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Pregnant AND Vitamin A AND birth defect

Ammar Saadoon, Namasivayam Ambalavanan, Kurt Zinn, Ambika P Ashraf, Mark MacEwen, Teodora Nicola, Michelle V Fanucchi, William T Harris
Epidemiologic studies have linked gestational vitamin D deficiency to respiratory diseases, although mechanisms have not been defined. We hypothesized that antenatal vitamin D deficiency would impair airway development and alveolarization in a mouse model. We studied the effect of antenatal vitamin D deficiency by inducing it in pregnant mice and then compared lung development and function in their offspring to littermate controls. Postnatal vitamin D deficiency and sufficiency models from each group were also studied...
March 2017: American Journal of Respiratory Cell and Molecular Biology
Darya Akimova, Bogdan J Wlodarczyk, Ying Lin, M Elizabeth Ross, Richard H Finnell, Qiuying Chen, Steven S Gross
BACKGROUND: Valproic acid (VPA) is prescribed therapeutically for multiple conditions, including epilepsy. When taken during pregnancy, VPA is teratogenic, increasing the risk of several birth and developmental defects including neural tube defects (NTDs). The mechanism by which VPA causes NTDs remains controversial and how VPA interacts with folic acid (FA), a vitamin commonly recommended for the prevention of NTDs, remains uncertain. We sought to address both questions by applying untargeted metabolite profiling analysis to neural tube closure (NTC) stage mouse embryos...
January 30, 2017: Birth Defects Res
Sufang Wang, Xing Ge, Beibei Zhu, Yujie Xuan, Kun Huang, Erigene Rutayisire, Leijing Mao, Sanhuan Huang, Shuangqin Yan, Fangbiao Tao
Supplementation with folic acid (FA) was proven to prevent neural tube defects (NTDs) and was recommended worldwide before and during early pregnancy. However, much less is known regarding the role of FA after the 12th gestational week (GW). This study aimed to investigate the related effects of continued FA supplementation after the first trimester of pregnancy on fetal growth. The study subjects came from the Ma'anshan-Anhui Birth Cohort Study (MABC) that recruited 3474 pregnant women from the city of Ma'anshan in Anhui Province in China during the period of May 2013 to September 2014...
August 15, 2016: Nutrients
Richard I Lowensohn, Diane D Stadler, Christie Naze
BACKGROUND: A nutrient-rich maternal diet before and during pregnancy is associated with improved fetal health, more appropriate birth weight, and increased rates of maternal and infant survival. Physicians need a better understanding of the role of diet in shaping fetal outcomes. Given this background, we reviewed and summarized articles on maternal nutrition found in MEDLINE since 1981, written in English, and limited to human subjects. FOR THE OFFSPRING: Maternal diets high in sugar and fat lead to an increased incidence of metabolic syndrome, diabetes, and cardiovascular disease later in life...
August 2016: Obstetrical & Gynecological Survey
Jan Beyer-Westendorf, Franziska Michalski, Luise Tittl, Saskia Middeldorp, Hannah Cohen, Rezan Abdul Kadir, Deepa Jayakody Arachchillage, Roopen Arya, Cihan Ay, Sandra Marten
Today, direct oral anticoagulants (DOAC) are widely used alternatives to Vitamin-K antagonists (VKA). Women of reproductive age may become pregnant during anticoagulation and, while VKA carry an embryotoxic potential, the risk of DOAC embryopathy is unknown. As a result, some patients elect to terminate pregnancy for fear of DOAC embryotoxicity. To assess the risk of DOAC embryopathy, we reviewed cases of DOAC exposure in pregnancy collected from physicians, literature and pharmacovigilance systems of drug authorities and manufacturers...
September 27, 2016: Thrombosis and Haemostasis
Gail C Rampersaud, Andrew Sokolow, Abigail Gruspe, James C Colee, Gail P A Kauwell
OBJECTIVE: To evaluate the impact of educational text messages (TMs) on folate/folic acid knowledge and consumption among college-aged women, and to evaluate the impact of providing folic acid supplements on folate/folic acid intake among college-aged women. PARTICIPANTS: A total of 162 women (18-24 years) recruited from a university. METHODS: The protocol included 3 study visits and a 6-week intervention for 4 groups: control; TM only; supplement only; and TM+supplement...
August 2016: Journal of American College Health: J of ACH
Kaouther Nasri, Mohamed Kacem Ben Fradj, Asma Touati, Mariem Aloui, Nadia Ben Jemaa, Aida Masmoudi, Michèle Véronique Elmay, Souhail Omar, Moncef Feki, Naziha Kaabechi, Raja Marrakchi, Soumeya Siala Gaigi
BACKGROUND: This study was conducted to determine whether low folate and vitamin B12 levels, as well as high homocysteine levels in pregnant women are associated with neural tube defects (NTDs) in Tunisia. METHODS: A total of 75 NTDs pregnancies and 75 matched controls were included in the study. Their vitamin B12, folate, and red blood cell folate concentrations were measured using a radio-immunoassay kit and total homocysteine concentrations were determined using a fluorescent polarization immunoassay...
December 2015: Birth Defects Research. Part A, Clinical and Molecular Teratology
Mortada H El-Shabrawi, Naglaa Mohamed Kamal, Mona Abbas Elhusseini, Laila Hussein, Enas Abdallah Ali Abdallah, Yahia Zakaria Abdelalim Ali, Ahmed Abelfattah Azab, Mostafa Abdelazim Salama, Muna Kassab, Michael Krawinkel
Neural tube defects (NTDs) are a group of congenital malformations with worldwide distribution and complex etiopathogenesis. Folic acid plays a pivotal role in their prevention. We aimed to identify the protective effect of folic acid intake against NTDs and its dependence on different socioeconomic and environmental factors in a cohort of mothers in Egypt. A cross-sectional study was carried over a period of 12 months on mothers who gave birth to babies with NTDs (group 1) and a control group with healthy offsprings (group 2)...
September 2015: Medicine (Baltimore)
R Douglas Wilson, R Douglas Wilson, François Audibert, Jo-Ann Brock, June Carroll, Lola Cartier, Alain Gagnon, Jo-Ann Johnson, Sylvie Langlois, Lynn Murphy-Kaulbeck, Nanette Okun, Melanie Pastuck, Paromita Deb-Rinker, Linda Dodds, Juan Andres Leon, Hélène L Lowel, Wei Luo, Amanda MacFarlane, Rachel McMillan, Aideen Moore, William Mundle, Deborah O'Connor, Joel Ray, Michiel Van den Hof
OBJECTIVE: To provide updated information on the pre- and post-conception use of oral folic acid with or without a multivitamin/micronutrient supplement for the prevention of neural tube defects and other congenital anomalies. This will help physicians, midwives, nurses, and other health care workers to assist in the education of women about the proper use and dosage of folic acid/multivitamin supplementation before and during pregnancy. EVIDENCE: Published literature was retrieved through searches of PubMed, Medline, CINAHL, and the Cochrane Library in January 2011 using appropriate controlled vocabulary and key words (e...
June 2015: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Tirso Pérez Medina, Nuria de Argila Fernández-Durán, Augusto Pereira Sánchez, Lucía Serrano González
Beer is a natural beverage low calorie, low degree of alcohol, no fats or sugars and a significant amount of carbohydrates, vitamins, and proteins. Beneficial health qualities are based on the presence in the beer of antioxidant compounds (polyphenols), which reduce the presence of free radicals in the organism, and phytoestrogens, elements biosimilars to natural estrogens. In pregnant women, beer, obviously alcohol-free, presents elements in its composition that differ it from other fermented beverages as it is the folic acid, vitamin necessary to prevent defects of the neural tube in the fetus or regulate homocysteine...
July 18, 2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Lucia L Kaiser, Christina G Campbell
It is the position of the Academy of Nutrition and Dietetics that women of childbearing age should adopt a lifestyle optimizing health and reducing risk of birth defects, suboptimal fetal development, and chronic health problems in both mother and child.Components leading to healthy pregnancy outcome include healthy pre-pregnancy weight, appropriate weight gain and physical activity during pregnancy, consumption of a wide variety of foods, appropriate vitamin and mineral supplementation, avoidance of alcohol and other harmful substances, and safe food handling...
September 2014: Journal of the Academy of Nutrition and Dietetics
Ines Banjari, Vlatka Matoković, Vedrana Škoro
UNLABELLED: PREGNANCY AND FOLIC ACID: Pregnancy is the most important period in life of every woman, partially for the number of physiological adaptations she is going through, partially for the expectance of new life. In addition, pregnancy is the "critical window" for development later in childhood, as a period of foetal programming during which nutrition plays one of crucial roles. Despite the general belief that nutrition through pregnancy is adequate and characterized by better nutritional habits, a number of studies do not corroborate this belief...
September 2014: Medicinski Pregled
Sahar A Ibrahim Hammouda, Om Alsaad Farouk Abd Al-Halim, Ahmed M Mohamadin
BACKGROUND/OBJECTIVES: Various studies have linked vitamin deficiencies in early pregnancy with birth defects. The objective of this study was to identify the relationship between micronutrient deficiency and congenital malformations (CM). SUBJECTS AND METHODS: There were 1,180 healthy, first-trimester pregnant Saudi-Arabian females selected from the antenatal care clinics of two hospitals and 21 health care centers located all over the city. Their full medical history, clinical examination, anthropometry, and various laboratory analyses were completed...
2013: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
James C Huhta, Kersti Linask
PURPOSE OF REVIEW: Provide a rationale for attempting prevention of congenital heart defects (CHDs). RECENT FINDINGS: Prevention of neural-tube defects can be achieved with preconceptional use of folic acid. Extrapolating results from animal studies to human pregnancy shows that folate deficiency as well as one-time exposure to environmental factors in the first 2 to 3 weeks of human gestation can result in severe CHD. Considering that approximately 50% of pregnancies are unplanned, this period of pregnancy can be considered high risk for cardiac, as well as neural, birth defects, as the woman usually is not aware of her pregnancy and may not yet be taking precautionary actions to protect the developing embryo...
January 2015: Current Opinion in Cardiology
Goele Jans, Isabelle Guelinckx, Willy Voets, Sander Galjaard, Paul M M Van Haard, Greet M Vansant, Roland Devlieger
BACKGROUND: Neonatal intracranial bleedings and birth defects have been reported, possibly related to maternal vitamin K1 deficiency during pregnancy after bariatric surgery. The objective of this study was to investigate the effects of screening and supplementation on K1 serum levels in pregnant women with bariatric surgery, and to compare K1 levels and prothrombin time (PT %) in the first trimester with pregnant women without bariatric surgery. METHODS: A prospective cohort study including 49 pregnant women with bariatric surgery...
September 2014: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Renata Bortolus, Fenneke Blom, Francesca Filippini, Mireille N M van Poppel, Emanuele Leoncini, Denhard J de Smit, Pier Paolo Benetollo, Martina C Cornel, Hermien E K de Walle, Pierpaolo Mastroiacovo
BACKGROUND: In 2010 a Cochrane review confirmed that folic acid (FA) supplementation prevents the first- and second-time occurrence of neural tube defects (NTDs). At present some evidence from observational studies supports the hypothesis that FA supplementation can reduce the risk of all congenital malformations (CMs) or the risk of a specific and selected group of them, namely cardiac defects and oral clefts. Furthermore, the effects on the prevention of prematurity, foetal growth retardation and pre-eclampsia are unclear...
May 13, 2014: BMC Pregnancy and Childbirth
Leslie deRosset, Amy Mullenix, Alina Flores, Daniel Mattia-Dewey, Cara T Mai
BACKGROUND: The U.S. Public Health Service recommends that all women in the United States capable of becoming pregnant consume 400 μg of folic acid daily to reduce their risk of having a pregnancy affected by a neural tube defect (NTD). However, disparities exist in the consumption of folic acid, with Hispanic women having lower rates of folic acid consumption than non-Hispanic white women. METHODS: A community-based feasibility study was designed to assess the utility of the promotora de salud model to promote consumption of multivitamins containing folic acid for the prevention of NTDs among Spanish-speaking Hispanic women in North Carolina...
June 2014: Journal of Women's Health
Yi Chi, Lijun Pei, Gong Chen, Xinming Song, Aihua Zhao, Tianlu Chen, Mingming Su, Yinan Zhang, Jianmeng Liu, Aiguo Ren, Xiaoying Zheng, Guoxiang Xie, Wei Jia
Neural tube defects (NTDs) are one of the most common types of birth defects with a complex etiology. We have previously profiled serum metabolites of pregnant women in Lvliang prefecture, Shanxi Province of China, which revealed distinct metabolic changes in pregnant women with NTDs outcome. Here we present a metabonomics study of human placentas of 144 pregnant women with normal pregnancy outcome and 115 pregnant women affected with NTDs recruited from four rural counties (Pingding, Xiyang, Taigu, and Zezhou) of Shanxi Province, the area with the highest prevalence worldwide...
February 7, 2014: Journal of Proteome Research
Agnieszka Seremak-Mrozikiewicz
Proper folate supplementation is required in order to ensure proper folate concentration in the organism, and consequently to prevent the development of numerous complications in general population and pregnant women. Metafolin (stable calcium salt of L-5-methyltetrahydrofolate acid, L-5-MTHF) is the most active form of reduced folate circulating in plasma, which directly enters the metabolic process of folate. After administration metafolin shows optimum absorption, comparable or higher bioavailability as well as physiological activity when compared to folic acid...
July 2013: Ginekologia Polska
Verena Sengpiel, Jonas Bacelis, Ronny Myhre, Solveig Myking, Aase Devold Pay, Margaretha Haugen, Anne-Lise Brantsæter, Helle Margrete Meltzer, Roy M Nilsen, Per Magnus, Stein Emil Vollset, Staffan Nilsson, Bo Jacobsson
BACKGROUND: Health authorities in numerous countries recommend periconceptional folic acid to pregnant women to prevent neural tube defects. The objective of this study was to examine the association of folic acid supplementation during different periods of pregnancy and of dietary folate intake with the risk of spontaneous preterm delivery (PTD). METHODS: The Norwegian Mother and Child Cohort Study is a population-based prospective cohort study. A total of 65,668 women with singleton pregnancies resulting in live births in 1999-2009 were included...
2013: BMC Pregnancy and Childbirth
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