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https://www.readbyqxmd.com/read/28228492/neisseria-gonorrhoeae-sequence-typing-for-antimicrobial-resistance-ng-star-a-novel-antimicrobial-resistance-multilocus-typing-scheme-for-tracking-the-global-dissemination-of-n-gonorrhoeae-strains
#1
W Demczuk, S Sidhu, M Unemo, D M Whiley, V G Allen, J R Dillon, M Cole, C Seah, E Trembizki, D L Trees, E N Kersh, A J Abrams, H J C de Vries, A P van Dam, I Medina, A Bharat, M R Mulvey, G Van Domselaar, I Martin
A curated web-based user-friendly sequence typing tool based on antimicrobial resistance determinants in Neisseria gonorrhoeae was developed and is publicly accessible at https://ngstar.canada.ca The N. gonorrhoeae Sequence Typing for Antimicrobial Resistance (NG-STAR) molecular typing scheme uses the DNA sequences of 7 genes (penA, mtrR, porB, ponA, gyrA, parC, 23S rRNA) associated with resistance to β-lactam antimicrobials, macrolides, or fluoroquinolones. NG-STAR uses the entire penA sequence combining the historical nomenclature for penA types I-XXXVIII with novel nucleotide sequence designations; the full mtrR sequence and a portion of its promoter region; portions of ponA, porB, gyrA and parC; and 23S rRNA sequences...
February 22, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28216070/corrigendum-to-changes-in-the-six-most-common-sequence-types-of-neisseria-gonorrhoeae-including-st4378-identified-by-surveillance-of-antimicrobial-resistance-in-northern-taiwan-from-2006-to-2013-j%C3%A2-microbiol-immunol-infect-49-5-2016-708-716
#2
Ching-Wai Cheng, Lan-Hui Li, Chen-Yi Su, Shu-Ying Li, Muh-Yong Yen
No abstract text is available yet for this article.
February 16, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28210887/drug-resistant-neisseria-gonorrhoeae-latest-developments
#3
REVIEW
B Suay-García, M T Pérez-Gracia
Gonorrhea is the second most frequently reported notifiable disease in the United States and is becoming increasingly common in Europe. The purpose of this review was to assess the current state of drug-resistant Neisseria gonorrhoeae in order to evaluate future prospects for its treatment. An exhaustive literature search was conducted to include the latest research regarding drug resistance and treatment guidelines for gonorrhea. Gonococci have acquired all known resistance mechanisms to all antimicrobials used for treatment...
February 16, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28209713/mir-718-represses-pro-inflammatory-cytokine-production-through-targeting-pten
#4
Parisa Kalantari, Omid F Harandi, Sarika Agarwal, Florentina Rus, Evelyn A Kurt-Jones, Katherine A Fitzgerald, Daniel R Caffrey, Douglas T Golenbock
Bacterial sepsis involves a complex interaction between the host immune response and bacterial lipopolysaccharides (LPS). LPS binds Toll-like receptor (TLR) 4, which leads to the release of pro-inflammatory cytokines that are essential for a potent innate immune response against pathogens. The innate immune system is tightly regulated as excessive inflammation can lead to organ failure and death. MicroRNAs have recently emerged as important regulators of the innate immune system. Here, we determined the function of miR-718, which is conserved across mammals and overlaps with the 5 UTR of the Interleukin-1 Receptor-Associated Kinase (IRAK1) gene...
February 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28201979/wide-variation-in-sexually-transmitted-infection-testing-and-counselling-at-aboriginal-primary-health-care-centres-in-australia-analysis-of-longitudinal-continuous-quality-improvement-data
#5
Barbara Nattabi, Veronica Matthews, Jodie Bailie, Alice Rumbold, David Scrimgeour, Gill Schierhout, James Ward, Rebecca Guy, John Kaldor, Sandra C Thompson, Ross Bailie
BACKGROUND: Chlamydia, gonorrhoea and syphilis are readily treatable sexually transmitted infections (STIs) which continue to occur at high rates in Australia, particularly among Aboriginal Australians. This study aimed to: explore the extent of variation in delivery of recommended STI screening investigations and counselling within Aboriginal primary health care (PHC) centres; identify the factors associated with variation in screening practices; and determine if provision of STI testing and counselling increased with participation in continuous quality improvement (CQI)...
February 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28201947/including-medical-students-in-research-characteristics-of-participants-and-non-participants-in-the-test-n-treat-feasibility-trial-of-rapid-chlamydia-gonorrhoea-tests
#6
Alastair Green, Elizabeth Pillai, Catherine Smith, Elesha Vooght, Sarah Kerry-Barnard, Charlotte Fleming, Pippa Oakeshott
No abstract text is available yet for this article.
February 15, 2017: Education for Primary Care
https://www.readbyqxmd.com/read/28198339/sexual-health-of-women-aged-40-and-over-attending-an-inner-city-integrated-sexual-health-clinic
#7
Patrice Grech, Rebecca Marchant, Mannampallil Samuel
Sexual health policy remains focussed on younger adults. However, rates of sexually transmitted infections (STIs) in older people continue to increase. We explored the sexual healthcare needs of women aged 40 and over attending an integrated sexual health clinic in South London. We conducted a retrospective case note review and found that almost 20% of these women had STIs. These included genital herpes, trichomoniasis, genital warts, chlamydia and gonorrhoea. Less than a quarter of women reported use of condoms during most recent sexual contact, indicating sexual risk-taking behaviour...
March 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28193667/whole-genome-sequencing-of-a-large-panel-of-contemporary-neisseria-gonorrhoeae-clinical-isolates-indicates-that-a-wild-type-mtra-gene-is-common-implications-for-inducible-antimicrobial-resistance
#8
Eshaw Vidyaprakash, A Jeanine Abrams, William M Shafer, David L Trees
Previous studies (1) have shown that the expression of the mtrCDE efflux pump operon is inducible at the transcriptional level in gonococci during incubation in sub-lethal concentrations of the nonionic detergent Triton X-100, which along with antibiotics, bile salts, progesterone and antimicrobial peptides, is a substrate of the MtrCDE efflux pump (2).….
February 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28192236/diagnosis-of-primary-antibody-and-complement-immunodeficiencies-in-young-adults-after-a-first-invasive-bacterial-infection
#9
Sébastien Sanges, Frédéric Wallet, Nicolas Blondiaux, Didier Theis, Isabelle Verin, Anne Vachée, Rodrigue Dessein, Karine Faure, Nathalie Viget, Eric Senneville, Olivier Leroy, Fleur Maury, Nicolas Just, Julien Poissy, Daniel Mathieu, Anne Prévotat, Cécile Chenivesse, Arnaud Scherpereel, Grégoire Smith, Benjamin Lopez, Jérémie Rosain, Véronique Fremeaux-Bacchi, Eric Hachulla, Pierre-Yves Hatron, Mathilde Bahuaud, Frédéric Batteux, David Launay, Myriam Labalette, Guillaume Lefèvre
OBJECTIVES: Screening for primary immunodeficiencies (PIDs) in adults is recommended after two severe bacterial infections. We aimed to evaluate if screening should be performed after the first invasive infection in young adults. METHODS: Eligible patients were retrospectively identified using hospital discharge and bacteriology databases in 3 centers during a 3-year period. Eighteen to forty year-old patients were included if they had experienced an invasive infection with encapsulated bacteria commonly encountered in PIDs (Streptococcus pneumoniae (SP), Neisseria meningitidis (NM), Neisseria gonorrhoeae (NG), Haemophilus influenzae (HI) or group A Streptococcus (GAS))...
February 10, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28188030/unveiling-of-hiv-dynamics-among-transgender-women-a-respondent-driven-sampling-study-in-rio-de-janeiro-brazil
#10
Beatriz Grinsztejn, Emilia M Jalil, Laylla Monteiro, Luciane Velasque, Ronaldo I Moreira, Ana Cristina F Garcia, Cristiane V Castro, Alícia Krüger, Paula M Luz, Albert Y Liu, Willi McFarland, Susan Buchbinder, Valdilea G Veloso, Erin C Wilson
BACKGROUND: The burden of HIV in transgender women (transwomen) in Brazil remains unknown. We aimed to estimate HIV prevalence among transwomen in Rio de Janeiro and to identify predictors of newly diagnosed HIV infections. METHODS: We recruited transwomen from Rio de Janeiro, Brazil, by respondent-driven sampling. Eligibility criteria were self-identification as transwomen, being 18 years of age or older, living in Rio de Janeiro or its metropolitan area, and having a valid peer recruitment coupon...
February 7, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28182591/comparison-of-cobas-4800-m2000-viper-xtr-and-infinity-80-automated-instruments-when-processing-urine-specimens-for-the-diagnosis-of-chlamydia-trachomatis-and-neisseria-gonorrhoeae
#11
Max A Chernesky, Dan Jang, Jodi Gilchrist, Marek Smieja, Manuel Arias, Todd Hatchette, Andre Poirier, Donna Mayne, Sam Ratnam
OBJECTIVES: North American and European advisory groups recommend testing for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) with nucleic acid amplification tests. Testing is often performed on automated instruments. The objectives of this study were to process urines for the diagnosis of CT and NG and to examine workflow procedures and outcomes. METHODS: While processing 1, 24, 48, 96, and 192 urine specimens on 3 batch-mode systems which use 96-well plates: cobas 4800, m2000, and Viper XTR and the random access cartridge testing GeneXpert Infinity 80, we measured assay performance, hands-on time for processing and maintenance, reagents and plastics consumption, time required to obtain results, and testing accuracy...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28178114/resistance-to-ceftriaxone-and-azithromycin-in-neisseria-gonorrhoeae-isolates-from-7-countries-of-south-america-and-the-caribbean-2010-2011
#12
Sidharath Dev Thakur, Pamela Araya, Graciela Borthagaray, Patricia Galarza, Alina Llop Hernandez, Daisy Payares, Olga Marina Sanabria Cruz, Maria Elena Trigoso Carvallo, Aura Helena Corredor, Jo-Anne R Dillon
Seven countries in Latin America and the Caribbean report on (2010 and 2011) the susceptibility of 2235 isolates of Neisseria gonorrhoeae to 6 antibiotics. Thirteen isolates had ceftriaxone minimum inhibitory concentrations (MICs) of 0.125 to ≥ 0.25 mg/L. The percentage of resistant isolates to the following antibiotics was: azithromycin, 1.0% to 1.7%; ciprofloxacin, 42.1% to 36.2%; penicillin, 31% to 35%; tetracycline, 21.8% to 22.6%.
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28178113/considerations-for-strengthening-surveillance-of-neisseria-gonorrhoeae-antimicrobial-resistance-and-interpreting-surveillance-data
#13
Robert D Kirkcaldy, Karen Schlanger, John R Papp, Elizabeth A Torrone
No abstract text is available yet for this article.
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28178112/antimicrobial-susceptibility-of-neisseria-gonorrhoeae-in-japan-from-2000-to-2015
#14
Mitsuru Yasuda, Kyoko Hatazaki, Shin Ito, Masataka Kitanohara, Mutsumasa Yoh, Munekado Kojima, Harunori Narita, Akira Kido, Kazutoyo Miyata, Takashi Deguch
BACKGROUND: Gonococcal infections are difficult to treat because of their multidrug antimicrobial resistance. The outbreak of antimicrobial-resistant Neisseria gonorrhoeae has begun in Asia and particularly in Japan. Therefore, it is very important that we understand the trend of antimicrobial resistance of N. gonorrhoeae in Asia including Japan. Our surveillance of the antimicrobial susceptibility of N. gonorrhoeae began in 2000 under the guidance of the Department of Urology, Gifu University...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28178111/demographics-behaviors-and-sexual-health-characteristics-of-high-risk-men-who-have-sex-with-men-and-transgender-women-who-use-social-media-to-meet-sex-partners-in-lima-peru
#15
Jeremy Y Chow, Kelika A Konda, Gino M Calvo, Jeffrey D Klausner, Carlos F Cáceres
BACKGROUND: Men who have sex with men (MSM) and transgender women (TW) in Peru bear a disproportionate burden of human immunodeficiency virus (HIV) and sexually transmitted infections (STIs). In a context of quickly expanding communication technology, increasing numbers of MSM and TW are using social media applications to seek sex partners. Understanding social media users and their sex partnering practices is needed to update HIV and STI prevention programming. METHODS: In Lima, Peru, 312 MSM and 89 TW from 2 STI clinics underwent HIV and STI testing and participated in a survey of demographics, behaviors, sexual health, and social media practices...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28178109/risk-factors-for-incidence-of-sexually-transmitted-infections-among-women-in-a-human-immunodeficiency-virus-chemoprevention-trial-voice-mtn-003
#16
Zvavahera Mike Chirenje, Holly M Gundacker, Barbra Richardson, Lorna Rabe, Zakir Gaffoor, Gonasagrie Lulu Nair, Brenda Gati Mirembe, Jeanna M Piper, Sharon Hillier, Jeanne Marrazzo
BACKGROUND: In sub-Saharan Africa, there are limited data on the incidence of sexually transmitted infections (STIs) among women, largely because routine screening for asymptomatic infection is not performed. We conducted a secondary analysis to measure STI incidence rates and determine risk factors for new STI acquisition among women enrolled in the VOICE trial. METHODS: We analyzed data from 4843 women screened for chlamydia, gonorrhoea, syphilis, and trichomonas infection at baseline, annually, at interim visits when clinically indicated and at their study termination visit...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28177463/modified-profile-of-matrix-metalloproteinase-2-and-9-production-by-human-fallopian-tube-epithelial-cells-after-infection-in-vitro-with-neisseria-gonorrhoeae
#17
Paula I Rodas, Doris Pérez, Claudia Jauffret, Yaquelin González, Carolina Carreño, Cecilia V Tapia, Eduardo Osorio, Luis A Velasquez, Myron Christodoulides
No abstract text is available yet for this article.
December 8, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28167140/a-review-of-expedited-partner-therapy-for-the-management-of-sexually-transmitted-infections-in-adolescents
#18
REVIEW
Kathryn E Gannon-Loew, Cynthia Holland-Hall, Andrea E Bonny
INTRODUCTION: Adolescents are at high risk for acquiring and becoming re-infected with sexually transmitted infections (STIs). Partner notification and treatment are essential to preventing the spread of STIs. Expedited partner therapy (EPT) is a method of partner treatment utilized by medical providers to treat patients' sexual partners without direct medical evaluation or counseling. OBJECTIVE: The objective of this article is to review the current literature regarding EPT effectiveness, patients' attitudes and acceptance of EPT, and providers' views and practices surrounding the use of this method of partner treatment...
February 3, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28166698/partner-notification-and-treatment-for-sexually-transmitted-infections-among-pregnant-women-in-gaborone-botswana
#19
Ogechukwu A Offorjebe, Adriane Wynn, Neo Moshashane, Dvora Joseph Davey, Kaitlin Arena, Doreen Ramogola-Masire, Ponatshego Gaolebale, Chelsea Morroni, Jeffrey D Klausner
Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Trichomonas vaginalis (TV) are sexually transmitted infections (STIs) associated with adverse birth outcomes. Untreated partners contribute to high rates of STI reinfection; thus, partner notification and treatment remain important components of STI care and control. A prospective cohort study was conducted among 300 pregnant women presenting to the antenatal clinic at Princess Marina Hospital in Gaborone, Botswana who enrolled in an STI screening study...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28159916/impact-of-deploying-multiple-point-of-care-tests-with-a-sample-first-approach-on-a-sexual-health-clinical-care-pathway-a-service-evaluation
#20
Emma M Harding-Esch, Achyuta V Nori, Aseel Hegazi, Marcus J Pond, Olanike Okolo, Anthony Nardone, Catherine M Lowndes, Phillip Hay, S Tariq Sadiq
OBJECTIVES: To assess clinical service value of STI point-of-care test (POCT) use in a 'sample first' clinical pathway (patients providing samples on arrival at clinic, before clinician consultation). Specific outcomes were: patient acceptability; whether a rapid nucleic acid amplification test (NAAT) for Chlamydia trachomatis/Neisseria gonorrhoeae (CT/NG) could be used as a POCT in practice; feasibility of non-NAAT POCT implementation for Trichomonas vaginalis (TV) and bacterial vaginosis (BV); impact on patient diagnosis and treatment...
February 3, 2017: Sexually Transmitted Infections
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