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https://www.readbyqxmd.com/read/28506561/the-consequences-of-real-life-practice-of-early-abdominal-aortic-aneurysm-repair-a-cost-benefit-analysis
#1
S M Tomee, E Bastiaannet, M L Schermerhorn, J Golledge, J F Hamming, J H Lindeman
BACKGROUND: The reported 54 mm median intervention diameter for endovascular aneurysm repair (EVAR) in the Vascular Quality Initiative and European data from the Pharmaceutical Aneurysm Stabilisation Trial (PHAST) implies that in real life the majority of abdominal aortic aneurysm (AAA) repairs occur at diameters smaller than the consensus intervention threshold of 55 mm. This study explores the potential consequences of this practice. METHODS: The differences between real life AAA repair and consensus based intervention threshold were explored in reported data from vascular quality initiatives and PHAST...
May 12, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28502552/bifurcated-bifurcated-aneurysm-repair-is-a-novel-technique-to-repair-infrarenal-aortic-aneurysms-in-the-setting-of-iliac-aneurysms
#2
Susanna Hewon Shin, Benjamin Ware Starnes
BACKGROUND: Up to 40% of abdominal aortic aneurysms (AAAs) have coexistent iliac artery aneurysms (IAAs). In the past, successful endovascular repair required internal iliac artery (IIA) embolization, which can lead to pelvic or buttock ischemia. This study describes a technique that uses a readily available solution with a minimally altered off-the-shelf bifurcated graft in the IAA to maintain IIA perfusion. METHODS: From August 2009 to May 2015, 14 patients with AAAs and coexisting IAAs underwent repair with a bifurcated-bifurcated approach...
May 11, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28472123/inhibition-of-plasmin-mediated-tafi-activation-may-affect-development-but-not-progression-of-abdominal-aortic-aneurysms
#3
Katherine Bridge, Charlotte Revill, Fraser Macrae, Marc Bailey, Nadira Yuldasheva, Stephen Wheatcroft, Roger Butlin, Richard Foster, D Julian Scott, Ann Gils, Robert Ariens
OBJECTIVE: Thrombin-activatable fibrinolysis inhibitor (TAFI) reduces the breakdown of fibrin clots through its action as an indirect inhibitor of plasmin. Studies in TAFI-deficient mice have implicated a potential role for TAFI in Abdominal Aortic Aneurysm (AAA) disease. The role of TAFI inhibition on AAA formation in adult ApoE-/- mice is unknown. The aim of this paper was to investigate the effects of TAFI inhibition on AAA development and progression. METHODS: Using the Angiotensin II model of AAA, male ApoE-/- mice were infused with Angiotensin II 750ng/kg/min with or without a monoclonal antibody inhibitor of plasmin-mediated activation of TAFI, MA-TCK26D6, or a competitive small molecule inhibitor of TAFI, UK-396082...
2017: PloS One
https://www.readbyqxmd.com/read/28471523/laparoscopic-surgery-for-elective-abdominal-aortic-aneurysm-repair
#4
REVIEW
Lindsay Robertson, Sandip Nandhra
BACKGROUND: Abdominal aortic aneurysm (AAA) is an abnormal dilatation of the infradiaphragmatic aorta that is equal to or greater than 30 mm or a local dilatation of equal to or greater than 50% compared to the expected normal diameter of the artery. AAAs rarely occur in individuals under 50 years of age, but thereafter the prevalence dramatically increases with age, with men at a six-fold greater risk of developing an AAA than women. Prevalence of AAA has been reported to range from 1...
May 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28462867/monte-carlo-dose-calculation-in-presence-of-low-density-media-application-to-lung-sbrt-treated-during-dibh
#5
S Beilla, T Younes, L Vieillevigne, M Bardies, X Franceries, L Simon
PURPOSE: Commercial algorithms used in Radiotherapy include approximations that are generally acceptable. However their limits can be seen when confronted with small fields and low-density media. These conditions exist during the treatment of lung cancers with Stereotactic Body Radiation Therapy (SBRT) achieved with the "Deep Inspiration Breath Hold" (DIBH) technique. A Monte Carlo (MC) model of a linear accelerator was used to assess the performance of two algorithms (Varian Acuros and AAA) in these conditions...
April 24, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28454907/a-methodology-for-developing-anisotropic-aaa-phantoms-via-additive-manufacturing
#6
Sergio Ruiz de Galarreta, Raúl Antón, Aitor Cazón, Ender A Finol
An Abdominal Aortic Aneurysm (AAA) is a permanent focal dilatation of the abdominal aorta at least 1.5 times its normal diameter. The criterion of maximum diameter is still used in clinical practice, although numerical studies have demonstrated the importance of biomechanical factors for rupture risk assessment. AAA phantoms could be used for experimental validation of the numerical studies and for pre-intervention testing of endovascular grafts. We have applied multi-material 3D printing technology to manufacture idealized AAA phantoms with anisotropic mechanical behavior...
April 19, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28445810/circulating-cadmium-concentration-and-risk-of-aortic-aneurysms-a-nested-case-control-study-within-the-malm%C3%A3-diet-and-cancer-cohort
#7
Björn Fagerberg, Yan Borné, Gerd Sallsten, J Gustav Smith, Stefan Acosta, Margaretha Persson, Olle Melander, Niklas Forsgard, Anders Gottsäter, Bo Hedblad, Lars Barregard, Gunnar Engström
BACKGROUND AND AIMS: Diet and smoking expose the general population to cadmium (Cd), which is a toxic metal that accumulates in the arterial wall. In experimental studies, Cd causes reductions in proliferation of smooth muscle cells and cellular synthesis of procollagen. The aim of this study was to examine whether blood Cd levels, a valid measure of Cd exposure, are associated with increased risk of abdominal aortic aneurysm (AAA). METHODS: All middle-aged men and women enrolled in the Malmö Diet and Cancer study (n = 30 447) were followed from the baseline examination in 1991-1996 through 2009...
April 8, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28438902/crucial-role-of-rock2-mediated-phosphorylation-and-upregulation-of-fhod3-in-the-pathogenesis-of-angiotensin-ii-induced-cardiac-hypertrophy
#8
Qing Zhou, Si-Si Wei, Hong Wang, Qian Wang, Wei Li, Gang Li, Jian-Wen Hou, Xiao-Meng Chen, Jie Chen, Wei-Ping Xu, Yi-Gang Li, Yue-Peng Wang
Cardiac hypertrophy is characterized by increased myofibrillogenesis. Angiotensin II (Ang-II) is an essential mediator of the pressure overload-induced cardiac hypertrophy in part through RhoA/ROCK (small GTPase/Rho-associated coiled-coil containing protein kinase) pathway. FHOD3 (formin homology 2 domain containing 3), a cardiac-restricted member of diaphanous-related formins, is crucial in regulating myofibrillogenesis in cardiomyocytes. FHOD3 maintains inactive through autoinhibition by an intramolecular interaction between its C- and N-terminal domains...
June 2017: Hypertension
https://www.readbyqxmd.com/read/28431866/circulating-micrornas-signature-correlates-with-positive-18-f-fluorodeoxyglucose-positron-emission-tomography-in-patients-with-abdominal-aortic-aneurysm
#9
Audrey Courtois, Betty Nusgens, Nancy Garbacki, Roland Hustinx, Pierre Gomez, Jean-Olivier Defraigne, Alain C Colige, Natzi Sakalihasan
BACKGROUND: Prediction of abdominal aortic aneurysm (AAA) rupture is a challenging issue. Small noncoding microRNAs (miRNAs) are potent regulators of gene expression and are considered as valuable circulating biomarkers. Recently, [(18)F]fluorodeoxyglucose (FDG) uptake detected by positron emission tomography (PET) in AAA was correlated with cellular and molecular alterations involved in wall instability and its potential rupture. Our study aimed at identifying circulating miRNAs correlated with a positive PET that could help discriminate patients at high risk of rupture...
April 18, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28431107/double-fixation-for-abdominal-aortic-aneurysm-repair-using-afx-body-and-endurant-proximal-aortic-cuff-mid-term-results
#10
Miltiadis I Matsagkas, George Kouvelos, Konstantinos Spanos, Athanasios Athanasoulas, Athanasios Giannoukas
Our goal was to evaluate the use of an AFX main body combined with an Endurant proximal aortic cuff to treat selected patients with an abdominal aortic aneurysm (AAA) associated with anatomical challenges, such as a small distal aortic diameter and a hostile aortic neck. A retrospective analysis of prospectively collected data from 2 vascular institutions identified 14 elective patients with an AAA (all men, 73.5 ± 5.1 years) treated with the AFX main body combined with an Endurant proximal aortic cuff...
April 17, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28416191/assessment-of-international-outcomes-of-intact-abdominal-aortic-aneurysm-repair-over-9-years
#11
J Budtz-Lilly, M Venermo, S Debus, C-A Behrendt, M Altreuther, B Beiles, Z Szeberin, N Eldrup, G Danielsson, I Thomson, P Wigger, M Björck, I Loftus, K Mani
BACKGROUND: Case mix and outcomes of complex surgical procedures vary over time and between regions. This study analyses peri-operative mortality after intact abdominal aortic aneurysm (AAA) repair in 11 countries over 9 years. METHODS: Data on primary AAA repair from vascular surgery registries in 11 countries for the years 2005-2009 and 2010-2013 were analysed. Multivariate adjusted logistic regression analyses were carried out to adjust for variations in case mix...
April 13, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28416190/flow-mediated-dilatation-and-progression-of-abdominal-aortic-aneurysms
#12
R Lee, K Bellamkonda, A Jones, N Killough, F Woodgate, M Williams, I Cassimjee, A Handa
OBJECTIVE/BACKGROUND: Biomarker(s) for prediction of the future progression rate of abdominal aortic aneurysms (AAA) may be useful to stratify the management of individual patients. AAAs are associated with features of systemic inflammation and endothelial dysfunction. Flow mediated dilatation (FMD) of the brachial artery is a recognised non-invasive measurement for endothelial function. We hypothesised that FMD is a potential biomarker of AAA progression and reflects the temporal changes of endothelial function during AAA progression...
April 13, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28409004/effect-of-%C3%AE-blockade-on-lung-function-exercise-performance-and-dynamic-hyperinflation-in-people-with-arterial-vascular-disease-with-and-without-copd
#13
Angela Key, Matthew Parry, Malcolm A West, Rebecca Asher, Sandy Jack, Nick Duffy, Francesco Torella, Paul P Walker
INTRODUCTION: β Blockers are important treatment for ischaemic heart disease and heart failure; however, there has long been concern about their use in people with chronic obstructive pulmonary disease (COPD) due to fear of symptomatic worsening of breathlessness. Despite growing evidence of safety and efficacy, they remain underused. We examined the effect of β-blockade on lung function, exercise performance and dynamic hyperinflation in a group of vascular surgical patients, a high proportion of who were expected to have COPD...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28360209/preclinical-evaluation-of-rym1-a-novel-mmp-targeted-tracer-for-imaging-aneurysm
#14
Jakub Toczek, Yunpeng Ye, Kiran Gona, Hye-Yeong Kim, Jinah Han, Mahmoud Razavian, Reza Golestani, Jiasheng Zhang, Terence Wu, Jae-Joon Jung, Mehran Sadeghi
Matrix metalloproteinases (MMPs) play a key role in abdominal aortic aneurysm (AAA) development. Accordingly, MMP-targeted imaging provides important information regarding vessel wall biology in the course of aneurysm development. Given the small size of the vessel wall and its proximity with blood, molecular imaging of aneurysm optimally requires highly sensitive tracers with rapid blood clearance. To this end, we developed a novel hydrosoluble zwitterionic MMP inhibitor, RYM, based on which a pan-MMP tracer, RYM1, was designed...
March 30, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28352916/a-threonine-turnstile-defines-a-dynamic-amphiphilic-binding-motif-in-the-aaa-atpase-p97-allosteric-binding-site
#15
James C Burnett, Chaemin Lim, Brian D Peyser, Lalith P Samankumara, Marina Kovaliov, Raffaele Colombo, Stacie L Bulfer, Matthew G LaPorte, Ann R Hermone, Connor F McGrath, Michelle R Arkin, Rick Gussio, Donna M Huryn, Peter Wipf
The turnstile motion of two neighboring threonines sets up a dynamic side chain interplay that can accommodate both polar and apolar ligands in a small molecule allosteric protein binding site. A computational model based on SAR data and both X-ray and cryo-EM structures of the AAA ATPase p97 was used to analyze the effects of paired threonines at the inhibitor site. Specifically, the Thr side chain hydroxyl groups form a hydrogen bonding network that readily accommodates small, highly polar ligand substituents...
May 16, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28297459/on-the-use-of-a-convolution-superposition-algorithm-for-plan-checking-in-lung-stereotactic-body-radiation-therapy
#16
Nicholas Hardcastle, Bradley M Oborn, Annette Haworth
Stereotactic body radiation therapy (SBRT) aims to deliver a highly conformal ablative dose to a small target. Dosimetric verification of SBRT for lung tumors presents a challenge due to heterogeneities, moving targets, and small fields. Recent software (M3D) designed for dosimetric verification of lung SBRT treatment plans using an advanced convolution-superposition algorithm was evaluated. Ten lung SBRT patients covering a range of tumor volumes were selected. 3D CRT plans were created using the XiO treatment planning system (TPS) with the superposition algorithm...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297432/difference-in-dose-volumetric-data-between-the-analytical-anisotropic-algorithm-the-dose-to-medium-and-the-dose-to-water-reporting-modes-of-the-acuros-xb-for-lung-stereotactic-body-radiation-therapy
#17
Wambaka A Mampuya, Mitsuhiro Nakamura, Yoshinori Hirose, Takashi Ishigaki, Takashi Mizowaki, Masahiro Hiraoka
The purpose of this study was to evaluate the difference in dose-volumetric data between the analytical anisotropic algorithms (AAA) and the two dose reporting modes of the Acuros XB, namely, the dose to water (AXB-Dw) and dose to medium (AXB-Dm) in lung stereotactic body radiotherapy (SBRT). Thirty-eight plans were generated using the AXB-Dm in Eclipse Treatment Planning System (TPS) and then recalculated with the AXB-Dw and AAA, using identical beam setup. A dose of 50 Gy in 4 fractions was prescribed to the isocenter and the planning target volume (PTV) D95%...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28287739/the-application-of-metabolic-profiling-to-abdominal-aortic-aneurysm-research
#18
Mahim Irfan Qureshi, Michele Greco, Panagiotis Andrea Vorkas, Elaine Holmes, Alun H Davies
Rationale Abdominal aortic aneurysm (AAA) is a complex disease posing diagnostic and therapeutic challenges. Metabonomics may aid in the diagnosis of AAA, determination of individualised risk, discovery of therapeutic targets, and improve understanding of pathogenesis. Objective To review the diversity and outcomes of existing AAA metabonomic research. Methods and Results A systematic review has been performed. Original research studies applying metabonomics to human aneurysmal disease were included. Seven relevant articles were identified: four studies were based on plasma/serum metabolite profiling, and three studies examined aneurysmal tissue...
March 13, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28280809/metal-organic-complex-functionalized-protein-nanopore-sensor-for-aromatic-amino-acids-chiral-recognition
#19
Yanli Guo, Aihua Niu, Feifei Jian, Ying Wang, Fujun Yao, Yongfeng Wei, Lei Tian, Xiaofeng Kang
Chiral recognition at single-molecule level for small active molecules is important, as exhibited by many nanostructures and molecular assemblies in biological systems, but it presents a significant challenge. We report a simple and rapid sensing strategy to discriminate all enantiomers of natural aromatic amino acids (AAA) using a metal-organic complex-functionalized protein nanopore, in which a chiral recognition element and a chiral recognition valve were equipped. A trifunctional molecule, heptakis-(6-deoxy-6-amino)-β-cyclodextrin (am7βCD), was non-covalently lodged within the nanopore of an α-hemolysin (αHL) mutant, (M113R)7-αHL...
March 10, 2017: Analyst
https://www.readbyqxmd.com/read/28273341/still-equivalent-for-dose-calculation-in-the-monte-carlo-era-a-comparison-of-free-breathing-and-average-intensity-projection-ct-datasets-for-lung-sbrt-using-three-generations-of-dose-calculation-algorithms
#20
Kristina Zvolanek, Rongtao Ma, Christina Zhou, Xiaoying Liang, Shuo Wang, Vivek Verma, Xiaofeng Zhu, Qinghui Zhang, Joseph Driewer, Chi Lin, Weining Zhen, Andrew Wahl, Su-Min Zhou, Dandan Zheng
PURPOSE: Inhomogeneity dose modeling and respiratory motion description are two critical technical challenges for lung stereotactic body radiotherapy, an important treatment modality for small size primary and secondary lung tumors. Recent studies revealed lung density-dependent target dose differences between Monte Carlo (Type-C) algorithm and earlier algorithms. Therefore, this study aimed to investigate the equivalence of the two most popular CT datasets for treatment planning, free breathing (FB) and average intensity projection (AIP) CTs, using Type-C algorithms, and comparing with two older generation algorithms (Type-A and Type-B)...
March 8, 2017: Medical Physics
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