keyword
MENU ▼
Read by QxMD icon Read
search

hair follicle stem cell

keyword
https://www.readbyqxmd.com/read/27909870/erratum-to-evaluation-of-the-effect-of-nt-3-and-biodegradable-poly-l-lactic-acid-nanofiber-scaffolds-on-differentiation-of-rat-hair-follicle-stem-cells-into-neural-cells-in-vitro
#1
Fatemeh Moghani Ghoroghi, Leila Beygom Hejazian, Banafshe Esmaeilzade, Masumeh Dodel, Masoud Roudbari, Maliheh Nobakht
No abstract text is available yet for this article.
December 1, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27908934/gata6-promotes-hair-follicle-progenitor-cell-renewal-by-genome-maintenance-during-proliferation
#2
Alex B Wang, Ying V Zhang, Tudorita Tumbar
Cell proliferation is essential to rapid tissue growth and repair, but can result in replication-associated genome damage. Here, we implicate the transcription factor Gata6 in adult mouse hair follicle regeneration where it controls the renewal of rapidly proliferating epithelial (matrix) progenitors and hence the extent of production of terminally differentiated lineages. We find that Gata6 protects against DNA damage associated with proliferation, thus preventing cell cycle arrest and apoptosis. Furthermore, we show that in vivo Gata6 stimulates EDA-receptor signaling adaptor Edaradd level and NF-κB pathway activation, known to be important for DNA damage repair and stress response in general and for hair follicle growth in particular...
December 1, 2016: EMBO Journal
https://www.readbyqxmd.com/read/27904857/t-cadherin-expression-in-the-epidermis-and-adnexal-structures-of-normal-skin
#3
Stanislaw Buechner, Paul Erne, Therese J Resink
BACKGROUND: T-cadherin is an atypical glycosylphosphatidylinositol-anchored member of the cadherin superfamily of adhesion molecules. The role of T-cadherin in biology of the skin is poorly understood. Expression of T-cadherin in basal keratinocytes and dermal blood vessels of the healthy epidermis has been demonstrated, but studies on expression in skin appendages are rare. METHODS: We conducted an immunohistochemical analysis of T-cadherin expression in the epidermis and adnexal structures of normal skin...
September 2016: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/27904182/comparative-study-of-efficacy-of-epidermal-melanocyte-transfer-versus-hair-follicular-melanocyte-transfer-in-stable-vitiligo
#4
Navya Donaparthi, Ajay Chopra
BACKGROUND: Vitiligo surgery has come up a long way from punch skin grafts to epidermal cell suspension and latest to the extracted hair follicle outer root sheath cell suspension (EHFORSCS) transplantation. The progressive development from one technique to the other is always on a quest for the best. In the latest development, EHFORSCS, which is an enriched source of follicular inactive melanocyte (melanocyte stem cells), seems to be a good addition to the prevailing cell-based therapies for vitiligo...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27898952/frequency-of-leukochimerism-in-holstein-and-jersey-twinsets
#5
A S Young, B W Kirkpatrick
The current study was conducted to test breed difference in the frequency of leukochimerism. This study used leukochimerism as evidence of placental vascular anastomosis formation and compared its frequency in the Holstein and Jersey breeds. We test the null hypothesis that there is no difference in incidence of leukochimerism in the Holstein and Jersey breeds. Hair and blood samples were collected from 85 Jersey twinsets and 80 Holstein twinsets, ranging in age from 1 d to 8 yr. An additional 7 Holstein twinsets (6 complete and 1 partial where 1 twin died) were sampled originally 48 to 72 h after birth and resampled at 5 to 10 mo of age to provide an assessment of whether leukochimerism changed with age...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898044/dna-damage-inducible-transcript-4-is-an-innate-surveillant-of-hair-follicular-stress-in-vitamin-d-receptor-knockout-mice-and-a-regulator-of-wound-re-epithelialization
#6
Hengguang Zhao, Sandra Rieger, Koichiro Abe, Martin Hewison, Thomas S Lisse
Mice and human patients with impaired vitamin D receptor (VDR) signaling have normal developmental hair growth but display aberrant post-morphogenic hair cycle progression associated with alopecia. In addition, VDR(-/-) mice exhibit impaired cutaneous wound healing. We undertook experiments to determine whether the stress-inducible regulator of energy homeostasis, DNA damage-inducible transcript 4 (Ddit4), is involved in these processes. By analyzing hair cycle activation in vivo, we show that VDR(-/-) mice at day 14 exhibit increased Ddit4 expression within follicular stress compartments...
November 26, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27889319/cell-type-specific-chromatin-states-differentially-prime-squamous-cell-carcinoma-tumor-initiating-cells-for-epithelial-to-mesenchymal-transition
#7
Mathilde Latil, Dany Nassar, Benjamin Beck, Soufiane Boumahdi, Li Wang, Audrey Brisebarre, Christine Dubois, Erwin Nkusi, Sandrine Lenglez, Agnieszka Checinska, Alizée Vercauteren Drubbel, Michael Devos, Wim Declercq, Rui Yi, Cédric Blanpain
Epithelial to mesenchymal transition (EMT) in cancer cells has been associated with metastasis, stemness, and resistance to therapy. Some tumors undergo EMT while others do not, which may reflect intrinsic properties of their cell of origin. However, this possibility is largely unexplored. By targeting the same oncogenic mutations to discrete skin compartments, we show that cell-type-specific chromatin and transcriptional states differentially prime tumors to EMT. Squamous cell carcinomas (SCCs) derived from interfollicular epidermis (IFE) are generally well differentiated, while hair follicle (HF) stem cell-derived SCCs frequently exhibit EMT, efficiently form secondary tumors, and possess increased metastatic potential...
November 16, 2016: Cell Stem Cell
https://www.readbyqxmd.com/read/27882588/clinical-and-epidemiological-analysis-in-149-cases-of-rhododendrol-induced-leukoderma
#8
Momoko Yoshikawa, Yasuyuki Sumikawa, Tokimasa Hida, Takafumi Kamiya, Kimi Kase, Yasue Ishii-Osai, Junji Kato, Yuji Kan, Shiori Kamiya, Yuki Sato, Toshiharu Yamashita
Rhododendrol-induced leukoderma is an acquired depigmentation that develops mainly at the contact site after repeated use of skin-whitening cosmetics containing rhododendrol. In most cases, cessation of further depigmentation or occurrence of repigmentation is observed after discontinuing the use of cosmetics. However, some patients develop vitiligo vulgaris through the spread of depigmentation into the non-exposed areas. Our study aims to investigate the patient-specific factors that may affect the extent of depigmentation or repigmentation, as well as development of vitiligo vulgaris...
November 24, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27880932/lgr6-stem-cells-and-their-progeny-in-mouse-epidermis-under-regimens-of-exogenous-skin-carcinogenesis-and-their-absence-in-ensuing-skin-tumors
#9
Gerline C van de Glind, Heggert G Rebel, Jacoba J Out-Luiting, Wim Zoutman, Cornelis P Tensen, Frank R de Gruijl
Lgr6+ cells have been identified as a novel class of proliferating (Ki67+) stem cells in mouse epidermis. We investigated their response to UV exposure in Lgr6-EGFP-Ires-CreERT2/R26R-LacZ haired and hairless mice and whether they become initiating cells of UV- or chemically induced skin tumors. UV overexposure erased Lgr6+ cells (EGFP+) from the interfollicular epidermis (IFE), but - as after wounding - they apparently repopulated the IFE from the hair follicles. Under sub-sunburn chronic UV exposure, Lgr6+ cells and their progeny (LacZ+ after pulse of tamoxifen) diminished strongly in the IFE...
November 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27880068/human-hair-follicle-associated-pluripotent-hhap-stem-cells-differentiate-to-cardiac-muscle-cells
#10
Natsuko Tohgi, Koya Obara, Masateru Yashiro, Yuko Hamada, Nobuko Arakawa, Sumiyuki Mii, Ryoichi Aki, Robert M Hoffman, Yasuyuki Amoh
We have previously demonstrated that the nestin-expressing hair follicle-associated-pluripotent (HAP) stem cells are located in the bulge area. HAP stem cells have been previously shown to differentiate to neurons, glial cells, keratinocytes, smooth-muscle cells, melanocytes and cardiac-muscle cells in vitro. Subsequently, we demonstrated that HAP stem cells could effect nerve and spinal cord regeneration in mouse models, differentiating to Schwann cells and neurons. In previous studies, we established an efficient protocol for the differentiation of cardiac-muscle cells from mouse HAP stem cells...
November 23, 2016: Cell Cycle
https://www.readbyqxmd.com/read/27867768/induced-pluripotent-stem-cells-from-human-hair-follicle-keratinocytes-as-a-potential-source-for-in-vitro-hair-follicle-cloning
#11
Sheng Jye Lim, Shu Cheow Ho, Pooi Ling Mok, Kian Lee Tan, Alan H K Ong, Seng Chiew Gan
BACKGROUND: Human hair follicles are important for the renewal of new hairs and their development. The generation of induced pluripotent stem cells (iPSCs) from hair follicles is easy due to its accessibility and availability. The pluripotent cells derived from hair follicles not only have a higher tendency to re-differentiate into hair follicles, but are also more suited for growth in hair scalp tissue microenvironment. METHODS: In this study, human hair follicular keratinocytes were used to generate iPSCs, which were then further differentiated in vitro into keratinocytes...
2016: PeerJ
https://www.readbyqxmd.com/read/27862634/expression-analysis-of-the-stem-cell-marker-pw1-peg3-reveals-a-cd34-negative-progenitor-population-in-the-hair-follicle
#12
Vanessa Besson, Sergiy Kyryachenko, Peggy Janich, Salvador A Benitah, Giovanna Marazzi, David Sassoon
Pw1/Peg3 is a parentally imprinted gene expressed in adult stem cells in every tissue thus far examined including the stem cells of the hair follicle. Using a Pw1/Peg3 reporter mouse, we carried out a detailed dissection of the stem cells in the bulge, which is a major stem cell compartment of the hair follicle in mammalian skin. We observed that PW1/Peg3 expression initiates upon placode formation during fetal development, coincident with the establishment of the bulge stem cells. In the adult, we observed that PW1/Peg3 expression is found in both CD34+ and CD34- populations of bulge stem cells...
November 15, 2016: Stem Cells
https://www.readbyqxmd.com/read/27837565/cryopreservation-of-hair-follicle-associated-pluripotent-hap-stem-cells-maintains-differentiation-and-hair-growth-potential
#13
Robert M Hoffman, Satoshi Kajiura, Wenluo Cao, Fang Liu, Yasuyuki Amoh
Hair follicles contain nestin-expressing pluripotent stem cells which originate above the bulge area of the follicle, below the sebaceous gland. We have termed these cells hair follicle-associated pluripotent (HAP) stem cells. We have established efficient cryopreservation methods of the hair follicle that maintain the pluripotency of HAP stem cells as well as hair growth. We cryopreserved the whole hair follicle by slow-rate cooling in TC-Protector medium or in DMSO-containing medium and storage in liquid nitrogen or at -80 °C...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27837456/cycling-cd34-expression-in-subpopulations-of-head-and-neck-squamous-cell-carcinoma-cell-lines-is-involved-in-radioresistance-and-change-in-cytokeratin-expression-profile
#14
Tobias Ettl, Matthias Hautmann, Torsten E Reichert, Richard Bauer
The expression of the hair follicle stem cell marker CD34 was analyzed in five different head and neck squamous cell carcinoma (HNSCC) cell lines with different antibodies. All HNSCC cell lines expressed CD34 on their cell surface. After cell cycle synchronization via serum starvation, we observed cyclic CD34 expression in HNSCC cells dependent on cell cycle progression via immunofluorescent staining and flow cytometric analysis. Investigation of the CD34(+) and CD34(-) HNSCC populations revealed most of the cells in S-phase and G2/M-Phase in CD34(+) cells in contrast to CD34(-) cells...
November 11, 2016: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/27831564/skin-derived-stem-cells-as-a-source-of-primordial-germ-cell-and-oocyte-like-cells
#15
REVIEW
Wei Ge, Shun-Feng Cheng, Paul W Dyce, Massimo De Felici, Wei Shen
The skin is a unique organ that contains a variety of stem cells for the maintenance of skin homeostasis and the repair of skin tissues following injury and disease. Skin-derived stem cells (SDSCs) constitute a heterogeneous population of stem cells generated in vitro from dermis, which can be cultured as spherical aggregates of cells in suspension culture. Under certain in vitro or in vivo conditions, SDSCs show multipotency and can generate a variety of neural, mesodermal, and endodermal cell types such as neurons, glia, fibroblasts, adipocytes, muscle cells, chondroblasts, osteoblats, and islet β-cell-like cells...
November 10, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27828841/the-histocompatibility-research-of-hair-follicle-stem-cells-with-bladder-acellular-matrix
#16
Jia Li, Wenguang Wang, Jiuzhi Li, Mulati Rexiati, Henqing An, Feng Wang, Yujie Wang
BACKGROUND: Hair follicle stem cells (HFSCs) were reported to have multidirectional differentiation ability and could be differentiated into melanocytes, keratin cells, smooth muscle cells, and neurons. However, the functionality of HFSCs in bladder tissue regeneration is unknown. METHODS: This study was conducted to build HFSCs vs bladder acellular matrix (BAM) complexes (HFSCs-BAM complexes) in vitro and evaluated whether HFSCs have well biocompatibility with BAM...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27797819/bimodal-behaviour-of-interfollicular-epidermal-progenitors-regulated-by-hair-follicle-position-and-cycling
#17
Edwige Roy, Zoltan Neufeld, Luca Cerone, Ho Yi Wong, Samantha Hodgson, Jean Livet, Kiarash Khosrotehrani
Interfollicular epidermal (IFE) homeostasis is a major physiological process allowing maintenance of the skin barrier function. Despite progress in our understanding of stem cell populations in different hair follicle compartments, cellular mechanisms of IFE maintenance, in particular, whether a hierarchy of progenitors exists within this compartment, have remained controversial. We here used multicolour lineage tracing with Brainbow transgenic labels activated in the epidermis to track individual keratinocyte clones...
October 21, 2016: EMBO Journal
https://www.readbyqxmd.com/read/27772548/jak-stat-signaling-jump-starts-the-hair-cycle
#18
Etienne Wang, Sivan Harel, Angela M Christiano
Legrand et al show that JAK/STAT5 signaling in the dermal papilla is required for anagen onset in the murine hair cycle. Interestingly, others have shown that JAK-inhibition is able to induce telogen-to-anagen transition in wild-type mice. This apparent contradiction highlights the complexity of interactions within the hair follicle, and encourages further discussion on the role of JAK-STAT signaling in the various stem cell niches of the hair follicle.
November 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27769713/androgens-modify-wnt-agonists-antagonists-expression-balance-in-dermal-papilla-cells-preventing-hair-follicle-stem-cell-differentiation-in-androgenetic-alopecia
#19
Gustavo José Leirós, Julieta María Ceruti, María Lía Castellanos, Ana Gabriela Kusinsky, María Eugenia Balañá
In androgenetic alopecia, androgens impair dermal papilla-induced hair follicle stem cell (HFSC) differentiation inhibiting Wnt signaling. Wnt agonists/antagonists balance was analyzed after dihydrotestosterone (DHT) stimulation in androgen-sensitive dermal papilla cells (DPC) cultured as spheroids or monolayer. In both culture conditions, DHT stimulation downregulated Wnt5a and Wnt10b mRNA while the Wnt antagonist Dkk-1 was upregulated. Notably, tissue architecture of DPC-spheroids lowers Dkk-1 and enhances Wnt agonists' basal expression; probably contributing to DPC inductivity...
October 18, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27766026/immunohistochemical-study-of-hair-follicle-stem-cells-in-regenerated-hair-follicles-induced-by-wnt10b
#20
Yiming Zhang, Yizhan Xing, Haiying Guo, Xiaogen Ma, Yuhong Li
The regulation of the periodic regeneration of hair follicles is complicated. Although Wnt10b has been reported to induce hair follicle regeneration, the characteristics of induced hair follicles, especially the target cells of Wnt10b, have not yet been clearly elucidated. Thus, we systematically evaluated the expression and proliferation patterns of Wnt10b-induced hair follicles. We found that Wnt10b promoted the proliferation of hair follicle stem cells from 24 hours after AdWnt10b injection. Seventy-two hours after AdWnt10b injection, cells outside of bulge area began to proliferate...
2016: International Journal of Medical Sciences
keyword
keyword
95916
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"