Jessica J Y Ong, Jeonghun Oh, Xiang Yong Ang, Renugah Naidu, Trang T T Chu, Jae Hyoung Im, Umar Manzoor, Tuyet Kha Nguyen, Seok-Won Na, Eun-Taek Han, Christeen Davis, Won Sun Park, Wanjoo Chun, Hojong Jun, Se Jin Lee, Sunghun Na, Jerry K Y Chan, YongKeun Park, Bruce Russell, Rajesh Chandramohanadas, Jin-Hee Han
Malaria is a life-threatening infectious disease caused by parasites of the genus Plasmodium. Understanding the biological features of various parasite forms is important for the optical diagnosis and defining pathological states, which are often constrained by the lack of ambient visualization approaches. Here, we employ a label-free tomographic technique to visualize the host red blood cell (RBC) remodeling process and quantify changes in biochemical properties arising from parasitization. Through this, we provide a quantitative body of information pertaining to the influence of host cell environment on growth, survival, and replication of P...
October 22, 2022: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy