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https://www.readbyqxmd.com/read/29471520/effect-of-exposure-to-second-hand-smoke-from-husbands-on-biochemical-hyperandrogenism-metabolic-syndrome-and-conception-rates-in-women-with-polycystic-ovary-syndrome-undergoing-ovulation-induction
#1
Jian Li, Q Wu, Xiao-Ke Wu, Zhong-Ming Zhou, Ping Fu, Xiu-Hua Chen, Ying Yan, Xin Wang, Zheng-Wang Yang, Wei-Li Li, Elisabet Stener-Victorin, Richard S Legro, Ernest Hung-Yu Ng, Heping Zhang, Ben Willem J Mol, Chi Chiu Wang
STUDY QUESTION: Does second-hand smoke (SHS) exposure from husbands have adverse effects on sex hormones, metabolic profiles, clinical phenotypes and fertility outcomes in women with polycystic ovary syndrome (PCOS) undergoing ovulation induction? SUMMARY ANSWER: SHS exposure is associated with worsened biochemical hyperandrogenism, higher incidence of metabolic syndrome and reduced conception rates in women with PCOS. WHAT IS KNOWN ALREADY: Smoking in women impairs fecundity at some stages of the reproductive process including folliculogenesis, embryo transport, endometrial angiogenesis and uterine blood flow...
February 20, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29471389/the-effect-of-paternal-factors-on-perinatal-and-paediatric-outcomes-a-systematic-review-and-meta-analysis
#2
Nan B Oldereid, Ulla-Britt Wennerholm, Anja Pinborg, Anne Loft, Hannele Laivuori, Max Petzold, Liv Bente Romundstad, Viveca Söderström-Anttila, Christina Bergh
BACKGROUND: Maternal factors, including increasing childbearing age and various life-style factors, are associated with poorer short- and long-term outcomes for children, whereas knowledge of paternal parameters is limited. Recently, increasing paternal age has been associated with adverse obstetric outcomes, birth defects, autism spectrum disorders and schizophrenia in children. OBJECTIVE AND RATIONALE: The aim of this systematic review is to describe the influence of paternal factors on adverse short- and long-term child outcomes...
February 15, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29470837/past-present-and-future-approaches-to-the-prevention-and-treatment-of-respiratory-syncytial-virus-infection-in-children
#3
REVIEW
Eric A F Simões, Louis Bont, Paolo Manzoni, Brigitte Fauroux, Bosco Paes, Josep Figueras-Aloy, Paul A Checchia, Xavier Carbonell-Estrany
INTRODUCTION: The REGAL (RSV Evidence - A Geographical Archive of the Literature) series has provided a comprehensive review of the published evidence in the field of respiratory syncytial virus (RSV) in Western countries over the last 20 years. This seventh and final publication covers the past, present and future approaches to the prevention and treatment of RSV infection among infants and children. METHODS: A systematic review was undertaken of publications between January 1, 1995 and December 31, 2017 across PubMed, Embase and The Cochrane Library...
February 22, 2018: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/29470764/levels-of-circulating-mrna-for-the-tenascin-x-tnxb-gene-in-maternal-plasma-at-the-second-trimester-in-pregnancies-with-isolated-congenital-ventricular-septal-defects
#4
Danila Morano, Silvia Berto, Cristina Lapucci, Lara Walczer Baldinazzo, Daniela Prandstraller, Antonio Farina
OBJECTIVE: Maternal plasma is a source of circulating placental nucleic acids. In this study, we validated previous observations on abnormal levels of circulating messenger RNA (mRNA) for the tenascin-X gene in pregnancies with ventricular septal defects in the second trimester of pregnancy. METHODS: This was a bicentric retrospective study conducted from March 2016 to July 2017. Real-time polymerase chain reaction was used to identify abnormally expressed genes, comparing ten women carrying a euploid fetus with ventricular septal defects to 30 controls at 19-24 weeks of gestation...
February 22, 2018: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/29470685/the-effect-of-halogen-light-stimulation-on-duration-of-ultrasound-parameters-of-biophysical-profile-a-randomized-clinical-trial
#5
Mohammad Ghasem Hanafi, Aliakbar Sahraeizadeh
INTRODUCTION: The objective is to assess if fetal halogen light stimulation can reduce the time needed to obtain a normal biophysical profile (BPP). METHODS: Patients scheduled for a BPP and who satisfied the inclusion criteria were prospectively randomized to halogen light stimulation and no stimulation groups. The study group was exposed to handheld halogen light for 10 s whenever fetal breathing, movement, or tone was absent through the first 5 min of BPP. The time required to achieve complete BPP score was recorded...
February 22, 2018: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/29470508/preterm-delivery-and-small-for-gestation-outcomes-in-hiv-infected-pregnant-women-on-antiretroviral-therapy-in-rural-south-africa-results-from-a-cohort-study-2010-2015
#6
Terusha Chetty, Claire Thorne, Anna Coutsoudis
OBJECTIVES: Increasingly more women conceive on antiretroviral therapy (ART) with non-nucleoside reverse transcriptase-based regimens. This study assessed the effect of preconception tenofovir disoproxil fumarate (TDF)-lamivudine (3TC)/emtricitabine (FTC)-efavirenz (EFV) and post-conception TDF-(3TC/FTC)-EFV (versus other regimens) on preterm delivery (PTD) and small-for-gestational age (SGA) births. METHODS: We analysed data of 2549 HIV-infected women attending antenatal clinics in KwaZulu-Natal from 2010 through 2015 in this retrospective cohort study...
2018: PloS One
https://www.readbyqxmd.com/read/29470320/exchangeable-zinc-pool-size-at-birth-in-pakistani-small-for-gestational-age-and-appropriate-for-gestational-age-infants-do-not-differ-but-are-lower-than-in-us-infants
#7
Shabina Ariff, Nancy F Krebs, Jamie E Westcott, Michael Hambidge, Leland V Miller, Arjumand Rizvi, Sajid B Soofi, Zulfiqar A Bhutta
OBJECTIVES: Small for gestational age (SGA) infants are more susceptible to infectious morbidity and growth faltering compared to their appropriate for gestational age (AGA) counterparts. Zinc supplementation of SGA infants may be beneficial but the underlying susceptibility to zinc deficiency of SGA infants has not been examined. METHODS: In a community-based, observational, longitudinal study in a peri-urban settlement of Karachi, Pakistan, we compared the size of the exchangeable zinc pools (EZPs) in term SGA and AGA infants at birth and at 6 months of age, hypothesizing that the EZP would be lower in the SGA group...
March 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29470318/cesarean-section-on-the-risk-of-celiac-disease-in-the-offspring-the-teddy-study
#8
Sibylle Koletzko, Hye-Seung Lee, Andreas Beyerlein, Carin A Aronsson, Michael Hummel, Edwin Liu, Ville Simell, Kalle Kurppa, Åke Lernmark, William Hagopian, Marian Rewers, Jin-Xiong She, Olli Simell, Jorma Toppari, Anette-G Ziegler, Jeffrey Krischer, Daniel Agardh
OBJECTIVE: Cesarean section (C-section) is associated with various immune-mediated diseases in the offspring. We investigated the relationship between mode of delivery and celiac disease (CD) and CD autoimmunity (CDA) in a multinational birth cohort. METHODS: From 2004 to 2010, infants from the general population who tested positive for HLA DR3-DQ2 or DR4-DQ8 were enrolled in The Environmental Determinants for Diabetes in the Young (TEDDY) study. Children were annually screened for transglutaminase autoantibodies, if positive, they are retested after 3 to 6 months and those persistently positive defined as CDA...
March 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29470177/investigating-the-changes-in-amino-acid-values-in-premature-infants-a-pilot-study
#9
Yuqi Yang, Bin Yu, Wei Long, Huaiyan Wang, Ying Wang, Yunjuan Chen
BACKGROUND: The objective of the study was to investigate the changes in amino acid (AAs) values in premature infants. METHODS: A total of 2159 premature and/or low birth weight infants were recruited for this study. They were divided into three groups: premature infants with normal birth weight (G1), simple low birth weight infants (G2) and premature combined with low birth weight infants (G3). The tandem mass spectrometry technique was used to detect the levels of 11 AAs in neonatal blood...
February 22, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29470163/abdominal-exploration-in-neonates-using-transumbilical-exposure-compared-with-transverse-laparotomies
#10
Hanna Alemayehu, Richard Sola, Nhatrang H Le, David Juang, Pablo Aguayo, Jason D Fraser, Shawn D St Peter
INTRODUCTION: The vertical transumbilical incision (TU) technique during neonatal abdominal exploration involves dissection and ligation of umbilical vessels, which allow access to all quadrants of the abdomen and complete bowel evisceration with minimal violation to the anterior abdominal wall. We compared patient characteristics and outcomes for neonates undergoing TU with standard transverse exploration. MATERIALS AND METHODS: A single-center retrospective review of neonates who underwent abdominal exploration between January 2010 and September 2015 was conducted after obtaining Institutional Review Board approval...
February 22, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29470094/accuracy-user-acceptability-and-safety-evaluation-for-the-freestyle-libre-flash-glucose-monitoring-system-when-used-by-pregnant-women-with-diabetes
#11
Eleanor M Scott, Rudy W Bilous, Alexandra Kautzky-Willer
BACKGROUND: Accuracy of the FreeStyle Libre™ Flash Glucose Monitoring System has not been evaluated in pregnant women with diabetes. The aim of this study was to determine accuracy (compared to self-monitoring of blood glucose [SMBG]), clinical safety, and acceptability of the FreeStyle Libre System when used at home by this population. MATERIALS AND METHODS: Seventy-four participants, with type 1 (T1D, n = 24), type 2 (T2D, n = 11), or gestational (n = 39) diabetes, were enrolled across 13 sites (9 in United Kingdom, 4 in Austria)...
February 22, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29469945/extravillous-trophoblast-invasion-in-placenta-accreta-is-associated-with-differential-local-expression-of-angiogenic-and-growth-factors-a-cross-sectional-study
#12
Christina M Duzyj, Irina A Buhimschi, Christine A Laky, Genevieve Cozzini, Guomao Zhao, Mark Wehrum, Catalin S Buhimschi
OBJECTIVE: Placenta accreta is clinically associated with maternal uterine scar. Our objective was to investigate the biochemical contribution of maternal scarring to hyperinvasive trophoblast. We hypothesized that trophoblast over-invasion in placenta accreta is associated with aberrant invasion-site signaling of growth and angiogenic factors known to be involved in wound healing and promotion of cell invasion through the epithelial to mesenchymal cellular program. DESIGN: Cross-sectional series...
February 22, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29469926/folic-acid-supplementation-throughout-pregnancy-psychological-developmental-benefits-for-children
#13
Lesley-Anne Henry, Tony Cassidy, Marian McLaughlin, Kristina Pentieva, Helene McNulty, Colum P Walsh, Diane Lees-Murdock
AIM: To test the effect of folic acid supplements taken throughout pregnancy on children's psychosocial development. METHOD: A randomised controlled trial of folic acid supplementation in pregnancy, with parental rating using the Resiliency Attitudes and Skills Profile (RASP), the Strengths and Difficulties Questionnaire (SDQ), and the Trait Emotional Intelligence Questionnaire Child Short Form (TEIQue-CSF). Children aged 6-7 whose mothers received folic acid throughout pregnancy (n= 22) were compared to those whose mothers only received it during the first trimester (n=17)...
February 22, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29468771/home-blood-pressure-monitoring-in-a-hypertensive-pregnant-population
#14
H Perry, E Sheehan, B Thilaganathan, A Khalil
OBJECTIVE: The majority of patients with chronic or gestational hypertension do not develop pre-eclampsia. Home blood-pressure monitoring (HBPM) has the potential to offer a more accurate and acceptable means of monitoring hypertensive patients during pregnancy compared with traditional pathways of frequent outpatient monitoring. The aim of this study was to determine whether HBPM reduces visits to antenatal services and is safe in pregnancy. METHODS: This was a case-control study of 166 hypertensive pregnant women, which took place at St George's Hospital, University of London...
February 22, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29468711/estimating-recurrence-and-incidence-of-preterm-birth-subject-to-measurement-error-in-gestational-age-a-hidden-markov-modeling-approach
#15
Paul S Albert
Prediction of preterm birth as well as characterizing the etiological factors affecting both the recurrence and incidence of preterm birth (defined as gestational age at birth ≤ 37 wk) are important problems in obstetrics. The National Institute of Child Health and Human Development (NICHD) consecutive pregnancy study recently examined this question by collecting data on a cohort of women with at least 2 pregnancies over a fixed time interval. Unfortunately, measurement error due to the dating of conception may induce sizable error in computing gestational age at birth...
February 21, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29468676/relationships-among-gestational-age-and-birthweight-with-cognitive-deficits-in-children-and-adolescents-born-very-preterm
#16
Steven J Korzeniewski
No abstract text is available yet for this article.
February 22, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29468349/prediction-of-therapeutic-response-to-cyclooxygenase-inhibitors-in-preterm-infants-with-patent-ductus-arteriosus
#17
REVIEW
Yang Hu, Hongfang Jin, Yi Jiang, Junbao Du
Patent ductus arteriosus (PDA) is a morbid condition commonly seen in premature infants. Cyclooxygenase (COX) inhibitors, such as indomethacin and ibuprofen, are often used for the treatment of PDA in preterm infants, and they work by reducing the production of prostaglandin. However, as observed in clinical practice, not all PDAs in preterm infants can be closed using COX inhibitors. Some studies have demonstrated that gestational age, birth weight, B-type natriuretic peptide (BNP), and ductal diameter can predict the therapeutic responsiveness to COX inhibitors...
February 21, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29467994/neonatal-and-obstetrical-outcomes-of-pregnancies-in-systemic-lupus-erythematosus
#18
Reem Abdwani, Laila Al Shaqsi, Ibrahim Al-Zakwani
Objectives: Systemic lupus erythematous (SLE) is a chronic autoimmune disease that affects women primarily of childbearing age. The objective of this study was to determine the neonatal and maternal outcomes of pregnancies in SLE patients compared to pregnancies in healthy controls. Methods: We conducted a retrospective cohort study in a tertiary care hospital in Oman between January 2007 and December 2013. We analyzed 147 pregnancies and compared 56 (38.0%) pregnancies in women with SLE with 91 (61...
January 2018: Oman Medical Journal
https://www.readbyqxmd.com/read/29467523/early-low-dose-hydrocortisone-is-the-neurodevelopment-affected
#19
Gaston Ofman, Marta Perez, Kathryn N Farrow
TYPE OF INVESTIGATION: Prognosis; exploratory secondary analysis of an interventional randomized controlled trial. QUESTION: In extremely preterm infant (<28 weeks), is early low-dose hydrocortisone compared to placebo associated with neurodevelopmental impairment at 2 years of age? METHODS: Patients: Surviving infants enrolled in the PREMILOC trial conducted in France between 2008 and 2014. INTERVENTION: Double-blind, multicenter, randomized, placebo-controlled trial of infants born between 24 0/7 weeks and 27 6/7 weeks of gestation and before 24 h of postnatal age, assigned to receive either placebo or low-dose hydrocortisone (0...
February 21, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29467433/trend-and-risk-factors-of-low-birth-weight-and-macrosomia-in-south-china-2005-2017-a-retrospective-observational-study
#20
Jiaming Rao, Dazhi Fan, Shuzhen Wu, Dongxin Lin, Huishan Zhang, Shaoxin Ye, Xin Luo, Lijuan Wang, Jianwei Yang, Minhui Pang, Jiayi Zhang, Qing Xia, Xiaoke Yang, Wen Wang, Yao Fu, Yan Liu, Xiaoling Guo, Zhengping Liu
The percentages of low birth weight (LBW) increased from 7.7% in 2005 to 11.3% in 2011 and declined to 8.1% in 2017. For very low birth weight (VLBW) individuals, the proportion declined -1.0% annually, from 2.5% in 2005 to 1.4% in 2017. Among moderately low birth weight (MLBW) individuals, the proportion first increased 12.8% annually, from 5.0% in 2005 to 9.3% in 2011, and then declined -3.8% annually, from 9.4% in 2011 to 7.0% in 2017. The percentages of macrosomia monotone decreased from 4.0% in 2005 to 2...
February 21, 2018: Scientific Reports
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