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https://www.readbyqxmd.com/read/29924369/precision-oncology-in-the-era-of-radiogenomics-the-case-of-d-2hg-as-an-imaging-biomarker-for-mutant-idh-gliomas
#1
Ovidiu C Andronesi
No abstract text is available yet for this article.
June 18, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29923622/advances-in-the-computational-and-molecular-understanding-of-the-prostate-cancer-cell-nucleus
#2
Neil M Carleton, George Lee, Anant Madabhushi, Robert W Veltri
Nuclear alterations are a hallmark of many types of cancers, including prostate cancer (PCa). Recent evidence shows that subvisual changes, ones that may not be visually perceptible to a pathologist, to the nucleus and its ultrastructural components can precede visual histopathological recognition of cancer. Alterations to nuclear features, such as nuclear size and shape, texture, and spatial architecture, reflect the complex molecular-level changes that occur during oncogenesis. Quantitative nuclear morphometry, a field that uses computational approaches to identify and quantify malignancy-induced nuclear changes, can enable a detailed and objective analysis of the PCa cell nucleus...
June 20, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29923514/whole-body-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-18-f-fdg-pet-ct-for-staging-locally-advanced-breast-cancer-a-prospective-study-from-a-tertiary-cancer-centre-in-south-india
#3
Sivanath Reddy Gajjala, Narendra Hulikal, Silpa Kadiyala, Radhika Kottu, Tekchand Kalawat
Background & objectives: Locally advanced breast cancer (LABC) is associated with substantial risk of occult metastases. The patients with LABC have high rate of systemic relapse, suggesting inadequacy of the current conventional staging in detecting the occult metastatic spread. 18 F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) is a new modality in the staging of breast cancer patients. Hence, this study was conducted to evaluate the role of 18 F-FDG PET/CT in initial staging of LABC and to compare it with conventional methods...
March 2018: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29923085/characterization-of-adrenal-lesions-using-mdct-wash-out-parameters-diagnostic-accuracy-of-several-combinations-of-intermediate-and-delayed-phases
#4
Giovanni Foti, Giuseppe Malleo, Niccolò Faccioli, Andrea Guerriero, Lino Furlani, Giovanni Carbognin
PURPOSE: To evaluate the diagnostic accuracy of wash-out parameters calculated using multiple intermediate and delayed phases. MATERIALS AND METHODS: This prospective study had institutional review board approval and informed consent was obtained from all patients. Between January 2012 and October 2016, 108 consecutive oncologic patients (59 males, 49 females, mean age 52.6 years; 129 diagnosed lesions) underwent multiphasic CT protocol including unenhanced (UE), arterial (AE), portal (PE), 5-min (DE-5) and the 15-min (DE-15) delayed phases of adrenal glands...
June 19, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29916118/emerging-intraoperative-imaging-modalities-to-improve-surgical-precision
#5
Israt S Alam, Idan Steinberg, Ophir Vermesh, Nynke S van den Berg, Eben L Rosenthal, Gooitzen M van Dam, Vasilis Ntziachristos, Sanjiv S Gambhir, Sophie Hernot, Stephan Rogalla
Intraoperative imaging (IOI) is performed to guide delineation and localization of regions of surgical interest. While oncological surgical planning predominantly utilizes x-ray computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound (US), intraoperative guidance mainly remains on surgeon interpretation and pathology for confirmation. Over the past decades however, intraoperative guidance has evolved significantly with the emergence of several novel imaging technologies, including fluorescence-, Raman, photoacoustic-, and radio-guided approaches...
June 18, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29913252/quantitative-imaging-for-radiation-oncology
#6
Uulke A van der Heide, Daniela Thorwarth
No abstract text is available yet for this article.
June 15, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29912434/evidence-based-optimization-of-post-treatment-surveillance-for-skull-base-chordomas-based-on-local-and-distant-disease-progression
#7
Jacob L Freeman, Ascher B Kaufmann, Richard G Everson, Franco DeMonte, Shaan M Raza
BACKGROUND: There are no guidelines regarding post-treatment surveillance specific to skull base chordomas. OBJECTIVE: To determine an optimal imaging surveillance schedule to detect both local and distant metastatic skull base chordoma recurrences. METHODS: A retrospective review of 91 patients who underwent treatment for skull base chordoma between 1993 and 2017 was conducted. Time to and location of local and distant recurrence(s) were cataloged...
April 18, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29912273/evaluation-of-retropectoral-fat-grafting-in-breast-reduction-by-magnetic-resonance-imaging-a-pilot-study
#8
Paulo Afonso Monteiro Pacheco Guimarães, Miguel Sabino Neto, Fabiana Claudino Lage, Fernanda Ferreira Guirado, Giselle Guedes Netto de Mello, Lydia Masako Ferreira
Background: One of the challenges in breast reduction is to maintain breast projection with 45% of its volume in the upper pole and 55% in the lower pole. Although widely used in breast surgeries, the behavior of fat grafts is still not completely understood. Objectives: To evaluate by magnetic resonance imaging (MRI) the survival of fat transferred to the retropectoral plane in patients undergoing breast reduction, in the search for an oncologically safe procedure with high predictability and reproducibility...
June 15, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29910831/postoperative-radiotherapy-after-nipple-or-skin-sparing-mastectomy-a-review-of-recent-institutional-and-pooled-data
#9
REVIEW
Jacques Bernier
The increasing use of nipple-sparing mastectomy (NSM) and skin-sparing mastectomy (SSM) in the treatment of nonmetastatic breast cancer is justified by considerations linked to their therapeutic index. In selected patients, efficacy results tend to be similar to those observed after radical modified mastectomy and at the same time, subcutaneous mastectomies preserve the patient's body image. Yet the oncologic safety of the two former surgical approaches is still a matter of debate, also in consideration of the almost complete absence of clinical studies directed to prospective, controlled comparisons between subcutaneous and radical modified mastectomies...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29908379/simultaneous-supratentorial-and-infratentorial-pilocytic-astrocytoma-in-an-adult-patient-with-concurrent-neurofibromatosis-type-1-and-hiv-infection
#10
Dalila Forte, Anabela Nabais, Carlos Pontinha, Manuela Mafra, Luís Mateus
BACKGROUND: Neurofibromatosis type 1 (NF1) is a tumour predisposing condition, being Pilocytic Astrocytomas (PA) a common benign central nervous system (CNS) tumour occurring in this setting. Although this is a common association, simultaneous development of multiple lesions is an infrequent finding, especially in non-optic or hypothalamic locations. CLINICAL CASE: A 41 year-old female patient with neurofibromatosis type 1 and uncontrolled human immunodeficiency virus (HIV) type 1 infection presents with a first generalized seizure and associated headache and ataxia...
June 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29907507/nrg-oncology-medical-physicists-manpower-survey-quantifying-support-demands-for-multi-institutional-clinical-trials
#11
James I Monroe, Karan Boparai, Ying Xiao, David Followill, James M Galvin, Eric E Klein, Daniel A Low, Jean M Moran, Haoyu Zhong, Jason W Sohn
PURPOSE: A survey was created by NRG to assess a medical physicists' percent full time equivalent (FTE) contribution to multi-institutional clinical trials. A 2012 American Society for Radiation Oncology report, "Safety Is No Accident," quantified medical physics staffing contributions in FTE factors for clinical departments. No quantification of FTE effort associated with clinical trials was included. METHODS: To address this lack of information, the NRG Medical Physics Subcommittee decided to obtain manpower data from the medical physics community to quantify the amount of time medical physicists spent supporting clinical trials...
February 4, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29907475/radiotherapy-for-langerhans-cell-histiocytosis-with-paraplegia-a-rare-oncologic-emergency-case-report-in-infancy-and-literature-review
#12
Kentaro Nakashima, Yuhki Koga, Yasunari Sakai, Hidetoshi Takada, Katsumi Harimaya, Saiji Ohga, Tomoaki Taguchi, Yoshinao Oda, Hiroshi Honda, Shouichi Ohga
BACKGROUND: Langerhans cell histiocytosis (LCH) is a clonal disease with focal or disseminated lesions that may compress the surrounding tissues, including the spinal cord. Because few reports have described the spinal symptoms as the first manifestation of pediatric LCH, the long-term neurological outcomes remain unclear. CASE REPORT AND LITERATURE REVIEW: We report a 21-month-old boy who presented with sudden-onset paraplegia. Imaging analyses revealed that osteolytic lesions and epidural tumors compressing the spinal cord at the T7-9 vertebrae...
June 12, 2018: Brain & Development
https://www.readbyqxmd.com/read/29907338/artificial-intelligence-in-radiation-oncology-a-specialty-wide-disruptive-transformation
#13
REVIEW
Reid F Thompson, Gilmer Valdes, Clifton D Fuller, Colin M Carpenter, Olivier Morin, Sanjay Aneja, William D Lindsay, Hugo J W L Aerts, Barbara Agrimson, Curtiland Deville, Seth A Rosenthal, James B Yu, Charles R Thomas
Artificial intelligence (AI) is emerging as a technology with the power to transform established industries, and with applications from automated manufacturing to advertising and facial recognition to fully autonomous transportation. Advances in each of these domains have led some to call AI the "fourth" industrial revolution [1]. In healthcare, AI is emerging as both a productive and disruptive force across many disciplines. This is perhaps most evident in Diagnostic Radiology and Pathology, specialties largely built around the processing and complex interpretation of medical images, where the role of AI is increasingly seen as both a boon and a threat...
June 12, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29904738/implications-for-high-precision-dose-radiation-therapy-planning-or-limited-surgical-resection-after-percutaneous-computed-tomography-guided-lung-nodule-biopsy-using-a-tract-sealant
#14
Patricia M de Groot, Girish S Shroff, Judy Ahrar, Bradley S Sabloff, Garret M Gladish, Cesar Moran, Sanjay Gupta, Gregory W Gladish, Joe Y Chang, Jeremy J Erasmus
Purpose: Precision radiation therapy such as stereotactic body radiation therapy and limited resection are being used more frequently to treat intrathoracic malignancies. Effective local control requires precise radiation target delineation or complete resection. Lung biopsy tracts (LBT) on computed tomography (CT) scans after the use of tract sealants can mimic malignant tract seeding (MTS) and it is unclear whether these LBTs should be included in the calculated tumor volume or resected...
April 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29903505/randomised-phase-ii-feasibility-trial-of-image-guided-external-beam-radiotherapy-with-or-without-high-dose-rate-brachytherapy-boost-in-men-with-intermediate-risk-prostate-cancer-cctg-pr15-nct01982786
#15
E Vigneault, G Morton, W R Parulekar, T M Niazi, C W Springer, M Barkati, P Chung, W Koll, A Kamran, M Monreal, K Ding, A Loblaw
AIMS: We conducted a multicentre feasibility study to assess the ability to randomise patients between image-guided radiotherapy (IGRT) and IGRT + high dose rate (HDR) brachytherapy boost and to adhere to appropriate radiation quality assurance standards. MATERIALS AND METHODS: The primary end point was to determine the ability to randomise 60 patients over an 18 month period. Arm 1 (IGRT) patients received 78 Gy in 39 fractions or 60 Gy in 20 fractions (physician's preference), whereas arm 2 (IGRT + HDR) received 37...
June 11, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29893309/breast-specific-functional-and-symptom-analysis-in-female-breast-cancer-survivors
#16
Shaqul Qamar Wani, Talib Khan, Saiful Yamin Wani, Mohammad Ashraf Teli, Nazir Ahmad Khan, Liza Rafiq Mir, Mohammad Maqbool Lone, Fir Afroz
Context: The disease and surgery of the breast not only evoke a fear of mutilation and loss of feminity but is also responsible for psychosocial, behavioral, and sexual problems. Aim: To analyze prospectively the time trends in "breast specific functional and symptom scale scores in female breast cancer survivors." Settings and Design: The prospective study was conducted in the Department of Radiation Oncology at Tertiary Referral Hospital...
April 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29891263/treatment-design-and-rationale-for-a-randomized-trial-of-prophylactic-cranial-irradiation-with-or-without-hippocampal-avoidance-for-sclc-premer-trial-on-behalf-of-the-oncologic-group-for-the-study-of-lung-cancer-spanish-radiation-oncology-group-radiation-oncology
#17
Nuria Rodríguez de Dios, Felipe Couñago, José Luis López, Patricia Calvo, Mauricio Murcia, Mikel Rico, Carmen Vallejo, Javier Luna, Itziar Trueba, Cristina Cigarral, Nuria Farre, Rosa Maria Manero, Xavier Durán, Pilar Samper
BACKGROUND: Prophylactic cranial irradiation (PCI) is part of the usual treatment in most patients with small-cell lung cancer (SCLC) and response after treatment of the primary tumor. Clinical evidence suggests that radiation dose received by the hippocampus during whole brain radiotherapy might play a role in radiation-induced neurocognitive decline. PATIENTS AND METHODS: This study is a multicenter phase III trial (NCT02397733) randomizing SCLC patients after informed consent, to receive standard PCI treatment or PCI with hippocampus avoidance (PCI-HA) by using intensity modulated radiation therapy or volumetric modulated arc therapy...
May 10, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29889468/long-term-follow-up-results-of-concomitant-chemoradiotherapy-followed-by-adjuvant-temozolomide-therapy-for-glioblastoma-multiforme-patients-the-importance-of-mri-information-in-survival-single-center-experience
#18
Gábor Lukács, Zoltán Tóth, Dávid Sipos, Melinda Csima, Janaki Hadjiev, Gábor Bajzik, Zsolt Cselik, Dávid Semjén, Imre Repa, Árpád Kovács
Background and purpose: Glioblastoma multiforme (GBM) is the most common malignant primary anomaly of central nervous system. The GBM infiltrates the nearly sturctures from the initial tumor and its metastatic attribution is well known. The aim of our single-centered retrospective study was to introduce the importance of postoperative medical imaging confirmation of total tumor resection for patient with GBM combined concomitant and adjuvant chemoradiotherapy on a 10 year long patient follow up...
March 30, 2018: Ideggyógyászati Szemle
https://www.readbyqxmd.com/read/29889046/variations-of-quantitative-perfusion-measurement-on-dynamic-contrast-enhanced-ct-for-colorectal-cancer-implication-of-standardized-image-protocol
#19
Tianye Niu, Pengfei Yang, Xiaonan Sun, Tingyu Mao, Lei Xu, Ning Jeff Yue, Yu Kuang, Liming Shi, Ke Nie
Tumor angiogenesis is considered as an important prognostic factor. With an increasing emphasis on imaging evaluation of the tumor microenvironment, dynamic contrast enhanced (DCE) CT has evolved as an important functional technique in this setting. Yet many questions remain as how and when these functional measurements should be performed for each agent and tumor type, and what quantitative models should be used in the fitting process. In this study, we evaluated the variations of perfusion measurement on DCE-CT for rectal cancer patients from (1) different tracer kinetic models, (2) different scan acquisition lengths and (3) different scan intervals...
June 11, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29887184/percutaneous-cryoablation-of-solitary-sporadic-renal-cell-carcinoma-outcome-analysis-based-on-clear-cell-versus-papillary-subtypes
#20
Mustafa M Haddad, Grant D Schmit, A Nicholas Kurup, John J Schmitz, Stephen A Boorjian, Jennifer Geske, R Houston Thompson, Matthew R Callstrom, Thomas D Atwell
PURPOSE: To evaluate treatment outcomes with percutaneous cryoablation (PCA) based on renal cell carcinoma (RCC) histology. METHODS AND MATERIALS: Patients treated with PCA for a solitary, sporadic stage T1a RCC from 2003 to 2016 were identified from a single institution's renal ablation registry. Patients with multiple tumors, history of RCC, or genetic syndromes associated with RCC (n = 60); no specific RCC subtype determined from core biopsy (n = 66); RCC subtype other than clear-cell or papillary (n = 7); or less than 3 mo of follow-up imaging (n = 5) were excluded...
June 7, 2018: Journal of Vascular and Interventional Radiology: JVIR
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