keyword
MENU ▼
Read by QxMD icon Read
search

Gonorrhoea

keyword
https://www.readbyqxmd.com/read/28930001/antimicrobial-drug-prescription-and-neisseria-gonorrhoeae-susceptibility-united-states-2005-2013
#1
Robert D Kirkcaldy, Monina G Bartoces, Olusegun O Soge, Stefan Riedel, Grace Kubin, Carlos Del Rio, John R Papp, Edward W Hook, Lauri A Hicks
We investigated whether outpatient antimicrobial drug prescribing is associated with Neisseria gonorrhoeae antimicrobial drug susceptibility in the United States. Using susceptibility data from the Gonococcal Isolate Surveillance Project during 2005-2013 and QuintilesIMS data on outpatient cephalosporin, macrolide, and fluoroquinolone prescribing, we constructed multivariable linear mixed models for each antimicrobial agent with 1-year lagged annual prescribing per 1,000 persons as the exposure and geometric mean MIC as the outcome of interest...
October 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28927494/evaluation-of-knowledge-and-utility-of-the-2014-australian-sexually-transmissible-infection-and-hiv-testing-guidelines-for-asymptomatic-men-who-have-sex-with-men-among-general-practitioners-in-sydney
#2
David J Templeton, Phillipe C G Adam, Rajesh Varma, Phillip Read, Chistopher Bourne, Shih-Chi Kao, On Behalf Of The Sexually Transmissible
The Australian sexually transmissible infection and HIV testing guidelines for asymptomatic men who have sex with men were updated in 2014. An evaluation study targeting Sydney-based general practitioners was conducted among 85 clinicians. Respondents with knowledge of guideline recommendations were significantly more likely to feel comfortable asking men who have sex with men about their sexual history (98.1% vs 81.3%, P=0.039), and to recommend at least annual testing (94.0% vs 68.8%, P=0.015), 3-month retesting after chlamydia or gonorrhoea treatment (96...
September 20, 2017: Sexual Health
https://www.readbyqxmd.com/read/28923377/clinical-and-analytical-evaluation-of-the-new-aptima-mycoplasma-genitalium-assay-with-data-on-m-genitalium-prevalence-and-antimicrobial-resistance-in-m-genitalium-in-denmark-norway-and-sweden-in-2016
#3
M Unemo, K Salado-Rasmussen, M Hansen, A O Olsen, M Falk, D Golparian, M Aasterød, J Ringlander, C Steczkó Nilsson, M Sundqvist, K Schønning, H Moi, H Westh, J S Jensen
OBJECTIVES: Mycoplasma genitalium (MG) causes urethritis and cervicitis, potentially causing reproductive complications. Resistance in MG to first-line (azithromycin) and second-line (moxifloxacin) treatment has increased. We examined the clinical and analytical performance of the new CE/IVD Aptima Mycoplasma genitalium assay (CE/IVD AMG; Hologic); the prevalence of MG, Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG); and MG resistance to azithromycin and moxifloxacin in Denmark, Norway and Sweden in 2016...
September 15, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28916651/escherichia-coli-and-neisseria-gonorrhoeae-uvrd-helicase-unwinds-g4-dna-structures
#4
Kaustubh Shukla, Roshan Thakur, Debayan Ganguli, Desirazu Rao, Ganesh Nagaraju
G-quadruplex (G4) secondary structures have been implicated in various biological processes including gene expression, DNA replication and telomere maintenance. However, unresolved G4 structures impede replication progression which can lead to generation of DNA double-strand breaks and genome instability. Helicases have been shown to resolve G4 structures to facilitate faithful duplication of the genome. Escherichia coli UvrD (EcUvrD) helicase plays a crucial role in nucleotide excision repair, mismatch repair and in the regulation of homologous recombination...
September 15, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28910265/kiss-and-tell-limited-empirical-data-on-oropharyngeal-neisseria-gonorrhoeae-among-men-who-have-sex-with-men-and-implications-for-modeling
#5
Kyle T Bernstein, Harrell Chesson, Robert D Kirkcaldy, Julia L Marcus, Thomas L Gift, Sevgi O Aral
No abstract text is available yet for this article.
October 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28904187/genomic-characterization-of-urethritis-associated-neisseria-meningitidis-shows-that-a-wide-range-of-n-meningitidis-strains-can-cause-urethritis
#6
Kevin C Ma, Magnus Unemo, Samo Jeverica, Robert D Kirkcaldy, Hideyuki Takahashi, Makoto Ohnishi, Yonatan H Grad
Neisseria meningitidis, typically a resident of the oro- or nasopharynx and the causative agent of meningococcal meningitis and meningococcemia, is capable of invading and colonizing the urogenital tract. This can result in urethritis, akin to the syndrome caused by its sister species N. gonorrhoeae, the etiologic agent of gonorrhea. Recently, meningococcal strains associated with outbreaks of urethritis were reported to share genetic characteristics with gonococcus, raising the question of the extent to which these strains contain features that promote adaptation to the genitourinary niche, making them gonococcal-like and distinguishing them from other N...
September 13, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28899333/invasive-em-neisseria-gonorrhoeae-em-producing-pre-septal-cellulitis-and-keratoconjunctivitis-diagnosis-and-management
#7
Shivesh Varma, Nathan Wong, Jwu Jin Khong
No abstract text is available yet for this article.
September 18, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28899308/demographic-and-geographical-risk-factors-for-gonorrhoea-and-chlamydia-in-greater-western-sydney-2003-2013
#8
Marianne Gale, Andrew Hayen, George Truman, Rick Varma, Bradley L Forssman, C Raina MacIntyre
INTRODUCTION: Notification rates of sexually transmitted infections (STIs) have increased in New South Wales as elsewhere in Australia. Understanding trends in chlamydia and gonorrhoea notifications at smaller geographical areas may assist public health efforts to deliver targeted STI interventions. METHODS: Routinely collected disease notification data from 2 local health districts within the greater Western Sydney area were analysed. De-identified notifications of gonorrhoea and chlamydia were extracted for people aged over 15 years during the period 1 January 2003 to 31 December 2013...
June 30, 2017: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/28894691/gonococcal-prosthetic-joint-infection
#9
Ian Gassiep, Bradley Gilpin, Joel Douglas, David Siebert
Neisseria gonorrhoea is a common sexually transmitted infection worldwide. Disseminated gonococcal infection is an infrequent presentation and rarely can be associated with septic arthritis. Incidence of this infection is rising, both internationally and in older age groups. We present the first documented case of N. gonorrhoea prosthetic joint infection which was successfully treated with laparoscopic debridement and antimicrobial therapy.
2017: Journal of bone and joint infection
https://www.readbyqxmd.com/read/28893785/in-vitro-activity-of-the-novel-pleuromutilin-lefamulin-bc-3781-and-effect-of-efflux-pump-inactivation-on-multidrug-resistant-and-extensively-drug-resistant-neisseria-gonorrhoeae
#10
Susanne Jacobsson, Susanne Paukner, Daniel Golparian, Jörgen S Jensen, Magnus Unemo
We evaluated the activity of the novel semi-synthetic pleuromutilin lefamulin, inhibiting protein synthesis and growth, and effect of efflux pump inactivation on clinical gonococcal isolates and reference strains (n=251), including numerous multidrug-resistant and extensively-drug resistant isolates. Lefamulin showed potent activity against all gonococcal isolates and no significant cross-resistance to other antimicrobials was identified. Further studies of lefamulin are warranted, including in-vitro selection and mechanisms of resistance, pharmacokinetics/pharmacodynamics, optimal dosing, and performance in randomized controlled trials...
September 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28893203/overall-low-extended-spectrum-cephalosporin-resistance-but-high-azithromycin-resistance-in-neisseria-gonorrhoeae-in-24-european-countries-2015
#11
Michelle J Cole, Gianfranco Spiteri, Susanne Jacobsson, Neil Woodford, Francesco Tripodo, Andrew J Amato-Gauci, Magnus Unemo
BACKGROUND: Surveillance of Neisseria gonorrhoeae antimicrobial susceptibility in Europe is performed through the European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP), which additionally provides data to inform the European gonorrhoea treatment guideline; currently recommending ceftriaxone 500 mg plus azithromycin 2 g as first-line therapy. We present antimicrobial susceptibility data from 24 European countries in 2015, linked to epidemiological data of patients, and compare the results to Euro-GASP data from previous years...
September 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28893183/antimicrobial-resistance-in-africa-a-systematic-review
#12
Birkneh Tilahun Tadesse, Elizabeth A Ashley, Stefano Ongarello, Joshua Havumaki, Miranga Wijegoonewardena, Iveth J González, Sabine Dittrich
BACKGROUND: Antimicrobial resistance (AMR) is widely acknowledged as a global problem, yet in many parts of the world its magnitude is still not well understood. This review, using a public health focused approach, aimed to understand and describe the current status of AMR in Africa in relation to common causes of infections and drugs recommended in WHO treatment guidelines. METHODS: PubMed, EMBASE and other relevant databases were searched for recent articles (2013-2016) in accordance with the PRISMA guidelines...
September 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28886683/neisseria-gonorrhoeae-drug-resistance-mouse-models-and-vaccine-development
#13
Peter A Rice, William M Shafer, Sanjay Ram, Ann E Jerse
Gonorrhea, an obligate human infection, is on the rise worldwide and gonococcal strains resistant to many antibiotics are emerging. Appropriate antimicrobial treatment and prevention, including effective vaccines, are urgently needed. To guide investigation, an experimental model of genital tract infection has been developed in female mice to study mechanisms by which Neisseria gonorrhoeae evades host-derived antimicrobial factors and to identify protective and immunosuppressive pathways. Refinements of the animal model have also improved its use as a surrogate host of human infection and accelerated the testing of novel therapeutic and prophylactic compounds against gonococcal infection...
September 8, 2017: Annual Review of Microbiology
https://www.readbyqxmd.com/read/28886618/bcl10-synergistically-links-ceacam3-and-tlr-dependent-inflammatory-signalling
#14
Anna Sintsova, Cynthia X Guo, Helen Sarantis, Tak W Mak, Michael Glogauer, Scott D Gray-Owen
The neutrophil-specific innate immune receptor CEACAM3 functions as a decoy to capture Gram-negative pathogens, such as Neisseria gonorrhoeae, that exploit CEACAM family members to adhere to the epithelium. Bacterial binding to CEACAM3 results in their efficient engulfment and triggers activation of an NF-κB-dependent inflammatory response by human neutrophils. Herein, we report that CEACAM3 cross-linking is not sufficient for induction of cytokine production, and show that the inflammatory response induced by N...
September 8, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28877506/cryoelectron-microscopy-reconstructions-of-the-pseudomonas-aeruginosa-and-neisseria-gonorrhoeae-type-iv-pili-at-sub-nanometer-resolution
#15
Fengbin Wang, Mathieu Coureuil, Tomasz Osinski, Albina Orlova, Tuba Altindal, Gaël Gesbert, Xavier Nassif, Edward H Egelman, Lisa Craig
We report here cryoelectron microscopy reconstructions of type IV pili (T4P) from two important human pathogens, Pseudomonas aeruginosa and Neisseria gonorrhoeae, at ∼ 8 and 5 Å resolution, respectively. The two structures reveal distinct arrangements of the pilin globular domains on the pilus surfaces, which impart different helical parameters, but similar packing of the conserved N-terminal α helices, α1, in the filament core. In contrast to the continuous α helix seen in the X-ray crystal structures of the P...
September 5, 2017: Structure
https://www.readbyqxmd.com/read/28876323/self-reported-use-of-mouthwash-and-pharyngeal-gonorrhoea-detection-by-nucleic-acid-amplification-test
#16
Eric P F Chow, Sandra Walker, Tim R H Read, Marcus Y Chen, Catriona S Bradshaw, Christopher K Fairley
BACKGROUND: Use of alcohol-containing mouthwash has been found to have an inhibitory effect against pharyngeal gonorrhoea. The aim of this study was to investigate the association between self-reported mouthwash use and pharyngeal gonorrhoea detection among men who have sex with men (MSM). METHODS: A cross-sectional survey was conducted between March 23, 2015, and June 30, 2015 among MSM attending the Melbourne Sexual Health Centre in Australia. Men who have sex with men were invited to complete a short questionnaire on mouthwash use and they were also tested for pharyngeal gonorrhoea by nucleic acid amplification test...
June 15, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28876312/screening-for-sexually-transmitted-infections-in-adolescent-girls-and-young-women-in-mombasa-kenya-feasibility-prevalence-and-correlates
#17
Linnet N Masese, George Wanje, Emmanuel Kabare, Valentine Budambula, Francis Mutuku, Grace Omoni, Anisa Baghazal, Barbra A Richardson, R Scott McClelland
INTRODUCTION: As adolescents and young women become sexually active, they are at risk of adverse reproductive health outcomes including sexually transmitted infections (STIs). We assessed feasibility and acceptability of STI screening among 15- to 24-year-old women in Mombasa, Kenya. METHODS: After sensitization activities, participants were recruited from 3 high schools and 1 university. Study staff conducted informational sessions. Students interested in participating were given consent forms to take home, and invited to visit our clinic for STI screening...
June 28, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28876291/prevalence-of-gonorrhea-and-chlamydia-testing-by-anatomical-site-among-men-who-have-sex-with-men-in-hiv-medical-care-united-states-2013-2014
#18
Monita R Patel, John T Brooks, Yunfeng Tie, Shikha Garg, Heather Bradley
Fewer than one-third of men who have sex with men were tested for Neisseria gonorrhoeae or Chlamydia trachomatis as part of HIV medical care in the United States in 2013 to 2014, and only 11.6% were tested for either sexually transmitted disease at an extragenital site.
August 22, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28876289/neisseria-gonorrhoeae-transmission-among-men-who-have-sex-with-men-an-anatomical-site-specific-mathematical-model-evaluating-the-potential-preventive-impact-of-mouthwash
#19
Lei Zhang, David G Regan, Eric P F Chow, Manoj Gambhir, Vincent Cornelisse, Andrew Grulich, Jason Ong, David A Lewis, Jane Hocking, Christopher K Fairley
BACKGROUND: Gonorrhoea notifications are rapidly rising in men who have sex with men (MSM). We developed a model to assess mouthwash as a novel intervention for gonorrhoea control. METHODS: We developed a model of Neisseria gonorrhoeae (NG) transmission to explain anatomic site-specific prevalence of gonorrhoea among MSM. The model was calibrated to available epidemiological and behavioral data. We estimated the contribution of various sexual acts to gonorrhoea incidence and evaluate the potential impacts of screening scale-up and utilization of mouthwash on the gonorrhoea epidemic...
August 22, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28876284/in-vitro-synergy-testing-of-gentamicin-an-old-drug-suggested-as-future-treatment-option-for-gonorrhoea-in-combination-with-six-other-antimicrobials-against-multidrug-resistant-neisseria-gonorrhoeae-strains
#20
Vikram Singh, Manju Bala, Aradhana Bhargava, Monika Kakran, Ravi Bhatnagar
BACKGROUND: Emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Neisseria gonorrhoeae is a serious concern and combination therapy has been recommended to delay the onset of treatment failures. Gentamicin, an old and inexpensive antibiotic, is recommended in combination with azithromycin for treatment failures cases with the first-line regimen as per the latest Centers for Disease Control and Prevention sexually transmitted disease treatment guidelines. However, not much literature is available on in vitro and in vivo efficacy of this combination...
August 30, 2017: Sexually Transmitted Diseases
keyword
keyword
9585
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"