Romualdo Sciorio, Gerard Campos, Luca Tramontano, Francesco M Bulletti, Giorgio M Baldini, Marina Vinciguerra
Since the birth of the first baby by in vitro fertilization in 1978, more than 9 million children have been born worldwide using medically assisted reproductive treatments. Fertilization naturally takes place in the maternal oviduct where unique physiological conditions enable the early healthy development of the embryo. During this dynamic period of early development major waves of epigenetic reprogramming, crucial for the normal fate of the embryo, take place. Increasingly, over the past 20 years concerns relating to the increased incidence of epigenetic anomalies in general, and genomic-imprinting disorders in particular, have been raised following assisted reproduction technology (ART) treatments...
July 6, 2023: Zygote: the Biology of Gametes and Early Embryos