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https://www.readbyqxmd.com/read/29344793/the-role-of-bone-secreted-factors-in-burn-induced-muscle-cachexia
#1
REVIEW
Gordon L Klein
PURPOSE OF REVIEW: Burn injury results in resorptive bone loss, failure to make new bone, and muscle protein breakdown resulting in cachexia. The purpose of this review is to examine the relationship between bone loss and muscle atrophy in burn injury with a view to understanding the process at work and how it may apply to other conditions that have similar features. RECENT FINDINGS: We present data suggesting that the use of bisphosphonates in the first 10 days following the burn prevents not only the resorptive bone loss but also the muscle wasting...
January 17, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29343989/comparison-of-the-performance-of-five-screening-methods-for-sarcopenia
#2
Médéa Locquet, Charlotte Beaudart, Jean-Yves Reginster, Jean Petermans, Olivier Bruyère
Background: Sarcopenia leads to serious adverse health consequences. There is a dearth of screening tools for this condition, and performances of these instruments have rarely been evaluated. Our aim was to compare the performance of five screening tools for identifying elders at risk of sarcopenia against five diagnostic definitions. Subjects and methods: We gathered cross-sectional data of elders from the SarcoPhAge ("Sarco"penia and "Ph"ysical Impairment with Advancing "Age") study...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29340001/neuromuscular-control-during-the-bench-press-movement-in-an-elite-disabled-and-able-bodied-athlete
#3
Artur Gołaś, Anna Zwierzchowska, Adam Maszczyk, Michał Wilk, Petr Stastny, Adam Zając
The disabled population varies significantly in regard to physical fitness, what is conditioned by the damage to the locomotor system. Recently there has been an increased emphasis on the role of competitive sport in enhancing health and the quality of life of individuals with disability. One of the sport disciplines of Paralympics is the flat bench press. The bench press is one of the most popular resistance exercises used for the upper body in healthy individuals. It is used not only by powerlifters, but also by athletes in most strength-speed oriented sport disciplines...
December 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29336645/physical-exercise-prior-to-hematopoietic-stem-cell-transplantation-a-feasibility-study
#4
Inge E P M van Haren, J Bart Staal, Carin M Potting, Femke Atsma, Thomas J Hoogeboom, Nicole M A Blijlevens, Maria W G Nijhuis-van der Sanden
PURPOSE: This study explores the feasibility and preliminary effectiveness of an exercise program in people scheduled for hematopoietic stem cell transplantation (HSCT). METHODS: In this controlled clinical trial, we compare pre-transplantation exercise to no exercise in the waiting period for an allogeneic of autologous HSCT. The supervised individually tailored exercise program (4-6 weeks) consisted of aerobic endurance, muscle strength, and relaxation exercises, administered twice a week in the period prior to HSCT...
January 16, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29333278/clinical-influence-of-exercise-therapy-on-sarcopenia-in-patients-with-chronic-pancreatitis-a-study-protocol-for-a-randomised-controlled-trial
#5
Kazunori Yoh, Hiroki Nishikawa, Hirayuki Enomoto, Yoshinori Iwata, Akio Ishii, Yukihisa Yuri, Noriko Ishii, Yuho Miyamoto, Kunihiro Hasegawa, Chikage Nakano, Ryo Takata, Takashi Nishimura, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Hiroko Iijima, Shuhei Nishiguchi
Introduction and purpose: Chronic pancreatitis (CP) involves progressive inflammatory changes to the pancreas and can lead to permanent structural damage and impairment of both endocrine and exocrine functions. Current reports highlight a rise in the incidence and prevalence of CP. However, there is limited data currently available concerning patients with CP undergoing exercise therapy (ET). We aim to prospectively examine the influence of ET on sarcopenia in patients with CP. Methods and analysis: A detailed evaluation of the nutritional condition and the daily physical activities of each participant will be conducted prior to entering the study...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29331536/chronic-inflammation-and-sarcopenia-a-regenerative-cell-therapy-perspective
#6
Jagadish K Chhetri, Philipe de Souto Barreto, Bertrand Fougère, Yves Rolland, Bruno Vellas, Matteo Cesari
Sarcopenia is characterized by reduced skeletal muscle mass and strength in older individuals. It is one of the leading cause of physical limitation in older adults, and associated with wide spectrum of adverse events including disability and mortality. The phenomenon of chronic-inflammation or inflamm-aging with aging is known to be a major contributor to myriad of geriatric conditions including sarcopenia. Recent advances in regenerative medicine, in particular cell therapy have opened up new possibilities to ameliorate broad range of inflammatory disorders...
January 10, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29329154/effects-on-volume-load-and-ratings-of-perceived-exertion-in-individuals-advanced-weight-training-after-transcranial-direct-current-stimulation
#7
Eduardo Lattari, Blair José Rosa Filho, Sidnei Jorge Fonseca Junior, Eric Murillo-Rodriguez, Nuno Rocha, Sérgio Machado, Geraldo Albuquerque Maranhão Neto
The aim of this study was investigate the effects of transcranial direct current stimulation (tDCS) on volume-load and ratings of perceived exertion. Fifteen young healthy individuals, aged between 20 and 30 years in advanced strength training were recruited. Test and retest of the 10 maximum repetitions (10RM) were performed to determine the reliability of load utilized. Subjects performed three experimental conditions in a randomized, double-blinded crossover design: anodic stimulation (a-tDCS), cathodic stimulation (c-tDCS) and sham (2 mA for 20 minutes targeting the dorsolateral prefrontal cortex cortex left)...
January 11, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29327605/does-change-in-isolated-lumbar-extensor-muscle-function-correlate-with-good-clinical-outcome-a-secondary-analysis-of-data-on-change-in-isolated-lumbar-extension-strength-pain-and-disability-in-chronic-low-back-pain
#8
James Steele, James Fisher, Craig Perrin, Rebecca Conway, Stewart Bruce-Low, Dave Smith
PURPOSE: Secondary analysis of data from studies utilising isolated lumbar extension exercise interventions for correlations among changes in isolated lumbar extension strength, pain, and disability. MATERIALS AND METHODS: Studies reporting isolated lumbar extension strength changes were examined for inclusion criteria including: (1) participants with chronic low back pain, (2) intervention ≥ four weeks including isolated lumbar extension exercise, (3) outcome measures including isolated lumbar extension strength, pain (Visual Analogue Scale), and disability (Oswestry Disability Index)...
January 12, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29321467/importance-of-regular-and-maintenance-therapy-adherence-in-neuromyelitis-optica-nmo-lessons-from-a-repeating-relapse-case
#9
Jing Miao, Doreen E Aboagye, Boris Chulpayev, Lin Liu, Gary Ishkanian, Bangaruraju Kolanuvada, Dariush Alaie, Richard L Petrillo
BACKGROUND Neuromyelitis optica (NMO) is a rare demyelinating disease of the central nervous system; NMO predominantly affects the spinal cord and optic nerves. The diagnosis is based on history, clinical presentation, seropositive NMO-IgG antibody, and notably, exclusion of other diseases. Despite the absence of definitive therapeutic strategies for NMO, methylprednisolone pulse therapy and plasma exchange are used for acute phase treatment, while immunosuppressive agent(s) are recommended to prevent relapses and improve prognosis...
January 11, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29321341/exercise-tolerance-and-balance-of-inspiratory-to-expiratory-muscle-strength-in-relation-to-breathing-timing-in-patients-with-chronic-obstructive-pulmonary-disease
#10
Keisuke Miki, Kazuyuki Tsujino, Tatsuya Edahiro, Seigo Kitada, Mari Miki, Kenji Yoshimura, Hiroyuki Kagawa, Yohei Oshitani, Yuko Ohara, Yuki Hosono, Hiroyuki Kurebe, Ryoji Maekura
Little is known about the applicability of respiratory muscle training based on exertional pathophysiological conditions in patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the relationship between breathing timing and exertional responses, as well as whether exertional changes in the inspiratory duty cycle (inspiratory time [Ti]/total time [Ttot]) affect pathophysiological conditions, including respiratory muscles. Methods: Forty-five stable COPD patients (mean age: 71...
January 11, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29284912/lower-jaw-grip-strength-in-healthy-and-sick-population-measured-by-special-force-transducer
#11
Dino Dizdarevic, Tarik Masic, Edi Muslic
Introduction: One of the basic chronic diseases of the MFH domain that is treated on an outpatient basis is temporomandibular dysfunction (TMD). It represents a number of pathological conditions that lead to the dysfunction of the normal function of the stomatognatic system. Observing the etiologic factors of this condition, temporomandibular TM trauma, poor habits such as infantile type of swallowing, tongue depression, and tectogenic disturbance of the myofunctional squamous system are reported in order to reconstruct the defects of neighboring regions...
December 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/29284521/exercise-intervention-for-unilateral-amputees-with-low-back-pain-study-protocol-for-a-randomised-controlled-trial
#12
Joseph G Wasser, Daniel C Herman, MaryBeth Horodyski, Jason L Zaremski, Brady Tripp, Phillip Page, Kevin R Vincent, Heather K Vincent
BACKGROUND: Atraumatic lower limb amputation is a life-changing event for approximately 185,000 persons in the United States each year. A unilateral amputation is associated with rapid changes to the musculoskeletal system including leg and back muscle atrophy, strength loss, gait asymmetries, differential mechanical joint loading and leg length discrepancies. Even with high-quality medical care and prostheses, amputees still develop secondary musculoskeletal conditions such as chronic low back pain (LBP)...
December 29, 2017: Trials
https://www.readbyqxmd.com/read/29283292/morphological-molecular-and-hormonal-adaptations-to-early-morning-versus-afternoon-resistance-training
#13
Milan Sedliak, Michal Zeman, Gabriel Buzgó, Jan Cvecka, Dusan Hamar, Eugen Laczo, Monika Okuliarova, Marian Vanderka, Tomas Kampmiller, Keijo Häkkinen, Juha P Ahtiainen, Juha J Hulmi, Tormod S Nilsen, Håvard Wiig, Truls Raastad
It has been clearly established that maximal force and power is lower in the morning compared to noon or afternoon hours. This morning neuromuscular deficit can be diminished by regularly training in the morning hours. However, there is limited and contradictory information upon hypertrophic adaptations to time-of-day-specific resistance training. Moreover, no cellular or molecular mechanisms related to muscle hypertrophy adaptation have been studied with this respect. Therefore, the present study examined effects of the time-of-day-specific resistance training on muscle hypertrophy, phosphorylation of selected proteins, hormonal concentrations and neuromuscular performance...
December 28, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29282529/the-development-of-skeletal-muscle-hypertrophy-through-resistance-training-the-role-of-muscle-damage-and-muscle-protein-synthesis
#14
REVIEW
Felipe Damas, Cleiton A Libardi, Carlos Ugrinowitsch
Resistance training (RT)-induced skeletal muscle hypertrophy is a highly intricate process. Despite substantial advances, we are far from understanding exactly how muscle hypertrophy develops during RT. The aim of the present review is to discuss new insights related to the role of skeletal muscle damage and muscle protein synthesis (MPS) in mediating RT-induced hypertrophy. Specifically, the thesis that in the early phase of RT (≤ 4 previous RT sessions) increases in muscle cross-sectional area are mostly attributable to muscle damage-induced muscle swelling; then (after ~ 10 sessions), a modest magnitude of muscle hypertrophy ensues; but only during a latter phase of RT (after ~ 18 sessions) is true muscle hypertrophy observed...
December 27, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29275614/-wound-repair-and-functional-reconstruction-of-high-voltage-electrical-burns-in-wrists
#15
Y M Shen, C X Ma, F J Qin, C Zhang, C Wang, X H Hu
Objective: To explore the methods and effects of wound repair and functional reconstruction of high-voltage electrical burns in wrists. Methods: From January 2009 to June 2016, 71 patients with high-voltage electrical burns in wrists were hospitalized, with 118 wrist wounds including 21 of type Ⅰ, 69 of type Ⅱ, 9 of type Ⅲ, and 19 of type Ⅳ. According to the wrist injuries, different surgical operations were performed. Forearm amputation was conducted in 20 wrists with necrosis in the distal end. On the basis of fasciotomy for decompression, early debridement was performed on the other 98 wrist wounds...
December 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29273081/sex-specific-phenotypes-of-hyperthyroidism-and-hypothyroidism-in-aged-mice
#16
Helena Rakov, Kathrin Engels, Georg Sebastian Hönes, Klaudia Brix, Josef Köhrle, Lars Christian Moeller, Denise Zwanziger, Dagmar Führer
BACKGROUND: Sex and age play a role in the prevalence of thyroid dysfunction (TD), but their interrelationship for manifestation of hyper- and hypothyroidism is still not well understood. Using a murine model, we asked whether sex impacts the phenotypes of hyper- and hypothyroidism at two life stages. METHODS: Hyper- and hypothyroidism were induced by i.p. T4 or MMI/ClO4-/LoI treatment over 7 weeks in 12- and 20-months-old female and male C57BL/6N mice. Control animals underwent PBS treatment (n = 7-11 animals/sex/treatment)...
December 22, 2017: Biology of Sex Differences
https://www.readbyqxmd.com/read/29258769/calcium-and-vitamin-d-in-human-health-hype-or-real
#17
REVIEW
Sunil J Wimalawansa, DSc Mohammed S Razzaque, Nasser M Al-Daghri
The incidence and the prevalence of vitamin D deficiency are increasing worldwide. It is estimated that over 50% of population in the world have low in vitamin D (i.e., hypovitaminosis D; levels below 30 ng/mL). 80% of our vitamin D requirement comes from the ultraviolet rays from sunlight, and for the remainder, we rely from the diet and supplements. The latter become important when one is exposing to less than optimal amounts of sunlight, inability of the skin to generate vitamin D efficiently, and/or having secondary causes that leads to increase catabolism of vitamin D...
December 16, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29258243/canadine-from-corydalis-turtschaninovii-stimulates-myoblast-differentiation-and-protects-against-myotube-atrophy
#18
Heyjin Lee, Sang-Jin Lee, Gyu-Un Bae, Nam-In Baek, Jae-Ha Ryu
Cachexia and sarcopenia are the main causes of muscle atrophy. These result in a reduction in the muscle fiber area, myo-protein content, and muscle strength, with various molecular modulators being involved. Although several reports have proposed potential therapeutic agents, no effective treatments have been found for muscle atrophy. We searched for myogenic modulators from medicinal plants to treat muscle diseases. We isolated six alkaloids from Corydalis turtschaninovii and evaluated their myogenic potential by using the MyoD reporter gene assay in C2C12 cells...
December 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29249454/biomechanical-consequences-of-running-with-deep-core-muscle-weakness
#19
Margaret E Raabe, Ajit M W Chaudhari
The deep core muscles are often neglected or improperly trained in athletes. Improper function of this musculature may lead to abnormal spinal loading, muscle strain, or injury to spinal structures, all of which have been associated with increased low back pain (LBP) risk. The purpose of this study was to identify potential strategies used to compensate for weakness of the deep core musculature during running and to identify accompanying changes in compressive and shear spinal loads. Kinematically-driven simulations of overground running were created for eight healthy young adults in OpenSim at increasing levels of deep core muscle weakness...
December 6, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29248172/the-effects-of-forward-head-posture-on-neck-extensor-muscle-thickness-an-ultrasonographic-study
#20
Fereshte Goodarzi, Leila Rahnama, Noureddin Karimi, Raziyeh Baghi, Shapour Jaberzadeh
OBJECTIVE: This study aimed to compare neck extensor muscle thickness, thickness changes, and strength between participants with forward head posture (FHP) and controls with normal head posture (NHP). METHODS: Twenty college students with FHP (mean age 21.30 ± 2.36 years) and 20 students with NHP (mean age 21.85 ± 2.78 years) participated in this case-control study. The thickness of neck extensor muscles was measured at rest and at maximal voluntary isometric contraction (MVIC)...
December 13, 2017: Journal of Manipulative and Physiological Therapeutics
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