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COMT met/met

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https://www.readbyqxmd.com/read/27898499/comt-and-bdnf-gene-variants-help-to-predict-alcohol-consumption-in-alcohol-dependent-patients
#1
Anna Klimkiewicz, Anna Mach, Andrzej Jakubczyk, Jakub Klimkiewicz, Anna Wnorowska, Maciej Kopera, Sylwia Fudalej, Margit Burmeister, Kirk Brower, Marcin Wojnar
BACKGROUND: The neurobiology of alcohol dependence (AD) involves alterations in neurotransmitters and the stress response. We hypothesized that an interaction between functional variants of dopaminergic and neurotrophic genes may influence drinking in AD. METHODS: The relationship between alcohol consumption and single-nucleotide polymorphisms, Val66Met in the brain-derived neurotrophic factor (BDNF), and Val158Met in the catechol-O-methyltransferase (COMT), was analyzed among 281 alcohol-dependent individuals...
November 24, 2016: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/27836240/influence-of-comt-val-158-met-polymorphism-on-emotional-decision-making-a-sex-dependent-relationship
#2
Danielle de Souza Costa, Antoine Bechara, Jonas Jardim de Paula, Marco Aurélio Romano-Silva, Humberto Correa, Guilherme Menezes Lage, Débora Marques de Miranda, Leandro Fernandes Malloy-Diniz
The biological underpinnings of sex-related differences in decision-making are still under-explored. The COMT gene is related to sexual dimorphism and with different choices made under uncertainty, albeit no study has specifically investigated a moderation effect of sex on the association between the COMT gene and the performance on decision-making paradigms. In this study, we investigated the influence of the COMT Val(158)Met polymorphism on Iowa Gambling Task (IGT) performance depending on sex in a healthy adult sample...
November 1, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27825784/does-comt-val158met-polymorphism-influence-p50-sensory-gating-eye-tracking-or-saccadic-inhibition-dysfunctions-in-schizophrenia
#3
Caroline Demily, Sandrine Louchart-de-la-Chapelle, Irène Nkam, Nicolas Ramoz, Pierre Denise, Alain Nicolas, Caroline Savalle, Florence Thibaut
Three electrophysiological endophenotypes are routinely studied in schizophrenia (SCZ): smooth pursuit eye movement (SPEM) dysfunction, deficits in P50 auditory-evoked potential inhibition, and saccadic inhibition deficits. The current study aimed to investigate the relationship between the COMT val158met polymorphism and these three endophenotypes. One hundred four SCZ patients (DSM-IV-R criteria) and 89 healthy controls were included in this study. P50 auditory-evoked potential inhibition, antisaccade paradigm and SPEM were analyzed...
October 27, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27793591/association-between-comt-genotype-and-the-control-of-memory-guided-saccades-individual-differences-in-healthy-adults-reveal-a-detrimental-role-of-dopamine
#4
Jutta Billino, Jürgen Hennig, Karl R Gegenfurtner
The neural circuits involved in oculomotor control are well described; however, neuromodulation of eye movements is still hardly understood. Memory guided saccades have been extensively studied and in particular neurophysiological evidence from monkey studies points to a crucial functional role of prefrontal dopamine activity. We exploited individual differences in dopamine regulation due to the well established COMT (catechol-O-methyltransferase) Val(158)Met polymorphism to explore the link between prefrontal dopamine activity and memory guided saccades in healthy subjects...
October 25, 2016: Vision Research
https://www.readbyqxmd.com/read/27785396/association-between-the-catechol-o-methyltransferase-val158met-polymorphism-with-susceptibility-and-severity-of-carpal-tunnel-syndrome
#5
E Erkol İnal, P Eroğlu, O Görükmez, Ş Özemri Sağ, T Yakut
Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy of the upper extremity. In this study, we aimed to clarify the relationships between the catechol-O-methyltransferase (COMT) gene Val158Met (rs4680) polymorphism and development, functional and clinical status of CTS. Ninety-five women with electro diagnostically confirmed CTS and 95 healthy controls were enrolled in the study. The functional and clinical status of the patients was measured by the Turkish version of the Boston Questionnaire and intensity of pain related to the past 2 weeks was evaluated on a visual analog scale (VAS)...
December 1, 2015: Balkan Journal of Medical Genetics: BJMG
https://www.readbyqxmd.com/read/27780702/catechol-o-methyltransferase-gene-polymorphism-and-vulvar-pain-in-women-with-vulvodynia
#6
Insiyyah Y Patanwala, Georgine Lamvu, William J Ledger, Kathryn Witzeman, Richard Marvel, Andrea Rapkin, Ann Marie Bongiovanni, Jessica Feranec, Steven S Witkin
BACKGROUND: The underlying causes of vulvar pain in women with vulvodynia remain poorly understood. Catechol-O-methyltransferase, an enzyme that metabolizes catecholamines, is a neuromodulator that is involved with perception and sensitivity to pain. The catechol-O-methyltransferase gene is polymorphic, and a single nucleotide polymorphism is associated with low activity and heightened pain sensitivity. The variant allele that encodes this polymorphism commonly is called the "L allele" because of its low enzyme activity as opposed to the normal H (high activity) allele...
October 22, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27769642/comt-val-158-met-polymorphism-is-associated-with-post-traumatic-stress-disorder-and-functional-outcome-following-mild-traumatic-brain-injury
#7
Ethan A Winkler, John K Yue, Adam R Ferguson, Nancy R Temkin, Murray B Stein, Jason Barber, Esther L Yuh, Sourabh Sharma, Gabriela G Satris, Thomas W McAllister, Jonathan Rosand, Marco D Sorani, Hester F Lingsma, Phiroz E Tarapore, Esteban G Burchard, Donglei Hu, Celeste Eng, Kevin K W Wang, Pratik Mukherjee, David O Okonkwo, Ramon Diaz-Arrastia, Geoffrey T Manley
Mild traumatic brain injury (mTBI) results in variable clinical trajectories and outcomes. The source of variability remains unclear, but may involve genetic variations, such as single nucleotide polymorphisms (SNPs). A SNP in catechol-o-methyltransferase (COMT) is suggested to influence development of post-traumatic stress disorder (PTSD), but its role in TBI remains unclear. Here, we utilize the Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot (TRACK-TBI Pilot) study to investigate whether the COMT Val(158)Met polymorphism is associated with PTSD and global functional outcome as measured by the PTSD Checklist - Civilian Version and Glasgow Outcome Scale Extended (GOSE), respectively...
October 18, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27744110/comtval158met-polymorphism-is-associated-with-behavioral-response-and-physiologic-reactivity-to-socio-emotional-stress-in-4-month-old-infants
#8
Rosario Montirosso, Livio Provenzi, Daniela Tavian, Sara Missaglia, Maria Elisabetta Raggi, Renato Borgatti
Individual variability exists in infants' socio-emotional stress regulation, in terms of behavioral response (i.e., negative emotionality) as well as magnitude and direction (i.e., increase or decrease) of hypothalamic-pituitary-adrenal (HPA) axis reactivity (i.e., salivary cortisol post-stress concentration). The catechol-O-methyltransferase polymorphism at codon 158 (COMTval158met) associates with stress regulation, but no evidence exists for infants. This study aimed to assess the association between COMTval158met and both negative emotionality and salivary cortisol reactivity to socio-emotional stress in 4-month-old infants...
October 12, 2016: Infant Behavior & Development
https://www.readbyqxmd.com/read/27685665/design-of-potent-and-druglike-nonphenolic-inhibitors-for-catechol-o-methyltransferase-derived-from-a-fragment-screening-approach-targeting-the-s-adenosyl-l-methionine-pocket
#9
Christian Lerner, Roland Jakob-Roetne, Bernd Buettelmann, Andreas Ehler, Markus Rudolph, Rosa María Rodríguez Sarmiento
A fragment screening approach designed to target specifically the S-adenosyl-l-methionine pocket of catechol O-methyl transferase allowed the identification of structurally related fragments of high ligand efficiency and with activity on the described orthogonal assays. By use of a reliable enzymatic assay together with X-ray crystallography as guidance, a series of fragment modifications revealed an SAR and, after several expansions, potent lead compounds could be obtained. For the first time nonphenolic and small low nanomolar potent, SAM competitive COMT inhibitors are reported...
October 14, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27683563/childhood-trauma-and-comt-genotype-interact-to-increase-hippocampal-activation-in-resilient-individuals
#10
Sanne J H van Rooij, Jennifer S Stevens, Timothy D Ely, Negar Fani, Alicia K Smith, Kimberly A Kerley, Adriana Lori, Kerry J Ressler, Tanja Jovanovic
Both childhood trauma and a functional catechol-O-methyltransferase (COMT) genetic polymorphism have been associated with posttraumatic stress disorder (PTSD) and depression; however, it is still unclear whether the two interact and how this interaction relates to long-term risk or resilience. Imaging and genotype data were collected on 73 highly traumatized women. DNA extracted from saliva was used to determine COMT genotype (Val/Val, n = 38, Met carriers, n = 35). Functional MRI data were collected during a Go/NoGo task to investigate the neurocircuitry underlying response inhibition...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27664968/prefrontal-volume-mediates-effect-of-comt-polymorphism-on-interference-resolution-capacity-in-healthy-male-adults
#11
Jiayuan Xu, Wen Qin, Qiaojun Li, Wei Li, Feng Liu, Bing Liu, Tianzi Jiang, Chunshui Yu
There exist gender differences in the modulation of catechol-O-methyltransferase (COMT) Val158Met polymorphism on cognitive performance; however, the underlying gene-anatomy-cognition pathways remain unknown. Here we hypothesize that prefrontal volume may mediate the modulation of COMT Val158Met polymorphism on interference resolution capacity in a gender-dependent manner. In 261 healthy young human subjects (143 males and 118 females), a 2-way analysis of variance showed a COMT × gender interaction (P = 0...
September 24, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27622935/evidence-that-comt-genotype-and-proline-interact-on-negative-symptom-outcomes-in-schizophrenia-and-bipolar-disorder
#12
C L Clelland, V Drouet, K C Rilett, J A Smeed, R H Nadrich, A Rajparia, L L Read, J D Clelland
Elevated peripheral proline is associated with psychiatric disorders, and there is evidence that proline is a neuromodulator. The proline dehydrogenase (PRODH) gene, which encodes the enzyme that catalyzes proline catabolism, maps to human chromosome 22q11.2, a region conferring risk of schizophrenia. In the Prodh-null mouse, an interaction between elevated peripheral proline and another 22q11.2 gene, catechol-O-methyltransferase (COMT), on neurotransmission and behavior has been reported. We explored the relationship between fasting plasma proline levels and COMT Val(158)Met genotype on symptoms (positive, negative and total) in schizophrenia patients...
September 13, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27619075/iq-and-hemizygosity-for-the-val-158-met-functional-polymorphism-of-comt-in-22q11ds
#13
Colleen P Franconi, Donna McDonald-McGinn, Elaine H Zackai, Meghan A McNamara, Harold Salmons, Edward Moss, Raquel E Gur, Marcella Devoto, Beverly S Emanuel
22q11.2 Deletion Syndrome (22q11DS) is a multisystem disorder caused by a hemizygous deletion within 22q11.2. Patients with the deletion display a wide range of cognitive deficits. The gene catechol-O-methyl-transferase (COMT) resides in the typically deleted region of 22q11.2 and is rendered hemizygous in individuals affected by the 22q11DS. COMT is a critical enzyme in the degradation of catecholamine neurotransmitters in the brain. A functional polymorphism, Val(158) Met, has been associated with a variety of neurocognitive outcomes...
December 2016: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/27522491/catechol-o-methyltransferase-comt-gene-modulates-private-self-consciousness-and-self-flexibility
#14
Bei Wang, Wenzhao Ru, Xing Yang, Lu Yang, Pengpeng Fang, Xu Zhu, Guomin Shen, Xiaocai Gao, Pingyuan Gong
Dopamine levels in the brain influence human consciousness. Inspired by the role of Catechol-O-methyltransferase (COMT) in inactivating dopamine in the brain, we investigated to what extent COMT could modulate individual's self-consciousness dispositions and self-consistency by genotyping the COMT Val158Met (rs4680) polymorphism and measuring self-consciousness and self-consistency and congruence in a college student population. The results indicated that COMT Val158Met polymorphism significantly modulated the private self-consciousness...
August 2016: Consciousness and Cognition
https://www.readbyqxmd.com/read/27462283/disorganization-comt-and-children-s-social-behavior-the-norwegian-hypothesis-of-legacy-of-disorganized-attachment
#15
Zhi Li, Beate W Hygen, Keith F Widaman, Turid S Berg-Nielsen, Lars Wichstrøm, Jay Belsky
Why is disorganized attachment associated with punitive-controlling behavior in some, but caregiving-controlling in others? Hygen et al. (2014) proposed that variation in the Catechol-O-methyl transferase(COMT) Val158Met genotype explains this variation, providing preliminary data to this effect. We offer a conceptual replication, analyzing data on 560 children (males: 275) drawn from the NICHD Study of Early Child Care and Youth Development. As predicted, competitive model-fitting indicated that disorganized infants carrying Met alleles engage in more positive behavior and less negative behavior than other children at age 5 and 11, with the reverse true of Val/Val homozygotes, seemingly consistent with caregiving-controlling and punitive-controlling styles, respectively, but only in the case of maternal and not teacher reports, thereby confirmating a relationship-specific hypothesis...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27458360/comt-val-158-met-polymorphism-is-associated-with-verbal-working-memory-in-neurofibromatosis-type-1
#16
Danielle de Souza Costa, Jonas J de Paula, Antonio M Alvim-Soares, Patrícia A Pereira, Leandro F Malloy-Diniz, Luiz O C Rodrigues, Marco A Romano-Silva, Débora M de Miranda
Neurofibromatosis type I (NF1) is a neurogenetic disease marked by multiple cognitive and learning problems. Genetic variants may account for phenotypic variance in NF1. Here, we investigated the association between the catechol-O-methyltransferase (COMT) Val(158)Met polymorphism and working memory and arithmetic performance in 50 NF1 individuals. A significant association of the COMT polymorphism was observed only with verbal working memory, as measured by the backward digit-span task with an advantageous performance for Met/Met carriers...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27458023/manic-symptom-severity-correlates-with-comt-activity-in-the-striatum-a-post-mortem-study
#17
Marco Bortolato, Consuelo Walss-Bass, Peter M Thompson, Jackob Moskovitz
OBJECTIVES: The enzyme catechol-O-methyltransferase (COMT), which catalyses the degradation of dopamine and norepinephrine, is posited to participate in the pathophysiology of bipolar disorder (BD) and schizophrenia. In support of this notion, rich evidence has documented that the severity of various BD and schizophrenia symptoms is moderated by rs4680, a single nucleotide polymorphism of the COMT gene featuring a valine (Val)-to-methionine (Met) substitution that results in lower catalytic activity...
July 26, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27445927/catechol-o-methyltransferase-val-158-met-polymorphism-interacts-with-sex-to-affect-face-recognition-ability
#18
Yvette N Lamb, Nicole S McKay, Shrimal S Singh, Karen E Waldie, Ian J Kirk
The catechol-O-methyltransferase (COMT) val158met polymorphism affects the breakdown of synaptic dopamine. Consequently, this polymorphism has been associated with a variety of neurophysiological and behavioral outcomes. Some of the effects have been found to be sex-specific and it appears estrogen may act to down-regulate the activity of the COMT enzyme. The dopaminergic system has been implicated in face recognition, a form of cognition for which a female advantage has typically been reported. This study aimed to investigate potential joint effects of sex and COMT genotype on face recognition...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27429661/neural-correlates-of-reward-processing-in-adults-with-22q11-deletion-syndrome
#19
Esther D A van Duin, Liesbet Goossens, Dennis Hernaus, Fabiana da Silva Alves, Nicole Schmitz, Koen Schruers, Therese van Amelsvoort
BACKGROUND: 22q11.2 deletion syndrome (22q11DS) is caused by a microdeletion on chromosome 22q11.2 and associated with an increased risk to develop psychosis. The gene coding for catechol-O-methyl-transferase (COMT) is located at the deleted region, resulting in disrupted dopaminergic neurotransmission in 22q11DS, which may contribute to the increased vulnerability for psychosis. A dysfunctional motivational reward system is considered one of the salient features in psychosis and thought to be related to abnormal dopaminergic neurotransmission...
2016: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/27426045/comt-and-prenatal-maternal-smoking-in-associations-with-conduct-problems-and-crime-the-pelotas-1993-birth-cohort-study
#20
Angélica Salatino-Oliveira, Joseph Murray, Christian Kieling, Júlia Pasqualini Genro, Guilherme Polanczyk, Luciana Anselmi, Fernando Wehrmeister, Fernando C de Barros, Ana Maria Baptista Menezes, Luis Augusto Rohde, Mara Helena Hutz
Conduct problems in childhood and adolescence are significant precursors of crime and violence in young adulthood. The purpose of the current study is to test the interaction between prenatal maternal smoking and COMT Val(158)Met in conduct problems and crime in the 1993 Pelotas Birth Cohort Study. Conduct problems were assessed through the parent version of the Strengths and Difficulties Questionnaire at ages 11 and 15 years. A translated version of a confidential self-report questionnaire was used to collect criminal data at 18 years of age...
2016: Scientific Reports
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