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Sinapic acid

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https://www.readbyqxmd.com/read/28920692/roseochelin-b-an-algaecidal-natural-product-synthesized-by-the-roseobacter-phaeobacter-inhibens-in-response-to-algal-sinapic-acid
#1
Rurun Wang, Mohammad R Seyedsayamdost
The secondary metabolome of the representative Roseobacter, Phaeobacter inhibens, was examined in response to algal sinapic acid. In addition to roseobacticides, sinapic acid induced the production of two new natural products, roseochelin A and B, which were characterized by NMR and X-ray crystallography. Functional assays showed that roseochelin B binds iron and is algaecidal against the algal host Emiliania huxleyi. It appears to be produced by a rarely observed combination of nonenzymatic and enzymatic transformations...
September 18, 2017: Organic Letters
https://www.readbyqxmd.com/read/28888783/phytochemical-study-of-juglans-regia-l-leaves
#2
Sebastian Schwindl, Birgit Kraus, Jörg Heilmann
A methanolic extract of Juglans regia L. leaves was fractioned by various chromatographic techniques yielding a total of 40 metabolites belonging to megastigmane, tetralone, phenylpropanoid, neolignane and juglone glycosides. Ten unknown megastigmane glucoside derivatives (juglanionosides A-K, 1-10) and six unknown tetralone glucoside derivatives (juglanosides J-O, 11-16) together with 24 known compounds - among them 16 described for the first time in Juglans - were isolated. As characteristic structural feature, the previously undescribed compounds showed acylation of the sugar units with sinapic, ferulic, coumaric, benzoic or salicylic acid...
September 7, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28878036/different-metabolic-routes-for-coniferaldehyde-and-sinapaldehyde-with-cinnamyl-alcohol-dehydrogenase1-deficiency
#3
Rebecca Van Acker, Annabelle Déjardin, Sandrien Desmet, Lennart Hoengenaert, Ruben Vanholme, Kris Morreel, Francoise Laurans, Hoon Kim, Nicholas Santoro, Cliff Foster, Geert Goeminne, Frédéric Legee, Catherine Lapierre, Gilles Pilate, John Ralph, Wout A Boerjan
In search for renewable energy sources, genetic engineering is a promising strategy to improve plant cell wall composition for biofuel and bioproducts generation. Lignin is a major factor determining saccharification efficiency and is therefore a prime target. Here, lignin content and composition were modified in poplar (Populus tremula×P. alba) by specifically downregulating CINNAMYL ALCOHOL DEHYDROGENASE1 (CAD1) by a hairpin-RNA-mediated silencing approach. These transgenic lines showed no biomass penalty despite a 10% reduction in Klason lignin content and severe shifts in lignin composition...
September 6, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28873576/revalorisation-of-rapeseed-pomace-extracts-an-in-vitro-study-into-its-anti-oxidant-and-dna-protective-properties
#4
Franziska Pohl, Marie Goua, Giovanna Bermano, Wendy R Russell, Lorraine Scobbie, Patrícia Maciel, Paul Kong Thoo Lin
Rapeseed pomace (RSP) is a waste product obtained after edible oil production from Brassica napus. Analysis of ubiquitous secondary metabolites in RSP samples (two breeds, harvested in 2012/2014 respectively from North East of Scotland) and their ethanol/water (95:5) Soxhlet extracts were carried out. Soxhlet extraction of the RSP (petroleum ether followed by 95% ethanol) gave a solid extract. LC-MS/MS data of the extracts revealed several secondary metabolites, with Sinapic acid being the most abundant. Strong antioxidant activities of the Soxhlet extracts were confirmed from the results obtained in the FRAP, DPPH and ORAC assays...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28855131/preparation-and-properties-of-multifunctional-sinapic-acid-corn-bran-arabinoxylan-esters
#5
Yanli Li, Tong He, Rong Liang, Zhengzhe Luo, Yuanbo Zhu, Cheng Yang
In the present study, corn bran arabinoxylan (CAX) were modified with sinapic acid (SA) by esterification to generate sinapic acid corn bran arabinoxylan esters (SA-CAX) with various substituted degrees. The structure of SA-CAX was characterized by FT-IR, NMR and UV spectroscopy. And the antioxidant activities of SA-CAX were evaluated by scavenging the 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical, emulsion lipid oxidation test and the lipid peroxidant level test. Compared with CAX, SA-CAX exhibited superior antioxidant activities in vitro, which indicated that the attachment of SA to CAX could enhance antioxidant activities of CAX...
August 27, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28846647/sinapic-acid-affects-phenolic-and-trichothecene-profiles-of-f-culmorum-and-f-graminearum-sensu-stricto
#6
Tomasz Kulik, Kinga Stuper-Szablewska, Katarzyna Bilska, Maciej Buśko, Anna Ostrowska-Kołodziejczak, Dariusz Załuski, Juliusz Perkowski
Plant-derived compounds for reducing the mycotoxin load in food and feed have become a rapidly developing research field of importance for plant breeding efforts and in the search for natural fungicides. In this study, toxigenic strains of Fusarium culmorum and F. graminearum sensu stricto were exposed to sinapic acid on solid YES media at levels close to those reported in wheat bran. Fusaria produced phenolic acids, whose accumulation was decreased by exogenous sinapic acid. Strains exposed to the lowest doses of sinapic acid showed more efficient reduction of phenolic acid production than fungi kept at higher concentrations of this compound...
August 28, 2017: Toxins
https://www.readbyqxmd.com/read/28842926/synthesis-of-novel-octyl-sinapate-to-enhance-antioxidant-capacity-of-rapeseed-linseed-oil-mixture
#7
Aleksandra Szydłowska-Czerniak, Dobrochna Rabiej, Marek Krzemiński
BACKGROUND: Lipophilization allows on formation a new functionalized antioxidants having beneficial properties compared to natural hydrophilic phenolic acids. Therefore, this work is focused on the synthesis of lipophilic antioxidants, such as: a new octyl sinapate, octyl caffeate and octyl ferulate using the modified Fischer esterification of the selected hydroxycinnamic acids with 1-octanol. RESULTS: The lipophilic octyl sinapate was obtained for the first time with satisfactory yield (83%) after column chromatography purification...
August 26, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28821842/direct-learning-hidden-excited-state-interaction-patterns-from-ab-initio-dynamics-and-its-implication-as-alternative-molecular-mechanism-models
#8
Fang Liu, Likai Du, Dongju Zhang, Jun Gao
The excited states of polyatomic systems are rather complex, and often exhibit meta-stable dynamical behaviors. Static analysis of reaction pathway often fails to sufficiently characterize excited state motions due to their highly non-equilibrium nature. Here, we proposed a time series guided clustering algorithm to generate most relevant meta-stable patterns directly from ab initio dynamic trajectories. Based on the knowledge of these meta-stable patterns, we suggested an interpolation scheme with only a concrete and finite set of known patterns to accurately predict the ground and excited state properties of the entire dynamics trajectories, namely, the prediction with ensemble models (PEM)...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28802134/investigating-the-features-in-differential-absorbance-spectra-of-nom-associated-with-metal-ion-binding-a-comparison-of-experimental-data-and-td-dft-calculations-for-model-compounds
#9
Mingquan Yan, Xuze Han, Chenyang Zhang
In this study, seven model compounds containing typical functional groups (phenolic and carboxylic groups) present in nature organic matter (NOM) were used to ascertain the nature of the characteristic bands in differential absorbance spectra (DAS) of NOM that are induced by metal ion binding. Some similarities were found between the DAS of the examined model compounds, caffeic acid, ferulic acid, sinapic acid, terephthalic acid, isophthalic acid, esculetin and myricetin and those of NOM. The binding of Cu(II) with carboxylic group might produce two peaks, A1 and A2, while the binding of Cu(II) with phenolic group might produce all four Gaussian peaks, from A1 to A4 displayed in the DAS of NOM...
August 5, 2017: Water Research
https://www.readbyqxmd.com/read/28764091/development-of-functional-yogurt-containing-free-and-encapsulated-echium-oil-phytosterol-and-sinapic-acid
#10
Talita A Comunian, Isabela Elias Chaves, Marcelo Thomazini, Izabel Cristina Freitas Moraes, Roselayne Ferro-Furtado, Inar Alves de Castro, Carmen S Favaro-Trindade
The consumption of omega-3 fatty acids and phytosterol promotes the reduction of cholesterol and triacylglycerol levels. However, such compounds are susceptible to oxidation, which hampers their application. The objective of this work was to coencapsulate echium oil, phytosterols and sinapic acid (crosslinker/antioxidant), and incorporate the obtained microcapsules into yogurt. The microcapsules were evaluated for particle size, accelerated oxidation by Rancimat, and simulation of gastric/intestinal release...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28738603/vortex-assisted-liquid-liquid-liquid-microextraction-followed-by-high-performance-liquid-chromatography-for-the-simultaneous-determination-of-fourteen-phenolic-acids-in-honey-iced-tea-and-canned-coffee-drinks
#11
Marwan Shalash, Ahmad Makahleh, Salizawati Muhamad Salhimi, Bahruddin Saad
A vortex-assisted liquid-liquid-liquid microextraction method followed by high performance liquid chromatography-diode array detection for the determination of fourteen phenolic acids (cinnamic, m-coumaric, chlorogenic, syringic, ferulic, o-coumaric, p-coumaric, vanillic, p-hydroxybenzoic, caffeic, 2, 4-dihydroxybenzoic, sinapic, gentisic and gallic acids) in honey, iced tea and canned coffee drink samples has been developed. The separation was achieved using a Poroshell 120-EC-C18 column under a gradient elution at a flow rate of 0...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28737734/storage-of-fruits-and-vegetables-in-refrigerator-increases-their-phenolic-acids-but-decreases-the-total-phenolics-anthocyanins-and-vitamin-c-with-subsequent-loss-of-their-antioxidant-capacity
#12
Joseph H Y Galani, Jalpesh S Patel, Nilesh J Patel, Jayant G Talati
It is of paramount importance for consumers, scientists and industrialists to understand how low-temperature storage of food items affects their bioactive compounds and properties. This study evaluated the effects of cold storage on total phenolics (TP), phenolic acids profile (PA), total anthocyanins (TA), total ascorbic acid (Vit. C) and antioxidant activity (AA) of 19 fruits and vegetables, collected from local Indian markets and stored in refrigerator (4 °C) during 15 days. Content of TP was highest in dill and amaranth and decreased (up to 29...
July 24, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28732997/sonochemical-effect-of-flat-sweep-frequency-and-pulsed-ultrasound-fsfp-treatment-on-stability-of-phenolic-acids-in-a-model-system
#13
Juan Wang, Haile Ma, Zhongli Pan, Wenjuan Qu
To obtain greater knowledge on the stability of phenolic acids for the application of FSFP ultrasound technique in the extraction, the sonochemical effects of ultrasonic factors were investigated. The kinetic model and mechanism of degradation reaction were developed and identified by FT-IR and HPLC-ESIMS. The results showed that caffeic and sinapic acids were degraded under FSFP ultrasound treatment. The ultrasonic temperature, frequency, sweep range, sweep cycle, and pulse ratio were proved to be important factors in affecting the degradation rates of caffeic and sinapic acids...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28718636/long-chain-alkyl-esters-of-hydroxycinnamic-acids-as-promising-anticancer-agents-selective-induction-of-apoptosis-in-cancer-cells
#14
José C J M D S Menezes, Najmeh Edraki, Shrivallabh P Kamat, Mahsima Khoshneviszadeh, Zahra Kayani, Hossein Hadavand Mirzaei, Ramin Miri, Nasrollah Erfani, Maryam Nejati, José A S Cavaleiro, Tiago Silva, Luciano Saso, Fernanda Borges, Omidreza Firuzi
Cancer is the major cause of morbidity and mortality worldwide. Hydroxycinnamic acids (HCAs) are naturally occurring compounds and their alkyl esters may possess enhanced biological activities. We evaluated C4, C14, C16, and C18 alkyl esters of p-coumaric, ferulic, sinapic, and caffeic acids (19 compounds) for their cytotoxic activity against four human cancer cells and also examined their effect on cell cycle alteration and apoptosis induction. The tetradecyl (1c) and hexadecyl (1d) esters of p-coumaric acid and tetradecyl ester of caffeic acid (4c), but not the parental HCAs, were selectively effective against MOLT-4 (human lymphoblastic leukemia) cells with IC50 values of 0...
August 23, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28714341/identification-of-phenolic-compounds-from-the-leaf-part-of-teucrium-pseudo-scorodonia-desf-collected-from-algeria
#15
Karima Belarbi, Fawzia Atik-Bekkara, Imad Abdelhamid El Haci, Ilhem Bensaid, Chahrazed Bekhechi
In the present paper,we reported for the first time, the identification of the phenolic compounds in butanolic fraction obtained from the leaf part of Teucrium pseudo-Scorodonia Desf. collected from Algeria using RP-HPLC-PDA (Reversed Phase High Performance Liquid Chromatography/Photo Diode Array) technique. Several standards were used for this purpose. The analysis led to the identification of six phenolic acids (ferulic, sinapic, rosmarinic, syringique, caffeic, p-coumaric acids) and one flavonoid (rutin), the last one, has interesting pharmacological properties...
July 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28697384/schizosaccharomyces-pombe-and-saccharomyces-cerevisiae-yeasts-in-sequential-fermentations-effect-on-phenolic-acids-of-fermented-kei-apple-dovyalis-caffra-l-juice
#16
P P Minnaar, N P Jolly, V Paulsen, H W Du Plessis, M Van Der Rijst
Kei-apple (Dovyalis caffra) is an evergreen tree indigenous to Southern Africa. The fruit contains high concentrations of l-malic acid, ascorbic acid, and phenolic acids. Kei-apple juice was sequentially inoculated with Schizosaccharomyces pombe and Saccharomyces cerevisiae yeasts. A reference fermentation using only S. cerevisiae was included. The fermentation was monitored by recording mass loss. At the end of fermentation, twelve untrained judges conducted free choice aroma profiling on the fruit wines. The Kei-apple juice and wines were analysed for total titratable acidity, total soluble solids, pH, alcohol, l-malic acid, and phenolic acids...
July 6, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28692293/spectroscopic-properties-and-conformational-analysis-of-methyl-ester-of-sinapic-acid-in-various-environments
#17
B Smyk, G Mędza, A Kasparek, M Pyrka, I Gryczynski, M Maciejczyk
A methyl ester of sinapic acid (MESA) has recently attracted attention due to its antioxidant action. This article presents results of a study on the spectral and physicochemical properties of MESA, using quantum chemistry (QC), steady-state (absorption and fluorescence), and time-resolved fluorescence techniques (TCSPC). The pKa of the phenol group in the ground state was determined (8.6). The pKa* values in the excited state calculated from the Förster cycle (1.9) and from fluorescence spectra (8.5) differed significantly but the experimental data suggested that the first was the more probable one...
July 25, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28686978/sinapic-acid-modulates-nrf2-ho-1-signaling-pathway-in-cisplatin-induced-nephrotoxicity-in-rats
#18
Mushtaq Ahmad Ansari
BACKGROUND: Cisplatin-induced nephrotoxicity is related to increased reactive oxygen species and inflammatory cytokines in the kidney. Sinapic acid (SA) has both antioxidant and anti-inflammatory activities. AIMS: We determined the effects of SA on cisplatin-induced nephrotoxicity in rats, and the potential mechanisms by which it augments antioxidant responses and attenuates nephrotoxicity related to oxidative/nitrosative stress, apoptosis, and inflammation. METHODS: Kidney function markers (i...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28587634/sinapic-acid-or-its-derivatives-interfere-with-abscisic-acid-homeostasis-during-arabidopsis-thaliana-seed-germination
#19
Baodi Bi, Jingliang Tang, Shuang Han, Jinggong Guo, Yuchen Miao
BACKGROUND: Sinapic acid and its esters have broad functions in different stages of seed germination and plant development and are thought to play a role in protecting against ultraviolet irradiation. To better understand the interactions between sinapic acid esters and seed germination processes in response to various stresses, we analyzed the role of the plant hormone abscisic acid (ABA) in the regulation of sinapic acid esters involved in seed germination and early seedling growth...
June 6, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28534439/hypolipidemic-and-hepatoprotective-activities-of-rosemary-and-thyme-in-gentamicin-treated-rats
#20
A M Hegazy, A S Abdel-Azeem, H M Zeidan, K S Ibrahim, Em El Sayed
Rosemary ( Rosmarinus officinalis; RM) and thyme ( Thymus vulgaris; TV) are used as remedies. We designed this work to investigate the preventive effect of aqueous extracts of RM or TV on the gentamicin (GM)-induced hepatotoxicity and abnormalities of lipid profile in rats. Both plant extracts exhibited an in vitro antioxidant activity as determined by the 1,1-diphenyl-2-picrylhydrazyl assay. Radical scavenging activity for TV extract was 48.7% and for RM extract was 25.6%. Polyphenolic determination by high-performance liquid chromatography for both extracts revealed that catechin, coumarin, cinnamic acid and rutin were detected in both extracts...
January 1, 2017: Human & Experimental Toxicology
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