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https://www.readbyqxmd.com/read/29313654/lung-cancer-clinical-presentation-and-diagnosis
#1
Kelly M Latimer
In the absence of screening, most patients with lung cancer are not diagnosed until later stages, when the prognosis is poor. The most common symptoms are cough and dyspnea, but the most specific symptom is hemoptysis. Digital clubbing, though rare, is highly predictive of lung cancer. Symptoms can be caused by the local tumor, intrathoracic spread, distant metastases, or paraneoplastic syndromes. Clinicians should suspect lung cancer in symptomatic patients with risk factors. The initial study should be chest x-ray, but if results are negative and suspicion remains, the clinician should obtain a computed tomography scan with contrast...
January 2018: FP Essentials
https://www.readbyqxmd.com/read/29313109/clinical-features-of-chronic-enteropathy-associated-with-slco2a1-gene-a-new-entity-clinically-distinct-from-crohn-s-disease
#2
Junji Umeno, Motohiro Esaki, Atsushi Hirano, Yuta Fuyuno, Naoki Ohmiya, Shigeyoshi Yasukawa, Fumihito Hirai, Shuji Kochi, Koichi Kurahara, Shunichi Yanai, Keiichi Uchida, Shuhei Hosomi, Kenji Watanabe, Naoki Hosoe, Haruhiko Ogata, Tadakazu Hisamatsu, Manabu Nagayama, Hironori Yamamoto, Daiki Abukawa, Fumihiko Kakuta, Kei Onodera, Toshiyuki Matsui, Toshifumi Hibi, Tsuneyoshi Yao, Takanari Kitazono, Takayuki Matsumoto
BACKGROUND: Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a hereditary disease caused by mutations in the SLCO2A1 gene and characterized by multiple small intestinal ulcers of nonspecific histology. SLCO2A1 is also a causal gene of primary hypertrophic osteoarthropathy (PHO). However, little is known about the clinical features of CEAS or PHO. METHODS: Sixty-five Japanese patients recruited by a nationwide survey of CEAS during 2012-2016 were enrolled in this present study...
January 8, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29305259/effectiveness-of-non-steroidal-anti-inflammatory-drugs-among-patients-with-primary-hypertrophic-osteoarthropathy-a-systematic-review
#3
Prakash Shakya, Khem N Pokhrel, Linda B Mlunde, Suyun Tan, Erika Ota, Hironori Niizeki
INTRODUCTION: Primary hypertrophic osteoarthropathy (PHO), also known as pachydermoperiostosis is a rare genetic disease which predominantly affects skin, bone and soft connective tissue. It is characterized by the triad of pachydermia, digital clubbing and periostosis of long bones. Arthralgia or arthritis is also present in most of the cases. Genetic studies have identified the impaired PGE2 metabolism as a culprit for hypertrophic osteoarthropathy in PHO cases. We conducted a systematic review to examine the effectiveness of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), a PGE2 synthesis blocker to reduce the symptoms among PHO patients...
December 28, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29282707/a-novel-mutation-in-the-hpgd-gene-causing-primary-hypertrophic-osteoarthropathy-with-digital-clubbing-in-a-pakistani-family
#4
Anwar Kamal Khan, Noor Muhammad, Sher Alam Khan, Waheed Ullah, Abdul Nasir, Sibtain Afzal, Khushnooda Ramzan, Sulman Basit, Saadullah Khan
Primary hypertrophic osteoarthropathy (PHO) is a congenital multisystemic entity characterized by three major clinical symptoms: pachydermia, periostosis, and digital clubbing. Recently it has been reported that pathogenic mutations in two genes are known to be associated with PHO: HPGD and SLCO2A1. In the present study, a five-generation consanguineous Pakistani family harboring primary hypertrophic osteoarthropathy in autosomal-recessive pattern was ascertained. Whole genome single nucleotide polymorphisms (SNPs) genotyping and sequence analysis revealed a novel homozygous missense mutation (c...
December 28, 2017: Annals of Human Genetics
https://www.readbyqxmd.com/read/29229102/clubbing-in-patients-with-fibrotic-interstitial-lung-diseases
#5
M J G van Manen, L C Vermeer, C C Moor, R Vrijenhoeff, J C Grutters, M Veltkamp, M S Wijsenbeek
BACKGROUND: Clubbing is associated with poor prognosis and is variably present in patients with idiopathic pulmonary fibrosis (IPF), but is also seen in other fibrotic interstitial lung diseases (ILDs). Little is known about the best methodology to assess clubbing in ILDs and, hence, the prevalence and clinical utility and clinical significance of clubbing. We therefore aimed to evaluate the agreement between different clubbing assessment methods in patients with fibrotic ILDs. Additionally, we assessed the prevalence of clubbing in different fibrotic ILDs and related clubbing to disease severity and quality of life...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29208888/polyarthritis-is-a-rare-manifestation-of-pachydermoperiostosis-a-case-report
#6
M F Ahmmed, M N Shazzad, S Ferdous, A K Azad, S A Haq
Pachydermoperiostosis or primary hypertrophic osteoarthropathy, also known as Touraine-Solente-Gole syndrome, is a rare process, frequently inherited. In its complete form it is characterized by pachydermia (thickening of the skin), skeletal changes (periostosis) and acropachia (digital clubbing). Diagnosis can be made considering the typical clinical features and the histological feature. We report a patient of 25-year old man presented with joint pain involving in multiple joints for last 7 years and progressive enlargement of his hands and feet with profuse sweating of palms and soles for last 4 years...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29202503/quantitative-analysis-and-development-of-the-fore-feet-of-arabian-foals-from-birth-to-1-year-of-age
#7
Babak Faramarzi, Allison Salinger, Andris Kaneps, Yvette Nout-Lomas, Holly Greene, Fanglong Dong
Objectives The goal of this study was to quantify external and internal anatomical characteristics of the foal foot throughout the first year of age. Methods Digital radiographs and photographs were taken bimonthly of the forefeet of nine Arabian foals, beginning at about 2 weeks of age until 12 months of age. Sixty-eight linear and angular variables were measured using NIH (National Institutes of Health) Image J software. Statistical analyses were performed using piecewise random coefficient model and p-values < 0...
November 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29164975/digital-clubbing-as-a-first-clinical-presentation-of-pulmonary-metastases-in-cutaneous-melanoma
#8
Faruk Tas, Kayhan Erturk
Digital clubbing is a paraneoplastic phenomenon usually associated with non-small cell lung cancer. We report the development of clubbing in a 49-year old man diagnosed with cutaneous melanoma which had metastasized to the lungs. We also reviewed the literature to understand the association between metastatic melanoma and clubbing. Previous reports of melanoma associated with hypertrophic osteoarthropathy (HOA) are extremely rare; only 7 cases. In all these patients digital clubbing was the main component of the HOA...
November 22, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28963081/identification-of-mutations-in-the-prostaglandin-transporter-gene-slco2a1-and-phenotypic-comparison-between-two-subtypes-of-primary-hypertrophic-osteoarthropathy-pho-a-single-center-study
#9
Yanfang Hou, Yuanyuan Lin, Xuan Qi, Lu Yuan, Ruoxi Liao, Qianqian Pang, Lijia Cui, Yan Jiang, Ou Wang, Mei Li, Jin Dong, Weibo Xia
Primary hypertrophic osteoarthropathy (PHO) is an inherited disease characterized by digital clubbing, periostosis, and pachydermia. Based on two causative genes, hydroxyprostaglandin dehydrogenase (HPGD) and solute carrier organic anion transporter family member 2A1 (SLCO2A1), PHO is categorized into two subtypes: hypertrophic osteoarthropathy, primary, autosomal recessive 1 (PHOAR1) and hypertrophic osteoarthropathy, primary, autosomal recessive 2 (PHOAR2). In this study, we summarized the clinical manifestations and analyzed SLCO2A1 gene in 23 PHOAR2 patients in our center...
September 28, 2017: Bone
https://www.readbyqxmd.com/read/28916395/pachydermoperiostosis-the-value-of-molecular-diagnosis
#10
V Seta, Y Capri, M Battistella, M Bagot, E Bourrat
BACKGROUND: Pachydermoperiostosis is a rare autosomal recessive genetic disorder characterized by the association of periostosis and pachydermia. To date, two genes involved in prostaglandin metabolism, HPGD and SLCO2A1, have been identified. PATIENTS AND METHODS: A 7-year-old girl presented digital clubbing of the hands and feet, curved nails, hyperhidrosis, and pachydermia, as well as eczema of the trunk and limbs. The diagnosis of pachydermoperiostosis was confirmed by the detection of a homozygous mutation in the HPGD gene...
September 12, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28885355/secondary-hypertrophic-osteoarthropathy-caused-by-non-pleural-or-pulmonary-tumors
#11
MULTICENTER STUDY
Hans-Jonas Meyer, Leonard Leifels, Andreas Gunter Bach, Alexey Surov
Hypertrophic osteoarthropathy (HOA) is a rare paraneoplastic syndrome characterized by digital clubbing, periosteal reaction, polyarthralgia, arthritis, and synovitis. Herein, we report a case series of patients with secondary HOA caused by non-pleural or pulmonary tumors.The radiologic databases of 2 tertiary university hospitals were retrospectively screened for secondary HOA patients. In addition, a systemic review of the published case reports. Only HOA cases with non-pleural or pulmonary malignancies were involved into the study...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28878712/how-game-location-affects-soccer-performance-t-pattern-analysis-of-attack-actions-in-home-and-away-matches
#12
Barbara Diana, Valentino Zurloni, Massimiliano Elia, Cesare M Cavalera, Gudberg K Jonsson, M Teresa Anguera
The influence of game location on performance has been widely examined in sport contexts. Concerning soccer, game-location affects positively the secondary and tertiary level of performance; however, there are fewer evidences about its effect on game structure (primary level of performance). This study aimed to detect the effect of game location on a primary level of performance in soccer. In particular, the objective was to reveal the hidden structures underlying the attack actions, in both home and away matches played by a top club (Serie A 2012/2013-First Leg)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28851954/interleukin-6-tumor-necrosis-factor-alpha-and-receptor-activator-of-nuclear-factor-kappa-ligand-are-elevated-in-hypertrophic-gastric-mucosa-of-pachydermoperiostosis
#13
Hui Huang, Yongjun Wang, Yong Cao, Boda Wu, Yonggui Li, Liangliang Fan, Zhiping Tan, Yi Jiang, Jianguang Tang, Jianzhong Hu, Xiaoliu Shi
Pachydermoperiostosis (PDP) is a rare inherited multisystem disease characterized with digital clubbing, pachydermia and periostosis. Variants in either HPGD or SLCO2A1 that interrupt the prostaglandin E2 (PGE2) pathway have been shown to be involved in PDP. Here, in addition to six confirmed variants in HPGD or SLCO2A1, we identified four novel SLCO2A1 variants in eight PDP patients from seven Chinese Han families. In addition, gastric mucosa hyperplasia was observed in all affected individuals and interleukin-6 (IL-6), tumor necrosis factor-alpha (TNFα) and receptor activator of nuclear factor kappa ligand (RANKL) expression were elevated in hypertrophic gastric mucosa...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28770595/high-rates-of-retention-and-viral-suppression-in-the-scale-up-of-antiretroviral-therapy-adherence-clubs-in-cape-town-south-africa
#14
Priscilla Ruvimbo Tsondai, Lynne Susan Wilkinson, Anna Grimsrud, Precious Thembekile Mdlalo, Angelica Ullauri, Andrew Boulle
INTRODUCTION: Increasingly, there is a need for health authority scale up of successfully piloted differentiated models of antiretroviral therapy (ART) delivery. However, there is a paucity of evidence on system-wide outcomes after scale-up. In the Cape Town health district, stable adult patients were referred to adherence clubs (ACs) - a group model of ART delivery with five visits per year. By the end of March 2015, over 32,000 ART patients were in an AC. We describe patient outcomes of a representative sample of AC patients during this scale-up...
July 21, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28690444/the-benefits-of-a-real-time-web-based-response-system-for-enhancing-engaged-learning-in-classrooms-and-public-science-events
#15
Mark A Sarvary, Kathleen M Gifford
Large introduction to neuroscience classes and small science cafés have the same goal: bridging the gap between the presenter and the audience to convey the information while being engaging. Early classroom response systems became the cornerstone of flipped and engaged learning. These "clickers" helped turn lectures into dialogues, allowing the presenter to become a facilitator rather than a "sage on the stage." Rapid technological developments, especially the increase of computing power opened up new opportunities, moving these systems from a clicker device onto cellphones and laptops...
2017: Journal of Undergraduate Neuroscience Education: JUNE: a Publication of FUN, Faculty for Undergraduate Neuroscience
https://www.readbyqxmd.com/read/28441829/-primary-ciliary-dyskinesia-with-hydin-gene-mutations-in-a-child-and-literature-review
#16
REVIEW
L L Chen, Y G Yang, J Z Wu, X R Chen
Objective: To review children's primary ciliary dyskinesia (PCD) in the pathogenesis, clinical manifestation, diagnosis and treatment. Method: To summarize and analyze the clinical data of a patient who was admitted to the first affiliated hospital of Xiamen University with primary ciliary dyskinesia in April 2014 while referring to related literature. Result: An 11 years old boy, weighting about 22 kg, had a course of more than 10 years with repeated cough, stuffy and runny nose shortly after the birth. Examinations after admission to hospital showed that he presented with visible clubbing, bilateral paranasal sinus area tenderness, pharynx posterior wall with visible yellow pussy stuff drip and bilateral lung had scattered wet rales...
April 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28365828/health-integrity-and-doping-in-sports-for-children-and-young-adults-a-resolution-of-the-european-academy-of-paediatrics
#17
Francis P Crawley, Peter Hoyer, Artur Mazur, Liesbeth Siderius, Stefan Grosek, Tom Stiris, David Neubauer
The European Academy of Paediatrics (EAP) is dedicated to promoting healthy lifestyles for children from birth into young adulthood. Physical exercise and leisure are essential to the development of healthy bodies, strong minds, and social skills. All children, without regard to their physical or mental capacities, should be provided with the time, the leadership, the facilities, and the equipment needed to exercise through sports while enjoying playing, even competing, in an environment appropriate to their capacities and aspirations...
April 1, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28339061/identification-of-two-novel-mutations-in-the-slco2a1-prostaglandin-transporter-gene-in-a-chinese-patient-with-primary-hypertrophic-osteoarthropathy
#18
Ting Guo, Kai Yang, Lv Liu, Zhi-Ping Tan, Hong Luo
Primary hypertrophic osteoarthropathy (PHO), which is a rare multi‑organic disease characterized by digital clubbing, pachydermia and periosteal reaction, typically begins during childhood or adolescence and progresses gradually over years prior to disease stabilization. To date, only two genes have been reported to be associated with PHO, 15‑hydroxyprostaglandin dehydrogenase and solute carrier organic anion transporter family, member 2A1 (SLCO2A1). However, the pathogenesis and the functions of the underlying genes remain to be fully elucidated...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28261403/jgme-aliem-hot-topics-in-medical-education-analysis-of-a-multimodal-online-discussion-about-team-based-learning
#19
Jeff Riddell, Catherine Patocka, Michelle Lin, Jonathan Sherbino
BACKGROUND : Team-based learning (TBL) is an instructional method that is being increasingly incorporated in health professions education, although use in graduate medical education (GME) has been more limited. OBJECTIVE : To curate and describe themes that emerged from a virtual journal club discussion about TBL in GME, held across multiple digital platforms, while also evaluating the use of social media in online academic discussions. METHODS : The Journal of Graduate Medical Education (JGME) and the Academic Life in Emergency Medicine blog facilitated a weeklong, open-access, virtual journal club on the 2015 JGME article "Use of Team-Based Learning Pedagogy for Internal Medicine Ambulatory Resident Teaching...
February 2017: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28208841/assessment-of-correlation-between-sweat-chloride-levels-and-clinical-features-of-cystic-fibrosis-patients
#20
Manzoor A Raina, Mosin S Khan, Showkat A Malik, Ab Hameed Raina, Mudassir J Makhdoomi, Javed I Bhat, Syed Mudassar
INTRODUCTION: Cystic Fibrosis (CF) is an autosomal recessive disorder and the incidence of this disease is undermined in Northern India. The distinguishable salty character of the sweat belonging to individuals suffering from CF makes sweat chloride estimation essential for diagnosis of CF disease. AIM: The aim of this prospective study was to elucidate the relationship of sweat chloride levels with clinical features and pattern of CF. MATERIALS AND METHODS: A total of 182 patients, with clinical features of CF were included in this study for quantitative measurement of sweat chloride...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
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