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https://www.readbyqxmd.com/read/28816398/optical-properties-of-mice-s-stool-in-550-1000-nm-wavelength-range
#1
Helene Isler, Catherine Germanier, Linda Ahnen, Jingjing Jiang, Scott Lindner, Aldo Di Costanzo Mata, Tanja Karen, Salvador Sánchez Majos, Martin Wolf, Alexander Kalyanov
The aim of this work was to measure optical properties of stool of mice to provide this relevant wavelength-dependent behavior for optical imaging modalities such as fluorescent molecular tomography and near-infrared optical tomography. BALB/c nude female mice were studied and optical properties of the stool were determined by employing the inverse adding-doubling approach. The animals were kept on chlorophyll-free diet. Nine stool samples were measured. The wavelength-dependent behavior of absorption and scattering in 550-1000 nm range is presented...
August 17, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28815240/-research-on-physical-and-mechanical-properties-crown-accuracy-by-using-self-made-fus-invest-dental-investment
#2
Jin-Shuang Wu, He-Lin Xing, Chao-Fang Dong, Tian-Wen Guo, Se-Fei Yang
PURPOSE: To evaluate the physical and mechanical properties of pure titanium castings cast by self- made FUS-invest dental investment, and evaluate casting accuracy. METHODS: Seven pure titanium castings were cast by self-made FUS-invest zirconium investment and analyzed using servo hydraulic dynamic experiment system (JJG139-83 standard), scanning electron microscope and energy spectrum analysis. Thirty-eight crowns of pure titanium were cast by two different methods...
April 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28815237/induced-polarization-restricts-the-conformational-distribution-of-a-light-harvesting-molecular-triad-in-the-ground-state
#3
Oleg N Starovoytov, Pengzhi Zhang, Piotr Cieplak, Margaret S Cheung
The light-harvesting molecular triad consisting of carotenoid polyene (C), diaryl-porphyrin (P) and pyrrole-fullerene (C60) is a donor-acceptor molecule capable of absorbing incident light in the visible range. Its ability to convert solar energy to electrical excitation and charge separation energy suggests a great potential in real-world applications. The ensemble of its conformations under ambient conditions varies widely according to its electronic state. In previous work, we applied a non-polarizable model to study the conformational distribution of the molecular triad in the ground and charge separated states...
August 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28814513/escape-of-tick-borne-flavivirus-from-2-c-methylated-nucleoside-antivirals-is-mediated-by-a-single-conservative-mutation-in-ns5-that-has-a-dramatic-effect-on-viral-fitness
#4
Ludek Eyer, Hirofumi Kondo, Darina Zouharova, Minato Hirano, James J Valdés, Memi Muto, Tomas Kastl, Shintaro Kobayashi, Jan Haviernik, Manabu Igarashi, Hiroaki Kariwa, Marketa Vaculovicova, Jiri Cerny, Rene Kizek, Andrea Kröger, Stefan Lienenklaus, Milan Dejmek, Radim Nencka, Martin Palus, Jiri Salat, Erik De Clercq, Kentaro Yoshii, Daniel Ruzek
Tick-borne encephalitis virus (TBEV) causes a severe and potentially fatal neuroinfection in humans. Despite its high medical relevance, no specific antiviral therapy is currently available. Here we demonstrate that treatment with a nucleoside analog, 7-deaza-2' -C-methyladenosine (7-deaza-2' -CMA), substantially improved disease outcome, increased survival, and reduced signs of neuroinfection and viral titers in the brains of mice infected with a lethal dose of TBEV. To investigate the mechanism of action of 7-deaza-2' -CMA, two drug-resistant TBEV clones were generated and characterized...
August 16, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28814042/portable-haptic-device-for-lower-limb-amputee-gait-feedback-assessing-static-and-dynamic-perceptibility
#5
M A B Husman, H F Maqbool, M I Awad, A A Dehghani-Sanij
Loss of joints and severed sensory pathway cause reduced mobility capabilities in lower limb amputees. Although prosthetic devices attempt to restore normal mobility functions, lack of awareness and control of limb placement increase the risk of falling and causing amputee to have high level of visual dependency. Haptic feedback can serve as a cue for gait events during ambulation thus providing sense of awareness of the limb position. This paper presents a wireless wearable skin stretch haptic device to be fitted around the thigh region...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813680/antibiotics-disrupt-coordination-between-transcriptional-and-phenotypic-stress-responses-in-pathogenic-bacteria
#6
Paul A Jensen, Zeyu Zhu, Tim van Opijnen
Bacterial genes that change in expression upon environmental disturbance have commonly been seen as those that must also phenotypically matter. However, several studies suggest that differentially expressed genes are rarely phenotypically important. We demonstrate, for Gram-positive and Gram-negative bacteria, that these seemingly uncoordinated gene sets are involved in responses that can be linked through topological network analysis. However, the level of coordination is stress dependent. While a well-coordinated response is triggered in response to nutrient stress, antibiotics trigger an uncoordinated response in which transcriptionally and phenotypically important genes are neither linked spatially nor in their magnitude...
August 15, 2017: Cell Reports
https://www.readbyqxmd.com/read/28812540/quantifying-transmission
#7
Mark Woolhouse
Transmissibility is the defining characteristic of infectious diseases. Quantifying transmission matters for understanding infectious disease epidemiology and designing evidence-based disease control programs. Tracing individual transmission events can be achieved by epidemiological investigation coupled with pathogen typing or genome sequencing. Individual infectiousness can be estimated by measuring pathogen loads, but few studies have directly estimated the ability of infected hosts to transmit to uninfected hosts...
July 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28812080/computational-design-of-ph-switchable-control-agents-for-nitroxide-mediated-polymerization
#8
Ganna Gryn'ova, Leesa M Smith, Michelle L Coote
In the present work we use accurate quantum chemistry to evaluate several known and novel nitroxides bearing acid-base groups as pH-switchable control agents for room temperature NMP. Based on G3(MP2,CC)(+)//M06-2X/6-31+G(d) calculations with UAKS-CPCM/M06-2X/6-31+G(d) solvation corrections, a number of novel nitroxides are predicted to be suitable for controlled polymerization of bulk styrene at room temperature when deprotonated (i.e. negatively charged), while remaining inert when neutral. These include an α-ethyl analogue of 3-carboxy-PROXYL and novel derivatives of 2,2,5-trimethyl-4-phenyl-3-azahexane-3-nitroxide (TIPNO) that have been modified to include acidic groups...
August 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28811662/fractal-properties-of-shoreline-changes-on-a-storm-exposed-island
#9
Xiaojing Zhong, Peng Yu, Shenliang Chen
Extreme storm events and their consequent shoreline changes are of great importance for understanding coastal evolution and assessing storm hazards. This work investigates the fractal properties of the spatial distributions of shoreline changes caused by storms. Wavelet analysis and upper-truncated power law (UTPL) fitting are used to study the power spectra of shoreline changes and to evaluate the upper limits of the cross-shore erosion and accretion. During a period affected by storms, the alongshore shoreline change patterns are strong on the 15 km scale but are weak with lower spectral power on the 20 km scale...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810908/relative-risk-estimation-of-dengue-disease-at-small-spatial-scale
#10
Daniel Adyro Martínez-Bello, Antonio López-Quílez, Alexander Torres Prieto
BACKGROUND: Dengue is a high incidence arboviral disease in tropical countries around the world. Colombia is an endemic country due to the favourable environmental conditions for vector survival and spread. Dengue surveillance in Colombia is based in passive notification of cases, supporting monitoring, prediction, risk factor identification and intervention measures. Even though the surveillance network works adequately, disease mapping techniques currently developed and employed for many health problems are not widely applied...
August 15, 2017: International Journal of Health Geographics
https://www.readbyqxmd.com/read/28810799/spin-dependent-charge-recombination-along-para-phenylene-molecular-wires
#11
Thomas P Fay, Alan M Lewis, David E Manolopoulos
We have used an efficient new quantum mechanical method for radical pair recombination reactions to study the spin-dependent charge recombination along PTZ(•+)-Phn-PDI(•-) molecular wires. By comparing our results with the experimental data of Weiss et al. [J. Am. Chem. Soc. 126, 5577 (2004)], we are able to extract the spin-dependent (singlet and triplet) charge recombination rate constants for wires with n = 2-5. These spin-dependent rate constants have not been extracted previously from the experimental data because they require fitting its magnetic field-dependence to the results of quantum spin dynamics simulations...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28810438/patients-with-limited-communication-in-end-of-life-situations-initial-psychometric-properties-of-a-discomfort-observation-scale
#12
Ana Lucila Soto-Rubio, José Manuel Tomás Miguel, Marián Pérez-Marín, Pilar Barreto Martín
This work presents an observational scale which takes into account different observable indicators of discomfort of patients in end-of-life situations with difficulties in communicating due to cognitive impairment, fatigue or sedation and provides details of its validation. In all, 71 adults participated. Model fit was adequate ( χ(2)(27) = 43.28, p = .024, comparative fit index = .975, root mean square error of approximation = .092 and confidence interval 90% (.033-.140)). Alpha coefficient was ...
March 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28808688/adaptive-mistranslation-accelerates-the-evolution-of-fluconazole-resistance-and-induces-major-genomic-and-gene-expression-alterations-in-candida-albicans
#13
Tobias Weil, Rodrigo Santamaría, Wanseon Lee, Johan Rung, Noemi Tocci, Darren Abbey, Ana R Bezerra, Laura Carreto, Gabriela R Moura, Mónica Bayés, Ivo G Gut, Attila Csikasz-Nagy, Duccio Cavalieri, Judith Berman, Manuel A S Santos
Regulated erroneous protein translation (adaptive mistranslation) increases proteome diversity and produces advantageous phenotypic variability in the human pathogen Candida albicans. It also increases fitness in the presence of fluconazole, but the underlying molecular mechanism is not understood. To address this question, we evolved hypermistranslating and wild-type strains in the absence and presence of fluconazole and compared their fluconazole tolerance and resistance trajectories during evolution. The data show that mistranslation increases tolerance and accelerates the acquisition of resistance to fluconazole...
July 2017: MSphere
https://www.readbyqxmd.com/read/28807686/adsorption-of-zn-ii-ions-by-chitosan-coated-diatomaceous-earth
#14
Suhaib S Salih, Tushar K Ghosh
In this work, chitosan coated diatomaceous earth (CCDE) beads were synthesized by a drop-wise method and characterized by FTIR, BET, SEM, EDS, and zeta potential for Zn(II) ion removal from aqueous solution in batch and continuous processes. Several parameters have been studied such as solution-pH, initial Zn(II) ion concentration, temperature, flow rate, and contact time to investigate the Zn(II) ion uptake. The maximum adsorption capacity of Zn(II) ion onto CCDE beads was 127.4mg/g in batch studies. The adsorption followed Pseudo second order and was well fitted to Langmuir model, indicating monolayer adsorption behavior...
August 11, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28806568/a-simple-high-performance-liquid-chromatography-mass-spectrometry-method-for-therapeutic-drug-monitoring-of-isavuconazole-and-four-other-antifungal-drugs-in-human-plasma-samples
#15
Giovanna Fatiguso, Fabio Favata, Ilaria Zedda, Amedeo De Nicolò, Jessica Cusato, Valeria Avataneo, Giovanni Di Perri, Antonio D'Avolio
Triazoles chanced the prevention and treatment of invasive fungal infections, but their pharmacokinetic properties are still unclear. In particular, isavuconazole (ISC) is a new broad-spectrum antifungal triazole approved in 2015 as first-line treatment for intravenous and oral use against invasive aspergillosis and for mucormycosis. Nowadays, the optimal management of the treatments with triazoles requires the use of Therapeutic Drug Monitoring (TDM), in order to prevent sub-therapeutic or toxic concentrations...
August 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28806210/risk-stratification-for-major-postoperative-complications-in-patients-undergoing-intra-abdominal-general-surgery-using-latent-class-analysis
#16
Minjae Kim, Melanie M Wall, Guohua Li
BACKGROUND: Preoperative risk stratification is a critical element in assessing the risks and benefits of surgery. Prior work has demonstrated that intra-abdominal general surgery patients can be classified based on their comorbidities and risk factors using latent class analysis (LCA), a model-based clustering technique designed to find groups of patients that are similar with respect to characteristics entered into the model. Moreover, the latent risk classes were predictive of 30-day mortality...
August 10, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28806193/speech-perception-in-noise-and-listening-effort-of-older-adults-with-nonlinear-frequency-compression-hearing-aids
#17
James Shehorn, Nicole Marrone, Thomas Muller
OBJECTIVES: The purpose of this laboratory-based study was to compare the efficacy of two hearing aid fittings with and without nonlinear frequency compression, implemented within commercially available hearing aids. Previous research regarding the utility of nonlinear frequency compression has revealed conflicting results for speech recognition, marked by high individual variability. Individual differences in auditory function and cognitive abilities, specifically hearing loss slope and working memory, may contribute to aided performance...
August 10, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28805926/multiple-trait-genomewide-mapping-and-gene-network-analysis-for-scrotal-circumference-growth-curves-in-brahman-cattle
#18
A C C Soares, S E F Guimarães, M J Kelly, M R S Fortes, F F E Silva, L L Verardo, R Mota, S Moore
Fertility traits are economically important in cattle breeding programs. Scrotal circumference (SC) measures are repeatable, easily obtained, highly heritable, and positively correlated with female fertility traits and sperm quality traits in males. A useful approach to summarize SC measures over time is using nonlinear models, which summarize specific measures of SC in a few parameters with biological interpretation. This approach facilitates the selection of bulls with larger SC and maturity index (K), that is, early maturing animals...
August 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28805250/peer-review-the-future-is-here
#19
Maria Papatriantafyllou
Several divergent standpoints are hosted under the umbrella of Peer Review. Authors, who wish to see the results of scrupulous work published, in the anticipation of career promotion or secure funding. Editors, who are under pressure to identify sound and novel research. Reviewers, who try to fit a thoughtful and time-consuming process within busy schedules, often receiving no credit for it. And Publishers competing in a transforming landscape of fast and abundant science publishing. This article is protected by copyright...
August 14, 2017: FEBS Letters
https://www.readbyqxmd.com/read/28804918/low-rank-approximation-methods-for-mr-fingerprinting-with-large-scale-dictionaries
#20
Mingrui Yang, Dan Ma, Yun Jiang, Jesse Hamilton, Nicole Seiberlich, Mark A Griswold, Debra McGivney
PURPOSE: This work proposes new low rank approximation approaches with significant memory savings for large scale MR fingerprinting (MRF) problems. THEORY AND METHODS: We introduce a compressed MRF with randomized singular value decomposition method to significantly reduce the memory requirement for calculating a low rank approximation of large sized MRF dictionaries. We further relax this requirement by exploiting the structures of MRF dictionaries in the randomized singular value decomposition space and fitting them to low-degree polynomials to generate high resolution MRF parameter maps...
August 13, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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