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https://www.readbyqxmd.com/read/28327656/synthesis-of-norbornene-derived-helical-copolymer-by-simple-molecular-marriage-approach-to-produce-smart-nanocarrier
#1
Shivshankar R Mane, Ashlin Sathyan, Raja Shunmugam
A novel library of norbornene derived helical copolymer has been synthesized through the coupling of two homopolymers via Molecular Marriage Approach. The helicity is governed by the non-covalent interactions like hydrogen bonding, π-π stacking and the influence of hydrophobic and hydrophilic motifs. The detailed characterization of the copolymer (Copoly 1) has been provided and the super structures are confirmed through dynamic light scattering (DLS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM)...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28288597/school-based-vaccination-programmes-a-systematic-review-of-the-evidence-on-organisation-and-delivery-in-high-income-countries
#2
Sarah Perman, Simon Turner, Angus I G Ramsay, Abigail Baim-Lance, Martin Utley, Naomi J Fulop
BACKGROUND: Many countries have recently expanded their childhood immunisation programmes. Schools are an increasingly attractive setting for delivery of these new immunisations because of their ability to reach large numbers of children in a short period of time. However, there are organisational challenges to delivery of large-scale vaccination programmes in schools. Understanding the facilitators and barriers is important for improving the delivery of future school-based vaccination programmes...
March 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28287689/analysis-of-current-dna-encoded-library-screening-data-indicates-higher-false-negative-rates-for-numerically-larger-libraries
#3
Alexander L Satz, Remo Hochstrasser, Ann C Petersen
To optimize future DNA encoded library design, we have attempted to quantify the library size at which signal becomes undetectable. To accomplish this we i) have calculated that percent yields of individual library members following a screen range from 0.002-1%, ii) extrapolated that ~ 1 million copies per library member are required at the outset of a screen, and iii) from this extrapolation predict that false negative rates will begin to outweigh the benefit of increased diversity at library sizes >108...
March 13, 2017: ACS Combinatorial Science
https://www.readbyqxmd.com/read/28285521/exploring-covalent-allosteric-inhibition-of-antigen-85c-from-mycobacterium-tuberculosis-by-ebselen-derivatives
#4
Christopher M Goins, Steven J Dajnowicz, Sandeep Thanna, Steven J Sucheck, Jerry Matthew Parks, Donald R Ronning
Previous studies identified ebselen as a potent in vitro and in vivo inhibitor of the Mycobacterium tuberculosis (Mtb) antigen 85 (Ag85) complex, comprising three homologous enzymes required for the biosynthesis of the mycobacterial cell wall. In this study, the Mtb Ag85C enzyme was co-crystallized with azido and adamantyl ebselen derivatives, resulting in two crystallographic structures of 2.01 and 1.30 Å resolution, respectively. Both structures displayed the anticipated covalent modification of the solvent accessible, non-catalytic Cys209 residue forming a selenenylsulfide bond...
March 13, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28252908/the-experience-of-educational-quality-in-undergraduate-nursing-students-a-phenomenological-study
#5
Loreana Macale, Ercole Vellone, Gennaro Scialò, Mauro Iossa, Elena Cristofori, Rosaria Alvaro
AIM: The evaluation of academic education has become crucial in the European Union since the Bologna Process encouraged all European universities to reach high quality standards in education. Although several studies have been conducted on the quality of undergraduate nursing education, few studies have explored this topic from the students' perspective. The purpose of this study was to describe the experience of educational quality in undergraduate nursing students. METHOD: The phenomenological method was used to study 55 students (mean age 24 years; 73% female) pursuing a baccalaureate degree in nursing in three universities in central Italy...
October 2016: Professioni Infermieristiche
https://www.readbyqxmd.com/read/28248628/cultural-and-linguistic-adaptation-of-a-healthy-diet-text-message-intervention-for-hispanic-adults-living-in-the-united-states
#6
Linda D Cameron, Arturo Durazo, A Susana Ramírez, Roberto Corona, Mayra Ultreras, Sonia Piva
Hispanics represent a critical target for culturally adapted diet interventions. In this formative research, we translated HealthyYouTXT, an mHealth program developed by the U.S. National Cancer Institute, into HealthyYouTXT en Español, a linguistically and culturally appropriate version for Spanish speakers in the United States. We report a three-stage, mixed-methods process through which we culturally adapted the text messages, evaluated their acceptability, and revised the program based on the findings...
March 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28241771/use-of-theory-to-plan-or-evaluate-guideline-implementation-among-physicians-a-scoping-review
#7
REVIEW
Laurel Liang, Susanne Bernhardsson, Robin W M Vernooij, Melissa J Armstrong, André Bussières, Melissa C Brouwers, Anna R Gagliardi
BACKGROUND: Guidelines support health care decision-making and high quality care and outcomes. However, their implementation is sub-optimal. Theory-informed, tailored implementation is associated with guideline use. Few guideline implementation studies published up to 1998 employed theory. This study aimed to describe if and how theory is now used to plan or evaluate guideline implementation among physicians. METHODS: A scoping review was conducted. MEDLINE, EMBASE, and The Cochrane Library were searched from 2006 to April 2016...
February 27, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28240533/surface-tension-components-ratio-an-efficient-parameter-for-direct-liquid-phase-exfoliation
#8
Man Wang, Xiaowei Xu, Yuancai Ge, Pei Dong, Robert Baines, Pulickel M Ajayan, Mingxin Ye, Jianfeng Shen
Direct liquid phase exfoliation (LPE) is generally regarded as an effective and efficient methodology for preparing single- to few-layered nanosheets on a large scale. Based on a previous finding that the polar and dispersive components of surface tension can be used as critical parameters for screening suitable solvents for LPE, in this study, we conducted in-depth research on direct LPE of two-dimensional (2D) materials by the extensive LPE of a series of 2D materials and the thorough comparison of their surfaces properties and LPE efficiencies...
March 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28185369/sensory-overload-a-concept-analysis
#9
REVIEW
Stefan Scheydt, Maria Müller Staub, Fritz Frauenfelder, Gunnar H Nielsen, Johann Behrens, Ian Needham
In the context of mental disorders sensory overload is a widely described phenomenon used in conjunction with psychiatric interventions such as removal from stimuli. However, the theoretical foundation of sensory overload as addressed in the literature can be described as insufficient and fragmentary. To date, the concept of sensory overload has not yet been sufficiently specified or analyzed. The aim of the study was to analyze the concept of sensory overload in mental health care. A literature search was undertaken using specific electronic databases, specific journals and websites, hand searches, specific library catalogues, and electronic publishing databases...
April 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/28162090/a-realist-review-of-mobile-phone-based-health-interventions-for-non-communicable-disease-management-in-sub-saharan-africa
#10
Daniel Opoku, Victor Stephani, Wilm Quentin
BACKGROUND: The prevalence of non-communicable diseases (NCDs) is increasing in sub-Saharan Africa. At the same time, the use of mobile phones is rising, expanding the opportunities for the implementation of mobile phone-based health (mHealth) interventions. This review aims to understand how, why, for whom, and in what circumstances mHealth interventions against NCDs improve treatment and care in sub-Saharan Africa. METHODS: Four main databases (PubMed, Cochrane Library, Web of Science, and Google Scholar) and references of included articles were searched for studies reporting effects of mHealth interventions on patients with NCDs in sub-Saharan Africa...
February 6, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28134445/interventions-for-prevention-of-bullying-in-the-workplace
#11
REVIEW
Patricia A Gillen, Marlene Sinclair, W George Kernohan, Cecily M Begley, Ans G Luyben
BACKGROUND: Bullying has been identified as one of the leading workplace stressors, with adverse consequences for the individual employee, groups of employees, and whole organisations. Employees who have been bullied have lower levels of job satisfaction, higher levels of anxiety and depression, and are more likely to leave their place of work. Organisations face increased risk of skill depletion and absenteeism, leading to loss of profit, potential legal fees, and tribunal cases. It is unclear to what extent these risks can be addressed through interventions to prevent bullying...
January 30, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28128950/naphthablins-b-and-c-meroterpenoids-identified-from-the-marine-sediment-derived-streptomyces-sp-cp26-58-using-hela-cell-based-cytological-profiling
#12
Hana Martucci, Scott E Campit, Stephanie R Gee, Walter M Bray, Trevor Gokey, A King Cada, Ten-Yang Yen, Katsuhiko Minoura, Anton B Guliaev, R Scott Lokey, Taro Amagata
HeLa cell-based cytological profiling (CP) was applied to an extract library of marine sediment-derived actinomycetes to discover new cytotoxic secondary metabolites. Among the hit strains, Streptomyces sp. CP26-58 was selected for further investigation to identify its cytotoxic metabolites. CP revealed that the known ionophore tetronasin (1) was responsible for the cytotoxic effect found in the extract. Furthermore, three naphthoquinone meroterpenoids, naphthablin A (2) and two new derivatives designated as naphthablins B (3) and C (4), were isolated from other cytotoxic fractions...
January 27, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28121021/interventions-for-dysarthria-due-to-stroke-and-other-adult-acquired-non-progressive-brain-injury
#13
REVIEW
Claire Mitchell, Audrey Bowen, Sarah Tyson, Zoe Butterfint, Paul Conroy
BACKGROUND: Dysarthria is an acquired speech disorder following neurological injury that reduces intelligibility of speech due to weak, imprecise, slow and/or unco-ordinated muscle control. The impact of dysarthria goes beyond communication and affects psychosocial functioning. This is an update of a review previously published in 2005. The scope has been broadened to include additional interventions, and the title amended accordingly. OBJECTIVES: To assess the effects of interventions to improve dysarthric speech following stroke and other non-progressive adult-acquired brain injury such as trauma, infection, tumour and surgery...
January 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28118011/a-general-sparse-tensor-framework-for-electronic-structure-theory
#14
Samuel Manzer, Evgeny Epifanovsky, Anna I Krylov, Martin Head-Gordon
Linear-scaling algorithms must be developed in order to extend the domain of applicability of electronic structure theory to molecules of any desired size. However, the increasing complexity of modern linear-scaling methods makes code development and maintenance a significant challenge. A major contributor to this difficulty is the lack of robust software abstractions for handling block-sparse tensor operations. We therefore report the development of a highly efficient symbolic block-sparse tensor library in order to provide access to high-level software constructs to treat such problems...
March 14, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28093364/fabrication-of-nanofibrous-electrospun-scaffolds-from-a-heterogeneous-library-of-co-and-self-assembling-peptides
#15
Mahboubeh Maleki, Antonino Natalello, Raffaele Pugliese, Fabrizio Gelain
Self-assembling (SAPs) and co-assembling peptides (CAPs) are driving increasing enthusiasm as synthetic but biologically inspired biomaterials amenable of easy functionalization for regenerative medicine. On the other hand, electrospinning (ES) is a versatile technique useful for tailoring the nanostructures of various biomaterials into scaffolds resembling the extracellular matrices found in organs and tissues. The synergistic merging of these two approaches is a long-awaited advance in nanomedicine that has not been deeply documented so far...
January 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28093049/efficient-variational-approach-to-multimodal-registration-of%C3%A2-anatomical%C3%A2-and%C3%A2-functional-intra-patient-tumorous-brain-data
#16
Alvar-Ginés Legaz-Aparicio, Rafael Verdú-Monedero, Jorge Larrey-Ruiz, Juan Morales-Sánchez, Fernando López-Mir, Valery Naranjo, Ángela Bernabéu
This paper addresses the functional localization of intra-patient images of the brain. Functional images of the brain (fMRI and PET) provide information about brain function and metabolism whereas anatomical images (MRI and CT) supply the localization of structures with high spatial resolution. The goal is to find the geometric correspondence between functional and anatomical images in order to complement and fuse the information provided by each imaging modality. The proposed approach is based on a variational formulation of the image registration problem in the frequency domain...
November 29, 2016: International Journal of Neural Systems
https://www.readbyqxmd.com/read/28035955/exon-shuffling-and-origin-of-scorpion-venom-biodiversity
#17
Xueli Wang, Bin Gao, Shunyi Zhu
Scorpion venom is a complex combinatorial library of peptides and proteins with multiple biological functions. A combination of transcriptomic and proteomic techniques has revealed its enormous molecular diversity, as identified by the presence of a large number of ion channel-targeted neurotoxins with different folds, membrane-active antimicrobial peptides, proteases, and protease inhibitors. Although the biodiversity of scorpion venom has long been known, how it arises remains unsolved. In this work, we analyzed the exon-intron structures of an array of scorpion venom protein-encoding genes and unexpectedly found that nearly all of these genes possess a phase-1 intron (one intron located between the first and second nucleotides of a codon) near the cleavage site of a signal sequence despite their mature peptides remarkably differ...
December 26, 2016: Toxins
https://www.readbyqxmd.com/read/28018650/using-fisher-information-to-track-stability-in-multivariate-systems
#18
Nasir Ahmad, Sybil Derrible, Tarsha Eason, Heriberto Cabezas
With the current proliferation of data, the proficient use of statistical and mining techniques offer substantial benefits to capture useful information from any dataset. As numerous approaches make use of information theory concepts, here, we discuss how Fisher information (FI) can be applied to sustainability science problems and used in data mining applications by analysing patterns in data. FI was developed as a measure of information content in data, and it has been adapted to assess order in complex system behaviour...
November 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27982169/primordial-and-primary-prevention-programs-for-cardiovascular-diseases-from-risk-assessment-through-risk-communication-to-risk-reduction-a-review-of-the-literature
#19
Inês Lancarotte, Moacyr Roberto Nobre
The aim of this study was to identify and reflect on the methods employed by studies focusing on intervention programs for the primordial and primary prevention of cardiovascular diseases. The PubMed, EMBASE, SciVerse Hub-Scopus, and Cochrane Library electronic databases were searched using the terms 'effectiveness AND primary prevention AND risk factors AND cardiovascular diseases' for systematic reviews, meta-analyses, randomized clinical trials, and controlled clinical trials in the English language. A descriptive analysis of the employed strategies, theories, frameworks, applied activities, and measurement of the variables was conducted...
November 1, 2016: Clinics
https://www.readbyqxmd.com/read/27943483/rapid-realist-review-of-the-evidence-achieving-lasting-change-when-mental-health-rehabilitation-staff-undertake-recovery-oriented-training
#20
REVIEW
M Gee, S Bhanbrho, S Cook, H Killaspy
AIM: To identify the factors contributing to lasting change in practice following a recovery-based training intervention for inpatient mental health rehabilitation staff. BACKGROUND: Staff training may help nurses and other staff groups in inpatient mental health rehabilitative settings to increase their recovery-oriented practice. There are no published reviews on the effectiveness of such training and few long-term evaluations. This review informed a realist evaluation of a specific intervention ('GetREAL')...
December 10, 2016: Journal of Advanced Nursing
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