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https://www.readbyqxmd.com/read/28819682/laparoscopy-or-laparotomy-as-the-way-of-entrance-in-myoma-enucleation
#1
REVIEW
Cristina Cezar, Sven Becker, Attilio di Spiezio Sardo, Anja Herrmann, Angelika Larbig, Vasilis Tanos, Luz Angela Torres de la Roche, Hugo Christian Verhoeven, Markus Wallwiener, Rudy Leon De Wilde
PURPOSE: Uterine myomas are the main cause of benign uterine diseases in premenopausal women. Objective of the present paper is to investigate the current best treatment modalities of myomas, depending on age of the patient and her desire to preserve fertility, as well as on clinical presentation of this pathology, such as size, number, and location of fibroids and, furthermore, on surgical experience of the gynecologist. METHODS: The design of our work is a systematic literature review of existing studies, reviews, and meta-analysis conducted in PubMed and Cochrane Library to identify relevant literature...
August 17, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28812122/-how-does-knowledge-reach-health-care-practice-implementation-research-and-knowledge-circulation
#2
REVIEW
Horst Christian Vollmar, Sara Santos, Anneke de Jong, Gabriele Meyer, Stefan Wilm
BACKGROUND: Evidence-based knowledge is among the most important resources in health care. However, relevant knowledge is often not implemented. There are about 100 different concepts for the "knowledge-to-practice gap". OBJECTIVES: We conducted this review to identify relevant concepts that describe and try to overcome this situation: implementation research and knowledge translation or circulation. MATERIALS AND METHODS: We initially conducted a systematic search in the databases CINAHL, Embase, ERIC, Medline, PsycINFO, Scopus, Cochrane Library and Web of Science without time or language restrictions...
August 15, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28810901/immediate-versus-delayed-surgery-for-hip-fractures-in-the-elderly-patients-a-protocol-for-a-systematic-review-and-meta-analysis
#3
Thomas Klestil, Christoph Röder, Christoph Stotter, Birgit Winkler, Stefan Nehrer, Martin Lutz, Irma Klerings, Gernot Wagner, Gerald Gartlehner, Barbara Nussbaumer-Streit
BACKGROUND: Hip fractures are a major public health problem in elderly populations and are accompanied by high-mortality rates. Whether timing of surgery has an impact on morbidity and mortality has been discussed controversially, numerous studies suggest that the delay of surgery can significantly increase the risk of morbidity and mortality; others report that achieving a stable medical condition is more important than early surgery. The goal of our systematic review is to assess the impact of timing of surgery on health outcomes in patients aged 60 years or older with acute hip fracture...
August 15, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28809009/docking-and-virtual-screening-in-drug-discovery
#4
Maria Kontoyianni
Stages in a typical drug discovery organization include target selection, hit identification, lead optimization, preclinical and clinical studies. Hit identification and lead optimization are very much intertwined with computational modeling. Structure-based virtual screening (VS) has been a staple for more than a decade now in drug discovery with its underlying computational technique, docking, extensively studied. Depending on the objective, the parameters for VS may change, but the overall protocol is very straightforward...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28807047/adverse-outcomes-associated-with-opioid-prescription-for-acute-low-back-pain-a-systematic-review-protocol
#5
Natalia Mouravska, Laura Zielinski, Meha Bhatt, Nitika Sanger, Monica Bawor, Brittany Dennis, Laura Banfield, James MacKillop, James Paul, Andrew Worster, Philip Laplante, Lehana Thabane, Zainab Samaan
BACKGROUND: Acute low back pain (ALBP) is the top cause of global disability, demonstrating a significant impact on individuals and society and demanding the need for appropriate management. There is a trend towards an increasing number of opioid prescriptions for ALBP despite the lack of investigation for its various short- and long-term outcomes. The objective of this review is to examine adverse outcomes associated with opioid use for ALBP. METHODS/DESIGN: Using a search strategy, the search will be conducted using the following electronic databases: PubMed/MEDLINE, EMBASE, PsycINFO, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science, Cochrane Library, the National Institutes for Health Clinical Trials Registry and the World Health Organization International Clinical Trials Registry Platform (WHO ICTRP)...
August 14, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28803752/optimal-dose-timing-and-ratio-of-blood-products-in-massive-transfusion-results-from-a-systematic-review
#6
REVIEW
Zoe K McQuilten, Gemma Crighton, Susan Brunskill, Jessica K Morison, Tania H Richter, Neil Waters, Michael F Murphy, Erica M Wood
Optimal dose, timing and ratio to red blood cells (RBC) of blood component therapy (fresh frozen plasma [FFP], platelets, cryoprecipitate or fibrinogen concentrate) to reduce morbidity and mortality in critically bleeding patients requiring massive transfusion is unknown. We performed a systematic review for randomized controlled trials (RCT) in MEDLINE, The Cochrane Library, Embase, CINAHL, PubMed the Transfusion Evidence Library and using multiple clinical trials registries to 21 February 2017. Sixteen RCTs were identified: six completed (five in adult trauma patients, one pediatric burn patients) and ten ongoing trials...
July 6, 2017: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/28802519/espen-guidelines-on-nutritional-support-for-polymorbid-internal-medicine-patients
#7
Filomena Gomes, Philipp Schuetz, Lisa Bounoure, Peter Austin, María Ballesteros-Pomar, Tommy Cederholm, Jane Fletcher, Alessandro Laviano, Kristina Norman, Kalliopi-Anna Poulia, Paula Ravasco, Stephane M Schneider, Zeno Stanga, C Elizabeth Weekes, Stephan C Bischoff
BACKGROUND & AIMS: Polymorbidity (also known as multimorbidity) - defined as the co-occurrence of at least two chronic health conditions - is highly prevalent, particularly in the hospitalized population. Nonetheless, clinical guidelines largely address individual diseases and rarely account for polymorbidity. The aim of this project was to develop guidelines on nutritional support for polymorbid patients hospitalized in medical wards. METHODS: The methodology used for the development of the current project follows the standard operating procedures for ESPEN guidelines...
July 24, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28800056/effectiveness-of-structured-planned-post-discharge-support-to-patients-with-chronic-obstructive-pulmonary-disease-for-reducing-readmission-rates-a-systematic-review
#8
Preben Ulrich Pedersen, Karen Bagger Ersgard, Tina Brandt Soerensen, Palle Larsen
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease, characterized by airflow limitation. The disease has a significant impact on the lives of patients and is a challenge for the health care due to readmissions to hospitals. OBJECTIVES: This review aimed to identify, appraise and synthesize the best available evidence on the effectiveness of discharge interventions that can reduce readmission of patients with COPD. TYPES OF PARTICIPANTS: Hospitalized patients, aged 18 years or over, who had been diagnosed with COPD and were admitted to hospital due to acute exacerbation...
August 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28799510/safety-profile-of-the-newest-antiepileptic-drugs-a-curated-literature-review
#9
Caterina Palleria, Giuseppe Cozza, Rajeshree Khengar, Vincenzo Libri, Giovambattista De Sarro
BACKGROUND: Despite the introduction of new antiepileptic drugs (AEDs), the quality of life and therapeutic response for patients with epilepsy remain unsatisfactory. In addition, whilst several antiepileptic drugs (AEDs) have been approved and consequently marketed in recent years, little is known about their long-term safety and tolerability. Availability of the newest AEDs, characterized by improved pharmacokinetic profiles, has positively impacted the treatment approach for patients with partial seizures in clinical practice...
August 9, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28797806/towards-personalized-medicine-for-patients-with-autoimmune-diseases-opportunities-and-challenges
#10
REVIEW
Soheil Tavakolpour
There is generally no cure for autoimmune disorders, but the symptoms can be managed. Currently available drugs/treatments are more potent than those in the past decades. However, finding the right drug and right patients has remained a serious problem. We should revise our diagnosis criteria to more accurate ones. During the recent years, personalized medicine has attracted much attention. However, it needs to be well-explained for autoimmune diseases. Personalized medicine aims to find the most optimum drugs for a patient...
August 7, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28797573/digestive-decontamination-in-burn-patients-a-systematic-review-of-randomized-clinical-trials-and-observational-studies
#11
REVIEW
Mercedes Rubio-Regidor, Ana Martín-Pellicer, Luciano Silvestri, Hendrik K F van Saene, José A Lorente, Miguel A de la Cal
OBJECTIVE: The objective of this systematic review is to assess the effect of selective digestive decontamination (SDD) or non-absorbable enteral antibiotics (EA) on mortality, the incidence of infection and its adverse effects in burn patients. MATERIAL AND METHODS: Systematic review of randomized clinical trials (RCT) or observational studies enrolling burn patients, and comparing SDD or EA prophylaxis with placebo or no treatment. The search includes Pubmed/Medline, EMBASE, WOS, Cochrane Library (1970-2015)...
August 7, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28796500/molecular-structure-based-large-scale-prediction-of-chemical-induced-gene-expression-changes
#12
Ruifeng Liu, Mohamed Diwan M AbdulHameed, Anders Wallqvist
The quantitative structure-activity relationship (QSAR) approach has been used to model a wide range of chemical-induced biological responses. However, it had not been utilized to model chemical-induced genome-wide gene expression changes until very recently, owing to the complexity of training and evaluating a very large number of models. To address this issue, we examined the performance of a variable nearest neighbor (v-NN) method that uses information of near neighbors conforming to the principle that similar structures have similar activities...
August 10, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28794640/volumetric-modulated-arc-therapy-for-treatment-of-solid-tumors-current-insights
#13
REVIEW
Gabriella Macchia, Francesco Deodato, Savino Cilla, Silvia Cammelli, Alessandra Guido, Martina Ferioli, Giambattista Siepe, Vincenzo Valentini, Alessio Giuseppe Morganti, Gabriella Ferrandina
AIM: This article discusses the current use of volumetric modulated arc therapy (VMAT) techniques in clinical practice and reviews the available data from clinical outcome studies in different clinical settings. An overview of available literature about clinical outcomes with VMAT stereotactic/radiosurgical treatment is also reported. MATERIALS AND METHODS: All published manuscripts reporting the use of VMAT in a clinical setting from 2009 to November 2016 were identified...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28793120/functional-health-literacy-and-adherence-to-the-medication-in-older-adults-integrative-review
#14
Nidia Farias Fernandes Martins, Daiane Porto Gautério Abreu, Bárbara Tarouco da Silva, Deisa Salyse Dos Reis Cabral Semedo, Marlene Teda Pelzer, Fabiana Souza Ienczak
Objective: to characterize the national and international scientific production on the relationship of Functional Health Literacy and the adherence to the medication in older adults. Method: integrative review of literature, searching the following online databases: Scientific Electronic Library Online (SCIELO); Latin American and Caribbean Health Sciences Literature (LILACS); Medical Literature Analysis and Retrieval System Online (MEDLINE); and Cumulative Index to Nursing & Allied Health Literature (CINAHL), in June 2016...
July 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28792687/ols-client-and-ols-dialog-open-source-tools-to-annotate-public-omics-datasets
#15
Yasset Perez-Riverol, Tobias Ternent, Maximilian Koch, Harald Barsnes, Olga Vrousgou, Simon Jupp, Juan Antonio Vizcaíno
The availability of user-friendly software to annotate biological datasets and experimental details is becoming essential in data management practices, both in local storage systems and in public databases. The Ontology Lookup Service (OLS, http://www.ebi.ac.uk/ols) is a popular centralized service to query, browse and navigate biomedical ontologies and controlled vocabularies. Recently, the OLS framework has been completely redeveloped (version 3.0), including enhancements in the data model, like the added support for Web Ontology Language (OWL)-based ontologies, among many other improvements...
August 9, 2017: Proteomics
https://www.readbyqxmd.com/read/28790228/association-between-serum-uric-acid-and-non-alcoholic-fatty-liver-disease-a-meta-analysis
#16
Guntur Darmawan, Laniyati Hamijoyo, Irsan Hasan
BACKGROUND: non-alcoholic fatty liver disease (NAFLD) is known to be associated with some metabolic disorders. Recent studies suggested the role of uric acid in NAFLD through oxidative stress and inflammatory process. This study is aimed to evaluate the association between serum uric acid and NAFLD. METHODS: a systematic literature review was conducted using Pubmed and Cochrane library. The quality of all studies was assessed using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE)...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28775196/systematic-review-and-meta-analysis-of-infant-and-young-child-feeding-practices-enat-p-in-ethiopia-protocol
#17
Tesfa Dejenie Habtewold, Md Atiqul Islam, Nigussie Tadesse Sharew, Shimels Hussien Mohammed, Mulugeta Molla Birhanu, Balewgizie Sileshi Tegegne
INTRODUCTION: Infant and young child feeding (IYCF) is the cornerstone of infant and child survival, healthy growth and development, healthy future generations and national development. In spite of the importance of optimal nutrition in low- and middle-income countries, there has been no review conducted in Ethiopia. Thus, the aim of this systematic review and meta-analysis is to estimate the national coverage and identify the associated factors of IYCF practices in Ethiopia. METHODS: PubMed, Scopus, EMBASE, CINHAL, EBSCO, Web of Science and WHO Global Health Library databases will be searched for all available publications from 1 January 2000 to 30 September 2017...
August 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28774374/effectiveness-and-cost-effectiveness-of-serum-b-type-natriuretic-peptide-testing-and-monitoring-in-patients-with-heart-failure-in-primary-and-secondary-care-an-evidence-synthesis-cohort-study-and-cost-effectiveness-model
#18
Maria Pufulete, Rachel Maishman, Lucy Dabner, Syed Mohiuddin, William Hollingworth, Chris A Rogers, Julian Higgins, Mark Dayer, John Macleod, Sarah Purdy, Theresa McDonagh, Angus Nightingale, Rachael Williams, Barnaby C Reeves
BACKGROUND: Heart failure (HF) affects around 500,000 people in the UK. HF medications are frequently underprescribed and B-type natriuretic peptide (BNP)-guided therapy may help to optimise treatment. OBJECTIVE: To evaluate the clinical effectiveness and cost-effectiveness of BNP-guided therapy compared with symptom-guided therapy in HF patients. DESIGN: Systematic review, cohort study and cost-effectiveness model. SETTING: A literature review and usual care in the NHS...
August 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28770891/feedback-in-a-clinical-setting-a-way-forward-to-enhance-student-s-learning-through-constructive-feedback
#19
Amber Shamim Sultan, Muhammad Arif Mateen Khan
Feedback is considered as a dynamic process in which information about the observed performance is used to promote the desirable behaviour and correct the negative ones. The importance of feedback is widely acknowledged, but still there seems to be inconsistency in the amount, type and timing of feedback received from the clinical faculty. No significant effort has been put forward from the educator end to empower the learners with the skills of receiving and using the feedback effectively. Some institutions conduct faculty development workshops and courses to facilitate the clinicians on how best to deliver constructive feedback to the learners...
July 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28766955/risk-factors-of-stomal-recurrence-after-laryngectomy-a-systematic-review-and-meta-analysis
#20
Jinyu Mei, Zhaohui Huang, Kaile Wu, Yi Zhao, Jianming Yang, Yehai Liu
OBJECTIVE: We wished to investigate the risk factors for stoma recurrence following laryngectomy. METHODS: PubMed, Cochrane Library, and Embase were searched to identify primary research studies published between January 1, 1967, and October 31, 2016. We only included observational epidemiological studies and used risk ratios (RRs) and 95% confidence intervals (CI) to summarize the primary risk factors associated with recurrence following laryngectomy. RESULTS: A total of 44 articles, including 11 928 patients, were included in the current meta-analysis...
September 2017: Annals of Otology, Rhinology, and Laryngology
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