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https://www.readbyqxmd.com/read/29665666/-early-results-of-fenestrated-endovascular-aortic-repair-for-the-treatment-of-patients-with-thoracoabdominal-pathologies
#1
J C Zhu, X C Dai, Y D Luo, H L Fan, Z Feng, Y W Zhang, F G Hu
Objective: To evaluate the early results of fenestrated endovascular aortic repair (FEVAR) using physician-modified stent grafts (PMSGs) for the treatment of patients with thoracoabdominal pathologies. Methods: Nineteen consecutive patients who underwent FEVAR using PMSGs between April 2012 and September 2017 were retrospectively reviewed. The modality of FEVAR technique was assessed, perioperative clinical data was recorded and the early results were evaluated. Results: Indications were thoracoabdominal aortic pathologies, including juxtarenal abdominal aortic aneurysm (JAAA) ( n =12), chronic thoracoabdominal aortic dissection with aneurysmal dilatation ( n =3), thoracoabdominal aortic aneurysm (TAAA) ( n =1), infrarenal AAA with an accessory renal artery in the segment of the aneurysmal neck ( n =2) and type Ⅰ endoleak after EVAR for AAA( n =1)...
March 27, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29643016/development-and-validation-of-a-predictive-model-to-aid-in-the-management-of-intact-abdominal-aortic-aneurysms
#2
Manar Khashram, Giorgi Kvizhinadze, Ziad Khashram, Jonathan A Williman, Gregory T Jones, Justin A Roake
OBJECTIVE/BACKGROUND: Predicting outcomes prior to elective abdominal aortic aneurysm repair (AAA) requires critical decision making, as the treatment offered is a prophylactic procedure to prevent death from a ruptured AAA. The aim of this work was to develop and validate a model that may predict outcomes for patients with an AAA and hence aid in clinical decision making. METHODS: A discrete event simulation model was built to simulate the natural history of a patient with an AAA and to predict the 30 day and 2-5 year survival of patients undergoing treatment and surveillance...
April 9, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29618036/quantification-of-aortic-stiffness-and-wall-stress-in-healthy-volunteers-and-abdominal-aortic-aneurysm-patients-using-time-resolved-3d-ultrasound-a-comparison-study
#3
Emiel M J van Disseldorp, Niels J Petterson, Frans N van de Vosse, Marc R H M van Sambeek, Richard G P Lopata
Aims: Using non-invasive 3D ultrasound, peak wall stress (PWS) and aortic stiffness can be evaluated, which may provide additional criteria in abdominal aortic aneurysm (AAA) risk assessment. In this study, these measures were determined in both young and age-matched individuals, and AAA patients while its relation to age, maximum diameter, and growth was assessed statistically. Methods and results: Time-resolved 3D-US data were acquired for 30 volunteers and 65 AAA patients...
March 29, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29614976/primary-results-of-abdominal-aortic-aneurysm-screening-in-the-at-risk-residents-in-middle-china
#4
Kun Li, Kewei Zhang, Tianxiao Li, Shuiting Zhai
BACKGROUND: There is a lack of information on the epidemiological data and risk factors associated with abdominal aortic aneurysm (AAA) in Chinese population. We reported the primary results from screening five-community population in Middle China for AAA. METHODS: From March 2014 to October 2015, an AAA screening program was performed in three urban and two rural communities. These communities were randomly selected. All at-risk residents (a total of 6925) aged 40 years or older were invited to attend an ultrasound scan for AAA...
April 3, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29604852/single-molecule-diffusometry-reveals-the-nucleotide-dependent-oligomerization-pathways-of-nicotiana-tabacum-rubisco-activase
#5
Quan Wang, Andrew J Serban, Rebekka M Wachter, W E Moerner
Oligomerization plays an important role in the function of many proteins, but a quantitative picture of the oligomer distribution has been difficult to obtain using existing techniques. Here we describe a method that combines sub-stoichiometric labeling and recently developed single-molecule diffusometry to measure the size distribution of oligomers under equilibrium conditions in solution, one molecule at a time. We use this technique to characterize the oligomerization behavior of Nicotiana tabacum (Nt) Rubisco activase (Nt-Rca), a chaperone-like AAA-plus ATPase essential in regulating carbon fixation during photosynthesis...
March 28, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29582667/ultrasound-screening-for-abdominal-aortic-aneurysm-current-practice-challenges-and-controversies
#6
Ruth A Benson, Lewis Meecham, Owain Fisher, Ian M Loftus
Based on four major trials of aortic aneurysm screening from the UK, Denmark and Australia, the current UK screening programme began in 2009, and has now been expanded around the UK. Long term follow up of the original cohorts continues to demonstrate significant benefits in terms of AAA-related (OR: 0.66; 95% CI: 0.47-0.93; P =.02) and all-cause mortality (hazard ratio: 0.98; 95% confidence interval [CI]: 0.96-0.99; P = .003), and results from the first five years of the formal screening programme suggest similar success...
March 27, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29531063/single-molecule-peptide-fingerprinting
#7
Jetty van Ginkel, Mike Filius, Malwina Szczepaniak, Pawel Tulinski, Anne S Meyer, Chirlmin Joo
Proteomic analyses provide essential information on molecular pathways of cellular systems and the state of a living organism. Mass spectrometry is currently the first choice for proteomic analysis. However, the requirement for a large amount of sample renders a small-scale proteomics study challenging. Here, we demonstrate a proof of concept of single-molecule FRET-based protein fingerprinting. We harnessed the AAA+ protease ClpXP to scan peptides. By using donor fluorophore-labeled ClpP, we sequentially read out FRET signals from acceptor-labeled amino acids of peptides...
March 12, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29524228/antibiotics-induced-modulation-of-large-intestinal-microbiota-altered-aromatic-amino-acid-profile-and-expression-of-neurotransmitters-in-the-hypothalamus-of-piglets
#8
Kan Gao, Yu Pi, Chun-Long Mu, Yu Peng, Zan Huang, Wei-Yun Zhu
The evidence of gut microbiota-mediated modulation of brain function has been widely recognized from studies using germ-free rodents or animals with oral antibiotic-induced microbiota depletion. Since the number of bacteria in the large intestine greatly exceeds that found within the small intestine, large intestinal microbiota may play a crucial role in the modulation of brain function. In the present study, twelve piglets (12.08 ± 0.28 kg) fitted with a T-cannula at the distal ileum were fed a standard diet and randomly assigned to two groups (n=6) for ileal infusion of either saline (control group) or antibiotics (antibiotic group)...
March 10, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29514927/a-vcp-inhibitor-substrate-trapping-approach-vista-enables-proteomic-profiling-of-endogenous-erad-substrates
#9
Edmond Y Huang, Milton To, Erica Tran, Lorraine T Ador Dionisio, Hyejin J Cho, Katherine L M Baney, Camille I Pataki, James A Olzmann
Endoplasmic reticulum (ER)-associated degradation (ERAD) mediates the proteasomal clearance of proteins from the early secretory pathway. In this process, ubiquitinated substrates are extracted from membrane-embedded dislocation complexes by the AAA ATPase VCP and targeted to the cytosolic 26S proteasome. In addition to its well-established role in the degradation of misfolded proteins, ERAD also regulates the abundance of key proteins such as enzymes involved in cholesterol synthesis. However, due to the lack of generalizable methods, our understanding of the scope of proteins targeted by ERAD remains limited...
March 7, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29487112/cardiac-rehabilitation-protects-against-the-expansion-of-abdominal-aortic-aneurysm
#10
Atsuko Nakayama, Hiroyuki Morita, Masatoshi Nagayama, Katsuyuki Hoshina, Yukari Uemura, Hitonobu Tomoike, Issei Komuro
BACKGROUND: Virtually no reports on the effects of exercise in patients with a small abdominal aortic aneurysm (AAA) exist. METHODS AND RESULTS: We conducted a retrospective cohort study on 1515 patients with a small AAA before surgery at 2 high-volume hospitals in Tokyo, Japan, from April 2004 to September 2015. A carefully modified cardiac rehabilitation program without excessive blood pressure elevation during exercise was prescribed to 50 patients with an AAA...
February 27, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29475550/the-negative-effect-of-perioperative-red-blood-cell-transfusion-on-morbidity-and-mortality-after-major-abdominal-operations
#11
Nathan R Elwood, Allison N Martin, Florence E Turrentine, R Scott Jones, Victor M Zaydfudim
BACKGROUND: This study aims to test associations between perioperative blood transfusion and postoperative morbidity and mortality after major abdominal operations. METHODS: The 2014 ACS NSQIP dataset was queried for all patients who underwent one of the ten major abdominal operations. Separate multivariable regression models, were developed to evaluate the independent effects of perioperative blood transfusion on morbidity and mortality. RESULTS: Of 48,854 patients in the study cohort, 4887 (10%) received a blood transfusion...
February 17, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29446317/credentialing-of-radiotherapy-centres-in-australasia-for-trog-09-02-chisel-a-phase-iii-clinical-trial-on-stereotactic-ablative-body-radiotherapy-of-early-stage-lung-cancer
#12
Tomas Kron, Brent Chesson, Nicholas Hardcastle, Melissa Crain, Natalie Clements, Mark Burns, David Ball
OBJECTIVE: A randomised clinical trial comparing Stereotactic Ablative Body Radiotherapy (SABR) with conventional radiotherapy for early stage lung cancer has been conducted in Australia and New Zealand under the auspices of the TransTasman Radiation Oncology Group (NCT01014130). We report on the technical credentialing program as prerequisite for centres joining the trial. METHODS: Participating centres were asked to develop treatment plans for two test cases to assess their ability to create plans according to protocol...
February 15, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29431865/refinement-of-mlc-modelling-improves-comercial-qa-dosimetry-system-for-srs-and-sbrt-patient-specific-qa
#13
Yair Hillman, Josh Kim, Indrin Chetty, Ning Wen
PURPOSE: Mobius 3D (M3D) provides a volumetric dose verification of the treatment planning system's calculated dose using an independent beam model and a collapsed cone convolution superposition algorithm. However, there is a lack of investigation into M3D's accuracy and effectiveness for stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT) quality assurance (QA). Here, we collaborated with the vendor to develop a revised M3D beam model for SRS/SBRT cases treated with a 6X Flattening Filter Free (FFF) beam and high definition multiple leaf collimator (HDMLC) on an Edge linear accelerator...
February 12, 2018: Medical Physics
https://www.readbyqxmd.com/read/29411065/the-results-of-in-situ-prosthetic-graft-replacement-for-infected-aortic-disease
#14
Youngjin Han, Tae-Won Kwon, Sang Jun Park, Min-Jae Jeong, Kyunghak Choi, Gi-Young Ko, Sang-Oh Lee, Yong-Pil Cho
BACKGROUND: Infected aortic disease is a serious clinical condition associated with significant morbidity and mortality. This study reviewed the outcomes of in situ aortic replacement with a prosthetic graft for infected aortic disease, including primary infected abdominal aortic aneurysms (PIAAA), infected aortic prosthetic grafts (IAPG), and infected aortic stent grafts (IASG). METHODS: Twenty-eight consecutive patients who underwent in situ aortic replacement with a prosthetic graft for PIAAA, IAPG, and IASG at a single center from January 2001 to December 2015 were retrospectively analyzed...
February 6, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29400896/point-of-care-ultrasound-coming-soon-to-primary-care
#15
Paul Bornemann, Neil Jayasekera, Kevin Bergman, Mena Ramos, Jaqueline Gerhart
Point-of-care ultrasound (POCUS) has been gaining greater traction in recent years as a way to quickly (and cost-effectively) assess for conditions including systolic dysfunction, pleural effusion, abdominal aortic aneurysms (AAA), and deep vein thrombosis (DVT). It involves limited and specific ultrasound protocols performed at the bedside by the health care provider who is trying to answer a specific question and, thus, help guide treatment of the patient. In this article, we will review the evidence for the use of POCUS in 4 areas: the cardiovascular exam, the lung exam, the screening exam for AAAs, and the evaluation for DVT...
February 2018: Journal of Family Practice
https://www.readbyqxmd.com/read/29398907/patients-perceptions-of-conservative-treatment-for-a-small-abdominal-aortic-aneurysm
#16
Stephanie M Tomee, Winifred A Gebhardt, Jean-Paul Pm de Vries, Victoria C Hamelinck, Jaap F Hamming, Jan Hn Lindeman
Background: An abdominal aortic aneurysm (AAA) is a progressive, generally symptomless disease that could ultimately result in a fatal rupture. Current guidelines advise conservative follow-up, and preventive surgical repair once the risk of rupture outweighs the cost of repair (55 mm in men). In developed countries, the majority of patients are diagnosed with AAAs less than 55 mm, and so enter a period of conservative surveillance. An important question is how patients perceive and cope with risk of rupture, AAA diagnosis and treatment, and presented AAA information...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29374410/dose-calculation-accuracy-of-aaa-and-acurosxb-algorithms-for-small-central-and-interface-lung-lesions-verification-with-gafchromic-film-dosimetry
#17
Ananda Giri Babu Alagar, Kadirampatti Mani Ganesh, Karunakaran Kaviarasu
Dose calculation for small field radiotherapy with heterogeneity often involves discrepancies, so that algorithms used by treatment planning systems (TPS) should be evaluated with reference to achieving optimal treatment results. Accuracy of two model based algorithms, AcurosXB (AcXB) and the analytical anisotropic algorithm (AAA) from Eclipse TPS, were here tested. Measurements are made using Gafchromic EBT3 films with indigenously generated lung phantoms irradiated with 6 MV photons. Lung phantoms contained two types of tumor plugs, one kept at an interface attached to the chest wall in right lung (RIT) and the other at the centre of the left lung (LCT)...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29359665/pathogenic-and-therapeutic-significance-of-angiotensin-ii-type-i-receptor-in-abdominal-aortic-aneurysms
#18
Baohui Xu, Haojun Xuan, Yasunori Iida, Masaaki Miyata, Ronald L Dalman
BACKGROUND: Abdominal aortic aneurysm (AAA) is a chronic degenerative inflammatory disease. Multi-factors including genetic, environmental and lifestyles determine the onsets and progression of AAAs. Currently surgical repair remains the only effective aneurysm treatment, but no pharmacological therapy is available for limiting further enlargement of small AAAs and fetal rupture. OBJECTIVE: This article is to review our current understanding of angiotensin II (Ang II) and its type 1 receptor (AT1) in AAA pathogenesis as well as the translational potential of AT1 receptor blocker (ARB) treatment for treating clinical AAA disease...
January 22, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29352077/whole-genome-sequencing-of-suppressor-dna-mixtures-identifies-pathways-that-compensate-for-chromosome-segregation-defects-in-schizosaccharomyces-pombe
#19
Xingya Xu, Li Wang, Mitsuhiro Yanagida
Suppressor screening is a powerful method to identify genes that, when mutated, rescue the temperature sensitivity of the original mutation. Previously, however, identification of suppressor mutations has been technically difficult. Due to the small genome size of Schizosaccharomyces pombe , we developed a spontaneous suppressor screening technique, followed by a cost-effective sequencing method. Genomic DNAs of 10 revertants that survived at the restrictive temperature of the original temperature sensitive (ts) mutant were mixed together as one sample before constructing a library for sequencing...
March 2, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29290496/fucoidan-attenuates-angiotensin-ii-induced-abdominal-aortic-aneurysms-through-the-inhibition-of-c-jun-n-terminal-kinase-and-nuclear-factor-%C3%AE%C2%BAb-activation
#20
Shih-Hung Tsai, Jen-Chun Wang, Wen-I Liao, Yu-Juei Hsu, Chih-Yuan Lin, Min-Tser Liao, Po-Hsun Huang, Shing-Jong Lin
BACKGROUND: Rupture of abdominal aortic aneurysm (AAA) is one of the leading causes of sudden death among the elderly. Most incidental AAAs are below the threshold for intervention at the time of detection; however, there is no evidence that commonly used cardiovascular drugs have clinical beneficial effects on AAA progression. Therefore, in addition to current cardiovascular risk-reducing treatments, an adjunctive medical therapy targeting the regulation of extracellular matrix metabolism is still required in the clinical setting...
December 28, 2017: Journal of Vascular Surgery
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