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https://www.readbyqxmd.com/read/28088382/functional-electrical-stimulation-for-foot-drop-in-multiple-sclerosis-a-systematic-review-and-meta-analysis-of-the-impact-on-gait-speed
#1
REVIEW
Linda Miller, Angus McFadyen, Anna C Lord, Rebecca Hunter, Lorna Paul, Danny Rafferty, Roy Bowers, Paul Mattison
OBJECTIVE: To review the efficacy of functional electrical stimulation (FES) used for foot drop in people with multiple sclerosis (pwMS) on gait speed in short and long walking performance tests. DATA SOURCES: Five databases (Cochrane Library, CINAHL, Embase, MEDLINE, Pubmed) and reference lists were searched. STUDY SELECTION: Studies of both observational and experimental design where gait speed data in pwMS could be extracted were included...
January 11, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28086971/characteristics-and-use-of-urban-health-indicator-tools-by-municipal-built-environment-policy-and-decision-makers-a-systematic-review-protocol
#2
Helen Pineo, Ketevan Glonti, Harry Rutter, Nicole Zimmermann, Paul Wilkinson, Michael Davies
BACKGROUND: There is wide agreement that there is a lack of attention to health in municipal environmental policy-making, such as urban planning and regeneration. Explanations for this include differing professional norms between health and urban environment professionals, system complexity and limited evidence for causality between attributes of the built environment and health outcomes. Data from urban health indicator (UHI) tools are potentially a valuable form of evidence for local government policy and decision-makers...
January 13, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28074328/lipidpioneer-a-comprehensive-user-generated-exact-mass-template-for-lipidomics
#3
Candice Z Ulmer, Jeremy P Koelmel, Jared M Ragland, Timothy J Garrett, John A Bowden
Lipidomics, the comprehensive measurement of lipid species in a biological system, has promising potential in biomarker discovery and disease etiology elucidation. Advances in chromatographic separation, mass spectrometric techniques, and novel substrate applications continue to expand the number of lipid species observed. The total number and type of lipid species detected in a given sample are generally indicative of the sample matrix examined (e.g., serum, plasma, cells, bacteria, tissue, etc.). Current exact mass lipid libraries are static and represent the most commonly analyzed matrices...
January 10, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28073996/estimate-of-false-positive-breast-cancer-diagnoses-from-accuracy-studies-a-systematic-review
#4
REVIEW
Nereo Segnan, Silvia Minozzi, Antonio Ponti, Cristina Bellisario, Sara Balduzzi, Marien González-Lorenzo, Silvia Gianola, Paola Armaroli
BACKGROUND: False-positive histological diagnoses have the same consequences of overdiagnosis in terms of unnecessary treatment. The aim of this systematic review is to assess their frequency at needle core biopsy (CB) and/or surgical excision of the breast. METHODS: PubMed, Embase, Cochrane Library were systematically searched up to 30 October 2015. Eligibility criteria: cross-sectional studies assessing diagnostic accuracy of CB compared with surgical excision; studies assessing reproducibility of pathologists reading the same slides...
January 10, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28069174/management-and-counseling-of-the-male-with-advanced-paternal-age
#5
REVIEW
Michael O Jennings, Ryan C Owen, David Keefe, Edward D Kim
Increasing percentages of children are being born to older fathers. This has resulted in concerns about the potential adverse effects of advanced paternal age. To help clinicians counsel couples, a systemic review was performed to attempt to address questions that these couples may ask: Should routine sperm testing be performed in older males? Should preimplantation genetic diagnosis (PGD) be performed? How do providers counsel patients about risk? Should young males freeze sperm if they plan to delay paternity? Using the terms "advanced paternal age", "semen testing", "preimplantation genetic diagnosis/screening", and "cryopreservation", a comprehensive search was performed in PubMed and the Cochrane Library, and numerous international societal guidelines were reviewed...
January 6, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28066818/microbiome-helper-a-custom-and-streamlined-workflow-for-microbiome-research
#6
André M Comeau, Gavin M Douglas, Morgan G I Langille
Sequence-based approaches to study microbiomes, such as 16S rRNA gene sequencing and metagenomics, are uncovering associations between microbial taxa and a myriad of factors. A drawback of these approaches is that the necessary sequencing library preparation and bioinformatic analyses are complicated and continuously changing, which can be a barrier for researchers new to the field. We present three essential components to conducting a microbiome experiment from start to finish: first, a simplified and step-by-step custom gene sequencing protocol that requires limited lab equipment, is cost-effective, and has been thoroughly tested and utilized on various sample types; second, a series of scripts to integrate various commonly used bioinformatic tools that is available as a standalone installation or as a single downloadable virtual image; and third, a set of bioinformatic workflows and tutorials to provide step-by-step guidance and education for those new to the microbiome field...
January 2017: MSystems
https://www.readbyqxmd.com/read/28063544/the-prevention-of-early-onset-neonatal-group-b-streptococcal-disease
#7
Deborah Money, Victoria M Allen
OBJECTIVE: To review the evidence in the literature and to provide recommendations on the management of pregnant women in labour for the prevention of early-onset neonatal group B streptococcal disease. The key revisions in this updated guideline include changed recommendations for regimens for antibiotic prophylaxis, susceptibility testing, and management of women with pre-labour rupture of membranes. OUTCOMES: Maternal outcomes evaluated included exposure to antibiotics in pregnancy and labour and complications related to antibiotic use...
December 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28063462/going-digital-a-narrative-overview-of-the-clinical-and-organisational-impacts-of-ehealth-technologies-in-hospital-practice
#8
Justin Keasberry, Ian A Scott, Clair Sullivan, Andrew Staib, Richard Ashby
Objective The aim of the present study was to determine the effects of hospital-based eHealth technologies on quality, safety and efficiency of care and clinical outcomes.Methods Systematic reviews and reviews of systematic reviews of eHealth technologies published in PubMed/Medline/Cochrane Library between January 2010 and October 2015 were evaluated. Reviews of implementation issues, non-hospital settings or remote care or patient-focused technologies were excluded from analysis. Methodological quality was assessed using a validated appraisal tool...
January 9, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28063084/methodological-issues-surrounding-the-use-of-baseline-health-related-quality-of-life-data-to-inform-trial-based-economic-evaluations-of-interventions-within-emergency-and-critical-care-settings-a-systematic-literature-review
#9
REVIEW
Melina Dritsaki, Felix Achana, James Mason, Stavros Petrou
BACKGROUND: Trial-based cost-utility analyses require health-related quality of life data that generate utility values in order to express health outcomes in terms of quality-adjusted life years (QALYs). Assessments of baseline health-related quality of life are problematic where trial participants are incapacitated or critically ill at the time of randomisation. This review aims to identify and critique methods for handling non-availability of baseline health-related quality of life data in trial-based cost-utility analyses within emergency and critical illness settings...
January 6, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28062410/distance-learning-for-updating-health-professionals-in-palliative-care-a-systematic-review
#10
Anderson Luiz Carvalho Taroco, Tania Cristina de Oliveira Valente, Camila Soares Carbogim
OBJECTIVES: To review literature regarding online educational initiatives in palliative care which are targeted to update health professionals and prepare distance courses suitable for a Brazilian context. METHODS: 7 databases (PubMed, Cochrane Library, LILACS, SCIELO, CINAHL, Science Direct and Scopus) were reviewed for published papers between January 2004 and August 2014 using the PRISMA methodology. Included studies focused on health professionals and had at least part of the course in a distance learning approach...
January 6, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28059834/what-do-we-know-about-intraoperative-teaching-a-systematic-review
#11
Matthew D Timberlake, Helen G Mayo, Lauren Scott, Joshua Weis, Aimee K Gardner
BACKGROUND: There is increasing attention on enhancing surgical trainee performance and competency. The purpose of this review is to identify characteristics and themes related to intraoperative teaching that will better inform interventions and assessment endeavors. METHODS: A systematic search was carried out of the Ovid MEDLINE, Ovid MEDLINE InProcess, Ovid Embase, and the Cochrane Library databases to identify all studies that discussed teaching in the operating room for trainees at the resident and fellow level...
January 3, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28059130/rapidly-discriminate-commercial-medicinal-pulsatilla-chinensis-bge-regel-from-its-adulterants-using-its2-barcoding-and-specific-pcr-rflp-assay
#12
Yuhua Shi, Mingming Zhao, Hui Yao, Pei Yang, Tianyi Xin, Bin Li, Wei Sun, Shilin Chen
Pulsatillae radix is a conventional traditional Chinese medicine (TCM) with common name Baitouweng, and has notable effects on inflammation and dysentery. Pulsatilla chinensis (Bge.) Regel is the only source plant of Baitouweng recorded in Chinese Pharmacopoeia, but its adulteration often occurs in the market that possibly affects medicinal efficacy and safety. We have established an internal transcribed spacer 2 (ITS2) barcode library based on 105 plant samples from 12 Pulsatilla species and 10 common adulterants...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28057608/acupuncture-for-children-with-cerebral-palsy-a-systematic-review-protocol
#13
Taipin Guo, Bowen Zhu, Qian Zhang, Yejiao Yang, Qi He, Xinghe Zhang, Xiantao Tai
BACKGROUND: Cerebral palsy (CP), a childhood disease of high morbidity and serious harmfulness, has no effective therapies to completely relieve the associated pain. Acupuncture has been used widely in China to alleviate several CP symptoms, such as pain and motion disorders, despite the deficiency of high-quality evidence related to this practice. OBJECTIVE: The aim of this systematic review protocol is to assess the efficacy and safety of acupuncture for the treatment of children with CP...
January 5, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28057024/behavior-change-interventions-and-policies-influencing-primary-healthcare-professionals-practice-an-overview-of-reviews
#14
REVIEW
Bhupendrasinh F Chauhan, Maya Jeyaraman, Amrinder Singh Mann, Justin Lys, Becky Skidmore, Kathryn M Sibley, Ahmed Abou-Setta, Ryan Zarychanksi
BACKGROUND: There is a plethora of interventions and policies aimed at changing practice habits of primary healthcare professionals, but it is unclear which are the most appropriate, sustainable, and effective. We aimed to evaluate the evidence on behavior change interventions and policies directed at healthcare professionals working in primary healthcare centers. METHODS: Study design: overview of reviews. DATA SOURCE: MEDLINE (Ovid), Embase (Ovid), The Cochrane Library (Wiley), CINAHL (EbscoHost), and grey literature (January 2005 to July 2015)...
January 5, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28050138/adjuvant-systemic-chemotherapy-for-stages-ii-and-iii-colon-cancer-after-complete-resection-a-clinical-practice-guideline
#15
B M Meyers, R Cosby, F Quereshy, D Jonker
BACKGROUND: Updated practice guidelines on adjuvant chemotherapy for completely resected colon cancer are lacking. In 2008, Cancer Care Ontario's Program in Evidence-Based Care developed a guideline on adjuvant therapy for stages ii and iii colon cancer. With newer regimens being assessed in this patient population and older agents being either abandoned because of non-effectiveness or replaced by agents that are more efficacious, a full update of the original guideline was undertaken...
December 2016: Current Oncology
https://www.readbyqxmd.com/read/28048663/tu-fg-207a-05-winners-1-2-3-and-q-a
#16
C McCollough
: Peer-reviewed journals and conference proceedings publish hundreds of papers that describe new medical imaging algorithms, including, for example, techniques for computer-aided diagnosis or characterization, segmentation, image registration, image reconstruction, and radiomics. It is difficult, if not impossible, to fairly compare the performance of these algorithms as investigators must either use different data sets, or if using the same data, use different implementations of competing algorithms...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048651/tu-fg-207a-03-overview-of-ct-reconstruction-and-denoising-strategies
#17
N Pelc
: Peer-reviewed journals and conference proceedings publish hundreds of papers that describe new medical imaging algorithms, including, for example, techniques for computer-aided diagnosis or characterization, segmentation, image registration, image reconstruction, and radiomics. It is difficult, if not impossible, to fairly compare the performance of these algorithms as investigators must either use different data sets, or if using the same data, use different implementations of competing algorithms...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048540/we-de-201-04-cross-validation-of-knowledge-based-treatment-planning-for-prostate-ldr-brachytherapy-using-principle-component-analysis
#18
J Roper, B Ghavidel, V Chanyavanich, K Godette, E Schreibmann
PURPOSE: To validate a knowledge-based algorithm for prostate LDR brachytherapy treatment planning. METHODS: A dataset of 100 cases was compiled from an active prostate seed implant service. Cases were randomized into 10 subsets. For each subset, the 90 remaining library cases were registered to a common reference frame and then characterized on a point by point basis using principle component analysis (PCA). Each test case was converted to PCA vectors using the same process and compared with each library case using a Mahalanobis distance to evaluate similarity...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047984/tu-fg-207a-04-overview-of-the-low-dose-ct-grand-challenge
#19
C McCollough
: Peer-reviewed journals and conference proceedings publish hundreds of papers that describe new medical imaging algorithms, including, for example, techniques for computer-aided diagnosis or characterization, segmentation, image registration, image reconstruction, and radiomics. It is difficult, if not impossible, to fairly compare the performance of these algorithms as investigators must either use different data sets, or if using the same data, use different implementations of competing algorithms...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047377/mo-fg-202-02-automated-plan-quality-assurance-integrated-with-eclipse-using-varian-s-esapi-interface
#20
E Schreibmann, I Crocker, A Dhabaan, E Elder
PURPOSE: Treatment plan compliance to physician's intent is still assessed by hand in clinical practice by visually comparing prescription details against corresponding plan values. We report on a script that uses the Varian's programming interface to automate the scoring of treatment plan dose values to the physician's prescribed constraints. METHODS: The Eclipse Scripting Advance Programming Interface (ESAPI) is a FDA-approved scripting environment written in C# that allows programming access to a patient's record in Aria and Eclipse...
June 2016: Medical Physics
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