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https://www.readbyqxmd.com/read/29471597/-clinical-study-of-2014-isup-new-grade-group-classification-for-prostate-cancer-patients-treated-by-androgen-deprivation-therapy
#1
Masahiro Uno, Makoto Kawase, Daiki Kato, Takashi Ishida, Seiichi Kato, Yoshinori Fujimoto
The 2014 International Society of Urological Pathology (ISUP) has proposed a new grade group (GG) classification for Gleason scores (GS). The usefulness of the new GG classification was investigated with 518 prostate cancer patients who underwent androgen deprivation therapy. According to the new GG classification, Stages B‒D and the new GG classification relapse-free rate for each stage were calculated using the Kaplan‒Meier method. The new GG classification revealed a significant difference for the relapse-free rate only between some groups...
January 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29471457/improving-anatomic-pathology-in-sub-saharan-africa-to-support-cancer-care
#2
Michael L Wilson, Stephanie Ayers, Daniel Berney, Alexia Eslan, Jeannette Guarner, Susan Lester, Ricard Masia, Zahir Moloo, Angela Mutuku, Drucilla Roberts, Jennifer Stall, Shahin Sayed
Objectives: Cancer care requires both accurate pathologic diagnosis as well as pathologic cancer staging. We evaluated three approaches to training pathologists in sub-Saharan Africa to perform pathologic cancer staging of breast, cervix, prostate, and colorectal cancers. Methods: One of three training methods was used at each workshop: didactic, case-based testing (CBT), or a blended approach. The project involved 52 participants from 16 pathology departments in 11 countries in East, Central, and Southern Africa...
February 19, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29471417/a-study-of-circulating-micrornas-identifies-a-new-potential-biomarker-panel-to-distinguish-aggressive-prostate-cancer
#3
Batoul Farran, Gregory Dyson, Douglas Craig, Alan Dombkowski, Jennifer L Beebe-Dimmer, Isaac J Powell, Izabela Podgorski, Lance Heilbrun, Susan Bolton, Cathryn H Bock
Prostate cancer is one of the most common cancers in men worldwide. Currently available diagnostic and prognostic tools for this disease, such as PSA, suffer from lack of specificity and sensitivity, resulting in over- and misdiagnosis. Hence, there is an urgent need for clinically relevant biomarkers capable of distinguishing between aggressive and non-aggressive forms of prostate cancer to aid in stratification, management and therapeutic decisions. To address this unmet need, we investigated the patterns of expression of a panel of 68 plasma-derived microRNAs (miRNAs) in a cohort of African American (AA) and European American (EA) prostate cancer patients (n=114)...
February 17, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29471119/enediynes-bearing-polyfluoroaryl-sulfoxide-as-new-antiproliferative-agents-with-dual-targeting-of-microtubules-and-dna
#4
Cyril Borie, Shovan Mondal, Tanzeel Arif, Manon Briand, Hugo Lingua, Frédéric Dumur, Didier Gigmes, Pierre Stocker, Bernadette Barbarat, Viviane Robert, Cendrine Nicoletti, Daniel Olive, Marc Maresca, Malek Nechab
A novel series of enediynes possessing pentafluorophenylsulfoxide have been developed. The innovative compounds possess antiproliferative activity against a broad panel of human cancer cells originating from breast, blood, lung, kidney, colon, prostate, pancreas or skin with IC50 ranging from 0.6 to 3.4 μM. The antiproliferative activity of enediynes in darkness is associated to their ability to compromise microtubule network. In addition, exposure to UV leads to double-stranded DNA cleavage caused by the newly synthesized molecules reducing further their IC50 in nanomolar range against human tumor cells, including chemo-resistant pancreatic cancer cells...
February 12, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29471004/prostate-cancer-chemoprevention-by-natural-agents-clinical-evidence-and-potential-implications
#5
Gagan Chhabra, Chandra K Singh, Mary Ann Ndiaye, Samantha Fedorowicz, Arielle Molot, Nihal Ahmad
Prostate cancer (PCa) is the most common non-skin cancer and the second leading cause of cancer-related deaths in American men. Due to its long latency period, PCa is considered as an ideal cancer type for chemopreventive interventions. Chemopreventive agents include various natural or synthetic agents that prevent or delay cancer development, progression and/or recurrence. Pre-clinical studies suggest that many natural products and dietary agents have chemopreventive properties. However, a limited number of these agents have been tested in clinical trials, with varying success...
February 19, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29470623/long-distance-longitudinal-prostate-mri-quality-assurance-from-startup-to-12-months
#6
Nicole E Curci, Patrick Gartland, Prasad R Shankar, Jeffrey S Montgomery, David C Miller, Arvin K George, Matthew S Davenport
PURPOSE: To evaluate a 12-month long-distance prostate MRI quality assurance (QA) program. METHODS: The need for IRB approval was waived for this prospective longitudinal QA effort. One academic institution experienced with prostate MRI [~ 1000 examinations/year (Site 2)] partnered with a private institution 240 miles away that was starting a new prostate MRI program (Site 1). Site 1 performed all examinations (N = 249). Four radiologists at Site 1 created finalized reports, then sent images and reports to Site 2 for review on a rolling basis...
February 22, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29470576/navigating-prostate-cancer-screening-in-the-real-world-of-primary-care-the-mirage-and-the-quicksand
#7
Paul Mathew, Hilal Hachem, Paul Han
No abstract text is available yet for this article.
February 22, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29470572/prostate-specific-membrane-antigen-positron-emission-tomography-computed-tomography-in-locally-advanced-recurrent-and-metastatic-prostate-cancer-reply
#8
Liza Lindenberg, Baris Turkbey, Peter Choyke
No abstract text is available yet for this article.
February 22, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29470570/a-magnetic-resonance-imaging-based-prediction-model-for-prostate-biopsy-risk-stratification
#9
Sherif Mehralivand, Joanna H Shih, Soroush Rais-Bahrami, Aytekin Oto, Sandra Bednarova, Jeffrey W Nix, John V Thomas, Jennifer B Gordetsky, Sonia Gaur, Stephanie A Harmon, Mohummad Minhaj Siddiqui, Maria J Merino, Howard L Parnes, Bradford J Wood, Peter A Pinto, Peter L Choyke, Baris Turkbey
Importance: Multiparametric magnetic resonance imaging (MRI) in conjunction with MRI-transrectal ultrasound (TRUS) fusion-guided biopsies have improved the detection of prostate cancer. It is unclear whether MRI itself adds additional value to multivariable prediction models based on clinical parameters. Objective: To determine whether an MRI-based prediction model can reduce unnecessary biopsies in patients with suspected prostate cancer. Design, Setting, and Participants: Patients underwent MRI, MRI-TRUS fusion-guided biopsy, and 12-core systematic biopsy in 1 session...
February 22, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29470569/prostate-specific-membrane-antigen-positron-emission-tomography-computed-tomography-in-locally-advanced-recurrent-and-metastatic-prostate-cancer
#10
Marlon Perera, Declan Murphy, Nathan Lawrentschuk
No abstract text is available yet for this article.
February 22, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29470068/a-potent-epha2-agonistic-peptide-drug-conjugate-reduces-circulating-cancer-cells-and-metastases-in-breast-cancer-models
#11
Ahmed F Salem, Si Wang, Sandrine Billet, Jie-Fu Chen, Parima Udompholkul, Luca Gambini, Carlo Baggio, Hsian-Rong Tseng, Edwin M Posadas, Neil A Bhowmick, Maurizio Pellecchia
EphA2 overexpression has been associated with metastasis of multiple cancer types, including melanoma, ovarian, prostate, lung, and breast cancer. We have recently proposed to develop peptide-drug conjugates (PDCs) using agonistic EphA2-targeting agents such as the YSA peptide or its optimized version 123B9. While our studies indicated that YSA- or 123B9-drug conjugates can selectively deliver cytotoxic drugs to cancer cells in vivo, the relatively low cellular agonistic activity (high micromolar) of the agents for the EphA2 receptor remained a limiting factor to warrant further development of these PDCs in the clinic...
February 22, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29469937/radiomic-features-on-mri-enable-risk-categorization-of-prostate-cancer-patients-on-active-surveillance-preliminary-findings
#12
Ahmad Algohary, Satish Viswanath, Rakesh Shiradkar, Soumya Ghose, Shivani Pahwa, Daniel Moses, Ivan Jambor, Ronald Shnier, Maret Böhm, Anne-Maree Haynes, Phillip Brenner, Warick Delprado, James Thompson, Marley Pulbrock, Andrei S Purysko, Sadhna Verma, Lee Ponsky, Phillip Stricker, Anant Madabhushi
BACKGROUND: Radiomic analysis is defined as computationally extracting features from radiographic images for quantitatively characterizing disease patterns. There has been recent interest in examining the use of MRI for identifying prostate cancer (PCa) aggressiveness in patients on active surveillance (AS). PURPOSE: To evaluate the performance of MRI-based radiomic features in identifying the presence or absence of clinically significant PCa in AS patients. STUDY TYPE: Retrospective...
February 22, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29469641/castrate-resistant-prostate-cancer-lessons-learnt-from-a-pilot-study-in-the-palliative-care-research-population
#13
Karyn A Sullivan, Ngaire Kingi, Phillip Good, Petra Vayne-Bossert, Janet R Hardy
BACKGROUND: Palliative care patients are inherently difficult to recruit to and retain on studies. Even when patients are recruited, it is hard to complete studies with sufficient data. There is a dearth of literature specific to men with castrate resistant prostate cancer (CRPC) and the clinical trials coordinator/research nurse's perspective in improving trial outcomes in palliative care. Objectives To describe the lessons learnt (by the nursing research team) from a prospective cohort study of men with CRPC and the practical implications for future research in this area...
February 2, 2018: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/29469070/utilization-of-pelvic-lymph-node-dissection-in-patients-undergoing-robot-assisted-radical-prostatectomy-in-india-versus-the-united-states-a-vattikuti-collective-quality-initiative-database-analysis
#14
F Abdollah, S Arora, T Jindal, P Gild, A Sood, T B Yuvaraja, R K Ahlawat, N P Gupta, M Bhandari, M Menon
BACKGROUND: The utilization and extent of pelvic lymph node dissection (PLND) varies depending on the disease and practice patterns. AIMS: This study compares practice patterns in utilization of PLND between Indian and United States (US) practices. SETTINGS AND DESIGN: We focused on 415 patients (204 India; 211 US) prostate cancer patients treated with robot-assisted radical prostatectomy, between 2015 and 2016, within the Vattikuti Collective Quality Initiative database...
April 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29468843/gpcr6a-is-a-molecular-target-for-the-natural-products-gallate-and-egcg-in-green-tea
#15
Min Pi, Karan Kapoor, Ruisong Ye, Jeremy C Smith, Jerome Baudry, L Darryl Quarles
SCOPE: The molecular mechanisms whereby gallates in green tea exert metabolic effects are poorly understood. METHODS AND RESULTS: We found that GPRC6A, a multi-ligand sensing G-protein coupled receptor that regulates energy metabolism, sex hormone production and prostate cancer progression, is a target for gallates. Sodium gallate,1 gallic acid (GA) > ethyl gallate (EG) > octyl gallate (OG) dose dependently activated ERK in HEK-293 cells transfected with GPRC6A but not in non-transfected controls...
February 21, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29468607/the-patient-reported-information-multidimensional-exploration-prime-framework-for-investigating-emotions-and-other-factors-of-prostate-cancer-patients-with-low-intermediate-risk-based-on-online-cancer-support-group-discussions
#16
Tharindu Bandaragoda, Weranja Ranasinghe, Achini Adikari, Daswin de Silva, Nathan Lawrentschuk, Damminda Alahakoon, Raj Persad, Damien Bolton
BACKGROUND: This study aimed to use the Patient Reported Information Multidimensional Exploration (PRIME) framework, a novel ensemble of machine-learning and deep-learning algorithms, to extract, analyze, and correlate self-reported information from Online Cancer Support Groups (OCSG) by patients (and partners of patients) with low intermediate-risk prostate cancer (PCa) undergoing radical prostatectomy (RP), external beam radiotherapy (EBRT), and active surveillance (AS), and to investigate its efficacy in quality-of-life (QoL) and emotion measures...
February 21, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29468501/resolution-and-assignment-of-differential-ion-mobility-spectra-of-sarcosine-and-isomers
#17
Francis Berthias, Belkis Maatoug, Gary L Glish, Fathi Moussa, Philippe Maitre
Due to their central role in biochemical processes, fast separation and identification of amino acids (AA) is of importance in many areas of the biomedical field including the diagnosis and monitoring of inborn errors of metabolism and biomarker discovery. Due to the large number of AA together with their isomers and isobars, common methods of AA analysis are tedious and time-consuming because they include a chromatographic separation step requiring pre- or post-column derivatization. Here, we propose a rapid method of separation and identification of sarcosine, a biomarker candidate of prostate cancer, from isomers using differential ion mobility spectrometry (DIMS) interfaced with a tandem mass spectrometer (MS/MS) instrument...
February 21, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29468311/-68-ga-psma-pet-ct-imaging-of-localized-primary-prostate-cancer-patients-for-intensity-modulated-radiation-therapy-treatment-planning-with-integrated-boost
#18
Lena Thomas, Steffi Kantz, Arthur Hung, Debra Monaco, Florian C Gaertner, Markus Essler, Holger Strunk, Wolfram Laub, Ralph A Bundschuh
PURPOSE: The purpose of our study was to show the feasibility and potential benefits of using68 Ga-PSMA-PET/CT imaging for radiation therapy treatment planning of patients with primary prostate cancer using either integrated boost on the PET-positive volume or localized treatment of the PET-positive volume. The potential gain of such an approach, the improvement of tumor control, and reduction of the dose to organs-at-risk at the same time was analyzed using the QUANTEC biological model...
February 21, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29468200/robot-assisted-perineal-radical-prostatectomy-in-a-post-kidney-transplant-recipient
#19
Volkan Tugcu, Abdulmuttalip Simsek, Ismail Yigitbasi, Mustafa Gurkan Yenice, Selcuk Sahin, Ali Ihsan Tasci
Background: After almost two decades, transabdominal robotic radical prostatectomy techniques have been fully developed and are widely practiced by many robotic urologists. Recently, a transperineal robotic radical prostatectomy, a technique not yet popular to many, was introduced as an alternative approach in patients with previous abdominal surgery. Here, we present our unique experience with robotic perineal radical prostatectomy (r-PRP) on a kidney transplant recipient. Case Presentation: A 71-year-old man who had a kidney transplant 4 months previously was diagnosed with prostate cancer (PCa) and underwent r-PRP using the da Vinci Xi robotic system...
2018: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29467956/vitamin-d-receptor-taq-i-polymorphism-and-the-risk-of-prostate-cancer-a-meta-analysis
#20
Shaosan Kang, Yansheng Zhao, Lei Wang, Jian Liu, Xi Chen, Xiaofeng Liu, Zhijie Shi, Weixing Gao, Fenghong Cao
Numerous previous studies reported the association of Vitamin D receptor gene Taq I polymorphism with prostate cancer risk, however these results were controversial. In order to provide a relatively comprehensive description of this relationship, we conducted this meta-analysis by searching PubMed, Embase, and China National Knowledge Infrastructure. Finally, 36 studies with 8,423 cases and 8,887 controls were included. Taq I polymorphism was found to marginally increase the prostate cancer risk in recessive genetic model (tt/Tt vs...
January 23, 2018: Oncotarget
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