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Osteonecrosis of knee

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https://www.readbyqxmd.com/read/29882123/effects-of-press-fit-biphasic-collagen-and-ha-%C3%AE-tcp-scaffold-with-cell-based-therapy-on-cartilage-and-subchondral-bone-repair-knee-defect-in-rabbits
#1
Jacques Hernigou, Pascale Vertongen, Esfandiar Chahidi, Theofylaktos Kyriakidis, Jean-Paul Dehoux, Magalie Crutzen, Sébastien Boutry, Lionel Larbanoix, Sarah Houben, Nathalie Gaspard, Dimitrios Koulalis, Joanne Rasschaert
INTRODUCTION: Human spontaneous osteonecrosis of the knee (SPONK) is still challenging as the current treatments do not allow the production of hyaline cartilage tissue. The aim of the present study was to explore the therapeutic potential of cartilage regeneration using a new biphasic scaffold (type I collagen/hydroxyapatite) previously loaded or not with concentrated bone marrow cells. MATERIAL AND METHODS: Female rabbits were operated of one knee to create articular lesions of the trochlea (three holes of 4 × 4mm)...
June 7, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29788942/use-of-autologous-bone-marrow-stem-cell-implantation-for-osteonecrosis-of-the-knee-in-sickle-cell-disease-a-preliminary-report
#2
Gildasio Daltro, Bruno Adelmo Franco, Thiago Batista Faleiro, Davi Araujo Veiga Rosário, Paula Braga Daltro, Roberto Meyer, Vitor Fortuna
BACKGROUND: The purpose of our study was to evaluate safety, feasibility and clinical results of bone marrow mononuclear cell (BMC) implantation for early-stage osteonecrosis of the knee (OK) secondary to sickle cell disease. METHODS: Thirty-three SCD patients (45 knees) with OK treated with BMC implantation in the osteonecrotic lesion were clinically and functionally evaluated through the American Knee Society Clinical Score (KSS), Knee Functional Score (KFS) and Numeric Rating Scale (NRS) pain score...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29776813/unicompartmental-knee-arthroplasty-for-spontaneous-osteonecrosis-of-the-medial-tibial-plateau
#3
Tomoyuki Kamenaga, Takafumi Hiranaka, Yuichi Hida, Takaaki Fujishiro, Koji Okamoto
BACKGROUND: There have been very few reports on isolated medial tibial plateau osteonecrosis, and the condition has not been clearly described. Unicompartmental knee arthroplasty (UKA) may be an appropriate treatment method for this condition. The aims of this study were to report our experience of using mobile-bearing knee implants for osteonecrosis of the medial tibial plateau and to discuss the etiology and treatment of this type of osteonecrosis. METHODS: This study included six consecutive patients with isolated medial tibial plateau osteonecrosis treated with an Oxford mobile-bearing knee implant...
May 16, 2018: Knee
https://www.readbyqxmd.com/read/29771856/vitamin-e-phosphate-coating-stimulates-bone-deposition-in-implant-related-infections-in-a-rat-model
#4
Arianna B Lovati, Marta Bottagisio, Susanna Maraldi, Martina B Violatto, Monica Bortolin, Elena De Vecchi, Paolo Bigini, Lorenzo Drago, Carlo L Romanò
BACKGROUND: Implant-related infections are associated with impaired bone healing and osseointegration. In vitro antiadhesive and antibacterial properties and in vivo antiinflammatory effects protecting against bone loss of various formulations of vitamin E have been demonstrated in animal models. However, to the best of our knowledge, no in vivo studies have demonstrated the synergistic activity of vitamin E in preventing bacterial adhesion to orthopaedic implants, thus supporting the bone-implant integration...
June 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29739709/osteonecrosis-of-bipartite-patella-following-total-knee-arthroplasty-without-lateral-release
#5
Jung Ho Noh, Young Hak Roh
We present a case of osteonecrosis of bipartite patella occurring after total knee arthroplasty using medial parapatellar approach without lateral retinacular release in osteoarthritic knee of a 66 year-old-male. The surgery was performed using traditional technique with medial parapatellar approach and patella was resurfaced. Patella was everted during surgery. There was no event during follow-up period after surgery. Range of motion of the knee was 135° without flexion contracture. Eight months after the surgery, patella was fragmented and resorbed on the radiographs which was consistent with osteonecrosis...
May 5, 2018: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29718744/osteonecrosis-in-children-with-acute-lymphoblastic-leukemia-at-initial-diagnosis-and-prior-to-any-chemotherapy
#6
Kathinka Krull, Marina Kunstreich, Annika Bronsema, Kirsten Bleckmann, Carl-Friedrich Classen, Bernhard Erdlenbruch, Norbert Jorch, Reinhard Kolb, Alfred Leipold, Olga Moser, Aram Prokop, Wolfram Scheurlen, Daniel Steinbach, Janina Klasen-Sansone, Dirk Klee, Gabriele Escherich, Anja Moericke, Martin Schrappe, Arndt Borkhardt, Michaela Kuhlen
Osteonecrosis (ON) is a common and debilitating side effect of anti-leukemic treatment in children with acute lymphoblastic leukemia (ALL). However, the impact of leukemia itself on ON development remains elusive. We analyzed 76 children enrolled in the ongoing OPAL trial, who had magnetic resonance imaging (MRI) studies at diagnosis. MRI screening revealed 14 osteonecrotic lesions (5 × hips, 9 × knees) of any grade (I-III) in 7 (9.2%) patients. Six months on, the number of ON per patient increased (1 patient), remained constant (2), and decreased (2)...
May 2, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29665764/unicompartmental-knee-arthroplasty-for-spontaneous-osteonecrosis-of-the-knee-a-meta-analysis
#7
Julio J Jauregui, Christopher L Blum, Neil Sardesai, Craig Bennett, R Frank Henn, Farshad Adib
BACKGROUND: Spontaneous osteonecrosis of the knee (SONK) is a poorly understood but debilitating disease entity. Total knee arthroplasty (TKA) is the standard of care for those patients who fail conservative management, but considering SONK's predilection for affecting a single knee compartment, unicompartmental knee arthroplasty (UKA) appears to be a more tailored option. Unfortunately, conflicting data exist on the utility of UKA in SONK. Thus, the purpose of this study was to evaluate functional outcomes and revision rates of UKA in the setting of SONK...
May 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29663012/medial-joint-line-elevation-of-the-tibia-measured-during-surgery-has-a-significant-correlation-with-the-limb-alignment-changes-following-medial-unicompartmental-knee-arthroplasty
#8
Yuichi Kuroda, Koji Takayama, Kazunari Ishida, Shinya Hayashi, Shingo Hashimoto, Masanori Tsubosaka, Takehiko Matsushita, Takahiro Niikura, Kotaro Nishida, Ryosuke Kuroda, Tomoyuki Matsumoto
PURPOSE: This study aimed to determine the correlation between the change in joint line height calculated from the resected bone and insert thickness during surgery and the change in limb alignment following unicompartmental knee arthroplasty (UKA). It was hypothesized that joint line elevation is correlated with the change in limb alignment. METHODS: A total of 74 consecutive patients diagnosed with either isolated medial compartmental osteoarthritis (38 patients) or spontaneous osteonecrosis of the knee (36 patients) were included...
April 16, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29629588/reliable-outcomes-and-survivorship-of-unicompartmental-knee-arthroplasty-for-isolated-compartment-osteonecrosis
#9
B P Chalmers, K G Mehrotra, R J Sierra, M W Pagnano, M J Taunton, M P Abdel
Aims Primary (or spontaneous) and secondary osteonecrosis of the knee can lead to severe joint degeneration, for which either total or unicompartmental arthroplasty may be considered. However, there are limited studies analyzing outcomes of unicompartmental knee arthroplasties (UKAs) for osteonecrosis involving an isolated compartment of the knee. The aims of this study were to analyze outcomes of UKAs for osteonecrosis with specific focus on 1) survivorship free of any revision or reoperation, 2) risk factors for failure, 3) clinical outcomes, and 4) complications...
April 1, 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29611159/perioperative-outcomes-and-short-term-complications-following-total-knee-arthroplasty-in-chronically-immunosuppressed-patients
#10
Gannon L Curtis, Morad Chughtai, Anton Khlopas, Jared M Newman, Assem A Sultan, Nipun Sodhi, Wael K Barsoum, Carlos A Higuera, Michael A Mont
BACKGROUND: Although there are studies regarding immunosuppressed patients undergoing total knee arthroplasty (TKA) for inflammatory arthritis or osteonecrosis, there is a paucity of studies evaluating immunosuppressed patients undergoing TKA for diagnoses other than these. MATERIALS AND METHODS: We identified all patients undergoing primary TKA for osteoarthritis from 2008-2014 in the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) database...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29589086/subchondral-stem-cell-therapy-versus-contralateral-total-knee-arthroplasty-for-osteoarthritis-following-secondary-osteonecrosis-of-the-knee
#11
Philippe Hernigou, Jean Charles Auregan, Arnaud Dubory, Charles Henri Flouzat-Lachaniette, Nathalie Chevallier, Helene Rouard
PURPOSE: Total knee arthroplasty (TKA) implanted in patients with secondary osteonecrosis (ON) related to corticosteroids have relatively poor outcome (20% revision rate) at a mean follow-up of only eight years. With the hypothesis that subchondral bone marrow injection might improve knees in these patients, we evaluated 30 patients who had bilateral knee osteoarthritis with severe joint space narrowing and received TKA in one knee and subchondral bone marrow concentrate injection in the contralateral knee...
March 27, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29582115/osteonecrosis-in-sickle-cell-disease-patients-from-bahia-brazil-a-cross-sectional-study
#12
Gildasio Daltro, Bruno Adelmo Franco, Thiago Batista Faleiro, Davi Araujo Veiga Rosário, Paula Braga Daltro, Vitor Fortuna
PURPOSE: The aim of this study was to describe the clinical features of osteonecrosis (ON) in sickle cell disease (SCD) patients in Bahia, a Northeast state with the highest prevalence of the disease in Brazil. METHODS: Between 2006 and 2017, 283 cases of osteonecrosis in SCD patients were enrolled to analyse the age at diagnosis, genotype, gender, pain, distribution of the lesions and disease staging. MRI and radiograph were obtained at the participation. RESULTS: Of the 283 SCD cases, 120 (42...
March 26, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29552689/characteristics-management-and-outcomes-of-spontaneous-osteonecrosis-of-the-knee-in-indian-population
#13
Nishit Bhatnagar, Siddharth Sharma, Virender Kumar Gautam, Ajeet Kumar, Anurag Tiwari
PURPOSE: Spontaneous osteonecrosis of the knee affects the medial femoral condyle in patients above 55 years of age. Many reports and studies are available from western countries. But there is a gross paucity of literature on spontaneous osteonecrosis of the knee (SPONK) in the Indian subcontinent, either it is under-reported or detected at a later stage. The aim of our study was to detect SPONK in Indian population and describe its characteristics, treatment, and outcome. MATERIAL AND METHOD: A prospective study was conducted over a period of three years...
March 18, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29523954/do-femoral-head-collapse-and-the-contralateral-condition-affect-patient-reported-quality-of-life-and-referral-pain-in-patients-with-osteonecrosis-of-the-femoral-head
#14
Yusuke Osawa, Taisuke Seki, Yasuhiko Takegami, Takehiro Kasai, Yoshitoshi Higuchi, Naoki Ishiguro
PURPOSES: The objectives of this study were to investigate patient-reported outcomes and referral pain at the first visit in patients with osteonecrosis of the femoral head (ONFH) and to clarify the influence of collapse of the femoral head and the contralateral condition. METHODS: The study included 105 patients (130 hips) with ONFH at the first visit, who were divided into two groups based on the presence of bilateral walking hip pain (bilateral group 25 patients, 50 hips) and unilateral hip pain (unilateral group 80 patients, 80 hips)...
March 9, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29469958/long-term-experience-with-intranasal-bevacizumab-therapy
#15
Johan Steineger, Terje Osnes, Ketil Heimdal, Sinan Dheyauldeen
OBJECTIVES/HYPOTHESIS: Long-term follow-up of intranasal bevacizumab therapy in hereditary hemorrhagic telangiectasia (HHT). STUDY DESIGN: Prospective, noncomparative study. METHODS: Patients treated for HHT-associated epistaxis by intranasal submucosal bevacizumab injections between June 2011 and August 2013 were included and followed prospectively. The effectiveness of the treatment was evaluated by the epistaxis severity score (ESS); the epistaxis intensity, frequency, and the need of blood transfusion (IFT) score; and hemoglobin levels...
February 22, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29462407/transitional-changes-in-the-incidence-of-osteonecrosis-in-systemic-lupus-erythematosus-patients-focus-on-immunosuppressant-agents-and-glucocorticoids
#16
Kento Nawata, Junichi Nakamura, Kei Ikeda, Shunsuke Furuta, Hiroshi Nakajima, Seiji Ohtori, Shigeo Hagiwara, Yasushi Wako, Michiaki Miura, Yuya Kawarai, Masahiko Sugano, Kensuke Yoshino, Sumihisa Orita, Kazuhide Inage, Tsutomu Akazawa
Objective: The purpose of this study was to investigate transitional changes in the incidence of glucocorticoid-associated osteonecrosis in SLE patients, with a focus on immunosuppressive agent and glucocorticoid consumption. Methods: We retrospectively registered 185 SLE patients with 740 joints, who were newly diagnosed and hospitalized for initial high-dose glucocorticoid therapy from 1986 to 2015. Immunosuppressive agent, glucocorticoid dose, age, sex, organ lesion at hospitalization, complement (C3, C4, CH50) and anti-DNA antibody before initial glucocorticoid therapy, the frequency of use of anticoagulant and antilipidemic drugs, and incidence of osteonecrosis were documented...
May 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/29316597/radiographic-classification-systems-for-osteonecrosis-of-the-knee-a-review-of-literature
#17
Assem A Sultan, William A Cantrell, Morad Chughtai, Prem N Ramkumar, Anton Khlopas, Jared M Newman, Nipun Sodhi, Suela Lamaj, Timothy C Wagner, Linsen T Samuel, Michael A Mont
Knee osteonecrosis is a rare, yet debilitating disease that can lead to knee joint destruction and can be associated with significant pain and disability. Various imaging modalities have different roles in the diagnosis, staging, management, and determination of the prognosis in knee osteonecrosis. Plain radiographic images can show gross joint destruction and secondary arthritic changes. In addition, magnetic resonance imaging (MRI) has become the gold-standard imaging modality to diagnose osteonecrosis. Multiple classification systems have been developed for knee osteonecrosis based on these imaging modalities...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29299471/outcomes-of-a-newer-generation-cementless-total-knee-arthroplasty-design-in-patients-less-than-50-years-of-age
#18
Michael A Mont, Chukwuweike Gwam, Jared M Newman, Morad Chughtai, Anton Khlopas, Prem N Ramkumar, Steven F Harwin
Background: Younger patients undergoing cemented total knee arthroplasty (TKA) may be at risk for lower implant survivorship and higher revision rates due to the historical increased prevalence of aseptic loosening and instability in this cohort. The recent advances of cementless TKAs may mitigate some of these complications. However, there is a paucity of studies reporting on patients who are under 50 years who have undergone a cementless TKA. Therefore, this study evaluated: (I) implant survivorship; (II) functional outcomes and complications; and (III) radiographic outcomes in patients who were less than 50 years of age and underwent cementless TKA...
December 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29202561/meniscal-extrusion-as-booster-of-osteoarthritis
#19
R Papalia, G Papalia, F Russo, L A Diaz, F Bressi, S Sterzi, V Denaro
Meniscal extrusion (ME) has shown to play a critical but still unclear role in osteoarthritis (OA) development. ME has been described as an important risk factor in the progression of knee OA, as it is involved in the thinning of articular cartilage, joint space narrowing, spontaneous osteonecrosis of the knee and subchondral bone marrow lesions. Meniscal damage of any degree of severity could cause ME in both compartments, but it is commonly associated with severe meniscal tears or root tears mainly in the medial meniscus...
December 27, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29128233/cementless-total-knee-arthroplasty-in-knee-osteonecrosis-demonstrated-excellent-survivorship-and-outcomes-at-three-year-minimum-follow-up
#20
Assem A Sultan, Anton Khlopas, Nipun Sodhi, Mark L Denzine, Prem N Ramkumar, Steven F Harwin, Michael A Mont
BACKGROUND: Lack of consensus exists on the use of cementless total knee arthroplasty (TKA) in patients with knee osteonecrosis. Therefore, this study was conducted to evaluate (1) implant survivorship; (2) clinical outcomes and complications; and (3) radiographic outcomes of primary cementless TKA in knee osteonecrosis. METHODS: This study included 46 patients (49 knees) who had knee osteonecrosis and underwent primary cementless TKA and had a mean follow-up of 44 months (range 36-96)...
March 2018: Journal of Arthroplasty
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