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https://www.readbyqxmd.com/read/28934889/clinical-outcomes-after-endovascular-repair-and-open-surgery-to-treat-immunoglobulin-g4-related-and-nonrelated-inflammatory-abdominal-aortic-aneurysms
#1
Satomi Kasashima, Fuminori Kasashima, Atsuhiro Kawashima, Masamitsu Endo, Yasushi Matsumoto, Kengo Kawakami
PURPOSE: To compare the follow-up results of endovascular aneurysm repair (EVAR) vs open surgery (OS) for inflammatory abdominal aortic aneurysms (IAAAs) with regard to immunoglobulin G4-related diseases (IgG4-RD), which are fibrous inflammatory conditions characterized by elevated serum IgG4 concentrations and numerous infiltrations of IgG4(+) plasmacytes. METHODS: Between January 2005 and December 2015, 91 patients were treated with EVAR (begun in 2008) and 166 patients underwent OS for AAA...
September 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28934100/differences-in-the-movement-skills-and-physical-qualities-of-elite-senior-academy-rugby-league-players
#2
Matthew R E Ireton, Kevin Till, Dan Weaving, Ben Jones
The aim of the present study was to investigate (a) the differences in the movement skills and physical qualities between academy and senior rugby league players, and (b) the relationships between movement skills and physical qualities. Fifty-five male rugby league players (Senior, n=18; Under 19 n=23; Under 16, n=14) undertook a physical testing battery including anthropometric (stature & body mass), strength (isometric mid-thigh pull; IMTP) and power (countermovement jump; CMJ) qualities, alongside the athletic ability assessment (AAA; comprised of overhead squat, double lunge, single-leg Romanian deadlift, press-up and pull-up exercises)...
June 2, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28919439/pih1p-tah1p-puts-a-lid-on-hexameric-aaa-atpases-rvb1-2p
#3
Shaoxiong Tian, Ge Yu, Huan He, Yu Zhao, Peilu Liu, Alan G Marshall, Borries Demeler, Scott M Stagg, Hong Li
The Saccharomyces cerevisiae (Sc) R2TP complex affords an Hsp90-mediated and nucleotide-driven chaperone activity to proteins of small ribonucleoprotein particles (snoRNPs). The current lack of structural information on the ScR2TP complex, however, prevents a mechanistic understanding of this biological process. We characterized the structure of the ScR2TP complex made up of two AAA+ ATPases, Rvb1/2p, and two Hsp90 binding proteins, Tah1p and Pih1p, and its interaction with the snoRNP protein Nop58p by a combination of analytical ultracentrifugation, isothermal titration calorimetry, chemical crosslinking, hydrogen-deuterium exchange, and cryoelectron microscopy methods...
August 24, 2017: Structure
https://www.readbyqxmd.com/read/28916304/rationale-and-design-of-the-arrest-trial-investigating-mesenchymal-stem-cells-in-the-treatment-of-small-aaa
#4
S Keisin Wang, Linden A Green, Ashley R Gutwein, Natalie A Drucker, Raghu L Motaganahalli, Andres Fajardo, Clifford C Babbey, Michael P Murphy
BACKGROUND: Abdominal aortic aneurysms (AAA) are a major source of morbidity and mortality despite continuing advances in surgical technique and care. Although the inciting factors for AAA development continue to be elusive, accumulating evidence suggests a significant peri-aortic inflammatory response leading to degradation and dilation of the aortic wall. Previous human trials have demonstrated safety and efficacy of mesenchymal stem cells (MSCs) in the treatment of inflammation-related pathologies such as rheumatoid arthritis, graft vs host disease, and transplant rejection...
September 12, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28906250/the-aaa-protein-msp1-mediates-clearance-of-excess-tail-anchored-proteins-from-the-peroxisomal-membrane
#5
Nicholas R Weir, Roarke A Kamber, James S Martenson, Vladimir Denic
Msp1 is a conserved AAA ATPase in budding yeast localized to mitochondria where it prevents accumulation of mistargeted tail-anchored (TA) proteins, including the peroxisomal TA protein Pex15. Msp1 also resides on peroxisomes but it remains unknown how native TA proteins on mitochondria and peroxisomes evade Msp1 surveillance. We used live-cell quantitative cell microscopy tools and drug-inducible gene expression to dissect Msp1 function. We found that a small fraction of peroxisomal Pex15, exaggerated by overexpression, is turned over by Msp1...
September 14, 2017: ELife
https://www.readbyqxmd.com/read/28903051/features-of-the-chaperone-cellular-network-revealed-through-systematic-interaction-mapping
#6
Kamran Rizzolo, Jennifer Huen, Ashwani Kumar, Sadhna Phanse, James Vlasblom, Yoshito Kakihara, Hussein A Zeineddine, Zoran Minic, Jamie Snider, Wen Wang, Carles Pons, Thiago V Seraphim, Edgar Erik Boczek, Simon Alberti, Michael Costanzo, Chad L Myers, Igor Stagljar, Charles Boone, Mohan Babu, Walid A Houry
A comprehensive view of molecular chaperone function in the cell was obtained through a systematic global integrative network approach based on physical (protein-protein) and genetic (gene-gene or epistatic) interaction mapping. This allowed us to decipher interactions involving all core chaperones (67) and cochaperones (15) of Saccharomyces cerevisiae. Our analysis revealed the presence of a large chaperone functional supercomplex, which we named the naturally joined (NAJ) chaperone complex, encompassing Hsp40, Hsp70, Hsp90, AAA+, CCT, and small Hsps...
September 12, 2017: Cell Reports
https://www.readbyqxmd.com/read/28888516/effects-of-animal-assisted-activities-on-biobehavioral-stress-responses-in-hospitalized-children-a-randomized-controlled-study
#7
Sandra M Branson, Lisa Boss, Nikhil S Padhye, Thea Trötscher, Alexandra Ward
PURPOSE: This study assessed the effectiveness of animal-assisted activities (AAA) on biobehavioral stress responses (anxiety, positive and negative affect, and salivary cortisol and C-reactive protein [CRP] levels) in hospitalized children. DESIGN AND METHODS: This was a randomized, controlled study. METHOD: Forty-eight participants were randomly assigned to receive a 10-minute AAA (n=24) or a control condition (n=24). Anxiety, positive and negative affect, and levels of salivary biomarkers were assessed before and after the intervention...
September 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28876594/salmonella-typhimurium-infected-abdominal-aortic-aneurysm-endovascular-repair-with-secondary-aortoenteric-fistula-formation
#8
M Dickfos, K Garnham, J Jenkins
Endovascular aneurysm repair (EVAR) is a widely accepted and used technique for the treatment of abdominal aortic aneurysms (AAA). However, it comes with a unique set of complications, two of the rarer being infection and aorto-enteric fistula formation. Due to the infrequency of the situation, there are currently no guidelines for their management. A 75-year-old male presented with vague abdominal pain and fevers. He was diagnosed with an infected abdominal aortic EVAR stent graft on computer tomography imaging...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28862215/small-field-depth-dose-profile-of-6-mv-photon-beam-in-a-simple-air-water-heterogeneity-combination-a-comparison-between-anisotropic-analytical-algorithm-dose-estimation-with-thermoluminescent-dosimeter-dose-measurement
#9
Abhijit Mandal, Chhape Ram, Ankur Mourya, Navin Singh
AIM OF STUDY: To establish trends of estimation error of dose calculation by anisotropic analytical algorithm (AAA) with respect to dose measured by thermoluminescent dosimeters (TLDs) in air-water heterogeneity for small field size photon. MATERIALS AND METHODS: TLDs were irradiated along the central axis of the photon beam in four different solid water phantom geometries using three small field size single beams. The depth dose profiles were estimated using AAA calculation model for each field sizes...
July 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28854779/patients-opinions-regarding-research-and-management-of-abdominal-aortic-aneurysms
#10
Regent Lee, Amy Jones, Ismail Cassimjee, Ashok Handa
BACKGROUND: The epidemiology of abdominal aortic aneurysm (AAA) is changing. Outcomes for aortic surgery have improved. Biomarkers of AAA progression are emerging. We recently reported the opinions of international vascular surgery colleagues regarding research and management for AAAs. This study aimed to ascertain a real-world patients' opinion regarding the same questions. METHODS: We administered a survey to patients with AAAs. We first ascertained their views on the priority topics for research in AAA...
August 30, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28839206/grape-seed-polyphenols-play-a-protective-role-in-elastase-induced-abdominal-aortic-aneurysm-in-mice
#11
Chao Wang, Yunxia Wang, Maomao Yu, Cong Chen, Lu Xu, Yini Cao, Rong Qi
Abdominal aortic aneurysm (AAA) is a kind of disease characterized by aortic dilation, whose pathogenesis is linked to inflammation. This study aimed to determine whether grape-seed polyphenols (GSP) has anti-AAA effects and what mechanism is involved, thus to find a way to prevent occurrence and inhibit expansion of small AAA. In our study, AAA was induced by incubating the abdominal aorta of the mice with elastase, and GSP was administrated to the mice by gavage at different doses beginning on the day of the AAA inducement...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28826494/small-molecule-inhibition-of-apicomplexan-ftsh1-disrupts-plastid-biogenesis-in-human-pathogens
#12
Katherine Amberg-Johnson, Sanjay B Hari, Suresh M Ganesan, Hernan A Lorenzi, Robert T Sauer, Jacquin C Niles, Ellen Yeh
The malaria parasite Plasmodium falciparum and related apicomplexan pathogens contain an essential plastid organelle, the apicoplast, which is a key anti-parasitic target. Derived from secondary endosymbiosis, the apicoplast depends on novel, but largely cryptic, mechanisms for protein/lipid import and organelle inheritance during parasite replication. These critical biogenesis pathways present untapped opportunities to discover new parasite-specific drug targets. We used an innovative screen to identify actinonin as having a novel mechanism-of-action inhibiting apicoplast biogenesis...
August 18, 2017: ELife
https://www.readbyqxmd.com/read/28803776/mechanism-of-enzyme-repair-by-the-aaa-chaperone-rubisco-activase
#13
Javaid Y Bhat, Goran Miličić, Gabriel Thieulin-Pardo, Andreas Bracher, Andrew Maxwell, Susanne Ciniawsky, Oliver Mueller-Cajar, John R Engen, F Ulrich Hartl, Petra Wendler, Manajit Hayer-Hartl
How AAA+ chaperones conformationally remodel specific target proteins in an ATP-dependent manner is not well understood. Here, we investigated the mechanism of the AAA+ protein Rubisco activase (Rca) in metabolic repair of the photosynthetic enzyme Rubisco, a complex of eight large (RbcL) and eight small (RbcS) subunits containing eight catalytic sites. Rubisco is prone to inhibition by tight-binding sugar phosphates, whose removal is catalyzed by Rca. We engineered a stable Rca hexamer ring and analyzed its functional interaction with Rubisco...
September 7, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28795108/data-for-the-oxford-abdominal-aortic-aneurysm-study-international-survey-of-vascular-surgery-professionals
#14
Regent Lee, Amy Jones, Felicity Woodgate, Nicholas Killough, Kirthi Bellamkonda, Matthew Williams, Katherine Hurst, Lucy Fulford-Smith, Ismail Cassimjee, Ashok Handa
As part of the Oxford Abdominal Aortic Aneurysm (OxAAA) Study, we conducted an international survey of vascular surgery professionals. One aspect of the survey is as published in the International Journal of Cardiology: "International Opinion on Priorities in Research for Small Abdominal Aortic Aneurysms and the Potential Path for Research to Impact Clinical Management". This Data-in-Brief article contains a detailed method for the conduct of this survey and additional original data. In this survey, we also provided vascular surgery colleagues with contemporary epidemiologic and surgical outcome data...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28765014/follow-up-on-small-abdominal-aortic-aneurysms-using-three-dimensional-ultrasound-volume-versus-diameter
#15
Q M Ghulam, K K Bredahl, L Lönn, L Rouet, H H Sillesen, J P Eiberg
OBJECTIVES: Rupture risk in abdominal aortic aneurysms (AAAs) is assessed using AAA diameter; yet 10% of ruptures occur in a small aneurysm. This underlines the inadequacy of diameter as a standalone parameter. In this prospective follow-up study, ultrasound determined aneurysm diameter was compared with aneurysm volume determined by three dimensional ultrasound (3D-US) in a group of 179 AAAs. DESIGN: This was a prospective cohort study with repeated diameter and volume measurements by 3D-US...
October 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28741441/atmospheric-pressure-and-abdominal-aortic-aneurysm-rupture-results-from-a-time-series-analysis-and-case-crossover-study
#16
Bas B L Penning de Vries, Joé L P Kolkert, Robbert Meerwaldt, Rolf H H Groenwold
BACKGROUND: Associations between atmospheric pressure and abdominal aortic aneurysm (AAA) rupture risk have been reported, but empirical evidence is inconclusive and largely derived from studies that did not account for possible nonlinearity, seasonality, and confounding by temperature. METHODS: Associations between atmospheric pressure and AAA rupture risk were investigated using local meteorological data and a case series of 358 patients admitted to hospital for ruptured AAA during the study period, January 2002 to December 2012...
October 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28727673/exercise-training-improves-ventilatory-efficiency-in-patients-with-a-small-abdominal-aortic-aneurysm-a-randomized-controlled-study
#17
Ricardo M Lima, Baruch Vainshelboim, Rucha Ganatra, Ronald Dalman, Khin Chan, Jonathan Myers
PURPOSE: To investigate the effects of exercise training on ventilatory efficiency and physiological responses to submaximal exercise in subjects with small abdominal aortic aneurysm (AAA). METHODS: Sixty-five male patients (72.3 ± 7.0 years) were randomized to exercise training (n = 33) or usual care group (n = 32). Exercise subjects participated in a training groups for 3 mo. Cardiopulmonary exercise testing was performed before and after the study period and peak VO2, the ventilatory threshold (VT), the oxygen uptake efficiency slope (OUES), and the VE2/VCO2 slope were identified...
July 19, 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28711478/dosimetric-comparison-of-peripheral-nsclc-sbrt-using-acuros-xb-and-aaa-calculation-algorithms
#18
Chloe C H Ong, Khong Wei Ang, Roger C X Soh, Kah Ming Tin, Jerome H H Yap, James C L Lee, Christopher M Bragg
There is a concern for dose calculation in highly heterogenous environments such as the thorax region. This study compares the quality of treatment plans of peripheral non-small cell lung cancer (NSCLC) stereotactic body radiation therapy (SBRT) using 2 calculation algorithms, namely, Eclipse Anisotropic Analytical Algorithm (AAA) and Acuros External Beam (AXB), for 3-dimensional conformal radiation therapy (3DCRT) and volumetric-modulated arc therapy (VMAT). Four-dimensional computed tomography (4DCT) data from 20 anonymized patients were studied using Varian Eclipse planning system, AXB, and AAA version 10...
July 12, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28704538/intestinal-calcium-and-bile-salts-facilitate-germination-of-clostridium-difficile-spores
#19
Travis J Kochan, Madeline J Somers, Alyssa M Kaiser, Michelle S Shoshiev, Ada K Hagan, Jessica L Hastie, Nicole P Giordano, Ashley D Smith, Alyxandria M Schubert, Paul E Carlson, Philip C Hanna
Clostridium difficile (C. difficile) is an anaerobic gram-positive pathogen that is the leading cause of nosocomial bacterial infection globally. C. difficile infection (CDI) typically occurs after ingestion of infectious spores by a patient that has been treated with broad-spectrum antibiotics. While CDI is a toxin-mediated disease, transmission and pathogenesis are dependent on the ability to produce viable spores. These spores must become metabolically active (germinate) in order to cause disease. C. difficile spore germination occurs when spores encounter bile salts and other co-germinants within the small intestine, however, the germination signaling cascade is unclear...
July 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28699805/association-of-high-sensitivity-c-reactive-protein-and-abdominal-aortic-aneurysm-a-meta-analysis-and-systematic-review
#20
Yunpeng Wang, Guanghui Shen, Haiyang Wang, Ye Yao, Qingfeng Sun, Bao Jing, Gaoyan Liu, Jia Wu, Chao Yuan, Siqi Liu, Xinyu Liu, Shiyong Li, Haocheng Li
OBJECTIVE: To evaluate the association of high sensitivity C-reactive protein (hsCRP) with the presence of abdominal aortic aneurysm (AAA). METHODS: Medline, Cochrane, EMBASE, and Google Scholar databases were searched until June 22, 2016 using the keywords predictive factors, biomarkers, abdominal aortic aneurysm, prediction, high sensitivity C-reactive protein, and hsCRP. Prospective studies, retrospective studies, and cohort studies were included. RESULTS: Twelve case-control studies were included in the meta-analysis with a total of 8,345 patients (1,977 in the AAA group and 6,368 in the control group)...
July 12, 2017: Current Medical Research and Opinion
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