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https://www.readbyqxmd.com/read/28214841/drug-dosing-and-estimated-renal-function-any-step-forward-from-effersoe
#1
Mads Hornum, Bo Feldt-Rasmussen
Drug dosing in accordance with the renal function is a long-standing challenge to clinicians. For many years it has been evident that in many clinical situations there is no easy way to correctly dose any drug that is mainly cleared by the kidneys. Despite the development of many formulas for estimating the glomerular filtration rate, they all have serious shortcomings. Much effort has been put in to develop estimation formulas to evaluate the renal function as an alternative to direct methods with the aim of safely dosing drugs that are mainly cleared by the kidneys...
February 18, 2017: Nephron
https://www.readbyqxmd.com/read/28213762/association-between-cognitive-impairment-and-urinary-dysfunction-in-parkinson-s-disease
#2
Zuzanna Tkaczynska, Andrea Pilotto, Sara Becker, Susanne Gräber-Sultan, Daniela Berg, Inga Liepelt-Scarfone
Urinary dysfunction (UD) is a common non-motor feature of Parkinson's disease (PD), and might be secondary to neurodegeneration involving cortical and subcortical brain areas. The possible link between UD and cognitive deficits has never been examined in frontal cortex impairment, and is still not completely understood in PD. In the present study, 94 PD patients underwent a comprehensive motor, cognitive and non-motor assessment. It was shown that 55.3% of patients reported UD, of which 17% needed specific urological treatment...
February 17, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28205497/critical-motor-involvement-in-prediction-of-human-and-non-biological-motion-trajectories
#3
Matthieu M de Wit, Laurel J Buxbaum
OBJECTIVES: Adaptive interaction with the environment requires the ability to predict both human and non-biological motion trajectories. Prior accounts of the neurocognitive basis for prediction of these two motion classes may generally be divided into those that posit that non-biological motion trajectories are predicted using the same motor planning and/or simulation mechanisms used for human actions, and those that posit distinct mechanisms for each. Using brain lesion patients and healthy controls, this study examined critical neural substrates and behavioral correlates of human and non-biological motion prediction...
February 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28205496/planning-functional-grasps-of-simple-tools-invokes-the-hand-independent-praxis-representation-network-an-fmri-study
#4
Łukasz Przybylski, Gregory Króliczak
OBJECTIVES: Neuropsychological and neuroimaging evidence indicates that tool use knowledge and abilities are represented in the praxis representation network (PRN) of the left cerebral hemisphere. We investigated whether PRN would also underlie the planning of function-appropriate grasps of tools, even though such an assumption is inconsistent with some neuropsychological evidence for independent representations of tool grasping and skilled tool use. METHODS: Twenty right-handed participants were tested in an event-related functional magnetic resonance imaging (fMRI) study wherein they planned functionally appropriate grasps of tools versus grasps of non-tools matched for size and/or complexity, and later executed the pantomimed grasps of these objects...
February 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28195027/the-anthropo-scene-a-guide-for-the-perplexed
#5
Jamie Lorimer
The scientific proposal that the Earth has entered a new epoch as a result of human activities - the Anthropocene - has catalysed a flurry of intellectual activity. I introduce and review the rich, inchoate and multi-disciplinary diversity of this Anthropo-scene. I identify five ways in which the concept of the Anthropocene has been mobilized: scientific question, intellectual zeitgeist, ideological provocation, new ontologies and science fiction. This typology offers an analytical framework for parsing this diversity, for understanding the interactions between different ways of thinking in the Anthropo-scene, and thus for comprehending elements of its particular and peculiar sociabilities...
February 2017: Social Studies of Science
https://www.readbyqxmd.com/read/28182172/chronic-disease-self-management-support-for-persons-with-dementia-in-a-clinical-setting
#6
Joseph Elias Ibrahim, Laura J Anderson, Aleece MacPhail, Janaka Jonathan Lovell, Marie-Claire Davis, Margaret Winbolt
The burden of chronic disease is greater in individuals with dementia, a patient group that is growing as the population is aging. The cornerstone of optimal management of chronic disease requires effective patient self-management. However, this is particularly challenging in older persons with a comorbid diagnosis of dementia. The impact of dementia on a person's ability to self-manage his/her chronic disease (eg, diabetes mellitus or heart failure) varies according to the cognitive domain(s) affected, severity of impairment and complexity of self-care tasks...
2017: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/28131207/the-correlation-between-cerebral-arterial-pulsatility-and-cognitive-dysfunction-in-alzheimer-s-disease-patients
#7
Jae-Sung Lim, Jee Young Lee, Hyung-Min Kwon, Yong-Seok Lee
BACKGROUND: Potential role of vascular dysfunction has been suggested in the pathogenesis of Alzheimer's disease (AD). Previous cross-sectional studies have demonstrated relations between abnormal transcranial Doppler (TCD) parameters and cognitive impairment. We aimed to investigate the associations between longitudinal changes of TCD parameters and cognitive decline in patients with AD. METHODS: We have enrolled patients with mild to moderate AD who aged 60 to 79years...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28128035/functional-plasticity-in-the-absence-of-structural-change
#8
Tal Krasovsky, Jana Landa, Orly Bar, Ahonniska-Assa Jaana, Abigail Livny, Galia Tsarfaty, Tamar Silberg
This work presents a case of a young woman with apraxia and a severe body scheme disorder, 10 years after a childhood frontal and occipitoparietal brain injury. Despite specific limitations, she is independent in performing all activities of daily living. A battery of tests was administered to evaluate praxis and body representations. Specifically, the Hand Laterality Test was used to compare RS's dynamic body representation to that of healthy controls (N = 14). Results demonstrated RS's severe praxis impairment, and the Hand Laterality Test revealed deficits in accuracy and latency of motor imagery, suggesting a significant impairment in dynamic body representation...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28107802/movement-kinematics-of-the-ipsilesional-upper-extremity-in-persons-with-moderate-or-mild-stroke
#9
Eva-Lena Bustrén, Katharina Stibrant Sunnerhagen, Margit Alt Murphy
BACKGROUND: An increasing number of studies have indicated that the ipsilesional arm may be impaired after stroke. There is, however, a lack of knowledge whether ipsilesional deficits influence movement performance during purposeful daily tasks. OBJECTIVE: The aim of this study was to investigate whether, and to what extent, movement impairments are present while performing an ipsilesional upper extremity task during the first 3 months after stroke. METHODS: Movement kinematics describing movement time, smoothness, velocity, strategy, and pattern were captured during a standardized drinking task in 40 persons with first-ever stroke and 20 controls...
January 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28092712/-global-bioethics-and-biocultural-ethics
#10
Ricardo Rozzi
The biocultural ethic recovers an understanding of the vital links between the life habits of the coinhabitants (humans and other-than-human) that share a habitat. The ″3Hs″ formal framework of the biocultural ethics provides a conceptual and methodological tool to understand and to better manage complex eco-social or biocultural systems in heterogeneous regions of the planet. From the global bioethics originally proposed by V.R. Potter, the integration of theory and praxis promoted by Alfredo Pradenas in the Bioethics Society of Chile, and the conceptual framework of biocultural ethics (including traditions of philosophical thought, scientific and Amerindians), I develop a comparative analysis of: 1...
September 2016: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/28074464/investigation-of-hand-function-among-children-diagnosed-with-autism-spectrum-disorder-with-upper-extremity-trauma-history
#11
Meral Huri, Sedef Şahin, Hülya Kayıhan
BACKGROUND: The present study was designed to compare hand function in autistic children with history of upper extremity trauma with that of autistic children those who do not have history of trauma. METHODS: The study group included total of 65 children diagnosed with autism spectrum disorder (ASD) and was divided into 2 groups: children with trauma history (Group I) and control group (Group II) (Group I: n=28; Group II: n=37). Hand function was evaluated with 9-Hole Peg Test and Jebsen Hand Function Test...
November 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28049217/-the-most-cited-articles-in-volume-41-of-psychiatrische-praxis-congratulations
#12
Philipp Reimann, Steffi G Riedel-Heller
No abstract text is available yet for this article.
January 2017: Psychiatrische Praxis
https://www.readbyqxmd.com/read/27965279/sex-differences-in-prodromal-symptoms-in-acute-coronary-syndrome-in-patients-aged-55%C3%A2-years-or-younger
#13
Nadia A Khan, Stella S Daskalopoulou, Igor Karp, Mark J Eisenberg, Roxanne Pelletier, Meytal Avgil Tsadok, Kaberi Dasgupta, Colleen M Norris, Louise Pilote
BACKGROUND: Studies suggest that young women are at highest risk for failing to recognise early symptoms of acute coronary syndrome (ACS). OBJECTIVES: To examine sex differences in prodromal symptoms occurring days and weeks prior to the acute presentation of ACS. We also examined health-seeking behaviours and prehospital management in young patients. METHODS: Prospective cross-sectional analysis of 1145 patients (368 women) hospitalised for ACS, aged ≤55 years, from the GENdEr and Sex DetermInantS of Cardiovascular Disease: From Bench to Beyond Premature Acute Coronary SYndrome cohort study (January 2009-April 2013)...
December 13, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27964726/cognition-in-chronic-kidney-disease-a-systematic-review-and-meta-analysis
#14
Israel Berger, Sunny Wu, Philip Masson, Patrick J Kelly, Fiona A Duthie, William Whiteley, Daniel Parker, David Gillespie, Angela C Webster
BACKGROUND: Cognitive impairment is common in people with chronic kidney disease (CKD) and associated with increased morbidity and mortality. Subtle changes can impact engagement with healthcare, comprehension, decision-making, and medication adherence. We aimed to systematically summarise evidence of cognitive changes in CKD. METHODS: We searched MEDLINE (March 2016) for cross-sectional, cohort or randomised studies that measured cognitive function in people with CKD (PROSPERO, registration number CRD42014015226)...
December 14, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27930399/practical-discourse-revisited-hermeneutics-at-the-intersection-of-philosophy-and-nursing
#15
Stephen M Padgett
Three early papers by Janice Thompson-Practical Discourse, Critical Scholarship, and Hermeneutic Inquiry-are examined in reference to the historical context of the time (1985-1990), and implications for current scholarship. Hermeneutic philosophy has been neglected in recent years, overshadowed by its weaker cousin phenomenology. I argue that renewed attention to hermeneutics would help us focus on the "situatedness" of nursing scholars, the class politics of academia, and a better balance in interpretative work between faith and suspicion...
January 2017: ANS. Advances in Nursing Science
https://www.readbyqxmd.com/read/27929229/the-mental-status-examination
#16
David Norris, Molly S Clark, Sonya Shipley
The mental status examination includes general observations made during the clinical encounter, as well as specific testing based on the needs of the patient and physician. Multiple cognitive functions may be tested, including attention, executive functioning, gnosia, language, memory, orientation, praxis, prosody, thought content, thought processes, and visuospatial proficiency. Proprietary and open-source clinical examination tools are available, such as the Mini-Mental State Examination and the Mini-Cog...
October 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/27925088/interdisciplinary-care-praxis-in-groups-of-people-living-with-fibromyalgia
#17
Nathália Aparecida Costa Guedes Miranda, Lina Márcia Miguéis Berardinelli, Vera Maria Sabóia, Irma da Silva Brito, Rosângela da Silva Santos
Objectives: to analyze the integrated community therapy model for the empowerment of people living with fibromyalgia and discuss the impact of this interdisciplinary intervention in the health-disease process and self-care. Method: a participatory-approach qualitative study, developed in 2015 with 11 participants at the Laboratory of Physiology Applied to Physical Education of the Rio de Janeiro State University, RJ. Data production comprised World Café, participant observation and semi-structured interview...
November 2016: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/27917642/can-nanotechnology-improve-cancer-diagnosis-through-mirna-detection
#18
Roberto Fiammengo
miRNAs are key regulators of gene expression, and alterations in their expression levels correlate with the onset and progression of cancer. Although miRNAs have been proposed as biomarkers for cancer diagnosis, their application in routine clinical praxis is yet to come. Current quantification strategies have limitation, and there is a great interest in developing innovative ones. Since a few years, nanotechnology-based approaches for miRNA quantification are emerging at fast pace but there is urgent need to go beyond the proof-of-concept stage...
January 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/27909252/nurses-as-antibiotic-brokers-institutionalized-praxis-in-the-hospital
#19
Alex Broom, Jennifer Broom, Emma Kirby, Graham Scambler
We are likely moving rapidly toward a post-antibiotic era, as a result of escalating antimicrobial resistance, rapidly declining antibiotic production and profligate overuse. Hitherto research has almost exclusively focused on doctors' prescribing, with nurses' roles in antibiotic use remaining virtually invisible. Drawing on interviews with 30 nurses, we focus on nurses as brokers of doctors' antibiotic decisions, nursing capacity to challenge doctors' decisions, and, "back stage" strategies for circumnavigating organizational constraints...
November 30, 2016: Qualitative Health Research
https://www.readbyqxmd.com/read/27895578/cognitive-performance-patterns-in-healthy-individuals-with-substantia-nigra-hyperechogenicity-and-early-parkinson-s-disease
#20
Rezzak Yilmaz, Susanne Gräber, Benjamin Roeben, Ulrike Suenkel, Anna-Katharina von Thaler, Sebastian Heinzel, Florian G Metzger, Gerhard W Eschweiler, Walter Maetzler, Daniela Berg, Inga Liepelt-Scarfone
Introduction: Hyperechogenicity of the substantia nigra (SN+) is a risk marker for Parkinson's disease (PD) which can be detected before the diagnosis. In healthy individuals, SN+ has been associated with slight deficits in specific cognitive functions, suggesting cognitive impairment as a possible pre-diagnostic marker for PD. However, the pattern of cognitive deficits associated with SN+ has not yet been compared with those present in PD. Methods: Data of 262 healthy individuals with normal echogenicity (SN-) and 48 healthy individuals with SN+ were compared with 82 early stage PD patients using the "Consortium to Establish a Registry for Alzheimer's disease" test battery...
2016: Frontiers in Aging Neuroscience
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