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https://www.readbyqxmd.com/read/29245000/does-traumatic-brain-injury-hold-the-key-to-the-alzheimer-s-puzzle
#1
Robert E Becker, Dimitrios Kapogiannis, Nigel H Greig
INTRODUCTION: Neurodegenerative disorders have been a graveyard for hundreds of well-intentioned efforts at drug discovery and development. Concussion and other traumatic brain injuries (TBIs) and Alzheimer's disease (AD) share many overlapping pathologies and possible clinical links. METHODS: We searched the literature since 1995 using MEDLINE and Google Scholar for the terms concussion, AD, and shared neuropathologies. We also studied a TBI animal model as a supplement to transgenic (Tg) mouse AD models for evaluating AD drug efficacy by preventing neuronal losses...
December 12, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29244989/global-use-of-traditional-and-complementary-medicine-in-childhood-cancer-a-systematic-review
#2
Caroline Diorio, Catherine G Lam, Elena J Ladas, Festus Njuguna, Glenn M Afungchwi, Katherine Taromina, Stacey Marjerrison
Purpose Traditional and complementary medicine (T&CM) strategies are commonly used in pediatric oncology. Patterns may vary based on country income. We systematically reviewed published studies describing T&CM use among pediatric oncology patients in low-income countries (LIC/LMIC), middle-income countries (UMIC), and high-income countries (HIC). Objectives included describing estimated prevalence of use, reasons for use, perceived effectiveness, modalities used, rates of disclosure, and reporting of delayed or abandoned treatment...
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29244969/treatment-of-open-upper-limb-injuries-with-infection-prevention-and-negative-pressure-wound-therapy-a-systematic-review
#3
E Ali, M Raghuvanshi
OBJECTIVE: Open upper limb injuries requiring soft reconstruction can pose a dilemma for trauma surgeons when considering the treatment options. The British Orthopaedic Association and British Association of Plastic, Reconstructive and Aesthetic Surgeons Standard for Trauma (BOAST) have addressed the management of severe open lower limb fractures with the creation of the BOAST 4 guidelines. However, no such gold standard exists for the treatment of open injuries of the upper limb. Furthermore, treatment of these injuries is often more difficult and requires complicated strategies...
December 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29244800/hla-dq-genetics-in-children-with-celiac-disease-a-meta-analysis-suggesting-a-two-step-genetic-screening-procedure-starting-with-hla-dq-%C3%AE-chains
#4
Annalisa De Silvestri, Cristina Capittini, Dimitri Poddighe, Chiara Valsecchi, Gianluigi Marseglia, Sara Carlotta Tagliacarne, Valeria Scotti, Chiara Rebuffi, Annamaria Pasi, Miryam Martinetti, Carmine Tinelli
OBJECTIVES: through a meta-analysis, evaluating the distribution of the predisposing HLA genotype to Celiac Disease (CD) in children and providing insights for potential widened screening strategy. STUDY DESIGN: After a systematic search on the association between HLA class II and CD in children, 46 publications were obtained and assessed for eligibility. 13 eligible studies were submitted to data extraction and analysis (10 studies case-control and 3 cohort studies)...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244479/discovery-of-intermetallic-compounds-from-traditional-to-machine-learning-approaches
#5
Anton O Oliynyk, Arthur Mar
Intermetallic compounds are bestowed by diverse compositions, complex structures, and useful properties for many materials applications. How metallic elements react to form these compounds and what structures they adopt remain challenging questions that defy predictability. Traditional approaches offer some rational strategies to prepare specific classes of intermetallics, such as targeting members within a modular homologous series, manipulating building blocks to assemble new structures, and filling interstitial sites to create stuffed variants...
December 15, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29244157/evaluation-of-lambda-cyhalothrin-and-pyriproxyfen-barrier-treatments-for-aedes-albopictus-diptera-culicidae-management-in-urbanized-areas-of-new-jersey
#6
Isik Unlu, Gregory M Williams, Ilia Rochlin, Devi Suman, Yi Wang, Kshitij Chandel, Randy Gaugler
Mosquito control programs in the United States are still searching for best management practices to control the Asian tiger mosquito, Aedes albopictus (Skuse; Diptera: Culicidae). Most intervention methods for this species are either labor intensive (e.g., source reduction) or short-term (e.g., ultra-low-volume adulticiding). We investigated the effectiveness of barrier spray pesticide applications within urban and suburban residential yards in New Jersey as a control strategy using a before-after-control-impact (BACI) approach...
December 13, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29243289/examining-the-content-and-moderators-of-women-s-fears-for-giving-birth-a-meta-synthesis
#7
REVIEW
Kayleigh Sheen, Pauline Slade
AIMS AND OBJECTIVES: This meta-synthesis aimed to identify key elements contributing to FOC derived from women's own reports. BACKGROUND: Fear of childbirth (FOC) encompasses fear or anxiety about giving birth, which can resemble a phobic response. FOC holds implications for women's antenatal and postnatal wellbeing, and decisions made about the birth but a clear definition of the construct does not exist. METHOD: A meta-synthesis was conducted by searching databases (Web of Knowledge, CINAHL, EBSCO, Medline, PsychInfo, and PsychArticles) for qualitative studies describing women's perspectives with respect to fear, anxiety, concerns, phobia or stress about birth...
December 15, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29243014/prognostic-value-of-lvedp-in-acute-myocardial-infarction-a-systematic-review-and-meta-analysis
#8
Stephen C Brienesse, Allan J Davies, Arshad Khan, Andrew J Boyle
Left ventricular end-diastolic pressure (LVEDP) is an easily obtained, physiologically integrative measure of total LV function. LVEDP may be a useful prognostic measure in patients with acute myocardial infarction and utilised to guide medical therapy and assess risk for post myocardial infarction heart failure. To assess the utility of LVEDP as a prognostic measure in patients presenting with acute myocardial infarction. We performed an unrestricted search of electronic databases (1946 to March 2017) using a predefined search strategy...
December 14, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29242595/germline-brca-mutation-in-male-carriers-ripe-for-precision-oncology
#9
REVIEW
Ricardo Romão Nazário Leão, Aryeh Joshua Price, Robert James Hamilton
BACKGROUND: Prostate cancer (PC) is one of the known heritable cancers with individual variations attributed to genetic factors. BRCA1 and BRCA2 are tumour suppressor genes with crucial roles in repairing DNA and thereby maintaining genomic integrity. Germline BRCA mutations predispose to multiple familial tumour types including PC. METHODS: We performed a Pubmed database search along with review of reference lists from prominent articles to capture papers exploring the association between BRCA mtuations and prostate cancer risk and prognosis...
December 14, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29242073/abbreviated-atovaquone-proguanil-prophylaxis-regimens-in-travellers-after-leaving-malaria-endemic-areas-a-systematic-review
#10
Jelmer Savelkoel, Klaas Hendrik Binnendijk, Rene Spijker, Michèle van Vugt, Kathrine Tan, Thomas Hänscheid, Patricia Schlagenhauf, Martin Peter Grobusch
BACKGROUND: We evaluated existing data on the prophylactic efficacy of atovaquone-proguanil (AP) in order to determine whether prophylaxis in travellers can be discontinued on the day of return from a malaria-endemic area instead of seven days after return as per currently recommended post-travel schedule. METHODS: PubMed and Embase databases were searched to identify relevant studies. This PROSPERO-registered systematic review followed PRISMA guidelines. The search strategy included terms or synonyms relevant to AP combined with terms to identify articles relating to prophylactic use of AP and inhibitory and half-life properties of AP...
December 11, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29241711/l-carnitine-and-heart-disease
#11
REVIEW
Zhong-Yu Wang, Ying-Yi Liu, Guo-Hui Liu, Hai-Bin Lu, Cui-Ying Mao
Cardiovascular disease (CVD) is a key cause of deaths worldwide, comprising 15-17% of healthcare expenditure in developed countries. Current records estimate an annual global average of 30 million cardiac dysfunction cases, with a predicted escalation by two-three folds for the next 20-30years. Although β-blockers and angiotensin-converting-enzymes are commonly prescribed to control CVD risk, hepatotoxicity and hematological changes are frequent adverse events associated with these drugs. Search for alternatives identified endogenous cofactor l-carnitine, which is capable of promoting mitochondrial β-oxidation towards a balanced cardiac energy metabolism...
December 11, 2017: Life Sciences
https://www.readbyqxmd.com/read/29241699/sterile-water-injections-for-childbirth-pain-an-evidenced-based-guide-to-practice
#12
Lena B Mårtensson, Eileen K Hutton, Nigel Lee, Sue Kildea, Yu Gao, Ingrid Bergh
BACKGROUND: About 30% of women in labour suffer from lower back pain. Studies of sterile water injections for management of low back pain have consistently shown this approach to be effective. The objective of this evidence-based guide is to facilitate the clinical use of sterile water injections to relieve lower back pain in labouring women. METHODS: To identify relevant publications our search strategy was based on computerised literature searches in scientific databases...
December 11, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29241686/rankl-and-rank-from-mammalian-physiology-to-cancer-treatment
#13
REVIEW
Shuan Rao, Shane J F Cronin, Verena Sigl, Josef M Penninger
The tumor necrosis factor (TNF) receptor RANK (TNFRSF11A) and its ligand RANKL (TNFSF11) regulate osteoclast development and bone metabolism. They also control stem cell expansion and proliferation of mammary epithelial cells via the sex hormone progesterone. As such, RANKL and RANK have been implicated in the onset of hormone-induced breast cancer. Recently, RANK/RANKL were identified as crucial regulators for BRCA1 mutation-driven breast cancer. Current prevention strategies for BRCA1 mutation carriers are associated with wide-ranging risks; therefore, the search for alternative, non-invasive strategies is of paramount importance...
December 11, 2017: Trends in Cell Biology
https://www.readbyqxmd.com/read/29241672/catatonia-with-schizophrenia-from-ect-to-rtms
#14
E Stip, M-E Blain-Juste, O Farmer, M-P Fournier-Gosselin, P Lespérance
BACKGROUND: Electroconvulsive therapy is indicated in cases of catatonic schizophrenia following a failure of the challenge test with lorazepam or Zolpidem®. Some patients need maintenance treatment with ECT. Repetitive Transcranial Magnetic Stimulation (rTMS) and anodal Transcranial direct-current stimulation (tDCS) might be effective against catatonia. OBJECTIVE: Consider an alternative to ECT for a refractory patient. REVIEW: Twenty-one articles were identified mainly based on case reports series were found using search on Medline, Google Scholar, PsychInfo, CAIRNS...
December 11, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29241435/potential-benefits-of-incorporating-peer-to-peer-interactions-into-digital-interventions-for-psychotic-disorders-a-systematic-review
#15
Bruno Biagianti, Sophia H Quraishi, Danielle A Schlosser
OBJECTIVE: Peer-to-peer interactions and support groups mitigate experiences of social isolation and loneliness often reported by individuals with psychotic disorders. Online peer-to-peer communication can promote broader use of this form of social support. Peer-to-peer interactions occur naturally on social media platforms, but they can negatively affect mental health. Recent digital interventions for persons with psychotic disorders have harnessed the principles of social media to incorporate peer-to-peer communication...
December 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29241366/accuracy-of-dental-development-for-estimating-the-pubertal-growth-spurt-in-comparison-to-skeletal-development-a-systematic-review-and-meta-analysis
#16
Marcos Av Bittencourt, Graziela O Cericato, Ademir Franco, Rafaela S Girão, Anderson Pb Lima, Luiz R Paranhos
OBJECTIVES: This study aimed to search for scientific evidence concerning the accuracy of dental development for estimating the pubertal growth spurt. METHODS: It was conducted according to the statements of PRISMA. An electronic search was performed in six databases, including the grey literature. The PICOS strategy was used to define the eligibility criteria and only observational studies were selected. RESULTS: Out of 1,416 identified citations, ten papers fulfilled the criteria and were included in this systematic review...
December 15, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/29241195/nursing-intervention-on-the-compliance-of-hemodialysis-patients-with-end-stage-renal-disease-a-meta-analysis
#17
Jing Wang, Peng Yue, Jing Huang, Xiaodong Xie, Yunhua Ling, Li Jia, Yunjin Xiong, Fang Sun
BACKGROUND: Dialysis is imperative for patients with end-stage renal disease (ESRD); however, compliance ensures its efficacy. Nursing intervention has been considered to improve compliance. This meta-analysis is aimed at exploring the effects of nursing intervention on dialysis compliance. METHODS: A search was performed in the PubMed, Cochrane, and Embase databases for relevant original research articles. Studies were included or excluded based on the simultaneous consideration of quality as ranked by Jadad score and the compliance with predefined selection criteria...
December 12, 2017: Blood Purification
https://www.readbyqxmd.com/read/29240899/patient-perceptions-of-receiving-test-results-via-online-portals-a-mixed-methods-study
#18
Traber D Giardina, Jessica Baldwin, Daniel T Nystrom, Dean F Sittig, Hardeep Singh
Objective: Online portals provide patients with access to their test results, but it is unknown how patients use these tools to manage results and what information is available to promote understanding. We conducted a mixed-methods study to explore patients' experiences and preferences when accessing their test results via portals. Materials and Methods: We conducted 95 interviews (13 semistructured and 82 structured) with adults who viewed a test result in their portal between April 2015 and September 2016 at 4 large outpatient clinics in Houston, Texas...
December 12, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29240813/feature-reliability-determines-specificity-and-transfer-of-perceptual-learning-in-orientation-search
#19
Amit Yashar, Rachel N Denison
Training can modify the visual system to produce a substantial improvement on perceptual tasks and therefore has applications for treating visual deficits. Visual perceptual learning (VPL) is often specific to the trained feature, which gives insight into processes underlying brain plasticity, but limits VPL's effectiveness in rehabilitation. Under what circumstances VPL transfers to untrained stimuli is poorly understood. Here we report a qualitatively new phenomenon: intrinsic variation in the representation of features determines the transfer of VPL...
December 14, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29239942/targeted-temperature-management-after-cardiac-arrest-systematic-review-and-meta-analyses
#20
Rajat Kalra, Garima Arora, Nirav Patel, Rajkumar Doshi, Lorenzo Berra, Pankaj Arora, Navkaranbir S Bajaj
BACKGROUND: Targeted temperature management (TTM) with therapeutic hypothermia is an integral component of postarrest care for survivors. However, recent randomized controlled trials (RCTs) have failed to demonstrate the benefit of TTM on clinical outcomes. We sought to determine if the pooled data from available RCTs support the use of prehospital and/or inhospital TTM after cardiac arrest. METHODS: A comprehensive search of SCOPUS, Elsevier's abstract and citation database of peer-reviewed literature, from 1966 to November 2016 was performed using predefined criteria...
December 11, 2017: Anesthesia and Analgesia
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