keyword
https://read.qxmd.com/read/38529371/the-learning-curve-and-experience-of-a-novel-multi-modal-image-fusion-targeted-transperineal-prostate-biopsy-technique-using-electromagnetic-needle-tracking-under-local-anesthesia
#21
JOURNAL ARTICLE
Yongjun Yang, Xianya He, Yiming Zeng, Qiang Lu, Yuanwei Li
BACKGROUND: Prostate cancer is the most common malignant tumor of male genitourinary system, and the gold standard for its diagnosis is prostate biopsy. Focusing on the methods and skills of prostate biopsy, we explored the learning curve and experience of a novel magnetic resonance imaging and transrectal ultrasound (mpMRI-TRUS) image fusion transperineal biopsy (TPB) technique using electromagnetic needle tracking under local anesthesia. METHODS: The clinical and pathological data of 92 patients who underwent targeted TPB from January 2023 to July 2023 in our center were prospectively collected...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38529369/diagnosis-of-benign-and-malignant-peripheral-lung-lesions-based-on-a-feature-model-constructed-by-the-random-forest-algorithm-for-grayscale-and-contrast-enhanced-ultrasound
#22
JOURNAL ARTICLE
Hong Wei, Yichun Wang, Jinyao Li, Yanyan Wang, Longdi Lu, Jiawei Sun, Xiaolei Wang
RATIONALE AND OBJECTIVES: To construct a predictive model for benign and malignant peripheral pulmonary lesions (PPLs) using a random forest algorithm based on grayscale ultrasound and ultrasound contrast, and to evaluate its diagnostic value. MATERIALS AND METHODS: We selected 254 patients with PPLs detected using chest lung computed tomography between October 2021 and July 2023, including 161 malignant and 93 benign lesions. Relevant variables for judging benign and malignant PPLs were screened using logistic regression analysis...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38529270/from-biology-to-clinical-practice-antiproliferative-effects-of-somatostatin-analogs-in-neuroendocrine-neoplasms
#23
REVIEW
Philipp Melhorn, Peter Mazal, Ladislaia Wolff, Elisabeth Kretschmer-Chott, Markus Raderer, Barbara Kiesewetter
Somatostatin analogs (SSA), specifically octreotide and lanreotide, have demonstrated antiproliferative effects in patients with neuroendocrine tumors (NET), a group of rare malignancies of diverse origin and presentation. A prominent feature of NET cells is the expression of G protein-coupled receptors called somatostatin receptors (SSTR). Although these SSTR are not uniformly present in NET, they can be instrumental in the diagnosis and treatment of NET. Apart from their application in nuclear imaging and radionuclide therapy, SSA have proven invaluable in the treatment of hormonal syndromes associated with certain NET (antisecretory effects of SSA), but it took more than two decades to convincingly demonstrate the antiproliferative effects of SSA in metastatic NET with the two pivotal studies PROMID and CLARINET...
2024: Therapeutic Advances in Medical Oncology
https://read.qxmd.com/read/38527626/infrared-microspectroscopy-to-elucidate-the-underlying-biomolecular-mechanisms-of-flash-radiotherapy
#24
JOURNAL ARTICLE
Immaculada Martínez-Rovira, Pierre Montay-Gruel, Benoît Petit, Ron Leavitt, Roberto González-Vegas, Pascal Froidevaux, Marjorie Juchaux, Yolanda Prezado, Ibraheem Yousef, Marie-Catherine Vozenin
BACKGROUND: FLASH-radiotherapy (FLASH-RT) is an emerging modality that uses ultra-high dose rates of radiation to enable curative doses to the tumor while preserving normal tissue. The biological studies showed the potential of FLASH-RT to revolutionize radiotherapy cancer treatments. However, the complex biological basis of FLASH-RT is not fully known yet. AIM: Within this context, our aim is to get deeper insights into the biomolecular mechanisms underlying FLASH-RT through Fourier Transform Infrared Microspectroscopy (FTIRM)...
March 23, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38527441/potential-of-using-qfibrosis-analysis-to-predict-recurrent-and-survival-outcome-of-patients-with-hepatocellular-carcinoma-after-hepatic-resection
#25
JOURNAL ARTICLE
Chih-Yang Hsiao, Yayun Ren, Elaine Chng, Dean Tai, Kai-Wen Huang
BACKGROUND: There remains a lack of studies addressing the stromal background and fibrosis features and its prognostic value in liver cancer. qFibrosis can identify, quantify and visualize the fibrosis features from biopsy samples. In this study, we aim to demonstrate the prognostic value of histological features by using qFibrosis analysis in liver cancer patients. METHODS: Liver specimen from 201 patients with hepatocellular carcinoma underwent curative resection were imaged and assessed using qFibrosis system, and generated a total of 33 and 156 collagen parameters from tumor part and non-tumor liver tissue, respectively...
March 25, 2024: Oncology
https://read.qxmd.com/read/38525423/application-of-three-dimensional-technology-in-video-assisted-thoracoscopic-surgery-sublobectomy
#26
Xinyu Zhang, Di Yang, Linqian Li, Jianing Wang, Si Liang, Peng Li, Zhe Han, Xiaodong Wang, Ke Zhang
BACKGROUND: Due to the widespread use of imaging techniques, the detection rate of early-stage lung cancer has increased. Video-assisted thoracoscopic surgery (VATS) sublobectomy has emerged as a prominent alternative to lobectomy, offering advantages like reduced resection range, better preservation of lung function, and enhanced postoperative quality of life. However, sublobectomy is more intricate than lobectomy, necessitating a higher level of surgical proficiency and anatomical understanding...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38525420/the-promise-and-challenges-of-multi-cancer-early-detection-assays-for-reducing-cancer-disparities
#27
JOURNAL ARTICLE
Cheryl L Thompson, Monica L Baskin
Since improvements in cancer screening, diagnosis, and therapeutics, cancer disparities have existed. Marginalized populations (e.g., racial and ethnic minorities, sexual and gender minorities, lower-income individuals, those living in rural areas, and persons living with disabilities) have worse cancer-related outcomes. Early detection of cancer substantially improves outcomes, yet uptake of recommended cancer screenings varies widely. Multi-cancer early detection (MCED) tests use biomarkers in the blood to detect two or more cancers in a single assay...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38525415/rim-enhancement-of-pancreatic-ductal-adenocarcinoma-investigating-the-relationship-with-dce-mri-based-radiomics-and-next-generation-sequencing
#28
JOURNAL ARTICLE
Moon Hyung Choi, Seung Bae Yoon, Young Joon Lee, Eun Sun Jung, Seongyong Pak, Dongyeob Han, Dominik Nickel
PURPOSE: To identify the clinical and genetic variables associated with rim enhancement of pancreatic ductal adenocarcinoma (PDAC) and to develop a dynamic contrast-enhanced (DCE) MRI-based radiomics model for predicting the genetic status from next-generation sequencing (NGS). MATERIALS AND METHODS: Patients with PDAC, who underwent pretreatment pancreatic DCE-MRI between November 2019 and July 2021, were eligible in this prospective study. Two radiologists evaluated presence of rim enhancement in PDAC, a known radiological prognostic indicator, on DCE MRI...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38524869/radiomics-signature-of-osteoarthritis-current-status-and-perspective
#29
REVIEW
Tianshu Jiang, Sing-Hin Lau, Jiang Zhang, Lok-Chun Chan, Wei Wang, Ping-Keung Chan, Jing Cai, Chunyi Wen
UNLABELLED: Osteoarthritis (OA) is one of the fast-growing disability-related diseases worldwide, which has significantly affected the quality of patients' lives and brings about substantial socioeconomic burdens in medical expenditure. There is currently no cure for OA once the bone damage is established. Unfortunately, the existing radiological examination is limited to grading the disease's severity and is insufficient to precisely diagnose OA, detect early OA or predict OA progression...
March 2024: Journal of Orthopaedic Translation
https://read.qxmd.com/read/38524258/pancreatic-adenosquamous-carcinoma-presenting-as-a-gastric-lesion
#30
Dain Raina Kim, Travis Ogilvie, Matthew Woo
Pancreatic adenosquamous carcinoma, an uncommon subtype of pancreatic adenocarcinoma, is characterized by an aggressive course and poor prognosis, with the only method of cure being surgical resection at the time of diagnosis. It is a complex condition, as it presents nonspecifically and remains indistinguishable from pancreatic adenocarcinoma without imaging techniques despite its aggressive nature. We report an atypical case of pancreatic adenosquamous carcinoma, presenting with marked anemia, found on endoscopy to have a gastric mass...
March 2024: ACG Case Reports Journal
https://read.qxmd.com/read/38524061/paget-s-presentation-of-high-grade-ductal-carcinoma-in-situ-dcis-in-a-very-young-female-with-breast-cancer-2-brca2-mutation
#31
Sneha Butala, Chancée Forestier, Sugeetha Nithiananthan, Asilis J Defran, Nafisa K Kuwajerwala
This is a case of a previously healthy 29-year-old female with erythema and skin excoriations of the left breast nipple-areolar complex (NAC). After a repeat trial and failure of topical hydrocortisone, a diagnostic mammogram and nipple biopsy revealed Paget's disease (PD) of the nipple with ductal carcinoma in situ (DCIS). A subsequent genetic analysis found a breast cancer 2 ( BRCA2 ) gene mutation. Treatment consisted of a left breast skin-sparing simple mastectomy with sentinel lymph node (SLN) biopsy and immediate tissue expander placement for implant reconstruction...
February 2024: Curēus
https://read.qxmd.com/read/38523726/breast-metastasis-an-unusual-cause-of-malignant-breast-lesion
#32
JOURNAL ARTICLE
Dunkan Petersbourg
Teaching point: Although rare, an intra-mammary metastasis from extramammary cancer should be considered in a patient with an oncological history.
2024: Journal of the Belgian Society of Radiology
https://read.qxmd.com/read/38522767/pain-relief-related-structural-brain-alterations-in-trigeminal-neuralgia-induced-by-non-invasive-stereotactic-radiosurgery-a-pilot-study
#33
JOURNAL ARTICLE
Jonas Kolodziej, Bogdan Pintea, Jan Patrick Boström, Burkhard Pleger
PURPOSE: Trigeminal neuralgia (TN) is a devastating chronic pain disorder, defined by unilateral shock like pain in at least one division of the trigeminal nerve. Although several studies have investigated structural brain plasticity in TN patients, treatment-induced alterations remain largely uninvestigated. MATERIALS/METHODS: Combining T1-weighted magnetic resonance imaging (MRI) with voxel-based morphometry (VBM) and multiple-regression analyses, we assessed gray matter maps of TN patients to investigate changes in gray matter volume (GMV) from before to half a year after stereotactic radiosurgery (SRS)...
March 22, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38522333/omission-of-breast-surgery-in-selected-breast-cancer-patients-with-excellent-response-to-neoadjuvant-systemic-therapy
#34
JOURNAL ARTICLE
Marios-Konstantinos Tasoulis, Samantha Muktar, Ian Smith, Nicola Roche, Fiona MacNeill
Modern neoadjuvant systemic therapy (NST) can result in high pathologic complete response rates (pCR) in triple negative (TN) and human epidermal growth factor receptor 2 positive (HER2+) breast cancer. The role of surgery is, therefore, being reconsidered in this rapidly evolving field. This report presents oncological outcomes of seven patients with TN or HER2+ breast cancer, with exceptional response to NST, and a post-NST image-guided vacuum assisted biopsy showing no residual disease (ypT0), who opted not to have breast surgery...
March 19, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38521965/emerging-measurements-for-tumor-infiltrating-lymphocytes-in-breast-cancer
#35
JOURNAL ARTICLE
Rongrong Wu, Yoshiya Horimoto, Masanori Oshi, Matthew G K Benesch, Thaer Khoury, Kazuaki Takabe, Takashi Ishikawa
Tumor-infiltrating lymphocytes are a general term for lymphocytes or immune cells infiltrating the tumor microenvironment. Numerous studies have demonstrated tumor-infiltrating lymphocytes to be robust prognostic and predictive biomarkers in breast cancer. Recently, immune checkpoint inhibitors, which directly target tumor-infiltrating lymphocytes, have become part of standard of care treatment for triple-negative breast cancer. Surprisingly, tumor-infiltrating lymphocytes quantified by conventional methods do not predict response to immune checkpoint inhibitors, which highlights the heterogeneity of tumor-infiltrating lymphocytes and the complexity of the immune network in the tumor microenvironment...
March 23, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38521935/botulinum-toxin-a-new-differential-diagnosis-for-a-lytic-bone-lesion
#36
JOURNAL ARTICLE
Yael Lefkovits, Lara Lipton
BACKGROUND: Botulinum toxin, produced by the Gram-positive anaerobe Clostridium botulinum, is composed of seven antigenic subtypes (A, B, C, D, E, F, and G). Currently, only Botulinum toxin type A, commonly referred to as "Botox," is approved for clinical use, given its relatively safe clinical profile. Botulinum toxin type A has a wide range of therapeutic indications, including treatment for dystonia, migraine headache, neurogenic bladder, and large muscle spastic disorders. However, the toxin is most widely known for its cosmetic effects in treating wrinkles and facial lines...
March 24, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38521613/interdisciplinary-approach-to-expedited-outpatient-gastrostomy-tube-placement-in-head-and-neck-cancer-patients-a-single-center-retrospective-study
#37
JOURNAL ARTICLE
Pearce B Haldeman, Mansur A Ghani, Patricia Rubio, Minette Pineda, Joseph Califano, Assuntina G Sacco, Jeet Minocha, Zachary T Berman
RATIONALE AND OBJECTIVE: Treatment for head and neck cancer (HNC) can lead to decreased oral intake which often requires gastrostomy tube (g-tube) placement to provide nutritional support. A multidisciplinary team (MDT) consisting of interventional radiology (IR), HNC oncology and surgery, nutrition, and speech language pathology departments implemented an expedited outpatient g-tube placement pathway to reduce hospital stays and associated costs, initiate feeds sooner, and improve communication between care teams...
March 22, 2024: Academic Radiology
https://read.qxmd.com/read/38521421/palliative-care-for-pediatric-urology
#38
JOURNAL ARTICLE
Oscar Li, Royce Lee, Renee D Boss, Ming-Hsien Wang
Palliative care in the field of urology has largely been limited to adult oncologic conditions. Although there is a plethora of established literature suggesting the advantageous impact of palliative care, there is limited integration of palliative care in adult urology. This underutilization is further exacerbated in pediatric urology, and palliative care in pediatric urology remains an underexplored area despite the prevalence of several life-limiting conditions in this patient population. This paper highlights the potential need for palliative care intervention in a variety of urologic conditions in the pediatric population, including congenital lower urinary tract obstruction, neurogenic bladder dysfunction, exstrophy-epispadias complex, and congenital bilateral renal agenesis...
March 21, 2024: Journal of Pain and Symptom Management
https://read.qxmd.com/read/38520756/how-reliable-is-assessment-of-true-vocal-cord-arytenoid-unit-mobility-in-patients-affected-by-laryngeal-cancer-a-multi-institutional-study-on-366-patients-from-the-aryfix-collaborative-group
#39
JOURNAL ARTICLE
M Ferrari, F Mularoni, S Taboni, E Crosetti, C Pessina, A L C Carobbio, N Montalto, F Marchi, A Vural, A Paderno, S Caprioli, P Gaudioso, M Fermi, F Rigoni, T Saccardo, G Contro, A Ruaro, A Lo Manto, C Varago, M Baldovin, L Bandolin, M Filauro, C Sampieri, F Missale, A Ioppi, F Carta, M Ramanzin, M Ravanelli, V Maiolo, I Bertotto, F Del Bon, D Lancini, C Mariani, V Marrosu, M Tatti, S Cağlı, I Yüce, M Gündoğ, S Dogan, G Anile, C Gottardi, F Busato, A Vallin, F Gennarini, P Bossi, M G Ghi, M Lionello, E Zanoletti, G Marioni, R Maroldi, F Mattioli, R Puxeddu, A Bertolin, L Presutti, C Piazza, G Succo, G Peretti, P Nicolai
PURPOSE: In clinical practice the assessment of the "vocal cord-arytenoid unit" (VCAU) mobility is crucial in the staging, prognosis, and choice of treatment of laryngeal squamous cell carcinoma (LSCC). The aim of the present study was to measure repeatability and reliability of clinical assessment of VCAU mobility and radiologic analysis of posterior laryngeal extension. METHODS: In this multi-institutional retrospective study, patients with LSCC-induced impairment of VCAU mobility who received curative treatment were included; pre-treatment endoscopy and contrast-enhanced imaging were collected and evaluated by raters...
March 22, 2024: Oral Oncology
https://read.qxmd.com/read/38520583/sarcoma-size-and-limb-dimensions-predict-complications-recurrence-and-death-in-patients-with-soft-tissue-sarcoma-in-the-thigh-a-multidimensional-analysis
#40
JOURNAL ARTICLE
Rami Elmorsi, Luis Camacho, David D Krijgh, Gordon S Tilney, Heather Lyu, Raymond S Traweek, Russell G Witt, Margaret S Roubaud, Christina L Roland, Alexander F Mericli
BACKGROUND: Limb-sparing resections of thigh soft tissue sarcomas (STSs) can result in adverse outcomes. Identifying preoperative predictors for wound healing complications, tumor recurrence, and mortality is crucial for informed reconstructive decision-making. We hypothesized that preoperative measurements of thigh and tumor dimensions could serve as reliable indicators for postoperative complications, recurrence, and death. PATIENTS AND METHODS: In this retrospective cohort study conducted from March 2016 to December 2021, we analyzed patients undergoing thigh STS excisions followed by reconstruction...
March 23, 2024: Annals of Surgical Oncology
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