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https://www.readbyqxmd.com/read/29932213/rationales-for-expanding-minority-physician-representation-in-the-workforce-a-scoping-review
#1
Karen Kelly-Blake, Nanibaa' A Garrison, Faith E Fletcher, Brittany Ajegba, Nichole Smith, Morgann Brafford, Elizabeth Bogdan-Lovis
OBJECTIVES: The purpose of this study was to conduct a scoping review of the literature and to categorically map a 15-year trajectory of US undergraduate medical education rationales for and approaches to expanding under-represented minority (URM) physician representation in the medical workforce. Further aims were to comparatively examine related justifications and to consider international implications. METHODS: From 1 June to 31 July 2015, the authors searched the Cochrane Library, ERIC, PsycINFO, PubMed, Scopus, Web of Science and Google Scholar for articles published between 2000 and 2015 reporting rationales for and approaches to increasing the numbers of members of URMs in undergraduate medical school...
June 22, 2018: Medical Education
https://www.readbyqxmd.com/read/29927054/barriers-and-enablers-to-patient-recruitment-for-randomised-controlled-trials-on-treatment-of-chronic-wounds-a-systematic-review
#2
Lyndal Bugeja, Jac Kee Low, Rosemary A McGinnes, Victoria Team, Sankar Sinha, Carolina Weller
Randomised controlled trials represent the gold standard in intervention efficacy evaluation. However, suboptimal recruitment affects completion and the power of a therapeutic trial in detecting treatment differences. We conducted a systematic review to examine the barriers and enablers to patient recruitment for randomised controlled trials on chronic wound treatment. Review registration was under PROSPERO 2017:CRD42017062438. We conducted a systematic search of Ovid MEDLINE, EBSCOhost CINAHL, Ovid Cochrane Library, Ovid EMBASE, and Ovid PsycINFO databases in June 2017 for chronic wound treatment randomised controlled trials...
June 21, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29924306/clinical-relevance-of-genetic-variants-of-gonadotrophins-and-their-receptors-in-controlled-ovarian-stimulation-a-systematic-review-and-meta-analysis
#3
Carlo Alviggi, Alessandro Conforti, Daniele Santi, Sandro C Esteves, Claus Yding Andersen, Peter Humaidan, Paolo Chiodini, Giuseppe De Placido, Manuela Simoni
BACKGROUND: Genotype has been implicated in the outcome of ovarian stimulation. The analysis of patient-specific genotypes might lead to an individualized pharmacogenomic approach to controlled ovarian stimulation (COS). However, the validity of such an approach remains to be established. OBJECTIVE AND RATIONALE: To define the impact of specific genotype profiles of follicle-stimulating hormone, luteinizing hormone and their receptors (FSHR, LHR and LHCGR) on ovarian stimulation outcome...
June 18, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29921675/comparison-of-the-efficacy-and-acceptability-of-chinese-herbal-medicine-in-adult-patients-with-heart-failure-and-reduced-ejection-fraction-study-protocol-for-a-systematic-review-and-network-meta-analysis
#4
Jing Liu, Jin-Jin Lu, Kun Zhou, Jie Wan, Yan Li, Xiao-Yun Cui, Qun Gao, Yan-Chao Huang, Si-Nai Li, Qiao-Zhi Dong, Qian Lin
INTRODUCTION: Heart failure with reduced ejection fraction (HFrEF) is defined as the clinical diagnosis of heart failure (HF) and ejection fraction (EF) ≤40%, which is a severe public healthcare issue and brings a heavy social and economic burden for patients with HFrEF. Chinese herbal medicine (CHM) has a long history in treating HF. Questions concerning the efficacy and acceptability of CHM-related interventions in adult patients with HFrEF led us to use the method of systematic review and network meta-analysis to integrate direct and indirect evidence to create hierarchies for all CHM...
June 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29921438/no-238-supracervical-hysterectomy
#5
Sari Kives, Guylaine Lefebvre
OBJECTIVE: This guideline reviews the evidence relating to the potential benefits of the vaginal hysterectomy (VH) and supracervical hysterectomy (SCH) versus total abdominal hysterectomy (TAH) with respect to postoperative sexual function, urinary function, and peri- and postoperative complications. Laparoscopic options are not included in this guideline. OPTIONS: Women considering hysterectomy for benign disease can be given the option of retaining the cervix or proceeding with a total hysterectomy...
July 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29917160/the-relationship-between-healthcare-workers-attachment-styles-and-patient-outcomes-a-systematic-review
#6
Chizu Mimura, Ian J Norman
Purpose: To examine whether attachment styles of healthcare workers influence the quality of their relationships with patients, or impact patients' health outcomes. Data source: Literature database searches on the CINAHL, Cochrane Library, Embase, MEDLINE and PsyCinfo, and hand searching of reference lists of the retained articles. Study selection: Original empirical studies reporting an analysis of the relationship of interest were selected for review...
June 1, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29917015/sustainable-data-and-metadata-management-at-the-bd2k-lincs-data-coordination-and-integration-center
#7
Vasileios Stathias, Amar Koleti, Dušica Vidović, Daniel J Cooper, Kathleen M Jagodnik, Raymond Terryn, Michele Forlin, Caty Chung, Denis Torre, Nagi Ayad, Mario Medvedovic, Avi Ma'ayan, Ajay Pillai, Stephan C Schürer
The NIH-funded LINCS Consortium is creating an extensive reference library of cell-based perturbation response signatures and sophisticated informatics tools incorporating a large number of perturbagens, model systems, and assays. To date, more than 350 datasets have been generated including transcriptomics, proteomics, epigenomics, cell phenotype and competitive binding profiling assays. The large volume and variety of data necessitate rigorous data standards and effective data management including modular data processing pipelines and end-user interfaces to facilitate accurate and reliable data exchange, curation, validation, standardization, aggregation, integration, and end user access...
June 19, 2018: Scientific Data
https://www.readbyqxmd.com/read/29914382/a-systematic-review-of-non-pharmacological-interventions-to-improve-nighttime-sleep-among-residents-of-long-term-care-settings
#8
Elizabeth Capezuti, Rana Sagha Zadeh, Kevin Pain, Aleksa Basara, Nancy Ziyan Jiang, Ana C Krieger
BACKGROUND: Disturbances in sleep and circadian rhythms are common among residents of long-term care facilities. In this systematic review, we aim to identify and evaluate the literature documenting the outcomes associated with non-pharmacological interventions to improve nighttime sleep among long-term care residents. METHODS: The Preferred Reporting Items for Systematic Reviews guided searches of five databases (MEDLINE, Embase, CINAHL, Scopus, and Cochrane Library) for articles reporting results of experimental or quasi-experimental studies conducted in long-term care settings (nursing homes, assisted-living facilities, or group homes) in which nighttime sleep was subjectively or objectively measured as a primary outcome...
June 18, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29911519/the-effects-of-the-interventions-on-the-dnr-designation-among-cancer-patients-a-systematic-review
#9
Li-Ting Chen, Fei-Hsiu Hsiao
OBJECTIVE: The aims of this systematic review were to examine the effects of the overall and the different types of the interventions on the do-not-resuscitate (DNR) designation and the time between DNR and death among cancer patients. METHOD: Data were searched from the databases of PubMed, CINAHL, EMbase, Medline, and Cochrane Library through 2 November 2017. Studies were eligible for inclusion if they were (1) randomized control trails, quasi-experimental study, and retrospective observational studies and (2) used outcome indicators of DNR designation rates...
June 18, 2018: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29911110/optimization-of-a-microfluidics-based-next-generation-sequencing-assay-for-clinical-oncology-diagnostics
#10
Christine Henzler, Matthew Schomaker, Rendong Yang, Aaron P Lambert, Rebecca LaRue, Robyn Kincaid, Kenneth Beckman, Teresa Kemmer, Jon Wilson, Sophia Yohe, Bharat Thyagarajan, Andrew C Nelson
Background: Massively parallel, or next-generation, sequencing is a powerful technique for the assessment of somatic genomic alterations in cancer samples. Numerous gene targets can be interrogated simultaneously with a high degree of sensitivity. The clinical standard of care for many advanced solid and hematologic malignancies currently requires mutation analysis of several genes in the front-line setting, making focused next generation sequencing (NGS) assays an effective tool for clinical molecular diagnostic laboratories...
May 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29910086/respiratory-physiotherapy-in-intensive-care-unit-bibliographic-review
#11
R Goñi-Viguria, E Yoldi-Arzoz, L Casajús-Sola, T Aquerreta-Larraya, P Fernández-Sangil, E Guzmán-Unamuno, B M Moyano-Berardo
INTRODUCTION AND AIMS: Patients in intensive care unit are susceptible to complications due to different causes (underlying disease, immobilisation, infection risk…) The current main intervention in order to prevent these complications is respiratory physiotherapy, a common practice for nurses on a daily basis. Therefore, we decided to carry out this bibliographic review to describe the most efficient respiratory physiotherapy methods for the prevention and treatment of lung complications in patients in intensive care, taking into account the differences between intubated and non-intubated patients...
June 14, 2018: Enfermería Intensiva
https://www.readbyqxmd.com/read/29909797/a-review-of-integrated-heart-failure-care
#12
Julie MacInnes, Liz Williams
AimThe aim of this integrative review is to determine the effectiveness of integrated heart failure (HF) care in terms of patient-, service- and resource-related outcomes, and to determine what model or characteristics of integrated care work best, for whom and in what contexts. BACKGROUND: Integration of health and social care services is a significant driver in the development of better and more cost-effective health and social care systems in Europe and developed countries. As high users of health and social care services, considerable attention has been paid to the care of people with long-term conditions...
June 18, 2018: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29909732/cognitive-outcomes-after-cochlear-implantation-in-older-adults-a-systematic-review
#13
Annes J Claes, Paul Van de Heyning, Annick Gilles, Vincent Van Rompaey, Griet Mertens
OBJECTIVES: To critically assess the current status of the literature on cognitive outcomes after cochlear implantation in older adults. METHODS: Studies were identified by searching MEDLINE (PubMed) and Cochrane Library, and checking reference lists of relevant articles. No restrictions were imposed regarding language, publication date, or publication status. Eligibility criteria were as follows: (1) the study sample included older adults aged 50 or over with severe to profound bilateral hearing loss, (2) the participants received a multi-electrode cochlear implant, and (3) a cognitive test was performed before and after implantation...
June 18, 2018: Cochlear Implants International
https://www.readbyqxmd.com/read/29905465/pyrophosphate-induced-intramolecular-excimer-formation-in-dinuclear-zinc-ii-complexes-with-tetrakisquinoline-ligands
#14
Yuji Mikata, Risa Ohnishi, Risa Nishijima, Arimasa Matsumoto, Hideo Konno
Dinuclear Zn2+ complexes with HTQHPN ( N,N,N' ,N'-tetrakis(2-quinolylmethyl)-2-hydroxy-1,3-propanediamine) derivatives have been prepared, and their pyrophosphate (PPi, P2 O7 4- ) sensing properties were examined. The ligand library includes six HTQHPN derivatives with electron-donating/withdrawing substituents, an extended aromatic ring, and six-membered chelates upon zinc binding. Complexation of ligand with 2 equiv of Zn2+ promotes small to moderate fluorescence enhancement around 380 nm, but in the cases of HTQHPN, HT(6-FQ)HPN ( N,N,N' ,N'-tetrakis(6-fluoro-2-quinolylmethyl)-2-hydroxy-1,3-propanediamine), and HT(8Q)HPN ( N,N,N' ,N'-tetrakis(8-quinolylmethyl)-2-hydroxy-1,3-propanediamine), subsequent addition of PPi induced a significant fluorescence increase around 450 nm...
June 15, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29904990/the-communal-consultation-video-enhancing-learning-and-broadening-experience-through-observing-dialogue
#15
M G Botelho
INTRODUCTION: This study presents a novel, student-centred, on-demand video learning modality that supports students as they transition from theory to clinical practice. Authentic, one-to-one teacher and student consultations have been video recorded and uploaded online for the peers and subsequent years of students to consume and learn from. This study describes the development and use of these communal consultation videos (CCVs), examines how students perceive this novel intervention and proposes supporting educational theory...
June 14, 2018: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/29904897/anterior-cruciate-ligament-repair-past-present-and-future
#16
REVIEW
Piyush Mahapatra, Saman Horriat, Bobby S Anand
BACKGROUND: This article provides a detailed narrative review on the history and current concepts surrounding ligamentous repair techniques in athletic patients. In particular, we will focus on the anterior cruciate ligament (ACL) as a case study in ligament injury and ligamentous repair techniques. PubMed (MEDLINE), EMBASE and Cochrane Library databases for papers relating to primary anterior cruciate ligament reconstruction were searched by all participating authors. All relevant historical papers were included for analysis...
June 15, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29899590/anti-scatter-grid-artifact-elimination-for-high-resolution-x-ray-imaging-detectors-without-a-prior-scatter-distribution-profile
#17
S V Setlur Nagesh, R Rana, D R Bednarek, S Rudin
Using anti-scatter grids with high-resolution imaging detectors could result in grid-line artifacts, with increasing severity as detector resolution improves. Grid-line mask subtraction can result in residual artifacts that are due to residual scatter penetrating the grid and not subtracted. By subtracting this residual scatter, the grid artifacts can be minimized. In the previous works, an initial residual-scatter estimate was derived by placing lead markers on a test object; however, any change in the object geometry requires a new scatter estimate...
February 2018: Proceedings of SPIE
https://www.readbyqxmd.com/read/29897915/the-role-of-social-determinants-of-health-in-the-risk-and-prevention-of-group-a-streptococcal-infection-acute-rheumatic-fever-and-rheumatic-heart-disease-a-systematic-review
#18
Pasqualina M Coffey, Anna P Ralph, Vicki L Krause
BACKGROUND: Rheumatic heart disease (RHD) poses a major disease burden among disadvantaged populations globally. It results from acute rheumatic fever (ARF), a complication of Group A Streptococcal (GAS) infection. These conditions are acknowledged as diseases of poverty, however the role of specific social and environmental factors in GAS infection and progression to ARF/RHD is not well understood. The aim of this systematic review was to determine the association between social determinants of health and GAS infection, ARF and RHD, and the effect of interventions targeting these...
June 13, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29893936/multi-behavioral-endpoint-testing-of-an-87-chemical-compound-library-in-freshwater-planarians
#19
Siqi Zhang, Danielle Hagstrom, Patrick Hayes, Aaron Graham, Eva-Maria S Collins
There is an increased recognition in the field of toxicology of the value of medium-to-high-throughput screening methods using in vitro and alternative animal models. We have previously introduced the asexual freshwater planarian Dugesia japonica as a new alternative animal model and proposed that it is particularly well-suited for the study of developmental neurotoxicology. In this paper, we discuss how we have expanded and automated our screening methodology to allow for fast screening of multiple behavioral endpoints, developmental toxicity, and mortality...
June 8, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29886882/the-use-of-a-perioperative-supra-physiological-dose-of-glucocorticoid-is-not-supported-by-evidence-a-systematic-review
#20
Bashir Fouad Khazen, Alaa El-Hussuna
INTRODUCTION: A supra-physiological dose of glucocorticoid (SDS) is administered routinely in the perioperative management of patients on long-term regular glucocorticoid therapy. The dose of glucocorticoid used in these regimens varies. The current treatment is based on two 60-year-old case reports. No data exist to document the required dose of glucocorticoid to prevent perioperative hypotension or the category of patients needing this dose. Having in mind that high doses of glucocorticoids have several potential side effects, this practice ought to be re-evaluated in the light of available evidence...
June 2018: Danish Medical Journal
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