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https://www.readbyqxmd.com/read/29688032/setting-up-an-epathology-service-at-cleveland-clinic-abu-dhabi-joint-collaboration-with-cleveland-clinic-united-states
#1
Ayoub Nahal, Crystal Mildred O Batac, Renee J Slaw, Thomas W Bauer
CONTEXT: - The production of whole slide images is the most advanced form of digital pathology, in which a high-resolution digital scanner is used to rapidly scan glass microscope slides and produce a computer-generated whole slide image that can be saved, stored in a network-attached storage device, and accessed through slide management software within the hospital domain and remotely by authorized users. Digital transformation of glass slides has revolutionized the practice of anatomic pathology by facilitating and expediting consultative services, improving clinical workflow, and becoming an indispensable tool in education and research...
April 24, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29687454/interventions-for-implementation-of-thromboprophylaxis-in-hospitalized-patients-at-risk-for-venous-thromboembolism
#2
REVIEW
Susan R Kahn, David R Morrison, Gisèle Diendéré, Alexandre Piché, Kristian B Filion, Adi J Klil-Drori, James D Douketis, Jessica Emed, André Roussin, Vicky Tagalakis, Martin Morris, William Geerts
BACKGROUND: Venous thromboembolism (VTE) is a leading cause of morbidity and mortality in hospitalized patients. While numerous randomized controlled trials (RCTs) have shown that the appropriate use of thromboprophylaxis in hospitalized patients at risk for VTE is safe, effective, and cost-effective, thromboprophylaxis remains underused or inappropriately used. Our previous review suggested that system-wide interventions, such as education, alerts, and multifaceted interventions were more effective at improving the prescribing of thromboprophylaxis than relying on individual providers' behaviors...
April 24, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29686614/traditional-chinese-medicine-for-bradyarrhythmia-evidence-and-potential-mechanisms
#3
Shuo Liu, Guihua Tian, Jing Chen, Xiaoyu Zhang, Aiming Wu, Min Li, Yang Sun, Baoshan Liu, Yanwei Xing, Hongcai Shang
Importance: The incidence of Bradyarrhythmias is high among the population. However, at early stages of the disease, it cannot always get enough attention and is lack of safe and effective therapies, until it is serious enough to resort to pacemaker implantation. Traditional Chinese Medicine (TCM) has a long history of treating Bradyarrhythmia, with a lot of formulas being widely used in clinical practice. While the effectiveness and the underlying mechanisms of these formulas have not yet been clearly identified...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29685102/identification-of-novel-putative-causative-genes-and-genetic-marker-for-male-sterility-in-japanese-cedar-cryptomeria-japonica-d-don
#4
Kentaro Mishima, Tomonori Hirao, Miyoko Tsubomura, Miho Tamura, Manabu Kurita, Mine Nose, So Hanaoka, Makoto Takahashi, Atsushi Watanabe
BACKGROUND: Japanese cedar (Cryptomeria japonica) is an important tree for Japanese forestry. Male-sterile marker development in Japanese cedar would facilitate selection of male-sterile plus trees, addressing the widespread social problem of pollinosis and facilitating the identification of heterozygotes, which are useful for breeding. RESULTS: This study used next-generation sequencing for single-nucleotide polymorphism discovery in libraries constructed from several organs, including male-sterile and male-fertile strobili...
April 23, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29680443/a-systematic-review-and-meta-analysis-of-wound-drains-in-non-instrumented-lumbar-decompression-surgery
#5
REVIEW
Christopher L Davidoff, Jeffrey M Rogers, Mary Simons, Andrew S Davidson
Wound drains are routinely used in lumbar decompressive surgery (LDS). However, it remains unclear whether this practice helps to prevent symptomatic epidural hematoma formation and associated complications, particularly following non-instrumented procedures. A systematic review and meta-analysis was therefore completed to critically appraise the literature. The search protocol was conducted using the Ovid MEDLINE, EMBASE, Scopus, Cochrane Library, and Google Scholar databases. Articles meeting the following criteria were included: (i) examined patients undergoing LDS; (ii) included cases receiving post-operative wound drains; (iii) detailed adverse outcomes including symptomatic epidural hematomas or wound infection; and (iv) were published in English in a peer-reviewed journal...
April 18, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29679503/prosthetic-rehabilitation-of-patients-with-hypohidrotic-ectodermal-dysplasia-a-systematic-review
#6
REVIEW
Dagmar Schnabl, Ingrid Grunert, Matthias Schmuth, Ines Kapferer-Seebacher
BACKGROUND: Hypohidrotic ectodermal dysplasia (HED) comprises a large group of inherited disorders of ectodermal structures, characterized by hypo-/anhidrosis, hypotrichosis and hypo-/oligo-/anodontia. OBJECTIVE: We aimed to systematically assess the spectrum of prosthodontic approaches with regard to the patients' age and to provide clinical implications for practicing dentists. METHODS: An electronic and manual search was conducted in four databases (Medline, LIVIVO, Cochrane Library, Web of Science Core Collection)...
April 21, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29679215/diagnostic-role-of-serum-tryptase-in-anaphylactic-deaths-in-forensic-medicine-a-systematic-review-and-meta-analysis
#7
REVIEW
Kai-Jian Sun, Jie-Tao He, Hong-Yan Huang, Ye Xue, Xiao-Li Xie, Qi Wang
Postmortem diagnosis of sudden death due to anaphylaxis can be very difficult due to the non-specific pathological findings in forensic practice. Postmortem serum tryptase has been used as an indicator of possible ante-mortem anaphylaxis. Though many previous studies have been conducted to explore the diagnostic significance of serum tryptase for lethal anaphylaxis, inconsistent results were documented. In this study, we made a retrospective study and presented a systematic review and meta-analysis that aims to summarize the diagnostic significance of postmortem serum tryptase in the deceased with and without anaphylactic shock and to calculate a cutoff value for future reference in the identification of deaths due to anaphylactic shock...
April 21, 2018: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29678991/measurement-properties-of-the-health-of-the-nation-outcome-scales-honos-family-of-measures-protocol-for-a-systematic-review
#8
Meredith G Harris, Claudia Sparti, Roman Scheurer, Tim Coombs, Jane Pirkis, Torleif Ruud, Steve Kisely, Ketil Hanssen-Bauer, Johan Siqveland, Philip M Burgess
INTRODUCTION: The Health of the Nation Outcome Scales (HoNOS) for adults, and equivalent measures for children and adolescents and older people, are widely used in clinical practice and research contexts to measure mental health and functional outcomes. Additional HoNOS measures have been developed for special populations and applications. Stakeholders require synthesised information about the measurement properties of these measures to assess whether they are fit for use with intended service settings and populations and to establish performance benchmarks...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678965/parents-uptake-of-human-papillomavirus-vaccines-for-their-children-a-systematic-review-and-meta-analysis-of-observational-studies
#9
Peter A Newman, Carmen H Logie, Ashley Lacombe-Duncan, Philip Baiden, Suchon Tepjan, Clara Rubincam, Nick Doukas, Farid Asey
OBJECTIVE: To examine factors associated with parents' uptake of human papillomavirus (HPV) vaccines for their children. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Cochrane Library, AIDSLINE, CINAHL, EMBASE, PsycINFO, Social Sciences Abstracts, Ovid MEDLINE, Scholars Portal, Social Sciences Citation Index and Dissertation Abstracts International from inception through November 2017. METHODS: We included studies that sampled parents and assessed uptake of HPV vaccines for their children (≤18 years) and/or sociodemographics, knowledge, attitudes or other factors associated with uptake...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29677991/architecture-and-initial-development-of-a-knowledge-as-a-service-activator-for-computable-knowledge-objects-for-health
#10
Allen J Flynn, Peter Boisvert, Nate Gittlen, Colin Gross, Brad Iott, Carl Lagoze, George Meng, Charles P Friedman
The Knowledge Grid (KGrid) is a research and development program toward infrastructure capable of greatly decreasing latency between the publication of new biomedical knowledge and its widespread uptake into practice. KGrid comprises digital knowledge objects, an online Library to store them, and an Activator that uses them to provide Knowledge-as-a-Service (KaaS). KGrid's Activator enables computable biomedical knowledge, held in knowledge objects, to be rapidly deployed at Internet-scale in cloud computing environments for improved health...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29676960/psychotherapy-targeting-depression-and-anxiety-for-use-in-palliative-care-a-meta-analysis
#11
Jessica J Fulton, Amie R Newins, Laura S Porter, Katherine Ramos
BACKGROUND: Research on the effectiveness of evidence-based practices in the treatment of depression and anxiety with palliative care populations is primarily limited to individuals having specific conditions such as cancer. OBJECTIVE: This meta-analysis examined the effect of psychotherapy on depression and anxiety among individuals with any condition appropriate for palliative care. METHODS: We searched PubMed, PsycINFO, Cochrane Library, and EMBASE databases until August 2017...
April 20, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29672878/quality-of-life-in-patients-with-adrenal-disease-a-systematic-review
#12
Winnie Ho, Maralyn Druce
BACKGROUND: Evaluating the patient with adrenal disease is challenging due to the lack of precise clinical and biochemical parameters for disease control. Quality of Life (QOL) evaluation aims to measure the patient's subjective experience. OBJECTIVE: to describe how QOL is defined and measured in adrenal disease, critically appraise the use of QOL tools in published literature, discuss the implications of these findings and provide direction for further research in this field...
April 19, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29669625/a-generalized-approach-to-forensic-dye-identification-development-and-utility-of-reference-libraries
#13
Ethan Groves, Skip Palenik, Christopher S Palenik
While color is arguably the most important optical property of evidential fibers, the actual dyestuffs responsible for its expression in them are, in forensic trace evidence examinations, rarely analyzed and still less often identified. This is due, primarily, to the exceedingly small quantities of dye present in a single fiber as well as to the fact that dye identification is a challenging analytical problem, even when large quantities are available for analysis. Among the practical reasons for this are the wide range of dyestuffs available (and the even larger number of trade names), the low total concentration of dyes in the finished product, the limited amount of sample typically available for analysis in forensic cases, and the complexity of the dye mixtures that may exist within a single fiber...
April 18, 2018: Journal of AOAC International
https://www.readbyqxmd.com/read/29669089/what-works-and-does-not-work-in-a-self-management-intervention-for-people-with-chronic-pain-qualitative-systematic-review-and-meta-synthesis
#14
Hemakumar Devan, Leigh Hale, Dagmar Hempel, Barbara Saipe, Meredith A Perry
Background: Self-management interventions fostering self-efficacy improve the well-being of people with chronic pain. Purpose: The purpose of this study was to synthesize the enablers (what works) and barriers (what does not) of incorporating self-management strategies for people in everyday life after completion of a pain self-management intervention. Data Sources: Major electronic databases (MEDLINE, AMED, PsycINFO, Cochrane Library, PubMed, CINAHL, Scopus, and Google Scholar) were searched from inception to July 2016...
May 1, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29668895/evidence-to-improve-physical-activity-among-medically-underserved-older-adults-a-scoping-review
#15
Yi-Ling Hu, Kristin Junge, An Nguyen, Kelsey Hiegel, Emily Somerville, Marian Keglovits, Susan Stark
Background and Objectives: Participation in leisure physical activity (PA) and engagement in PA interventions among older adults is influenced by socioeconomic status (SES), race/ethnicity, and environment. However, studies of PA for medically underserved older adults have not yet been systematically evaluated. The objective of this study is to map the nature and extent of research conducted on PA participation, interventions, and components of effective leisure PA programs for medically underserved older adults...
April 16, 2018: Gerontologist
https://www.readbyqxmd.com/read/29668603/different-types-of-mesh-fixation-for-laparoscopic-repair-of-inguinal-hernia-a-protocol-for-systematic-review-and-network-meta-analysis-with-randomized-controlled-trials
#16
Kongyuan Wei, Cuncun Lu, Long Ge, Bei Pan, Huan Yang, Jinhui Tian, Nong Cao
BACKGROUND: Laparoscopic inguinal hernia repair has become a valid option for repair of an inguinal hernia. Due to there are several types of mesh fixation for laparoscopic repair of inguinal hernia. The study aims to assess and compare the efficacy of different types of mesh fixation for laparoscopic repair of inguinal hernia using network meta-analysis. METHODS: We will systematically search PubMed, EMBASE the Cochrane library, and Chinese Biomedical Literature Database from their inception to March 2018...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29667838/general-synthetic-strategy-for-libraries-of-supported-multicomponent-metal-nanoparticles
#17
Hui Yang, Siobhan J Bradley, Xin Wu, Andrew Chan, Geoffrey I N Waterhouse, Thomas Nann, Jian Zhang, Paul E Kruger, Shengqian Ma, Shane G Telfer
Nanoparticles comprising three or more different metals are challenging to prepare. General methods that tackle this challenge are highly sought after as multicomponent metal nanoparticles display favorable properties in applications such as catalysis, biomedicine, and imaging. Herein, we report a practical and versatile approach for the synthesis of nanoparticles composed of up to four different metals. This method relies on the thermal decomposition of nanostructured composite materials assembled from platinum nanoparticles, a metal-organic framework (ZIF-8), and a tannic acid coordination polymer...
April 18, 2018: ACS Nano
https://www.readbyqxmd.com/read/29666136/systematic-review-and-meta-analysis-of-diabetes-mellitus-cardiovascular-and-respiratory-condition-epidemiology-in-sexual-minority-women
#18
Catherine Meads, Adam Martin, Jeffrey Grierson, Justin Varney
OBJECTIVE: Sexual minority women (SMW) experience higher chronic disease risk factors than heterosexual counterparts. However, it was unclear if these risks translate into higher physical condition rates. This systematic review evaluates cardiovascular disease (CVD), hypertension, respiratory disease and diabetes mellitus in SMW. METHODS: A protocol was registered with the Prospero database (CRD42016050299). Included were studies reporting mortality, incidence or prevalence of the above-listed conditions in SMW compared with heterosexual women...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29666134/adoption-of-a-novel-surgical-innovation-into-clinical-practice-protocol-for-a-qualitative-systematic-review-examining-surgeon-views
#19
Thomas L Lewis, Hugh N Furness, George W Miller, Nicholas Parsons, Kate Seers, Martin Underwood, Andrew J Metcalfe
INTRODUCTION: Efficient adoption of clinically effective novel surgical innovations has great potential benefits for patients. Factors affecting the adoption of surgical innovation are not well understood and proposed models of adoption do not accurately correlate with historical evidence. This protocol is for a systematic review that aims to identify the qualitative evidence relating to surgeon views regarding the adoption of novel surgical innovation into clinical practice. METHODS AND ANALYSIS: A systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidance will be performed...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29664177/-osler-warned-was-william-osler-a-grave-robber-while-at-mcgill-or-was-he-a-victim-or-perpetrator-of-one-final-practical-joke
#20
James R Wright
Bodysnatching was an illegal way to procure cadavers for anatomical dissection before the existence of effective anatomy legislation. As knowledge of anatomy was fundamental to medical practice, many famous 19th century physicians turned a blind eye to this activity or even participated. Sir William Osler, perhaps the most revered physician of all time, received his medical degree from McGill University in 1872 and then served as pathologist at Montreal General Hospital from 1874 to 1884, where he began a career which culminated in him becoming both the first Professor of Medicine at Johns Hopkins and then Regius Professor at Oxford...
April 17, 2018: Clinical Anatomy
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