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https://www.readbyqxmd.com/read/28869457/anti-inflammatory-effects-of-a-novel-iron-chelator-dibi-in-experimental-sepsis
#1
Taylor Thorburn, Maral Aali, Lisanne Kostek, Chloe LeTourneau-Paci, Patricia Colp, Juan Zhou, Bruce Holbein, David Hoskin, Christian Lehmann
BACKGROUND: Iron catalyzes the generation of reactive oxygen species (ROS) as part of the innate antimicrobial defense. During sepsis, the dysregulated systemic inflammatory response to infection, iron homeostasis becomes disrupted, generating an excess of ROS causing damage to tissues. This can be potentially suppressed using iron chelators that selectively bind iron to prevent its participation in ROS-related inflammatory reactions. OBJECTIVE: We hypothesize that administration of DIBI, a novel iron-chelator, attenuates the dysregulated systemic immune response and reduces tissue damage in experimental endotoxemia...
August 28, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28729394/body-fat-of-rats-of-different-age-groups-and-nutritional-states-assessment-by-micro-ct-and-skinfold-thickness
#2
Eva Tekus, Alexandra Miko, Nora Furedi, Ildiko Rostas, Judit Tenk, Tamas Kiss, István Szitter, Marta Balasko, Zsuzsanna Helyes, Marta Wilhelm, Erika Petervari
Obesity presents a growing public health problem. Therefore, the analysis of body composition is important in clinical practice as well as in animal research models of obesity, hence precise methods for the assessment of body fat would be essential. We aimed to evaluate in vivo abdominal micro-computed tomography scan restricted to the L1-L3 region (micro-CT(L1-L3)), a skinfold thickness-based method (STM) and post mortem body composition analysis (PMA) with regard to whole-body micro-CT scan in rats. Male Wistar rats of different age-groups (from 3 to 24 months) and nutritional states (normally fed, high-fat diet-induced obese, calorie-restricted) were used...
July 20, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28545460/intraperitoneal-implantation-of-life-long-telemetry-transmitters-in-three-rehabilitated-harbor-seal-pups
#3
Markus Horning, Martin Haulena, Justin F Rosenberg, Chad Nordstrom
BACKGROUND: Pinnipeds, including many phocid species of concern, are inaccessible and difficult to monitor for extended periods using conventional, externally attached telemetry devices that are shed during the annual molt. Archival satellite transmitters were implanted intraperitoneally into three stranded Pacific harbor seal pups (Phoca vitulina richardii) that completed rehabilitation, to evaluate the viability of this surgical technique for the deployment of life long telemetry devices in phocids...
May 25, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28053883/curcumin-reverses-neurochemical-histological-and-immuno-histochemical-alterations-in-the-model-of-global-brain-ischemia
#4
Glaura Fernandes Teixeira de Alcântara, Eudes Simões-Neto, Giovany Michely Pinto da Cruz, Maria Elizabeth Pereira Nobre, Kelly Rose Tavares Neves, Geanne Matos de Andrade, Gerly Anne de Castro Brito, Glauce Socorro de Barros Viana
Curcumin, a curcuminoid from Curcuma longa, presents antioxidant and anti-inflammatory actions and, among pathological changes of cerebral ischemic injury, inflammation is an important one. The objectives were to study the neuroprotective action of curcumin, in a model of global ischemia. Male Wistar rats (sham-operated, ischemic untreated and ischemic treated with curcumin, 25 or 50 mg/kg, p.o.) were anesthesized and their carotid arteries occluded, for 30 min. The SO group had the same procedure, except for carotid occlusion...
January 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28039643/respiratory-dynamics-and-dead-space-to-tidal-volume-ratio-of-volume-controlled-versus-pressure-controlled-ventilation-during-prolonged-gynecological-laparoscopic-surgery
#5
Ming Lian, Xiao Zhao, Hong Wang, Lianhua Chen, Shitong Li
BACKGROUND: Laparoscopic operations have become longer and more complex and applied to a broader patient population in the last decades. Prolonged gynecological laparoscopic surgeries require prolonged pneumoperitoneum and Trendelenburg position, which can influence respiratory dynamics and other measurements of pulmonary function. We investigated the differences between volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV) and tried to determine the more efficient ventilation mode during prolonged pneumoperitoneum in gynecological laparoscopy...
December 30, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27737406/endovascular-abdominal-aneurysm-repair-in-women-what-are-the-differences-between-the-genders
#6
Rui Machado, Gabriela Teixeira, Pedro Oliveira, Luís Loureiro, Carlos Pereira, Rui Almeida
Introduction: Abdominal aortic aneurysm has a lower incidence in the female population, but a higher complication rate. It was been hypothesized that some anatomical differences of abdominal aortic aneurysm in women could be responsible for that. We proposed to analyze our data to understand the differences in the clinical and anatomical characteristics and the outcomes of patients undergoing endovascular aneurysm repair, according to gender. Methods: A retrospective analysis of patients undergoing endovascular aneurysm repair between 2001-2013 was performed...
May 2016: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/27556312/is-age-a-determinant-factor-in-evar-as-a-predictor-of-outcomes-or-in-the-selection-procedure-our-experience
#7
Rui Machado, Gabriela Teixeira, Pedro Oliveira, Luís Loureiro, Carlos Pereira, Rui Almeida
INTRODUCTION: Endovascular aneurysm repair (EVAR) is the therapy of choice in high risk patients with abdominal aortic aneurysm. The good results described are leading to the broadening of clinical indications to younger patients. However, reintervention rates seem higher and even with successful treatment sometimes there is growth of the aneurysm sac and rupture, meaning a failure of the therapeutic goal. This study proposes to analyse the impact of age in patients' selection and post-EVAR results...
April 2016: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/27318919/-effect-of-dexmedetomidine-infusion-on-postoperative-recovery-for-patients-undergoing-major-spinal-surgery-during-propofol-anesthesia
#8
RANDOMIZED CONTROLLED TRIAL
B Y Li, Z Y Geng, D X Wang
OBJECTIVE: To evaluate the effect of intraoperative dexmedetomidine (DEX) infusion during propofol intravenous anesthesia on postoperative recovery after major spinal surgery. METHODS: Sixty patients aged 18 to 65 (American Society of Anesthesiologists, ASA I-II), scheduled for spinal surgery from January 2014 to May 2014 were randomized into two groups. The DEX group (n=30) received 0.5 μg/kg of DEX ten minutes before anesthesic induction, followed by an infusion of DEX at 0...
June 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27181886/-comparison-of-the-effectiveness-of-different-supraglottic-ventilation-methods-during-bronchial-thermoplasty
#9
COMPARATIVE STUDY
Wen Wang, Jiang-tao Lin, Nan Su, Ying Nong, Hong Hong, Yi-qing Yin, Cheng-hui Li
OBJECTIVE: To compare the effectiveness of high-frequency jet ventilation via Wei jet nasal airway and controlled ventilation with improved laryngeal mask airway during bronchial thermoplasty. METHODS: Twenty-eight patients undergoing bronchial thermoplasty were equally divided into two groups: group A (high-frequency jet ventilation through Wei jet nasal airway) and group B (controlled ventilation with improved laryngeal mask airway). Pulse oxygenation,heart rate,and mean arterial blood pressure were recorded after entering the operating room (T0), 1 minute after administration/induction (T1), bronchoscope inserting (T2), 15 minutes (T3)/30 minutes (T4)/45 minutes (T5) after ventilation,at the end of the operation (T6), and at the recovery of patients' consciousness (T7)...
April 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/27073138/intravenous-lipid-emulsion-prolongs-survival-in-rats-intoxicated-with-digoxin
#10
Bülent Serhan Yurtlu, Şule Özbilgin, Derya Arslan Yurtlu, Nilay Boztaş, Gonca Kamacı, Mahmut Akaltun, Volkan Hancı, Osman Yılmaz
BACKGROUND: Intravenous lipid emulsion eliminates the toxicity-related symptoms of several drugs. We hypothesized that intravenous lipid emulsion prolongs the survival time in digoxin-intoxicated rats. METHODS: Electrocardiograms of 14 anesthesized Wistar rats were monitored. All of the rats received digoxin infusion at a rate of 12 mL/h (0.25 mg/mL). Five minutes after the start of digoxin infusion, animals were treated either with 12.4 mL/kg intravenous lipid emulsion (group L) or saline (group C)...
June 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27017510/the-effect-of-3-4-dihydroxyflavonol-on-lipid-peroxidation-in-rats-with-cerebral-ischemia-reperfusion-injury
#11
Merve Caliskan, Rasim Mogulkoc, Abdulkerim Kasim Baltaci, Esma Menevse
The aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental brain ischemia-reperfusion in rats. Present study was performed on the 34 male Wistar-albino rats, weigth 350-400 g. Experiment groups were designed as 1-Sham; 2-Ischemia-reperfusion; animal were anesthesized and carotid arteried were clemped for 20 min and reperfusion (7 days). 3-DiOHF + Ischemia-reperfusion; DiOHF was given to animals as 10 mg/kg by intraperitoneal. 4- Ischemia + DiOHF + Reperfusion; 5- Ischemia-reperfusion + DiOHF...
July 2016: Neurochemical Research
https://www.readbyqxmd.com/read/26780408/plasma-mepivacaine-concentrations-in-patients-undergoing-third-molar-surgery
#12
RANDOMIZED CONTROLLED TRIAL
H C Scarparo, R N Maia, Ea Dos Santos Filho, Ecs Soares, Fwg Costa, Csr Fonteles, T P Bezerra, T R Ribeiro, N R Romero
BACKGROUND: Local anaesthetic-related systemic toxicity mainly results from elevated plasma concentrations of these drugs. We hypothesized that intraoral injection of submaximal doses of mepivacaine does not lead to toxic levels of this drug in blood. This study evaluated the plasma levels of mepivacaine in third molars surgeries. METHODS: Twenty-one patients were randomly assigned into two groups: group I (two unilateral third molars; submaximal dose of mepivacaine 108 mg with epinephrine 54 μg) and group II (four third molars; submaximal dose of mepivacaine 216 mg with epinephrine 108 μg)...
December 2016: Australian Dental Journal
https://www.readbyqxmd.com/read/26272725/short-term-anesthesia-inhibits-formalin-induced-extracellular-signal-regulated-kinase-erk-activation-in-the-rostral-anterior-cingulate-cortex-but-not-in-the-spinal-cord
#13
Keri K Tochiki, Maria Maiarù, James R C Miller, Stephen P Hunt, Sandrine M Géranton
BACKGROUND: The rostral anterior cingulate cortex (rACC) has been implicated in the negative affective response to injury, and importantly, it has been shown that activation of extracellular signal-regulated kinase (ERK) signaling in the rACC contributes to the full expression of the affective component of pain in rodents. In this study, we investigated whether administration of anesthesia at the time of injury could reduce phosphorylated-ERK (PERK) expression in the rACC, which might eliminate the negative affective component of noxious stimulation...
2015: Molecular Pain
https://www.readbyqxmd.com/read/26113359/borderline-tuberculoid-leprosy-in-childhood-onset-systemic-lupus-erythematosus-patient
#14
V A P Lopes, D M R Lourenço, A Guariento, M A Trindade, J Avancini, C A Silva
Leprosy is a contagious and chronic systemic granulomatous disease caused by the bacillus Mycobacterium leprae. To our knowledge, no case of leprosy in a childhood-onset systemic lupus erythematosus (c-SLE) patient has been reported. For a period of 31 years, 312 c-SLE patients were followed at the Pediatric Rheumatology Unit of our University Hospital. One of them (0.3%) had tuberculoid leprosy skin lesions during the disease course and is here reported. A 10-year-old boy from Northwest of Brazil was diagnosed with c-SLE based on malar rash, photosensitivity, oral ulcers, lymphopenia, proteinuria, positive antinuclear antibodies, anti-double-stranded DNA, anti-Sm and anti-Ro/SSA autoantibodies...
November 2015: Lupus
https://www.readbyqxmd.com/read/26071996/refractory-status-epilepticus-due-to-smart-syndrome
#15
Sonia Jaraba, Oriol Puig, Júlia Miró, Roser Velasco, Sara Castañer, Laura Rodríguez, Cristina Izquierdo, Marta Simó, Misericordia Veciana, Mercè Falip
INTRODUCTION: Stroke-like migraine attacks after radiation therapy (SMART) is a late-onset complication of brain irradiation of unknown physiopathology. Our aim was to present three patients with SMART syndrome who had clinical and neuroimage studies suggestive of status epilepticus. PATIENTS: Patient 1. A 69-year-old woman, who was treated with radiation therapy 14 years before her first admission to the Neurology Department, presented with several episodes of headache, speech disturbances, and weakness of left limbs with altered awareness...
August 2015: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/25953037/-pharmacological-treatment-of-the-premature-ejaculation
#16
A R Jurado López
Biomedical approach to premature ejaculation (PE) has permited a better phisiopatologycal knowledge and so the use of pharmacological agents for the treatment of this sexual dysfuncion. Most of the studies to evaluate the eficacy of these drugs were not carried at all the parameters which actually define PE: intravaginal ejaculatory latencie time (IELT) tested with watch, ejaculation control self perception cuantification (questionaries) and cuantification of generated consequences in patient and partner, if it existes...
July 2014: Semergen
https://www.readbyqxmd.com/read/25850210/in-vitro-and-in-vivo-antimicrobial-evaluation-of-alkaloidal-extracts-of-enantia-chlorantha-stem-bark-and-their-formulated-ointments
#17
Emmanuel E Nyong, Michael A Odeniyi, Jones O Moody
The in vitro and in vivo antimicrobial evaluation of the formulated ointment of alkaloidal extract of Enantia chlorantha Oliv. (Annonaceae) was the concern of this study. The alkaloidal fraction of the stem bark extract was formulated into simple ointment using British Pharmacopoeia formula for preparation of simple ointment. Agar diffusion and agar dilution methods were used for the in vitro antimicrobial studies. Ketoconazole 4000 μg/mL and tioconazole cream 1% were used as reference standards while normal saline was used as control...
January 2015: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/25818695/embelia-ribes-ameliorates-lipopolysaccharide-induced-acute-respiratory-distress-syndrome
#18
R L Shirole, N L Shirole, M N Saraf
ETHNOPHARMACOLOGICAL RELEVANCE: Embelia ribes Burm. f. (Fam. Myrsinaceae) locally known as Vidanga have been used for treating tumors, ascites, bronchitis, jaundice, diseases of the heart and brain in traditional Indian medicine. However, no scientific studies providing new insights in its pharmacological properties with respect to acute respiratory distress syndrome have been investigated. AIM: The present investigation aimed to elucidate the effectiveness of Embelin isolated from Embelia ribes seeds on attenuation of LPS-induced acute respiratory distress syndrome in murine models...
June 20, 2015: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/25812625/a-comparison-of-neurodegeneration-linked-with-neuroinflammation-in-different-brain-areas-of-rats-after-intracerebroventricular-colchicine-injection
#19
COMPARATIVE STUDY
Susmita Sil, Rupsa Ghosh, Moumita Sanyal, Debjani Guha, Tusharkanti Ghosh
Colchicine induces neurodegeneration, but the extent of neurodegeneration in different areas of the brain in relation to neuroinflammation remains unclear. Such information may be useful to allow for the development of a model to compare colchicine-induced neurodegeneration with other neurodegenerative diseases such as Alzheimer's Disease (AD). The present study was designed to investigate the extent of neurodegeneration along with neuroinflammation in different areas of the brain, e.g. frontal cortex, parietal cortex, occipital cortex, corpus striatum, amygdala and hippocampus, in rats along with memory impairment 21 days after a single intracerebroventricular (icv) injection of colchicine...
2016: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/25619865/effect-of-caffeine-on-intrinsic-mechanical-properties-of-normal-and-malignant-hyperthermia-susceptible-muscle
#20
Thomas Metterlein, Edmund Hartung, Norbert Roewer, Martin Anetseder
INTRODUCTION: Malignant hyperthermia (MH) is a potentially lethal anesthesic complication. Pathological symptoms develop after exposure to triggering substances. It remains uncertain whether cellular alterations pre-exist. Mechanical properties of isolated muscle bundles were examined before and after exposure to a triggering substance. METHODS: With prior written consent, muscle bundles of 12 MH-susceptible (MHS) and 56 MH-nonsusceptible (MHN) individuals were examined before and after exposure to incremental doses of caffeine...
October 2015: Muscle & Nerve
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