keyword
MENU ▼
Read by QxMD icon Read
search

caspase 8

keyword
https://www.readbyqxmd.com/read/29475156/potent-hydrazone-derivatives-targeting-esophageal-cancer-cells
#1
Ling-Yu Li, Jia-Di Peng, Wenjuan Zhou, Hui Qiao, Xin Deng, Zhou-Hua Li, Ji-Deng Li, Yun-Dong Fu, Song Li, Kai Sun, Hong-Min Liu, Wen Zhao
Hydrazone and their derivatives are a series of highly active molecules, which are widely used as lead compounds for the research and development of new anti-cancer drugs. In this study, 20 compounds were synthesized, based on this scaffold and their in vitro cytotoxicity against 6 cancer cell lines, including EC9706, SMMC-7721, MCF7, PC3, MGC-803 and EC109 was tested. Among them, compound 6p, showed strong anti-proliferative activities on esophageal carcinoma cells: EC9706 and EC109 with IC50 values of 1...
February 14, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29474123/neuroprotective-effects-of-the-methanol-extract-of-kimchi-a-korean-fermented-vegetable-food-mediated-via-suppression-of-endoplasmic-reticulum-stress-and-caspase-cascade-pathways-in-high-cholesterol-diet-fed-mice
#2
Serim Kim, Minji Woo, Mijeong Kim, Jeong Sook Noh, Yeong Ok Song
Endoplasmic reticulum (ER) stress-related unfolded peptide accumulation is closely associated with the development of neurodegenerative diseases known as protein misfolding disorders. The antioxidative properties of kimchi, a traditional Korean fermented vegetable dish, have been well established. In this study, the neuroprotective effects of the kimchi methanol extract (KME) were examined in high-cholesterol diet (HCD)-fed mice. The animals were fed a HCD, with oral administration of either KME (KME group, 200 mg·kg bw-1 ·day-1 , n = 10) or distilled water (Control group, n = 10) for 8 weeks...
February 23, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29470982/rip3-deficiency-protects-against-traumatic-brain-injury-tbi-through-suppressing-oxidative-stress-inflammation-and-apoptosis-dependent-on-ampk-pathway
#3
Zai-Ming Liu, Qian-Xue Chen, Zhi-Biao Chen, Dao-Feng Tian, Ming-Chang Li, Jun-Min Wang, Long Wang, Bao-Hui Liu, Shen-Qi Zhang, Fei Li, Hui Ye, Long Zhou
Traumatic brain injury (TBI) is a leading cause of disability and mortality in young adults worldwide. The pathophysiology is not fully understood. Programmed necrosis (necroptosis) is a newly identified mechanism of cell death combining features of both apoptosis and necrosis. Receptor-interacting protein 3 (RIP3) plays an important role in programmed necrosis. However, the effect of RIP3-related pathway in TBI is little to be known. We attempted to explore the significance of RIP3 in regulating TBI in vivo...
February 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29470550/the-pregnane-x-receptor-pxr-and-the-nuclear-receptor-corepressor-2-ncor2-modulate-cell-growth-in-head-and-neck-squamous-cell-carcinoma
#4
Juan Pablo Rigalli, Matthias Reichel, Tasmin Reuter, Guillermo Nicolás Tocchetti, Gerhard Dyckhoff, Christel Herold-Mende, Dirk Theile, Johanna Weiss
Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent cancer worldwide. The pregnane X receptor (PXR) is a nuclear receptor regulating several target genes associated with cancer malignancy. We here demonstrated a significant effect of PXR on HNSCC cell growth, as evidenced in PXR knock-down experiments. PXR transcriptional activity is more importantly regulated by the presence of coactivators and corepressors than by PXR protein expression. To date, there is scarce information on the regulation of PXR in HNSCC and on its role in the pathogenesis of this disease...
2018: PloS One
https://www.readbyqxmd.com/read/29468482/epirubicin-induces-apoptosis-in-osteoblasts-through-death-receptor-and-mitochondrial-pathways
#5
Tzu-Ching Huang, Pu-Rong Chiu, Wen-Tsan Chang, Bau-Shan Hsieh, Yu-Ci Huang, Hsiao-Ling Cheng, Li-Wen Huang, Yu-Chen Hu, Kee-Lung Chang
Epirubicin is an anthracycline and is widely used in tumor treatment, but has toxic and undesirable side effects on wide range of cells and hematopoietic stem cells (HSC). Osteoblasts play important roles in bone development and in supporting HSC differentiation and maturation. It remains unknown whether epirubicin-induced bone loss and hematological toxicity are associated with its effect on osteoblasts. In primary osteoblast cell cultures, epirubicin inhibited cell growth and decreased mineralization. Moreover, epirubicin arrested osteoblasts in the G2/M phase, and this arrest was followed by apoptosis in which both the extrinsic (death receptor-mediated) and intrinsic (mitochondrial-mediated) apoptotic pathways were evoked...
February 21, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/29467906/%C3%AE-elemene-enhances-anticancer-and-anti-metastatic-effects-of-osteosarcoma-of-ligustrazine-in-vitro-and-in-vivo
#6
Min Fang, Xiaolong Mei, Hui Yao, Tao Zhang, Tao Zhang, Na Lu, Yanshi Liu, Wenyue Xu, Chunyou Wan
The present study aimed to determine the anticancer effects of the combination of β-elemene and ligustrazine in vitro as well as in in vivo . Following evaluation using an MTT assay, β-elemene, ligustrazine and the β-elemene-ligustrazine combination treatments all exhibited the capacity to inhibit the growth of OS-732 cells, with inhibitory rates of 43.3, 54.4, and 75.0%, respectively. Using a flow cytometry assay, it was determined that the β-elemene-ligustrazine combination possessed the highest apoptotic rate (30...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467874/effects-of-nob1-on-the-pathogenesis-of-osteosarcoma-and-its-expression-on-the-chemosensitivity-to-cisplatin
#7
Leiming Luo, Yuanhui Wang, Yiran Yin, Jianhua Ge, Xiaobo Lu
The effects of NIN1/RPN12 binding protein 1 homolog (NOB1) on the pathogenesis of osteosarcoma and its expression on the chemosensitivity to cisplatin were investigated. Seventy-four patients with osteosarcoma who received surgical resection in The Affiliated Hospital of Southwest Medical University (Sichuan, China) from September 2013 to September 2016 were enrolled in this study. The expression of NOB1 in cancer and cancer-adjacent tissues of patients was detected by reverse transcription-polymerase chain reaction, and the relationship between NOB1 expression and the pathogenesis of osteosarcoma was analyzed...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467593/depletion-of-membrane-cholesterol-compromised-caspase-8-imparts-in-autophagy-induction-and-inhibition-of-cell-migration-in-cancer-cells
#8
Mukesh Kumar, Karuna Irungbam, Meena Kataria
Background: Cholesterol in lipid raft plays crucial role on cancer cell survival during metastasis of cancer cells. Cancer cells are reported to enrich cholesterol in lipid raft which make them more susceptible to cell death after cholesterol depletion than normal cells. Methyl-β-cyclodextrin (MβCD), an amphipathic polysaccharide known to deplete the membrane cholesterol, induces cell death selectively in cancer cells. Present work was designed to identify the major form of programmed cell death in membrane cholesterol depleted cancer cells (MDA-MB 231 and 4T1) and its impact on migration efficiency of cancer cells...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29466287/comparison-of-inhibitory-capacities-of-6-8-and-10-gingerols-shogaols-on-the-canonical-nlrp3-inflammasome-mediated-il-1%C3%AE-secretion
#9
Su-Chen Ho, Yi-Huang Chang
Endogenous noninfectious substances that mediate the nucleotide oligomerization domain (NOD)-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation and interleukin (IL)-1β secretion causes inappropriate sterile inflammation and is implicated in the pathogenesis of several chronic diseases, such as type 2 diabetes mellitus, gout, atherosclerosis and Alzheimer's disease. Consequently, dietary phytochemicals exhibiting capacities to suppress canonical NLRP3 inflammasome-mediated IL-1β secretion can be a reliable supplement to prevent such diseases...
February 21, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29464799/antiproliferative-activity-and-apoptosis-induction-by-trijuganone-c-isolated-from-the-root-of-salvia-miltiorrhiza-bunge-danshen
#10
Takuhiro Uto, Nguyen Huu Tung, Tomoe Ohta, Wipawee Juengsanguanpornsuk, Le Quoc Hung, Nguyen Thanh Hai, Dinh Doan Long, Phuong Thien Thuong, Shinya Okubo, Sakiko Hirata, Yukihiro Shoyama
In this study, we found that the hexane fraction of Danshen, the dried root of Salvia miltiorrhiza (Lamiaceae), exerted antiproliferative effects on human leukemia cells. Phytochemical investigation of the hexane fraction achieved the isolation of the tanshinone diterpenes: dihydrotanshinone I (1), trijuganone C (2), trijuganone B (3), cryptotanshinone (4), tanshinone IIA (5), and tanshinone I (6). Compound 2 showed significant antiproliferative activities against human leukemia cells HL-60, Jurkat, and U937...
February 21, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29464796/drug-like-dietary-vanilloids-induce-anticancer-activity-through-proliferation-inhibition-and-regulation-of-bcl-related-apoptotic-proteins
#11
Chun-Wai Mai, Yew-Beng Kang, Vishna Devi Nadarajah, Ahmad Sazali Hamzah, Mallikarjuna Rao Pichika
In this study, a series of 20 structurally similar vanilloids (Vn) were tested for their antiproliferative effects against 12 human cancer cells: human breast (MCF-7 and MDA-MB-231), cervical (HeLa), ovarian (Caov-3), lung (A549), liver (HepG2), colorectal (HT-29 and HCT116), nasopharyngeal (CNE-1 and HK-1), and leukemic (K562 and CEM-SS) cancer cells. Among all the tested vanilloids, Vn16 (6-shogaol) exhibited the most potent cytotoxic effects against human colorectal cancer cells (HT-29). The apoptotic induction effects exhibited by Vn16 on HT-29 cells were confirmed using dual staining fluorescence microscopy and enzyme-linked immunosorbent assay...
February 21, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29464048/src-is-the-primary-target-of-aripiprazole-an-atypical-antipsychotic-drug-in-its-anti-tumor-action
#12
Mi Seon Kim, Byong Chul Yoo, Woo Seok Yang, Sang Yun Han, Deok Jeong, Jun Min Song, Kyung Hee Kim, Adithan Aravinthan, Ji Hye Kim, Jong-Hoon Kim, Seung Cheol Kim, Jae Youl Cho
Aripiprazole (ARP) is an atypical anti-psychotic drug widely used to treat schizophrenia and bipolar disorder. The pharmacological effects of ARP on cancer cells are still poorly understood. In this study, anti-cancer effects of ARP on various malignant tumor cells and its molecular mechanism were further carefully examined by using cell proliferation assay, xenograft mouse model, immunoblotting analysis, migration assay, luciferase reporter gene assay, kinase assay, and overexpression strategy. Treatment with ARP induced cytotoxicity in U251 glioma cells, MKN-1 gastric adenosquamous carcinoma cells, and CT26 colon carcinoma cells...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29463225/glycolysis-is-essential-for-chemoresistance-induced-by-transient-receptor-potential-channel-c5-in-colorectal-cancer
#13
Teng Wang, Kuan Ning, Xu Sun, Chun Zhang, Lin-Fang Jin, Dong Hua
BACKGROUND: Elevated intracellular Ca2+ ([Ca2+ ]i ) level could lead to [Ca2+ ]i overload and promote apoptosis via different pathways. In our previously study, up-regulated expression of transient receptor potential canonical channel (TRPC5) was proven to increase [Ca2+ ]i level, and resulted in chemoresistance whereas not apoptosis in human colorectal cancer (CRC) cells. The ATP-dependent homeostatic maintenance of resting [Ca2+ ]i should be important in this process. Increased glycolysis was found to be an important adenosine triphosphate (ATP) source in cancer...
February 20, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29463188/progesterone-inhibits-apoptosis-in-fetal-membranes-by-altering-expression-of-both-pro-and-antiapoptotic-proteins
#14
Yuguang Wang, Vikki M Abrahams, Guoyang Luo, Nicholas G Norwitz, Victoria V Snegovskikh, Shu-Wing Ng, Errol R Norwitz
OBJECTIVE: Progesterone supplementation prevents preterm birth (PTB) in some high-risk women, but its mechanism of action is unknown. One-third of PTB is associated with preterm premature rupture of membranes (PPROMs). We have previously shown that progesterone inhibits basal and Tumor Necrosis Factor (TNF) α-induced apoptosis in an explant model of human fetal membranes. This study investigates the molecular mechanisms responsible for progesterone-mediated inhibition of apoptosis in fetal membranes...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29460253/neuronal-apoptosis-in-the-brainstem-medulla-of-sudden-unexpected-death-in-infancy-sudi-and-the-importance-of-standardized-sudi-classification
#15
Natalie Ambrose, Karen A Waters, Michael L Rodriguez, Kendall Bailey, Rita Machaalani
The purpose of this study was to examine the neuronal expression of apoptotic markers in the rostral medulla of a newly characterized dataset of sudden unexpected death in infancy (SUDI), and to determine the impact of diagnostic groupings on these findings and whether they pertain to the intrinsic apoptotic pathway. Immunohistochemical staining was quantified to determine the percentage of neurons positive for active caspase-9 (specific to the intrinsic apoptotic pathway), active caspase-3 (common to the intrinsic and extrinsic apoptotic pathways) and Terminal deoxynucleotidyl transferase mediated dUTP nick-end labelling (TUNEL) (labels DNA fragmentation) in nine nuclei of the rostral medulla...
February 19, 2018: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29459174/efldo-induces-apoptosis-in-hepatic-cancer-cells-by-caspase-activation-in-vitro-and-suppresses-tumor-growth-in-vivo
#16
Yan-Bo Qu, Zhi-Xin Liao, Chao Liu, Xin-Zhu Wang, Jing Zhang
To study the apoptosis induced by EFLDO (ent-3α-formylabieta-8(14), 13(15)-dien-16,12β-olide), extracted from the Euphorbia lunulata Bge, in the HepG2 cell line and to study the antitumor activity of this compound in vivo, Cell viability and migration were evaluated with CCK-8 (2-(2-methoxy-4-nitrophenyl)-3- (4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium, monosodium salt) and wound healing assays, respectively. In addition, the cell cycle was examined using flow cytometry after propidium iodide (PI) staining...
February 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29458164/structure-dependent-induction-of-apoptosis-by-hepatotoxic-pyrrolizidine-alkaloids-in-the-human-hepatoma-cell-line-heparg-single-versus-repeated-exposure
#17
Julia Waizenegger, Albert Braeuning, Markus Templin, Alfonso Lampen, Stefanie Hessel-Pras
Pyrrolizidine alkaloids (PA) are secondary plant compounds. PA intoxication in humans causes severe acute and chronic hepatotoxicity. However, the molecular mechanisms of PA hepatotoxicity in humans are not well understood yet. Therefore, we investigated cell death parameters in human HepaRG cells following either single (24 h) or repeated dose treatment (14 d) with structurally different PA of the retronecine (echimidine, senecionine), heliotridine (heliotrine), and otonecine type (senkirkine). After 24 h of exposure only retronecine-type PA were cytotoxic in HepaRG cells and induced apoptosis indicated by a loss of membrane asymmetry, disruption of the mitochondrial membrane potential, and increased pro-caspase and PARP cleavage...
February 16, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29456821/resveratrol-decreases-apoptosis-and-nlrp3-complex-expressions-in-experimental-varicocele-rat-model
#18
Elnaz Hajipour, Farideh Jalali Mashayekhi, Ghasem Mosayebi, Maryam Baazm, Adib Zendedel
Objectives: Varicocele is an abnormal dilation in the testicular vein, which can cause hypoxia, reactive oxygen species accumulation, elevation in testicular temperature, and promote apoptosis and increase proinflammatory cytokine production. According to the varicocele pathophysiology, it is possible that a group of cytosolic receptors called nucleotide oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasomes also involve in varicocele pathogenesis...
February 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29456809/hypericin-photodynamic-therapy-inhibits-proliferation-and-induces-apoptosis-in-human-rheumatoid-arthritis-fibroblast-like-synoviocytes-cell-line-mh7a
#19
Kun Zhang, Shan Gao, JiaYi Guo, GuoHua Ni, Zhe Chen, Feng Li, XiaoLei Zhu, YongBing Wen, YanXing Guo
Objectives: To elucidate the effects and potential mechanisms of hypericin-photodynamic therapy (HYP-PDT) for treating the human rheumatoid arthritis (RA) fibroblast-like synoviocyte (FLS) MH7A cell-line. Materials and Methods: MH7A cells were subjected to HYP-PDT intervention and apoptosis was evaluated via MTT, nuclear staining, and flowcytometry analyses. Intracellular reactive oxygen species (ROS) were measured with the fluorescent probe 2'7'-dichlorofluorescein diacetate (DCFH-DA)...
February 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29456668/fpoa-induces-the-apoptosis-of-hepg2-cells
#20
Mingjie Song, Haiying Bao, Tolgor Bau
The triterpenoid 3-acetoxylanosta-8,24-dien-21-oic acid (FPOA) is isolated from the fruiting body of Fomitopsis pinicola . The present study reports that FPOA exerts cytotoxic activity and describes the molecular mechanism of FPOA-induced apoptosis on human HepG2 hepatoma cells. FPOA exhibited significant cytotoxic effects against HepG2, MCF-7 and HeLa cells. However, FPOA was particularly cytotoxic towards HepG2 cells, with a half maximal inhibitory concentration value of 42.10 µM, thus these cells were taken forward for further analysis...
March 2018: Experimental and Therapeutic Medicine
keyword
keyword
95915
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"