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Gonorrhoea

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https://www.readbyqxmd.com/read/28723967/epitope-determination-of-immunogenic-proteins-of-neisseria-gonorrhoeae
#1
Daniel O Connor, Lena Danckert, Sebastian Hoppe, Frank F Bier, Markus von Nickisch-Rosenegk
Neisseria gonorrhoeae is the causative organism of gonorrhoea, a sexually transmitted disease that globally accounts for an estimated 80 to 100 million new infections per year. Increasing resistances to all common antibiotics used for N. gonorrhoeae treatment pose the risk of an untreatable disease. Further knowledge of ways of infection and host immune response are needed to understand the pathogen-host interaction and to discover new treatment alternatives against this disease. Therefore, detailed information about immunogenic proteins and their properties like epitope sites could advance further research in this area...
2017: PloS One
https://www.readbyqxmd.com/read/28723470/sexually-transmitted-disease-and-male-infertility-a-systematic-review
#2
REVIEW
Mikkel Fode, Ferdinando Fusco, Larry Lipshultz, Wolfgang Weidner
CONTEXT: Theoretically, sexually transmitted diseases (STDs) have the potential to disrupt male fertility; however, the topic remains controversial. OBJECTIVE: To describe the possible association between STDs and male infertility and to explore possible pathophysiologic mechanisms. EVIDENCE ACQUISITION: We performed a systematic literature review in accordance with the PRISMA guidelines. PubMed, Embase, and the Cochrane Library were searched for articles published before January 1, 2016, using the MeSH terms for a variety of STDs and infertility...
October 2016: European Urology Focus
https://www.readbyqxmd.com/read/28717267/semen-culture-and-the-assessment-of-genitourinary-tract-infections
#3
REVIEW
Michael Solomon, Ralf Henkel
The male factor contributes approximately 50% to infertility-related cases in couples with an estimated 12%-35% of these cases attributable to male genital tract infections. Depending on the nature of the infection, testicular sperm production, sperm transport, and sperm function can be compromised. Yet, infections are potentially treatable causes of infertility. Male genital tract infections are increasingly difficult to detect. Moreover, they often remain asymptomatic ("silent") with the result that they are then passed on to the relevant sexual partner leading to fertilization and pregnancy failure as well as illness of the offspring...
July 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28708696/prevalence-of-human-immunodeficiency-virus-and-sexually-transmitted-infections-among-cisgender-and-transgender-women-sex-workers-in-greater-kuala-lumpur-malaysia-results-from-a-respondent-driven-sampling-study
#4
Jeffrey A Wickersham, Britton A Gibson, Alexander R Bazazi, Veena Pillai, Courtney J Pedersen, Jaimie P Meyer, Nabila El-Bassel, Kenneth H Mayer, Adeeba Kamarulzaman, Frederick L Altice
BACKGROUND: Sex workers face a disproportionate burden of human immunodeficiency virus (HIV) and sexually transmitted infections (STI) worldwide. For cisgender women sex workers (CWSW), global HIV prevalence is over 10%, whereas transgender women sex workers (TWSW) face an HIV burden of 19% to 27%. METHODS: We used respondent-driven sampling to recruit 492 sex workers, including CWSW (n = 299) and TWSW (n = 193) in Greater Kuala Lumpur, Malaysia. Participants completed an in-depth survey and were screened for HIV, syphilis, Chlamydia trachomatis, and Neisseria gonorrhoeae...
June 20, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28707659/-drug-resistance-mutations-and-susceptibility-phenotypes-of-neisseria-gonorrhoeae-isolates-in-russia
#5
A A Kubanov, A T Leinsoo, A V Chestkov, E I Dementieva, B L Shaskolskiy, V S Solomka, D A Gryadunov, D G Deryabin
Steady growth in the degree of antimicrobial resistance in Neisseria gonorrhoeae calls for the control of the spreading of resistance mutations. Here we present the data describing drug resistance mutations, the results of antimicrobial susceptibility tests, and molecular genotypes of 128 recent N. gonorrhoeae isolates collected across 9 regions of the Russian Federation. The mutations in chromosome genes penA, ponA, rpsJ, gyrA, parC, which determine the susceptibility of N. gonorrhoeae to penicillins, tetracyclines, and fluoroquinolones were detected by multiplex amplification followed by hybridization on a hydrogel microarray...
May 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28705462/effectiveness-of-a-group-b-outer-membrane-vesicle-meningococcal-vaccine-against-gonorrhoea-in-new-zealand-a-retrospective-case-control-study
#6
Helen Petousis-Harris, Janine Paynter, Jane Morgan, Peter Saxton, Barbara McArdle, Felicity Goodyear-Smith, Steven Black
BACKGROUND: Gonorrhoea is a major global public health problem that is exacerbated by drug resistance. Effective vaccine development has been unsuccessful, but surveillance data suggest that outer membrane vesicle meningococcal group B vaccines affect the incidence of gonorrhoea. We assessed vaccine effectiveness of the outer membrane vesicle meningococcal B vaccine (MeNZB) against gonorrhoea in young adults aged 15-30 years in New Zealand. METHODS: We did a retrospective case-control study of patients at sexual health clinics aged 15-30 years who were born between Jan 1, 1984, and Dec 31, 1998, eligible to receive MeNZB, and diagnosed with gonorrhoea or chlamydia, or both...
July 7, 2017: Lancet
https://www.readbyqxmd.com/read/28705461/gonorrhoea-vaccines-a-step-in-the-right-direction
#7
Kate L Seib
No abstract text is available yet for this article.
July 7, 2017: Lancet
https://www.readbyqxmd.com/read/28705094/auditing-the-use-and-assessing-the-clinical-utility-of-microscopy-as-a-point-of-care-test-for-neisseria-gonorrhoeae-in-a-sexual-health-clinic
#8
Sarah Mensforth, Nicola Thorley, Keith Radcliffe
We assessed whether urethral microscopy was performed as per clinic protocol for male clinic attendees reporting contact with Neisseria gonorrhoeae (GC), urethral symptoms or given a diagnosis of epididymo-orchitis (EO) over a 12-month period (9732 patients). Prevalence of gonorrhoea in the contacts, urethral symptoms and EO groups was 50, 12.7 and 1.6%, respectively. Microscopy was performed reliably for contacts (96%), those with discharge/dysuria with evidence of urethritis on examination (98%), but not those with EO (43%)...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28701272/sexually-transmitted-infections-challenges-ahead
#9
REVIEW
Magnus Unemo, Catriona S Bradshaw, Jane S Hocking, Henry J C de Vries, Suzanna C Francis, David Mabey, Jeanne M Marrazzo, Gerard J B Sonder, Jane R Schwebke, Elske Hoornenborg, Rosanna W Peeling, Susan S Philip, Nicola Low, Christopher K Fairley
WHO estimated that nearly 1 million people become infected every day with any of four curable sexually transmitted infections (STIs): chlamydia, gonorrhoea, syphilis, and trichomoniasis. Despite their high global incidence, STIs remain a neglected area of research. In this Commission, we have prioritised five areas that represent particular challenges in STI treatment and control. Chlamydia remains the most commonly diagnosed bacterial STI in high-income countries despite widespread testing recommendations, sensitive and specific non-invasive testing techniques, and cheap effective therapy...
July 7, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28698342/prevalence-and-antibiotic-resistance-of-mycoplasma-genitalium-among-sti-clinic-attendees-in-western-canada-a-cross-sectional-analysis
#10
Jennifer Gratrix, Sabrina Plitt, LeeAnn Turnbull, Petra Smyczek, Judith Brandley, Ron Scarrott, Prenilla Naidu, Penny Parker, Brenda Blore, Amy Bull, Sandy Shokoples, Lindsay Bertholet, Irene Martin, Max Chernesky, Ron Read, Ameeta Singh
OBJECTIVES: To determine the prevalence and correlates of Mycoplasma genitalium (MG) infection among men and women, determine the prevalence of gene mutations conferring resistance and compare test performance of female specimen types. METHODS: A cross-sectional study was conducted on specimens collected for gonorrhoea (NG, Neisseria gonorrhoeae) and chlamydia (CT, Chlamydia trachomatis) among male and female Alberta STI clinic attendees using the M. genitalium transcription-mediated amplification-research use only test...
July 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28698334/a-randomised-controlled-trial-to-evaluate-the-impact-of-sexual-health-clinic-based-automated-text-message-reminders-on-testing-of-hiv-and-other-sexually-transmitted-infections-in-men-who-have-sex-with-men-in-china-protocol-for-the-t2t-study
#11
Huachun Zou, Xiaojun Meng, Andrew Grulich, Shujie Huang, Tianjian Jia, Xuan Zhang, Zhenzhou Luo, Yi Ding, Ligang Yang, Jinmei Han, Weiying Chen, Heping Zheng, Bin Yang
INTRODUCTION: The frequency of screening for HIV and other sexually transmitted infections (STIs) among men who have sex with men (MSM) is still low in China. METHODS AND ANALYSIS: A sexual health clinic based randomised controlled trial will be conducted in Guangzhou, Wuxi and Shenzhen, China, enrolling 600 MSM. Eligibility will be judged by the pre-programed iPad based questionnaire: (1) age ≥18 years and (2) have had two or more male anal sex partners, or condomless anal sex with a casual male sex partner, or an STI history, in the past 6 months, and (3) provides a valid mobile phone number...
July 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28698211/extra-rectal-lymphogranuloma-venereum-in-france-a-clinical-and-molecular-study
#12
Arnaud Desclaux, Arabella Touati, Didier Neau, Cécile Laurier-Nadalié, Cécile Bébéar, Bertille de Barbeyrac, Charles Cazanave
OBJECTIVES: To describe a series of extrarectal lymphogranuloma venereum (LGV) cases diagnosed in France. METHODS: Consecutive LGV cases confirmed at the French Reference Centre for chlamydiae with an extrarectal sample from January 2010 to December 2015 were included. The first part of the study consisted of a retrospective case note review and analysis. In a second part, the complete ompA gene sequence of our samples was determined. RESULTS: There were 56 cases overall: 50 cases of genital LGV and six cases of pharyngeal LGV...
July 11, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28698183/meningococcal-b-vaccination-also-cuts-risk-of-gonorrhoea-study-suggests
#13
Susan Mayor
No abstract text is available yet for this article.
July 11, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28697843/uriswab-an-effective-transport-medium-for-nucleic-acid-detection-of-chlamydia-trachomatis-mycoplasma-genitalium-and-neisseria-gonorrhoeae
#14
Anna-Maria G Costa, Suzanne M Garland, Rebecca Guy, Handan Wand, Sepehr N Tabrizi
Background: Patient self-sampling allows for remote collection and return to clinic or laboratory by post. Urine samples, although convenient, are challenging to post. This study evaluated UriSwab (Copan, Brescia, Italy) as a collection and transport vessel for Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Mycoplasma genitalium (MG) detection by polymerase chain reaction, compared with flocked swab and neat urine. Methods: Five replicates of each specimen type were prepared from previously characterised urine samples (n=330), stored at room temperature (RT) or 37°C, then extracted on day 1, 3, 7, 10 and 16 (VERSANT kPCR Sample Prep System, Siemens, Munich, Germany)...
July 12, 2017: Sexual Health
https://www.readbyqxmd.com/read/28692536/asymptomatic-anorectal-chlamydia-trachomatis-and-neisseria-gonorrhoeae-infections-are-associated-with-systemic-cd8-t-cell-activation
#15
Vinicius A Vieira, Vivian I Avelino-Silva, Natalia B Cerqueira, Dayane A Costa, Priscilla R Costa, Ricardo P Vasconcelos, Valdez R Madruga, Ronaldo Ismério Moreira, Brenda Hoagland, Valdiléa G Veloso, Beatriz Grinsztejn, Esper G Kallás
BACKGROUND: Oral pre-exposure prophylaxis (PrEP) has been established as a pivotal strategy in HIV prevention. However, bacterial sexually transmitted infections (STIs), such as Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG), are also highly prevalent. Although the presence of STI-related mucosal lesions is a known risk factor for HIV acquisition, the potential increase in risk associated with asymptomatic STIs is not completely understood. Recent data demonstrated higher T cell activation is a risk factor for sexually acquired HIV-1 infection...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28691898/post-transcriptional-regulation-of-target-genes-by-the-srna-fnrs-in-neisseria-gonorrhoeae
#16
Pooja Tanwer, Susanne Bauer, Elisabeth Heinrichs, Gurudutta Panda, Daman Saluja, Thomas Rudel, Dagmar Beier
Small non-coding RNAs (sRNAs) are well-established post-transcriptional regulators of gene expression in bacteria that respond to a variety of environmental stimuli. They usually act by base-pairing with their target mRNAs, which is commonly facilitated by the RNA chaperone Hfq. In this study we initiated the analysis of the sRNA FnrS of Neisseria gonorrhoeae, which is induced under anaerobic conditions. We identified four putative FnrS target genes using bioinformatics approaches and validated these target genes using translational reporter gene fusions in both Escherichia coli and N...
July 10, 2017: Microbiology
https://www.readbyqxmd.com/read/28687628/who-reports-increasing-emergence-of-drug-resistant-gonorrhoea
#17
Anne Gulland
No abstract text is available yet for this article.
July 7, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28686231/antimicrobial-resistance-in-neisseria-gonorrhoeae-global-surveillance-and-a-call-for-international-collaborative-action
#18
Teodora Wi, Monica M Lahra, Francis Ndowa, Manju Bala, Jo-Anne R Dillon, Pilar Ramon-Pardo, Sergey R Eremin, Gail Bolan, Magnus Unemo
In a Policy Forum, Teodora Wi and colleagues discuss the challenges of antimicrobial resistance in gonococci.
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28684610/rapid-accurate-point-of-care-tests-combining-diagnostics-and-antimicrobial-resistance-prediction-for-neisseria-gonorrhoeae-and-mycoplasma-genitalium
#19
Syed Tariq Sadiq, Fulvia Mazzaferri, Magnus Unemo
In addition to inadequate access to early diagnosis and treatment with antimicrobial agents for patients and sexual contacts, management and control of STIs is significantly challenged by emergence and spread of antimicrobial resistance (AMR), particularly for STIs such as Neisseria gonorrhoeae and Mycoplasma genitalium This is further compounded by use of nucleic acid amplification techniques for diagnosis, resulting in reduced phenotypic AMR testing for N. gonorrhoeae and absence or suboptimal AMR surveillance for guiding treatment of both STIs in many settings...
July 6, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28683780/bacterial-agents-and-antibiotic-resistance-profiles-of-infections-from-different-sites-that-occurred-among-patients-at-debre-markos-referral-hospital-ethiopia-a-cross-sectional-study
#20
Wondemagegn Mulu, Bayeh Abera, Mulat Yimer, Tadesse Hailu, Haimanot Ayele, Dereje Abate
BACKGROUND: In developing countries like Ethiopia, infections with antibiotic resistant bacteria become a real threat. Hence, monitoring of local level antimicrobial resistance profile is indispensable to contain the spread of drug resistant bacteria and intervene poor awareness on antimicrobial resistance. Therefore, this study aimed at determining bacterial and antibiotic resistance profiles of infections from different sites that occurred among patients. METHODS: Retrospective data recorded were analyzed on culture and drug susceptibility test results at Debre Markos Referral Hospital which were performed from 2011 to 2014...
July 6, 2017: BMC Research Notes
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