Kamila Furtado da Cunha, Marcelle de Oliveira Garcia, Suzane Olachea Allend, Déborah Trota Farias de Albernaz, Bruno Nunes da Rosa, Isabel Ladeira Pereira, Cláudio Martin de Pereira de Pereira, Daiane Drawanz Hartwig
To find novel antibiotic drugs, six 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-1H derivatives named 1b, 1d (pyrazoles), 2a, 2b, 2c, and 2d (thiazoles) were evaluated in silico and in vitro. The in silico analyses were based on ADME pharmacokinetic parameters (absorption, distribution, metabolism, and excretion). The in vitro antibacterial activity was evaluated in Gram-positive and Gram-negative species (Staphylococcus aureus ATCC® 25904, Staphylococcus epidermidis ATCC® 35984, Klebsiella pneumoniae ATCC® 700603, and Acinetobacter baumannii ATCC® 19606), by determination of minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), kinetics curve, and antibiofilm assays...
September 1, 2023: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]