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https://www.readbyqxmd.com/read/29163477/genes-critical-for-developing-periodontitis-lessons-from-mouse-models
#1
REVIEW
Teun J de Vries, Stefano Andreotta, Bruno G Loos, Elena A Nicu
Since the etiology of periodontitis in humans is not fully understood, genetic mouse models may pinpoint indispensable genes for optimal immunological protection of the periodontium against tissue destruction. This review describes the current knowledge of genes that are involved for a proper maintenance of a healthy periodontium in mice. Null mutations of genes required for leukocyte cell-cell recognition and extravasation (e.g., Icam-1, P-selectin, Beta2-integrin/Cd18), for pathogen recognition and killing (e...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29152317/bone-marrow-derived-multipotent-mesenchymal-stromal-cells-from-horses-after-euthanasia
#2
Carmen Schröck, Carina Eydt, Florian Geburek, Lena Kaiser, Felicitas Päbst, Janina Burk, Christiane Pfarrer, Carsten Staszyk
Allogeneic equine multipotent mesenchymal stromal cells (eMSCs) have been proposed for use in regenerative therapies in veterinary medicine. A source of allogeneic eMSCs might be the bone marrow from euthanized horses. The purpose of this study was to compare in vitro characteristics of equine bone marrow derived eMSC (eBM-MSCs) from euthanized horses (eut-MSCs) and from narcotized horses (nar-MSCs). Eut-MSCs and nar-MSCs showed typical eMSC marker profiles (positive: CD44, CD90; negative: CD11a/CD18 and MHCII) and possessed tri-lineage differentiation characteristics...
November 2017: Veterinary Medicine and Science
https://www.readbyqxmd.com/read/29150602/tlr7-mediated-viral-recognition-results-in-focal-type-i-interferon-secretion-by-dendritic-cells
#3
Shin-Ichiroh Saitoh, Fumiko Abe, Atsuo Kanno, Natsuko Tanimura, Yoshiko Mori Saitoh, Ryutaro Fukui, Takuma Shibata, Katsuaki Sato, Takeshi Ichinohe, Mayumi Hayashi, Kazuishi Kubota, Hiroko Kozuka-Hata, Masaaki Oyama, Yorifumi Kikko, Toshiaki Katada, Kenji Kontani, Kensuke Miyake
Plasmacytoid dendritic cells (pDC) sense viral RNA through toll-like receptor 7 (TLR7), form self-adhesive pDC-pDC clusters, and produce type I interferons. This cell adhesion enhances type I interferon production, but little is known about the underlying mechanisms. Here we show that MyD88-dependent TLR7 signaling activates CD11a/CD18 integrin to induce microtubule elongation. TLR7(+) lysosomes then become linked with these microtubules through the GTPase Arl8b and its effector SKIP/Plekhm2, resulting in perinuclear to peripheral relocalization of TLR7...
November 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29141155/neutrophil-mediated-suppression-of-influenza-induced-pathology-requires-cd11b-cd18-mac-1
#4
Tamar Tak, Tomasz P Rygiel, Guruswamy Karnam, Okan W Bastian, Louis Boon, Marco Viveen, Frank E Coenjaerts, Linde Meyaard, Leo Koenderman, Janesh Pillay
Severe influenza virus infection can lead to life-threatening pathology through immune-mediated tissue damage. In various experimental models, this damage is dependent on T-cells. There is conflicting evidence regarding the role of neutrophils in influenza-mediated pathology. Neutrophils are often regarded as cells causing tissue damage, but in recent years it has become clear that a subset of human neutrophils is capable of suppressing T-cells, which is dependent on Mac-1 (CD11b/CD18). Therefore, we tested the hypothesis that immune suppression by neutrophils can reduce T-cell mediate pathology after influenza infection...
November 15, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29139565/leukocyte-adhesion-defect-i-rare-primary-immune-deficiency
#5
Nitesh Tewari, Vijay Prakash Mathur, Vikender Singh Yadav, Prabhat Chaudhari
Leukocyte adhesion defect I is a rare disorder (1:1,000,000) caused by diminished expression of CD-18 β2 integrins on leukocytes leading to abnormal adhesion, migration, and chemotaxis. Clinical manifestations include delayed separation of umbilical cord, omphalitis, recurrent severe infections, impaired wound healing, persistent oral ulcers, and severe periodontitis in primary and permanent dentition. A 5-year-old girl, second-born child to parents with consanguinity, presented with pain and mobility of lower teeth...
November 15, 2017: Special Care in Dentistry
https://www.readbyqxmd.com/read/29137380/inhibitors-of-telomerase-and-poly-adp-ribose-polymerases-synergize-to-limit-the-lifespan-of-pancreatic-cancer-cells
#6
Katrina M Burchett, Asserewou Etekpo, Surinder K Batra, Ying Yan, Michel M Ouellette
Imetelstat (GRN163L) is a potent and selective inhibitor of telomerase. We have previously reported that GRN163L could shorten telomeres and limit the lifespan of CD18/HPAF and CAPAN1 pancreatic cancer cells. Here, we examined the effects of GRN163L on two other pancreatic cancer cell lines: AsPC1 and L3.6pl. In both lines, chronic exposure to GRN163L led to an initial shortening of telomeres followed by a stabilization of extremely short telomeres. In AsPC1 cells, telomere attrition eventually led to the induction of crisis and the loss of the treated population...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29108477/hyperthermia-and-mild-traumatic-brain-injury-effects-on-inflammation-and-the-cerebral-vasculature
#7
Jessie Truettner, Helen M Bramlett, W Dalton Dietrich
Mild traumatic brain injury (mTBI) or concussion represents the majority of TBIs brain trauma in the United States. The pathophysiology of mTBI is complex and may include both focal and diffuse injury patterns. In addition to altered circuit dysfunction and diffuse traumatic axonal injury (DTAI), chronic neuroinflammation has also been implicated in the pathophysiology of mTBI. Recently, our laboratory has reported the detrimental effects of mild hyperthermic mTBI in terms of worsening histopathological and behavioral outcomes...
November 6, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29100055/extracellular-isg15-signals-cytokine-secretion-through-the-lfa-1-integrin-receptor
#8
Caleb D Swaim, Ariella F Scott, Larissa A Canadeo, Jon M Huibregtse
ISG15 is a ubiquitin-like protein that functions in innate immunity both as an intracellular protein modifier and as an extracellular signaling molecule that stimulates IFN-γ secretion. The extracellular function, important for resistance to mycobacterial disease, has remained biochemically uncharacterized. We have established an NK-92 cell-based assay for IFN-γ release, identified residues critical for ISG15 signaling, and identified the cell surface receptor as LFA-1 (CD11a/CD18; αLβ2 integrin). LFA-1 inhibition blocked IFN-γ secretion, splenocytes from CD11a(-/-) mice did not respond to ISG15, and ISG15 bound directly to the αI domain of CD11a in vitro...
November 2, 2017: Molecular Cell
https://www.readbyqxmd.com/read/29099772/role-of-lfa-1-and-icam-1-in-cancer
#9
REVIEW
Manuel Reina, Enric Espel
The lymphocyte function-associated antigen-1 (LFA-1) (also known as CD11a/CD18 and αLβ₂), is just one of many integrins in the human body, but its significance is derived from its exclusive presence in leukocytes. In this review, we summarize the studies relating LFA-1 and its major ligand ICAM-1 (or CD54) with cancer, through the function of lymphocytes and myeloid cells on tumor cells. We consider how LFA-1 mediates the interaction of leukocytes with tumors and the role of ICAM-1 in tumor dynamics, which can be independent of its interaction with LFA-1...
November 3, 2017: Cancers
https://www.readbyqxmd.com/read/29062662/hyperbaric-oxygen-inhibits-reperfusion-induced-neutrophil-polarization-and-adhesion-via-plasmin-mediated-vegf-release
#10
Ashish Francis, Shawna R Kleban, Linda L Stephenson, Patrick S Murphy, Peter R Letourneau, Xin-Hua Fang, Wei Z Wang, Richard C Baynosa
BACKGROUND: Ischemia-reperfusion (IR) injury is seen in many settings such as free flap salvage and limb replantation/revascularization. The consequences-partial/total flap loss, functional muscle loss, or amputation-can be devastating. Of the treatment options available for IR injury, hyperbaric oxygen (HBO) is the most beneficial. HBO inhibits neutrophil-endothelial adhesion through interference of CD18 neutrophil polarization in IR, a process mediated by nitric oxide. The purposes of this study were to examine the involvement of vascular endothelial growth factor (VEGF) in the beneficial HBO effect on CD18 polarization and neutrophil adhesion and investigate the effect of plasmin on VEGF expression in skeletal muscle following IR injury...
September 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29042015/identification-of-monoclonal-antibodies-cross-reactive-with-bottlenose-dolphin-orthologues-of-the-major-histocompatibility-complex-and-leukocyte-differentiation-molecules
#11
Mahmoud M Elnaggar, Gaber S Abdellrazeq, Stephanie K Venn-Watson, Eric D Jensen, Victoria Hulubei, Lindsay M Fry, Randy E Sacco, William C Davis
The slow progress in understanding immunotoxic effects of environmental contaminants and their influence on disease susceptibility in whales is largely due to the limited information available on the immune systems and immune function of species included in the Cetancodontamorpha clade. Studies in species in the other major clades included in the Artiodactylamorpha, Ruminantiamorpha, Suinamorpha, and Camelidamorpha have revealed the immune systems are similar, but not identical. The present study was undertaken to expand the available monoclonal antibody reagents needed to gain insight into the composition, function, and evolution of the immune system in Cetancodontamorpha, using the dolphin (Tursiops truncatus) as a model cetacean species...
October 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29030341/macrophage-overexpression-of-matrix-metalloproteinase-9-in-aged-mice-improves-diastolic-physiology-and-cardiac-wound-healing-following-myocardial-infarction
#12
Cesar A Meschiari, Mira Jung, Rugmani Padmanabhan Iyer, Andriy Yabluchanskiy, Hiroe Toba, Michael R Garrett, Merry L Lindsey
Matrix metalloproteinase (MMP)-9 increases in the myocardium with advanced age and after MI. Because young transgenic (TG) mice overexpressing human MMP-9 only in macrophages mice show better outcomes post-MI, while aged TG mice show a worse aging phenotype, we wanted to evaluate the combination effect to see if the detrimental effect of aging counteracted the benefits of macrophage MMP-9 overexpression. We used 17-28 month old male and female C57BL/6J wild type (WT) mice and TG mice (n = 10-21/group) to evaluate the effects of aging superimposed on MI...
October 13, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28983472/aspartic-proteases-and-major-cell-wall-components-in-candida-albicans-trigger-the-release-of-neutrophil-extracellular-traps
#13
Marcin Zawrotniak, Oliwia Bochenska, Justyna Karkowska-Kuleta, Karolina Seweryn-Ozog, Wataru Aoki, Mitsuyoshi Ueda, Andrzej Kozik, Maria Rapala-Kozik
Neutrophils use different mechanisms to cope with pathogens that invade the host organism. The most intriguing of these responses is a release of neutrophil extracellular traps (NETs) composed of decondensed chromatin and granular proteins with antimicrobial activity. An important potential target of NETs is Candida albicans-an opportunistic fungal pathogen that employs morphological and phenotype switches and biofilm formation during contact with neutrophils, accompanied by changes in epitope exposition that mask the pathogen from host recognition...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28968518/beneficial-role-of-the-phytoestrogen-genistein-on-vascular-calcification
#14
Sabrina B Cepeda, Marisa J Sandoval, María B Rauschemberger, Virginia L Massheimer
Although soy phytoestrogen are proposed to prevent or improve postmenopausal vascular and bone diseases, the currently available data are controversial and unclear. In this study we evaluated the molecular and biochemical action of genistein on the cellular events involved in vascular calcification. Rat monocytes, aortic vascular cell and osteoblasts cultures in vitro exposed to Gen were employed. Gen down regulated the expression of cell adhesion molecules involved in stable leukocyte attachment. Using flow cytometry we found that the PE significantly diminished monocyte integrins CD11b, CD11c and CD18 expression either under basal and pro-inflammatory environment...
August 24, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28954823/a-novel-intracellular-pool-of-lfa-1-is-critical-for-asymmetric-cd8-t-cell-activation-and-differentiation
#15
Tara Capece, Brandon L Walling, Kihong Lim, Kyun-Do Kim, Seyeon Bae, Hung-Li Chung, David J Topham, Minsoo Kim
The integrin lymphocyte function-associated antigen 1 (LFA-1; CD11a/CD18) is a key T cell adhesion receptor that mediates stable interactions with antigen-presenting cell (APC), as well as chemokine-mediated migration. Using our newly generated CD11a-mYFP knock-in mice, we discovered that naive CD8(+) T cells reserve a significant intracellular pool of LFA-1 in the uropod during migration. Intracellular LFA-1 quickly translocated to the cell surface with antigenic stimulus. Importantly, the redistribution of intracellular LFA-1 at the contact with APC was maintained during cell division and led to an unequal inheritance of LFA-1 in divided T cells...
November 6, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28946636/structure-function-relationships-underlying-the-capacity-of-bordetella-adenylate-cyclase-toxin-to-disarm-host-phagocytes
#16
REVIEW
Jakub Novak, Ondrej Cerny, Adriana Osickova, Irena Linhartova, Jiri Masin, Ladislav Bumba, Peter Sebo, Radim Osicka
Bordetellae, pathogenic to mammals, produce an immunomodulatory adenylate cyclase toxin-hemolysin (CyaA, ACT or AC-Hly) that enables them to overcome the innate immune defense of the host. CyaA subverts host phagocytic cells by an orchestrated action of its functional domains, where an extremely catalytically active adenylyl cyclase enzyme is delivered into phagocyte cytosol by a pore-forming repeat-in-toxin (RTX) cytolysin moiety. By targeting sentinel cells expressing the complement receptor 3, known as the CD11b/CD18 (αMβ₂) integrin, CyaA compromises the bactericidal functions of host phagocytes and supports infection of host airways by Bordetellae...
September 24, 2017: Toxins
https://www.readbyqxmd.com/read/28939773/pleiotrophin-a-multifunctional-cytokine-and-growth-factor-induces-leukocyte-responses-through-the-integrin-mac-1
#17
Di Shen, Nataly P Podolnikova, Valentin P Yakubenko, Christopher L Ardell, Arnat Balabiyev, Tatiana P Ugarova, Xu Wang
Pleiotrophin (PTN) is a multifunctional, cationic, glycosaminoglycan-binding cytokine and growth factor involved in numerous physiological and pathological processes, including tissue repair and inflammation-related diseases. PTN has been shown to promote leukocyte responses by inducing their migration and expression of inflammatory cytokines. However, the mechanisms through which PTN mediates these responses remain unclear. Here, we identified the integrin Mac-1 (αMβ2, CD11b/CD18) as the receptor mediating macrophage adhesion and migration to PTN...
September 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28934133/understanding-the-mechanism-of-translocation-of-adenylate-cyclase-toxin-across-biological-membranes
#18
REVIEW
Helena Ostolaza, César Martín, David González-Bullón, Kepa B Uribe, Asier Etxaniz
Adenylate cyclase toxin (ACT) is one of the principal virulence factors secreted by the whooping cough causative bacterium Bordetella pertussis, and it has a critical role in colonization of the respiratory tract and establishment of the disease. ACT targets phagocytes via binding to the CD11b/CD18 integrin and delivers its N-terminal adenylate cyclase (AC) domain directly to the cell cytosol, where it catalyzes unregulated conversion of cytosolic ATP into cAMP upon activation by binding to cellular calmodulin...
September 21, 2017: Toxins
https://www.readbyqxmd.com/read/28904019/cathepsin-b-mediated-cd18-shedding-regulates-leukocyte-recruitment-from-angiogenic-vessels
#19
Shintaro Nakao, Souska Zandi, Dawei Sun, Ali Hafezi-Moghadam
Cathepsin B (CtsB) contributes to atherosclerosis and cancer progression by processing the extracellular matrix and promoting angiogenesis. Although CtsB was reported to promote and reduce angiogenesis, there is no mechanistic explanation that reconciles this apparent discrepancy. CtsB cleaves CD18 from the surface of immune cells, but its contribution to angiogenesis has not been studied. We developed an in vivo technique for visualization of immune cell transmigration from corneal vessels toward implanted cytokines...
September 13, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28873429/cd18-deficiency-improves-liver-injury-in-the-mcd-model-of-steatohepatitis
#20
Andrew A Pierce, Caroline C Duwaerts, Kevin Siao, Aras N Mattis, Amanda Goodsell, Jody L Baron, Jacquelyn J Maher
Neutrophils and macrophages are important constituents of the hepatic inflammatory infiltrate in non-alcoholic steatohepatitis. These innate immune cells express CD18, an adhesion molecule that facilitates leukocyte activation. In the context of fatty liver, activation of infiltrated leukocytes is believed to enhance hepatocellular injury. The objective of this study was to determine the degree to which activated innate immune cells promote steatohepatitis by comparing hepatic outcomes in wild-type and CD18-mutant mice fed a methionine-choline-deficient (MCD) diet...
2017: PloS One
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