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https://www.readbyqxmd.com/read/29055290/a-qualitative-meta-synthesis-examining-the-role-of-women-in-african-american-men-s-prostate-cancer-screening-and-treatment-decision-making
#1
REVIEW
Erin M Bergner, Emily K Cornish, Kenay Horne, Derek M Griffith
OBJECTIVE: Being an African American man is a risk factor for prostate cancer and there is little consensus about the utility of screening, early detection, and the efficacy of treatment for the disease. In this context, this systematic review examines the roles women, particularly wives, play in African American men's prostate cancer screening and treatment decision-making. METHODS: We searched OVID Medline (R), CINAHL (EBSCO), PsychInfo (EBSCO), PubMED, Cochrane Library, ERIC (Firstsearch) and Web of Science to identify peer-review articles published between 1980-2016 that reported qualitative data about prostate cancer screening, diagnosis, or treatment in African American men...
October 21, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29055286/in-defense-of-progesterone-a-review-of-the-literature
#2
Allan Lieberman, Luke Curtis
Context • The medical literature on the use of progesterone in postmenopausal women is often confusing and contradictory. Some physicians implicate natural progesterone in an increase in the risk of breast cancer. The chemical structure of natural progesterone (P4) is quite different from chemically altered, synthetic chemicals called progestins, which results in different actions at the cell level. Objective • The research team intended to review the literature to examine the benefits and safety of natural progesterone and determine whether it can cause an increase or decrease in breast cancer risk...
October 21, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29055100/optical-emission-of-223-radium-in-vitro-and-in-vivo-preclinical-applications
#3
Federico Boschi, Francesco De Sanctis, Antonello E Spinelli
(223) Radium ((223) Ra) is widely used in Nuclear medicine to treat patients with osseous metastatic prostate cancer. In clinical practice (223) Ra cannot be imaged directly, however gamma photons produced by its short-lived daughter nuclides can be captured by conventional gamma cameras. In this work we show that (223) Ra and its short-lived daughter nuclides can be detected with optical imaging techniques. The light emission of (223) Ra was investigated in vitro using different setups in order to clarify the mechanism of light production...
October 20, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29054883/the-role-of-patient-and-physician-advocacy-in-reducing-wait-times-for-cancer-care-a-qualitative-analysis
#4
Maria Mathews, Donna Bulman, Dana Ryan
BACKGROUND: There is growing interest in the role of physician as health advocate; however, few studies have documented advocacy from the patient's perspective. To address this gap, we examined the experiences of patients with cancer from the onset of symptoms to the start of treatment in Newfoundland and Labrador and aimed to describe wait times and efforts to improve timeliness of care from the patients' perspective. METHODS: We conducted qualitative interviews with 60 participants aged 19 years or more with breast, colorectal, lung or prostate cancer who were recruited from a survey of patients with cancer that was carried out as an earlier part of a larger study...
October 17, 2017: CMAJ Open
https://www.readbyqxmd.com/read/29054792/-management-of-prostate-cancer-in-patients-older-than-75%C3%A2-years
#5
Pierre Mongiat-Artus, Danièle Avenin
Prostate cancer is a disease of the elderly men. Prostate cancer in the elderly men is often poorly managed and under-treated. The digital rectal examination is an effective screening test for elderly prostate cancer patients. In order to choose the appropriated therapeutic option, evaluation of life-expectancy is essential to offer an optimal individualized treatment. It is essential to take into account the patients' aspirations before starting any diagnostic and therapeutic approach. Therapeutic options should be adapted in elderly prostate cancer patients according to their comorbidities and needs...
October 17, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29054500/re-impact-of-radical-prostatectomy-on-long-term-oncologic-outcomes-in-a-matched-cohort-of-men-with-pathological-node-positive-prostate-cancer-managed-by-castration
#6
Daniel W Good, Alan S McNeill
No abstract text is available yet for this article.
October 17, 2017: European Urology
https://www.readbyqxmd.com/read/29054497/association-between-male-pattern-baldness-and-prostate-disease-a-meta-analysis
#7
Tao Jin, Tao Wu, Zhumei Luo, Xi Duan, Shi Deng, Yin Tang
BACKGROUND: Male pattern baldness (MPB) has been associated with an increased risk of prostate cancer (PC) as well as benign prostatic hyperplasia (BPH). We performed a meta-analysis to quantitatively determine the level of risk of PC and BPH in individuals with baldness. METHODS: A systematic literature search was conducted using several databases. We calculated pooled odds ratios (OR) and 95% CIs. RESULTS: In total, 17 studies comprising 68,448 participants were eligible for the meta-analysis and showed that MPB is associated with an increased risk of aggressive PC (OR = 1...
October 17, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29054496/cancer-immunotherapy-a-paradigm-shift-in-the-treatment-of-advanced-urologic-cancers
#8
REVIEW
David M Gill, Neeraj Agarwal
The recent resurgence of immunotherapy has transformed the therapeutic field of advanced urologic cancers. In this seminars issue, we evaluate the role of emerging and recently approved immunotherapeutic agents in advanced prostate, urothelial, and renal cell carcinoma. In each of these fields, we discuss recent regulatory approvals as well as promising ongoing clinical trials. Finally, we discuss incidence and management of immune related adverse events specifically associated with PD-1/PD-L1 inhibitors.
October 17, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29054414/the-epidemiology-of-selenium-and-human-cancer
#9
Marco Vinceti, Tommaso Filippini, Silvia Cilloni, Catherine M Crespi
The relation between selenium and cancer has been one of the most hotly debated topics in human health over the last decades. Early observational studies reported an inverse relation between selenium exposure and cancer risk. Subsequently, randomized controlled trials showed that selenium supplementation does not reduce the risk of cancer and may even increase it for some types, including advanced prostate cancer and skin cancer. An increased risk of diabetes has also been reported. These findings have been consistent in the most methodologically sound trials, suggesting that the early observational studies were misleading...
2017: Advances in Cancer Research
https://www.readbyqxmd.com/read/29054374/comparative-analysis-of-clinical-outcomes-and-procedural-costs-between-the-conventional-two-stage-technique-and-4d-brachytherapy-for-early-prostate-cancer
#10
S E M Langley, J Uribe, S Uribe-Lewis, J Money-Kyrle, C Perna, S Khaksar, R Soares, R Laing
AIMS: To assess long-term outcomes and resource use of 4D Brachytherapy, a one-stage real-time implant for the treatment of prostate cancer that uses stranded and loose iodine-125 seeds, and to compare with the conventional two-stage (2S) technique. MATERIALS AND METHODS: Prospectively collected data of men who underwent 2S and 4D low dose rate brachytherapy in a single institution were analysed. Survival estimates were analysed using the Kaplan-Meier method and Log-rank test...
October 18, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29054337/dental-pulp-stem-cells-dpscs-increase-prostate-cancer-cell-proliferation-and-migration-under-in-vitro-conditions
#11
Ayşegül Doğan, Selami Demirci, Hüseyin Apdik, Ezgi Avşar Apdik, Fikrettin Şahin
Cancer as a multistep and complicated disease is regulated by several molecular and cellular events. Cancer treatment could be managed at the early stages when the tumor is confined in the tissue. However, disseminated cancer cells metastasize to other body parts and generate new tumors resulting in mortality. Mesenchymal stem cells (MSCs) are found in different body parts and helps adult tissue regeneration. The role of MSCs in cancer progression has emerged as one of the important aspects in cancer biology and is the aim of interest in recent years...
October 16, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/29053897/scientists-investigate-the-application-of-immunotherapy-to-many-cancer-sites-breast-and-prostate-cancers-prove-more-challenging-but-progress-is-occurring
#12
https://www.readbyqxmd.com/read/29053678/assay-for-phosphorylation-and-microtubule-binding-along-with-localization-of-tau-protein-in-colorectal-cancer-cells
#13
Md Nazmul Huda, Erdenedolgor Erdene-Ochir, Cheol-Ho Pan
The microtubule-associated protein tau is a neuronal protein that localizes mostly in axons. Generally tau is essential for normal neuronal functioning because it is involved in microtubule assembly and stabilization. Besides neurons, tau is expressed in human breast, prostate, gastric, colorectal, and pancreatic cancers where it shows nearly similar structure and exerts similar functions as the neuronal tau. The amount of tau and its phosphorylation can change its function as a stabilizer of microtubules, and lead to the development of paired helical filaments in different neurodegenerative disorders, such as Alzheimer's disease...
October 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29053613/advances-in-biomarkers-for-pca-diagnostics-and-prognostics-a-way-towards-personalized-medicine
#14
EDITORIAL
Carsten Stephan, Klaus Jung
Prostate cancer (PCa) is, with an estimated number of 161,360 cases and 26,730 deaths in 2017, the most common malignancy in the USA [...].
October 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29053402/what-are-we-missing-false-negative-cancers-at-multiparametric-mr-imaging-of-the-prostate
#15
Samuel Borofsky, Arvin K George, Sonia Gaur, Marcelino Bernardo, Matthew D Greer, Francesca V Mertan, Myles Taffel, Vanesa Moreno, Maria J Merino, Bradford J Wood, Peter A Pinto, Peter L Choyke, Baris Turkbey
Purpose To characterize clinically important prostate cancers missed at multiparametric (MP) magnetic resonance (MR) imaging. Materials and Methods The local institutional review board approved this HIPAA-compliant retrospective single-center study, which included 100 consecutive patients who had undergone MP MR imaging and subsequent radical prostatectomy. A genitourinary pathologist blinded to MP MR findings outlined prostate cancers on whole-mount pathology slices. Two readers correlated mapped lesions with reports of prospectively read MP MR images...
October 20, 2017: Radiology
https://www.readbyqxmd.com/read/29053177/early-effect-of-medicare-shared-savings-program-accountable-care-organization-participation-on-prostate-cancer-care
#16
Tudor Borza, Samuel R Kaufman, Phyllis Yan, Lindsey A Herrel, Amy N Luckenbaugh, David C Miller, Ted A Skolarus, Bruce L Jacobs, John M Hollingsworth, Edward C Norton, Vahakn B Shahinian, Brent K Hollenbeck
BACKGROUND: Accountable care organizations (ACOs) can improve prostate cancer care by decreasing treatment variations (ie, avoidance of treatment in low-value settings). Herein, the authors performed a study to understand the effect of Medicare Shared Savings Program ACOs on prostate cancer care. METHODS: Using a 20% Medicare sample, the authors identified men with newly diagnosed prostate cancer from 2010 through 2013. Rates of treatment, potential overtreatment (ie, treatment in men with a ≥75% chance of 10-year mortality from competing risks), and Medicare payments were measured using regression models...
October 20, 2017: Cancer
https://www.readbyqxmd.com/read/29052905/metabolic-changes-in-patients-with-prostate-cancer-during-androgen-deprivation-therapy
#17
REVIEW
Koji Mitsuzuka, Yoichi Arai
Androgen deprivation therapy continues to be widely used for the treatment of prostate cancer despite the appearance of new-generation androgen-receptor targeting drugs after 2000. Androgen deprivation therapy can alleviate symptoms in patients with metastatic prostate cancer and might have a survival benefit in some patients, but it causes undesirable changes in lipid, glucose, muscle or bone metabolism. These metabolic changes could lead to new onset or worsening of diseases, such as obesity, metabolic syndrome, diabetes mellitus, cardiovascular disease, sarcopenia or fracture...
October 20, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29052761/does-surgical-delay-for-radical-prostatectomy-affect-biochemical-recurrence-a-retrospective-analysis-from-a-canadian-cohort
#18
Marc Zanaty, Mansour Alnazari, Khaled Ajib, Kelsey Lawson, Mounsif Azizi, Emad Rajih, Abdullah Alenizi, Pierre-Alain Hueber, Côme Tolmier, Malek Meskawi, Fred Saad, Raisa S Pompe, Pierre I Karakiewicz, Assaad El-Hakim, Kevin C Zorn
AIM: We sought to explore the impact of surgical wait time (SWT) to robot-assisted radical prostatectomy (RARP) on biochemical recurrence (BCR). METHOD: Retrospective review of a prospectively collected database between 2006 and 2015 was conducted on all RARP cases. SWT was defined as period from prostate biopsy to surgery. Primary outcome was the impact on BCR, which was defined as two consecutive PSA ≥ 0.2 ng/dl, or salvage external beam radiation therapy and/or salvage androgen deprivation therapy...
October 20, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29052664/a-qualitative-study-exploring-models-of-supportive-care-in-men-and-their-partners-caregivers-affected-by-metastatic-prostate-cancer
#19
Charlotte Primeau, Catherine Paterson, Ghulam Nabi
PURPOSE/OBJECTIVES: To explore the experiences of patients with metastatic prostate cancer and their partners/caregivers, as well as an interprofessional team, with a nurse-led multimodality supportive care intervention. 
. RESEARCH APPROACH: Qualitative study. 
. SETTING: National Health Service (NHS), Tayside, Scotland.
. PARTICIPANTS: 19 patients, 7 partners/caregivers, and 7 interprofessional members from four hospitals in NHS, Tayside, Scotland...
November 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/29052565/factors-predicting-late-rectal-disorders-after-radiation-therapy-for-prostate-cancer
#20
Toshiya Maebayashi, Naoya Ishibashi, Takuya Aizawa, Masakuni Sakaguchi, Hideki Sato, Katsuhiko Sato, Tsuyoshi Matsui, Kenya Yamaguchi, Satoru Takahashi
BACKGROUND: Although various studies have been conducted on the effects of radiation therapy for prostate cancer, rectal toxicity after radiation therapy for prostate cancer, which is an important late adverse event associated with radiation therapy, has not been sufficiently examined. This study aimed to assess the associations of late rectal disorder (LRD) with dosimetric, anatomic, and clinical factors in patients with prostate cancer who underwent three-dimensional conformal radiation therapy (3D-CRT)...
October 20, 2017: Chinese Medical Journal
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