keyword
MENU ▼
Read by QxMD icon Read
search

caspase 1

keyword
https://www.readbyqxmd.com/read/29470982/rip3-deficiency-protects-against-traumatic-brain-injury-tbi-through-suppressing-oxidative-stress-inflammation-and-apoptosis-dependent-on-ampk-pathway
#1
Zai-Ming Liu, Qian-Xue Chen, Zhi-Biao Chen, Dao-Feng Tian, Ming-Chang Li, Jun-Min Wang, Long Wang, Bao-Hui Liu, Shen-Qi Zhang, Fei Li, Hui Ye, Long Zhou
Traumatic brain injury (TBI) is a leading cause of disability and mortality in young adults worldwide. The pathophysiology is not fully understood. Programmed necrosis (necroptosis) is a newly identified mechanism of cell death combining features of both apoptosis and necrosis. Receptor-interacting protein 3 (RIP3) plays an important role in programmed necrosis. However, the effect of RIP3-related pathway in TBI is little to be known. We attempted to explore the significance of RIP3 in regulating TBI in vivo...
February 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29470962/indomethacin-induced-glioma-apoptosis-involving-ceramide-signals
#2
Cheng-Yi Chang, Jian-Ri Li, Chih-Cheng Wu, Jiaan-Der Wang, Ching-Ping Yang, Wen-Ying Chen, Wen-Yi Wang, Chun-Jung Chen
Nonsteroidal anti-inflammatory drugs (NSAIDs) are increasingly implicated in the prevention and treatment of cancers apart from their known inhibitory effects on eicosanoid production. One of the NSAIDs, indomethacin, in particular shows promising antineoplastic outcome against glioma. To extend such finding, we here studied in human H4 and U87 glioma cells the possible involvement of the ceramide/protein phosphatase 2A (PP2A)/Akt axis in the indomethacin-induced apoptosis. We found that the induced apoptosis was accompanied by a series of biochemical events, including intracellular ceramide generation, PP2A activation, Akt dephosphorylation, Mcl-1 and FLICE inhibiting protein (FLIP) transcriptional downregulation, Bax mitochondrial distribution, and caspase 3 activation...
February 19, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29470694/new-prospects-of-mesenchymal-stem-cells-for-ameliorating-temporal-lobe-epilepsy
#3
Neveen A Salem, Marwa El-Shamarka, Yasser Khadrawy, Shaimaa El-Shebiney
Temporal lobe epilepsy (TLE) is present in 30% of epileptic patients and does not respond to conventional treatments. Bone marrow derived mesenchymal stem cells (BMSCs) induce endogenous neural stem cells, inhibit neurodegeneration, and promote brain self-repair mechanisms. The present study addresses the feasibility of BMSCs transplantation against pilocarpine-induced TLE experimentally. BMSCs were injected either intravenously (IV) or in hippocampus bilaterally (IC). Increased cell count of BMSCs was achieved via IC route...
February 22, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29470442/phycocyanin-protects-against-uvb-induced-apoptosis-through-the-pkc-%C3%AE-%C3%AE-ii-nrf-2-ho-1-dependent-pathway-in-human-primary-skin-cells
#4
Ki Mo Kim, Joo Young Lee, A-Rang Im, Sungwook Chae
Phycocyanin (Pc) is one of the active pigment constituents of Spirulina microalgae. It has been used for its potent antioxidant and anti-inflammatory properties. However, the protective effects of Pc against ultraviolet-B (UVB)-induced primary skin cells damage are still undefined. In the present study, we investigated whether Pc prevented UVB-induced apoptotic cell death in human dermal fibroblasts (HDF) and human epidermal keratinocytes (HEK). Pc induced the transcription of heme oxygenase-1 (HO-1). Furthermore, Pc treatments resulted in a marked increase in nuclear factor erythroid-derived 2 (NF-E2)-like 2 (Nrf-2) nuclear translocation...
February 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29468175/rapamycin-prevents-cerebral-stroke-by-modulating-apoptosis-and-autophagy-in-penumbra-in-rats
#5
Meiling Wu, Huadan Zhang, Jiejing Kai, Feng Zhu, Jingyin Dong, Ziwei Xu, Michael Wong, Ling-Hui Zeng
Objective: Whether activation or inhibition of the mTOR pathway is beneficial to ischemic injury remains controversial. It may result from the different reaction of ischemic penumbra and core to modulation of mTOR pathway after cerebral ischemia-reperfusion injury in rats. Methods: Longa's middle cerebral artery occlusion (MCAO) method was conducted to induce the focal cerebral ischemia-reperfusion. Western blot analysis was used to examine the protein expression involving mTOR pathway, apoptosis, and autophagy-related proteins...
February 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29467942/-in-vitro-in-vivo-and-ex-vivo-demonstration-of-the-antitumoral-role-of-hypocretin-1-orexin-a-and-almorexant-in-pancreatic-ductal-adenocarcinoma
#6
Stéphanie Dayot, Daniela Speisky, Anne Couvelard, Pierre Bourgoin, Valérie Gratio, Jérôme Cros, Vinciane Rebours, Alain Sauvanet, Pierre Bedossa, Valérie Paradis, Philippe Ruszniewski, Alain Couvineau, Thierry Voisin
Pancreatic ductal adenocarcinoma (PDAC) is still the poorest prognostic tumor of the digestive system. We investigated the antitumoral role of orexin-A and almorexant in PDAC. We analyzed the orexin receptor type 1 (OX1R) expression by immunohistochemistry in human normal pancreas, PDAC and its precursor dysplastic intraepithelial lesions. We used PDAC-derived cell lines and fresh tissue slices to study the apoptotic role of hypocretin-1/orexin-A and almorexant in vitro and ex vivo . We analyzed in vivo the hypocretin-1/orexin-A and almorexant effect on tumor growth in mice xenografted with PDAC cell lines expressing, or not, OX1R...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29467938/smad4-independent-activation-of-tgf-%C3%AE-signaling-by-muc1-in-a-human-pancreatic-cancer-cell-line
#7
Priyanka Grover, Sritama Nath, Monica D Nye, Ru Zhou, Mohammad Ahmad, Pinku Mukherjee
Pancreatic Ductal Adenocarcinoma (PDA) has a mortality rate that nearly matches its incidence rate. Transforming Growth Factor Beta (TGF-β) is a cytokine with a dual role in tumor development switching from a tumor suppressor to a tumor promoter. There is limited knowledge of how TGF-β function switches during tumorigenesis. Mucin 1 (MUC1) is an aberrantly glycosylated, membrane-bound, glycoprotein that is overexpressed in >80% of PDA cases and is associated with poor prognosis. In PDA, MUC1 promotes tumor progression and metastasis via signaling through its cytoplasmic tail (MUC1-CT) and interacting with other oncogenic signaling molecules...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29467937/temozolomide-sirolimus-and-chloroquine-is-a-new-therapeutic-combination-that-synergizes-to-disrupt-lysosomal-function-and-cholesterol-homeostasis-in-gbm-cells
#8
Sanford P C Hsu, John S Kuo, Hsin-Chien Chiang, Hsin-Ell Wang, Yu-Shan Wang, Cheng-Chung Huang, Yi-Chun Huang, Mau-Shin Chi, Minesh P Mehta, Kwan-Hwa Chi
Glioblastoma (GBM) cells are characterized by high phagocytosis, lipogenesis, exocytosis activities, low autophagy capacity and high lysosomal demand are necessary for survival and invasion. The lysosome stands at the cross roads of lipid biosynthesis, transporting, sorting between exogenous and endogenous cholesterol. We hypothesized that three already approved drugs, the autophagy inducer, sirolimus (rapamycin, Rapa), the autophagy inhibitor, chloroquine (CQ), and DNA alkylating chemotherapy, temozolomide (TMZ) could synergize against GBM...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29467931/toll-like-receptor-2-induces-adenosine-receptor-a2a-and-promotes-human-squamous-carcinoma-cell-growth-via-extracellular-signal-regulated-kinases-%C3%A2
#9
Chithra Devi Palani, Lalitha Ramanathapuram, Aroonwan Lam-Ubol, Zoya B Kurago
Patient treatment for oral squamous cell carcinoma (OSCC) not associated with Human papillomavirus remains problematic. OSCC microenvironment is typically inflamed and colonized by microorganisms, providing ligands for toll-like receptors (TLR). In immune cells TLR2 and TLR4 activate NF-kB and extracellular signal regulated kinase (ERK)1/2 pathways, leading to upregulation of inhibitory adenosine receptors A2a and A2b, and reduction in stimulatory A1 and A3. How TLR and adenosine receptors function in SCC cells is not understood...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29467906/%C3%AE-elemene-enhances-anticancer-and-anti-metastatic-effects-of-osteosarcoma-of-ligustrazine-in-vitro-and-in-vivo
#10
Min Fang, Xiaolong Mei, Hui Yao, Tao Zhang, Tao Zhang, Na Lu, Yanshi Liu, Wenyue Xu, Chunyou Wan
The present study aimed to determine the anticancer effects of the combination of β-elemene and ligustrazine in vitro as well as in in vivo . Following evaluation using an MTT assay, β-elemene, ligustrazine and the β-elemene-ligustrazine combination treatments all exhibited the capacity to inhibit the growth of OS-732 cells, with inhibitory rates of 43.3, 54.4, and 75.0%, respectively. Using a flow cytometry assay, it was determined that the β-elemene-ligustrazine combination possessed the highest apoptotic rate (30...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467903/effect-of-selective-inhibition-of-aquaporin-1-on-chemotherapy-sensitivity-of-j82-human-bladder-cancer-cells
#11
Xuefeng Zhang, Yun Chen, Liming Dong, Benkang Shi
The occurrence of resistance to mitomycin C (MMC) often limits its clinical effectiveness. Combination therapy thus is employed to overcome this treatment resistance. The present study aimed to establish a novel J82 bladder cancer cell line so as to study the effect of inhibition of aquaporin 1 (AQP-1) on chemotherapy sensitivity of J82 bladder cancer cells. A novel J82 bladder cancer cell line whose expression of AQP-1 is inhibited was established through transfection of J82 cells with newly constructed recombinant plasmid...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467878/parthenolide-facilitates-apoptosis-and-reverses-drug-resistance-of-human-gastric-carcinoma-cells-by-inhibiting-the-stat3-signaling-pathway
#12
Hua Li, Hang Lu, Meng Lv, Qingsheng Wang, Yuping Sun
In the present study, SGC-7901/DDP cells were treated with different concentrations of parthenolide (PN) (2.5-15 µmol/l), cisplatin (DDP) (1.25-15 µg/ml) and PN+DDP. The proliferation inhibition rates were measured using an MTT assay, and the synergies of PN and DDP were analyzed. The effect of PN and DDP on SGC-7901/DDP cell proliferation demonstrated a time- and concentration-dependent association, and a synergy between PN and DDP was identified. DAPI staining and flow cytometry results indicated that 15 µmol/l PN significantly induced SGC-7901/DDP apoptosis and G1 phase arrest compared with the untreated control group...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467874/effects-of-nob1-on-the-pathogenesis-of-osteosarcoma-and-its-expression-on-the-chemosensitivity-to-cisplatin
#13
Leiming Luo, Yuanhui Wang, Yiran Yin, Jianhua Ge, Xiaobo Lu
The effects of NIN1/RPN12 binding protein 1 homolog (NOB1) on the pathogenesis of osteosarcoma and its expression on the chemosensitivity to cisplatin were investigated. Seventy-four patients with osteosarcoma who received surgical resection in The Affiliated Hospital of Southwest Medical University (Sichuan, China) from September 2013 to September 2016 were enrolled in this study. The expression of NOB1 in cancer and cancer-adjacent tissues of patients was detected by reverse transcription-polymerase chain reaction, and the relationship between NOB1 expression and the pathogenesis of osteosarcoma was analyzed...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467861/induction-of-apoptosis-by-an-oleanolic-acid-derivative-in-smmc-7721-human-hepatocellular-carcinoma-cells-is-associated-with-mitochondrial-dysfunction
#14
Xinfeng Fan, Penglong Wang, Yaogui Sun, Junbing Jiang, Haiyuan Du, Zhirui Wang, Zhibian Duan, Haimin Lei, Hongquan Li
The aim of the present study was to investigate the effects of an oleanolic acid derivative, a novel antitumor drug, on the growth of SMMC-7721 human hepatocellular carcinoma cells and the underlying mechanism. An MTT assay was performed to determine the cytotoxicity of the oleanolic acid derivative. Cell membrane integrity was assessed using fluorescence microscopy to assess the uptake of annexin V-FITC/propidium iodide (PI). Western blotting was used to detect the apoptosis-associated proteins B cell lymphoma-2 (Bcl-2), Bax, caspase-9 and caspase-3...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467847/mirna-223-3p-regulates-nlrp3-to-promote-apoptosis-and-inhibit-proliferation-of-hep3b-cells
#15
Lingfeng Wan, Xin Yuan, Mantian Liu, Boyu Xue
Hepatocellular carcinoma (HCC) is a major malignant tumor type with a high incidence and mortality. Infection with hepatitis virus is a high-risk factor. Previous studies have demonstrated that microRNA (miR)-223 was downregulated in HCC tissues. NOD-like receptor family, pyrin domain containing 3 (NLRP3)-is a potential target of miR-223 and has a vital role in hepatitis infection. The present study was performed to investigate the role of miR-223 in the proliferation and apoptosis of HCC cells through regulating NLRP3...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29467841/hepatoprotective-effect-of-methyl-ferulic-acid-against-carbon-tetrachloride-induced-acute-liver-injury-in-rats
#16
Chengfang Yang, Li Li, Zuheng Ma, Yujuan Zhong, Wenxiao Pang, Meili Xiong, Shuping Fang, Yongwen Li
The present study aimed to investigate the hepatoprotective effects of methyl ferulic acid (MFA) against oxidative stress and apoptosis in acute liver injury induced by carbon tetrachloride (CCl4 ) in rats, as well as the underlying mechanisms. Sprague Dawley rats were treated with CCl4 after oral administration of MFA (25, 50, and 100 mg/kg) or dimethyl diphenyl bicarboxylate (200 mg/kg) for 7 days. The hepatoprotective effects of MFA were determined by analyzing serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities as well as changes of oxidant parameters...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29467720/the-steroid-hormone-20-hydroxyecdysone-regulates-the-conjugation-of-autophagy-related-proteins-12-and-5-in-a-concentration-and-time-dependent-manner-to-promote-insect-midgut-programmed-cell-death
#17
Yong-Bo Li, Ting Yang, Jin-Xing Wang, Xiao-Fan Zhao
Autophagy requires the conjugation of autophagy-related protein 12 (ATG12) to autophagy-related protein 5 (ATG5) through covalent attachment. However, the signals regulating ATG12-ATG5 conjugation are unclear. The larval midgut of lepidopteran insects performs autophagy and apoptosis sequentially during the transition of larvae to pupae under regulation by the steroid hormone 20-hydroxyecdysone (20E), thus representing a model to study steroid hormone regulation of ATG12-ATG5 conjugation. In the present study, using the lepidopteran insect Helicoverpa armigera as a model, we report that 20E regulates the conjugation of ATG12-ATG5 in a concentration and time-dependent manner...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29467390/fgf1-induces-resistance-to-chemotherapy-in-ovarian-granulosa-tumor-cells-through-regulation-of-p53-mitochondrial-localization
#18
Sevasti Manousakidi, Arnaud Guillaume, Caroline Pirou, Sylvina Bouleau, Bernard Mignotte, Flore Renaud, Nathalie Le Floch
Ovarian cancer remains associated with a high mortality rate and relapse is too frequently seen after chemotherapeutic treatment of granulosa cell tumors (GCTs) or epithelial ovarian cancers (EOCs). It is thus of major importance to progress in the knowledge of the molecular mechanisms underlying chemoresistance of ovarian tumors. Overexpression of Fibroblast Growth Factor 1 (FGF1) is observed in various cancers, correlates with poor survival and could be responsible for resistance to platinum-based chemotherapy of serous ovarian cancers...
February 21, 2018: Oncogenesis
https://www.readbyqxmd.com/read/29466702/inflammasome-biology-molecular-pathology-and-therapeutic-implications
#19
REVIEW
Fawaz Awad, Eman Assrawi, Camille Louvrier, Claire Jumeau, Sophie Georgin-Lavialle, Gilles Grateau, Serge Amselem, Irina Giurgea, Sonia-Athina Karabina
Inflammasomes are intracellular multiprotein signaling complexes, mainly present in myeloid cells. They commonly assemble around a cytoplasmic receptor of the nucleotide-binding leucine-rich repeat containing receptor (NLR) family, although other cytoplasmic receptors like pyrin have been shown to form inflammasomes. The nucleation of the multiprotein scaffolding platform occurs upon detection of a microbial, a danger or a homeostasis pattern by the receptor that will, most commonly, associate with the adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD) through homotypic domain interactions resulting in recruitment of procaspase-1...
February 18, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29466287/comparison-of-inhibitory-capacities-of-6-8-and-10-gingerols-shogaols-on-the-canonical-nlrp3-inflammasome-mediated-il-1%C3%AE-secretion
#20
Su-Chen Ho, Yi-Huang Chang
Endogenous noninfectious substances that mediate the nucleotide oligomerization domain (NOD)-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation and interleukin (IL)-1β secretion causes inappropriate sterile inflammation and is implicated in the pathogenesis of several chronic diseases, such as type 2 diabetes mellitus, gout, atherosclerosis and Alzheimer's disease. Consequently, dietary phytochemicals exhibiting capacities to suppress canonical NLRP3 inflammasome-mediated IL-1β secretion can be a reliable supplement to prevent such diseases...
February 21, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
keyword
keyword
95914
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"