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Sinapic acid

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https://www.readbyqxmd.com/read/29287408/hydroxycinnamic-acids-loaded-in-lipid-core-nanocapsules
#1
Giuseppe Granata, Grazia M L Consoli, Raffaella Lo Nigro, Corrada Geraci
Ferulic, caffeic, sinapic, and coumaric acids, belonging to the class of hydroxycinnamic acids (HAs), are bioactive polyphenols widespread in the plant kingdom and present in the human diet. Due to their biological properties and effects in the prevention of various diseases associated with oxidative stress, HAs can be exploited for attractive nutraceutical applications. Starting from this and in order to increase bioaccessibility, we encapsulated HAs in lipid-core nanocapsules (NCs) based on a biodegradable and biocompatible poly(ε-caprolactone) polymer...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29286544/direct-analysis-by-time-of-flight-secondary-ion-mass-spectrometry-tof-sims-reveals-action-of-bacterial-laccase-mediator-system-on-both-hardwood-and-softwood-samples
#2
Robyn E Goacher, Erick J Braham, Courtney L Michienzi, Robert M Flick, Alexander F Yakunin, Emma R Master
The modification and degradation of lignin play a vital role in carbon cycling as well as production of biofuels and bioproducts. The possibility of using bacterial laccases for the oxidation of lignin offers a route to utilize existing industrial protein expression techniques. However, bacterial laccases are most frequently studied on small model compounds that do not capture the complexity of lignocellulosic materials. This work studied the action of laccases from Bacillus subtilis and Salmonella typhimurium (EC 1...
December 29, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/29277227/phenolic-antioxidants-of-foxtail-and-little-millet-cultivars-and-their-inhibitory-effects-on-%C3%AE-amylase-and-%C3%AE-glucosidase-activities
#3
P M Pradeep, Yadahally N Sreerama
Evaluation of phenolic contents and their in vitro bioactivities of six diverse cultivars of foxtail and little millets revealed that their total phenolic content ranged from 19.42 to 24.12 µmol ferulic acid equivalents/g. The soluble fraction accounted for more than 80% of the total phenolic and flavonoid contents. Ferulic, caffeic and sinapic acids were the predominant phenolic acids, and luteolin and kaempferol were major flavonoids in the soluble fractions of millets. However, ferulic and p-coumaric acids were abundant in the bound fractions...
May 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29243030/sinapic-acid-inhibits-the-il-1%C3%AE-induced-inflammation-via-mapk-downregulation-in-rat-chondrocytes
#4
Xiaojian Huang, Qiyong Pan, Zekai Mao, Rui Zhang, Xiaohu Ma, Yang Xi, Hongbo You
Osteoarthritis (OA) is a degenerative joint disease frequently seen in the elderly population. Sinapic acid (SA), a commonly found phenolic acid, has been pharmacologically evaluated for its anti-inflammation effects in various studies. To explore its potential therapeutic role for OA, rat chondrocytes were treated with IL-1β (10 ng/ml) with different concentrations of SA in vitro. Our study revealed that SA could inhibit the IL-1β-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2). Consistent with these findings, the increased protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase (Cox)-2 could also be downregulated by SA...
December 14, 2017: Inflammation
https://www.readbyqxmd.com/read/29239525/isolation-of-sinapic-acid-from-broccoli-using-molecularly-imprinted-polymers
#5
Heba Hosny, Nesrine El Gohary, Engy Saad, Heba Handoussa, Rasha M El Nashar
A molecularly imprinted polymer was synthesized for the purpose of sinapic acid isolation from Egyptian nutraceutical Botrytis italica, L. (broccoli) due to its prominent medicinal and wide pharmacological activities. A computational study was first developed to determine the optimal template to functional monomer molar ratio. Based on the computational results, five polymers were synthesized using a bulk polymerization method with sinapic acid as the template molecule. Evaluation of the synthesized polymers binding performance was carried out using batch rebinding assay, which revealed that the molecularly imprinted polymer of molar ratio (1:4:20), template to functional monomer (4-vinyl pyridine) to crosslinker (ethylene glycol dimethacrylate) was of optimum performance, thus, this polymer was applied for sinapic acid isolation from closely related analogues...
December 14, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29226479/metabolite-profiling-and-isolation-of-biologically-active-compounds-from-scadoxus-puniceus-a-highly-traded-south-african-medicinal-plant
#6
Devashan Naidoo, Lenka Poštová Slavětínská, Adeyemi O Aremu, Jiri Gruz, Ondrej Biba, Karel Doležal, Johannes Van Staden, Jeffrey F Finnie
Scadoxus puniceus (Amaryllidaceae), a medicinal plant of high value in South Africa, is used as a component of a traditional herbal tonic prescribed to treat several ailments. Ultra-high performance liquid chromatography-tandem mass spectrometry quantified the phenolic compounds in different organs of S. puniceus. Gravity column chromatography was used to separate fractions and active compounds. The structure of these compounds was determined using 1D and 2D nuclear magnetic resonance and mass spectroscopic techniques...
December 11, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29211033/in-vitro-and-in-vivo-antioxidant-and-anti-hyperglycemic-activities-of-moroccan-oat-cultivars
#7
Ilias Marmouzi, El Mostafa Karym, Nezha Saidi, Bouchra Meddah, Mourad Kharbach, Azlarab Masrar, Mounya Bouabdellah, Layachi Chabraoui, Khalid El Allali, Yahia Cherrah, My El Abbes Faouzi
Improvement of oat lines via introgression is an important process for food biochemical functionality. This work aims to evaluate the protective effect of phenolic compounds from hybrid Oat line (F11-5) and its parent (Amlal) on hyperglycemia-induced oxidative stress and to establish the possible mechanisms of antidiabetic activity by digestive enzyme inhibition. Eight phenolic acids were quantified in our samples including ferulic, p-hydroxybenzoic, caffeic, salicylic, syringic, sinapic, p-coumaric and chlorogenic acids...
December 6, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29195662/differentiation-of-modern-and-ancient-varieties-of-common-wheat-by-quantitative-capillary-electrophoretic-profile-of-phenolic-acids
#8
Roberto Gotti, Elisa Amadesi, Jessica Fiori, Sara Bosi, Valeria Bregola, Ilaria Marotti, Giovanni Dinelli
Phenolic compounds have received great attention among the health promoting phytochemicals in common wheat (Triticum aestivum L.), mainly because of their strong antioxidant properties. In the present study a simple Capillary Zone Electrophoresis (CZE) method with UV detection was optimized and validated for the quantitation of six of the most important phenolic acids in whole grain i.e., sinapic, ferulic, syringic, p-coumaric, vanillic and p-hydroxybenzoic acid. The separation was achieved in a running buffer composed of sodium phosphate solution (50 mM) in water/methanol 80:20 (v/v) at pH 6...
November 26, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29193097/in-vitro-digestibility-free-and-bound-phenolic-profiles-and-antioxidant-activity-of-thermally-treaded-eragrostis-tef-l
#9
Eva Koubová, Martina Mrázková, Daniela Sumczynski, Jana Orsavová
BACKGROUND: Total phenolic content, the most common phenolics profile and antioxidant activity have been determined in free and bound phenolic fractions of thermally treated brown and white teff grains. RESULTS: Phenolic content in raw brown and white teff (1540 and 992 mg GAE kg-1 ) as well as antioxidant activity (6.3 and 5.5 mmol TE kg-1 ) were higher in free phenolic fractions. The most significant decrease in total phenolics has been observed after the application of sous-vide method (35% for brown and 11% for white variety)...
November 28, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29139309/polyphenolic-characterisation-of-plant-mixture-lisosan%C3%A2-reduction-and-its-hypocholesterolaemic-effect-in-high-fat-diet-fed-mice
#10
Rossella Russo, Laura Pucci, Lucia Giorgetti, Július Árvay, Francesco Vizzarri, Vincenzo Longo, Luisa Pozzo
Lisosan® Reduction is a plant mixture produced from powder of fermented Triticum aestivum (Lisosan® G), Desmodium adscendens, Malus domestica, Picrorhiza kurroa and Hordeum vulgare. The aim of this study was to characterise the phenolic profile of Lisosan® Reduction and to evaluate the effects of aqueous extract on mice fed a high fat diet (HFD). Syringic acid, trans sinapic acid and neochlorogenic acid were identified by HPLC-DAD to be the dominant polyphenols of Lisosan® Reduction, followed by vitexin, trans p-coumeric acid and trans ferulic acid...
November 15, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29137712/hydrophilic-interaction-liquid-chromatography-of-hydroxy-aromatic-carboxylic-acid-positional-isomers
#11
Ashley E Richardson, Neil D Danielson
Hydrophilic interaction liquid chromatography (HILIC) has become increasingly popular as an alternative to reversed phase LC due to its ease of separating complex polar compound mixtures and the compatibility of the mobile phase with mass spectrometry (MS). Using a plain silica column (150  mm × 4.6  mm), we have shown a mixture containing three hydroxybenzoic acid isomers plus syringic and vanillic acid and three hydroxycinnamic acid isomers plus ferulic and sinapic acid can be separated using a mobile phase comprised of 90% acetonitrile (MeCN) and 10% 20 mM ammonium acetate at pH 6 in under 45 min...
December 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29135028/effects-of-hydrolyzed-rapeseed-cake-extract-on-the-quality-characteristics-of-mayonnaise-dressing
#12
Ye-Seul Kim, Jeung-Hee Lee
Combined fractions (H2 O and 30% and 50% ethanol) of crude rapeseed cake extracts with 80% ethanol were hydrolyzed with NaOH solution. The hydrolyzed extract showed significantly higher contents of total phenolics (41.8 mg SAE/g) and sinapic acid (425.8 mg/g), as well as higher 1,1-diphenyl-2-picryl-hydrazyl radical-scavenging capacity (91.98 RSC%) than the crude extract (P < 0.05). Antimicrobial activity of the hydrolyzed extract was remarkably higher than that of the crude extract against selected Gram-positive and Gram-negative bacteria as well as yeast, as determined by the minimum inhibitory concentration method...
November 14, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29122176/evaluating-the-response-to-fusarium-ananatum-inoculation-and-antifungal-activity-of-phenolic-acids-in-pineapple
#13
Bastien Barral, Marc Chillet, Jerome Minier, Mathieu Léchaudel, Sabine Schorr-Galindo
Fusarium ananatum causes fruitlet core rot (FCR) in pineapple (Ananas comosus var. comosus) when the fruit reaches maturity. Hidden symptoms make it difficult to assess the disease, regardless of its stage, and basic questions concerning the involvement of the phenolic compounds in response to infection remain unknown. A direct inoculation method of F. ananatum in pineapple fruitlets was developed to monitor the growth of black spots and the changes in phenolic acids and ascorbic acid concentration under controlled conditions...
December 2017: Fungal Biology
https://www.readbyqxmd.com/read/29104269/characterization-of-free-conjugated-and-bound-phenolic-acids-in-seven-commonly-consumed-vegetables
#14
Yuan Gao, Shuai Ma, Meng Wang, Xiao-Yuan Feng
Phenolic acids are thought to be beneficial for human health and responsible for vegetables' health-promoting properties. Free, conjugated, and bound phenolic acids of seven commonly consumed vegetables, including kidney bean, cow pea, snow pea, hyacinth bean, green soy bean, soybean sprouts and daylily, from the regions of Beijing, Hangzhou, and Guangzhou, were identified and quantified by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Three vegetables, namely green soy bean, soybean sprouts, and daylily (Hemerocallisfulva L...
November 1, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29099862/effects-of-coronatine-elicitation-on-growth-and-metabolic-profiles-of-lemna-paucicostata-culture
#15
Jin-Young Kim, Hye-Youn Kim, Jun-Yeong Jeon, Dong-Min Kim, Yaoyao Zhou, Jae Soung Lee, Heayyean Lee, Hyung-Kyoon Choi
In this study, the effects of coronatine treatment on the growth, comprehensive metabolic profiles, and productivity of bioactive compounds, including phenolics and phytosterols, in whole plant cultures of Lemna paucicostata were investigated using gas chromatography-mass spectrometry (GC-MS) coupled with multivariate statistical analysis. To determine the optimal timing of coronatine elicitation, coronatine was added on days 0, 23, and 28 after inoculation. The total growth of L. paucicostata was not significantly different between the coronatine treated groups and the control...
2017: PloS One
https://www.readbyqxmd.com/read/29095793/low-dose-sinapic-acid-abates-the-pyroptosis-of-macrophages-via-downregulation-of-lncrna-malat1-in-rats-with-diabetic-atherosclerosis
#16
Yong Han, Hong Qiu, Xing Pei, Yigang Fan, Hongyan Tian, Jie Geng
Pyroptosis is a type of programmed cell death, which has been associated with multiple inflammatory diseases including diabetic atherosclerosis (DA). The study aims to explore the role of sinapic acid (SA) in the pyroptosis of macrophages in diabetic atherosclerosis. Our results from the in vivo experiments showed that low-dose (≤ 50 mg/Kg) chronic SA adiministration suppressed serum endothelin 1 (ET-1) and interleukine-1β (IL-1β) contents, pyroptotic death of bone marrow derived macrophages (BMDMs), and the expression of pyroptotic proteins ASC, NRLP3 and Caspase-1...
October 27, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29036919/a-two-step-bioconversion-process-for-canolol-production-from-rapeseed-meal-combining-an-aspergillus-niger-feruloyl-esterase-and-the-fungus-neolentinus-lepideus
#17
Elise Odinot, Frédéric Fine, Jean-Claude Sigoillot, David Navarro, Oscar Laguna, Alexandra Bisotto, Corinne Peyronnet, Christian Ginies, Jérôme Lecomte, Craig B Faulds, Anne Lomascolo
Rapeseed meal is a cheap and abundant raw material, particularly rich in phenolic compounds of biotechnological interest. In this study, we developed a two-step bioconversion process of naturally occurring sinapic acid (4-hydroxy-3,5-dimethoxycinnamic acid) from rapeseed meal into canolol by combining the complementary potentialities of two filamentous fungi, the micromycete Aspergillus niger and the basidiomycete Neolentinus lepideus. Canolol could display numerous industrial applications because of its high antioxidant, antimutagenic and anticarcinogenic properties...
October 14, 2017: Microorganisms
https://www.readbyqxmd.com/read/29023751/the-use-of-factorial-design-to-evaluate-the-oxidation-of-oils-containing-different-types-of-omega-3-fatty-acids
#18
Thamyris Dias Fabiano Agnes, Gabriela Grassmann Roschel, Inar Alves Castro
N3 FA promote beneficial effects on cardiovascular diseases, but they are highly susceptible to oxidation, which leads to the formation of potentially toxic secondary products. In this study, the antioxidant capacity of natural compounds (sinapic acid and rutin) was evaluated using an accelerated model to oxidize the oils. Five inducers (Temperature, Fe(2+) , AAPH, Ascorbyl palmitate and AMVN) were combined in a factorial design to accelerate the oxidation of three oils (flaxseed, echium and fish) containing different sources of n3 FA...
October 11, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28992569/4-alkyliden-azetidinones-modified-with-plant-derived-polyphenols-antibacterial-and-antioxidant-properties
#19
Daria Giacomini, Rosario Musumeci, Paola Galletti, Giulia Martelli, Lorenzo Assennato, Gianni Sacchetti, Alessandra Guerrini, Enrico Calaresu, Marianna Martinelli, Clementina Cocuzza
Antimicrobial resistance is one of the major and growing concerns in hospital- and community acquired infections, and new antimicrobial agents are therefore urgently required. It was reported that oxidative stress could contribute to the selection of resistant bacterial strains, since reactive oxygen species (ROS) revealed to be an essential driving force. In the present work 4-alkylidene-azetidinones, a new class of antibacterial agents, were functionalized with phytochemical polyphenolic acids such as protocatechuic, piperonyl, caffeic, ferulic, or sinapic acids and investigated as dual target antibacterial-antioxidant compounds...
September 23, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28990237/dereplication-by-hplc-dad-esi-ms-ms-and-screening-for-biological-activities-of-byrsonima-species-malpighiaceae
#20
Karina Fraige, Alessandra Cristina Dametto, Maria Luiza Zeraik, Larissa de Freitas, Amanda Correia Saraiva, Alexandra Ivo Medeiros, Ian Castro-Gamboa, Alberto José Cavalheiro, Dulce Helena S Silva, Norberto Peporine Lopes, Vanderlan S Bolzani
INTRODUCTION: Byrsonima species have been used in the treatment of gastrointestinal and gynecological inflammations, skin infections and snakebites. Based on their biological activities, it is important to study other organisms from this genus and to identify their metabolites. OBJECTIVES: To determine the metabolic fingerprinting of methanol and ethyl acetate extracts of four Byrsonima species (B. intermedia, B. coccolobifolia, B. verbascifolia and B. sericea) by HPLC-DAD-ESI-MS/MS and evaluate their in vitro antioxidant, anti-glycation, anti-inflammatory and cytotoxic activities...
October 9, 2017: Phytochemical Analysis: PCA
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