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https://www.readbyqxmd.com/read/28806985/parents-and-teachers-views-on-sexual-health-education-and-screening-for-sexually-transmitted-infections-among-in-school-adolescent-girls-in-kenya-a-qualitative-study
#1
George Wanje, Linnet Masese, Ethel Avuvika, Anisa Baghazal, Grace Omoni, R Scott McClelland
BACKGROUND: To successfully develop and implement school-based sexual health interventions for adolescent girls, such as screening for Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis, it is important to understand parents' and teachers' attitudes towards sexual health education and acceptability of sexually transmitted infection (STI) screening interventions. METHODS: In this qualitative study, we approached parents and teachers from three high schools to participate in in-depth interviews (IDIs) and focus-group discussions (FGDs)...
August 14, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28805699/predicting-and-interpreting-the-structure-of-type-iv-pilus-of-electricigens-by-molecular-dynamics-simulations
#2
Chuanjun Shu, Ke Xiao, Changchang Cao, Dewu Ding, Xiao Sun
Nanowires that transfer electrons to extracellular acceptors are important in organic matter degradation and nutrient cycling in the environment. Geobacter pili of the group of Type IV pilus are regarded as nanowire-like biological structures. However, determination of the structure of pili remains challenging due to the insolubility of monomers, presence of surface appendages, heterogeneity of the assembly, and low-resolution of electron microscopy techniques. Our previous study provided a method to predict structures for Type IV pili...
August 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28803864/the-detection-of-microorganisms-related-to-urethritis-from-the-oral-cavity-of-male-patients-with-urethritis
#3
Phuong Thi Le, Ryoichi Hamasuna, Masahiro Matsumoto, Keiichi Furubayashi, Masayuki Hatanaka, Shuichi Kawai, Takamasa Yamaguchi, Kazutaka Uehara, Norihiko Murakami, Masaru Yoshioka, Ken Nakayama, Yutaka Shiono, Keisuke Muraoka, Masahiko Suzuki, Naohiro Fujimoto, Tetsuro Matsumoto
OBJECTIVES: To investigate the presence of microorganisms related to urethritis in the oral cavity of male patients with urethritis and the efficacies of antimicrobials for urethritis on microorganisms in the oral cavity. METHODS: Ninety-two male patients with urethritis and 17 male controls participated to this study at 12 urology clinics in Japan between March 2014 and March 2015. The first voided urine (FVU) and oral wash fluid (OWF) specimens were collected from the participants...
August 10, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28801418/value-of-light-microscopy-to-diagnose-urogenital-gonorrhoea-a-diagnostic-test-study-in-indonesian-clinic-based-and-outreach-sexually-transmitted-infections-services
#4
I Putu Yuda Hananta, Alje P van Dam, Sylvia Maria Bruisten, Maarten Franciscus Schim van der Loeff, Hardyanto Soebono, Henry John Christiaan de Vries
INTRODUCTION: Gonorrhoea is a common sexually transmitted disease caused by Neisseria gonorrhoeae (Ng) infection. Light microscopy of urogenital smears is used as a simple tool to diagnose urogenital gonorrhoea in many resource-limited settings. We aimed to evaluate the accuracy of light microscopy to diagnose urogenital gonorrhoea as compared with a PCR-based test. METHODS: In 2014, we examined 632 male urethral and 360 endocervical smears in clinic-based and outreach settings in Jakarta, Yogyakarta and Denpasar, Indonesia...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28799824/high-prevalence-of-asymptomatic-sexually-transmitted-infections-among-human-immunodeficiency-virus-infected-pregnant-women-in-a-low-income-south-african-community
#5
Maanda Mudau, Remco P Peters, Lindsey De Vos, Dawie H Olivier, Dvora J Davey, Edwin S Mkwanazi, James A McIntyre, Jeffrey D Klausner, Andrew Medina-Marino
There is a lack of evidence on the burden of Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV) among HIV-infected pregnant women in South Africa. We conducted a cross-sectional analysis of HIV-infected pregnant women in two healthcare facilities in a South African township to determine the prevalence of CT, NG and TV. HIV-infected pregnant women were recruited during the first antenatal care visit for their current pregnancy and requested to self-collect vulvovaginal swab specimens...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28798195/cross-sectional-study-to-evaluate-trichomonas-vaginalis-positivity-in-women-tested-for-neisseria-gonorrhoeae-and-chlamydia-trachomatis-attending-genitourinary-medicine-and-primary-care-clinics-in-bristol-south-west-england
#6
Jane E Nicholls, Katy M E Turner, Paul North, Ralph Ferguson, Margaret T May, Karen Gough, John Macleod, Peter Muir, Patrick J Horner
BACKGROUND: Highly sensitive, commercial nucleic acid amplification tests (NAAT) for Trichomonas vaginalis have only recently been recommended for use in the UK. While testing for T. vaginalis is routine in symptomatic women attending genitourinary medicine (GUM) clinics, it is rare in asymptomatic women or those attending primary care. The aim of this study was to evaluate the positivity of T. vaginalis using a commercial NAAT, in symptomatic and asymptomatic women undergoing testing for chlamydia and gonorrhoea in GUM and primary care settings...
August 10, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28789934/targeting-calpains-a-novel-immunomodulatory-approach-for-microbial-infections
#7
REVIEW
Vijay Kumar, Ahmad Ali
Calpains are a family of Ca(2+) dependent cytosolic non-lysosomal proteases with well conserved cysteine-rich domains for enzymatic activity. Due to their functional dependency on Ca(2+) concentrations, they are involved in various cellular processes that are regulated by intracellular ca(2+) concentration (i.e. embryo development, cell development and migration, maintenance of cellular architecture and structure etc.). Calpains are widely studied proteases in mammalian (i.e. mouse and human) physiology and pathophysiology due to their ubiquitous presence...
August 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28781959/structure-based-design-of-ferritin-nanoparticle-immunogens-displaying-antigenic-loops-of-neisseria-gonorrhoeae
#8
Liqin Wang, Daniel Xing, Adriana Le Van, Ann E Jerse, Shuishu Wang
Effective vaccines are urgently needed to combat gonorrhea, a common sexually transmitted bacterial infection, for which treatment options are diminishing due to rapid emergence of antibiotic resistance. We have used a rational approach to the development of gonorrhea vaccines, and genetically engineered nanoparticles to present antigenic peptides of Neisseria gonorrhoeae, the causative agent of gonorrhea. We hypothesized that the ferritin nanocage could be used as a platform to display an ordered array of N...
August 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28776463/prevalence-and-impact-of-sexually-transmitted-infections-in-pregnant-women-in-central-ethiopia
#9
Andreas Schönfeld, Torsten Feldt, Tafese B Tufa, Hans M Orth, André Fuchs, Million G Mesfun, Frieder Pfäfflin, Tamara Nordmann, Matthias Breuer, Monika Hampl, Dieter Häussinger
Human immunodeficiency virus (HIV) continues to be a major global public health issue and omnipresent sexually transmitted infections (STIs) increase the risk of HIV acquisition. Moreover, STIs and HIV in pregnant women can harm the unborn child. In this study, we systematically investigated the prevalence of HIV, relevant STIs and vaginal group B streptococcus colonization among pregnant women presenting at Asella Teaching Hospital in central Ethiopia and their effect on perinatal mortality. A follow-up was performed six weeks after delivery...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28771632/refinement-of-immunizing-antigens-to-produce-functional-blocking-antibodies-against-the-ania-nitrite-reductase-of-neisseria-gonorrhoeae
#10
Lucy K Shewell, Freda E-C Jen, Michael P Jennings
The emergence of multi-drug resistant Neisseria gonorrhoeae has generated an urgent need for novel therapies or a vaccine to prevent gonococcal disease. In this study we investigate the potential of targeting the surface exposed nitrite reductase, AniA, to block activity by producing functional blocking antibodies. AniA activity is essential for anaerobic growth and biofilm formation of N. gonorrhoeae and functional blocking antibodies may prevent colonisation and disease. Seven peptides covering regions adjacent to the active site were designed based on the AniA structure...
2017: PloS One
https://www.readbyqxmd.com/read/28768469/novel-outreach-settings-to-enhance-sexually-transmitted-infection-hiv-awareness-diagnosis-and-treatment-in-hard-to-reach-populations
#11
T Lampejo, R Turner, C Roberts, K Allen, L Watson, L Caverley-Frost, P Scott, E Ostridge, G Cooney, J Hardy, K Nulty, S Day
Despite recent rises in the number of cases of sexually transmitted infections (STIs) such as syphilis and gonorrhoea in England and increasing rates of HIV diagnosis among several men who have sex with men populations, many individuals are still not engaging with sexual health services. The John Hunter Clinic for Sexual Health, Chelsea and Westminster Hospital, London set up outreach clinics at the two world's largest adult lifestyle exhibitions in 2013 and 2015. This was the first time that a sexual health screening and promotion service was available at these large-scale (over 10,000 attendees at each) adult lifestyle events...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28766431/vaccine-shows-promise
#12
(no author information available yet)
A vaccine to protect against gonorrhoea offers hope in the fight against drug-resistant sexually transmitted infections, according to a study of 14,000 people.
August 2, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28765222/role-of-fatty-acid-kinase-in-cellular-lipid-homeostasis-and-saers-dependent-virulence-factor-expression-in-staphylococcus-aureus
#13
Megan E Ericson, Chitra Subramanian, Matthew W Frank, Charles O Rock
The SaeRS two-component system is a master activator of virulence factor transcription in Staphylococcus aureus, but the cellular factors that control its activity are unknown. Fatty acid (FA) kinase is a two-component enzyme system required for extracellular FA uptake and SaeRS activity. Here, we demonstrate the existence of an intracellular nonesterified FA pool in S. aureus that is elevated in strains lacking FA kinase activity. SaeRS-mediated transcription is restored in FA kinase-negative strains when the intracellular FA pool is reduced either by growth with FA-depleted bovine serum albumin to extract the FA into the medium or by the heterologous expression of Neisseria gonorrhoeae acyl-acyl carrier protein synthetase to activate FA for phospholipid synthesis...
August 1, 2017: MBio
https://www.readbyqxmd.com/read/28762558/mycoplasma-genitalium-an-agent-of-reemerging-sexually-transmitted-infections
#14
Sophie Edouard, Hervé Tissot-Dupont, Grégory Dubourg, Annick Bernard, Pierre-Edouard Fournier, Isabelle Ravaux, Andreas Stein, Didier Raoult
M. genitalium is a reemerging microorganism, responsible for sexually transmissible infections (STIs), with prevalence which varies depending on the country and population group studied. We report here M. genitalium prevalence among the specimens received for STI diagnosis in our routine microbiological laboratory in the university hospital in Marseille, France. We tested 4 624 samples from 3 793 patients using qPCR for M. genitalium, C. trachomatis, N. gonorrheae, T. pallidum. Of these samples, 528 (13.6%) patients were tested positive for at least one pathogen and 126 (3...
August 1, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28754299/antimicrobial-resistance-in-neisseria-gonorrhoeae-history-molecular-mechanisms-and-epidemiological-aspects-of-an-emerging-global-threat
#15
REVIEW
Ana Paula Ramalho da Costa Lourenço, Késia Thaís Barros Dos Santos, Beatriz Meurer Moreira, Sergio Eduardo Longo Fracalanzza, Raquel Regina Bonelli
Neisseria gonorrhoeae is the agent of gonorrhea, a sexually transmitted infection with an estimate from The World Health Organization of 78 million new cases in people aged 15-49 worldwide during 2012. If left untreated, complications may include pelvic inflammatory disease and infertility. Antimicrobial treatment is usually effective; however, resistance has emerged successively through various molecular mechanisms for all the regularly used therapeutic agents throughout decades. Detection of antimicrobial susceptibility is currently the most critical aspect for N...
July 12, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28754106/retesting-and-repeat-positivity-following-diagnosis-of-chlamydia-trachomatis-and-neisseria-gonorrhoea-in-new-zealand-a-retrospective-cohort-study
#16
Sally B Rose, Susan M Garrett, James Stanley, Susan R H Pullon
BACKGROUND: Testing for reinfection at 3 to 6 months following treatment for Chlamydia Trachomatis or Neisseria gonorrhoea is recommended in best practice sexual health management guidelines. This study aimed to describe rates of retesting and repeat positivity following diagnosis of chlamydia or gonorrhoea in a defined geographic region of New Zealand. METHODS: Retrospective cohort study in Wellington, New Zealand involving analysis of laboratory data for chlamydia and gonorrhoea tests performed in primary care and sexual health clinics (July 2012-July 2015)...
July 28, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28753671/self-reported-infections-during-international-travel-and-notifiable-infections-among-returning-international-travellers-sweden-2009-2013
#17
Viktor Dahl, Anders Wallensten
We studied food and water-borne diseases (FWDs), sexually transmitted diseases (STDs), vector-borne diseases (VBDs) and diseases vaccinated against in the Swedish childhood vaccination programme among Swedish international travellers, in order to identify countries associated with a high number of infections. We used the national database for notifiable infections to estimate the number of FWDs (campylobacteriosis, salmonellosis, giardiasis, shigellosis, EHEC, Entamoeba histolytica, yersinosis, hepatitis A, paratyphoid fever, typhoid fever, hepatitis E, listeriosis, cholera), STIs (chlamydia, gonorrhoea and acute hepatitis B), VBDs (dengue fever, malaria, West Nile fever, Japanese encephalitis and yellow fever) and diseases vaccinated against in the Swedish childhood vaccination programme (pertussis, measles, mumps, rubella, diphtheria) acquired abroad 2009-2013...
2017: PloS One
https://www.readbyqxmd.com/read/28747205/detection-of-antibiotic-resistance-is-essential-for-gonorrhoea-point-of-care-testing-a-mathematical-modelling-study
#18
Stephanie M Fingerhuth, Nicola Low, Sebastian Bonhoeffer, Christian L Althaus
BACKGROUND: Antibiotic resistance is threatening to make gonorrhoea untreatable. Point-of-care (POC) tests that detect resistance promise individually tailored treatment, but might lead to more treatment and higher levels of resistance. We investigate the impact of POC tests on antibiotic-resistant gonorrhoea. METHODS: We used data about the prevalence and incidence of gonorrhoea in men who have sex with men (MSM) and heterosexual men and women (HMW) to calibrate a mathematical gonorrhoea transmission model...
July 26, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28747145/human-papillomavirus-infection-among-male-clients-of-female-sex-workers-soliciting-sex-in-brothels-in-peru
#19
Jenell Stewart, Martha Calderon, Alison Hathaway, Rachel L Winer, Joseph Zunt
The prevalence of high-risk human papillomavirus (HR-HPV) has been reported to be three times higher in female sex workers (FSWs) in Callao, Peru than in the general population of women in Peru. Prevalence of HR-HPV among male clients has not yet been reported. A total of 150 men soliciting intercourse in sex work venues submitted questionnaires, samples for sexually transmitted infection (STI) testing, and self-collected penile samples prior to and following intercourse for HPV genotyping. We identified variables associated with pre-coital HR-HPV, and compared HR-HPV detection pre- and post-coitus...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28745556/gonorrhoea-in-greenland-incidence-and-previous-preventive-measures-a-review-to-improve-future-strategies
#20
Sine Berntsen, Anders Peder Højer Karlsen, Michael Lynge Pedersen, Gert Mulvad
Gonorrhoea continues to be a significant health challenge in Greenland. The aim of this study was to describe the development of gonorrhoea in Greenland through time including incidence rates and previous measures taken to address the challenge. A systematic literature search in PubMed, Embase and The Cochrane Library was conducted. Furthermore, local archives were searched in the Health Clinic in Nuuk for relevant literature. From the 1940s the incidence of gonorrhoea increased steadily with a steep incline around 1970, possibly as a consequence of changes in living conditions and urbanisation...
2017: International Journal of Circumpolar Health
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