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https://www.readbyqxmd.com/read/28534848/development-and-design-of-next-generation-head-mounted-ambulatory-microdose-positron-emission-tomography-am-pet-system
#1
Samantha Melroy, Christopher Bauer, Matthew McHugh, Garret Carden, Alexander Stolin, Stan Majewski, Julie Brefczynski-Lewis, Thorsten Wuest
Several applications exist for a whole brain positron-emission tomography (PET) brain imager designed as a portable unit that can be worn on a patient's head. Enabled by improvements in detector technology, a lightweight, high performance device would allow PET brain imaging in different environments and during behavioral tasks. Such a wearable system that allows the subjects to move their heads and walk-the Ambulatory Microdose PET (AM-PET)-is currently under development. This imager will be helpful for testing subjects performing selected activities such as gestures, virtual reality activities and walking...
May 19, 2017: Sensors
https://www.readbyqxmd.com/read/28533085/return-to-drive-after-non-evolutive-brain-damage-french-recommendations
#2
REVIEW
Anne-Claire D'apolito, Jean-Luc Leguiet, Michel Enjalbert, Francis Lemoine, Jean-Michel Mazaux
Return to drive after brain damage is a crucial question either for patients than health professionals. The Société française de medicine physique et de réadaptation (SOFMER) and Comète France association developed recommandations for patient's identification, evaluation and accompaniment as part of their project to resume to drive. The place of rehabilitation process and patient's focus has been also discussed. AIMS: Using a literature review, the aim was to define clinical pathways to determine people who need a fitness to drive evaluation after a non-evolutive brain damage as well as the assessment process...
May 19, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28532031/screening-of-process-variables-to-enhance-the-solubility-of-famotidine-with-2-hydroxypropyl-%C3%AE-cyclodextrin-pvp-k-30-by-using-plackett-burman-design-approach
#3
Umakant Verma, Jitendra B Naik, Jayesh S Patil, Sunil K Yadava
In the present work, inclusion complex of famotidine (FMT) was prepared with (2-HydroxyPropyl)-β-Cyclodextrin (HP-β-CyD) and polyvinylpyrrolidone K-30 (PVP K-30) by spray drying technique to enhance the solubility of famotidine. FMT is a potent histamine H2-receptor antagonist having low solubility as well as oral bioavailability. In order to enhance the solubility of FMT, a quality by design (QbD) approach has been used by employing Plackett-Burman design (PBD). With the application of PBD, seven independent process variables were investigated and optimized for maximum solubility...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28530132/development-of-a-high-fidelity-pressurized-porcine-beating-heart-simulator-for-cardiac-surgery-training
#4
Igo B Ribeiro, Janet M C Ngu, Gurinder Gill, Fraser D Rubens
BACKGROUND: Development of a high-fidelity cardiac surgery simulator (CSS) requires integration of a heart model with a mock cardiopulmonary bypass (CPB) circuit that can provide feedback to mimic the pathophysiology of cardiac surgery. However, the cost of commercially available simulators precludes regular use. We describe steps in the construction of a high-fidelity CSS that integrates a pulsatile paracorporeal ventricular-assist device (Pulse-VAD) and a commercially available CPB simulator...
May 1, 2017: Perfusion
https://www.readbyqxmd.com/read/28529544/complementary-and-alternative-interventions-for-fatigue-management-after-traumatic-brain-injury-a-systematic-review
#5
Gang-Zhu Xu, Yan-Feng Li, Mao-De Wang, Dong-Yuan Cao
BACKGROUND: We systematically reviewed randomized controlled trials (RCTs) of complementary and alternative interventions for fatigue after traumatic brain injury (TBI). METHODS: We searched multiple online sources including ClinicalTrials.gov, the Cochrane Library database, MEDLINE, CINAHL, Embase, the Web of Science, AMED, PsychINFO, Toxline, ProQuest Digital Dissertations, PEDro, PsycBite, and the World Health Organization (WHO) trial registry, in addition to hand searching of grey literature...
May 2017: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/28529156/transgenerational-effects-of-maternal-and-grandmaternal-age-on-offspring-viability-and-performance-in-drosophila-melanogaster
#6
Margaret C Bloch Qazi, Paige B Miller, Penny M Poeschel, Mai H Phan, Joseph L Thayer, Christian L Medrano
In non-social insects, fitness is determined by relative lifetime fertility. Fertility generally declines with age as a part of senescence. For females, senescence has profound effects on fitness by decreasing viability and fertility as well as those of her offspring. However, important aspects of these maternal effects, including the cause(s) of reduced offspring performance and carry-over effects of maternal age, are poorly understood. Drosophila melanogaster is a useful system for examining potential transgenerational effects of increasing maternal age, because of their use as a model system for studying the physiology and genetic architecture of both reproduction and senescence...
May 18, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28527193/comparison-of-digital-intraoral-scanners-by-single-image-capture-system-and-full-color-movie-system
#7
Meguru Yamamoto, Yu Kataoka, Atsufumi Manabe
BACKGROUND: The use of dental computer-aided design/computer-aided manufacturing (CAD/CAM) restoration is rapidly increasing. OBJECTIVE: This study was performed to evaluate the marginal and internal cement thickness and the adhesive gap of internal cavities comprising CAD/CAM materials using two digital impression acquisition methods and micro-computed tomography. METHODS: Images obtained by a single-image acquisition system (Bluecam Ver...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28526346/release-study-and-inhibitory-activity-of-thyme-essential-oil-loaded-chitosan-nanoparticles-and-nanocapsules-against-foodborne-bacteria
#8
M Sotelo-Boyás, Z Correa-Pacheco, S Bautista-Baños, Y Gómez Y Gómez
The antibacterial property of thyme essential oil due to different volatile compounds, has been well documented in the literature. To overcome the high volatility of essential oil components, encapsulation has emerged as a new alternative. In this work, chitosan and thyme essential oil-loaded chitosan nanoparticles (TEO-CSNPs) and nanocapsules (TEO-CSNCs) were prepared by nanoprecipitation and nanoencapsulation, respectively. The morphology, encapsulation efficiency, release kinetics, and inhibitory activity were evaluated...
May 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28526048/men-s-and-women-s-response-to-treatment-and-perceptions-of-outcomes-in-a-randomized-controlled-trial-of-injectable-opioid-assisted-treatment-for-severe-opioid-use-disorder
#9
Heather Palis, Kirsten Marchand, Daphne Guh, Suzanne Brissette, Kurt Lock, Scott MacDonald, Scott Harrison, Aslam H Anis, Michael Krausz, David C Marsh, Martin T Schechter, Eugenia Oviedo-Joekes
BACKGROUND: To test whether there are gender differences in treatment outcomes among patients receiving injectable opioids for the treatment of long-term opioid-dependence. The study additionally explores whether men and women have different perceptions of treatment effectiveness. METHODS: This study is a secondary analysis from SALOME, a double-blind, phase III, randomized controlled trial testing the non-inferiorirty of injectable hydromorphone to injectable diacetylmorphine among 202 long-term street opioid injectors in Vancouver (Canada)...
May 19, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/28524851/extended-fisheries-recovery-timelines-in-a-changing-environment
#10
Gregory L Britten, Michael Dowd, Lisa Kanary, Boris Worm
Rebuilding depleted fish stocks is an international policy goal and a 2020 Aichi target under the Convention on Biological Diversity. However, stock productivity may shift with future climate change, with unknown consequences for sustainable harvesting, biomass targets and recovery timelines. Here we develop a stochastic modelling framework to characterize variability in the intrinsic productivity parameter (r) and carrying capacity (K) for 276 global fish stocks worldwide. We use models of dynamic stock productivity fitted via Bayesian inference to forecast rebuilding timelines for depleted stocks...
May 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28523465/development-and-validation-of-a-cross-country-hospital-patient-quality-of-care-assessment-tool-in-europe
#11
Amanda Villiers-Tuthill, Karolina Doulougeri, Hannah McGee, Anthony Montgomery, Efharis Panagopoulou, Karen Morgan
BACKGROUND: Patient perceptions of quality of care (QoC) are directly linked with patient safety and clinical effectiveness. We need patient-designed QoC instruments that work across languages and countries to optimise studies across systems in this area. Few QoC measurement tools exist that assess all aspects of QoC from the patient perspective. This paper describes the development and validation of a comprehensive measure to assess patient perceptions of QoC that incorporates technical and interpersonal aspects of care and is grounded in the established Institute of Medicine (IOM) QoC framework...
May 18, 2017: Patient
https://www.readbyqxmd.com/read/28521219/antifouling-zwitterionic-hydrogel-coating-improves-hemocompatibility-of-activated-carbon-hemoadsorbent
#12
Nana Cai, Qingsi Li, Jiamin Zhang, Tong Xu, Weiqiang Zhao, Jing Yang, Lei Zhang
Activated carbon has been widely used in hemoperfusion treatments. However, its performance has been significantly compromised by their poor hemocompatibility. In this work, we developed a novel antifouling adsorbent based on zwitterionic poly-carboxybetaine (PCB) hydrogel and powdered activated carbon (PAC) to improve hemocompatibility. We found this new adsorbent (PCB-PAC) was highly stable with negligible leakage of activated carbon debris. It could efficiently resist protein adsorption and avoid any hemolysis effect...
April 20, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28515947/the-impact-of-body-armor-on-physical-performance-of-law-enforcement-personnel-a-systematic-review
#13
Colin Tomes, Robin Marc Orr, Rodney Pope
BACKGROUND: The law enforcement officer profession requires performance of arduous occupational tasks while carrying an external load, consisting of, at minimum, a chest rig, a communication system, weaponry, handcuffs, personal protective equipment and a torch. The aim of this systematic review of the literature was to identify and critically appraise the methodological quality of published studies that have investigated the impacts of body armour on task performance and to synthesize and report key findings from these studies to inform law enforcement organizations...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28515734/plant-growth-under-natural-light-conditions-provides-highly-flexible-short-term-acclimation-properties-toward-high-light-stress
#14
Tobias Schumann, Suman Paul, Michael Melzer, Peter Dörmann, Peter Jahns
Efficient acclimation to different growth light intensities is essential for plant fitness. So far, most studies on light acclimation have been conducted with plants grown under different constant light regimes, but more recent work indicated that acclimation to fluctuating light or field conditions may result in different physiological properties of plants. Thale cress (Arabidopsis thaliana) was grown under three different constant light intensities (LL: 25 μmol photons m(-2) s(-1); NL: 100 μmol photons m(-2) s(-)(1); HL: 500 μmol photons m(-2) s(-1)) and under natural fluctuating light (NatL) conditions...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28514190/criterion-referenced-fitness-standards-associated-with-maintaining-functional-capacity-in-chilean-older-adults
#15
Eugenio Merellano-Navarro, Daniel Collado-Mateo, Javier García-Rubio, Narcís Gusi, Pedro R Olivares
The aim of the current study was to develop fitness standards associated with maintaining physical capacity in older adults at two different levels - that needed for advanced functioning and that needed for maintaining moderate (independent) functional ability. Cross-sectional study of 406 Chilean adults aged 60 and more. Functional capacity was measured via the Composite Physical Function scale (CPF). A battery of validated fitness tests for this population was used. Based on the results of the CPF, two variables were created: "advanced physical capacity" (defined as those scoring 24 on the CPF scale) and "moderate (independent) physical capacity," defined as those scoring between 14 and 23 on the CPF scale...
May 17, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28513264/body-composition-analysis-by-using-bioelectrical-impedance-in-a-young-healthy-chinese-population-methodological-considerations
#16
Wei Chen, Hua Jiang, Jiong-Xian Yang, Hao Yang, Jing-Min Liu, Xiu-Yuan Zhen, Lian-Jun Feng, Jian-Chun Yu
OBJECTIVE: To develop a new bioelectrical impedance analysis (BIA) model for analyzing body composition by using isotope dilution, magnetic resonance imaging (MRI), and dual-energy X-ray absorptiometry (DEXA) as the reference methods in young healthy Chinese populations. METHODS: Thirty healthy participants were enrolled. Their body composition was analyzed using BIA and 3 reference methods. We established a model that uniformed data from 3 references methods (isotope, MRI, and DEXA) into 1 formula...
June 2017: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/28513207/evolutionary-developmental-robotics-improving-morphology-and-control-of-physical-robots
#17
Vuk Vujovic, Andre Rosendo, Luzius Brodbeck, Fumiya Iida
Evolutionary algorithms have previously been applied to the design of morphology and control of robots. The design space for such tasks can be very complex, which can prevent evolution from efficiently discovering fit solutions. In this article we introduce an evolutionary-developmental (evo-devo) experiment with real-world robots. It allows robots to grow their leg size to simulate ontogenetic morphological changes, and this is the first time that such an experiment has been performed in the physical world...
May 17, 2017: Artificial Life
https://www.readbyqxmd.com/read/28509562/thiolate-spin-population-of-type-i-copper-in-azurin-derived-from-33-s-hyperfine-coupling
#18
Marie Ramirez Cohen, Netanel Mendelman, Marina Radoul, Tiffany D Wilson, Masha G Savelieff, Herbert Zimmermann, Ilia Kaminker, Akiva Feintuch, Yi Lu, Daniella Goldfarb
The electron transfer mediating properties of type I copper proteins stem from the intricate ligand coordination sphere of the Cu ion in their active site. These redox properties are in part due to unusual cysteine thiol coordination, which forms a highly covalent copper-sulfur (Cu-S) bond. The structure and electronic properties of type I copper have been the subject of many experimental and theoretical studies. The measurement of spin delocalization of the Cu(II) unpaired electron to neighboring ligands provides an elegant experimental way to probe the fine details of the electronic structure of type I copper...
May 16, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28508297/adaptation-to-stochastic-temporal-variations-in-intratumoral-blood-flow-the-warburg-effect-as-a-bet-hedging-strategy
#19
Curtis A Gravenmier, Miriam Siddique, Robert A Gatenby
While most cancers promote ingrowth of host blood vessels, the resulting vascular network usually fails to develop a mature organization, resulting in abnormal vascular dynamics with stochastic variations that include slowing, cessation, and even reversal of flow. Thus, substantial spatial and temporal variations in oxygen concentration are commonly observed in most cancers. Cancer cells, like all living systems, are subject to Darwinian dynamics such that their survival and proliferation are dependent on developing optimal phenotypic adaptations to local environmental conditions...
May 15, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/28506009/structural-equation-model-of-interactions-between-risk-factors-and-work-related-musculoskeletal-complaints-among-iranian-hospital-nurses
#20
Semira Mehralizadeh, Alireza Dehdashti, Masoud Motaelebi Kashani
BACKGROUND: Statistics indicate a high risk of developing work-related musculoskeletal disorders among hospital nurses. The challenge is to understand the associations between musculoskeletal symptoms and various individual and occupational risk factors. OBJECTIVE: This study examined the direct and indirect interactions of various risk factors with musculoskeletal complaints in hospital nurses. METHOD: In a cross-sectional design, Iranian hospital nurses from Semnan University of Medical Sciences participated in a questionnaire survey reporting their perceived perceptions of various work-related risk factors and musculoskeletal symptoms...
May 6, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
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