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https://www.readbyqxmd.com/read/29053994/dietary-resveratrol-confers-apoptotic-resistance-to-oxidative-stress-in-myoblasts
#1
Satoshi Haramizu, Shinichi Asano, David C Butler, David A Stanton, Ameena Hajira, Junaith S Mohamed, Stephen E Alway
High levels of reactive oxygen species (ROS) contribute to muscle cell death in aging and disuse. We have previously found that resveratrol can reduce oxidative stress in response to aging and hindlimb unloading in rodents in vivo, but it was not known if resveratrol would protect muscle stem cells during repair or regeneration when oxidative stress is high. To test the protective role of resveratrol on muscle stem cells directly, we treated the C2C12 mouse myoblast cell line with moderate (100 μM) or very high (1 mM) levels of H2O2 in the presence or absence of resveratrol...
August 24, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29050480/the-effect-of-leptin-and-resveratrol-on-jak-stat-pathways-and-sirt-1-gene-expression-in-the-renal-tissue-of-ischemia-reperfusion-induced-rats
#2
S Erkasap, N Erkasap, B Bradford, L Mamedova, O Uysal, M Ozkurt, R Ozyurt, O Kutlay, B Bayram
OBJECTIVE: Our study aimed to investigate the possible modifying effects of leptin and combined use of resveratrol on rat renal I/R injury and their relationship on signal pathways and apoptosis-related mechanisms. BACKGROUND: Renal ischemia-reperfusion (I/R) injury is an important cause of acute renal failure. METHODS: Male Sprague Dawley rats were divided into 5 groups: Control, I/R, I/R+leptin, I/R+resveratrol and I/R+leptin+resveratrol...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29049999/luteolin-promotes-cell-apoptosis-by-inducing-autophagy-in-hepatocellular-carcinoma
#3
Zhijia Cao, Huainian Zhang, Xiaoyan Cai, Wei Fang, Dong Chai, Ying Wen, Hongsheng Chen, Fujiang Chu, Yongli Zhang
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is a leading cause of cancer-related death worldwide. Luteolin, a flavonoid from traditional Chinese medicine, shows anti-cancer activity in many cancer cells, including HCC. However, the mechanism underlying the action of luteolin in HCC, especially its role in regulating cell autophagy, remains unclear. In the present study, we investigated the role of luteolin in regulating cell autophagy and the role of autophagy in luteolin-induced apoptosis...
October 19, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29048755/nifedipine-prevents-apoptosis-of-alcohol-exposed-first-trimester-trophoblast-cells
#4
Alan D Bolnick, Jay M Bolnick, Hamid-Reza Kohan-Ghadr, Brian A Kilburn, Michael Hertz, Jing Dai, Sascha Drewlo, D Randall Armant
BACKGROUND: Maternal alcohol abuse leading to fetal alcohol spectrum disorder (FASD) includes fetal growth restriction (FGR). Ethanol induces apoptosis of human placental trophoblast cells, possibly disrupting placentation and contributing to FGR in FASD. Ethanol facilitates apoptosis in several embryonic tissues, including human trophoblasts, by raising intracellular Ca(2+) . We previously found that acute ethanol exposure increases trophoblast apoptosis due to signaling from both intracellular and extracellular Ca(2+) ...
October 19, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29048685/mir-504-promotes-tumour-growth-and-metastasis-in-human-osteosarcoma-by-targeting-tp53inp1
#5
Qingchun Cai, Sixiang Zeng, Xing Dai, Junlong Wu, Wei Ma
An increasing number of studies have demonstrated that microRNAs participate in the development of osteosarcoma by acting as tumour suppressor or tumour-promoting genes. We investigated the role of miR-504 in the growth and metastasis of osteosarcoma. The expression of miR-504 in clinical osteosarcoma samples was higher than that in the adjacent normal tissue and correlated with tumour size and clinical stage. Tumour protein p53-inducible nuclear protein 1 (TP53INP1) was downregulated in the clinical osteosarcoma samples compared with the adjacent normal tissues and was consistently correlated with the clinical stage...
September 21, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29048676/decreased-expression-of-the-augmenter-of-liver-regeneration-results-in-growth-inhibition-and-increased-chemosensitivity-of-acute-t-lymphoblastic-leukemia-cells
#6
Yan Shen, Qi Liu, Shifeng Lou, Yun Luo, Hang Sun, Hanqing Zeng, Jianchuan Deng
Augmenter of liver regeneration (ALR) plays crucial roles in cell survival and growth. Previous studies have demonstrated that ALR exerts a protective effect on toxic agent‑induced cell death in acute T lymphoblastic leukemia cells and ALR knockdown can sensitize cancer cells to radiation. However, the biological functions of ALR against drug resistance in T-cell acute lymphoblastic leukemia are mostly unknown. In the present study, we investigated the effect of small interfering RNA (siRNA)-induced ALR silencing on cell proliferation and sensitivity to vincristine (VCR) of Jurkat cells...
September 21, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29048645/establishment-and-characterization-of-human-osteosarcoma-cells-resistant-to-pyropheophorbide-%C3%AE-methyl-ester-mediated-photodynamic-therapy
#7
Yong Tao, Yunsheng Ou, Hang Yin, Yanyang Chen, Shenxi Zhong, Yongjian Gao, Zenghui Zhao, Bin He, Qiu Huang, Qianxing Deng
The present study was performed to establish and characterize new human osteosarcoma cell lines resistant to pyropheophorbide-α methyl ester‑mediated photodynamic therapy (MPPa-PDT). MPPa-PDT-resistant cells are isolated from the human osteosarcoma MG63 and HOS cell lines and two resistant populations were finally acquired, including MG63/PDT and HOS/PDT. Cell Counting Kit-8 (CCK-8) assay was used to determine the MPPa-PDT, cisplatin (CDDP) resistance and proliferation of MG63, MG63/PDT, HOS and HOS/PDT cells...
September 27, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29048633/in%C3%A2-vitro-and-in%C3%A2-vivo-anti-primary-effusion-lymphoma-activities-of-fucoidan-extracted-from-cladosiphon-okamuranus-tokida
#8
Chie Ishikawa, Naoki Mori
Primary effusion lymphoma (PEL) caused by Kaposi's sarcoma-associated herpesvirus (KSHV) is characterized by lymphomatous effusion in body cavities and poor prognosis. There is still no effective treatment for PEL. Fucoidan, a major sulfated polysaccharide isolated from brown seaweeds, has an attractive array of bioactivities such as cancer inhibition. However, the effects of fucoidan on PEL cells remain unclear. We investigated the anti-PEL effects of fucoidan obtained from Cladosiphon okamuranus Tokida cultivated in Okinawa...
September 20, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29048624/liquiritin-induces-apoptosis-and-autophagy-in-cisplatin-ddp-resistant-gastric-cancer-cells-in-vitro-and-xenograft-nude-mice-in-vivo
#9
Feng Wei, Xin Jiang, Hao-Yue Gao, Shuo-Hui Gao
Gastric cancer is reported as one of the leading factors resulting in tumor-related death worldwide. However, the therapies to suppress gastric cancer are still limited and the emergence of drug resistance makes it necessary to develop new and effective anticancer drugs and combinational chemotherapy schemes. Liquiritin (LIQ) is a major constituent of Glycyrrhiza Radix, exhibiting various pharmacological activities, including anticancer. In this study, we investigated the role of LIQ in human gastric cancer cells with cisplatin (DDP) resistance...
September 22, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29047155/maduramicin-induces-apoptosis-and-necrosis-and-blocks-autophagic-flux-in-myocardial-h9c2-cells
#10
Xin Chen, Long Chen, Shanxiang Jiang, Shile Huang
Maduramicin, a polyether ionophore antibiotic, is widely used as an anticoccidial agent in the poultry industry. It has been reported that maduramicin may cause heart and skeletal muscle cell damage, resulting in heart failure, skeletal muscle degeneration and even death in animals and humans, if improperly used. However, the molecular mechanism behind its capability to cause death of cardiac cells is not known. Here, we show that maduramicin induced apoptosis and necrosis in rat myocardial cells (H9c2). Maduramicin did not apparently upregulate the expression of pro-apoptotic proteins (e...
October 19, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29046047/apoptosis-pattern-and-alterations-of-expression-of-apoptosis-related-factors-of-supporting-cells-in-k%C3%A3-lliker-s-organ-in-vivo-in-early-stage-after-birth-in-rats
#11
Jun Liu, Linbin Cai, Yuanyuan He, Jun Yang
Kölliker's organ is a temporary but indispensable structure in the development of the cochlea. Supporting cells (SCs) within it release adenosine 5'-triphosphate (ATP), which may play a crucial role in cochlear development before the onset of hearing. To reveal the apoptosis of Kölliker's organ in new-born rats, we studied the morphological changes and expression of apoptosis-related factors during early postnatal development. We found SCs in Kölliker's organ decreased in number and changed in appearance along the cochlea apex-to-base gradient, and the expression of caspase-3, caspase-8, caspase-9 and bcl-2 in Kölliker's organ of the cochlea fluctuated along the course of postnatal development, with an expression peak at postnatal day 3...
August 7, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/29045447/protective-effect-of-low-dose-risedronate-against-osteocyte-apoptosis-and-bone-loss-in-ovariectomized-rats
#12
Tingjun Ye, Peng Cao, Jin Qi, Qi Zhou, D Sudhaker Rao, Shijing Qiu
Osteocyte apoptosis is the first reaction to estrogen depletion, thereby stimulating osteoclastic bone resorption resulting in bone loss. We investigated the effects of two different risedronate (RIS) doses (high and low) on osteocyte apoptosis, osteoclast activity and bone loss in ovariectomized rats. Forty rats with ovariectomy (OVX) and sham ovariectomy (SHAM) were divided into 4 groups: 1) SHAM rats treated with saline (SHAM); 2) OVX rats treated with saline (OVX); 3) OVX rats treated with low-dose RIS (OVX-LR, 0...
2017: PloS One
https://www.readbyqxmd.com/read/29043662/stryphnodendron-adstringens-barbatim%C3%A3-o-leaf-fraction-chemical-characterization-antioxidant-activity-and-cytotoxicity-towards-human-breast-cancer-cell-lines
#13
A P L Sabino, L M S Eustáquio, A C F Miranda, C Biojone, T N Mariosa, Cibele Marli Cação Paiva Gouvêa
We evaluated the chemical composition, antioxidant activity, and antitumor potential of a fraction that was isolated from Stryphnodendron adstringens (barbatimão) leaf aqueous extract. Fraction is composed by gallic acid, procyanidin dimer B1, and (-)-epicatechin-3-O-gallate and it exhibits antioxidant and cytotoxic activities. Fraction was cytotoxic against two human breast cancer cell lines, ER (+) and MCF-7 and the triple-negative, MDA-MB-435. The sulforhodamine B assay showed that, as compared to normal control cells, the fraction significantly (P < 0...
October 17, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29042944/pien-tze-huang-induces-apoptosis-and-inhibits-proliferation-of-5-fluorouracil-resistant-colorectal-carcinoma-cells-via-increasing-mir-22-expression
#14
Zhaorong Chen, Aling Shen, Liya Liu, Youqin Chen, Jianfeng Chu, Qiaoyan Cai, Fei Qi, Thomas Joseph Sferra, Jun Peng
The well-known traditional Chinese medicine formula Pien Tze Huang (PZH) has long been used to treat various malignancies, including colorectal cancer (CRC). It was recently reported that PZH possesses the ability to overcome multidrug resistance in CRC cells. In the present study, a 5-fluorouracil (5-FU) resistant human CRC cell line (HCT-8/5-FU) was used to further evaluate the effect of PZH on chemotherapy (chemo)-resistance and investigate the mechanisms through which this occurs. The results identified that PZH significantly reduced the viability and cell density of HCT-8/5-FU cells in a dose- and time-dependent manner (P<0...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29040674/evaluation-of-apoptotic-and-autophagic-related-protein-expressions-before-and-after-in-vitro-maturation-of-fresh-slow-frozen-and-vitrified-pre-pubertal-mouse-testicular-tissue
#15
L Dumont, F Chalmel, A Oblette, B Berby, A Rives, V Duchesne, C Rondanino, N Rives
STUDY QUESTION: Do freezing and in vitro culture procedures enhance the expression of proteins involved in apoptotic or autophagic pathways in murine pre-pubertal testicular tissue? SUMMARY ANSWER: In vitro maturation strongly modified apoptosis- and autophagy-related relative protein levels in mice testicular tissue whereas the impact of cryopreservation procedures was minimal at the end of the culture. WHAT IS KNOWN ALREADY: In vitro spermatogenesis remains a challenging technical issue as it imposes to find a very close balance between survival and death of germ cell natural precursors (i...
October 11, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29040016/centella-asiatica-fraction-3-suppresses-the-nuclear-factor-erythroid-2-related-factor-2-anti-oxidant-pathway-and-enhances-reactive-oxygen-species-mediated-cell-death-in-cancerous-lung-a549-cells
#16
Dhaneshree Bestinee Naidoo, Alisa Phulukdaree, Krishnan Anand, Vikash Sewram, Anil Amichund Chuturgoon
Centella asiatica is a tropical medicinal plant that is commonly used in traditional medicine. Medicinal properties of C. asiatica include anti-oxidant, anti-inflammatory, and anti-cancer activity. We investigated the anti-oxidant and anti-proliferative/cytotoxic effects of a semi-purified fraction of C. asiatica ethanolic leaf extract (C3) in cancerous lung A549 cells. C3 was obtained by silica column fractionation and identified by using thin-layer chromatography and gas chromatography mass spectrometry. Cytotoxicity of C3 in A549 cells was evaluated (cell viability assay-WST-1; 24 h; [0...
October 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29039549/downregulation-of-caspase%C3%A2-3-alleviates-mycoplasma%C3%A2-pneumoniae%C3%A2-induced-apoptosis-in-alveolar-epithelial-cells
#17
Shan Shi, Xiaolei Liu, Haibo Li
Mycoplasma pneumoniae (M. pneumoniae) infection is closely associated with pneumonia in children. Apoptosis of alveolar epithelial cells is involved in the development of pneumonia in children. The present study aimed to examine how caspase‑3 influences apoptosis rates in M. pneumoniae‑infected alveolar epithelial cells. A549 alveolar epithelial cells were treated with M. pneumoniae, and cells and culture supernatant were collected at different time points. Alterations in apoptosis rates and caspase‑3 mRNA and protein levels were measured for each treatment group...
October 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039521/antitumoral-effect-of-arsenic-compound-sodium-metaarsenite-kml001-on-multiple-myeloma-cells
#18
Seo Ju Kim, Eun Shil Kim, Sujong Kim, Jieun Uhm, Young Woong Won, Byeong Bae Park, Jung Hye Choi, Young Yiul Lee
KML001 (sodium metaarsenite;NaAs2O3) is known to have antitumor activity against a variety of cancers. In this study, we examined its effect on multiple myeloma (MM). KML001 reduced the growth of all MM cell lines examined with an IC50 of 5x10‑8 M. Exposure to KML001 (5x10‑8 M) decreased levels of cyclins A/B1/D1/E1, CDK2/4/6 in U266 cells and increased the p21 and p27 levels. Furthermore, p21 became bound to CDK2/4/6, resulting in a reduction of CDK2/4/6 kinase activity. The cleaved forms of Bcl-2, and caspases‑3, ‑8 and ‑9 were detected, and the anti-apoptotic molecule, Bax, also increased...
October 16, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29039470/effects-of-baicalein-on-proliferation-apoptosis-migration-and-invasion-of-ewing-s-sarcoma-cells
#19
Conglin Ye, Xiaolong Yu, Jin Zeng, Min Dai, Bin Zhang
Ewing's sarcoma (ES) is a rare tumor that is more frequent in pediatric and adolescent age groups. In the past few decades, long-term survival in affected patients has improved due to the success of multimodal therapy. However, long-term survival is inevitably restricted by the late side-effects of chemotherapy. Besides, early metastasis also contributes to the poor prognosis of ES. Recently, traditional Chinese medicines (TCMs) have increasingly attracted interest due to the promising clinical results and fewer side-effects for the treatment of cancers...
October 10, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29039468/limited-activation-of-the-intrinsic-apoptotic-pathway-plays-a-main-role-in-amyloid-%C3%AE-induced-apoptosis-without-eliciting-the-activation-of-the-extrinsic-apoptotic-pathway
#20
Md Imamul Islam, Md Golam Sharoar, Eun-Kyoung Ryu, Il-Seon Park
Amyloid-β (Aβ), a main pathogenic factor of Alzheimer's disease (AD), induces apoptosis accompanied by caspase activation. However, limited caspase activation and the suppression of the intrinsic apoptotic pathway (IAPW) are frequently observed upon Aβ treatment. In this study, we investigated whether these suppressive effects of Aβ can be overcome; we also examined the death-related pathways. Single treatments of cells with Aβ42 for up to 48 h barely induced caspase activation. In cells treated with Aβ42 twice for 2 h followed by 22 h (2+22 h) or for longer durations, the apoptotic protease activating factor-1 (Apaf-1) apoptosome was formed and caspases-3 and -9 were activated to a certain extent, suggesting the activation of the IAPW...
October 16, 2017: International Journal of Molecular Medicine
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