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https://www.readbyqxmd.com/read/28222596/stacking-dependent-electronic-structure-of-trilayer-graphene-resolved-by-nanospot-angle-resolved-photoemission-spectroscopy
#1
Changhua Bao, Wei Yao, Eryin Wang, Chaoyu Chen, José Avila, Maria Carmen Asensio, Shuyun Zhou
The crystallographic stacking order in multilayer graphene plays an important role in determining its electronic structure. In trilayer graphene, rhombohedral stacking (ABC) is particularly intriguing, exhibiting a fat band with an electric-field tunable band gap. Such electronic structure is distinct from simple hexagonal stacking (AAA) or typical Bernal stacking (ABA), and is promising for nanoscale electronics, optoelectronics applications. So far clean experimental electronic spectra on the first two stackings are missing because the samples are usually too small in size (µm or nm scale) to be resolved by conventional angle-resolved photoemission spectroscopy (ARPES)...
February 22, 2017: Nano Letters
https://www.readbyqxmd.com/read/28221665/totally-percutaneous-versus-surgical-cut-down-femoral-artery-access-for-elective-bifurcated-abdominal-endovascular-aneurysm-repair
#2
REVIEW
Madelaine Gimzewska, Alexander Ir Jackson, Su Ern Yeoh, Mike Clarke
BACKGROUND: Abdominal aortic aneurysms (AAAs) are a vascular condition with significant risk attached, particularly if they rupture. It is, therefore, critical to identify and repair these as an elective procedure before they rupture and require emergency surgery. Repair has traditionally been an open surgical technique that required a large incision across the abdomen. Endovascular abdominal aortic aneurysm repairs (EVARs) are now a common alternative. In this procedure, the common femoral artery is exposed via a cut-down approach and a graft introduced to the aneurysm in this way...
February 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28214511/identification-of-a-degradation-signal-sequence-within-substrates-of-the-mitochondrial-i-aaa-protease
#3
Anthony J Rampello, Steven E Glynn
The i-AAA protease is a component of the mitochondrial quality control machinery that regulates respiration, mitochondrial dynamics, and protein import. The protease is required to select specific substrates for degradation from among the diverse complement of proteins present in mitochondria, yet the rules that govern this selection are unclear. Here, we reconstruct the yeast i-AAA protease, Yme1p, to examine the in vitro degradation of two intermembrane space chaperone subunits, Tim9 and Tim10. Yme1p degrades Tim10 more rapidly than Tim9 despite high sequence and structural similarity, and loss of Tim10 is accelerated by disruption of conserved disulfide bonds within the substrate...
February 15, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28193267/abdominal-ultrasound-scanning-versus-non-contrast-computed-tomography-as-screening-method-for-abdominal-aortic-aneurysm-a-validation-study-from-the-randomized-dancavas-study
#4
Mads Liisberg, Axel C Diederichsen, Jes S Lindholt
BACKGROUND: Validating non-contrast-enhanced computed tomography (nCT) compared to ultrasound sonography (US) as screening method for abdominal aortic aneurysm (AAA) screening. METHODS: Consecutively attending men (n = 566) from the pilot study of the randomized Danish CardioVascular Screening trial (DANCAVAS trial), underwent nCT and US examination. Diameters were measured in outer-to-outer fashion. Sensitivity and specificity were done testing each modality against each other as reference standard...
February 14, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28163182/abdominal-pain-in-presence-of-small-abdominal-aortic-aneurysms-if-in-doubt-cut-it-out
#5
Efstratios Georgakarakos, Nikolaos Schoretsanitis, Georgios Koufopoulos, Konstantinos Paulou, Miltos K Lazarides
Although small (<5cm) Abdominal Aortic Aneurysm (AAA) have been associated with symptoms and indication for intervention scarcely, the clinicians should never exclude such potential association especially in the absence of other overt pathological findings. In such cases, a surgical exploration with consequent intervention, if feasible, should be justified in order to prevent a detrimental evolution in a dubious scenario. In this article we present two cases of patients with small AAA presenting with severe abdominal pain...
February 2, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28144113/clinical-implications-of-eclipse-analytical-anisotropic-algorithm-and-acuros-xb-algorithm-for-the-treatment-of-lung-cancer
#6
Gangarapu Sri Krishna, Vuppu Srinivas, Palreddy Yadagiri Reddy
The aim of the present study was to investigate the dose-volume variations of planning target volume (PTV) and organs at risks (OARs) in 15 left lung cancer patients comparing analytical anisotropic algorithm (AAA) versus Acuros XB algorithm. Originally, all plans were created using AAA with a template of dose constraints and optimization parameters, and the patients were treated using intensity modulated radiotherapy. In addition, another set of plans was created by performing only dose calculations using Acuros algorithm without doing any reoptimization...
October 2016: Journal of Medical Physics
https://www.readbyqxmd.com/read/28129470/the-water-channel-aqp1-is-expressed-in-human-atherosclerotic-vascular-lesions-and-aqp1-deficiency-augments-angiotensin-ii-induced-atherosclerosis-in-mice
#7
Pamela Wintmo, Søren H Johansen, Pernille B L Hansen, Jes S Lindholt, Sigitas Urbonavicius, Lars M Rasmussen, Peter Bie, Boye L Jensen, Jane Stubbe
AIM: The water channel aquaporin 1 (AQP1) promotes endothelial cell migration. It was hypothesized that AQP1 promotes neovascularization and growth of atherosclerotic plaques. METHODS: AQP1 immunoreactivity and protein abundance was examined in human and murine atherosclerotic lesions and aortic aneurysms. Apolipoprotein E (ApoE) knockout (-/-) and AQP1-/-ApoE-/- were developed and fed western diet (WD) for 8 and 16 weeks to accelerate the atherosclerosis process...
January 27, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28102317/time-resolved-neutron-scattering-provides-new-insight-into-protein-substrate-processing-by-a-aaa-unfoldase
#8
Ziad Ibrahim, Anne Martel, Martine Moulin, Henry S Kim, Michael Härtlein, Bruno Franzetti, Frank Gabel
We present a combination of small-angle neutron scattering, deuterium labelling and contrast variation, temperature activation and fluorescence spectroscopy as a novel approach to obtain time-resolved, structural data individually from macromolecular complexes and their substrates during active biochemical reactions. The approach allowed us to monitor the mechanical unfolding of a green fluorescent protein model substrate by the archaeal AAA+ PAN unfoldase on the sub-minute time scale. Concomitant with the unfolding of its substrate, the PAN complex underwent an energy-dependent transition from a relaxed to a contracted conformation, followed by a slower expansion to its initial state at the end of the reaction...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28087488/cathepsin-k-targeted-sub-micron-particles-for-regenerative-repair-of-vascular-elastic-matrix
#9
Brenton Jennewine, Jonathan Fox, Anand Ramamurthi
: Abdominal Aortic Aneurysms (AAA) involve slow dilation and weakening of the aortic wall due to breakdown of structural matrix components, such as elastic fibers by chronically overexpressed matrix metalloproteinases (MMPs), primarily, MMPs-2 and -9. Auto-regenerative repair of disrupted elastic fibers by smooth muscle cells (SMCs) at the AAA site is intrinsically poor and together with chronic proteolysis prevents restoration of elastin homeostasis, necessary to enable AAA growth arrest or regression to a healthy state...
January 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28079254/pharmacological-treatment-of-vascular-risk-factors-for-reducing-mortality-and-cardiovascular-events-in-patients-with-abdominal-aortic-aneurysm
#10
REVIEW
Lindsay Robertson, Edmond Atallah, Gerard Stansby
BACKGROUND: Pharmacological prophylaxis has been proven to reduce the risk of cardiovascular events in individuals with atherosclerotic occlusive arterial disease. However, the role of prophylaxis in individuals with abdominal aortic aneurysm (AAA) remains unclear. Several studies have shown that despite successful repair, those people with AAA have a poorer rate of survival than healthy controls. People with AAA have an increased prevalence of coronary heart disease and risk of cardiovascular events...
January 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28048599/su-f-t-400-clinical-comparison-of-an-imrt-plan-computed-with-four-algorithms
#11
J Barbiere, A Ndlovu
PURPOSE: This work demonstrates clinical differences in a prostate IMRT plan DVH depending on which of four common algorithms is used for computation. Previous comparisons were often based on simple static or re-optimized IMRT plans which may not be clearly indicative of the clinical end result due solely to the computation algorithm. METHODS: A step and shoot prostate multiple field IMRT plan was created in Pinnacle with a Collapsed Cone Convolution Superposition (CCCS) algorithm...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048385/su-g-brc-07-evaluation-of-aaa-focal-spot-size-for-srs-planning-using-end-to-end-dosimetric-data
#12
S Gardner, A Doemer, B Miller, N Wen, I Chetty
PURPOSE: To use end-to-end dosimetric measurements with Gafchromic film to evaluate the effects of focal spot size parameter for small-field dose calculations using AAA for SRS lesions. METHODS: A total of 13 plans, corresponding to 7 patients previously treated with cranial SRS, were analyzed in this study (target volume range:[0.67cc,13.9cc]). The plans included DCA delivery (4 plans total) and VMAT delivery (9 plans total). All plans were mapped to a solid water phantom (15 cm thickness; isocenter and film plane at 7...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048314/su-d-204-07-retrospective-correlation-of-dose-accuracy-with-regions-of-local-failure-for-early-stage-lung-cancer-patients-treated-with-stereotactic-body-radiotherapy
#13
S Devpura, H Li, C Liu, C Fraser, M Ajlouni, B Movsas, I Chetty
PURPOSE: To correlate dose distributions computed using six algorithms for recurrent early stage non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT), with outcome (local failure). METHODS: Of 270 NSCLC patients treated with 12Gyx4, 20 were found to have local recurrence prior to the 2-year time point. These patients were originally planned with 1-D pencil beam (1-D PB) algorithm. 4D imaging was performed to manage tumor motion...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048103/su-g-brc-11-impact-of-dose-calculation-algorithms-on-lung-sbrt-treatments
#14
J Rosenfield, X Yang, X Dong, E Elder, K Higgins, A Dhabaan
PURPOSE: To investigate potential dosimetrical differences between the Acuros XB (AXB) and AAA dose calculation algorithms, with a specific focus on lung SBRT treatments involving inherently high degrees of anatomical heterogeneity, small field sizes, and varying tumor locations relative to critical structures. METHODS: A cohort of 20 SBRT patients treated in our clinic was selected to include varying lung tumor locations. For each patient, the Eclipse treatment planning system was employed to generate a lung SBRT plan using the AXB dose calculation algorithm, in addition to the AAA plan previously calculated for clinical use...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047854/su-f-t-574-mlc-based-srs-beam-commissioning-minimum-target-size-investigation
#15
R Zakikhani, C Able
PURPOSE: To implement a MLC accelerator based SRS program using small fields down to 1 cm × 1 cm and to determine the smallest target size safe for clinical treatment. METHODS: Computerized beam scanning was performed in water using a diode detector and a linac-head attached transmission ion chamber to characterize the small field dosimetric aspects of a 6 MV photon beam (Trilogy-Varian Medical Systems, Inc.). The output factors, PDD and profiles of field sizes 1, 2, 3, 4, and 10 cm(2) were measured and utilized to create a new treatment planning system (TPS) model (AAA ver 11021)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047648/su-g-tep2-08-evaluation-of-plastic-scintillator-detector-for-small-field-stereotactic-patient-specific-quality-assurance
#16
Y Qin, S Gardner, Y Huang, J Kim, N Wen, I Chetty
PURPOSE: To evaluate the performance of a commercial plastic scintillator detector (PSD) for small-field stereotactic patient-specific quality assurance using flattening-filter-free (FFF) beams. METHODS: A total of ten spherical targets (volume range:[0.03cc-2cc]) were planned using Dynamic Conformal Arc(DCA-10 plans) and Volumetric Modulated Arc Therapy(VMAT-10 plans) techniques in Eclipse(AAA v.11, 1mm dose calculation grid size). Additionally, 15 previously-treated cranial and spine SRS plans were evaluated (6 DCA, 9 VMAT, volume range:[0...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047087/su-f-sps-01-accuracy-of-the-small-field-dosimetry-using-acuros-xb-and-aaa-dose-calculation-algorithms-of-eclipse-treatment-planning-system-within-and-beyond-heterogeneous-media-for-trubeam-2-0-unit
#17
G Codel, E Serin, P Pacaci, E Sanli, M Cebe, H Mabhouti, M Doyuran, E Kucukmorkoc, N Kucuk, A Altinok, D Canoglu, H Acar, H Caglar Ozkok
PURPOSE: In this study, the comparison of dosimetric accuracy of Acuros XB and AAA algorithms were investigated for small radiation fields incident on homogeneous and heterogeneous geometries METHODS: Small open fields of Truebeam 2.0 unit (1×1, 2×2, 3×3, 4×4 fields) were used for this study. The fields were incident on homogeneous phantom and in house phantom containing lung, air, and bone inhomogeneities. Using the same film batch, the net OD to dose calibration curve was obtaine dusing Trubeam 2...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046965/su-f-p-39-end-to-end-validation-of-a-6-mv-high-dose-rate-photon-beam-configured-for-eclipse-aaa-algorithm-using-golden-beam-data-for-sbrt-treatments-using-rapidarc
#18
M Ferreyra, F Salinas Aranda, D Dodat, R Sansogne, S Arbiser
PURPOSE: To use end-to-end testing to validate a 6 MV high dose rate photon beam, configured for Eclipse AAA algorithm using Golden Beam Data (GBD), for SBRT treatments using RapidArc. METHODS: Beam data was configured for Varian Eclipse AAA algorithm using the GBD provided by the vendor. Transverse and diagonals dose profiles, PDDs and output factors down to a field size of 2×2 cm2 were measured on a Varian Trilogy Linac and compared with GBD library using 2% 2mm 1D gamma analysis...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046216/su-f-p-47-estimation-of-skin-dose-by-performing-the-measurements-on-cylindrical-phantom
#19
S Bosma, M Sanders, P Aryal
PURPOSE: To evaluate the skin dose by performing the measurements on cylindrical phantom with 6X beam. METHODS: A cylindrical phantom was used to best model a patient surface. The source to surface distance (SSD) was 100 cm at phantom surface along central axis (CAX). The EBT2 films were cut into 2×2 cm2 pieces. Each piece of film was placed at CAX on phantom surface for each measurement at 0°, 15°, 30°, 45°, 60°, 75°, and 90° gantry angles for field sizes of 5×5, 10×10, 15×15, and 20×20 cm(2) respectively...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27899403/meta-analysis-of-genome-wide-association-studies-for-abdominal-aortic-aneurysm-identifies-four-new-disease-specific-risk-loci
#20
Gregory T Jones, Gerard Tromp, Helena Kuivaniemi, Solveig Gretarsdottir, Annette F Baas, Betti Giusti, Ewa Strauss, Femke N G Van't Hof, Thomas R Webb, Robert Erdman, Marylyn D Ritchie, James R Elmore, Anurag Verma, Sarah Pendergrass, Iftikhar J Kullo, Zi Ye, Peggy L Peissig, Omri Gottesman, Shefali S Verma, Jennifer Malinowski, Laura J Rasmussen-Torvik, Kenneth M Borthwick, Diane T Smelser, David R Crosslin, Mariza de Andrade, Evan J Ryer, Catherine A McCarty, Erwin P Böttinger, Jennifer A Pacheco, Dana C Crawford, David S Carrell, Glenn S Gerhard, David P Franklin, David J Carey, Victoria L Phillips, Michael J A Williams, Wenhua Wei, Ross Blair, Andrew A Hill, Thodor M Vasudevan, David R Lewis, Ian A Thomson, Jo Krysa, Geraldine B Hill, Justin Roake, Tony R Merriman, Grzegorz Oszkinis, Silvia Galora, Claudia Saracini, Rosanna Abbate, Raffaele Pulli, Carlo Pratesi, Athanasios Saratzis, Ana R Verissimo, Suzannah Bumpstead, Stephen A Badger, Rachel E Clough, Gillian Cockerill, Hany Hafez, D Julian A Scott, T Simon Futers, Simon P R Romaine, Katherine Bridge, Kathryn J Griffin, Marc A Bailey, Alberto Smith, Matthew M Thompson, Frank M van Bockxmeer, Stefan E Matthiasson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Jan D Blankensteijn, Joep A W Teijink, Cisca Wijmenga, Jacqueline de Graaf, Lambertus A Kiemeney, Jes S Lindholt, Anne Hughes, Declan T Bradley, Kathleen Stirrups, Jonathan Golledge, Paul E Norman, Janet T Powell, Steve E Humphries, Stephen E Hamby, Alison H Goodall, Christopher P Nelson, Natzi Sakalihasan, Audrey Courtois, Robert E Ferrell, Per Eriksson, Lasse Folkersen, Anders Franco-Cereceda, John D Eicher, Andrew D Johnson, Christer Betsholtz, Arno Ruusalepp, Oscar Franzén, Eric E Schadt, Johan L M Björkegren, Leonard Lipovich, Anne M Drolet, Eric L Verhoeven, Clark J Zeebregts, Robert H Geelkerken, Marc R van Sambeek, Steven M van Sterkenburg, Jean-Paul de Vries, Kari Stefansson, John R Thompson, Paul I W de Bakker, Panos Deloukas, Robert D Sayers, Seamus C Harrison, Andre M van Rij, Nilesh J Samani, Matthew J Bown
RATIONALE: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion of the heritability of AAA. OBJECTIVE: To identify additional AAA risk loci using data from all available genome-wide association studies. METHODS AND RESULTS: Through a meta-analysis of 6 genome-wide association study data sets and a validation study totaling 10 204 cases and 107 766 controls, we identified 4 new AAA risk loci: 1q32...
January 20, 2017: Circulation Research
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