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hair follicle stem cell

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https://www.readbyqxmd.com/read/29682604/the-hair-follicle-an-underutilized-source-of-cells-and-materials-for-regenerative-medicine
#1
Mehrdad T Kiani, Claire A Higgins, Benjamin D Almquist
The hair follicle is one of only two structures within the adult body that selectively degenerates and regenerates, making it an intriguing organ to study and use for regenerative medicine. Hair follicles have been shown to influence wound healing, angiogenesis, neurogenesis, and harbor distinct populations of stem cells; this has led to cells from the follicle being used in clinical trials for tendinosis and chronic ulcers. In addition, keratin produced by the follicle in the form of a hair fiber provides an abundant source of biomaterials for regenerative medicine...
April 9, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29672929/functional-anatomy-of-the-hair-follicle-the-secondary-hair-germ
#2
REVIEW
Andrey A Panteleyev
The secondary hair germ (SHG) - a transitory structure in the lower portion of the mouse telogen hair follicle (HF) - is directly involved in anagen induction and eventual HF regrowth. Some crucial aspects of SHG functioning and ontogenetic relations with other HF parts, however, remain undefined. According to recent evidence (in contrast to previous bulge-centric views), the SHG is the primary target of anagen-inducing signaling and a source of both the outer root sheath (ORS) and ascending HF layers during the initial (morphogenetic) anagen sub-phase...
April 19, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29661566/lichen-planopilaris-and-frontal-fibrosing-alopecia-as-model-epithelial-stem-cell-diseases
#3
REVIEW
Matthew J Harries, Francisco Jimenez, Ander Izeta, Jonathan Hardman, Sreejith Parameswara Panicker, Enrique Poblet, Ralf Paus
Inflammation-associated, irreversible damage to epithelial stem cells (eSCs) of the hair follicle in their immunologically privileged niche lies at the heart of scarring alopecia, which causes permanent difficult-to-treat hair loss. We propose that the two most common and closely related forms, lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA), provide excellent model diseases for studying the biology and pathology of adult human eSCs in an easily accessible human mini-organ. Emphasising the critical roles for interferon (IFN)-γ and peroxisome proliferator-activated receptor (PPAR)-γ-mediated signalling in immune privilege (IP) collapse and epithelial-mesenchymal transition (EMT) of these eSCs respectively, we argue that these pathways deserve therapeutic targeting in the future management of LPP/FFA and other eSC diseases associated with IP collapse and EMT...
April 13, 2018: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/29621642/adipose-derived-stem-cells-improve-full-thickness-skin-grafts-in-a-rat-model
#4
Silvana Bellini Vidor, Paula Barros Terraciano, Fernanda Soldatelli Valente, Verônica Machado Rolim, Cristiana Palma Kuhl, Laura Silveira Ayres, Tuane Nerissa Alves Garcez, Natália Emerim Lemos, Cristiano Ely Kipper, Sabrina Beal Pizzato, David Driemeier, Elizabeth Obino Cirne-Lima, Emerson Antonio Contesini
To investigate the effects of heterologous adipose-derived stem cells (ADSCs) on autologous full-thickness skin grafts, we designed a first-intention healing model using Wistar rats. We harvested and sutured two full-thickness skin grafts in the dorsal recipient beds of 15 rats, randomized into three groups. In the treatment group, 1 × 106 ADSCs resuspended in saline solution (200 μL) were administered subcutaneously to the skin graft. The control group received only saline solution subcutaneously, whereas the negative control group did not receive any treatment...
March 28, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29615568/roles-of-the-hedgehog-signaling-pathway-in-epidermal-and-hair-follicle-development-homeostasis-and-cancer
#5
REVIEW
Yoshinori Abe, Nobuyuki Tanaka
The epidermis is the outermost layer of the skin and provides a protective barrier against environmental insults. It is a rapidly-renewing tissue undergoing constant regeneration, maintained by several types of stem cells. The Hedgehog (HH) signaling pathway is one of the fundamental signaling pathways that contributes to epidermal development, homeostasis, and repair, as well as to hair follicle development and follicle bulge stem cell maintenance. The HH pathway interacts with other signal transduction pathways, including those activated by Wnt, bone morphogenetic protein, platelet-derived growth factor, Notch, and ectodysplasin...
November 20, 2017: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29615452/glutamate-transporter-slc1a3-mediates-inter-niche-stem-cell-activation-during-skin-growth
#6
Bettina Reichenbach, Johanna Classon, Tomomi Aida, Kohichi Tanaka, Maria Genander, Christian Göritz
Tissues contain distinct stem cell niches, but whether cell turnover is coordinated between niches during growth is unknown. Here, we report that in mouse skin, hair growth is accompanied by sebaceous gland and interfollicular epidermis expansion. During hair growth, cells in the bulge and outer root sheath temporarily upregulate the glutamate transporter SLC1A3, and the number of SLC1A3+ basal cells in interfollicular epidermis and sebaceous gland increases. Fate mapping of SLC1A3+ cells in mice revealed transient expression in proliferating stem/progenitor cells in all three niches...
April 3, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29605938/establishment-of-dermal-sheath-cell-line-from-cashmere-goat-and-characterizing-cytokeratin-13-as-its-novel-biomarker
#7
Bing Zhu, Zhili Guo, Muzi Jin, Yujuan Bai, Wenliang Yang, Lihua Hui
OBJECTIVE: To establish a dermal sheath cell line, a dermal papilla cell line and a outer root sheath cell line from Cashmere goat and clarify the similarities and differences among them. RESULTS: We established a dermal sheath cell line, a dermal papilla cell line and a outer root sheath cell line from the pelage skin hair follicles of Cashmere goat. The growth rate of dermal sheath cells was intermediate between that of dermal papilla cells and outer root sheath cells...
March 31, 2018: Biotechnology Letters
https://www.readbyqxmd.com/read/29604146/life-before-and-beyond-blistering-the-role-of-collagen-xvii-in-epidermal-physiology
#8
REVIEW
Ken Natsuga, Mika Watanabe, Wataru Nishie, Hiroshi Shimizu
Type XVII collagen (COL17) is a transmembranous protein that is mainly expressed in the epidermal basal keratinocytes. Epidermal-dermal attachment requires COL17 expression at the hemidesmosomes of the epidermal basement membrane zone because congenital COL17 deficiency leads to junctional epidermolysis bullosa and acquired autoimmunity to COL17 induces bullous pemphigoid. Recently, in addition to facilitating epidermal-dermal attachment, COL17 has been reported to serve as a niche for hair follicle stem cells, to regulate proliferation in the interfollicular epidermis and to be present along the non-hemidesmosomal plasma membrane of epidermal basal keratinocytes...
March 31, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29601620/multi-center-double-blind-vehicle-controlled-clinical-trial-of-an-alpha-and-beta-defensin-containing-anti-aging-skin-care-regimen-with-clinical-histopathologic-immunohistochemical-photographic-and-ultrasound-evaluation
#9
Amy Taub, Vivian Bucay, Gregory Keller, Jay Williams, Darius Mehregan
BACKGROUND/OBJECTIVES: Anti-aging strategies utilizing stem cells are in the forefront. Alpha and beta defensins are natural immune peptides that have been shown to activate an LGR6-positive stem cell locus in the hair follicle, identified as the source of most new epidermal cells during acute wound healing. We investigated the ability of biomimetic alpha and beta defensin molecules, supplemented with supportive cosmetic ingredients, formulated into three skin care products, at improving the structure and function of aging skin...
April 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29584689/extracellular-matrix-as-a-regulator-of-epidermal-stem-cell-fate
#10
REVIEW
Elina Chermnykh, Ekaterina Kalabusheva, Ekaterina Vorotelyak
Epidermal stem cells reside within the specific anatomic location, called niche, which is a microenvironment that interacts with stem cells to regulate their fate. Regulation of many important processes, including maintenance of stem cell quiescence, self-renewal, and homeostasis, as well as the regulation of division and differentiation, are common functions of the stem cell niche. As it was shown in multiple studies, extracellular matrix (ECM) contributes a lot to stem cell niches in various tissues, including that of skin...
March 27, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29582374/isolation-and-cultivation-of-epidermal-stem-cells
#11
Xusheng Wang, Shiyang Dong, Yaojiong Wu
Recent studies have shown that epidermal stem cells derived from the epidermis of are able to form hair follicles in the presence of hair follicle-inducing cells. Here we describe the method that we have used to isolate and cultivate epidermal stem cells.
March 27, 2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29573406/th17-treg-imbalance-in-hidradentitis-suppurativa-acne-inversa-the-link-to-hair-follicle-dissection-obesity-smoking-and-autoimmune-comorbidities
#12
REVIEW
B C Melnik, S M John, W Chen, G Plewig
BACKGROUND: Disintegration of the infundibula of terminal hair follicles (HF) in intertriginous skin areas exhibits the histological hallmark of hidradenitis suppurativa (HS)/acne inversa, featuring a dissecting terminal hair folliculitis. Elevated serum levels of interleukin 17 and local increase in the ratio of proinflammatory Th17 cells and antiinflammatory regulatory T cells (Tregs) have been reported. Perifollicular Tregs play a key role for HF stem cell homeostasis and infundibular integrity...
March 24, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29572803/nerve-growth-and-interaction-in-gelfoam-%C3%A2-histoculture-a-nervous-system-organoid
#13
Robert M Hoffman, Sumiyuki Mii, Jennifer Duong, Yasuyuki Amoh
Nestin-expressing hair follicle-associated pluripotent (HAP) stem cells reside mainly in the bulge area (BA) of the hair follicle but also in the dermal papilla (DP). The BA appears to be origin of HAP stem cells. Long-term Gelfoam® histoculture was established of whiskers isolated from transgenic mice, in which there is nestin-driven green fluorescent protein (ND-GFP). HAP stem cells trafficked from the BA toward the DP area and extensively grew out onto Gelfoam® forming nerve-like structures. These fibers express the neuron marker β-III tubulin-positive fibers and consisted of ND-GFP-expressing cells and extended up to 500 mm from the whisker nerve stump in Gelfoam® histoculture...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29572802/hair-follicle-associated-pluripotent-hap-stem-cells-in-gelfoam-%C3%A2-histoculture-for-use-in-spinal-cord-repair
#14
Fang Liu, Robert M Hoffman
The stem cell marker, nestin, is expressed in the hair follicle, both in cells in the bulge area (BA) and the dermal papilla (DP). Nestin-expressing hair follicle-associated-pluripotent (HAP) stem cells of both the BA and DP have been previously shown to be able to form neurons, heart muscle cells, and other non-follicle cell types. The ability of the nestin-expressing HAP stem cells from the BA and DP to repair spinal cord injury was compared. Nestin-expressing HAP stem cells from both the BA and DP grew very well on Gelfoam® ...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29572801/hair-shaft-growth-in-gelfoam-%C3%A2-histoculture-of-skin-and-isolated-hair-follicles
#15
Robert M Hoffman, Lingna Li, Wenluo Cao
Human scalp skin with abundant hair follicles in various stages of the hair growth cycle was histocultured for up to 40 days on Gelfoam® at the air/liquid interface. The anagen hair follicles within the histoculture scalp skin produced growing hair shafts. Hair follicles could continue their cycle in histoculture; for example, apparent spontaneous catagen induction was observed both histologically and by the actual regression of the hair follicle. In addition, vellus follicles were shown to be viable at day 40 after initiation of culture...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29572789/3d-sponge-matrix-histoculture-an-overview
#16
Robert M Hoffman
Three-dimensional cell culture and tissue culture (histoculture) is much more in vivo-like than 2D culture on plastic. Three-dimensional culture allows investigation of crucial events in tumor biology such as drug response, proliferation and cell cycle progression, cancer cell migration, invasion, metastasis, immune response, and antigen expression that mimic in vivo conditions. Three-dimensional sponge-matrix histoculture maintains the in vivo phenotype, including the formation of differentiated structures of normal and malignant tissues, perhaps due to cells maintaining their natural shape in a sponge-gel matrix such as Gelfoam® ...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29555207/the-force-is-strong-with-this-one-metabolism-over-powers-stem-cell-fate
#17
REVIEW
Peng Wei, Katja K Dove, Claire Bensard, John C Schell, Jared Rutter
Compared to their differentiated progeny, stem cells are often characterized by distinct metabolic landscapes that emphasize anaerobic glycolysis and a lower fraction of mitochondrial carbohydrate oxidation. Until recently, the metabolic program of stem cells had been thought to be a byproduct of the environment, rather than an intrinsic feature determined by the cell itself. However, new studies highlight the impact of metabolic behavior on the maintenance and function of intestinal stem cells and hair follicle stem cells...
March 16, 2018: Trends in Cell Biology
https://www.readbyqxmd.com/read/29554482/transcutaneous-implantation-of-valproic-acid-encapsulated-dissolving-microneedles-induces-hair-regrowth
#18
Shayan Fakhraei Lahiji, Seol Hwa Seo, Suyong Kim, Manita Dangol, Jiyong Shim, Cheng Guo Li, Yonghao Ma, Chisong Lee, Geonwoo Kang, Huisuk Yang, Kang-Yell Choi, Hyungil Jung
The interest in alternative material systems and delivery methods for treatment of androgenetic alopecia has been increasing in the recent decades. Topical application of valproic acid (VPA), an FDA-approved anticonvulsant drug, has been shown to effectively stimulate hair follicle (HF) regrowth by upregulating Wnt/β-catenin, a key pathway involved in initiation of HF development. Moreover, a majority of studies have suggested that cutaneous wound re-epithelialization is capable of inducing HF through Wnt/β-catenin pathway...
June 2018: Biomaterials
https://www.readbyqxmd.com/read/29541960/the-role-of-sox9-in-maintaining-the-characteristics-and-pluripotency-of-arbas-cashmere-goat-hair-follicle-stem-cells
#19
Nimantana He, Zhenguo Dong, Dapeng Tai, Hao Liang, Xudong Guo, Ming Cang, Dongjun Liu
In our previous work, we isolated Arbas Cashmere goat hair follicle stem cells (gHFSCs) and explored the pluripotency. In this study, we investigated the expression and putative role of Sox9 in the gHFSCs. Immunofluorescence staining showed that Sox9 is predominantly expressed in the bulge region of the Arbas Cashmere goat hair follicle, and also positively expressed in both nucleus and cytoplasm of the gHFSCs. When the cells were transfected using Sox9-shRNA, cell growth slowed down and the expression of related genes decreased significantly, cell cycle was abnormal, while the expression of terminal differentiation marker loricrin was markedly increased; cells lost the typical morphology of HFSCs; the mRNA and protein expression of gHFSCs markers and stem cell pluripotency associated factors were all significantly decreased; the expression of Wnt signaling pathway genes LEF1, TCF1,c-Myc were significantly changed...
March 14, 2018: Cytotechnology
https://www.readbyqxmd.com/read/29509988/capsaicin-induces-atopic-dermatitis-like-manifestations-through-dysregulation-of-proteolytic-system-and-alteration-of-filaggrin-processing-in-rats
#20
Sewon Kim, Seung Keun Back, Heung Sik Na, Sun-Ho Kee
Atopic dermatitis (AD) is a complex disease featuring pruritic skin inflammation. Many animal models have been developed. In a rat model, subcutaneous capsaicin injection within 48 hours after birth induces AD-like skin manifestations of dermatitis and scratching behavior 3 weeks after the injection. When 2-4-week-old rats were injected with capsaicin, the lag period was shortened and the severity of skin manifestations was significantly reduced, suggesting influences of postnatal development. Lgr6 is an epidermal stem cell marker that is normally restricted to the isthmus area of hair follicles at postnatal 2 weeks...
March 6, 2018: Experimental Dermatology
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