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https://www.readbyqxmd.com/read/28324780/the-longitudinal-relationship-between-control-over-working-hours-and-depressive-symptoms-results-from-slosh-a-population-based-cohort-study
#1
Sophie C Albrecht, Göran Kecklund, Kristiina Rajaleid, Constanze Leineweber
BACKGROUND: Psychosocial work factors can affect depressive moods, but research is inconclusive if flexibility to self-determine working hours (work-time control, WTC) is associated with depressive symptoms over time. We investigated if either sub-dimension of WTC, control over daily hours and control over time off, was related to depressive symptoms over time and examined causal, reversed-causal, and reciprocal pathways. METHODS: The study was based on four waves of the Swedish Longitudinal Occupational Survey of Health which is a follow-up of representative samples of the Swedish working population...
March 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28324326/the-impact-of-fabry-disease-on-reproductive-fitness
#2
Dawn A Laney, Virginia Clarke, Allison Foley, Eric W Hall, Scott E Gillespie, Myrl Holida, Morgan Simmons, Alexandrea Wadley
Fabry disease (FD) is a pan-ethnic, X-linked, progressive lysosomal storage disorder caused by pathogenic mutations in the GLA gene. Published case reports and abstracts suggest that decreased reproductive fitness may occur in males with FD. In order to understand the impact of FD on reproductive fitness and increase the accuracy of reproductive genetic counseling, this study examines a large, multi-centered population of individuals with FD to determine if males have reduced reproductive fitness. Study data were collected on 376 patients through two, gender-specific surveys distributed across the United States and Canada...
March 22, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28324187/frontal-burr-hole-approach-for-neuroendoscopic-resection-of-craniopharyngioma-with-the-nico-myriad-device-report-of-two-cases
#3
Reilin J Moore, Andrea Scherer, Daniel H Fulkerson
OBJECTIVE: Craniopharyngiomas are challenging tumors to resect due to their deep location and proximity to vital structures. The perceived benefit of gross total resection may be tempered by the possibility of permanent disability. Minimally invasive techniques may reduce surgical morbidity while still allowing effective resection. The authors describe their initial experience with a neuroendoscopic transcortical, transventricular approach to two craniopharyngiomas. The surgeries were performed through a right frontal burr hole using the NICO Myriad, a side-cutting, aspiration device that fits through the working channel of a standard neuroendoscope...
March 21, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28319864/enantioselective-degradation-of-alpha-cypermethrin-and-detection-of-its-metabolites-in-bullfrog-rana-catesbeiana
#4
Guojun Yao, Xu Jing, Chang Liu, Peng Wang, Xueke Liu, Yinzhu Hou, ZhiQiang Zhou, Donghui Liu
Bullfrog, as a kind of amphibians, can be easily exposed to varied pollutants in the environment for the reason of its habitats and highly permeable skin. We investigated the degradation kinetics and residues of α-cypermethrin in bullfrog by two different methods of administration for the environmental monitoring the behavior of one of the most used pesticides in the amphibians. The oral administration and water exposure of α-cypermethrin on bullfrog was studied in this work. α-Cypermethrin and its main metabolites of cis-3-(2',2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (cis-DCCA) and 3-phenoxybenzoic acid (3-PBA), which have been determined that having correlation with a number of epidemic diseases, were detected simultaneously...
March 17, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28318824/a-kinetic-approach-on-hexavalent-chromium-removal-with-metallic-iron
#5
M Gheju, I Balcu, A Enache, A Flueras
This paper examines the mechanism of Cr(VI) removal with Fe(0), and the possible effect of various experimental parameters, from a kinetic perspective. The experimental data was analyzed using five different kinetic models: three for chemical reactions and two for adsorption processes. It was found that the process fitted well to the zero-order kinetic model for all investigated systems, excepting experiments conducted at 6 °C and those with nano-Fe(0), when the process followed the Ho's pseudo second-order model...
March 16, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28318258/molecular-dynamics-studies-on-liquid-vapor-interface-properties-and-structures-of-1-ethyl-3-methylimidazolium-dimethylphosphate-water
#6
Tianyu Li, Zongchang Zhao, Xiaodong Zhang, Xican Sun
1-ethyl-3-methylimidazolium dimethylphosphate ([Emim][Dmp])-water binary solution is one of the promising new working-pairs for absorption heat pump and absorption chillers, which are widely used to recover industrial waste heat. In the absorption process, the mass and heat transfer at the interface greatly depend on interface microscopes structure. Therefore, in order to understand the absorption process, it is very important to study the interface microscopes structure. The liquid-vapor interface properties, as well as the orientation of [Emim]+, [Dmp]-, water at the interface and its aqueous solution with different water mole fraction, were studied using classical all-atom force field by molecular dynamic simulations...
March 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28316280/predicting-fitness-to-practise-events-in-international-medical-graduates-who-registered-as-uk-doctors-via-the-professional-and-linguistic-assessments-board-plab-system-a-national-cohort-study
#7
Paul A Tiffin, Lewis W Paton, Lazaro M Mwandigha, John C McLachlan, Jan Illing
BACKGROUND: International medical graduates working in the UK are more likely to be censured in relation to fitness to practise compared to home graduates. Performance on the General Medical Council's (GMC's) Professional and Linguistic Assessments Board (PLAB) tests and English fluency have previously been shown to predict later educational performance in this group of doctors. It is unknown whether the PLAB system is also a valid predictor of unprofessional behaviour and malpractice...
March 20, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28315995/ligand-based-virtual-screening-under-partial-shape-constraints
#8
Mathias M von Behren, Matthias Rarey
Ligand-based virtual screening has proven to be a viable technology during the search for new lead structures in drug discovery. Despite the rapidly increasing number of published methods, meaningful shape matching as well as ligand and target flexibility still remain open challenges. In this work, we analyze the influence of knowledge-based sterical constraints on the performance of the recently published ligand-based virtual screening method mRAISE. We introduce the concept of partial shape matching enabling a more differentiated view on chemical structure...
March 18, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28315837/a-search-for-genes-mediating-the-growth-promoting-function-of-tgf%C3%AE-in-the-drosophila-melanogaster-wing-disc
#9
Covadonga F Hevia, Ana López-Varea, Nuria Esteban, Jose F de Celis
TGFβ signalling has a complex influence in cell proliferation, acting to stop cell division in differentiating cells, but also promoting cell division in immature cells. The activity of the pathway in Drosophila is mostly required to stimulate the proliferation of neural and epithelial tissues. Most interestingly, this function is not absolutely required for cell division, but it is needed for these tissues to reach their correct size. It is not known how TGFβ signalling promotes cell division in imaginal discs, or what are the interactions between TGFβ activity and other signalling pathways regulating cell proliferation...
March 17, 2017: Genetics
https://www.readbyqxmd.com/read/28314188/pharmaceutical-analysis-of-a-novel-propargyl-linked-antifolate-antibiotic-in-the-mouse
#10
John Hoody, Jeremy B Alverson, Santosh Keshipeddy, Patrick A Barney, Larissa Walker, Amy C Anderson, Dennis L Wright, Nigel D Priestley
Antimicrobial resistance to current antibiotics is a significant public health problem and the need for new antibiotics is a compelling one. We have been developing a new series of antibiotics, propargyl-linked diaminopyrimidines, based on the structure of trimethoprim. To date we have discovered compounds that are effective inhibitors of dihydrofolate reductase (the target of trimethoprim), that are potent antibiotics in vitro against a range of Gram-positive pathogens including methicillin-resistant S. aureus, and that are non-toxic in mammalian cell culture...
March 6, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28314165/exploring-the-use-of-routine-outcome-monitoring-in-the-treatment-of-patients-with-a-psychotic-disorder
#11
M Tasma, E J Liemburg, H Knegtering, P A E G Delespaul, A Boonstra, S Castelein
BACKGROUND: Routine Outcome Monitoring (ROM) has become part of the treatment process in mental health care. However, studies have indicated that few clinicians in psychiatry use the outcome of ROM in their daily work. The aim of this study was to explore the degree of ROM use in clinical practice as well as the explanatory factors of this use. METHODS: In the Northern Netherlands, a ROM-protocol (ROM-Phamous) for patients with a psychotic disorder has been implemented...
December 28, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28303590/psychiatric-disability-in-law-enforcement-officers
#12
Marilyn Price
Law enforcement officers all across the world are exposed to violence, confrontation, and traumatic incidents. They regularly witness death and suffering and are at risk of personal injury. Psychiatric sequelae include an increased risk for trauma-related symptoms, depression, alcohol-use disorders, and stress-related medical conditions. Law enforcement officers have been applying for early disability retirement pensions at an increased rate for stress-related psychiatric and medical conditions. As a result, law enforcement agencies are prematurely losing valuable resources, officers with training and experience...
March 17, 2017: Behavioral Sciences & the Law
https://www.readbyqxmd.com/read/28303531/comprehensive-analysis-of-mile-gene-expression-data-set-advances-discovery-of-leukaemia-type-and-subtype-biomarkers
#13
Wojciech Labaj, Anna Papiez, Andrzej Polanski, Joanna Polanska
Large collections of data in studies on cancer such as leukaemia provoke the necessity of applying tailored analysis algorithms to ensure supreme information extraction. In this work, a custom-fit pipeline is demonstrated for thorough investigation of the voluminous MILE gene expression data set. Three analyses are accomplished, each for gaining a deeper understanding of the processes underlying leukaemia types and subtypes. First, the main disease groups are tested for differential expression against the healthy control as in a standard case-control study...
March 16, 2017: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/28303173/validating-an-agency-based-tool-for-measuring-women-s-empowerment-in-a-complex-public-health-trial-in-rural-nepal
#14
Lu Gram, Joanna Morrison, Neha Sharma, Bhim Shrestha, Dharma Manandhar, Anthony Costello, Naomi Saville, Jolene Skordis-Worrall
Despite the rising popularity of indicators of women's empowerment in global development programmes, little work has been done on the validity of existing measures of such a complex concept. We present a mixed methods validation of the use of the Relative Autonomy Index for measuring Amartya Sen's notion of agency freedom in rural Nepal. Analysis of think-aloud interviews (n = 7) indicated adequate respondent understanding of questionnaire items, but multiple problems of interpretation including difficulties with the four-point Likert scale, questionnaire item ambiguity and difficulties with translation...
January 2, 2017: Journal of Human Development and Capabilities
https://www.readbyqxmd.com/read/28302927/workplace-incivility-in-japan-reliability-and-validity-of-the-japanese-version-of-the-modified-work-incivility-scale
#15
Kanami Tsuno, Norito Kawakami, Akihito Shimazu, Kyoko Shimada, Akiomi Inoue, Michael P Leiter
OBJECTIVES: Although incivility is a common interpersonal mistreatment and associated with poor mental health, there are few studies about it in Asian countries. The aim of this study was to develop the Japanese version of the modified Work Incivility Scale (J-MWIS), investigate its reliability and validity, and reveal the prevalence of incivility among Japanese employees in comparison with data on Canadian employees. METHODS: A total of 2,191 Japanese and 1,071 Canadian employees were surveyed, using either the J-MWIS or MWIS...
March 9, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/28301436/the-effects-of-recovery-duration-during-high-intensity-interval-exercise-on-time-spent-at-high-rates-of-oxygen-consumption-oxygen-kinetics-and-blood-lactate
#16
Ilias Smilios, Aristides Myrkos, Andreas Zafeiridis, Argyris Toubekis, Apostolos Spassis, Savas P Tokmakidis
The recovery duration and the work to recovery ratio are important aspects to consider when designing a high-intensity aerobic interval exercise (HIIE). This study examined the effects of recovery duration on total exercise time performed above 80, 90 and 95% of maximum oxygen consumption (VO2max) and heart rate (HRmax) during a single-bout HIIE. We also evaluated the effects on VO2 and HR kinetics, blood lactate concentration and rating of perceived exertion (RPE). Eleven moderately trained males (22.1±1 yrs...
March 13, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28301086/b1-mapping-for-bias-correction-in-quantitative-t1-imaging-of-the-brain-at-3t-using-standard-pulse-sequences
#17
Mathieu Boudreau, Christine L Tardif, Nikola Stikov, John G Sled, Wayne Lee, G Bruce Pike
PURPOSE: B1 mapping is important for many quantitative imaging protocols, particularly those that include whole-brain T1 mapping using the variable flip angle (VFA) technique. However, B1 mapping sequences are not typically available on many magnetic resonance imaging (MRI) scanners. The aim of this work was to demonstrate that B1 mapping implemented using standard scanner product pulse sequences can produce B1 (and VFA T1 ) maps comparable in quality and acquisition time to advanced techniques...
March 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28298129/a-rural-shelter-in-ontario-adapting-to-address-the-changing-needs-of-women-who-have-experienced-intimate-partner-violence-a-qualitative-case-study
#18
Tara Mantler, Barat Wolfe
INTRODUCTION: Intimate partner violence is a significant public health problem, with shelters offering the predominant community-based solution. Shelters in Canada are mandated to provide a safe place, protection planning, advocacy and counseling among other services. Recently it has been noted the role of the shelter was shifting from an inpatient to outpatient model with a focus on increased integration of health and social services. This changing role of the shelter is amplified within the rural context where resources and cultural norms may be limited or incompatible with help-seeking behaviors...
January 2017: Rural and Remote Health
https://www.readbyqxmd.com/read/28297898/particle-morphology-effects-in-random-sequential-adsorption
#19
Lj Budinski-Petković, I Lončarević, D Dujak, A Karač, J R Šćepanović, Z M Jakšić, S B Vrhovac
The properties of the random sequential adsorption of objects of various shapes on a two-dimensional triangular lattice are studied numerically by means of Monte Carlo simulations. The depositing objects are formed by self-avoiding lattice steps, whereby the size of the objects is gradually increased by wrapping the walks in several different ways. The aim of this work is to investigate the impact of the geometrical properties of the shapes on the jamming density θ_{J} and on the temporal evolution of the coverage fraction θ(t)...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28297440/evaluation-of-the-uncertainty-in-an-ebt3-film-dosimetry-system-utilizing-net-optical-density
#20
Elsa Y León Marroquin, José A Herrera González, Miguel A Camacho López, José E Villarreal Barajas, Olivia A García-Garduño
Radiochromic film has become an important tool to verify dose distributions for intensity-modulated radiotherapy (IMRT) and quality assurance (QA) procedures. A new radiochromic film model, EBT3, has recently become available, whose composition and thickness of the sensitive layer are the same as those of previous EBT2 films. However, a matte polyester layer was added to EBT3 to prevent the formation of Newton's rings. Furthermore, the symmetrical design of EBT3 allows the user to eliminate side-orientation dependence...
September 2016: Journal of Applied Clinical Medical Physics
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