David F Colón, Carlos W Wanderley, Marcelo Franchin, Camila M Silva, Carlos H Hiroki, Fernanda V S Castanheira, Paula B Donate, Alexandre H Lopes, Leila C Volpon, Silvia K Kavaguti, Vanessa F Borges, Cesar A Speck-Hernandez, Fernando Ramalho, Ana P Carlotti, Fabio Carmona, Jose C Alves-Filho, Foo Y Liew, Fernando Q Cunha
BACKGROUND: Neutrophil extracellular traps (NETs) are innate defense mechanisms that are also implicated in the pathogenesis of organ dysfunction. However, the role of NETs in pediatric sepsis is unknown. METHODS: Infant (2 weeks old) and adult (6 weeks old) mice were submitted to sepsis by intraperitoneal (i.p.) injection of bacteria suspension or lipopolysaccharide (LPS). Neutrophil infiltration, bacteremia, organ injury, and concentrations of cytokine, NETs, and DNase in the plasma were measured...
April 8, 2019: Critical Care: the Official Journal of the Critical Care Forum