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https://www.readbyqxmd.com/read/29331705/catechol-o-methyltransferase-comt-functional-haplotype-is-associated-with-recurrence-of-affective-symptoms-a-prospective-birth-cohort-study
#1
Shinsuke Koike, Darya Gaysina, Peter B Jones, Andrew Wong, Marcus Richards
BACKGROUND: Catechol-O-methyltransferase (COMT) polymorphisms play an essential role in dopamine availability in the brain. However, there has been no study investigating whether a functional four-SNP (rs6269-rs4633-rs4818-rs4680) haplotype is associated with affective symptoms over the life course. METHODS: We tested this using 2093 members of the Medical Research Council National Survey of Health and Development (MRC NSHD), who had been followed up since birth in 1946, and had data for COMT genotypes, adolescent emotional problems (age 13-15) and at least one measure of adult affective symptoms at ages 36, 43, 53, or 60-64 years...
January 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29319456/comt-genotype-and-sensory-and-sensorimotor-gating-in-high-and-low-hypnotizable-subjects
#2
Zinaida I Storozheva, Anna V Kirenskaya, Mikhail N Gordeev, Maria E Kovaleva, Vladimir Yu Novototsky-Vlasov
We investigated the association between hypnotizability, COMT polymorphism, P50 suppression ratio, and prepulse inhibition of acoustic startle response (ASR) in 21 high (HH) and 19 low (LH) hypnotizable subjects. The frequency of Met/Met carriers of COMT polymorphysm was higher in HH than in LH group (33.3% versus 10.6%, p = .049). Increased ASR amplitude and latency and decreased prepulse inhibition at 120 ms lead interval were found in the HH compared to the LH group. The effect of COMT genotype on prepulse inhibition was observed in LH group only...
January 2018: International Journal of Clinical and Experimental Hypnosis
https://www.readbyqxmd.com/read/29314589/effect-of-the-comt-val158met-genotype-on-lateral-prefrontal-activations-in-young-children
#3
Yusuke Moriguchi, Ikuko Shinohara
Low executive function (EF) during early childhood is a major risk factor for developmental delay, academic failure, and social withdrawal. Susceptible genes may affect the molecular and biological mechanisms underpinning EF. More specifically, genes associated with the regulation of prefrontal dopamine may modulate the response of prefrontal neurons during executive control. Several studies with adults and older children have shown that variants of the catechol-O-methyltransferase (COMT) gene are associated with behavioral performance and prefrontal activations in EF tasks...
January 4, 2018: Developmental Science
https://www.readbyqxmd.com/read/29259946/genetic-analysis-of-mu-and-kappa-opioid-receptor-and-comt-enzyme-in-cancer-pain-tunisian-patients-under-opioid-treatment
#4
Imen Chatti, Jean-Baptiste Woillard, Amira Mili, Isabelle Creveaux, Ilhem Ben Charfeddine, Jihène Feki, Sarah Langlais, Leila Ben Fatma, Ali Saad, Moez Gribaa, Frédéric Libert
Background: Pain and its opioid treatments are complex measurable traits. Responses to morphine in terms of pain control is likely to be determined by many factors, including the underlying pain sensitivity of the patient, along with nature and extent of the painful process, concomitant medications, genetic and other clinical and environmental factors. This study investigated genetic polymorphisms implicated in the inter-individual pain response variability to opioid treatment in the Tunisian population...
December 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29248614/significant-association-between-catechol-o-methyltransferase-comt-val158-108met-polymorphism-and-cognitive-function-in-veterans-with-ptsd
#5
Ana Havelka Mestrovic, Lucija Tudor, Matea Nikolac Perkovic, Gordana Nedic Erjavec, Zrnka Kovacic Petrovic, Dubravka Svob Strac, Marcela Konjevod, Nela Pivac
Core features of posttraumatic stress disorder (PTSD) are cognitive disturbances. Enzyme catechol-O-methyltransferase (COMT) degrades dopamine primarily in prefrontal cortex. Its functional polymorphism, COMT Val158/108Met, affects COMT activity and dopamine availability and is associated with disturbances in cognition. The hypothesis was that PTSD subjects will have worse working memory than healthy controls and that the carriers of the COMT Met allele will show better cognitive performance compared to Val/Val carriers in PTSD and controls subjects...
December 14, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29247072/vascular-and-dopaminergic-contributors-to-mild-parkinsonian-signs-in-older-adults
#6
Andrea L Rosso, Nicolaas I Bohnen, Lenore J Launer, Howard J Aizenstein, Kristine Yaffe, Caterina Rosano
OBJECTIVE: Mild parkinsonian signs (MPS) are an underappreciated neurologic condition in older adults; we assessed associations of MPS with measures of dopaminergic (catechol-O-methyltransferase [COMT] genotype, an indicator of synaptic dopamine levels) and vascular (white matter hyperintensities [WMH], an indicator of cerebral small vessel disease) factors. METHODS: In a cohort of older adults (mean age 82.6 years [SD 2.6]; 58.0% female; 38.8% black), we assessed cross-sectional associations of WMH volume and COMT Val158Met (rs4680) genotype (n = 35 Met/Met, n = 180 Val carriers) with MPS by regression models adjusted for demographic and health characteristics...
December 15, 2017: Neurology
https://www.readbyqxmd.com/read/29222971/the-divergent-impact-of-catechol-o-methyltransferase-comt-val158met-genetic-polymorphisms-on-executive-function-in-adolescents-with-discrete-patterns-of-childhood-adversity
#7
Huihui Zhang, Jie Li, Bei Yang, Tao Ji, Zhouting Long, Qiquan Xing, Di Shao, Huayu Bai, Jiwei Sun, Fenglin Cao
PURPOSE: Catechol-O-methyltransferase (COMT) Val158Met functional polymorphisms play a crucial role in the development of executive function (EF), but their effect may be moderated by environmental factors such as childhood adversity. The present study aimed at testing the divergent impact of the COMT Val158Met genotype on EF in non-clinical adolescents with discrete patterns of childhood adversity. METHODS: A total of 341 participants completed the Childhood Trauma Questionnaire, the self-reported version of the Behavior Rating Inventory of Executive Function, and self-administered questionnaires on familial function...
November 22, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29222686/eeg-source-imaging-indices-of-cognitive-control-show-associations-with-dopamine-system-genes
#8
G McLoughlin, J Palmer, S Makeig, N Bigdely-Shamlo, T Banaschewski, M Laucht, D Brandeis
Cognitive or executive control is a critical mental ability, an important marker of mental illness, and among the most heritable of neurocognitive traits. Two candidate genes, catechol-O-methyltransferase (COMT) and DRD4, which both have a roles in the regulation of cortical dopamine, have been consistently associated with cognitive control. Here, we predicted that individuals with the COMT Met/Met allele would show improved response execution and inhibition as indexed by event-related potentials in a Go/NoGo task, while individuals with the DRD4 7-repeat allele would show impaired brain activity...
December 8, 2017: Brain Topography
https://www.readbyqxmd.com/read/29201551/investigation-of-the-comt-val158met-variant-association-with-age-of-onset-of-psychosis-adjusting-for-cannabis-use
#9
Rohit J Lodhi, Yabing Wang, David Rossolatos, Georgina MacIntyre, Alexandra Bowker, Candice Crocker, Hongyan Ren, Aleksandra Dimitrijevic, Darren A Bugbee, Alexandra Loverock, Brett Majeau, Sudhakar Sivapalan, Virginia M Newton, Philip Tibbo, Scot E Purdon, Katherine J Aitchison
Objective: COMT rs4680 (Val158Met) genotype moderates the effect of cannabis on the age of onset of psychosis (AoP). We investigated the association between rs4680 and AoP, after adjusting for relevant covariates, in a Canadian Caucasian sample. Methods: One hundred and sixty-nine subjects with psychosis were recruited. AoP, defined as age of DSM-IV diagnosis was established using the Structured Clinical Interview for DSM-IV. Cannabis use data were collected using a self-report computerized questionnaire...
November 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29198511/preliminary-evidence-for-an-association-between-variants-of-the-catechol-o-methyltransferase-comt-gene-and-premature-ejaculation
#10
Patrick Jern, Ada Johansson, Jana Strohmaier, Jens Treutlein, Juhana Piha, Marcella Rietschel
BACKGROUND: Studies have suggested that dopamine plays a role in the neurobiological mechanism that triggers ejaculation, leading scientists to hypothesize that dopamine-related genetic polymorphisms could contribute to symptoms of premature ejaculation (PE). AIM: To investigate associations between dopamine receptor and catechol-O-methyltransferase (COMT; an enzyme involved in the catabolism of dopamine) gene-linked polymorphisms and PE. METHODS: PE status in patient groups was determined by clinical diagnosis performed by a physician specializing in sexual medicine...
December 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29194954/comt-val158-met-moderates-the-link-between-rank-and-aggression-in-a-non-human-primate
#11
Daria Raffaella Gutleb, Christian Roos, Angela Noll, Julia Ostner, Oliver Schülke
The COMT Val158 Met polymorphism is one of the most widely studied genetic polymorphisms in humans implicated in aggression and the moderation of stressful life event effects. We screened a wild primate population for polymorphisms at the COMT Val158 Met site and phenotyped them for aggression to test whether the human polymorphism exists and is associated with variation in aggressive behavior. Subjects were all adults from four study groups (37 males, 40 females) of Assamese macaques (Macaca assamensis) in their natural habitat (Phu Khieo Wildlife Sanctuary, Thailand)...
December 1, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29154367/effects-of-amphetamine-on-sensorimotor-gating-and-neurocognition-in-antipsychotic-medicated-schizophrenia-patients
#12
Neal R Swerdlow, Savita G Bhakta, Jo A Talledo, Daniel M Franz, Erica L Hughes, Brinda K Rana, Gregory A Light
Prepulse inhibition (PPI) of startle is being explored both as an indicator of target engagement for, and a biomarker predicting sensitivity to, pro-cognitive effects of drugs. We now report the effects of the pro-attentional drug, d-amphetamine, on PPI and neurocognition in antipsychotic-medicated schizophrenia patients and healthy subjects (HS) who were also tested in a targeted cognitive training (TCT) module. 44 HS and 38 schizophrenia patients completed a double-blind, placebo-controlled crossover study of the effects of a single dose of amphetamine (10 mg po) on PPI and MATRICS Consensus Cognitive Battery (MCCB) performance; TCT results were previously reported from 60 of these subjects...
November 20, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29135816/dopaminergic-genetic-variants-and-voluntary-externally-paced-exercise-behavior
#13
Denise J van der Mee, Iryna O Fedko, Jouke-Jan Hottenga, Erik A Ehli, Matthijs D van der Zee, Lannie Ligthart, Toos C E M van Beijsterveldt, Gareth E Davies, Meike Bartels, Joseph G Landers, Eco J C de Geus
PURPOSE: Most candidate gene studies on the neurobiology of voluntary exercise behavior have focused on the dopaminergic signaling pathway and its role in the mesolimbic reward system. We hypothesized that dopaminergic candidate genes may influence exercise behavior through additional effects on executive functioning and that these effects are only detected when the types of exercise activity are taken into account. METHODS: Data on voluntary exercise behavior and at least one SNP/VNTR were available for 12,929 participants of the Netherlands Twin Registry...
November 9, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29044248/task-demands-tdcs-intensity-and-the-comt-val-158-met-polymorphism-impact-tdcs-linked-working-memory-training-gains
#14
Jaclyn A Stephens, Kevin T Jones, Marian E Berryhill
Working memory (WM) training paired with transcranial direct current stimulation (tDCS) can improve executive function in older adults. The unclear mechanism of tDCS likely depends on tDCS intensity, and task relevant genetic factors (e.g., for WM: COMT val(158)met, DAT, BDNF val(66)met). Higher tDCS intensity does not always lead to greater cognitive gains, and genetic polymorphisms may modulate tDCS-linked WM improvements. To evaluate these factors, 137 healthy older adults provided DNA samples and received Visual and Spatial WM training paired with tDCS (sham, 1, 1...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038017/fetal-growth-interacts-with-multilocus-genetic-score-reflecting-dopamine-signaling-capacity-to-predict-spontaneous-sugar-intake-in%C3%A2-children
#15
Patrícia P Silveira, Irina Pokhvisneva, Hélène Gaudreau, Leslie Atkinson, Alison S Fleming, Marla B Sokolowski, Meir Steiner, James L Kennedy, Laurette Dubé, Robert D Levitan, Michael J Meaney
BACKGROUND: We have shown that intrauterine growth restriction (IUGR) leads to increased preference for palatable foods at different ages in both humans and rodents. In IUGR rodents, altered striatal dopamine signaling associates with a preference for palatable foods. OBJECTIVES: Our aim was to investigate if a multilocus genetic score reflecting dopamine-signaling capacity is differently associated with spontaneous palatable food intake in children according to the fetal growth status...
January 1, 2018: Appetite
https://www.readbyqxmd.com/read/28968343/influence-of-catechol-o-methyltransferase-val158met-on-fear-of-pain-and-placebo-analgesia
#16
June T Forsberg, Johannes Gjerstad, Magne Arve Flaten, Per M Aslaksen
Higher levels of fear have been shown to partly explain individual differences in placebo analgesic responding. The catechol-O-methyltransferase (COMT) rs4680 Val158Met polymorphism has been associated with both increased placebo analgesia and increased fear-related behavior, in what appears to be inconsistent findings in the literature. The aim of the study was therefore to investigate placebo analgesia and fear-related processes with regard to the COMT genotype, to sort out whether the Met-allele is associated with increased placebo analgesia or increased fear of pain (FOP)...
October 30, 2017: Pain
https://www.readbyqxmd.com/read/28968204/prevalence-of-comt-val158met-polymorphism-in-eastern-up-population
#17
P Kumar, U Yadav, V Rai
Catechol-O-methyltransferase (COMT) is an abundant S-adenosylmethionine (SAM-)-dependent methyltransferase that methylates catechol compounds, including catecholamines and catecholestrogens.COMT  gene located at chromosome 22q11.2 contains a functional polymorphism at codon 158(Val158Met), which has been related to psychiatric diseases and different types of cancer. COMT might affect tHcy levels because as a by-product it converts SAM to S-adenosylhomocysteine (SAH), which is reversibly converted to homocysteine...
July 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28948081/sex-specific-effects-of-comt-val158met-polymorphism-on-corpus-callosum-structure-a-whole-brain-diffusion-weighted-imaging-study
#18
Wissam El-Hage, Helen Cléry, Frederic Andersson, Isabelle Filipiak, Michel Thiebaut de Schotten, Benedicte Gohier, Simon Surguladze
BACKGROUND: Genetic polymorphisms play a significant role in determining brain morphology, including white matter structure and may thus influence the development of brain functions. The main objective of this study was to examine the effect of Val158Met (rs4680) polymorphism of Catechol-O-Methyltransferase (COMT) gene on white matter connectivity in healthy adults. METHODS: We used a whole-brain diffusion-weighted imaging method with Tract-Based Spatial Statistics (TBSS) analysis to examine white matter structural integrity in intrinsic brain networks on a sample of healthy subjects (N = 82)...
September 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28928973/prospective-replication-study-implicates-the-catechol-o-methyltransferase-val-158-met-polymorphism-as-a-biomarker-for-the-response-to-morphine-in-patients-with-cancer
#19
Hiromichi Matsuoka, Chihiro Makimura, Atsuko Koyama, Yoshihiko Fujita, Junji Tsurutani, Kiyohiro Sakai, Ryo Sakamoto, Kazuto Nishio, Kazuhiko Nakagawa
Genetic differences in humans cause clinical difficulties in opioid treatment. Previous studies indicate that a single nucleotide polymorphism in the catechol-O-methyltransferase (COMT) gene (rs4680; p.Val(158)Met) may present as a predictive biomarker for the response to morphine treatment. In our previous pilot exploratory study, patients with a G/G genotype were demonstrated to require a higher dose of morphine, compared with patients with A/A and A/G genotypes. In the present study, the aim was to replicate the findings in an independent cohort of opioid-treatment-naïve patients exhibiting various types of cancer...
October 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28913946/facial-emotion-recognition-in-schizophrenia-an-exploratory-study-on-the-role-of-comorbid-alcohol-and-substance-use-disorders-and-comt-val158met
#20
Giuseppe Carrà, Gabriella Nicolini, Annamaria Lax, Francesco Bartoli, Filippo Castellano, Alessia Chiorazzi, Giulia Gamba, Mattia Bava, Cristina Crocamo, Costanza Papagno
OBJECTIVES: To explore whether facial emotion recognition (FER), impaired in both schizophrenia and alcohol and substance use disorders (AUDs/SUDs), is additionally compromised among comorbid subjects, also considering the role of catechol-O-methyltransferase (COMT) Val158Met. METHODS: We conducted a cross-sectional study, randomly recruiting 67 subjects with a DSM-IV-TR diagnosis of schizophrenia, and rigorously assessing AUDs/SUDs and COMT Val158Met polymorphism...
September 15, 2017: Human Psychopharmacology
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