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Sirs pediatric

Franziska Gies, Eva Tschiedel, Ursula Felderhoff-Müser, Peter-Michael Rath, Joerg Steinmann, Christian Dohna-Schwake
BACKGROUND: Antimicrobially pre-treated children with systemic inflammation often pose a diagnostic challenge to the physician. We aimed to evaluate the additional use of SeptiFast multiplex polymerase chain reaction (PCR) to identify causative pathogens in children with suspected systemic bacterial or fungal infection. METHODS: Prospective observational study in 39 children with systemic inflammatory response syndrome (SIRS) under empiric antibiotic treatment. Primary outcome was the rate of positive blood cultures (BC), compared to the rate of positive SeptiFast (SF) results...
2016: BMC Infectious Diseases
Lynne Li, Elise Fortin, Claude Tremblay, Muleka Ngenda-Muadi, Caroline Quach
BACKGROUND Following implementation of bundled practices in 2009 in Quebec and Canadian intensive care units (ICUs), we describe CLABSI epidemiology during the last 8 years in the province of Québec (Canada) and compare rates with Canadian and American benchmarks. METHODS CLABSI incidence rates (IRs) and central venous catheter utilization ratios (CVCURs) by year and ICU type were calculated using 2007-2014 data from the Surveillance Provinciale des Infections Nosocomiales (SPIN) program. Using American and Canadian surveillance data, we compared SPIN IRs to rates in other jurisdictions using standardized incidence ratios (SIRs)...
October 2016: Infection Control and Hospital Epidemiology
Swaantje Barth, Jenny Schlichtiger, Barbara Hartmann, Betty Bisdorff, Hartmut Michels, Katja Radon, Boris Hügle, Linda Walsh, Johannes-Peter Haas
OBJECTIVES: In recent years, concern has been raised about Juvenile Idiopathic Arthritis (JIA) that it could be associated with an increased risk for malignancies. Therefore, the cancer incidence in the JIA patients was evaluated and compared to the cancer incidence in the German population. METHODS: A retrospective single-center hospital-based cohort study was performed using data on the JIA patients treated between 1952 and 2010 at the German Center for Pediatric and Adolescent Rheumatology (GCPAR) (Garmisch-Partenkirchen, Germany)...
July 7, 2016: Modern Rheumatology
Levent Sennaroğlu, Gonca Sennaroğlu, Esra Yücel, Burçak Bilginer, Gamze Atay, M Demir Bajin, Burçe Özgen Mocan, Mehmet Yaral, Filiz Aslan, Betül Çiçek Çnar, Burcu Özkan, Merve Özbal Batuk, Çiğdem Ekin Kirazl, Jale Karakaya, Ahmet Ataş, Sarp Saraç, İbrahim Ziyal
OBJECTIVE: To report the long-term outcomes of children who received auditory brainstem implant (ABI) because of severe inner ear malformations. STUDY DESIGN: Retrospective chart review. SETTING: Tertiary referral otolaryngology clinic. SUBJECTS AND METHODS: Between July 2006 and October 2014, 60 children received ABI at Hacettepe University. Preoperative work up included otolaryngologic examination, audiological assessment, radiological evaluation together with assessment of language development and psychological status...
August 2016: Otology & Neurotology
Kevin J Downes, Scott L Weiss, Jeffrey S Gerber, Sarah B Klieger, Julie C Fitzgerald, Fran Balamuth, Sherri E Kubis, Pam Tolomeo, Warren B Bilker, Xiaoyan Han, Irving Nachamkin, Charles Garrigan, Jennifer H Han, Ebbing Lautenbach, Susan E Coffin
BACKGROUND: Biomarkers that identify critically ill children with systemic inflammatory response syndrome (SIRS) at low risk for bacterial infection may help clinicians reduce unnecessary antibiotic use. METHODS: We conducted a prospective cohort study of children with SIRS and suspected infection admitted to a pediatric intensive care unit from January 5, 2012 to March 7, 2014. We enrolled patients upon initiation of new antibiotics (Time 0) and measured a panel of 8 serum biomarkers daily over 72 hours...
May 4, 2016: Journal of the Pediatric Infectious Diseases Society
Birger Haarbrandt, Thomas Jack, Michael Marschollek
Standard-based integration and semantic enrichment of clinical data originating from electronic medical records has shown to be critical to enable secondary use. To facilitate the utilization of semantic technologies on clinical data, we introduce a methodology to enable automated transformation of openEHR-based data to Web Ontology Language (OWL) individuals. To test the correctness of the implementation, de-identified data of 229 patients of the pediatric intensive care unit of Hannover Medical School has been transformed into 2...
2016: Studies in Health Technology and Informatics
Giuseppe Pontrelli, Franco De Crescenzo, Roberto Buzzetti, Francesca Calò Carducci, Alessandro Jenkner, Donato Amodio, Maia De Luca, Sara Chiurchiù, Elin Haf Davies, Alessandra Simonetti, Elena Ferretti, Martina Della Corte, Luca Gramatica, Susanna Livadiotti, Paolo Rossi
BACKGROUND: Differential diagnosis between sepsis and non-infectious inflammatory disorders demands improved biomarkers. Soluble Triggering Receptor Expression on Myeloid cells (sTREM-1) is an activating receptor whose role has been studied throughout the last decade. We performed a systematic review to evaluate the accuracy of plasma sTREM-1 levels in the diagnosis of sepsis in children with Systemic Inflammatory Response Syndrome (SIRS). METHODS: A literature search of PubMed, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and ISI Web of Knowledge databases was performed using specific search terms...
2016: Italian Journal of Pediatrics
Talita le Roux, Bart Vinck, Iain Butler, Nicolize Cass, Liebie Louw, Leone Nauta, Dani Schlesinger, Maggi Soer, Mashudu Tshifularo, De Wet Swanepoel
OBJECTIVE: To identify and describe predictors of pediatric cochlear implantation outcomes in a South African population. METHODS: A retrospective study of 301 pediatric cochlear implant (CI) recipients from five CI programs was conducted and cross-sectional outcome data were added at the time of data collection. Twenty potential prognostic factors were identified from the retrospective dataset, including demographical, CI, risk and family factors. Multiple regression analyses were performed to identify predictor variables that influence outcomes in terms of auditory performance (CAP scores), speech production (SIR scores), communication mode and educational placement...
May 2016: International Journal of Pediatric Otorhinolaryngology
I Pągowska-Klimek, A S Świerzko, M Michalski, E Głowacka, A Szala-Poździej, A Sokołowska, M Moll, W R Krajewski, J Romak, M Cedzyński
The systemic inflammatory response is a challenge in the management of paediatric patients undergoing cardiac surgery. Although multi-factorial, a contribution by the lectin pathway of complement activation has been postulated. We therefore investigated the changes in serum levels of mannose binding lectin (MBL) and activities of MBL-MBL-associated serine protease (MASP)-1 and MBL-MASP-2 complexes immediately before and during surgery, throughout the first postoperative day and at discharge from the hospital...
May 2016: Clinical and Experimental Immunology
Steven Barron Frazier, Robert Sepanski, Christopher Mangum, Christine Bovat, Arno Zaritsky, Sandip Godambe
OBJECTIVES: Systemic inflammatory response syndrome (SIRS) may complicate pneumonia. When present, it suggests that the patient's pneumonia is more severe. As such, recognition of SIRS among patients with pneumonia may be helpful in identifying those requiring more careful evaluation. Our objective was to examine the relation between the presence of SIRS and adverse clinical outcomes among children with pneumonia seen in the emergency department (ED). METHODS: A retrospective chart review was performed on children diagnosed as having community-acquired pneumonia who presented to a children's hospital ED during a 3-month period...
November 2015: Southern Medical Journal
Izabela Pągowska-Klimek, Anna S Świerzko, Mateusz Michalski, Maciej Moll, Agnieszka Szala-Poździej, Anna Sokołowska, Wojciech R Krajewski, Maciej Cedzyński
We investigated MBL2 and MASP2 genotypes, serum MBL (mannose-binding lectin) levels and activities of its complexes with associated serine proteases (MASP-1, MASP -2), in relation to complications following cardiac surgery in 195 children. The incidence of SIRS was lower in patients carrying MBL2 A/O and O/O genotypes (p=0.024). Children with MBL levels <500ng/ml had a lower risk of SIRS (p=0.014) and fever (p=0.044). Median MBL concentration was higher in patients who developed SIRS (p=0.048) but lower in those with post-operative infections (p=0...
February 2016: Immunobiology
Esra Yücel, Filiz Aslan, Hilal Burcu Özkan, Levent Sennaroğlu
OBJECTIVE: The aim of this study is to describe the rehabilitative outcomes of pediatric auditory brainstem implant (ABI) users in the Department of Otolaryngology in the Hacettepe University. It was a retrospective study, and all patients' files were reviewed. MATERIALS AND METHODS: The data was collected from 41 children who were fitted with ABI between 2005 and 2013. Inclusion criteria for children in our study are profound, congenital bilateral sensory-neural hearing loss with anomalies (such as cochlear, labyrinthine, and cochlear nerve aplasia) and more than one year of auditory experience with ABI...
August 2015: Journal of International Advanced Otology
Natasha M Archer, Renata Parada Amorim, Rafaela Naves, Simone Hettmer, Lisa R Diller, Karina Braga Ribeiro, Carlos Rodriguez-Galindo
BACKGROUND: Rhabdomyosarcoma survivors have an increased risk of developing second malignant neoplasms (SMN); this risk is traditionally attributed to the effects of multidisciplinary management required for cure. However, the impact of constitutional predisposition has not been properly analyzed. METHODS: We analyzed the risk of SMN among 1,151 children diagnosed with rhabdomyosarcoma and reported to the Surveillance, Epidemiology, and End Results registries (SEER-9) from 1973 to 2010...
February 2016: Pediatric Blood & Cancer
Jason D Pole, Lan Ying Gu, Victoria Kirsh, Mark L Greenberg, Paul C Nathan
BACKGROUND: The purpose was to describe the development of subsequent malignant neoplasms (SMN) among a population-based cohort of pediatric cancer patients, with a focus on SMNs that occurred within the first 5 years from diagnosis. METHODS: The cohort was identified from POGONIS, an active provincial registry. Cohort members were Ontario residents ages 0 to 14.9 years at primary diagnosis between January 1985 and December 2008. SMNs that developed <18 years were captured by POGONIS, whereas SMNs diagnosed later were identified through linkage...
October 2015: Cancer Epidemiology, Biomarkers & Prevention
Junjing Fu, Yongtao Wang, Ping Zeng, Shanshan Niu
OBJECTIVE: To evaluate interleukin-27 (IL-27) as a sepsis diagnostic biomarker in critically ill adults with sepsis. METHODS: A retrospetive study was conducted. A total of 176 systemic inflammatory response syndrome (SIRS) patients in Department of Critical Care Medicine of Xinxiang Medical College First Affiliated Hospital from March to November in 2014 were enrolled. The patients were divided into no sepsis group (n=66), pulmonary originated sepsis group (n=65), and non-pulmonary originated sepsis group (n=45)...
June 2015: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Wolfgang Dörffel, Marianne Riepenhausenl, Heike Lüders, Jürgen Brämswig, Günther Schellong
BACKGROUND: About 155 persons under age 18 develop Hodgkin's lymphoma (HL) in Germany every year. More than 90% survive at least 20 years. They may, however, suffer from late sequelae of treatment, including secondary malignant neoplasia (SMN). METHODS: 2548 patients from the German, Austrian, and Swiss pediatric Hodgkin's lymphoma studies that were conducted over the period 1978-2002 were asked every 2-3 years about possible late sequelae of treatment, either directly or through their physicians...
May 1, 2015: Deutsches Ärzteblatt International
Petra Temming, Anja Viehmann, Marina Arendt, Lewin Eisele, Claudia Spix, Norbert Bornfeld, Wolfgang Sauerwein, Karl-Heinz Jöckel, Dietmar R Lohmann
BACKGROUND: Children with retinoblastoma carry a high risk to develop second primary malignancies in childhood and adolescence. This study characterizes the type of pediatric second primary malignancies after retinoblastoma treatment and investigates the impact of different treatment strategies and prognostic factors at presentation. PROCEDURE: All national patients treated for retinoblastoma at the German referral center with a current age of 6-27 years were invited to participate in a study to characterize late effects...
October 2015: Pediatric Blood & Cancer
Gene S Fisch
Developmental trajectories in behavioral phenotypes are important areas for systematic research and have been for more than 30 years. They interweave several important strands related to human growth: that of individuals born with some form of intellectual impairment or disability (ID); second, the genetics associated with intellectual ability and disability; and third, at the behavioral level, the dynamic expression and variability of specific abnormalities as individuals age. ID, and the genetic disorders that produce ID, were often not well-received by earlier societies...
June 2015: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
Philippa Rees, Adrian Edwards, Sukhmeet Panesar, Colin Powell, Ben Carter, Huw Williams, Peter Hibbert, Donna Luff, Gareth Parry, Sharon Mayor, Anthony Avery, Aziz Sheikh, Sir Liam Donaldson, Andrew Carson-Stevens
BACKGROUND: In the United Kingdom, 26% of child deaths have identifiable failures in care. Although children account for 40% of family physicians' workload, little is known about the safety of care in the community setting. Using data from a national patient safety incident reporting system, this study aimed to characterize the pediatric safety incidents occurring in family practice. METHODS: We undertook a retrospective, cross-sectional, mixed methods study of pediatric reports submitted to the UK National Reporting and Learning System from family practice...
June 2015: Pediatrics
Alvin D Jeffery, Karen Steffen Mutsch, Lisa Knapp
BACKGROUND: A large amount of research demonstrates the importance of key interventions in reducing mortality rates of pediatric patients with sepsis (Dellinger et al., 2008). Assessment and recognition of declining status must occur for interventions to be initiated. Of health care practitioners, nurses typically spend the most time with patients, and they must be knowledgeable in recognizing the systemic inflammatory response syndrome and sepsis while also being aware of the importance of prompt intervention...
November 2014: Pediatric Nursing
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