biomarkers tests like (18)F-florbetapir...
November 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29164602/18f-pet-with-flutemetamol-for-the-early-diagnosis-of-alzheimer-s-disease-dementia-and-other-dementias-in-people-with-mild-cognitive-impairment-mci
#8
REVIEW
Gabriel Martínez, Robin Wm Vernooij, Paulina Fuentes Padilla, Javier Zamora, Leon Flicker, Xavier Bonfill Cosp
BACKGROUND: (18)F-flutemetamol uptake by brain tissue, measured by positron emission tomography (PET), is accepted by regulatory agencies like the Food and Drug Administration (FDA) and the European Medicine Agencies (EMA) for assessing amyloid load in people with dementia. Its added value is mainly demonstrated by excluding Alzheimer's pathology in an established dementia diagnosis. However, the National Institute on Aging and Alzheimer's Association (NIA-AA) revised the diagnostic criteria for Alzheimer's disease and the confidence in the diagnosis of mild cognitive impairment (MCI) due to Alzheimer's disease may be increased when using some amyloid biomarkers tests like (18)F-flutemetamol...
November 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29164600/18f-pet-with-florbetaben-for-the-early-diagnosis-of-alzheimer-s-disease-dementia-and-other-dementias-in-people-with-mild-cognitive-impairment-mci
#9
REVIEW
Gabriel Martínez, Robin Wm Vernooij, Paulina Fuentes Padilla, Javier Zamora, Leon Flicker, Xavier Bonfill Cosp
BACKGROUND: (18)F-florbetaben uptake by brain tissue, measured by positron emission tomography (PET), is accepted by regulatory agencies like the Food and Drug Administration (FDA) and the European Medicine Agencies (EMA) for assessing amyloid load in people with dementia. Its added value is mainly demonstrated by excluding Alzheimer's pathology in an established dementia diagnosis. However, the National Institute on Aging and Alzheimer's Association (NIA-AA) revised the diagnostic criteria for Alzheimer's disease and confidence in the diagnosis of mild cognitive impairment (MCI) due to Alzheimer's disease may be increased when using some amyloid biomarkers tests like (18)F-florbetaben...
November 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29164594/rna-sequencing-study-of-peripheral-blood-mononuclear-cells-in-sporadic-meniere-s-disease-patients-possible-contribution-of-immunologic-dysfunction-to-the-development-of-this-disorder
#10
Ying Sun, Daogong Zhang, Gaoying Sun, Yafeng Lv, Yawei Li, Xiaofei Li, Yongdong Song, Jianfeng Li, Zhaomin Fan, Haibo Wang
To date, the pathogenesis of Meniere's disease (MD) remains unclear. This study aims to investigate the possible relationship between potential immune system related genes and sporadic Meniere's disease. The whole RNA-sequencing (RNA-seq) technology was used to analyze the transcriptome of peripheral blood mononuclear cells of 3 MD patients and 3 control individuals. Of 366 differentially expressed genes (DEGs), 154 genes were up-regulated and 212 genes were down-regulated (|log2Foldchange| >1 and p <0...
November 22, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29164307/cartilage-oligomeric-protein-matrix-metalloproteinase-3-and-coll2-1-as-serum-biomarkers-in-knee-osteoarthritis-a-cross-sectional-study
#11
Tsvetoslav Georgiev, Mariana Ivanova, Aleksandar Kopchev, Tsvetelina Velikova, Asen Miloshov, Ekaterina Kurteva, Kalina Yuzeir, Marin Penkov, Plamena Kabakchieva, Rasho Rashkov, Rumen Stoilov
Biochemical markers reflecting joint remodeling in osteoarthritis (OA) are a promising diagnostic tool. The aim of this study was to investigate serum levels of candidate biomarkers in subjects with and without knee OA and assess their correlation with clinical parameters and knee structural damage. 56 patients with primary knee OA and 31 healthy controls participated in this study. Patients were separated into two groups: isolated knee OA and generalized OA. Clinical parameters were obtained by validated self-reported questionnaires and a visual analogue scale...
November 21, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29164064/quantitative-mass-spectrometry-based-proteomic-profiling-for-precision-medicine-in-prostate-cancer
#12
REVIEW
Amilcar Flores-Morales, Diego Iglesias-Gato
Prostate cancer (PCa) is one of the most frequently diagnosed cancer among men in the western societies. Many PCa patients bear tumors that will not threat their lives if left untreated or if treatment is delayed. Our inability for early identification of these patients has resulted in massive overtreatment. Therefore, there is a great need of finding biomarkers for patient stratification according to prognostic risk; as well as there is a need for novel targets that can allow the development of effective treatments for patients that progress to castration-resistant PCa...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29164056/prostate-cancer-imaging-and-biomarkers-guiding-safe-selection-of-active-surveillance
#13
REVIEW
Zachary A Glaser, Jennifer B Gordetsky, Kristin K Porter, Sooryanarayana Varambally, Soroush Rais-Bahrami
Background: Active surveillance (AS) is a widely adopted strategy to monitor men with low-risk, localized prostate cancer (PCa). Current AS inclusion criteria may misclassify as many as one in four patients. The advent of multiparametric magnetic resonance imaging (mpMRI) and novel PCa biomarkers may offer improved risk stratification. We performed a review of recently published literature to characterize emerging evidence in support of these novel modalities. Methods: An English literature search was conducted on PubMed for available original investigations on localized PCa, AS, imaging, and biomarkers published within the past 3 years...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29163821/the-clinical-use-of-circulating-micrornas-as-non-invasive-diagnostic-biomarkers-for-lung-cancers
#14
Yanlong Yang, Zaoxiu Hu, Yongchun Zhou, Guangqiang Zhao, Yujie Lei, Guangjian Li, Shuai Chen, Kai Chen, Zhenghai Shen, Xiao Chen, Peilin Dai, Yunchao Huang
Many studies have investigated the diagnostic role of circulating microRNAs (miRNAs) in patients with lung cancer; however, the results still remain inconclusive. An updated system review and meta-analysis was necessary to give a comprehensive evaluation of diagnostic role of circulating miRNAs in lung cancer. Eligible studies were searched in electronical databases. The sensitivity and specificity were used to plot the summary receiver operator characteristic (SROC) curve and calculate the area under the curve (AUC)...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163812/identification-of-metastasis-associated-micrornas-in-serum-from-rectal-cancer-patients
#15
Robin Mjelle, Kjersti Sellæg, Pål Sætrom, Liv Thommesen, Wenche Sjursen, Eva Hofsli
MicroRNAs (miRNAs) are promising prognostic and diagnostic biomarkers due to their high stability in blood. Here we investigate the expression of miRNAs and other noncoding (nc) RNAs in serum of rectal cancer patients. Serum from 96 rectal cancer patients was profiled using small RNA sequencing and expression of small RNAs was correlated with the clinicopathological characteristics of the patients. Multiple classes of RNAs were detected, including miRNAs and fragments of tRNAs, snoRNAs, long ncRNAs, and other classes of RNAs...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163712/combinations-of-elevated-tissue-mirna-17-92-cluster-expression-and-serum-prostate-specific-antigen-as-potential-diagnostic-biomarkers-for-prostate-cancer
#16
Sujuan Feng, Xiaosong Qian, Han Li, Xiaodong Zhang
The aim of the present study was to investigate the effectiveness of the miR-17-92 cluster as a disease progression marker in prostate cancer (PCa). Reverse transcription-quantitative polymerase chain reaction analysis was used to detect the microRNA (miR)-17-92 cluster expression levels in tissues from patients with PCa or benign prostatic hyperplasia (BPH), in addition to in PCa and BPH cell lines. Spearman correlation was used for comparison and estimation of correlations between miRNA expression levels and clinicopathological characteristics such as the Gleason score and prostate-specific antigen (PSA)...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29163698/cytokeratin-17-mrna-as-a-prognostic-marker-of-oral-squamous-cell-carcinoma
#17
Ryoji Kitamura, Takeshi Toyoshima, Hideaki Tanaka, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Kazunari Oobu, Seiji Nakamura
Despite diagnostic and therapeutic advances, the 5-year survival rate of oral squamous cell carcinoma (OSCC) remains between 70-80% due to recurrences and secondary metastases to cervical lymph nodes. It is difficult to find these recurrences and metastases postoperatively, thus, careful follow-up is recommended. Cytokeratins (CKs) are intermediate filaments of the cytoskeleton and candidate prognostic biomarkers for OSCC, as they are overexpressed in OSCC compared with normal mucosa. The aim of the present study was to determine the relative levels of occurrence of 3 CK mRNA (CK17, CK19, CK20) transcripts in peripheral blood mononuclear cells (PBMC) using reverse transcription-quantitative polymerase chain reaction...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29163685/expression-of-cancer-testis-antigens-mage-a-mage-c1-gage-and-ctag1b-in-benign-and-malignant-thyroid-diseases
#18
Daniel Hardy Melo, Rui Celso Martins Mamede, Luciano Neder, Wilson Araújo Silva, Mateus Camargo Barros-Filho, Luiz Paulo Kowalski, Clóvis Antonio Lopes Pinto, Marco Antônio Zago, David Livingstone Alves Figueiredo, Achim A Jungbluth
Despite considerable advances in the understanding of thyroid gland biology, correctly diagnosing thyroid nodules and treating high-grade thyroid carcinoma remains challenging. Cancer/testis (CT) antigens have emerged as potential diagnostic tools as well as targets of potential cancer vaccinations. In the present study, a total of 117 patients who underwent surgical therapy for thyroid disease were available for analysis. The expression levels of melanoma-associated antigen (MAGE) A, MAGE-C1/CT7, cancer/testis antigen 1B (CTAG1B) and G antigen (GAGE) were analyzed by immunohistochemistry...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29163237/-18f-fluorodeoxyglucose-positron-emission-tomography-in-rats-with-prolonged-cocaine-self-administration-suggests-potential-brain-biomarkers-for-addictive-behavior
#19
Nazzareno Cannella, Alejandro Cosa-Linan, Mareike Roscher, Tatiane T Takahashi, Nils Vogler, Björn Wängler, Rainer Spanagel
The DSM5-based dimensional diagnostic approach defines substance use disorders on a continuum from recreational drug use to habitual and ultimately addicted behavior. Biomarkers that are indicative of recreational drug use and addicted behavior are lacking. We performed a translational [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) study in the multi-dimensional 0/3crit model of cocaine addiction. Addict-like (3crit) and non-addict-like (0crit) rats, which shared identical life conditions and levels of cocaine self-administration, were acquired for FDG-PET under baseline conditions and following cocaine and yohimbine challenges...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29163138/perspective-insights-into-disease-progression-diagnostics-and-therapeutic-approaches-in-alzheimer-s-disease-a-judicious-update
#20
REVIEW
Arif Tasleem Jan, Mudsser Azam, Safikur Rahman, Angham M S Almigeiti, Duk Hwan Choi, Eun Ju Lee, Qazi Mohd Rizwanul Haq, Inho Choi
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive accumulation of β-amyloid fibrils and abnormal tau proteins in and outside of neurons. Representing a common form of dementia, aggravation of AD with age increases the morbidity rate among the elderly. Although, mutations in the ApoE4 act as potent risk factors for sporadic AD, familial AD arises through malfunctioning of APP, PSEN-1, and-2 genes. AD progresses through accumulation of amyloid plaques (Aβ) and neurofibrillary tangles (NFTs) in brain, which interfere with neuronal communication...
2017: Frontiers in Aging Neuroscience
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