Antonie Lechner, Fiona D R Henkel, Franziska Hartung, Sina Bohnacker, Francesca Alessandrini, Ekaterina O Gubernatorova, Marina S Drutskaya, Carlo Angioni, Yannick Schreiber, Pascal Haimerl, Yan Ge, Dominique Thomas, Agnieszka M Kabat, Edward J Pearce, Caspar Ohnmacht, Sergei A Nedospasov, Peter J Murray, Adam M Chaker, Carsten B Schmidt-Weber, Julia Esser-von Bieren
BACKGROUND: Infectious agents can reprogram or "train" macrophages and their progenitors to respond more readily to subsequent insults. However, whether such an inflammatory memory exists in type 2 inflammatory conditions such as allergic asthma was not known. OBJECTIVE: We sought to decipher macrophage-trained immunity in allergic asthma. METHODS: We used a combination of clinical sampling of house dust mite (HDM)-allergic patients, HDM-induced allergic airway inflammation in mice, and an in vitro training setup to analyze persistent changes in macrophage eicosanoid, cytokine, and chemokine production as well as the underlying metabolic and epigenetic mechanisms...
June 2022: Journal of Allergy and Clinical Immunology