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JOURNAL ARTICLE
Anders Wanhainen, Isabelle Van Herzeele, Frederico Bastos Goncalves, Sergi Bellmunt Montoya, Xavier Berard, Jonathan R Boyle, Mario D'Oria, Carlota F Prendes, Christos D Karkos, Arkadiusz Kazimierczak, Mark J W Koelemay, Tilo Kölbel, Kevin Mani, Germano Melissano, Janet T Powell, Santi Trimarchi, Nikolaos Tsilimparis, George A Antoniou, Martin Björck, Raphael Coscas, Nuno V Dias, Philippe Kolh, Sandro Lepidi, Barend M E Mees, Timothy A Resch, Jean Baptiste Ricco, Riikka Tulamo, Christopher P Twine, Daniela Branzan, Stephen W K Cheng, Ronald L Dalman, Florian Dick, Jonathan Golledge, Stephan Haulon, Joost A van Herwaarden, Nikola S Ilic, Arkadiusz Jawien, Tara M Mastracci, Gustavo S Oderich, Fabio Verzini, Kak Khee Yeung
OBJECTIVE: The European Society for Vascular Surgery (ESVS) has developed clinical practice guidelines for the care of patients with aneurysms of the abdominal aorta and iliac arteries in succession to the 2011 and 2019 versions, with the aim of assisting physicians and patients in selecting the best management strategy. METHODS: The guideline is based on scientific evidence completed with expert opinion on the matter. By summarising and evaluating the best available evidence, recommendations for the evaluation and treatment of patients have been formulated...
February 2024: European Journal of Vascular and Endovascular Surgery
#22
Jae Hyun Park, Hye Young Woo, Seung-Kee Min
Aortic pseudoaneurysms (PA) vary in size and may remain asymptomatic. PAs may be caused by vascular injury, such as trauma or surgery, or other non-traumatic causes, such as Bechet disease, infection, or penetrating atherosclerotic ulcers. The diagnosis of PAs may have been delayed for decades. We present a case of a PA detected incidentally in a male patient who experienced traumatic bowel perforation due to blunt abdominal trauma 30 years before presentation. Computed tomography (CT) displayed a 9.2 cm mass in the pelvis, initially considered a neoplasm of small bowel origin...
February 2, 2024: Vascular Specialist International
#23
JOURNAL ARTICLE
Tom M Withers, Colin J Greaves, Matt J Bown, Athanasios Saratzis
BACKGROUND: Abdominal aortic aneurysm (AAA) is an important cardiovascular health problem. Ultrasound screening is proven to reduce AAA mortality and programmes have been implemented in some healthcare systems. Those who are identified as having a small AAA in screening enter into a surveillance programme to monitor AAA size. Individuals in AAA surveillance are at elevated risk of cardiovascular events, which is not currently addressed sufficiently. We aimed to develop a simple intervention to reduce cardiovascular risk, which could be embedded in AAA surveillance pathways...
January 29, 2024: Pilot and Feasibility Studies
#24
JOURNAL ARTICLE
Georgios Sachsamanis, Julio Perez Delgado, Kyriakos Oikonomou, Wilma Schierling, Karin Pfister, Carl Zuelke, Thomas Betz
BACKGROUND: Prophylactic mesh implantation following open surgical repair of abdominal aortic aneurysm is a debatable subject. OBJECTIVE: To assess the efficacy of a self-gripping polyester mesh used in on-lay technique to prevent incisional hernia after open abdominal aortic aneurysm repair. METHODS: We retrospectively reviewed the records of 495 patients who underwent aortic surgery between May 2017 and May 2021. Patients included in the study underwent open surgical repair for infrarenal abdominal aortic aneurysm (AAA) with closure of the abdominal wall with either small bite suture technique or prophylactic mesh reinforcement...
January 20, 2024: Clinical Hemorheology and Microcirculation
#25
JOURNAL ARTICLE
Anne Lise Meulenbroek, Ewout W Steyerberg, Ties L Janssen, Stefanie R van Mil, Miriam C Faes, Lijckle van der Laan
OBJECTIVE: Delirium is a common and serious postoperative complication in elderly patients undergoing abdominal aortic aneurysm (AAA) repair and is associated with a variety of adverse outcomes. Multimodal prehabilitation aims to identify and minimize potential risk factors for delirium and improve overall health. The aim of this study is to investigate the effect of multimodal prehabilitation on delirium incidence in elderly patients undergoing elective repair for AAA. METHODS: A single-centre cohort analysis was performed in the Netherlands for patients aged ≥70 years, undergoing elective repair for AAA (open surgery and endovascular aortic repair)...
2024: Clinical Interventions in Aging
#26
Zhen He, Yu Chen, Hongjie Wang, Lei Dai, Hesong Zeng
BACKGROUND: Abdominal aortic aneurysm (AAA) is a segmental, progressive, and fatal vascular disorder, and the current strategy for small AAAs is close observation alone.The purpose of this study is to summarize the available evidence to assess the effects of antibiotics on small abdominal aortic aneurysms (AAA). METHODS: We searched PubMed, EMBASE, Web of Science, and Scopus from inception to September 29, 2023, and included randomized controlled trials (RCTs) that evaluated the effects of antibiotics on small AAAs in humans...
January 9, 2024: Current Medicinal Chemistry
#27
REVIEW
George Kouvelos, George Volakakis, Konstantinos Dakis, Konstantinos Spanos, Athanasios Giannoukas
There has been a debate about whether maximum diameter can be solely used to assess the natural history of abdominal aortic aneurysm. The aim of the present review is to collect all the available evidence on the role of abdominal aortic aneurysm (AAA) volume in the natural history of AAAs, including small untreated AAAs and AAAs treated by EVAR. The current literature appears to reinforce the role of volume as a supplementary measure for evaluating the natural history of AAA, in both intact AAAs and after EVAR...
December 29, 2023: Journal of Clinical Medicine
#28
JOURNAL ARTICLE
Rahul Shetty, Roberto Noland, Ghata Nandi, Carolyn K Suzuki
INTRODUCTION: Mitochondrial LonP1 is an ATP-powered protease that also functions as an ATP-dependent chaperone. LonP1 plays a pivotal role in regulating mitochondrial proteostasis, metabolism and cell stress responses. Cancer cells exploit the functions of LonP1 to combat oncogenic stressors such as hypoxia, proteotoxicity, and oxidative stress, and to reprogram energy metabolism enabling cancer cell proliferation, chemoresistance, and metastasis. AREAS COVERED: LonP1 has emerged as a potential target for anti-cancer therapeutics...
December 29, 2023: Expert Opinion on Therapeutic Targets
#29
JOURNAL ARTICLE
Alexander Oberhuber, Gioele Simonte, Giacomo Isernia, Johannes Schäfers
PURPOSE: To describe the semibranch as new tool to treat patients with thoracoabdominal, para- and juxtarenal aortic pathologies. TECHNIQUE: The technique is demonstrated in 2 patients with aortic pathologies. First, a 76-year-old woman with a type Ia endoleak after endovascular repair of abdominal aneurysm (EVAR). Due to the short mainbody of the EVAR and suprarenal extension of the pathology, a 4-branched device with integrated bifurcation was chosen. To realize a branched device in small diameters of the suprarenal aorta, 2 semibranches, for the superior mesenteric artery (SMA) and the celiac trunc (CT), were planned...
December 22, 2023: Journal of Endovascular Therapy
#30
JOURNAL ARTICLE
Bin Li, Jiexing Huang, Junjie Ruan, Qinghe Peng, Sijuan Huang, Yunfei Li, Fanghua Li
BACKGROUND: Metal artifacts due to spinal implants may affect the accuracy of dose calculation for radiotherapy. However, the dosimetric impact of metal artifact reduction (MAR) for spinal implants in stereotactic body radiotherapy (SBRT) plans has not been well studied. The objective of this study was to evaluate the dosimetric impact of MAR in spinal SBRT planning with three clinically common dose calculation algorithms. METHODS: Gammex phantom and 10 patients' computed tomography (CT) images were studied to investigate the effects of titanium implants...
December 1, 2023: Quantitative Imaging in Medicine and Surgery
#31
REVIEW
Sheyda Khalilian, Mohammad Amin Khazeei Tabari, Mohammad Amin Omrani, Soudeh Ghafouri-Fard
Circular RNAs (circRNAs) are a group of non-coding transcripts in which a loop structure is shaped via a back splicing procedure. They have central roles in the regulation of gene expression. hsa_circ_0008285, alternatively named as circCDYL, is a circular RNA originated from the exon 4 of CDYL gene. It is produced by a back-splice incident and is mainly located in the cytoplasm. It has no internal ribosome entry site, open reading frame and intronic sequences. CircCDYL dysregulation has been reported in the malignant conditions including multiple myeloma, mantle cell lymphoma, breast cancer, non-small cell lung cancer, Wilms tumor, bladder cancer, colon cancer, and hepatocellular carcinoma...
December 12, 2023: Molecular Biology Reports
#32
JOURNAL ARTICLE
circ-ATAD1 as Competing Endogenous RNA for miR-191-5p Forces Non-small Cell Lung Cancer Progression.
Zhihua Wan, Shanshan Jia, Junhua Lu, Xiangjing Ge, Qinghua Chen
The association of circular RNAs (circRNAs) with non-small cell lung cancer (NSCLC) has been recognized extensively. In view of this, our study particularly surveyed the underlying mechanism of circ-ATAD1 in the disease. First, an analysis of the clinical expression of circ-ATPase family AAA domain containing 1 (ATAD1) was performed, followed by further evaluation of the relationship between circ-ATAD1 expression and prognosis. Then, A549 cells were treated with single transfection or combined transfection with the plasmid vectors that interfere with circ-ATAD1 or miR-191-5p...
December 11, 2023: Applied Biochemistry and Biotechnology
#33
JOURNAL ARTICLE
Xiaoyang Fu, Ji Yuan
OBJECTIVE: Abdominal aortic aneurysms (AAA) involving branches of the visceral arteries mainly refer to AAA with flat renal artery (neck length ≤5 mm) or beyond the renal artery, and the branch of the visceral arteries needs to be reconstructed during treatment. Endoluminal repair (EVR) surgery refers to the isolation of AAA with less surgical trauma through vascular puncture, guidewire, catheter, stent and double suturer technology. However, postoperative endoleak is a complication specific to open surgery...
December 2023: Heliyon
#34
JOURNAL ARTICLE
Dongdong Jia, Kangjie Wang, Lin Huang, Zhihao Zhou, Yinfeng Zhang, Nuo Chen, Qingqi Yang, Zengjin Wen, Hui Jiang, Chen Yao, Ridong Wu
BACKGROUND: Abdominal aortic aneurysm (AAA) is a permanent dilation of the abdominal aorta, with a high mortality rate when rupturing. Although lots of piRNA pathway genes (piRPGs) have recently been linked to both neoplastic and non-neoplastic illnesses, their role in AAA is still unknown. Utilizing integrative bioinformatics methods, this research discovered piRPGs as biomarkers for AAA and explore possible molecular mechanisms. METHODS: The datasets were obtained from the Gene Expression Omnibus and piRPGs were identified from the Genecards database...
December 7, 2023: Gene
#35
JOURNAL ARTICLE
Colin Cleary, Ya-Huei Li, Akhilesh Jain, Pranjali Kainkaryam, Parth Shah, Thomas Divinagracia, James Gallagher, Elizabeth Aitcheson, Mouhanad Ayach, Kevin Finkel, Owen Glotzer, Edward Gifford
BACKGROUND: Postoperative pain management remains a barrier to recovery following aortic surgery. Although epidural catheters help in adjunctive pain management, less is known about the use of rectus sheath blocks. We compared patient recovery following open abdominal aortic surgery (OAS) with and without adjunctive rectus block. METHODS: Adult patients undergoing open abdominal aortic aneurysm repair and aortobifemoral or aortoiliac bypass for occlusive disease were identified and stratified by use of general anesthesia alone (GA) versus adjunctive use of a rectus sheath block (GA + RB)...
November 2023: Annals of Vascular Surgery
#36
JOURNAL ARTICLE
Tao Jiang, Ning Li, Hao Xu, Li Sun, Ying Zhang, Qian Luo, Li Yang
Malignant proliferation and abundant angiogenesis are major causes of lung adenocarcinoma (LUAD) with high morbidity and mortality. Therefore, the exploration of the key regulatory mechanisms of malignant proliferation and angiogenesis in LUAD provides an opportunity for the development of targeted precision therapy. In this study, we found that the high expression of ATPase family AAA domain-containing protein 3A (ATAD3A) in LUAD was positively associated with the poor survival of patients, while its high expression was positively associated with the angiogenesis of LUAD...
December 5, 2023: Molecular Carcinogenesis
#37
JOURNAL ARTICLE
I T Nasir, S S Shoab, M G Bani-Hani
INTRODUCTION: The aim of this study was to evaluate the utility of our regional abdominal aortic aneurysm (AAA) screening programme in octogenarians and nonagenarians. This was to help decide whether discontinuation might be appropriate in certain instances. Primary outcomes were the number of patients who reached threshold (5.5cm) and the number where intervention was offered. Secondary outcome was cost effectiveness. METHODS: A retrospective review of a regional AAA surveillance database was carried out to evaluate outcomes...
December 1, 2023: Annals of the Royal College of Surgeons of England
#38
JOURNAL ARTICLE
Vaiva Dabravolskaité, Mometo Mao Aweys, Maarit Venermo, Harri Hakovirta, Hozan Mufty, Alexander Zimmermann, Vladimir Makaloski, Lorenz Meuli
OBJECTIVE: Current guidelines recommend diameter monitoring of small and asymptomatic abdominal aortic aneurysms (AAAs) due to the low risk of rupture. Elective AAA repair is recommended for diameters ≥ 5.5 cm in men and ≥ 5.0 cm in women. However, data supporting the efficacy of elective treatment for all patients above these thresholds are diverging. For a subgroup of patients, life expectancy might be very short, and elective AAA repair at the current threshold may not be justified...
November 21, 2023: European Journal of Vascular and Endovascular Surgery
#39
JOURNAL ARTICLE
Andrew S Warren, Kirsten Dansey, Benjamin W Starnes, Jake Hemingway, Elina Quiroga, Niten Singh, Nam Tran, Sara L Zettervall
OBJECTIVE: The modified Harborview Risk Score (HRS) is a simple measure initially derived from a single institutional dataset used to predict ruptured abdominal aortic aneurysm (RAAA) repair survival pre-operatively using basic labs and vital signs collected upon presentation. However, validation of this widely applicable scoring system has not been performed. This study aims to validate this scoring system using a large multi-institutional database. METHODS: All patients who underwent repair of a rAAA from 2011 to 2018 in the National Surgical Quality Improvement Program (NSQIP) and at a single academic medical center were included...
November 13, 2023: Journal of Vascular Surgery
#40
JOURNAL ARTICLE
Mareia Talvitie, Magnus Jonsson, Joy Roy, Rebecka Hultgren
BACKGROUND: It is unclear whether women derive mortality benefit from early repair of abdominal aortic aneurysms (AAA). The aim of this study was to compare short- and mid-term mortality for women treated at small versus large diameters. METHOD: Women receiving elective repair of AAA at small (49-54 mm) and large (≥55 mm) diameters from 2008 to 2022 were extracted from the Swedish National Registry for Vascular Surgery (n = 1642 women). The effect of diameter on 90-day, 1- and 3-year mortality was studied in logistic regression and propensity score models...
January 3, 2024: British Journal of Surgery
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