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https://www.readbyqxmd.com/read/27905998/sexually-transmitted-infections-and-pre-exposure-prophylaxis-challenges-and-opportunities-among-men-who-have-sex-with-men-in-the-us
#1
REVIEW
Hyman M Scott, Jeffrey D Klausner
Pre-Exposure Prophylaxis (PrEP) has shown high efficacy in preventing human immunodeficiency virus (HIV) infection among men who have sex with men (MSM) in several large clinical trials, and more recently in "real world" reports of clinical implementation and a PrEP demonstration project. Those studies also demonstrated high bacterial sexually transmitted infection (STI) incidence and raised the discussion of how PrEP may impact STI control efforts, especially in the setting of increasing Neisseria gonorrhoeae antimicrobial resistance and the increase in syphilis cases among MSM...
January 19, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27904747/comparing-the-disk-diffusion-and-agar-dilution-tests-for-neisseria-gonorrhoeae-antimicrobial-susceptibility-testing
#2
Hsi Liu, Thomas H Taylor, Kevin Pettus, Steve Johnson, John R Papp, David Trees
BACKGROUND: We assessed the validity of testing for antimicrobial susceptibility of clinical and mutant Neisseria gonorrhoeae (GC) isolates by disk diffusion in comparison to agar dilution, and Etest® (bioMerieux, France), respectively, for three third generation extended spectrum cephalosporins (ESC): ceftriaxone (CRO), cefixime (CFX), and cefpodoxime (CPD). METHODS: One hundred and five clinical isolates and ten laboratory-mutants were tested following Clinical Laboratory Standard Institute (CLSI) and manufacturer's standards for each of the three methods...
2016: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/27902415/inversion-of-correia-repeat-enclosed-elements-in-neisseria-gonorrhoeae
#3
Firat Elbeyioglu, Sabrina B Roberts, Russell Spencer-Smith, Madhuri Pulijala, Marta A Zelewska, Jean-Christophe Nebel, Lori As Snyder
Neisseria gonorrhoeae is capable of causing gonorrhoea and more complex diseases in the human host. Within the gonococcal genome are over 100 copies of the IS-like Correia Repeat Enclosed Element, which has been predicted to be mobile within the neisserial genomes. Although there is evidence of ancestral movement of these elements, no previous study has provided evidence for current mobilisation. The Correia Repeat Enclosed Element has the ability to alter gene expression and regulation in many ways: by insertional mutagenesis; by introducing promoter elements; by generating mRNA processing sites, and by association with ncRNAs...
November 16, 2016: Microbiology
https://www.readbyqxmd.com/read/27898572/sexually-transmitted-infections-and-associated-risk-factors-among-street-based-and-residence-based-female-sex-workers-in-dhaka-bangladesh
#4
Rasheda Khanam, Masud Reza, Dilruba Ahmed, Mustafizur Rahman, M Shah Alam, Salima Sultana, Anadil Alam, Sharful I Khan, Kenneth H Mayer, Tasnim Azim
BACKGROUND: Female sex workers (FSWs) in Bangladesh remain at elevated risk of sexually transmitted infections (STIs) although the human immunodeficiency virus (HIV) prevalence among them is low. Recent information on the burden and etiological diagnosis of STIs among them has been lacking. This study examines prevalence and risk behaviors of selected STIs among FSWs in Dhaka in 2014. METHODS: Between August and October 2014, a cross-sectional study was conducted among street-based and residence-based FSWs receiving HIV prevention services at 24 drop in centers in Dhaka...
November 28, 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27898567/utilization-of-the-cepheid-xpert%C3%A2-ct-ng-sample-adequacy-control-to-determine-the-influence-of-the-urethral-swab-on-cellular-content-in-post-swab-versus-pre-swab-urine
#5
Stephen J Jordan, Barbara Van Der Pol, Edward W Hook
Chlamydia trachomatis/Neisseria gonorrhoeae assay performance in males is typically determined using post-swab urine, though pre-swab urine is used in practice. We collected swabs and urine from men and used the Cepheid Xpert® CT/NG sample adequacy control to determine the effect of swab collection on urine cellular content. No difference was observed.
November 28, 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27898565/quantitative-real-time-polymerase-chain-reaction-for-the-diagnosis-of-mycoplasma-genitalium-infection-in-south-african-men-with-and-without-symptoms-of-urethritis
#6
Marie Cecilia le Roux, Anwar Ahmed Hoosen
BACKGROUND: This study was done to diagnose Mycoplasma genitalium infection based on bacterial load in urine specimens from symptomatic and asymptomatic men. METHODS: Urine specimens from 94 men with visible urethral discharge, 206 with burning on micturition and 75 without symptoms presenting to a family practitioner were tested for M. genitalium as well as Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis by transcription-mediated amplification assays...
November 28, 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27898354/vasitis-mimicking-an-amyand-s-hernia-a-case-report
#7
Juan Manuel Romero Marcos, Santiago Baena Bradaschia, José María Muñoz Pérez, José Andrés Cifuentes Ródenas
INTRODUCTION: Amyand's hernia is an inguinal hernia containing the caecal appendix. It is usually an intraoperative finding, although it can be diagnosed preoperatively with radiologic examinations, which would show a tubular structure inside the inguinal canal. PRESENTATION OF CASE: A male patient presented to the emergency department complaining of abdominal pain in the right lower quadrant. He had been orchidectomized during his childhood due to cryptorchidism, and had been under antibiotic treatment a week before due to a suspected gonorrhoea...
November 22, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27895130/metq-of-neisseria-gonorrhoeae-is-a-surface-expressed-antigen-that-elicits-bactericidal-and-functional-blocking-antibodies
#8
Evgeny A Semchenko, Christopher J Day, Kate L Seib
Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection (STI) gonorrhoea, is a growing public health threat for which a vaccine is urgently needed. We have characterized the functional role of the gonococcal MetQ protein, which is the methionine binding component of an ABC transporter system, and assessed its potential as a candidate antigen for inclusion in a gonococcal vaccine. MetQ is highly conserved in all strains investigated to date, it is localized on the bacterial surface, and it binds L-methionine with high affinity...
November 28, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27890419/in-vitro-activity-of-tigecycline-alone-and-antimicrobial-combinations-against-clinical-neisseria-gonorrhoeae-isolates
#9
Hyukmin Lee, Hyunsoo Kim, Young Hee Seo, Dongeun Yong, Seok Hoon Jeong, Kyungwon Lee, Younsop Chong
In this study, we determined the in vitro activity of various combinations of antimicrobial agents against 54 Neisseria gonorrhoeae isolates. The combined activity of ceftriaxone (CRO) and azithromycin (AZM), CRO and doxycycline (DOX), CRO and spectinomycin (SPT), cefixime (CFX) and AZM, CFX and DOX, and CFX and SPT was determined using a checkerboard method. The fractional inhibitory concentration index (FICI) values for all combinations were either additive or indifferent, and no synergistic or antagonistic effects were found...
October 25, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27888365/development-of-a-novel-engineered-antibody-targeting-neisseria-species
#10
Chih-Yueh Liu, Chang-Ching Weng, Chih-Hsiang Lin, Chiou-Ying Yang, Kwok-Kong Tony Mong, Yaw-Kuen Li
OBJECTIVES: A Neissaria bacterial pilus sugar, bacillosamine, was synthesized and, for the first time, used as a probe to screen a single-chain variable fragment (scFv). RESULTS: Four Neisseria, Neisseria gonorrhoeae, Neisseria meningitidis, Neisseria sicca and Neisseria subflava, and two negative controls, Streptococcus pneumoniae and Escherichia coli, were tested through ELISA, immunostaining and gold nanoparticle immunological assay. All results indicated that the selected scFv is feasible for the specific detection of Neisseria species via the recognition of bacillosamine...
November 25, 2016: Biotechnology Letters
https://www.readbyqxmd.com/read/27888206/access-of-non-specialist-sexual-health-services-by-men-who-have-sex-with-men-do-they-differ-from-those-attending-specialist-services
#11
Helen Mebrahtu, Martina Furegato, Bersabeh Sile, John Were, Hamish Mohammed, Gwenda Hughes
OBJECTIVES: Men who have sex with men (MSM) bear a disproportionate burden of STIs. While routine STI surveillance data suggest MSM regularly access specialist genitourinary medicine (GUM) clinics for their sexual healthcare, the extent to which MSM attend non-specialist sexual health services (SHSs) is unclear. METHODS: We used data from the GUM Clinic Activity Data Set (GUMCADv2), the national STI surveillance system, to compare the characteristics, service usage and STI outcomes of MSM accessing specialist and non-specialist (non-GUM) SHSs in England in 2014...
November 25, 2016: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/27885067/repeat-infection-with-neisseria-gonorrhoeae-among-active-duty-u-s-army-personnel-a-population-based-case-series-study
#12
Christian T Bautista, Eyako K Wurapa, Warren B Sateren, Sara M Morris, Bruce P Hollingsworth, Jose L Sanchez
Little information is known on the rate of repeat gonorrhea infection among U.S. military personnel. We analyzed all gonorrhea cases reported to the Defense Medical Surveillance System during 2006-2012 to determine the rate of repeat infection. During the seven-year study period, 17,602 active duty U.S. Army personnel with a first incident gonorrhea infection were reported. Among the 4987 women with a first gonorrhea infection, 14.4% had at least one repeat infection. Among the 12,615 men with a first gonorrhea infection, 13...
November 24, 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27884964/what-are-the-characteristics-of-and-clinical-outcomes-in-men-who-have-sex-with-men-prescribed-hiv-postexposure-prophylaxis-following-sexual-exposure-pepse-at-sexual-health-clinics-in-england
#13
Holly Mitchell, Martina Furegato, Gwenda Hughes, Nigel Field, Anthony Nardone
OBJECTIVES: To explore the risk factors for, and clinical outcomes in men who have sex with men (MSM) prescribed HIV postexposure prophylaxis following sexual exposure (PEPSE) at sexual health clinics (SHCs) in England. METHODS: National STI surveillance data were extracted from the genitourinary medicine clinic activity dataset (GUMCADv2) for 2011-2014. Quarterly and annual trends in the number of episodes where PEPSE was prescribed were analysed by gender and sexual risk...
November 24, 2016: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/27881530/menstrual-cups-and-sanitary-pads-to-reduce-school-attrition-and-sexually-transmitted-and-reproductive-tract-infections-a-cluster-randomised-controlled-feasibility-study-in-rural-western-kenya
#14
Penelope A Phillips-Howard, Elizabeth Nyothach, Feiko O Ter Kuile, Jackton Omoto, Duolao Wang, Clement Zeh, Clayton Onyango, Linda Mason, Kelly T Alexander, Frank O Odhiambo, Alie Eleveld, Aisha Mohammed, Anna M van Eijk, Rhiannon Tudor Edwards, John Vulule, Brian Faragher, Kayla F Laserson
OBJECTIVES: Conduct a feasibility study on the effect of menstrual hygiene on schoolgirls' school and health (reproductive/sexual) outcomes. DESIGN: 3-arm single-site open cluster randomised controlled pilot study. SETTING: 30 primary schools in rural western Kenya, within a Health and Demographic Surveillance System. PARTICIPANTS: Primary schoolgirls 14-16 years, experienced 3 menses, no precluding disability, and resident in the study area...
November 23, 2016: BMJ Open
https://www.readbyqxmd.com/read/27881151/gentamicin-versus-ceftriaxone-for-the-treatment-of-gonorrhoea-g-tog-trial-study-protocol-for-a-randomised-trial
#15
Clare Brittain, Margaret Childs, Lelia Duley, Jan Harding, Trish Hepburn, Garry Meakin, Alan A Montgomery, Wei Tan, Jonathan D C Ross
BACKGROUND: Gonorrhoea is a common sexually transmitted infection which causes genital pain and discomfort; in women it can also lead to pelvic inflammatory disease and infertility, and in men to epididymo-orchitis. Current treatment is with ceftriaxone, but there is increasing evidence of antimicrobial resistance which is reducing its effectiveness against gonorrhoea. A small, but increasing, number of patients have already been found to have highly resistant strains of gonorrhoea which has been associated with clinical failure...
November 24, 2016: Trials
https://www.readbyqxmd.com/read/27872553/development-of-a-novel-test-for-simultaneous-bacterial-identification-and-antibiotic-susceptibility
#16
Jonathan Faro, Malika Mitchell, Yuh-Jue Chen, Sarah Kamal, Gerald Riddle, Sebastian Faro
Background. Elucidation of a pathogen's antimicrobial susceptibility requires subculture after the organism is first isolated. This takes several days, requiring patients to be treated with broad-spectrum antibiotics. This approach contributes to the development of bacterial resistance. Methods. Microtiter wells were coated with a polyclonal antibody targeting the pathogen of interest. Bacterial suspensions were added in the presence/absence of selected antibiotics. After washing, captured bacteria were detected...
2016: Infectious Diseases in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27871264/sti-tests-and-proportion-of-positive-tests-in-female-sex-workers-attending-local-public-health-departments-in-germany-in-2010-11
#17
Viviane Bremer, Karin Haar, Martyna Gassowski, Osamah Hamouda, Stine Nielsen
BACKGROUND: In Germany, local public health departments (LPHD) are required to offer low-threshold access to confidential counselling and testing for sexually transmitted infections (STI) for sex workers. We collected data from LPHD in Germany to estimate the number of performed STI tests and the proportion of positive STI tests among attending female sex workers (FSW) in order to formulate recommendations for improving STI testing and care for FSW in Germany. METHODS: We recruited LPHD across Germany to collect aggregated data on attending FSW between January 2010 and March 2011...
November 21, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27861521/risk-factors-associated-with-paraurethral-duct-dilatation-following-gonococcal-paraurethral-duct-infection-in-men
#18
Wenge Fan, Qingsong Zhang, Lin Wang, Xun Ye, Tingwang Jiang
No studies have explored the risk factors for paraurethral duct dilatation following paraurethral duct infection by Neisseria gonorrhoeae in men undergoing ceftriaxone therapy. The present study was performed to explore the risk factors for paraurethral duct dilatation following paraurethral duct infection by N. gonorrhoeae in men undergoing ceftriaxone therapy and thus guide clinical interventions. We compared the demographic, behavioral, and clinical data of men with paraurethral duct infection by N. gonorrhoeae with and without dilatation of the paraurethral duct...
2016: PloS One
https://www.readbyqxmd.com/read/27836808/mycoplasma-genitalium-and-trichomonas-vaginalis-in-france-a-point-prevalence-study-in-people-screened-for-sexually-transmitted-diseases
#19
Sabine Pereyre, Cécile Laurier Nadalié, Cécile Bébéar
OBJECTIVES: Mycoplasma genitalium and Trichomonas vaginalis are common causes of sexually transmitted infections but limited prevalence data are available in France. We aimed to evaluate the prevalence of M. genitalium and T. vaginalis infections and to assess prevalence by gender, age, sample collection sites and clinical symptoms. A multicentre collection of specimens was intended to obtain a nationwide overview of the epidemiology. METHODS: Between September 2014 and January 2015, 2652 consecutive urogenital specimens submitted to the microbiology diagnostic departments of 16 French university hospitals for Chlamydia trachomatis and Neisseria gonorrhoeae detection were collected...
November 8, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27836225/impact-of-rapid-diagnostic-testing-for-chlamydia-and-gonorrhea-on-appropriate-antimicrobial-utilization-in-the-emergency-department
#20
Kaitlyn R Rivard, Lisa E Dumkow, Heather M Draper, Kasey L Brandt, David W Whalen, Nnaemeka E Egwuatu
Prolonged turnaround time of Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) test results may delay time to notification and treatment of test-positive patients and result in unnecessary antimicrobial use in test-negative patients. This quasi-experimental study evaluated the impact of NG/CT rapid diagnostic testing (RDT) in an urban emergency department (ED) on treatment appropriateness, time to notification, and cost. Patients tested in December 2013-January 2014 (traditional group, n=200) were compared with those in December 2014-January 2015 (RDT group, n=200)...
October 18, 2016: Diagnostic Microbiology and Infectious Disease
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