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Sinapic acid

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https://www.readbyqxmd.com/read/28718636/long-chain-alkyl-esters-of-hydroxycinnamic-acids-as-promising-anticancer-agents-selective-induction-of-apoptosis-in-cancer-cells
#1
José C J M D S Menezes, Najmeh Edraki, Shrivallabh Kamat, Mahsima Khoshneviszadeh, Zahra Kayani, Hossein Hadavand Mirzaei, Ramin Miri, Nasrollah Erfani, Maryam Nejati, José A S Cavaleiro, Tiago B Silva, Luciano Saso, Fernanda M Borges, Omidreza Firuzi
Cancer is the major cause of morbidity and mortality worldwide. Hydroxycinnamic acids (HCAs) are naturally-occurring compounds and their alkyl esters may possess enhanced biological activities. We evaluated C4, C14, C16 and C18 alkyl esters of p-coumaric, ferulic, sinapic and caffeic acids (19 compounds) for their cytotoxic activity against four human cancer cells and also examined their effect on cell cycle alteration and apoptosis induction. The tetradecyl (1c) and hexadecyl (1d) esters of p-coumaric acid and tetradecyl ester of caffeic acid (4c), but not the parental HCAs, were selectively effective against MOLT-4 (human lymphoblastic leukemia) cells with IC50 values of 0...
July 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28714341/identification-of-phenolic-compounds-from-the-leaf-part-of-teucrium-pseudo-scorodonia-desf-collected-from-algeria
#2
Karima Belarbi, Fawzia Atik-Bekkara, Imad Abdelhamid El Haci, Ilhem Bensaid, Chahrazed Bekhechi
In the present paper,we reported for the first time, the identification of the phenolic compounds in butanolic fraction obtained from the leaf part of Teucrium pseudo-Scorodonia Desf. collected from Algeria using RP-HPLC-PDA (Reversed Phase High Performance Liquid Chromatography/Photo Diode Array) technique. Several standards were used for this purpose. The analysis led to the identification of six phenolic acids (ferulic, sinapic, rosmarinic, syringique, caffeic, p-coumaric acids) and one flavonoid (rutin), the last one, has interesting pharmacological properties...
July 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28697384/schizosaccharomyces-pombe-and-saccharomyces-cerevisiae-yeasts-in-sequential-fermentations-effect-on-phenolic-acids-of-fermented-kei-apple-dovyalis-caffra-l-juice
#3
P P Minnaar, N P Jolly, V Paulsen, H W Du Plessis, M Van Der Rijst
Kei-apple (Dovyalis caffra) is an evergreen tree indigenous to Southern Africa. The fruit contains high concentrations of l-malic acid, ascorbic acid, and phenolic acids. Kei-apple juice was sequentially inoculated with Schizosaccharomyces pombe and Saccharomyces cerevisiae yeasts. A reference fermentation using only S. cerevisiae was included. The fermentation was monitored by recording mass loss. At the end of fermentation, twelve untrained judges conducted free choice aroma profiling on the fruit wines. The Kei-apple juice and wines were analysed for total titratable acidity, total soluble solids, pH, alcohol, l-malic acid, and phenolic acids...
July 6, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28692293/spectroscopic-properties-and-conformational-analysis-of-methyl-ester-of-sinapic-acid-in-various-environments
#4
Bogdan Smyk, Grzegorz Mędza, Adam Kasparek, Maciej Pyrka, Ignacy Gryczynski, Maciej Maciejczyk
A methyl ester of sinapic acid (MESA) has recently attracted attention due to its antioxidant action. This paper presents results of a study on the spectral and physicochemical properties of MESA, using quantum chemistry (QC), steady-state (absorption and fluorescence) and time-resolved fluorescence techniques (TCSPC). The pKa of the phenol group in the ground state was determined (8.6). The pKa* values in the excited state calculated from the Förster cycle (1.9) and from fluorescence spectra (8.5) differed significantly but the experimental data suggested that the first was the more probable one...
July 10, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28686978/sinapic-acid-modulates-nrf2-ho-1-signaling-pathway-in-cisplatin-induced-nephrotoxicity-in-rats
#5
Mushtaq Ahmad Ansari
BACKGROUND: Cisplatin-induced nephrotoxicity is related to increased reactive oxygen species and inflammatory cytokines in the kidney. Sinapic acid (SA) has both antioxidant and anti-inflammatory activities. AIMS: We determined the effects of SA on cisplatin-induced nephrotoxicity in rats, and the potential mechanisms by which it augments antioxidant responses and attenuates nephrotoxicity related to oxidative/nitrosative stress, apoptosis, and inflammation. METHODS: Kidney function markers (i...
July 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28587634/sinapic-acid-or-its-derivatives-interfere-with-abscisic-acid-homeostasis-during-arabidopsis-thaliana-seed-germination
#6
Baodi Bi, Jingliang Tang, Shuang Han, Jinggong Guo, Yuchen Miao
BACKGROUND: Sinapic acid and its esters have broad functions in different stages of seed germination and plant development and are thought to play a role in protecting against ultraviolet irradiation. To better understand the interactions between sinapic acid esters and seed germination processes in response to various stresses, we analyzed the role of the plant hormone abscisic acid (ABA) in the regulation of sinapic acid esters involved in seed germination and early seedling growth...
June 6, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28534439/hypolipidemic-and-hepatoprotective-activities-of-rosemary-and-thyme-in-gentamicin-treated-rats
#7
A M Hegazy, A S Abdel-Azeem, H M Zeidan, K S Ibrahim, Em El Sayed
Rosemary ( Rosmarinus officinalis; RM) and thyme ( Thymus vulgaris; TV) are used as remedies. We designed this work to investigate the preventive effect of aqueous extracts of RM or TV on the gentamicin (GM)-induced hepatotoxicity and abnormalities of lipid profile in rats. Both plant extracts exhibited an in vitro antioxidant activity as determined by the 1,1-diphenyl-2-picrylhydrazyl assay. Radical scavenging activity for TV extract was 48.7% and for RM extract was 25.6%. Polyphenolic determination by high-performance liquid chromatography for both extracts revealed that catechin, coumarin, cinnamic acid and rutin were detected in both extracts...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28531830/isotope-coded-derivatization-based-lc-esi-ms-ms-methods-using-a-pair-of-novel-reagents-for-quantification-of-hydroxycinnamic-acids-and-hydroxybenzoic-acids-in-fermented-brown-rice-product
#8
Shoujiro Ogawa, Kiriko Takafuji, Sumi Tsubuku, Yukiko Horie, Shigeo Ikegawa, Tatsuya Higashi
Hydroxycinnamic acids (HCAs) and hydroxybenzoic acids (HBAs) are antioxidant phytochemicals found in rice and effective for the prevention of human diseases including cancer. FBRA, which is a functional food manufactured by fermenting brown rice and rice bran with Aspergillus oryzae, has been demonstrated to have chemopreventive effects against carcinogenesis in various organs. In this study, we developed methods for the relative and absolute quantification of ferulic acid, sinapic acid, caffeic acid, protocatechuic acid and syringic acid in the FBRA and raw material (RM; unfermented brown rice and rice bran) samples by LC/ESI-MS/MS combined with derivatization using a newly developed reagent, N-(2-aminoethyl)-4-(diethylamino)benzamide (ADB) and its deuterium-coded analog, d-ADB...
May 2, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28530609/phenolic-compounds-of-the-australian-native-herb-prostanthera-rotundifolia-and-their-biological-activities
#9
Kitty S C Tang, Izabela Konczak, Jian Zhao
The chemical identity and bioactivities of phenolic components of the Australian native herb Prostanthera rotundifolia were studied. Phenolic compounds were extracted with 80% (v/v) aqueous methanol and purified by liquid chromatography. The antioxidant capacity of the extract and its inhibiting activity against α-glucosidase, pancreatic lipase and hyaluronidase were determined. Phenolic compounds were identified by a combination of HPLC-PDA, LC-high resolution MS (LC-HRMS), LC-tandem MS (LC-MS/MS) and nuclear magnetic resonance (NMR) spectroscopy...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28530557/improving-oxidative-stability-of-echium-oil-emulsions-fabricated-by-microfluidics-effect-of-ionic-gelation-and-phenolic-compounds
#10
Talita A Comunian, Raheleh Ravanfar, Inar Alves de Castro, Robin Dando, Carmen S Favaro-Trindade, Alireza Abbaspourrad
Echium oil is rich in omega-3 fatty acids, which are important because of their benefits to human health; it is, however, unstable. The objective of this work was the coencapsulation of echium oil and quercetin or sinapic acid by microfluidic and ionic gelation techniques. The treatments were analyzed utilizing optical and scanning electron microscopy, encapsulation yield, particle size, thermogravimetry, Fourier transform infrared spectroscopy, stability under stress conditions, and oil oxidative/phenolic compound stability for 30days at 40°C...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28475126/phenolic-compositions-and-antioxidant-properties-in-bark-flower-inner-skin-kernel-and-leaf-extracts-of-castanea-crenata-sieb-et-zucc
#11
Phung Thi Tuyen, Tran Dang Xuan, Do Tan Khang, Ateeque Ahmad, Nguyen Van Quan, Truong Thi Tu Anh, La Hoang Anh, Truong Ngoc Minh
In this study, different plant parts (barks, flowers, inner skins, kernels and leaves) of Castanea crenata (Japanese chestnut) were analyzed for total phenolic, flavonoid, and tannin contents. Antioxidant properties were evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), reducing power, and β-carotene bleaching methods. The highest total phenolic and tannin contents were found in the inner skins (1034 ± 7.21 mg gallic acid equivalent/g extract and 253...
May 5, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28450018/interaction-between-natural-antioxidants-derived-from-cinnamon-and-cocoa-in-binary-and-complex-mixtures
#12
Dimas Rahadian Aji Muhammad, Danar Praseptiangga, Davy Van de Walle, Koen Dewettinck
Cinnamon and cocoa are known to be valuable sources of bioactive phytochemicals, mainly the polyphenols. This paper investigates the potential antioxidant activity of cinnamon and cocoa extract and the interaction of their mixtures by various in vitro tests. Moreover, the combination effect of their constituents in a binary mixture was studied. Two representative active compounds of chocolate (epicatechin, catechin) were combined with seven of cinnamon (gallic acid, tannic acid, quercetin, sinapic acid, cinnamic acid, eugenol and cinnamaldehyde) in multilevel ratios...
September 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28449398/feeding-induced-phenol-production-in-capsicum-annuum-l-influences-spodoptera-litura-f-larval-growth-and-physiology
#13
Vijaya Movva, Usha Rani Pathipati
We studied the role of induced plant phenols as a defense response to insect herbivory. Phenolic compounds were induced in Capsicum annuum L., the source of many culinary peppers, after feeding by different stages of the insect pest, Spodoptera litura F. The phenols were identified and quantified using high performance liquid chromatography (HPLC) and effects produced by these phenols on larval development were studied. Vanillic acid was identified in plants challenged by second, fourth, and fifth instar larvae, but not in plants challenged by third instar nor unchallenged plants...
May 2017: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/28424532/stemness-and-differentiation-potential-recovery-effects-of-sinapic-acid-against-ultraviolet-a-induced-damage-through-the-regulation-of-p38-mapk-and-nf-%C3%AE%C2%BAb
#14
Young Sun Hwang, See-Hyoung Park, Mingyeong Kang, Sae Woong Oh, Kwangseon Jung, Yong Seek Park, Jongsung Lee
Ultraviolet A (UVA) irradiation exerts negative effects on stemness and differentiation potential of stem cells. This study aimed to explore the effect of sinapic acid on UVA-irradiation-induced damages to stemness and differentiation potential of human-adipose-tissue-derived mesenchymal stem cells (hAMSCs) and its UVA-antagonist mechanisms. Sinapic acid attenuated UVA-induced reduction in the proliferative potential and stemness by upregulating OCT4, SOX2, and NANOG. In addition, sinapic acid significantly recovered UVA-induced reduction in expression level of hypoxia-inducible factor (HIF)-1α...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28391725/identification-and-in-vitro-antioxidant-activities-of-phenolic-compounds-isolated-from-cynoglossum-cheirifolium-l
#15
Bensaid Ilhem, Atik Bekkara Fawzia, El Haci Imad Abdelhamid, Belarbi Karima, Beddou Fawzia, Bekhechi Chahrazed
In an extensive search for bioactive compounds from plant sources, the quantitative and qualitative characterisation of the compounds present in Cynoglossum cheirifolium extracts was studied. Total phenolic and flavonoid contents were determined by spectrophotometric techniques. In vitro antioxidant and radical scavenging profiling was determined through DPPH(•) scavenging activity and Ferric reducing antioxidant power (FRAP). Our study showed that leaves produce more phenolic compounds, followed by flowering aerial part...
April 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28378865/mustard-inspired-delivery-shuttle-for-enhanced-blood-brain-barrier-penetration-and-effective-drug-delivery-in-glioma-therapy
#16
Nan Wang, Pei Sun, Mingming Lv, Gangsheng Tong, Xin Jin, Xinyuan Zhu
Effective penetration through the blood-brain barrier (BBB) remains a challenge for the treatment of many brain diseases. In this study, a small molecule, sinapic acid (SA), extracted from mustard, was selected as a novel bioinspired BBB-permeable ligand for efficient drug delivery in glioma treatment. SA was conjugated on the surface of zwitterionic polymer poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)-encapsulated bovine serum albumin (BSA)-based nanoparticles, yielding nBSA-SA. The PMPC shell serves as a protective layer to prolong the in vivo blood circulation time with a better chance to cross the BBB...
May 2, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28372151/quantification-of-phytoprostanes-bioactive-oxylipins-and-phenolic-compounds-of-passiflora-edulis-sims-shell-using-uhplc-qqq-ms-ms-and-lc-it-dad-ms-ms
#17
Sonia Medina, Jacinta Collado-González, Federico Ferreres, Julián Londoño-Londoño, Claudio Jiménez-Cartagena, Alexandre Guy, Thierry Durand, Jean-Marie Galano, Angel Gil-Izquierdo
The genus Passiflora, comprising about 500 species, is the largest in the Passion flower family. Passiflora edulis Sims f. edulis (gulupa) is one of the most important fruits cultivated in Colombia. In recent years and due to its organoleptic and bioactive properties, its exports have significantly increased. In this work, six new bioactive oxylipins -phytoprostanes - were detected in gulupa shell by a UHPLC-QqQ-MS/MS method: F1t-phytoprostanes and D1t-phytoprostanes were the predominant and minor classes, respectively...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28369955/effect-of-extrusion-on-physicochemical-properties-digestibility-and-phenolic-profiles-of-grit-fractions-obtained-from-dry-milling-of-normal-and-waxy-corn
#18
Sheetal Thakur, Narpinder Singh, Amritpal Kaur, Baljit Singh
Extrusion behavior of grits obtained from 3 successive reductions of dry milling of 2 normal corn types and 1 waxy corn was studied at different extrusion temperatures (ET). The grit from each reduction stage (RS) showed the presence of base-hydrolyzed bound protocatechuic acid, p-coumaric acid, sinapic acid, ferulic acid, and quercetin, and the concentrations of these decreased after acid hydrolysis and that of gallic acid increased. African tall grit from all RSs showed the highest average specific mechanical energy (SME) and torque, while waxy corn grit had the lowest...
May 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28343034/bioactivities-of-achillea-phrygia-and-bupleurum-croceum-based-on-the-composition-of-phenolic-compounds-in%C3%A2-vitro-and-in-silico-approaches
#19
Gokhan Zengin, Gizem Bulut, Adriano Mollica, Mehmet Zeki Haznedaroglu, Ahmet Dogan, Abdurrahman Aktumsek
This study presents the effects of the Achillea phrygia Boiss. et Bal. and Bupleurum croceum Fenzl. extracts obtained by different solvents (ethyl acetate, methanol and water) on selected enzyme inhibitory effects and antioxidant ability with screening bioactive compounds. Total and individual bioactive compounds were detected by spectrophotometric and HPLC-DAD techniques. Antioxidant abilities were evaluated by different methods including free radical scavenging (ABTS and DPPH), reducing power (CUPRAC and FRAP), phosphomolybdenum and metal chelating...
March 22, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28334920/spe-hplc-determination-of-chlorogenic-and-phenolic-acids-in-coffee
#20
Pelin Köseoglu Yilmaz, Ufuk Kolak
A new solid phase extraction-high-performance liquid chromatography method with ultraviolet detection was developed and validated for the determination of three chlorogenic acids (5-O-caffeoylquinic, 3-O-caffeoylquinic and 4-O-caffeoylquinic acids) and six phenolic acids (caffeic, ferulic, sinapic, protocatechuic, p-hydroxybenzoic acid (PHBA) and vanillic acid (VA)) in coffee bean samples. Extraction was performed using hydrophilic-lipophilic balance cartridges. Separations were accomplished using a C18 guard column (10 × 2...
March 18, 2017: Journal of Chromatographic Science
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