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https://www.readbyqxmd.com/read/27834080/cardiac-dysfunction-in-association-with-increased-inflammatory-markers-in-primary-aldosteronism
#1
Jung Soo Lim, Sungha Park, Sung Il Park, Young Taik Oh, Eunhee Choi, Jang Young Kim, Yumie Rhee
BACKGROUND: Oxidative stress in primary aldosteronism (PA) is thought to worsen aldosterone-induced damage by activating proinflammatory processes. Therefore, we investigated whether inflammatory markers associated with oxidative stress is increased with negative impacts on heart function as evaluated by echocardiography in patients with PA. METHODS: Thirty-two subjects (mean age, 50.3±11.0 years; 14 males, 18 females) whose aldosterone-renin ratio was more than 30 among patients who visited Severance Hospital since 2010 were enrolled...
November 3, 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27616614/anatomopathological-changes-of-the-cardiac-conduction-system-in-sudden-cardiac-death-particularly-in-infants-advances-over-the-last-25-years
#2
REVIEW
Giulia Ottaviani, L Maximilian Buja
Sudden cardiac death (SCD) is defined as the unexpected death without an obvious noncardiac cause that occurs within 1 h of witnessed symptom onset (established SCD) or within 24 h of unwitnessed symptom onset (probable SCD). In the United States, its incidence is 69/100,000 per year. Dysfunctions of the cardiac conduction and autonomic nervous systems are known to contribute to SCD pathogenesis, even if most clinicians and cardiovascular pathologists lack experience with detailed examination of the cardiac conduction system and fail to recognize lesions that are crucial to explain the SCD itself...
November 2016: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/27555054/efficacy-and-safety-of-renal-sympathetic-denervation-on-dogs-with-pressure-overload-induced-heart-failure
#3
Pingan Chen, Shuilong Leng, Yishan Luo, Shaonan Li, Zicheng Huang, Zhenxi Liu, Zhen Liu, Jie Wang, Xiaoming Lei
BACKGROUND: In dogs with heart failure (HF) induced by overload pressure, the role of renal sympathetic denervation (RSD) on heart failure and in the renal artery is unclear. Therefore, we investigated the efficacy and safety of RSD in dogs with pressure overload-induced heart failure. METHODS: Twenty mongrel dogs were divided into a sham-operated group, an HF group and an HF + RSD group. In the sham-operated group, the abdominal aorta was located but was not constricted, in the HF group, the abdominal aorta was constricted without RSD, and the HF+RSD group underwent RSD with constriction of the abdominal aorta after 10 weeks...
July 26, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27485033/diffusion-tensor-imaging-and-histology-of-developing-hearts
#4
Osama M Abdullah, Thomas Seidel, MarJanna Dahl, Arnold David Gomez, Gavin Yiep, Julia Cortino, Frank B Sachse, Kurt H Albertine, Edward W Hsu
Diffusion tensor imaging (DTI) has emerged as a promising method for noninvasive quantification of myocardial microstructure. However, the origin and behavior of DTI measurements during myocardial normal development and remodeling remain poorly understood. In this work, conventional and bicompartmental DTI in addition to three-dimensional histological correlation were performed in a sheep model of myocardial development from third trimester to postnatal 5 months of age. Comparing the earliest time points in the third trimester with the postnatal 5 month group, the scalar transverse diffusivities preferentially increased in both left ventricle (LV) and right ventricle (RV): secondary eigenvalues D2 increased by 54% (LV) and 36% (RV), whereas tertiary eigenvalues D3 increased by 85% (LV) and 67% (RV)...
October 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27072956/shensong-yangxin-ssyx-ameliorates-disordered-excitation-transmission-by-suppressing-cardiac-collagen-hyperplasia-in-rabbits-with-chronic-myocardial-infarction
#5
Song Dang, Cong-Xin Huang, Xi Wang, Xin Wang, Juan Hu, He Huang
The traditional Chinese medicine Shensong Yangxin (SSYX) can improve the clinical symptoms of arrhythmia in an integrated manner. This study aimed to investigate the electrophysiological effect of SSYX on the hearts of myocardial-infarcted rabbits and further explore the mechanism by which SSYX alleviates myocardial fibrosis. Myocardial infarction (MI) was established in rabbits by ligation of the left circumflex coronary. The rabbits were treated with SSYX (0.5 g/kg/d) or saline for 8 weeks by oral administration...
April 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/26983926/epicardial-fat-thickness-and-primary-aldosteronism
#6
G Iacobellis, L Petramala, C Marinelli, C Calvieri, L Zinnamosca, A Concistrè, G Iannucci, G De Toma, C Letizia
Primary aldosteronism (PA) is associated with increased cardiovascular risk and left ventricle (LV) changes. Given its peculiar biomolecular and anatomic properties, excessive epicardial fat, the heart-specific visceral fat depot, can affect LV morphology. Whether epicardial fat can be associated with aldosterone and LV mass (LVM) in patients with PA is unknown. We performed ultrasound measurement of the epicardial fat thickness (EAT) in 79 consecutive newly diagnosed patients with PA, 59 affected by bilateral adrenal hyperplasia (IHA), 20 aldosterone-producing adenoma (APA), and 30 patients with essential hypertension (low renin hypertension) (EH)...
April 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/26708369/preliminary-experience-in-the-use-of-an-extracellular-matrix-cormatrix-as-a-tube-graft-word-of-caution
#7
Narutoshi Hibino, Patrick McConnell, Toshiharu Shinoka, Mahim Malik, Mark Galantowicz
A number of materials have been used for the repair of congenital heart disease. However, an ideal material is yet to be discovered. Decellularized extracellular matrix from porcine small intestinal submucosa (CorMatrix) has been developed and commercialized as a biological tissue substitute. This has been used for valvuloplasty, sepal defect repair, or angioplasty as a patch. In this study, we demonstrate our preliminary experience using CorMatrix as a tube graft. A retrospective review of 13 patients who underwent cardiac surgery using CorMatrix as an interposition graft was performed (10 patients for central pulmonary artery reconstruction in comprehensive stage II surgery for hypoplastic left-sided heart syndrome and 3 patients for aortic arch reconstruction in interrupted aortic arch)...
2015: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/26664858/electrical-and-myocardial-remodeling-in-primary-aldosteronism
#8
Mario Curione, Luigi Petramala, Claudio Savoriti, Marisa Verrenti, Erika Baiocco, Stephanie Salvatore, Laura Zinnamosca, Gino Iannucci, Susanna Sciomer, Claudio Letizia
OBJECTIVE AND DESIGN: Primary aldosteronism (PA) represents the most common cause of secondary hypertension. A higher risk of cardiovascular events has been reported in patients with PA than in otherwise similar patients with essential hypertension (EH). So far, only a few studies investigated the electrocardiographic changes in PA patients compared to EH patients. METHODS: To investigate the electrocardiographic changes and heart remodeling in PA, we enrolled 61 consecutive patients, 30 with PA [12 with aldosterone-producing adrenal cortical adenoma (APA) and 18 with bilateral adrenal hyperplasia-idiopathic adrenal hyperplasia] and 30 with EH...
2014: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/26650456/hyperhomocysteinemia-induced-upper-extremity-deep-vein-thrombosis-and-pulmonary-embolism-in-a-patient-with-methyltetrahydrofolate-reductase-mutation-a-case-report-and-literature-review
#9
Lin Gao, Bangaruraju Kolanuvada, Geetha Naik, Yingzhong Zhang, Min Zhao, Lili Sun, Dariush Alaie, Richard L Petrillo
The study highlights pulmonary embolism and deep vein thrombosis by methylene tetrahydrofolate reductase (MTHFR) deficiency-related hyperhomocysteinemia occurring in rare locations of left veins superior to the heart extensively. A 59-year-old white man with history of leg pain, smoking, weight loss, benign prostatic hyperplasia, lipoma and panic attack presented with shortness of breath and chest pain for 2 days precipitated by not feeling well for months. The diagnostic workup revealed pulmonary embolism and deep vein thrombosis in the left subclavian vein which extended throughout the left brachiocephalic vein to the superior vena cava and left jugular vein...
September 2016: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/26452998/optical-coherence-tomography-for-characterization-of-cardiac-allograft-vasculopathy-in-late-survivors-of-pediatric-heart-transplantation
#10
Fabrizio Tomai, Leonardo De Luca, Alessandro Petrolini, Luca Di Vito, Anna S Ghini, Pierfrancesco Corvo, Giovanni De Persio, Francesco Parisi, Giacomo Pongiglione, Maria Giulia Gagliardi, Francesco Prati
BACKGROUND: Optical coherence tomography (OCT) has been shown to reliably detect cardiac allograft vasculopathy (CAV). In recent studies performed in adult heart transplant (HTx) recipients, OCT revealed the presence of vulnerable plaques and complicated coronary artery lesions, thus challenging the current concept that CAV disease is a diffuse concentric and fibrosing vasculopathy. The aim of our study was to characterize CAV by OCT in a young population of HTx recipients. METHODS: We prospectively enrolled 21 young HTx recipients (mean age 27 years, range 22 to 38 years) to undergo OCT of the left anterior descending coronary artery (LAD) in addition to annual CAV screening by coronary angiography and virtual histology intravascular ultrasound (VH-IVUS)...
January 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/26419987/-association-between-clinical-features-and-histopathological-findings-in-patients-with-left-ventricular-non-compaction-cardiomyopathy
#11
Hong Zhao, Yang Sun, Laifeng Song, Qingzhi Wang, Yan Chu, Jie Huang, Shengshou Hu
OBJECTIVE: To investigate the association between clinical and histopathological features in patients with left ventricular non-compaction cardiomyopathy (LVNC). METHODS: Histopathological examinations were made on 11 LVNC recipient hearts from June 2004 to June 2014 in Fuwai Hospital, myocardial ultrastructure changes were detected using transmission electron microscopy. Association between clinical and pathological features were analyzed. RESULTS: Patients were (24 ± 11) years old...
May 2015: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/26387177/-effects-of-total-flavonoids-of-propolis-on-apoptosis-of-myocardial-cells-of-chronic-heart-failure-and-its-possible-mechanism-in-rats
#12
Hai-hua Wang, Jin Zeng, Hai-zhen Wang, Yu-xin Jiang, Jing Wang, Ping-ping Zhou
OBJECTIVE: To investigate the effects of total flavonoids of propolis (TFP) on apoptosis of myocardial cells of chronic heart failure and its possible mechanism in rats. METHODS: Six male SD rats were randomly selected as normal control group, the remaining rats were made as chronic heart failure (CHF) model by intraperitoneal injection of adriamycin. The rats in the successful model were randomly divided into five groups (n = 6): CHF group, total flavonoids of propolis low dose group (LD group), total flavonoids of propolis middle dose group (MD group), total flavonoids of propolis high dose group (HD group), digoxin group (DIG group)...
May 2015: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/25934968/comparison-of-saline-irrigated-catheter-vs-temperature-controlled-catheter-for-renal-denervation-in-a-canine-model
#13
COMPARATIVE STUDY
Zhenglong Wang, Shaojie Chen, Tingquan Zhou, Li Su, Zhiyu Ling, Jinqi Fan, Weijie Chen, Huaan Du, Jiayi Lu, Yanping Xu, Zhen Tan, Hanxuan Yang, Xinyu Hu, Chengzhi Li, Xue Yan, Guangxin Hu, Chang Liu, Yuehui Yin
BACKGROUND: The effectiveness of catheter-based renal denervation (RDN) remains controversial. Although the reasons for this have not yet been elucidated, ineffective denervation appears to be an important factor. The present study aimed to investigate the difference in RDN between a saline-irrigated catheter (SIC) and a temperature-controlled catheter (TCC). METHODS: Dogs (n = 6) from the Kunming province in Chinese were ablated; the SIC was introduced into the right renal artery, while the TCC was introduced into the left renal artery...
December 2015: American Journal of Hypertension
https://www.readbyqxmd.com/read/25913485/analysis-of-flow-dynamics-in-right-ventricular-outflow-tract
#14
Denis A Berdajs, Selim Mosbahi, Dominique Charbonnier, Roger Hullin, Ludwig K von Segesser
BACKGROUND: The mechanism behind early graft failure after right ventricular outflow tract (RVOT) reconstruction is not fully understood. Our aim was to establish a three-dimensional computational fluid dynamics (CFD) model of RVOT to investigate the hemodynamic conditions that may trigger the development of intimal hyperplasia and arteriosclerosis. METHODS: Pressure, flow, and diameter at the RVOT, pulmonary artery (PA), bifurcation of the PA, and left and right PAs were measured in 10 normal pigs with a mean weight of 24...
July 2015: Journal of Surgical Research
https://www.readbyqxmd.com/read/25810382/ang-ii-modulation-of-cardiac-growth-and-remodeling-in-immature-fetal-sheep
#15
COMPARATIVE STUDY
Jeremy Sandgren, Thomas D Scholz, Jeffrey L Segar
ANG II increases fetal blood pressure and stimulates fetal heart growth; however, little is known regarding its direct effects on cardiomyocytes in vivo. We sought to determine whether ANG II stimulates heart growth and cardiomyocyte hypertrophy and/or hyperplasia in utero in the immature fetal heart independent of the effects on cardiac afterload. In twin gestation, fetal sheep at ∼100 days gestation (term 145 days), one fetus received a chronic (6 days) infusion of ANG II alone (50 μg·kg(-1)·min(-1)) or ANG II plus nitroprusside (NTP) to attenuate the increase in blood pressure; noninstrumented twins served as controls...
June 1, 2015: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/25587367/tonsillitis-and-sore-throat-in-children
#16
REVIEW
Klaus Stelter
Surgery of the tonsils is still one of the most frequent procedures during childhood. Due to a series of fatal outcomes after hemorrhage in children in Austria in 2006, the standards and indications for tonsillectomy have slowly changed in Germany. However, no national guidelines exist and the frequency of tonsil surgery varies across the country. In some districts eight times more children were tonsillectomized than in others. A tonsillectomy in children under six years should only be done if the child suffers from recurrent acute bacterially tonsillitis...
2014: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
https://www.readbyqxmd.com/read/25537546/-anomalous-origin-of-the-left-coronary-artery-from-the-pulmonary-artery-in-infants-clinical-features-and-the-perioperative-treatment-strategies
#17
Cheng Zhang, Zhiwei Zhang, Yiqun Ding, Shushui Wang, Chengcheng Pang, Yufen Li
OBJECTIVE: To investigate the clinical features and individualized treatment strategies for infants with anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA). METHOD: Data of 25 less than 1-year-old infants with ALCAPA who presented at Guangdong Cardiovascular Institute between 2006 and 2013 were retrospectively reviewed. The patients' cardiac function was evaluated with echocardiography during follow-up. RESULT: Most patients presented with symptoms of heart failure, such as tachypnea, diaphoresis, poor feeding, failure to thrive etc...
October 2014: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/25531103/trpm4-gene-invalidation-leads-to-cardiac-hypertrophy-and-electrophysiological-alterations
#18
Marie Demion, Jérôme Thireau, Mélanie Gueffier, Amanda Finan, Ziad Khoueiry, Cécile Cassan, Nicolas Serafini, Franck Aimond, Mathieu Granier, Jean-Luc Pasquié, Pierre Launay, Sylvain Richard
RATIONALE: TRPM4 is a non-selective Ca2+-activated cation channel expressed in the heart, particularly in the atria or conduction tissue. Mutations in the Trpm4 gene were recently associated with several human conduction disorders such as Brugada syndrome. TRPM4 channel has also been implicated at the ventricular level, in inotropism or in arrhythmia genesis due to stresses such as ß-adrenergic stimulation, ischemia-reperfusion, and hypoxia re-oxygenation. However, the physiological role of the TRPM4 channel in the healthy heart remains unclear...
2014: PloS One
https://www.readbyqxmd.com/read/25478348/evaluation-profile-of-thyroid-nodule-by-fnac-in-the-rural-population-of-khanpur-kalan-sonepat-haryana
#19
Hemlata T Kamra, Ruchi Agarwal, Parveen Rana, Rajnish Kalra, Swarn Kaur, Amrita Duhan, Sanjay Verma, Deepti Agarwal
BACKGROUND: Thyroid disease is most common endocrine disorder and is different from other endocrine diseases because of its visible swelling and ease of diagnosis. If left untreated, thyroid disease makes a person more prone for heart disease, infertility and osteoporosis. In India, significant burden of thyroid diseases exist with an estimation of around 42 million cases. The thyroid status and autoimmune status of adult Indian population in the post iodinization phase is largely unknown...
October 2014: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/25405496/cardiovascular-abnormalities-and-impaired-exercise-performance-in-adolescents-with-congenital-adrenal-hyperplasia
#20
Alberto M Marra, Nicola Improda, Donatella Capalbo, Andrea Salzano, Michele Arcopinto, Amato De Paulis, Maria Alessio, Andrea Lenzi, Andrea M Isidori, Antonio Cittadini, Mariacarolina Salerno
CONTEXT: PATIENTS with classic congenital adrenal hyperplasia (CAH) are treated with lifelong glucocorticoids (GCs). Cardiovascular and metabolic effects of such therapy in adolescents have never been quantified. OBJECTIVE: Our objective was to investigate left ventricular (LV) morphology, function, and exercise performance in adolescents with CAH. DESIGN AND SETTING: We conducted a cross-sectional and controlled study conducted at a tertiary referral center...
February 2015: Journal of Clinical Endocrinology and Metabolism
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