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Cytomegalovirus

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https://www.readbyqxmd.com/read/28524216/-update-on-congenital-and-neonatal-herpes-infections-infection-due-to-cytomegalovirus-and-herpes-simplex
#1
F Baquero-Artigao
Newborn infants are a population which is especially susceptible to viral infections that frequently affect the central nervous system. Herpes infections can be transmitted to the foetus and to the newborn infant, and give rise to severe clinical conditions with long-term sensory and cognitive deficits. Two thirds of newborn infants with encephalitis due to herpes simplex virus and half of the children with symptomatic congenital infection by cytomegalovirus develop sequelae, which results in high community health costs in the long term...
May 17, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28523518/decreased-human-leukocyte-antigen-a-02-01-frequency-is-associated-with-risk-of-glioma-and-existence-of-human-cytomegalovirus-a-case-control-study-in-northern-china
#2
Sheng Han, Jian Deng, Zixun Wang, Huan Liu, Wen Cheng, Anhua Wu
BACKGROUND: Human leukocyte antigens (HLAs) play an important role in host defense against viral infection and tumorigenesis. Human cytomegalovirus (HCMV) has been linked to glioma development. This study investigated the relationship between HLA distribution, presence of HCMV, and glioma development in a Han Chinese population. METHODS: The study population included 150 glioma patients and 150 tumor-free brain injury control subjects (control-A) matched according to geography, ethnicity, age, and gender...
May 18, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28523231/association-of-anti-gangliosides-antibodies-and-anti-cmv-antibodies-in-guillain-barr%C3%A3-syndrome
#3
Lijuan Wang, Chunqing Shao, Chunjiao Yang, Xixiong Kang, Guojun Zhang
INTRODUCTION: Numerous types of infection were closely related to GBS, mainly including Campylobacter jejuni, Cytomegalovirus, which may lead to the production of anti-gangliosides antibodies (AGA). Currently, although there are increased studies on the AGA and a few studies of anti-CMV antibodies in GBS, the association between them remains poorly documented. Therefore, our research aims to analyze the correlation of anti-CMV antibodies and AGA in GBS. METHODS: A total of 29 patients with GBS were enrolled in this study...
May 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28522662/apparent-diffusion-coefficient-value-changes-and-clinical-correlation-in-90-cases-of-cytomegalovirus-infected-fetuses-with-unremarkable-fetal-mri-results
#4
D Kotovich, J S B Guedalia, C Hoffmann, G Sze, A Eisenkraft, G Yaniv
BACKGROUND AND PURPOSE: Cytomegalovirus is the leading intrauterine infection. Fetal MR imaging is an accepted tool for fetal brain evaluation, yet it still lacks the ability to accurately predict the extent of the neurodevelopmental impairment, especially in fetal MR imaging scans with unremarkable findings. Our hypothesis was that intrauterine cytomegalovirus infection causes diffusional changes in fetal brains and that those changes may correlate with the severity of neurodevelopmental deficiencies...
May 18, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28521201/validation-of-the-use-of-an-artificial-mitochondrial-reporter-dna-vector-containing-a-cytomegalovirus-promoter-for-mitochondrial-transgene-expression
#5
Yuma Yamada, Takuya Ishikawa, Hideyoshi Harashima
Mitochondria have their own gene expression system that is independent of the nuclear system, and control cellular functions in cooperation with the nucleus. While a number of useful technologies for achieving nuclear transgene expression have been reported, only a few have focused on mitochondria. In this study, we validated the utility of an artificial mitochondrial DNA vector with a virus promoter on mitochondrial transgene expression. We designed and constructed pCMV-mtLuc (CGG) that contains a CMV promotor derived from Cytomegalovirus and an artificial mitochondrial genome with a NanoLuc (Nluc) luciferase gene that records adjustments to the mitochondrial codon system...
May 10, 2017: Biomaterials
https://www.readbyqxmd.com/read/28515602/respiratory-multiplex-polymerase-chain-reaction-an-important-diagnostic-tool-in-immunocompromised-patients
#6
Amarjeet Kaur, Navin Kumar, Sharmila Sengupta, Yatin Mehta
BACKGROUND: Viruses and atypical pathogens can cause significant respiratory illness in immunocompromised patients. Multiplex polymerase chain reaction (MPCR) has improved the diagnostic yield of pathogens, and it is easier to identify the co-infections also. The present study was done to evaluate the performance of MPCR on bronchoalveolar lavage (BAL) samples in immunocompromised patients. METHODS: Atotal of 177 BAL specimens collected over a 19 months period from immunocompromised patients with respiratory illness were analyzed with the MPCR and aerobic culture...
April 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28515356/licensing-delineates-helper-and-effector-nk-cell-subsets-during-viral-infection
#7
Anthony E Zamora, Ethan G Aguilar, Can M Sungur, Lam T Khuat, Cordelia Dunai, G Raymond Lochhead, Juan Du, Claire Pomeroy, Bruce R Blazar, Dan L Longo, Jeffrey M Venstrom, Nicole Baumgarth, William J Murphy
Natural killer (NK) cells can be divided into phenotypic subsets based on expression of receptors that bind self-MHC-I molecules, a concept termed licensing or education. Here we show NK cell subsets with different migratory, effector, and immunoregulatory functions in dendritic cell and antigen (ag)-specific CD8+ T cell responses during influenza and murine cytomegalovirus infections. Shortly after infection, unlicensed NK cells localized in draining lymph nodes and produced GM-CSF, which correlated with the expansion and activation of dendritic cells, and resulted in greater and sustained ag-specific T cell responses...
May 18, 2017: JCI Insight
https://www.readbyqxmd.com/read/28514919/periconceptional-cmv-infection-prevention-in-portugal-population-subgroup-study-in-a-tertiary-perinatal-care-center
#8
Patrícia Sousa, Gabriel Madureira, Marina Moucho, Ana Lídia Sampaio-Dias, Nuno Montenegro
Currently in Portugal, universal screening of pregnant women for Cytomegalovirus (CMV) infection is not performed. However, it is recommended to screen all women attending preconception care. We aimed to assess women's attendance to preconception care and if their serologic status regarding CMV was known and/or investigated in that consultation. In this cross-sectional study, we interviewed 240 women admitted to the obstetrical ward of a hospital in the Metropolitan Area of Porto (Portugal) about their adherence to preconception care and collected data regarding their CMV serologic status and its investigation...
May 17, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28514666/a-temporal-proteomic-map-of-epstein-barr-virus-lytic-replication-in-b-cells
#9
Ina Ersing, Luis Nobre, Liang Wei Wang, Lior Soday, Yijie Ma, Joao A Paulo, Yohei Narita, Camille W Ashbaugh, Chang Jiang, Nicholas E Grayson, Elliott Kieff, Steven P Gygi, Michael P Weekes, Benjamin E Gewurz
Epstein-Barr virus (EBV) replication contributes to multiple human diseases, including infectious mononucleosis, nasopharyngeal carcinoma, B cell lymphomas, and oral hairy leukoplakia. We performed systematic quantitative analyses of temporal changes in host and EBV proteins during lytic replication to gain insights into virus-host interactions, using conditional Burkitt lymphoma models of type I and II EBV infection. We quantified profiles of >8,000 cellular and 69 EBV proteins, including >500 plasma membrane proteins, providing temporal views of the lytic B cell proteome and EBV virome...
May 16, 2017: Cell Reports
https://www.readbyqxmd.com/read/28513970/cytomegalovirus-infection-and-atherosclerosis-risk-a-meta-analysis
#10
Yang-Jie Jia, Jun Liu, Fei-Fei Han, Zi-Rui Wan, Li-Li Gong, He Liu, Wen Zhang, Thomas Wardell, Ya-Li Lv, Li-Hong Liu
BACKGROUND: Human cytomegalovirus (HCMV) infection is an important risk factor for atherosclerosis (AS). Numerous studies have been conducted to analyze the association between HCMV infection and risk of AS, but no clear consensus has been reached. So the objective of this paper was aimed to demonstrate the relationship between HCMV and AS by doing a meta-analysis. METHODS: Relative literature was searched through the electronic databases PubMed, Embase, and CNKI...
May 17, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28509677/stool-cytomegalovirus-polymerase-chain-reaction-for-the-diagnosis-of-cytomegalovirus-related-gastrointestinal-disease
#11
Noparat Prachasitthisak, Pornthep Tanpowpong, Chatmanee Lertudomphonwanit, Suporn Treepongkaruna, Sophida Boonsathorn, Napat Angkathunyakul, Pattana Sornmayura, Wasun Chantratita
OBJECTIVES: The diagnosis of cytomegalovirus-related gastrointestinal disease (CMV-GI disease) still requires histopathology, but biopsy is considered invasive. Stool CMV PCR has been reported in adults as an alternative method to diagnose this condition; hence, the results between studies are discrepant. Moreover, no pediatric studies on stool CMV real-time PCR in CMV-GI disease have been carried out. Here, we evaluate the value of stool CMV real-time PCR in detecting CMV-GI disease among immunocompromised children...
May 15, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28508343/cytomegalovirus-infection-in-pregnancy
#12
REVIEW
Karl Oliver Kagan, Klaus Hamprecht
PURPOSE: Due to the severe risk of long-term sequelae, prenatal cytomegalovirus infection is of particular importance amongst intrauterine viral infections. This review summarizes the current knowledge about CMV infection in pregnancy. METHODS: A search of the Medline and Embase database was done for articles about CMV infection in pregnany. We performed a detailed review of the literature in view of diagnosis, epidemiology and management of CMV infection in pregnancy...
May 15, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28508224/rescue-of-infectious-salmon-anemia-virus-isav-from-cloned-cdna
#13
Daniela Toro-Ascuy, Marcelo Cortez-San Martín
The piscine Orthomyxovirus called Infectious Salmon Anemia Virus (ISAV) is one of the most important emerging pathogens affecting the salmon industry worldwide. The first reverse genetics system for ISAV, which allows the generation of recombinant ISA virus (rISAV), is an important tool for the characterization and study of this fish virus. The plasmid-based reverse genetics system for ISAV includes the use of a novel fish promoter, the Atlantic salmon internal transcribed spacer region 1 (ITS-1). The salmon, viral and mammalian genetic elements included in pSS-URG vectors allow the expression of the eight viral RNA segments...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28507767/post-traumatic-stress-in-pregnant-women-with-primary-cytomegalovirus-infection-and-risk-of-congenital-infection-in-newborns
#14
Francesco Vadini, Elisa Tracanna, Ennio Polilli, Monica Tontodonati, Elena Ricci, Francesca Santilli, Giustino Parruti
BACKGROUND: Substantial evidence indicates that perinatal mental disturbances are associated with the risk for negative maternal-newborn outcomes. A neuroendocrine brain-placenta interaction has been described to explain the association between prenatal stress-related disorders and placental abnormalities. Whether these mechanisms may affect the likelihood of mother-to-child transmission (MTCT) of infections has never been investigated. AIMS: To evaluate the role of psychological factors in cytomegalovirus (CMV) MTCT in pregnant women with primary CMV infection...
November 2016: BJPsych Open
https://www.readbyqxmd.com/read/28506786/diagnostic-test-accuracy-of-antigenemia-assay-for-polymerase-chain-reaction-proven-cytomegalovirus-infection-systematic-review-and-meta-analysis
#15
REVIEW
Hisashi Eguchi, Nobuyuki Horita, Ryota Ushio, Ikuma Kato, Yuki Nakajima, Erika Ota, Takeshi Kaneko
OBJECTIVES: We aimed to assess diagnostic test accuracy of antigenemia assay for PCR proven cytomegalovirus (CMV) infection. METHODS: We systematically searched studies that provide data both on sensitivity and specificity of the CMV antigenemia assay using the PCR as the reference standard. Adults, children, infants, subjects who were immunocompromised for any reason, symptomatic patients, and asymptomatic individuals were all included. Hierarchical summary receiver operating characteristics model was used for diagnostic meta-analysis...
May 12, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28506343/-current-status-of-research-on-infantile-cholestatic-liver-disease-in-china-a-visualization-analysis
#16
Qiong Liao, Chao-Min Wan, Yu Zhu, Xiao-Yan Yang, Min Shu
OBJECTIVE: To investigate the current status of research on infantile cholestatic liver disease in China and future research trends. METHODS: A co-word analysis was performed in October 2016. Document retrieval and screening were performed in the Chinese databases CNKI and Wanfang Data using "cholestasis" and "infant" as key words. Excel 2010 was used to establish a co-occurrence matrix of high-frequency key words, and Ucinet 6.0 and Netdraw were used to develop a visualized network of these high-frequency key words...
May 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28505965/determining-the-igm-and-igg-antibody-titer-against-cmv-and-helicobacter-pylori-in-the-serum-of-multiple-sclerosis-patients-comparing-to-the-control-group-in-hamadan
#17
Masome Afiati Salim, Mohammad Mahdi Eftekharian, Mohammad Taheri, Mohammad Yousef Alikhani
BACKGROUND: Multiple sclerosis (MS) is a chronic autoimmune disease that disables Central nervous system (CNS) system. Cytomegalovirus (CMV) probably has an important role in the MS pathology. The infection with helicobacter pylori also is recognized as a protective agent against MS in female. METHODS: Serum samples were isolated and frozen at -70°C. The earlier mentioned anti-virus antibodies and antibacterial antibodies were quantified by Elisa kit. RESULTS: The results showed that IgG antibody average value against cytomegalovirus in the blood of multiple sclerosis patients not only decreased but also was significant statistically (p< 0...
May 5, 2017: Human Antibodies
https://www.readbyqxmd.com/read/28505602/unusual-antigen-presentation-offers-new-insight-into-hiv-vaccine-design
#18
REVIEW
Andrew J McMichael, Louis J Picker
Recent findings with a rhesus monkey cytomegalovirus based simian immunodeficiency virus vaccine have identified strong CD8+ T cell responses that are restricted by MHC-E. Also mycobacteria specific CD8+ T cells, that are MHC-E restricted, have been identified. MHC-E therefore can present a wide range of epitope peptides to CD8+ T cells, alongside its well defined role in presenting a conserved MHC-class I signal peptide to the NKG2A/C-CD94 receptor on natural killer cells. Here we explore the antigen processing pathways involved in these atypical T cell responses...
May 12, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28505028/cytomegalovirus-disease-in-hematopoietic-stem-cell-transplant-patients-current-and-future-therapeutic-options
#19
Shigeo Fuji, Hermann Einsele, Markus Kapp
PURPOSE OF REVIEW: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has become one of the standard treatment for hematological diseases. Although the clinical outcome has improved significantly during the last decades, the morbidity and mortality after allo-HSCT are still obstacles to cure. Out of major morbidities, opportunistic virus infections such as cytomegalovirus (CMV) infection are important complications, in particular in patients who received human leukocyte antigen-mismatched HSCT...
May 12, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28503279/incidence-and-risk-factors-for-cytomegalovirus-in-kidney-transplant-patients-in-babol-northern-iran
#20
Arefeh Babazadeh, Mostafa Javanian, Farshid Oliaei, Roghayeh Akbari, Abazar Akbarzadepasha, Ali Bijani, Mahmoud Sadeghi
BACKGROUND: Cytomegalovirus (CMV) disease is an important cause of death and possibly transplant rejection in kidney transplant (KT) patients. This study was conducted to investigate the incidence and risk factors of CMV disease in kidney transplant patients. METHODS: All end-stage renal disease (ESRD) patients who underwent kidney transplantation during 1998-2014 and their donors were assessed. All samples were followed-up for approximately 70 months. CMV was identified by polymerase chain reaction (PCR) and/or PP65 antigen in peripheral blood leukocytes along with clinical manifestations...
2017: Caspian Journal of Internal Medicine
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