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https://www.readbyqxmd.com/read/28720363/burden-of-urolithiasis-trends-in-prevalence-treatments-and-costs
#1
REVIEW
Omer A Raheem, Yash S Khandwala, Roger L Sur, Khurshid R Ghani, John D Denstedt
CONTEXT: The recent evolution of management options for urolithiasis has presented a unique dilemma for the modern urologist. A comprehensive understanding of epidemiological trends along with current provider preferences in treating urinary stones would be beneficial. OBJECTIVE: To review trends in the prevalence, treatments, and costs of urolithiasis worldwide. EVIDENCE ACQUISITION: A literature review was performed using the MEDLINE database, the Cochrane Library Central search facility, Web of Science, and Google Scholar between 1986 and 2016...
February 2017: European Urology Focus
https://www.readbyqxmd.com/read/28713073/dementia-friendly-interventions-to-improve-the-care-of-people-living-with-dementia-admitted-to-hospitals-a-realist-review
#2
Melanie Handley, Frances Bunn, Claire Goodman
OBJECTIVES: To identify features of programmes and approaches to make healthcare delivery in secondary healthcare settings more dementia-friendly, providing a context-relevant understanding of how interventions achieve outcomes for people living with dementia. DESIGN: A realist review conducted in three phases: (1) stakeholder interviews and scoping of the literature to develop an initial programme theory for providing effective dementia care; (2) structured retrieval and extraction of evidence; and (3) analysis and synthesis to build and refine the programme theory...
July 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28705239/nap-the-network-analysis-profiler-a-web-tool-for-easier-topological-analysis-and-comparison-of-medium-scale-biological-networks
#3
Theodosios Theodosiou, Georgios Efstathiou, Nikolas Papanikolaou, Nikos C Kyrpides, Pantelis G Bagos, Ioannis Iliopoulos, Georgios A Pavlopoulos
OBJECTIVE: Nowadays, due to the technological advances of high-throughput techniques, Systems Biology has seen a tremendous growth of data generation. With network analysis, looking at biological systems at a higher level in order to better understand a system, its topology and the relationships between its components is of a great importance. Gene expression, signal transduction, protein/chemical interactions, biomedical literature co-occurrences, are few of the examples captured in biological network representations where nodes represent certain bioentities and edges represent the connections between them...
July 14, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28696944/mitoriboscins-mitochondrial-based-therapeutics-targeting-cancer-stem-cells-cscs-bacteria-and-pathogenic-yeast
#4
Bela Ozsvari, Marco Fiorillo, Gloria Bonuccelli, Anna Rita Cappello, Luca Frattaruolo, Federica Sotgia, Rachel Trowbridge, Richard Foster, Michael P Lisanti
The "endo-symbiotic theory of mitochondrial evolution" states that mitochondrial organelles evolved from engulfed aerobic bacteria, after millions of years of symbiosis and adaptation. Here, we have exploited this premise to design new antibiotics and novel anti-cancer therapies, using a convergent approach. First, virtual high-throughput screening (vHTS) and computational chemistry were used to identify novel compounds binding to the 3D structure of the mammalian mitochondrial ribosome. The resulting library of ~880 compounds was then subjected to phenotypic drug screening on human cancer cells, to identify which compounds functionally induce ATP-depletion, which is characteristic of mitochondrial inhibition...
July 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28657446/observed-adducts-on-positive-mode-direct-analysis-in-real-time-mass-spectrometry-proton-ammonium-adduct-selectivities-of-600-sample-in-house-chemical-library
#5
Natsuhiko Sugimura, Asami Furuya, Takahiro Yatsu, Yoko Igarashi, Reiko Aoyama, Chisato Izutani, Yorihiro Yamamoto, Toshimichi Shibue
In this study, direct analysis in real time adduct selectivities of a 558 in-house high-resolution mass spectrometry sample library was evaluated. The protonated molecular ion ([M + H](+)) was detected in 462 samples. The ammonium adduct ion ([M + NH4](+)) was also detected in 262 samples. [M + H](+) and [M + NH4](+) molecular ions were observed simultaneously in 166 samples. These adduct selectivities were related to the elemental compositions of the sample compounds. [M + NH4](+) selectivity correlated with the number of oxygen atom(s), whereas [M + H](+) selectivity correlated with the number of nitrogen atom(s) in the elemental compositions...
February 2017: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/28611542/protecting-effects-of-gonadotropin-releasing-hormone-agonist-on-chemotherapy-induced-ovarian-damage-in-premenopausal-breast-cancer-patients-a-systematic-review-and-meta-analysis
#6
REVIEW
Fang Bai, Yunshu Lu, Kejin Wu, Qing Chen, Longlong Ding, Meixin Ge, Ziyi Weng
OBJECTIVE: There is no universal consensus on whether gonadotropin-releasing hormone (GnRH) agonist could protect chemotherapy-induced ovarian damage in premenopausal breast cancer patients. This meta-analysis was conducted to estimate the protective effects of GnRH agonist on premenopausal breast cancer patients in details. METHODS: PubMed, Cochrane Library, Embase, CNKI and the Chinese Wangfang Database, conference proceedings and clinical trials were searched to find studies reported since 2000...
March 2017: Breast Care
https://www.readbyqxmd.com/read/28596746/a-systematic-review-of-psychosocial-interventions-to-cancer-caregivers
#7
REVIEW
Fang Fu, Huaijuan Zhao, Feng Tong, Iris Chi
Objective: To systematically review the effect of psychosocial interventions on improving QoL, depression and anxiety of cancer caregivers. Methods: We conducted a systematic review of psychosocial interventions among adult cancer caregivers published from 2011 to 2016. PsycINFO, PubMed, Proquest, Cochrane Library, Embase, Applied Social Sciences Index and Abstracts (ASSIA), Cumulative Index to Nursing and Allied Health Literature, Social Sciences Citation Index (SSCI) and EBSCO, China National Knowledge Infrastructure (CNKI) and WANFANG were searched...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28580470/new-insights-into-the-chemistry-of-ionic-alkylorganic-carbonates-a-computational-study
#8
Khaleel I Assaf, Abdussalam K Qaroush, Ala'a F Eftaiha
A library of hydrogenated, perfluorinated aliphatic and aromatic (p-substituted) alcohols are selected together with a combination of superbases (SBs) and metal hydrides (MHs) to understand the thermodynamic parameters of the binary mixtures once serving as sorbents for the capture of CO2via ionic organic alkyl-carbonate (RCO3(-)) formation. Data are obtained using density functional theory (DFT) calculations with the B3LYP/6-31+G* level of theory and compared with the experimental results acquired from the literature using different spectroscopic techniques...
June 14, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28579712/level-of-awareness-and-knowledge-of-breast-cancer-in-nigeria-a-systematic-review
#9
REVIEW
Agodirin S Olayide, Akande J Halimat, Olatoke A Samuel, Rahman A Ganiyu, Oguntola A Soliu
BACKGROUND: Despite reports of improved awareness of breast cancer entity and seemingly upbeat levels of other awareness subthemes in Nigeria, patients continue to present late when treatment is least rewarding. This paradoxical trend of both rising awareness and late presentation coupled with reports suggesting other competing drivers of late presentation question the "theory of poor awareness" as the foremost driver of late presentations. By aggregating available data, we aimed to assess what still constitutes poor breast cancer awareness in Nigeria in order to suggest how to allocate resources to reverse the paradox...
March 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/28573250/the-use-of-rheum-palmatum-l-in-the-treatment-of-acute-respiratory-distress-syndrome-a-meta-analysis-of-randomized-controlled-trials
#10
Tie-Zhu Yang, Yan Liu, Yue-Yun Liu, Xiu-Fang Ding, Jia-Xu Chen, Mei-Jing Kou, Xiao-Juan Zou
BACKGROUND: Chinese medicine theory shows that "lung being connected with large intestine", and the modern western medicine also shows that the lung and intestinal tract affect each other in physiological and pathological conditions. If the lung ventilation dysfunction is caused by inflammatory exudate or secretions obstruction of the small airway ventilation, blood gas partial pressure is increased and intestinal gas absorption difficulty may lead to intestinal inflation and dysfunction (Wang N et al...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28564546/polyurethane-microgel-based-microtissue-interface-guided-assembly-and-spreading
#11
Michael J Hill, Debanjan Sarkar
Colloidal gels are three-dimensional networks of microgel particles and can be utilized to design microtissues where the differential adhesive interactions between the particles and cells, guided by their surface energetics, are engineered to spatially assemble the cellular and colloidal components into three-dimensional microtissues. In this work we utilized a colloidal interaction approach to design cell-polyurethane (PU) microgel bimodal microtissues using endothelial cells (ECs) as a normal cell model and a nonmalignant breast cancer cell line (MCF-7) as a cancer cell model...
June 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28550009/digital-support-interventions-for-the-self-management-of-low-back-pain-a-systematic-review
#12
Barbara I Nicholl, Louise F Sandal, Mette J Stochkendahl, Marianne McCallum, Nithya Suresh, Ottar Vasseljen, Jan Hartvigsen, Paul J Mork, Per Kjaer, Karen Søgaard, Frances S Mair
BACKGROUND: Low back pain (LBP) is a common cause of disability and is ranked as the most burdensome health condition globally. Self-management, including components on increased knowledge, monitoring of symptoms, and physical activity, are consistently recommended in clinical guidelines as cost-effective strategies for LBP management and there is increasing interest in the potential role of digital health. OBJECTIVE: The study aimed to synthesize and critically appraise published evidence concerning the use of interactive digital interventions to support self-management of LBP...
May 21, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28531346/projector-augmented-wave-method-incorporated-into-gauss-type-atomic-orbital-based-density-functional-theory
#13
Xiao-Gen Xiong, Takeshi Yanai
The Projector Augmented Wave (PAW) method developed by Blöchl is well recognized as an efficient, accurate pseudopotential approach in solid-state density functional theory (DFT) calculations with the plane-wave basis. Here we present an approach to incorporate the PAW method into the Gauss-type function (GTF) based DFT implementation, which is widely used for molecular quantum chemistry calculations. The nodal and high-exponent GTF components of valence molecular orbitals (MOs) are removed or pseudized by the ultrasoft PAW treatment, while there is elaborate transparency to construct an accurate and well-controlled pseudopotential from all-electron atomic description and to reconstruct an all-electron form of valence MOs from the pseudo MOs...
June 9, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28511609/why-the-history-of-nursing-ethics-matters
#14
Marsha D Fowler
Modern American nursing has an extensive ethical heritage literature that extends from the 1870s to 1965 when the American Nurses Association issued a policy paper that called for moving nursing education out of hospital diploma programs and into colleges and universities. One consequence of this move was the dispersion of nursing libraries and the loss of nursing ethics textbooks, as they were largely not brought over into the college libraries. In addition to approximately 100 nursing ethics textbooks, the nursing ethics heritage literature also includes hundreds of journal articles that are often made less accessible in modern databases that concentrate on the past 20 or 30 years...
May 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28489372/psi4-1-1-an-open-source-electronic-structure-program-emphasizing-automation-advanced-libraries-and-interoperability
#15
Robert M Parrish, Lori A Burns, Daniel G A Smith, Andrew C Simmonett, A Eugene DePrince, Edward G Hohenstein, Uğur Bozkaya, Alexander Yu Sokolov, Roberto Di Remigio, Ryan M Richard, Jérôme F Gonthier, Andrew M James, Harley R McAlexander, Ashutosh Kumar, Masaaki Saitow, Xiao Wang, Benjamin P Pritchard, Prakash Verma, Henry F Schaefer, Konrad Patkowski, Rollin A King, Edward F Valeev, Francesco A Evangelista, Justin M Turney, T Daniel Crawford, C David Sherrill
Psi4 is an ab initio electronic structure program providing methods such as Hartree-Fock, density functional theory, configuration interaction, and coupled-cluster theory. The 1.1 release represents a major update meant to automate complex tasks, such as geometry optimization using complete-basis-set extrapolation or focal-point methods. Conversion of the top-level code to a Python module means that Psi4 can now be used in complex workflows alongside other Python tools. Several new features have been added with the aid of libraries providing easy access to techniques such as density fitting, Cholesky decomposition, and Laplace denominators...
June 6, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28482322/do-e-health-interventions-improve-physical-activity-in-young-people-a-systematic-review
#16
REVIEW
J R D McIntosh, S Jay, N Hadden, P J Whittaker
OBJECTIVES: This study aims to review the current literature to assess the effectiveness of E-health interventions in increasing physical activity (PA) in young people. STUDY DESIGN: This study is a systematic review of the literature. METHODS: A search of the literature databases Embase, MEDLINE and the Cochrane Library using key words 'Adolescents'; 'Young people'; 'Students'; 'Young Adults'; 'Teenagers'; 'E-health'; 'Internet-based'; 'Web-based'; 'Exercise'; 'Activity'; 'Sport' and 'Intervention' yielded 10 articles which fit the criteria for inclusion...
July 2017: Public Health
https://www.readbyqxmd.com/read/28474374/mobile-phone-messaging-for-illicit-drug-and-alcohol-dependence-a-systematic-review-of-the-literature
#17
Babak Tofighi, Joseph M Nicholson, Jennifer McNeely, Frederick Muench, Joshua D Lee
ISSUES: Mobile phone use has increased dramatically and concurrent with rapid developments in mobile phone-based health interventions. The integration of text messaging interventions promises to optimise the delivery of care for persons with substance dependence with minimal disruption to clinical workflows. We conducted a systematic review to assess the acceptability, feasibility and clinical impact of text messaging interventions for persons with illicit drug and alcohol dependence...
May 5, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28464325/optimizing-staffing-quality-and-cost-in-home-healthcare-nursing-theory-synthesis
#18
Claire Su-Yeon Park
AIMS: To propose a new theory pinpointing the optimal nurse staffing threshold delivering the maximum quality of care relative to attendant costs in home health care. BACKGROUND: Little knowledge exists on the theoretical foundation addressing the inter-relationship among quality of care, nurse staffing, and cost. DESIGN: Theory synthesis. DATA SOURCES: Cochrane Library, PubMed, CINAHL, EBSCOhost Web and Web of Science (25 February - 26 April 2013; 20 January - 22 March 2015)...
May 2, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28425568/libkedf-an-accelerated-library-of-kinetic-energy-density-functionals
#19
Johannes M Dieterich, William C Witt, Emily A Carter
Kinetic energy density functionals (KEDFs) approximate the kinetic energy of a system of electrons directly from its electron density. They are used in electronic structure methods that lack direct access to orbitals, for example, orbital-free density functional theory (OFDFT) and certain embedding schemes. In this contribution, we introduce libKEDF, an accelerated library of modern KEDF implementations that emphasizes nonlocal KEDFs. We discuss implementation details and assess the performance of the KEDF implementations for large numbers of atoms...
April 20, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28422704/influencing-factors-on-high-risk-sexual-behaviors-in-young-people-an-ecological-perspective
#20
Hoda Arabi-Mianrood, Zeinab Hamzehgardeshi, Elham Khoori, Mahmood Moosazadeh, Zohreh Shahhosseini
Background In recent years, high-risk sexual behaviors due to their negative consequences both for the individual and society have received more attention than other high-risk behaviors. Objective The aim of this study was to review the influencing factors of high-risk sexual behaviors among young people from an ecological point of view. Methods This review was conducted through searching databases including PubMed, Web of Science, Scopus, Google Scholar and the Cochrane Library with keywords such as sexual risk-taking behavior, high-risk sex, unprotected sex and unsafe sex...
April 19, 2017: International Journal of Adolescent Medicine and Health
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