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Aderson Damiao

Paulo Gustavo Kotze, Takayuki Yamamoto, Aderson O M C Damião
Recurrence is a common event after surgical resections secondary to Crohn´s disease (CD). Endoscopic signs of inflammation, defined as postoperative endoscopic recurrence (PER) occur in up to 90% of the patients after one year. PER precedes clinical recurrence and further need for reoperations due to consequent bowel damage. Therefore, controlling inflammation after surgery in a preventive way is essential for disease control. There is no fixed strategy to prevent recurrence after surgery in CD. There are several risk factors that must be taken into consideration to guide physicians to choose the best therapeutic agents and strategies in this scenario...
November 1, 2015: Current Drug Targets
Fábio Vieira Teixeira, Paulo Gustavo Kotze, Aderson Omar Mourão Cintra Damião, Sender Jankiel Miszputen
Biosimilars are not generic drugs. These are more complex medications than small molecules, with identical chemical structures of monoclonal antibodies that lost their patency over time. Besides identical to the original product at the end, the process of achieving its final forms differs from the one used in the reference products. These differences in the formulation process can alter final outcomes such as safety and efficacy of the drugs. Recently, a biosimilar of Infliximab was approved in some countries, even to the management of inflammatory bowel diseases...
January 2015: Arquivos de Gastroenterologia
Valderílio Feijó Azevedo, Eduardo de Souza Meirelles, Jussara de Almeida Lima Kochen, Ana Cristina Medeiros, Sender J Miszputen, Fábio Vieira Teixeira, Adérson Osmar Mourão Cintra Damião, Paulo Gustavo Kotze, Ricardo Romiti, Marcelo Arnone, Renata Ferreira Magalhães, Cláudia Pires Amaral Maia, André Vicente E de Carvalho
The Brazilian Societies of Rheumatology (SBR) and Dermatology (SBD), the Brazilian Federation of Gastroenterology (FBG) and the Brazilian Study Group on Inflammatory Bowel Disease (GEDIIB) gathered a group of their respective specialists on the topic of interest to discuss the most relevant issues regarding the clinical use of biosimilar medicines in Brazil. The main aim of that meeting was to prepare a document with recommendations to guide medical specialists and to help the national regulatory and policy-making agencies as concerns the authorization for marketing biosimilars used in autoimmune diseases, such as rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Crohn's disease, juvenile idiopathic arthritis and ulcerative colitis...
September 2015: Autoimmunity Reviews
Júlio Maria Fonseca Chebli, Pedro Duarte Gaburri, Liliana Andrade Chebli, Tarsila Campanha da Rocha Ribeiro, André Luiz Tavares Pinto, Orlando Ambrogini Júnior, Adérson Omar Mourão Cintra Damião
Current therapy of moderate-to-severe inflammatory bowel disease (IBD) often involves the use of anti-tumor necrosis factor alpha (TNF-α) agents. Although very effective, theses biologics place the patient at increased risk for developing infections and lymphomas, the latter especially when in combination with thiopurines. Appropriate patient selection, counseling, and education are all important features for the successful use of anti-TNF-α therapy. A thorough history to rule-out contraindications of this therapy and emphasis on monitoring guidelines are important steps preceding administration of anti-TNF-α agents...
March 26, 2014: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Maraci Rodrigues, Maria Fernanda M D'Amico, Fatima Regina Almeida Patiño, Dorina Barbieri, Aderson Omar Mourão Cintra Damião, Aytan M Sipahi, Aytan M Sipahy
OBJECTIVE: This study aimed to describe the clinical, endoscopic, and histologic characteristics, as well as the response to conventional treatment of pediatric patients with the classical form of eosinophilic esophagitis (EoE). METHODS: Study of clinical, laboratory, endoscopic, and histologic data and response to conventional treatment of 43 previously followed pediatric patients with the classical form of EoE. RESULTS: A total of 43 patients diagnosed with EoE were included in the study, of which 37 were males (86%), with a mean age of 8...
March 2013: Jornal de Pediatria
Marília Lage Alencar, Carmen Lucia Ortiz-Agostinho, Lêda Nishitokukado, Adérson O M C Damião, Clarice P Abrantes-Lemos, André Zonetti de Arruda Leite, Thales de Brito, Dalton de Alencar Fischer Chamone, Maria Elizabeth Rossi da Silva, Daniel Giannella-Neto, Aytan Miranda Sipahi
OBJECTIVE: Celiac disease is a permanent enteropathy caused by the ingestion of gluten, which leads to an immunemediated inflammation of the small intestine mucosa. The prevalence of celiac disease varies among different nations and ethnic backgrounds, and its diversity is determined by genetic and environmental factors. São Paulo city is one of the largest cities in the world, with a vast population and an important history of internal migratory flow from other Brazilian regions, as well as immigration from other, primarily European, countries, resulting in significant miscegenation...
September 2012: Clinics
Francine Perrone, Antônio C da-Silva-Filho, Isa F Adôrno, Nadia T Anabuki, Fernando S Leal, Tariane Colombo, Benedito D da Silva, Diana B Dock-Nascimento, Aderson Damião, José E de Aguilar-Nascimento
BACKGROUND: Prolonged preoperative fasting increases insulin resistance and current evidence recommends carbohydrate (CHO) drinks 2 hours before surgery. Our hypothesis is that the addition of whey protein to a CHO-based drink not only reduces the inflammatory response but also diminish insulin resistance. METHODS: Seventeen patients scheduled to cholecystectomy or inguinal herniorraphy were randomized and given 474 ml and 237 ml of water (CO group) or a drink containing CHO and milk whey protein (CHO-P group) respectively, 6 and 3 hours before operation...
2011: Nutrition Journal
Clarice Pires Abrantes-Lemos, Maria Cristina Nakhle, Aderson Omar Mourao Cintra Damiao, Aytan Miranda Sipahi, Flair José Carrilho, Eduardo Luiz R Cancado
BACKGROUND: Sensitivity and specificity of anti-human tissue transglutaminase antibodies (anti-htTGA) seem to be superior to those of anti-tissue transglutaminase of guinea pig (anti-gptTGA) for screening patients with celiac disease (CD), but there are still controversies. The aim of this study was to evaluate the performance of two INOVA ELISA kits to detect IgA anti-htTGA and anti-gptTGA in patients with and without CD. METHODS: The study groups were comprised of 49 anti-endomysial antibody (EMA)-positive untreated-CD, and 123 controls (EMA-negative treated CD, EMA-negative chronic diarrhea, autoimmune hepatitis, inflammatory bowel disease and healthy people)...
2010: Clinical Laboratory
Maria Angélica G Pereira, Carmen L Ortiz-Agostinho, Iêda Nishitokukado, Maria-N Sato, Adérson O M C Damião, Marília L Alencar, Clarice P Abrantes-Lemos, Eduardo L R Cançado, Thales de Brito, Sérgio O Ioshii, Sandra B M Valarini, Aytan M Sipahi
AIM: To determine the prevalence of celiac disease in a group of volunteer blood donors at a blood bank in the city of Curitiba, Brazil through detection of the serum marker immunoglobulin A (IgA) antitransglutaminase antibody. METHODS: Blood samples collected from 2086 healthy subjects at the Paraná State Center for Hematology and Hemotherapy in Curitiba were submitted to ELISA testing for the IgA antitransglutaminase antibody. Positive samples received IgA antiendomysium antibody test through indirect immunofluorescence using human umbilical cord as substrate...
October 28, 2006: World Journal of Gastroenterology: WJG
Ana Luiza Werneck-Silva, Eliana Parisi Alvares, Patrícia Gama, Aderson Omar Mourão Cintra Damião, Luciana Harumi Osaki, Daniela Ogias, Aytan Miranda Sipahi
Strongyloidiasis is an endemic tropical parasitosis caused by Strongyloides stercoralis that also affects immigrants in nontropical countries. The nematode colonizes the duodenum and upper jejunum, inducing mucosal alterations. Because integrity is essential for a functional barrier, we aimed to study apoptosis and proliferation in the small bowel epithelium infected with S. stercoralis. We evaluated 23 patients and 17 controls. Apoptotic cells were detected by TUNEL and M30 immunolabelling, whereas proliferation was scored by Ki67 immunostaining and mitotic counting...
June 2006: Digestive Diseases and Sciences
José Guilherme Nogueira da Silva, Thales De Brito, Adérson Omar Mourão Cintra Damião, Antônio Atílio Laudanna, Aytan Miranda Sipahi
BACKGROUND: There are controversies about the importance of biopsies of normal colon mucosa in the investigation of patients with chronic diarrhea. STUDY: Colonic and terminal ileum biopsies of 167 patients were reviewed. In 5 patients, used as controls, colonoscopy was done due to family history of colon cancer. RESULTS: The 5 patients without symptoms had no histologic abnormalities. The histologic findings in 162 patients with chronic diarrhea were as follows: 110 patients (67...
January 2006: Journal of Clinical Gastroenterology
Carlos Felipe Bernardes-Silva, Adérson O M C Damião, Aytan M Sipahi, Francisco R M Laurindo, Kiyoshi Iriya, Fabio P Lopasso, Carlos A Buchpiguel, Maria Laura L Lordello, Carmem L O Agostinho, Antonio A Laudanna
The aim of this study was to evaluate the effect of ursodeoxycholic acid (UDCA) on intestinal permeability (IP) and reactive oxygen species (ROS) generation in indomethacin-induced enteropathy, a well-known experimental model of Crohn's disease. Seventy-eight male Wistar rats were randomly assigned to receive indomethacin, indomethacin + UDCA, or vehicles. Indomethacin induced a significant increase in the fraction of urinary excretion of 51Cr-EDTA following oral administration (7.9 +/- 1.3 vs 2.3 +/- 0.2%; P < 0...
October 2004: Digestive Diseases and Sciences
Isabella Nicácio de Freitas, Aytan Miranda Sipahi, Adérson O M C Damião, Thales de Brito, Eduardo Luiz Rachid Cançado, Paulo Guilherme Leser, Antonio Atilio Laudanna
UNLABELLED: Forty-eight adult patients with celiac disease between 15 and 68 years of age (mean, 41 years) were studied. Sixty-seven percent were female and 33% were male patients. Most of the patients were white (98%). The main clinical features were diarrhea (90%), weight loss (70%), and abdominal pain (56%). On physical examination, the main findings were pallor (40%), aphthous stomatitis (31%), and arthralgia (23%). Associated disorders included diabetes mellitus type I, osteoporosis, and atopy (6% each); dermatitis herpetiformis and depression (4% each); and hypothyroidism, hyperthyroidism, duodenal carcinoma, and Gilbert syndrome (2% each)...
April 2002: Journal of Clinical Gastroenterology
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